CN106633923A - Degradable medical composite novel material and preparation method thereof - Google Patents
Degradable medical composite novel material and preparation method thereof Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L97/00—Compositions of lignin-containing materials
- C08L97/02—Lignocellulosic material, e.g. wood, straw or bagasse
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/014—Additives containing two or more different additives of the same subgroup in C08K
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2201/00—Properties
- C08L2201/06—Biodegradable
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/14—Polymer mixtures characterised by other features containing polymeric additives characterised by shape
- C08L2205/16—Fibres; Fibrils
Abstract
The invention discloses a degradable medical composite novel material and a preparation method thereof. The degradable medical composite novel material is prepared from the following raw materials in parts by weight: 20 to 30 parts of polyvinyl acetate, 20 to 30 parts of polyhydroxyalkanoate, 10 to 20 parts of starch, 65 to 90 parts of plant fiber, 1 to 2 parts of crofton weed, 1 to 2 parts of a lubricating agent, 1 to 2 parts of a plasticizer, 1 to 2 parts of an anti-freezing agent, 1 to 3 parts of a cross-linking agent and 1 to 2 parts of a waterproof agent. The degradable medical composite novel material prepared according to the preparation method is high in tensile strength, bending strength and elongation at break, high in natural degradation rate and waterproof, and is applicable to production of medical bag products. The composite novel material disclosed by the invention is simple in preparation method, and is applicable to large-scale industrial production.
Description
Technical field
The present invention relates to a kind of medical new material, more particularly to a kind of degradable medical composite material and its preparation side
Method.
Background technology
Bio-medical material is for its disease damage tissue, organ or increasing is diagnosed, treated, repaired or replaced to organism
Enter the material of its function.It is the basis for studying artificial organs and medicine equipment, it has also become the important branch of contemporary material subject,
Flourishing and important breakthrough especially with biotechnology, bio-medical material has become various countries scientist and has competitively been ground
The focus studied carefully and develop.Bio-medical composition is also called Biocomposite material, and it is by two or more different material
The bio-medical material that material is composited, and compared with the performance of its all monomer, the performance of composite has larger journey
The material of the raising of degree.The purpose for preparing such material is exactly further to improve or improve the performance of a certain biomaterial.Should
Class material is mainly used in the manufacture repaired or replace tissue, organ or promote its function and artificial organs.It is removed should have
Have outside expected physicochemical properties, it is necessary to meet the requirement of biocompatibility.Here component material itself is not required nothing more than
It must is fulfilled for biocompatibility requirement, and the compound property for not allowing to occur damaging material biology performance afterwards.By base material
Decomposing biological composite can be divided into polymer-based, Metal Substrate and the class of inorganic non-metallic three.They both can be used as biological composite wood
The base material of material, but also as reinforcement or filler, being collocated with each other between them or collectively form a large amount of distinct lifes
Thing medical composite material.Using biotechnology, the growth factor of some biological tissues, cell and inducing tissue regeneration is introduced into
Bio-medical material, substantially improves its biology performance, and can make it have drug therapy function, it has also become bio-medical material
One highly important developing direction of material.The tissue reaction's type caused after being implanted according to material and level, it again may be used
Be divided into biologically inert, biologically active, it is biodegradable and absorb etc. several types.Medical material is typically adopted at present can not
Degradable material is made, and as fossil fuel resource and plastics post-process the increase of pressure, researches and develops biodegradable high score
Sub- material becomes the focus of macromolecule educational circles research.
Patent 201510640988.2 discloses a kind of PLA-bacteria cellulose medical composite material and its preparation side
Method.Including following component：PLA 36-46 parts, bacteria cellulose 34-50 parts, Graphene 6-12 parts, 2- methacryloxies
Ethylphosphocholine 0.1-10 parts, OPC 2-5 parts, polyethylene glycol 2-5 parts, calcium chloride 0.2-0.8 parts, lubricant 1-4 parts
With auxiliary agent 1-3 parts.Although the medical material can degrade, degradation rate is low, and the material tension of preparation, compressive property is not high,
It is non-watertight.
The content of the invention
It is an object of the invention to provide degradable medical composite material and preparation method thereof.
A kind of degradable medical composite material, is made up of the raw material of following parts by weight：Polyvinyl acetate 20-30 parts,
Polyhydroxyalkanoate 20-30 parts, starch 10-20 parts, string 65-90 parts, Eupatorium adenophorum 1-2 parts, lubricant 1-2 parts,
Plasticizer 1-2 parts, antifreeze 1-2 parts, crosslinking agent 1-3 parts, waterproofing agent 1-2 parts.
