CN106619157A - Anti-caries anti-allergic purified water and preparing method thereof - Google Patents
Anti-caries anti-allergic purified water and preparing method thereof Download PDFInfo
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- CN106619157A CN106619157A CN201710026948.8A CN201710026948A CN106619157A CN 106619157 A CN106619157 A CN 106619157A CN 201710026948 A CN201710026948 A CN 201710026948A CN 106619157 A CN106619157 A CN 106619157A
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- pure water
- antiallergic
- decayed tooth
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- purified water
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses an anti-caries anti-allergic purified water and a preparing method thereof. The purified water is prepared from, by weight, 8%-15% of humectant, 1%-3% of surface active agent, 0.1%-0.3% of sweetening agent, 0.1%-0.3% of edible antiseptic, 0.08%-0.2% of freshener, 0.0001%-0.0002% of pigment, 0.02%-0.06% of ammonium silicofluoride and the balance deionized water. According to the anti-caries anti-allergic purified water and the preparing method thereof, ammonium silicofluoride is added into the purified water as a functional material, compared with the current mineral water or purified water, the anti-caries anti-allergic purified water is more obvious in anti-allergic efficacy, good in mouthfeel, free from ethyl alcohol, which reduces the carcinogenic danger of ethyl alcohol, and more safe, does not generate side-effects of tooth discoloration and the like, has the effects of both anti-caries and sterilization, and can maintain oral health.
Description
Technical field
The present invention relates to a kind of oral health care product, more particularly to a kind of preventing decayed tooth antiallergic pure water and preparation method thereof.
Background technology
Hyperesthesia of dentin is the common disease in mouth disease, one of frequently-occurring disease, due to it is hot and cold, mechanically or chemically pierce
Can cause the sharp pain of patient in the case of swashing, directly influence the quality of life of patient.
Dental caries are one of the three big diseases for endangering human health, are hard tooth tissues in many factors shadow based on bacterium
Ring lower generation inorganic matter demineralization, organic matter to decompose, produce color (chalk color, yellowish-brown, pitchy), shape (defect cavitation), matter and (dredge
Softization) aspect change chronic progressive external destruction disease.
Pure water common at present, due to removing most of mineral matter, lacks preventing decayed tooth antiallergic effect.The conventional ore deposit of another kind
Spring, generally comprises only needed by human body mineral matter, also without preventing decayed tooth antiallergic effect.
For the preventing decayed tooth antiallergic of tooth, in recent years various preventing decayed tooth antiallergic sense toothpaste and mouthwash occur in succession, example
Mouthwash such as containing sodium fluoride or potassium ion, they are by blocking dentinal tubule or making nerve depolarization de- to reach
Quick effect.But during due to using they in the oral cavity residence time section it is short, be just rinsed immediately, and dentine
Allergy itself is again that a kind of reason is complicated, is easy to the disease of recurrence, therefore the effect of its anti-dentine hypersensitivity is not notable.
Ammonium hexafluorosilicate, chemical formula is（NH4）2SiF6, is abbreviated as SiF, be typically used as at present brewery industry disinfectant,
Glass etching agent, the mothproofing agent of textile, timber preservative, are also used for light metal casting, plating, are additionally operable to by carrying potassium in greensand
And produce cryolith and ammonium chlorate etc..Hu Chenghua of Xiangya Hospital, Central-South China Univ. etc. is studied and to report it little to dentine
The sealing process of pipe, this report is tested in vitro dentine disk, adopts single concentration for 0.476mol/L i.e. quality
Percentage composition is that 8.48% ammonium hexafluorosilicate is tested, and shows concrete preferably Effect of Dental Tubule Seal After.
The content of the invention
The purpose of the present invention：A kind of preventing decayed tooth antiallergic pure water and preparation method thereof is provided, anti-dentine hypersensitivity excellent effect,
There is certain anti-caries effect.
To achieve these goals, the technical scheme is that：
A kind of preventing decayed tooth antiallergic pure water, including following components in percentage by weight：The NMF of 8-15%, the surface-active of 1-3%
Agent, the sweetener of 0.1-0.3%, the food antiseptics of 0.1-0.3%, the freshener of 0.08-0.2%, the color of 0.0001-0.0002%
The deionized water of element, the ammonium hexafluorosilicate of 0.02-0.06% and surplus.
