CN106619129B - Processing device and method for oral instant tablets - Google Patents
Processing device and method for oral instant tablets Download PDFInfo
- Publication number
- CN106619129B CN106619129B CN201710046363.2A CN201710046363A CN106619129B CN 106619129 B CN106619129 B CN 106619129B CN 201710046363 A CN201710046363 A CN 201710046363A CN 106619129 B CN106619129 B CN 106619129B
- Authority
- CN
- China
- Prior art keywords
- hole
- female die
- die
- pressure
- round
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/09—Stirrers characterised by the mounting of the stirrers with respect to the receptacle
- B01F27/092—Stirrers characterised by the mounting of the stirrers with respect to the receptacle occupying substantially the whole interior space of the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/92—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with helices or screws
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
- B01F35/32—Driving arrangements
- B01F35/321—Disposition of the drive
- B01F35/3213—Disposition of the drive at the lower side of the axis, e.g. driving the stirrer from the bottom of a receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/20—Extrusion means, e.g. for producing pharmaceutical forms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a processing device and a processing method of an oral instant tablet, which comprises a stirring device, a powdery dry ice generating device, a pressing die and a pressure reducing device; pour powder into agitating unit bottom, cover powdered dry ice generating device, spout high-pressure carbon dioxide gas with nozzle drill way spout, carbon dioxide gas is cooled off by the annular cooling tank that is equipped with liquid nitrogen, form powdered dry ice, powdered dry ice sinks into cylindrical bottom of the pool because of gravity, stir powder and powdered dry ice evenly with agitating unit, pour the material that the stirring is good into the embossing mold utensil and suppress, the back is pressed to the tablet, put into pressure relief device with the tablet, cover the gland, adjust adjustable pressure valve and make powdered dry ice slowly release carbon dioxide gas, prevent that the tablet from making the tablet collapse because of the gaseous a large amount of quick releases of carbon dioxide, open discharge pipeline upper valve after carbon dioxide gas is slowly released to the dry ice, the tablet discharges through conical pressure chamber and discharge pipeline.
Description
Technical Field
The invention discloses a processing device and a processing method for an oral instant tablet, and belongs to the technical field of medicine processing.
Background
At present, the traditional processing method of oral tablets commonly used in society is to press and form medicinal powder through a mould, so that the tissues of the tablets are compact, the phenomena of incapability of quickly dissolving after entering a human body and quick absorption by the human body are caused, and the symptoms such as diarrhea, pain and the like can not be treated in time; when the effervescent tablet is contacted with water after entering a human body, organic acid and sodium bicarbonate are ionized under the action of the water and are subjected to decomposition reaction to generate a large amount of carbon dioxide, so that the human body is injured and unexpected conditions are caused.
Disclosure of Invention
The present invention is directed to solving the above-mentioned problems and an object of the present invention is to provide an apparatus and a method for processing an oral fast-dissolving tablet.
