CN106620899A - 一种氧化石墨烯‑喹诺酮复合材料 - Google Patents

一种氧化石墨烯‑喹诺酮复合材料 Download PDF

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CN106620899A
CN106620899A CN201611167990.3A CN201611167990A CN106620899A CN 106620899 A CN106620899 A CN 106620899A CN 201611167990 A CN201611167990 A CN 201611167990A CN 106620899 A CN106620899 A CN 106620899A
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graphene oxide
parts
quinolone
composite
compound
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查林珍
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Wuzhong District Dome Mountain Carpenter New Material Technology Consulting Service Department
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/024—Carbon; Graphite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/424—Anti-adhesion agents

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Abstract

本发明公开了一种氧化石墨烯‑喹诺酮复合材料，具体而言，本发明的氧化石墨烯‑喹诺酮复合材料包含以重量份计的下列组分：氧化石墨烯50～80份、喹诺酮类化合物20～40份、二醇类化合物5～10份、吡啶1～5份和抗坏血酸4～7份。本发明的复合材料由氧化石墨烯、喹诺酮类化合物和二醇类连接桥段组成，用于抗细菌粘附、抑菌以及杀菌，具有较好的效果，并且结构简单，易于实施，可广泛应用于各类医用材料及器械。

Description

一种氧化石墨烯-喹诺酮复合材料
技术领域
本发明属于石墨烯材料技术领域，涉及一种氧化石墨烯-喹诺酮复合材料。
背景技术
近年来研究表明，在由生物材料引发的感染(BCI)中，大约一半的案例是由生物材料与人体接触后细菌感染造成的。传统抗菌材料的原理为接触杀菌或者缓慢释放杀菌，由于此类材料的寿命受到材料本身和缓释药物的影响很大，因此出现了以阻止细菌粘附为手段的抗菌模型，但这种抗菌模型也有其固有的问题，因此针对抗菌材料的改进始终是研发的热点。
发明内容
针对上述情况，本发明的目的在于提供一种氧化石墨烯-喹诺酮复合材料。
为了实现上述目的，本发明采用以下技术方案：
一种氧化石墨烯-喹诺酮复合材料，其包含以重量份计的下列组分：氧化石墨烯50～80份、喹诺酮类化合物20～40份、二醇类化合物5～10份、吡啶1～5份和抗坏血酸4～7份。
优选的，所述氧化石墨烯-喹诺酮复合材料包含以重量份计的下列组分：氧化石墨烯60～70份、喹诺酮类化合物25～35份、二醇类化合物6～9份、吡啶2～4和抗坏血酸5～6份。
更优选的，所述氧化石墨烯-喹诺酮复合材料包含以重量份计的下列组分：氧化石墨烯65份、喹诺酮类化合物30份、二醇类化合物7份、吡啶3和抗坏血酸5.5份。
优选的，在上述氧化石墨烯-喹诺酮复合材料中，所述氧化石墨烯通过Brodie法、Staudenmaier法或Hummers法制得。
优选的，在上述氧化石墨烯-喹诺酮复合材料中，所述喹诺酮类化合物选自诺氟沙星、氧氟沙星、环丙沙星、莫西沙星、加替沙星、克林沙星中的任意一种。
优选的，在上述氧化石墨烯-喹诺酮复合材料中，所述二醇类化合物选自乙二醇、1,3-丙二醇、1,4-丁二醇、1,3-环戊二醇、1,4-环己二醇中的任意一种。
与现有技术相比，采用上述技术方案的本发明具有以下优点：本发明的复合材料由氧化石墨烯、喹诺酮类化合物和二醇类连接桥段组成，用于抗细菌粘附、抑菌以及杀菌，具有较好的效果，并且结构简单，易于实施，可广泛应用于各类医用材料及器械。
具体实施方式
下面实施例将进一步举例说明本发明。这些实施例仅用于说明本发明，但不以任何方式限制本发明。
实施例1：氧化石墨烯-喹诺酮复合材料的生产。
本实施例的氧化石墨烯-喹诺酮复合材料包含下列组分：氧化石墨烯(经Hummers法制得)50kg、诺氟沙星20kg、乙二醇5kg、吡啶1kg和抗坏血酸4kg。上述组分经混合后于100～120℃搅拌反应2～4小时，得到氧化石墨烯-喹诺酮复合材料。
实施例2：氧化石墨烯-喹诺酮复合材料的生产。
本实施例的氧化石墨烯-喹诺酮复合材料包含下列组分：氧化石墨烯(经Hummers法制得)80kg、氧氟沙星40kg、1,3-丙二醇10kg、吡啶5kg和抗坏血酸7kg。上述组分经混合后于100～120℃搅拌反应2～4小时，得到氧化石墨烯-喹诺酮复合材料。
实施例3：氧化石墨烯-喹诺酮复合材料的生产。
本实施例的氧化石墨烯-喹诺酮复合材料包含下列组分：氧化石墨烯(经Staudenmaier法制得)60kg、环丙沙星25kg、1,4-丁二醇6kg、吡啶2kg和抗坏血酸5kg。上述组分经混合后于100～120℃搅拌反应2～4小时，得到氧化石墨烯-喹诺酮复合材料。
实施例4：氧化石墨烯-喹诺酮复合材料的生产。
本实施例的氧化石墨烯-喹诺酮复合材料包含下列组分：氧化石墨烯(经Staudenmaier法制得)70kg、莫西沙星35kg、1,3-环戊二醇9kg、吡啶4kg和抗坏血酸6kg。上述组分经混合后于100～120℃搅拌反应2～4小时，得到氧化石墨烯-喹诺酮复合材料。
实施例5：氧化石墨烯-喹诺酮复合材料的生产。
本实施例的氧化石墨烯-喹诺酮复合材料包含下列组分：氧化石墨烯(经Brodie法制得)65kg、加替沙星30kg、1,4-环己二醇7kg、吡啶3kg和抗坏血酸5.5kg。上述组分经混合后于100～120℃搅拌反应2～4小时，得到氧化石墨烯-喹诺酮复合材料。
前述对本发明的具体示例性实施方案的描述是为了说明和例证的目的。这些描述并非想穷尽本发明，或者将本发明限定为所公开的精确形式；相反，根据上述教导，可以进行很多改变和变化。对示例性实施例进行选择和描述的目的在于解释本发明的特定原理及其实际应用，从而使得本领域的其它技术人员能够实现并利用本发明的各种不同的示例性实施方案以及各种不同的选择和改变。本发明的范围旨在由所附的权利要求书及其等同形式所限定。