Above-mentioned preventing decayed tooth antiallergic pure water, wherein, the Funing tablet of described preventing decayed tooth antiallergic pure water is maintained at 0.7-1mg/L
Within.
Above-mentioned preventing decayed tooth antiallergic pure water, wherein, the concentration of described ammonium hexafluorosilicate is 0.02%.
Above-mentioned preventing decayed tooth antiallergic pure water, wherein, described preventing decayed tooth antiallergic pure water also includes that percentage by weight is 0.03-
0.05% cetylpyridinium chloride(CPC).
Above-mentioned preventing decayed tooth antiallergic pure water, wherein, the concentration of described cetylpyridinium chloride(CPC) is 0.03%.
A kind of preparation method of preventing decayed tooth antiallergic pure water, wherein, the method at least comprises the steps：
Step 1：Prevented with the NMF of 8-15%, the surfactant of 1-3%, the sweetener of 0.1-0.3%, the edible of 0.1-0.3%
The deionized water of rotten agent, the freshener of 0.08-0.2% and surplus prepares pure water.
Step 2：Fluorine is added in pure water.
Step 3：Fluorine and pure water are well mixed, the ammonium hexafluorosilicate of 0.02-0.06%, 0.03-0.05% is added
The pigment of cetylpyridinium chloride(CPC) and 0.0001-0.0002%, continues to stir, and after all materials are well mixed, stops stirring.
Step 4：During the material-filling being well mixed to be entered the glass or plastic containers of lucifuge, finished product is finally obtained.
The present invention is added to ammonium hexafluorosilicate as feature material in pure water, with existing mineral water or pure water
Compare, effect of antiallergic sense is more notable；It is in good taste；And not spirituosity, the carcinogenic danger of alcohol is reduced, it is safer；Do not produce
The side effects such as raw tooth discoloration；Also there is the effect of preventing decayed tooth and sterilization simultaneously, oral health can be preferably safeguarded.
Description of the drawings
Fig. 1 is the flow chart of the preparation method of preventing decayed tooth antiallergic pure water of the present invention.
Specific embodiment
Embodiments of the invention are further illustrated below in conjunction with accompanying drawing.
Embodiment 1：
A kind of preventing decayed tooth antiallergic pure water, including following components in percentage by weight：The NMF of 8-15%, the surface-active of 1-3%
Agent, the sweetener of 0.1-0.3%, the food antiseptics of 0.1-0.3%, the freshener of 0.08-0.2%, the color of 0.0001-0.0002%
The deionized water of element, the ammonium hexafluorosilicate of 0.02-0.06% and surplus.
The suitable Funing tablet of described preventing decayed tooth antiallergic pure water typically should be maintained within 0.7-1mg/L.
Described preventing decayed tooth antiallergic pure water also includes cetylpyridinium chloride(CPC) of the percentage by weight for 0.03-0.05%.Chlorination
Hexadecane pyridine is typically used for oral antimicrobial composition and uses, and cetylpyridinium chloride(CPC) is used cooperatively with ammonium hexafluorosilicate, can be with
Obvious synergistic function is reached so that antiallergic effect strengthens, while having preferable anticaries action.
Refer to shown in accompanying drawing 1, a kind of preparation method of preventing decayed tooth antiallergic pure water, the method at least comprises the steps：
Step 1：Prevented with the NMF of 8-15%, the surfactant of 1-3%, the sweetener of 0.1-0.3%, the edible of 0.1-0.3%
The deionized water of rotten agent, the freshener of 0.08-0.2% and surplus prepares pure water.
Step 2：Fluorine is added in pure water.
Step 3：Fluorine and pure water are well mixed, the ammonium hexafluorosilicate of 0.02-0.06%, 0.03-0.05% is added
The pigment of cetylpyridinium chloride(CPC) and 0.0001-0.0002%, continues to stir, and after all materials are well mixed, stops stirring.