The invention aims to realize the purpose, and the processing device of the oral instant tablets is characterized in that: comprises a stirring device, a powdery dry ice generating device, a pressing die and a pressure reducing device;
the stirring device comprises a support frame, a cylindrical barrel, a stirring main shaft, a spiral blade and a motor, wherein the top of the cylindrical barrel is opened, one end of the stirring main shaft is arranged in the cylindrical barrel, the other end of the stirring main shaft extends out of the cylindrical barrel, the spiral blade is arranged on the stirring main shaft arranged in the cylindrical barrel, the motor is arranged at the bottom of the cylindrical barrel, and the motor main shaft on the motor is in transmission connection with the stirring main shaft; 2 support shafts are symmetrically arranged on the outer side of the cylindrical barrel, two sides of the upper end of the support frame are respectively provided with a U-shaped notch, and the 2 support shafts are respectively supported on the 2U-shaped notches of the support frame, so that the cylindrical barrel is supported on the support frame;
the powdery dry ice generating device comprises a stainless steel nozzle, a hose, a first valve, a feeding pipe gland, a feeding pipe, a cylindrical shell with an opening at the bottom and an annular liquid nitrogen storage tank which is arranged and fixed in the cylindrical shell, wherein one end of the stainless steel nozzle penetrates through the cylindrical shell and extends to the outer side of the annular liquid nitrogen storage tank in the cylindrical shell, the other end of the stainless steel nozzle is externally connected with high-pressure carbon dioxide gas through the hose, and the first valve is arranged on the hose; the feeding pipe penetrates through the cylindrical shell and is communicated with the annular liquid nitrogen storage tank, and the feeding pipe is covered on the feeding pipe by a pressing cover; handles are symmetrically arranged on two sides of the cylindrical shell, inner walls of two sides of the bottom of the cylindrical shell are provided with stepped inner holes, the cylindrical shell is supported on a cylindrical barrel of the stirring device through the stepped inner holes, and the cylindrical shell is communicated with the cylindrical barrel; a round hole is formed in the center of the stainless steel nozzle;
the pressing die comprises a die supporting frame, a male die and a female die, and the female die is arranged and fixed on the die supporting frame; the upper part of the female die is provided with a square groove, the middle part of the female die is provided with a plurality of round through holes, two sides of the lower part of the female die are provided with transverse through grooves, and female die stop blocks are inserted into the transverse through grooves on the two sides of the female die; the female die stop block is provided with a discharge hole with the aperture larger than that of the round through hole, the female die stop block is in clearance fit with the transverse through groove, the female die stop block can horizontally move along the transverse through groove, when the female die stop block horizontally moves along the transverse through groove, the discharge hole of the female die stop block is aligned with the round through hole of the female die, the discharge hole is communicated with the round through hole, when the position of the female die stop block without the discharge hole is aligned with the round through hole of the female die, and the round through hole is a blind hole with an opening at the upper end; the male die is provided with a sliding column matched with the round through hole on the female die, and the sliding column on the male die can be inserted into the round through hole on the female die and is excessively matched with the round through hole;
the pressure reducing device comprises a pressure bin support frame and an adjustable pressure valve, wherein the support frame is provided with a cylindrical pressure bin, and the adjustable pressure valve is connected with the cylindrical pressure bin through an exhaust pipeline; the upper end cover of the cylindrical pressure bin is provided with a spherical crown-shaped gland, the lower end of the cylindrical pressure bin is connected with a conical pressure bin in a run-through manner, the bottom of the conical pressure bin is provided with a discharge pipeline, and a second valve is arranged on the discharge pipeline.
Be equipped with first belt pulley on the motor main shaft on the motor, be equipped with the second belt pulley on the stirring main shaft, still be equipped with the belt, the belt twines on first belt pulley, the epaxial second belt pulley of stirring, and the motor passes through motor main shaft, first belt pulley, belt, the drive of second belt pulley stirring main shaft and rotates.
The aperture of the round hole on the stainless steel nozzle is less than or equal to 0.2 mm.
The male die is provided with a plurality of counter bores, and the plurality of sliding columns are in interference fit with the plurality of counter bores one by one.
And male die handles are symmetrically arranged on the outer sides of the male dies.
And a stop block handle is symmetrically arranged on the outer side of the female die stop block.
The spherical crown-shaped gland is characterized in that the ring extension of the spherical crown-shaped gland is provided with gland circular through holes which are regularly and symmetrically distributed, the upper end of the cylindrical pressure bin is provided with a fixing screw, and the gland circular through holes are sleeved on the fixing screw and are connected through nuts in a screwing manner.