The string is fibre and soya, and corn stalk powder, wheat stalk powder, bark fiber, sisal fiber, ramie is fine
Dimension, one or more in bamboo pulp fiber.
The lubricant be Macrogol 6000, PEG 8000, terpene polymer, the one kind or one kind in paste of soap with
On.
The plasticizer be diethyl phthalate, the bromo- fluorenes -9- ketone of 2-, benzoic acid, tetramethylthiuram monosulfide,
2- propyl enanthols, one or more in isobutyl isobutyrate.
The antifreeze be p-aminobenzoic acid, mannitol, trehalose, sodium citrate, triethylene glycol dimethacrylate
Ester, one or more in 3 Methylbutanoic acid butyl ester.
The crosslinking agent be benzotriazole, saualane, chromium acetate, lauryl dimethyl tertiary amine, a hydroxymethylphenol, phosphorus
Sour hydrogen dipotassium, 5- hydroxyls -2 pentanone, 2- (2- Butoxyethoxies) ethanol, the one kind or one kind in asymmetric diisocyanate
More than.
The waterproofing agent be fatty acid distribution of coconut oil, stearic acid, glyceryl stearate, acrylate, 22 carbon -13- olefin(e) acids,
Octadecylisocyanate, one or more in pentaerythritol stearate.
The preparation method of above-mentioned degradable medical composite material, is carried out in accordance with the following steps：
(1) according to parts by weight, polyvinyl acetate 20-30 parts, polyhydroxyalkanoate 20-30 parts, starch 10-20 are taken
Part, string 65-90 parts, ultramicro grinding is mixed, and in being put into 800-1000 part ethanol, dispersion liquid is made in quick stirring；
(2) cauline leaf of Eupatorium adenophorum is taken, is dried, clayed into power, cross 150-200 mesh sieves, obtain Eupatorium adenophorum dry powder, taken
Eupatorium adenophorum dry powder 1-2 part, in being added to the dispersion liquid of step (1) preparation；
(3) the dispersion liquid room temperature volatilization for preparing step (2) is removed after ethanol, and lubricant 1-2 parts, plasticizer 1-2 parts,
Antifreeze 1-2 parts, crosslinking agent 1-3 parts, waterproofing agent 1-2 parts are well mixed, and are added in parallel dual-screw compounding extrusion machine and extrude
Granulation, the temperature setting of extruder is 120-150 DEG C, and screw speed is 460-500r/min, and charging rate is about 10-15g/
Min, water cooling is obtained degradable medical composite material, and after the granulation of Jing pelleters, be finally placed in 50-60 DEG C of baking oven and dry
Do to constant mass.
Compared with prior art, the present invention has the advantages that：The compound green wood of degradable medical prepared by the present invention
Material, tensile strength, bending strength, elongation at break is high, and natural degradation speed is fast, waterproof, it is adaptable to the life of medical bag product
Produce, the composite material preparation method of the present invention is simple, is adapted to large-scale industrial production.
Specific embodiment
The specific embodiment of the present invention is described in detail below, it is to be understood that protection scope of the present invention is not
Limited by specific embodiment.
Embodiment 1
A kind of degradable medical composite material, is made up of the raw material of following parts by weight：25 parts of polyvinyl acetate, poly- hydroxyl
25 parts of base fatty acid ester, 15 parts of starch, 80 parts of fibre and soya, 1.5 parts of Eupatorium adenophorum, 1.5 parts of Macrogol 6000, adjacent benzene two
1.5 parts of formic acid diethylester, 1.5 parts of p-aminobenzoic acid, 2 parts of saualane, 1.5 parts of fatty acid distribution of coconut oil.
The preparation method of above-mentioned degradable medical composite material, is carried out in accordance with the following steps：
(1) according to parts by weight, 25 parts of polyvinyl acetate, 25 parts of polyhydroxyalkanoate, 15 parts of starch, fibre and soya 80
Part, ultramicro grinding is mixed, and in being put into 900 parts of ethanol, dispersion liquid is made in quick stirring；
(2) cauline leaf of Eupatorium adenophorum is taken, is dried, clayed into power, cross 180 mesh sieves, obtain Eupatorium adenophorum dry powder, take purple stem
1.5 parts of Herba Lycopi's dry powder, in being added to the dispersion liquid of step (1) preparation；
(3) the dispersion liquid room temperature volatilization for preparing step (2) is removed after ethanol, with 1.5 parts of Macrogol 6000, adjacent benzene
1.5 parts of dicarboxylate, 1.5 parts of p-aminobenzoic acid, 2 parts of saualane, 1.5 parts of fatty acid distribution of coconut oil is well mixed, and is added to
Extruding pelletization in parallel dual-screw compounding extrusion machine, the temperature setting of extruder is 130 DEG C, and screw speed is 480r/min, plus
Material speed is about 12g/min, water cooling, is obtained degradable medical composite material, and after the granulation of Jing pelleters, be finally placed in 55
DEG C drying in oven is to constant mass.