Claims (6)

1.一种氧化石墨烯-喹诺酮复合材料，其包含以重量份计的下列组分：氧化石墨烯50～80份、喹诺酮类化合物20～40份、二醇类化合物5～10份、吡啶1～5份和抗坏血酸4～7份。
2.根据权利要求1所述的氧化石墨烯-喹诺酮复合材料，其特征在于，所述氧化石墨烯-喹诺酮复合材料包含以重量份计的下列组分：氧化石墨烯60～70份、喹诺酮类化合物25～35份、二醇类化合物6～9份、吡啶2～4和抗坏血酸5～6份。
3.根据权利要求2所述的氧化石墨烯-喹诺酮复合材料，其特征在于，所述氧化石墨烯-喹诺酮复合材料包含以重量份计的下列组分：氧化石墨烯65份、喹诺酮类化合物30份、二醇类化合物7份、吡啶3和抗坏血酸5.5份。
4.根据权利要求1至3中任一项所述的氧化石墨烯-喹诺酮复合材料，其特征在于，所述氧化石墨烯通过Brodie法、Staudenmaier法或Hummers法制得。
5.根据权利要求1至3中任一项所述的氧化石墨烯-喹诺酮复合材料，其特征在于，所述喹诺酮类化合物选自诺氟沙星、氧氟沙星、环丙沙星、莫西沙星、加替沙星、克林沙星中的任意一种。
6.根据权利要求1至3中任一项所述的氧化石墨烯-喹诺酮复合材料，其特征在于，所述二醇类化合物选自乙二醇、1,3-丙二醇、1,4-丁二醇、1,3-环戊二醇、1,4-环己二醇中的任意一种。
CN201611167990.3A 2016-12-16 2016-12-16 一种氧化石墨烯‑喹诺酮复合材料 Pending CN106620899A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110075615A (zh) * 2019-04-17 2019-08-02 南通强生石墨烯科技有限公司 一种复合净水滤芯及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103191464A (zh) * 2013-04-07 2013-07-10 西南交通大学 一种抗菌多孔氧化石墨烯/壳聚糖复合支架的制备方法
CN104072809A (zh) * 2014-06-20 2014-10-01 南京林业大学 一种氧化石墨烯/细菌纤维素抗菌复合材料的制备方法
CN104189910A (zh) * 2014-08-13 2014-12-10 浙江大学 一种用于药物缓释的氧化石墨烯薄膜制备方法以及产品

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103191464A (zh) * 2013-04-07 2013-07-10 西南交通大学 一种抗菌多孔氧化石墨烯/壳聚糖复合支架的制备方法
CN104072809A (zh) * 2014-06-20 2014-10-01 南京林业大学 一种氧化石墨烯/细菌纤维素抗菌复合材料的制备方法
CN104189910A (zh) * 2014-08-13 2014-12-10 浙江大学 一种用于药物缓释的氧化石墨烯薄膜制备方法以及产品

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110075615A (zh) * 2019-04-17 2019-08-02 南通强生石墨烯科技有限公司 一种复合净水滤芯及其制备方法

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Application publication date: 20170510