Step 4：During the material-filling being well mixed to be entered the glass or plastic containers of lucifuge, finished product is finally obtained.
Embodiment 2：
Step 1：Prevented with the NMF of 8-15%, the surfactant of 1-3%, the sweetener of 0.1-0.3%, the edible of 0.1-0.3%
The deionized water of rotten agent, the freshener of 0.08-0.2% and surplus prepares pure water.
Step 2：Fluorine is added in pure water.
Step 3：Fluorine and pure water are well mixed, 0.02% ammonium hexafluorosilicate, the color of 0.0001-0.0002% is added
Element, continues to stir, and after all materials are well mixed, stops stirring.
Step 4：During the material-filling being well mixed to be entered the glass or plastic containers of lucifuge, finished product is finally obtained.
Embodiment 3：
Step 1：Prevented with the NMF of 8-15%, the surfactant of 1-3%, the sweetener of 0.1-0.3%, the edible of 0.1-0.3%
The deionized water of rotten agent, the freshener of 0.08-0.2% and surplus prepares pure water.
Step 2：Fluorine is added in pure water.
Step 3：Fluorine and pure water are well mixed, 0.02% ammonium hexafluorosilicate, 0.03% Cetylpyridinium chloride is added
The pigment of pyridine and 0.0001-0.0002%, continues to stir, and after all materials are well mixed, stops stirring.
Step 4：During the material-filling being well mixed to be entered the glass or plastic containers of lucifuge, finished product is finally obtained.
Embodiment 4：
The suitable Funing tablet of fluorine drinking-water typically should be maintained within 0.7～1mg/L.
Step 1：With the NMF of 8-15%, the surfactant of 1-3%, the sweetener of 0.1-0.3%, 0.1-0.3% food
Pure water is prepared with the deionized water of preservative, the freshener of 0.08-0.2% and surplus.
Step 2：Fluorine is added in pure water.
Step 3：Fluorine and pure water are well mixed, 0.02% ammonium hexafluorosilicate, 0.03% Cetylpyridinium chloride is added
The pigment of pyridine and 0.0001-0.0002%, continues to stir, and after all materials are well mixed, stops stirring.
Step 4：During the material-filling being well mixed to be entered the glass or plastic containers of lucifuge, finished product is finally obtained.
Embodiment 5：
Crowd observes：The people of volunteer 20, is randomly divided into two groups, respectively with ammonium hexafluorosilicate of the present invention（Abbreviation SiF groups, its is pure
The composition of water is consistent with the embodiment of the present invention 4）Pure water, placebo（Abbreviation control group）Preventing decayed tooth clinical observation in 4 weeks by a definite date is carried out,
Observed content is the percentage that streptococcus mutans accounts for total anaerobic bacteria before and after experiment.The results are shown in Table 1：
The preventing decayed tooth experimental result of table 1
| Before experiment | After experiment | P values | |
| Control group | 24.0 | 22.5 | 0.053 |
| SiF groups | 22.6 | 9.9 | <0.01 |
Being statistically analyzed result before and after SiF groups experiment of the present invention has significant difference, and this shows that SiF mouthwashes of the present invention can be bright
It is aobvious to suppress the growth of streptococcus mutans in bacterial plaque, and play the role of specific preventing decayed tooth, substantial amounts of basic research have also demonstrated six
Ammonium fluosilicate can induce the generation of fluor-apatite, promote the effect of remineralization.
Embodiment 6：Antiallergic is tested
Crowd observes：Filter out the people of volunteer 60 with hyperesthesia of dentin（Everyone at least more than two sensitive teeths）, with
Machine is divided into six groups, respectively with the ammonium hexafluorosilicate of the present invention of variable concentrations（Abbreviation SiF groups, composition and the present invention of its pure water
Embodiment 4 is consistent）Pure water, placebo（Abbreviation control group）Carry out antiallergic sense clinical observation in 4 weeks by a definite date.
Observed content is that antiallergic sense is efficient.