Degradable medical composite material manufactured in the present embodiment, 60 days in the soil that relative humidity is 80% in automatically
Degraded, tensile strength 108Mpa, elongation at break 32%, bending strength 228Mpa.
Embodiment 2
A kind of degradable medical composite material, is made up of the raw material of following parts by weight：20 parts of polyvinyl acetate, poly- hydroxyl
20 parts of base fatty acid ester, 10 parts of starch, 30 parts of corn stalk powder, 35 parts of wheat stalk powder, 1 part of Eupatorium adenophorum, polyethylene glycol
80001 parts, 1 part of the bromo- fluorenes -9- ketone of 2-, 1 part of trehalose, 1 part of lauryl dimethyl tertiary amine, 1 part of acrylate.
The preparation method of above-mentioned degradable medical composite material, is carried out in accordance with the following steps：
(1) according to parts by weight, 20 parts of polyvinyl acetate, 20 parts of polyhydroxyalkanoate, 10 parts of starch, maize straw are taken
30 parts of powder, 35 parts of wheat stalk powder, ultramicro grinding is mixed, and in being put into 800 parts of ethanol, dispersion liquid is made in quick stirring；
(2) cauline leaf of Eupatorium adenophorum is taken, is dried, clayed into power, cross 150 mesh sieves, obtain Eupatorium adenophorum dry powder, take purple stem
1 part of Herba Lycopi's dry powder, in being added to the dispersion liquid of step (1) preparation；
(3) the dispersion liquid room temperature volatilization for preparing step (2) is removed after ethanol, and 1 part of PEG 8000, and the bromo- fluorenes of 2--
1 part of 9- ketone, 1 part of trehalose, 1 part of lauryl dimethyl tertiary amine, 1 part of acrylate is well mixed, and is added to parallel dual-screw and matches somebody with somebody
Extruding pelletization in mixed extruder, the temperature setting of extruder is 120 DEG C, and screw speed is 460r/min, and charging rate is about
10g/min, water cooling is obtained degradable medical composite material, and after the granulation of Jing pelleters, be finally placed in 50 DEG C of baking ovens and dry
Do to constant mass.
Degradable medical composite material manufactured in the present embodiment, 60 days in the soil that relative humidity is 80% in automatically
Degraded, tensile strength 103Mpa, elongation at break 30%, bending strength 219Mpa.
Embodiment 3
A kind of degradable medical composite material, is made up of the raw material of following parts by weight：30 parts of polyvinyl acetate, poly- hydroxyl
30 parts of base fatty acid ester, 20 parts of starch, 90 parts of elm bast, 2 parts of Eupatorium adenophorum, 2 parts of paste of soap, tetramethylthiuram monosulfide
2 parts, 2 parts of TEGDMA, 5- hydroxyls -3 parts of 2 pentanone, 2 parts of pentaerythritol stearate.
The preparation method of above-mentioned degradable medical composite material, is carried out in accordance with the following steps：
(1) according to parts by weight, 30 parts of polyvinyl acetate is taken, 30 parts of polyhydroxyalkanoate, 20 parts of starch, elm bark is fine
90 parts of dimension, ultramicro grinding is mixed, and in being put into 1000 parts of ethanol, dispersion liquid is made in quick stirring；
(2) cauline leaf of Eupatorium adenophorum is taken, is dried, clayed into power, cross 200 mesh sieves, obtain Eupatorium adenophorum dry powder, take purple stem
2 parts of Herba Lycopi's dry powder, in being added to the dispersion liquid of step (1) preparation；
(3) the dispersion liquid room temperature volatilization for preparing step (2) is removed after ethanol, and with 2 parts of paste of soap, a sulfuration tetramethyl autumn is blue
2 parts of nurse, 2 parts of TEGDMA, 5- hydroxyls -3 parts of 2 pentanone, 2 parts of pentaerythritol stearate is well mixed,
Extruding pelletization in parallel dual-screw compounding extrusion machine is added to, the temperature setting of extruder is 150 DEG C, and screw speed is 500r/
Min, charging rate is about 15g/min, water cooling, is obtained degradable medical composite material, and after the granulation of Jing pelleters, finally
60 DEG C of drying in oven are placed in constant mass.
Degradable medical composite material manufactured in the present embodiment, 60 days in the soil that relative humidity is 80% in automatically
Degraded, tensile strength 111Mpa, elongation at break 31%, bending strength 231Mpa.