A processing method of an oral instant tablet comprises the following steps: the method is characterized in that: comprises a stirring device, a powdery dry ice generating device, a pressing die and a pressure reducing device;
the stirring device comprises a supporting frame, a cylindrical barrel, a stirring main shaft, a helical blade and a motor, wherein the top of the cylindrical barrel is open, one end of the stirring main shaft is arranged in the cylindrical barrel, the other end of the stirring main shaft extends out of the cylindrical barrel, the helical blade is arranged on the stirring main shaft arranged in the cylindrical barrel, the motor is arranged at the bottom of the cylindrical barrel, a first belt pulley is arranged on the motor main shaft on the motor, a second belt pulley is arranged on the stirring main shaft, a belt is further arranged, the belt is wound on the first belt pulley and the second belt pulley on the stirring main shaft, and the motor drives the stirring main shaft to rotate through the motor main shaft, the first belt pulley, the belt and the second belt pulley; 2 support shafts are symmetrically arranged on the outer side of the cylindrical barrel, two sides of the upper end of the support frame are respectively provided with a U-shaped notch, and the 2 support shafts are respectively supported on the 2U-shaped notches of the support frame, so that the cylindrical barrel is supported on the support frame;
the powdery dry ice generating device comprises a stainless steel nozzle, a hose, a first valve, a feeding pipe gland, a feeding pipe, a cylindrical shell with an opening at the bottom and an annular liquid nitrogen storage tank which is arranged and fixed in the cylindrical shell, wherein one end of the stainless steel nozzle penetrates through the cylindrical shell and extends to the outer side of the annular liquid nitrogen storage tank in the cylindrical shell, the other end of the stainless steel nozzle is externally connected with high-pressure carbon dioxide gas through the hose, and the first valve is arranged on the hose; the feeding pipe penetrates through the cylindrical shell and is communicated with the annular liquid nitrogen storage tank, and the feeding pipe is covered on the feeding pipe by a pressing cover; handles are symmetrically arranged on two sides of the cylindrical shell, inner walls of two sides of the bottom of the cylindrical shell are provided with stepped inner holes, the cylindrical shell is supported on a cylindrical barrel of the stirring device through the stepped inner holes, and the cylindrical shell is communicated with the cylindrical barrel; a round hole with the aperture less than or equal to 0.2mm is formed in the center of the stainless steel nozzle;
the pressing die comprises a die supporting frame, a male die and a female die, and the female die is arranged and fixed on the die supporting frame; the upper part of the female die is provided with a square groove, the middle part of the female die is provided with a plurality of round through holes, two sides of the lower part of the female die are provided with transverse through grooves, and female die stop blocks are inserted into the transverse through grooves on the two sides of the female die; the female die stop block is provided with a discharge hole with the aperture larger than that of the round through hole, the female die stop block is in clearance fit with the transverse through groove, the female die stop block can horizontally move along the transverse through groove, when the female die stop block horizontally moves along the transverse through groove, the discharge hole of the female die stop block is aligned with the round through hole of the female die, the discharge hole is communicated with the round through hole, when the position of the female die stop block without the discharge hole is aligned with the round through hole of the female die, and the round through hole is a blind hole with an opening at the upper end; the male die is provided with a sliding column matched with the round through hole on the female die, and the sliding column on the male die can be inserted into the round through hole on the female die and is excessively matched with the round through hole; the male die is provided with a plurality of counter bores, the plurality of sliding columns and the plurality of counter bores are in interference fit one by one respectively, male die handles are symmetrically arranged on the outer side of the male die, and stop block handles are symmetrically arranged on the outer side of the female die stop block;