Observation index：Using a kind of subjective evaluation method-VAS (the visual analogue scale) methods of pain come
Evaluate sensitivity.Concrete grammar is:The straight line of one long 10 cm, one end is 0, is represented not bitterly;The other end is 10, represents play
Bitterly;The sensitivity that it suffers from tooth is marked on straight line by patient.1) impose 40 g weight with a probe to examine in sensitive part spy
When pressure test VAS values.2) adjacent teeth is isolated with lap, the vertical and cm of distance sensitive face 1 is entered with Three-way syringe for dentistry to suffering from tooth
Row cold air (4p. s. i, 19～24 DEG C) stimulates the temperature test VAS values after 1 s.3) record uses SiF mouthwashes four
Pressure, temperature test VAS values after week at once.
Suffer from the VAS values of tooth pressure test and temperature test with before treatment as baseline, two indexes reduce by more than 75% after treatment
Person is effective, and it is invalid to reduce less than 25%, and remaining is effective.Efficient (%)=(effective tooth number+effective tooth number)/
Total tooth number × 100%.
As a result 2 be see the table below：
Table 2：Antiallergic experimental result
| Title | SiF consumptions（Account for the percentage by weight of water inventory of gargling） | Anti- sensitizing effect（Surrounding） |
| Control group | SiF：0% | Antiallergic sense efficient 28% |
| SiF groups 1 | SiF：0.02% | Antiallergic sense efficient 51% |
| SiF groups 2 | SiF：0.03% | Antiallergic sense efficient 72% |
| SiF groups 3 | SiF：0.04% | Antiallergic sense efficient 79% |
| SiF groups 4 | SiF：0.05% | Antiallergic sense efficient 86% |
| SiF groups 5 | SiF：0.06% | Antiallergic sense efficient 75% |
By above-mentioned contrast test, further illustrate the pure water antiallergic sense containing SiF of the invention it is efficient on notable work(
Effect, and determine SiF consumptions（Account for the percentage by weight of water inventory of gargling）Optimal dose is 0.05%.
Embodiment 7：The above embodiments 1-4 are respectively adopted carries out respectively preventing decayed tooth antiallergic experiment
It is above-mentioned during the pure water of SiF and cetylpyridinium chloride(CPC) is defined as " blank pure water " and the present invention below by way of being not added with
Embodiment 1（It is defined as " pure water 1 "）, embodiment 2（It is defined as " pure water 2 "）, embodiment 3（It is defined as " pure water 3 "）, it is real
Apply example 4（It is defined as " pure water 4 "）The formula of preventing decayed tooth antiallergic pure water compare test, further illustrate preventing decayed tooth of the present invention
The effect of antiallergic pure water in preventing decayed tooth antiallergic.Crowd observes：Filter out the people of volunteer 60 with hyperesthesia of dentin（Everyone
At least more than two sensitive teeths）, it is randomly divided into five groups（Other particular contents are tested with the antiallergic of the embodiment of the present invention 5）, knot
Fruit is shown in Table 3.
The antiallergic Experimental comparison's table of table 3
The above results show that the pure water antiallergic effect of the present invention is obvious, and is used in conjunction with SiF using cetylpyridinium chloride(CPC)
Afterwards, there is obvious Synergistic preventing decayed tooth antiallergic to act on for the two.
The present invention has carried out a large amount of isolated experiments and clinical testing, using conjunction under current basic research theoretical direction
Suitable hexafluorosilicic acid ammonium concentration, and with the use of other auxiliary materials.
Ammonium hexafluorosilicate is applied to the main active of pure water by the present invention first, and further with chlorination 16
Alkane pyridine compatibility is used；From the security consideration of pure water, the present invention matches somebody with somebody for ammonium hexafluorosilicate to related conventional pure water
The situation that conjunction is used, has carried out substantial amounts of toxicology and pharmacology experiment, and also the pure water to further adding cetylpyridinium chloride(CPC) enters
Substantial amounts of toxicology and pharmacology of having gone is tested, and experiment shows, do not repel each other reaction between the formula components of the present invention, and prolonged application is also
Non-toxic and safe.
Because ammonium hexafluorosilicate can promote the formation of silica calcium phosphate, stronger blocking dentinal tubule is played
Effect, and resistivity of the tooth to acid can also be strengthened, dentin ferrule is reduced, make so as to play stronger antiallergic sense
With.
