CN106620834A - Styptic powder dressing and preparation method thereof - Google Patents

Styptic powder dressing and preparation method thereof Download PDF

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Publication number
CN106620834A
CN106620834A CN201710070013.XA CN201710070013A CN106620834A CN 106620834 A CN106620834 A CN 106620834A CN 201710070013 A CN201710070013 A CN 201710070013A CN 106620834 A CN106620834 A CN 106620834A
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China
Prior art keywords
starch
parts
powder dressing
styptic
preparation
Prior art date
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Pending
Application number
CN201710070013.XA
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Chinese (zh)
Inventor
李延浩
杨帅
袁召
周新钦
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Henan Huibo Medical Co Ltd
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Henan Huibo Medical Co Ltd
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Priority to CN201710070013.XA priority Critical patent/CN106620834A/en
Publication of CN106620834A publication Critical patent/CN106620834A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/009—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/206—Biguanides, e.g. chlorohexidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/208—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention discloses a styptic powder dressing and a preparation method thereof. The styptic powder dressing is prepared from, by weight, 8.5-9.5 parts of micro-porous starch, 5-10 parts of galactomannan, 0.1-0.5 part of CaCl2 and 0.01-0.1 part of antibacterial agents. Compared with the prior art, the styptic powder dressing has the advantages that plant starch serving as a raw material is treated by composite enzymatic hydrolysis-hydrophilic modification-granulation joint technology to obtain a styptic material, the hygroscopic property and 'transient dissolubility' of products are improved, gel can be formed within a short time after the styptic material contacts with blood, blood platelets are enriched, the purpose of rapid hemostasis is achieved, besides, composite Ca ions can achieve double effects of physiological hemostasis, the material has absorbability and excellent biocompatibility, the styptic powder dressing is degraded within 7 days and high in safety, the raw material is wide in source and low in cost, and the styptic powder dressing has an antibacterial performance and is more protective when used for wounds.