Embodiment 4
A kind of degradable medical composite material, is made up of the raw material of following parts by weight：25 parts of polyvinyl acetate, poly- hydroxyl
25 parts of base fatty acid ester, 15 parts of starch, 80 parts of fibre and soya, 1.5 parts of Eupatorium adenophorum, 1.5 parts of Macrogol 6000, floral leaf small stream
1.5 parts of tongue, 1.5 parts of diethyl phthalate, 1.5 parts of p-aminobenzoic acid, 2 parts of saualane, 1.5 parts of fatty acid distribution of coconut oil.
The preparation method of above-mentioned degradable medical composite material, is carried out in accordance with the following steps：
(1) according to parts by weight, 25 parts of polyvinyl acetate, 25 parts of polyhydroxyalkanoate, 15 parts of starch, fibre and soya 80
Part, ultramicro grinding is mixed, and in being put into 900 parts of ethanol, dispersion liquid is made in quick stirring；
(2) cauline leaf of Eupatorium adenophorum and floral leaf small stream tongue is taken, is dried, clayed into power, cross 180 mesh sieves, obtained Eupatorium adenophorum and do
Powder, takes 1.5 parts of Eupatorium adenophorum dry powder, 1.5 parts of floral leaf small stream tongue, in being added to the dispersion liquid of step (1) preparation；
(3) the dispersion liquid room temperature volatilization for preparing step (2) is removed after ethanol, with 1.5 parts of Macrogol 6000, adjacent benzene
1.5 parts of dicarboxylate, 1.5 parts of p-aminobenzoic acid, 2 parts of saualane, 1.5 parts of fatty acid distribution of coconut oil is well mixed, and is added to
Extruding pelletization in parallel dual-screw compounding extrusion machine, the temperature setting of extruder is 130 DEG C, and screw speed is 480r/min, plus
Material speed is about 12g/min, water cooling, is obtained degradable medical composite material, and after the granulation of Jing pelleters, be finally placed in 55
DEG C drying in oven is to constant mass.
Degradable medical composite material manufactured in the present embodiment, 45 days in the soil that relative humidity is 80% in automatically
Degraded, tensile strength 108Mpa, elongation at break 32%, bending strength 228Mpa.
Embodiment 2
A kind of degradable medical composite material, is made up of the raw material of following parts by weight：20 parts of polyvinyl acetate, poly- hydroxyl
20 parts of base fatty acid ester, 10 parts of starch, 10 parts of red crowned crane moss, 30 parts of corn stalk powder, 35 parts of wheat stalk powder, 1 part of Eupatorium adenophorum,
1 part of PEG 8000,1 part of the bromo- fluorenes -9- ketone of 2-, 1 part of trehalose, 1 part of lauryl dimethyl tertiary amine, 1 part of acrylate.
The preparation method of above-mentioned degradable medical composite material, is carried out in accordance with the following steps：
(1) according to parts by weight, 20 parts of polyvinyl acetate, 20 parts of polyhydroxyalkanoate, 10 parts of starch, maize straw are taken
30 parts of powder, 10 parts of red crowned crane moss, 35 parts of wheat stalk powder, ultramicro grinding is mixed, and in being put into 800 parts of ethanol, quick stirring is made point
Dispersion liquid；
(2) cauline leaf of Eupatorium adenophorum is taken, is dried, clayed into power, cross 150 mesh sieves, obtain Eupatorium adenophorum dry powder, take purple stem
1 part of Herba Lycopi's dry powder, in being added to the dispersion liquid of step (1) preparation；
(3) the dispersion liquid room temperature volatilization for preparing step (2) is removed after ethanol, and 1 part of PEG 8000, and the bromo- fluorenes of 2--
1 part of 9- ketone, 1 part of trehalose, 1 part of lauryl dimethyl tertiary amine, 1 part of acrylate is well mixed, and is added to parallel dual-screw and matches somebody with somebody
Extruding pelletization in mixed extruder, the temperature setting of extruder is 120 DEG C, and screw speed is 460r/min, and charging rate is about
10g/min, water cooling is obtained degradable medical composite material, and after the granulation of Jing pelleters, be finally placed in 50 DEG C of baking ovens and dry
Do to constant mass.