For the concentration that ammonium hexafluorosilicate is used as pure water functional component, the present invention is on the basis of existing basic research
On, it is considered to the problem of valid density and toxic dose, through many experiments, it is determined that the concentration range of 0.02-0.06%, so as to
While ensureing preferable antiallergic effect, in the case where being used for multiple times daily, to body without health hazard.
In sum, the present invention is added to ammonium hexafluorosilicate as feature material in pure water, with existing mineral spring
Water or pure water are compared, and effect of antiallergic sense is more notable；It is in good taste；And not spirituosity, the carcinogenic danger of alcohol is reduced, more
Safety；The side effects such as tooth discoloration are not produced；Also there is the effect of preventing decayed tooth and sterilization simultaneously, oral health can be preferably safeguarded.
The preferred embodiments of the present invention are the foregoing is only, the scope of the claims of the present invention, every utilization is not thereby limited
The equivalent structure transformation that present specification is made, or directly or indirectly with the technology neck for being attached to other Related products
Domain, is included within the scope of the present invention.
Claims (6)
1. a kind of preventing decayed tooth antiallergic pure water, it is characterised in that：Including following components in percentage by weight：The NMF of 8-15%, 1-
3% surfactant, the sweetener of 0.1-0.3%, the food antiseptics of 0.1-0.3%, the freshener of 0.08-0.2%,
The deionized water of the pigment of 0.0001-0.0002%, the ammonium hexafluorosilicate of 0.02-0.06% and surplus.
2. preventing decayed tooth antiallergic pure water according to claim 1, it is characterised in that：The fluorine of described preventing decayed tooth antiallergic pure water is dense
Degree is maintained within 0.7-1mg/L.
3. preventing decayed tooth antiallergic pure water according to claim 1, it is characterised in that：The concentration of described ammonium hexafluorosilicate is
0.02%。
4. preventing decayed tooth antiallergic pure water according to claim 1, it is characterised in that：Described preventing decayed tooth antiallergic pure water also includes
Percentage by weight is the cetylpyridinium chloride(CPC) of 0.03-0.05%.
5. preventing decayed tooth antiallergic pure water according to claim 1, it is characterised in that：The concentration of described cetylpyridinium chloride(CPC)
For 0.03%.
6. the preparation method of the preventing decayed tooth antiallergic pure water described in a kind of claim 1-5 any one, it is characterised in that：The method
At least comprise the steps：
Step 1：Prevented with the NMF of 8-15%, the surfactant of 1-3%, the sweetener of 0.1-0.3%, the edible of 0.1-0.3%
The deionized water of rotten agent, the freshener of 0.08-0.2% and surplus prepares pure water；
Step 2：Fluorine is added in pure water；
Step 3：Fluorine and pure water are well mixed, ammonium hexafluorosilicate, the chlorination of 0.03-0.05% of 0.02-0.06% is added
The pigment of hexadecane pyridine and 0.0001-0.0002%, continues to stir, and after all materials are well mixed, stops stirring；
Step 4：During the material-filling being well mixed to be entered the glass or plastic containers of lucifuge, finished product is finally obtained.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030133883A1 (en) * | 2001-06-14 | 2003-07-17 | Finnegan Mary Beth | Oral care compositions containing grapefruit seed extract |
| CN101999990A (en) * | 2010-11-18 | 2011-04-06 | 四川大学 | Anti-caries and antiallergic mouth wash |
| CN104254336A (en) * | 2012-02-10 | 2014-12-31 | 派瑞达克有限公司 | Multicomponent oral care composition |
-
2017
- 2017-01-15 CN CN201710026948.8A patent/CN106619157A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030133883A1 (en) * | 2001-06-14 | 2003-07-17 | Finnegan Mary Beth | Oral care compositions containing grapefruit seed extract |
| CN101999990A (en) * | 2010-11-18 | 2011-04-06 | 四川大学 | Anti-caries and antiallergic mouth wash |
| CN104254336A (en) * | 2012-02-10 | 2014-12-31 | 派瑞达克有限公司 | Multicomponent oral care composition |
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Application publication date: 20170510 |