Description

One kind hemostasis powder dressing and preparation method thereof
Technical field
The invention belongs to medical dressing field, particularly to a kind of hemostasis powder dressing and preparation method thereof.
Background technology
Surgical hemostasis are one of cores of surgical technic, and good hemostatic technique is the key for ensureing successful surgery, with Various countries' medical circle finds biomaterial excellent in nature, exploitation to hemostatic material validity and the raising of security requirement Go out haemostatic effect more preferably, have no toxic side effect, hemostatic material nonirritant, easily processed into type, it is imperative；Existing styptic powder Body dressing casting product defect：Haemostatic effect is poor：Show that water absorption is few, viscosity is low, poor adhesion；Stability is poor；Starch is easy In microorganism microbiological contamination；Shitosan is originated：Degradability is poor, there is security risk；Such as the China of Application No. 200910016401.5 Patent, its shortcoming is：1st, shitosan defect degraded allergy risk, 2, starch absorbability itself it is limited, viscosity is low, product hemostasis imitate Fruit is affected 3, not antibacterial；For another example the Chinese patent of Application No. 200810032631.6, its shortcoming is：1. product starch- The technique of modified-granulation is made, steady after its irradiation sterilization with water as adhesive in low 2. granulation of the few viscosity of the few water absorption rate in space Qualitative difference, the bonding force between particle is weak, and depolymerization is easy in long-term Conservation environment, affects properties of product 3. single, without secondary Hemostatic function component 4. is easy to microbiological contamination without antibacterial ability, starch, is not suitable for external hemostasis；And for example Application No. 201110056742.2 Chinese patent, its shortcoming is：1st, starch absorbability is limited, and 2, without antibacterial ability；For another example Application No. 201110316690.8 Chinese patent, its shortcoming is：Not antibacterial；For another example the China of Application No. 201110073208.2 is special Profit, its shortcoming is：Although the 1, antibacterial 2, micropore does not improve absorbability, viscosity is low, low to the adhesive force of the surface of a wound；It is and for example beautiful State's patent US6060461, it has used epichlorohydrin as crosslinking agent in preparation process, and this material is colourless oil liquid, is had Toxicity and narcoticness, have potentially hazardous to human body；From on haemostatic effect, water absorbent rate is low, and absorption speed is slow, haemostatic effect It is not satisfactory, it is especially not good enough to active hemorrhage haemostatic effect；The gel viscosity formed after water suction is poor, it is impossible to damaged group Knit, blood vessel produces effective viscosity closure, in active hemorrhage, styptic powder is difficult to be attached at bleeding, is easily washed away by blood flow, If being pressed with auxiliary material on styptic powder, auxiliary material is easy to by sludged blood adhesion, and bleeding again is easily caused when opening auxiliary material, because This, it is not satisfactory to active hemorrhage effect and expensive.
The content of the invention
The present invention seeks to be directed to above-mentioned the deficiencies in the prior art and provide a kind of hemostasis powder dressing and preparation method thereof.
To solve above-mentioned technical problem, the technical solution adopted in the present invention is：One kind hemostasis powder dressing, it be by with The raw material of lower parts by weight is prepared from, micropore starch 8.5-9.5 parts, galactomannans 5-10 parts, CaCl2 0.1-0.5 Part, antiseptic 0.01-0.1 parts.
Above-mentioned micropore starch takes from any one in farina, cornstarch, wheaten starch.
Above-mentioned antiseptic is taken from any one in hexamethylene, organosilicon quaternary ammonium salt or chlorhexidine acetate Kind.
A kind of method for preparing above-mentioned hemostasis powder dressing, the method comprising the steps of：
（1）The preparation of micropore starch
Any one starch in farina, cornstarch or wheaten starch is taken, answering for above-mentioned starch quality 1%-5% is added Synthase, the stirring enzymolysis in the container that temperature is 30 DEG C -50 DEG C forms micropore starch, and wherein complex enzyme is by AMS, general Shandong orchid enzyme and carbohydrase are 1 according to mass ratio:2:2. ratio synthesis；
（2）Carboxylated is hydrophilically modified
It is hydrophilically modified that porous-starch to digesting carries out carboxymethyl, using ultrasonically treated in modified-reaction, is modified with improving it Substitution value；
（3）Granulation
Starch after hydrophilic modifying is pelletized using fluid bed granulator, the granular size of preparation is 0.1 μm -1000 μm, system Add by galactomannans, CaCl during grain2, the adhesive prepared of antimicrobial；
（4）Irradiation sterilization
After styptic powder after granulation is packed, using Co60 irradiation sterilizations, irradiation dose is 15-25KGy.
Hemostasis powder dressing prepared by the present invention, has the advantages that compared with prior art：1st, the present invention with Plant amylum is that raw material obtains hemostatic material using complex enzyme hydrolysis-hydrophilic modification-granulation United Technologies process, improves product Water imbibition and " wink dissolubility " contact blood after can performance gel at short notice, be enriched with blood platelet, reach quick-acting haemostatic powder purpose. Simultaneously complex Ca ion can also play the double effectses of physiological haemostasis；2nd, material of the invention possesses absorbability, biofacies Capacitive is excellent；3rd, the present invention degrades in 7 days, safe；4th, raw material sources of the invention are extensively, with low cost；5th, the present invention Possess anti-microbial property, more protect for wound.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical scheme will be carried out below Clear, complete description.
Embodiment 1
The hemostasis powder dressing of the present invention is prepared from by the raw material of following parts by weight, 8.8 parts of farina, and gala is sweet 6 parts of glycan of dew, CaCl20.2 part, 0.03 part of hexamethylene bis guanidine hydrochloride.
The preparation method of above-mentioned hemostasis powder dressing is comprised the following steps：
（1）The preparation of micropore starch
Any one starch in farina, cornstarch or wheaten starch is taken, answering for above-mentioned starch quality 1%-5% is added Synthase, the stirring enzymolysis in the container that temperature is 30 DEG C -50 DEG C forms micropore starch, and wherein complex enzyme is by AMS, general Shandong orchid enzyme and carbohydrase are 1 according to mass ratio:2:2. ratio synthesis；
（2）Carboxylated is hydrophilically modified
It is hydrophilically modified that porous-starch to digesting carries out carboxymethyl, using ultrasonically treated in modified-reaction, is modified with improving it Substitution value；
（3）Granulation
Starch after hydrophilic modifying is pelletized using fluid bed granulator, the granular size of preparation is 0.1 μm -1000 μm, system Add by galactomannans, CaCl during grain2, the adhesive prepared of antimicrobial；
（4）Irradiation sterilization
After styptic powder after granulation is packed, using Co60 irradiation sterilizations, irradiation dose is 15-25KGy.
Embodiment 2
The hemostasis powder dressing of the present invention is prepared from by the raw material of following parts by weight, and 9 parts of cornstarch, galactomannan gathers 6 parts of sugar, CaCl20.3 part, 0.06 part of organosilicon quaternary ammonium salt, its preparation method is with embodiment 1.
Embodiment 3
The hemostasis powder dressing of the present invention is prepared from by the raw material of following parts by weight, 9.4 parts of wheaten starch, galactomannan 9 parts of glycan, CaCl20.4 part, 0.08 part of chlorhexidine acetate, its preparation method is with embodiment 1.