Degradable medical composite material manufactured in the present embodiment, 40 days in the soil that relative humidity is 80% in automatically
Degraded, tensile strength 103Mpa, elongation at break 30%, bending strength 219Mpa.
Comparative example 1
A kind of degradable medical composite material, is made up of the raw material of following parts by weight：25 parts of polyvinyl acetate, poly- hydroxyl
25 parts of base fatty acid ester, 15 parts of starch, 80 parts of fibre and soya, 1.5 parts of Macrogol 6000, diethyl phthalate 1.5
Part, 1.5 parts of p-aminobenzoic acid, 2 parts of saualane, 1.5 parts of fatty acid distribution of coconut oil.
The preparation method of above-mentioned degradable medical composite material, is carried out in accordance with the following steps：
(1) according to parts by weight, 25 parts of polyvinyl acetate, 25 parts of polyhydroxyalkanoate, 15 parts of starch, fibre and soya 80
Part, ultramicro grinding is mixed, and in being put into 900 parts of ethanol, dispersion liquid is made in quick stirring；
(3) the dispersion liquid room temperature volatilization for preparing step (1) is removed after ethanol, with 1.5 parts of Macrogol 6000, adjacent benzene
1.5 parts of dicarboxylate, 1.5 parts of p-aminobenzoic acid, 2 parts of saualane, 1.5 parts of fatty acid distribution of coconut oil is well mixed, and is added to
Extruding pelletization in parallel dual-screw compounding extrusion machine, the temperature setting of extruder is 130 DEG C, and screw speed is 480r/min, plus
Material speed is about 12g/min, water cooling, is obtained degradable medical composite material, and after the granulation of Jing pelleters, be finally placed in 55
DEG C drying in oven is to constant mass.
Degradable medical composite material manufactured in the present embodiment, 220 days in the soil that relative humidity is 80% in from
Dynamic degraded, tensile strength 108Mpa, elongation at break 32%, bending strength 228Mpa.
Embodiment 2
A kind of degradable medical composite material, is made up of the raw material of following parts by weight：20 parts of polyvinyl acetate, poly- hydroxyl
20 parts of base fatty acid ester, 10 parts of starch, 30 parts of corn stalk powder, 35 parts of wheat stalk powder, 1 part of Eupatorium adenophorum, polyethylene glycol
80001 parts, 1 part of trehalose, 1 part of lauryl dimethyl tertiary amine, 1 part of acrylate.
The preparation method of above-mentioned degradable medical composite material, is carried out in accordance with the following steps：
(1) according to parts by weight, 20 parts of polyvinyl acetate, 20 parts of polyhydroxyalkanoate, 10 parts of starch, maize straw are taken
30 parts of powder, 35 parts of wheat stalk powder, ultramicro grinding is mixed, and in being put into 800 parts of ethanol, dispersion liquid is made in quick stirring；
(2) cauline leaf of Eupatorium adenophorum is taken, is dried, clayed into power, cross 150 mesh sieves, obtain Eupatorium adenophorum dry powder, take purple stem
1 part of Herba Lycopi's dry powder, in being added to the dispersion liquid of step (1) preparation；
(3) the dispersion liquid room temperature volatilization for preparing step (2) is removed after ethanol, with 1 part of PEG 8000, trehalose 1
Part, 1 part of lauryl dimethyl tertiary amine, 1 part of acrylate is well mixed, is added to be extruded in parallel dual-screw compounding extrusion machine and makes
Grain, the temperature setting of extruder is 120 DEG C, and screw speed is 460r/min, and charging rate is about 10g/min, and water cooling is obtained
Degradable medical composite material, and after Jing pelleters granulation, be finally placed in 50 DEG C of drying in oven to constant mass.
Degradable medical composite material manufactured in the present embodiment, 60 days in the soil that relative humidity is 80% in automatically
Degraded, tensile strength 88Mpa, elongation at break 16%, bending strength 155Mpa.
Disclosed above is only the specific embodiment of the present invention, but, the present invention is not limited to this, any this area
What technical staff can think change should all fall into protection scope of the present invention.