Claims (4)

1. a kind of hemostasis powder dressing, it is characterised in that：It is prepared from by the raw material of following parts by weight, micropore starch 8.5-9.5 parts, galactomannans 5-10 parts, CaCl2 0.1-0.5 parts, antiseptic 0.01-0.1 parts.
2. hemostasis powder dressing according to claim 1, it is characterised in that：The micropore starch take from farina, Any one in cornstarch, wheaten starch.
3. hemostasis powder dressing according to claim 1, it is characterised in that：The antiseptic takes from poly hexamethylene biguanide Any one in hydrochloride, organosilicon quaternary ammonium salt or chlorhexidine acetate.
4. a kind of method for preparing as claimed in claim 1 hemostasis powder dressing, it is characterised in that：Methods described includes following step Suddenly：
（1）The preparation of micropore starch
Any one starch in farina, cornstarch or wheaten starch is taken, answering for above-mentioned starch quality 1%-5% is added Synthase, the stirring enzymolysis in the container that temperature is 30 DEG C -50 DEG C forms micropore starch, and wherein complex enzyme is by AMS, general Shandong orchid enzyme and carbohydrase are 1 according to mass ratio:2:2 ratio synthesis；
（2）Carboxylated is hydrophilically modified
It is hydrophilically modified that porous-starch to digesting carries out carboxymethyl, using ultrasonically treated in modified-reaction, is modified with improving it Substitution value；
（3）Granulation
Starch after hydrophilic modifying is pelletized using fluid bed granulator, the granular size of preparation is 0.1 μm -1000 μm, system Add by galactomannans, CaCl during grain2, the adhesive prepared of antimicrobial；
（4）Irradiation sterilization
After styptic powder after granulation is packed, using Co60 irradiation sterilizations, irradiation dose is 15-25KGy.
CN201710070013.XA 2017-02-09 2017-02-09 Styptic powder dressing and preparation method thereof Pending CN106620834A (en)

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Application Number Priority Date Filing Date Title
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107929795A (en) * 2017-11-16 2018-04-20 北京华信佳音医疗科技发展有限责任公司 A kind of preparation and its application of antibacterial anti hemorrhagic material
CN109010897A (en) * 2018-09-08 2018-12-18 佛山市森昂生物科技有限公司 A kind of preparation method of medical antibacterial gel dressing
CN113068401A (en) * 2019-10-31 2021-07-02 株式会社三养生物制药 Powder type hemostatic composition and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102327601A (en) * 2011-09-26 2012-01-25 西北大学 Hemostat for resisting infection and promoting wound healing and preparation method thereof
CN102526794A (en) * 2012-01-19 2012-07-04 华东理工大学 Calcium-complex starch-based microporous haemostatic material, and preparation method and application thereof
WO2016100861A1 (en) * 2014-12-19 2016-06-23 Baxter International, Inc. Flowable hemostatic composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102327601A (en) * 2011-09-26 2012-01-25 西北大学 Hemostat for resisting infection and promoting wound healing and preparation method thereof
CN102526794A (en) * 2012-01-19 2012-07-04 华东理工大学 Calcium-complex starch-based microporous haemostatic material, and preparation method and application thereof
WO2016100861A1 (en) * 2014-12-19 2016-06-23 Baxter International, Inc. Flowable hemostatic composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
傅亚等: ""酶法制备玉米微孔淀粉比较研究"", 《食品科技》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107929795A (en) * 2017-11-16 2018-04-20 北京华信佳音医疗科技发展有限责任公司 A kind of preparation and its application of antibacterial anti hemorrhagic material
CN109010897A (en) * 2018-09-08 2018-12-18 佛山市森昂生物科技有限公司 A kind of preparation method of medical antibacterial gel dressing
CN113068401A (en) * 2019-10-31 2021-07-02 株式会社三养生物制药 Powder type hemostatic composition and preparation method thereof

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Application publication date: 20170510