Claims (8)
1. a kind of degradable medical composite material, it is characterised in that be made up of the raw material of following parts by weight：Polyvinyl acetate
20-30 parts, polyhydroxyalkanoate 20-30 parts, starch 10-20 parts, string 65-90 parts, Eupatorium adenophorum 1-2 parts, lubrication
Agent 1-2 parts, plasticizer 1-2 parts, antifreeze 1-2 parts, crosslinking agent 1-3 parts, waterproofing agent 1-2 parts.
2. degradable medical composite material according to claim 1, it is characterised in that the string is that soybean is fine
Dimension, corn stalk powder, wheat stalk powder, bark fiber, sisal fiber, ramee, the one kind or one kind in bamboo pulp fiber with
On.
3. degradable medical composite material according to claim 1, it is characterised in that the lubricant is polyethylene glycol
6000, PEG 8000, terpene polymer, one or more in paste of soap.
4. degradable medical composite material according to claim 1, it is characterised in that the plasticizer is phthalic acid
Diethylester, the bromo- fluorenes -9- ketone of 2-, benzoic acid, tetramethylthiuram monosulfide, 2- propyl enanthols, the one kind in isobutyl isobutyrate
Or more than one.
5. degradable medical composite material according to claim 1, it is characterised in that the antifreeze is p-aminophenyl first
Acid, mannitol, trehalose, sodium citrate, TEGDMA, the one kind or one kind in 3 Methylbutanoic acid butyl ester
More than.
6. degradable medical composite material according to claim 1, it is characterised in that the crosslinking agent is benzene three nitrogen of a pair of horses going side by side
Azoles, saualane, chromium acetate, lauryl dimethyl tertiary amine, a hydroxymethylphenol, dipotassium hydrogen phosphate, 5- hydroxyls -2 pentanone, 2- (2-
Butoxyethoxy) ethanol, one or more in asymmetric diisocyanate.
7. degradable medical composite material according to claim 1, it is characterised in that the waterproofing agent is coconut oil fat
Acid, stearic acid, glyceryl stearate, acrylate, 22 carbon -13- olefin(e) acids, octadecylisocyanate, pentaerythrite stearic acid
One or more in ester.
8. the preparation method of degradable medical composite material described in claim 1, it is characterised in that enter in accordance with the following steps
OK：
(1) according to parts by weight, polyvinyl acetate 20-30 parts are taken, polyhydroxyalkanoate 20-30 parts, starch 10-20 parts are planted
Fibres 65-90 parts, ultramicro grinding is mixed, and in being put into 800-1000 part ethanol, dispersion liquid is made in quick stirring；
(2) cauline leaf of Eupatorium adenophorum is taken, is dried, clayed into power, cross 150-200 mesh sieves, obtain Eupatorium adenophorum dry powder, take purple stem
Herba Lycopi's dry powder 1-2 part, in being added to the dispersion liquid of step (1) preparation；
(3) the dispersion liquid room temperature volatilization for preparing step (2) is removed after ethanol, and with lubricant 1-2 parts, plasticizer 1-2 parts are freeze proof
Agent 1-2 parts, crosslinking agent 1-3 parts, waterproofing agent 1-2 parts are well mixed, and are added to extruding pelletization in parallel dual-screw compounding extrusion machine,
The temperature setting of extruder is 120-150 DEG C, and screw speed is 460-500r/min, and charging rate is about 10-15g/min, water
Cooling, is obtained degradable medical composite material, and after the granulation of Jing pelleters, be finally placed in 50-60 DEG C of drying in oven to matter
Amount is constant.
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| CN101565537A (en) * | 2008-04-23 | 2009-10-28 | 深圳市莫廷影像技术有限公司 | Degradable pencil holder, pencil and fabricating method thereof |
| CN105237973A (en) * | 2015-09-30 | 2016-01-13 | 苏州蔻美新材料有限公司 | Polylactic acid-bacterial cellulose composite material and preparation method thereof |
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| CN1260813A (en) * | 1997-06-20 | 2000-07-19 | 生物技术生化学自然包装两合公司 | Disposable articles for military or pyrotechnic industries, non-folding roads, driving or walking aids made of biodegradable materials |
| CN1389517A (en) * | 2001-06-05 | 2003-01-08 | 段若新 | Plant fiber material product capable of being biodegraded completely and its making process |
| CN101565537A (en) * | 2008-04-23 | 2009-10-28 | 深圳市莫廷影像技术有限公司 | Degradable pencil holder, pencil and fabricating method thereof |
| CN105237973A (en) * | 2015-09-30 | 2016-01-13 | 苏州蔻美新材料有限公司 | Polylactic acid-bacterial cellulose composite material and preparation method thereof |
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