the pressure reducing device comprises a pressure bin support frame and an adjustable pressure valve, wherein the support frame is provided with a cylindrical pressure bin, and the adjustable pressure valve is connected with the cylindrical pressure bin through an exhaust pipeline; the upper end of the cylindrical pressure bin is covered with a spherical crown-shaped gland, the lower end of the cylindrical pressure bin is connected with a conical pressure bin in a run-through manner, the bottom of the conical pressure bin is provided with a discharge pipeline, and the discharge pipeline is provided with a second valve; the spherical crown-shaped gland is characterized in that gland circular through holes are regularly and symmetrically distributed on the circular ring extension of the spherical crown-shaped gland, a fixing screw is arranged at the upper end of the cylindrical pressure bin, and the gland circular through holes are sleeved on the fixing screw and are connected through nuts in a screwing manner;
when in use, the medicinal powder is added into a cylindrical barrel of the stirring device; then, unscrewing a feed pipe gland on the feed pipe, adding liquid nitrogen into a circular liquid nitrogen storage tank in the powdery dry ice generating device through the feed pipe, and screwing the feed pipe gland to be fixed on the feed pipe after the liquid nitrogen is added; then, opening a first valve, spraying high-pressure carbon dioxide gas with the air pressure higher than a standard atmospheric pressure to the outer side of an annular liquid nitrogen storage tank through circular holes in a hose and a stainless steel nozzle, cooling the high-pressure carbon dioxide gas by the annular liquid nitrogen storage tank filled with liquid nitrogen to form powdered dry ice, sinking the powdered dry ice into the bottom of a cylindrical barrel through a lower opening of the cylindrical shell due to gravity, starting a motor on a stirring device to enable a motor main shaft to drive a first belt pulley to rotate, driving a second belt pulley to rotate through a belt in the rotation of the first belt pulley, driving a stirring main shaft to rotate through the rotation of the second belt pulley, driving a helical blade to rotate through the rotation of the stirring main shaft, and enabling the powder and the powdered dry ice to be uniformly stirred in the cylindrical barrel through the rotation of the helical blade; when the liquid nitrogen in the annular liquid nitrogen storage tank is lack, unscrewing a feed pipe gland on the feed pipe, adding the liquid nitrogen through the feed pipe, and screwing the feed pipe gland on the feed pipe after the liquid nitrogen is added;
then grasping a symmetrical stop block handle on the outer side of a female die stop block, moving the female die stop block to align the position without a discharge hole on the female die stop block with the position of a round through hole of a female die, pouring the uniformly stirred medicine powder and powdered dry ice into a square groove at the upper end of the female die, grasping a symmetrical male die handle on the outer side of a male die, pressing down the male die, enabling a slide column on the male die to be in excessive fit with the round through hole of the female die, and pressing the uniformly stirred medicine powder and powdered dry ice into tablets; then grasping a handle of a symmetrical stop block outside the female die stop block to move the female die stop block, aligning the position of a discharge hole on the female die stop block with the position of a round through hole in the female die, pressing down the male die, and using a sliding column to enable the tablets to fall off;
put into the tablet that will drop and reduce the pressure of pressure relief device, open pressure relief device's spherical crown gland, put into cask shape pressure reservoir with the tablet that powder and the even stirring thing of powdered dry ice pressed, then cover spherical crown gland, adjust adjustable pressure valve and make the powdered dry ice in the cask shape pressure reservoir slowly release carbon dioxide, prevent that the tablet from making the tablet collapse because of carbon dioxide gas quick release, slowly release carbon dioxide gas at powdered dry ice after, open the second valve on the ejection of compact pipeline, the tablet is discharged through conical pressure reservoir and ejection of compact pipeline, be formed with the oral instant tablet in irregular hole.
The invention has reasonable structure and advanced and scientific method, and the powder is poured into the bottom of a cylindrical barrel of a stirring device by the invention, the stirring device comprises a stainless steel cylindrical barrel, a stainless steel spiral stirrer, a motor, a belt pulley and a belt, the powdery dry ice generating device is covered, the powdery dry ice generating device comprises a circular liquid nitrogen storage tank, a nozzle, a hose and a first valve for liquid nitrogen, high-pressure carbon dioxide gas (the air pressure is more than one standard atmospheric pressure) is sprayed out by a circular hole (the aperture of the circular hole is less than or equal to 0.2 mm) on the nozzle, the carbon dioxide gas is cooled by the circular liquid nitrogen storage tank filled with the liquid nitrogen to form the powdery dry ice, the powdery dry ice sinks into the cylindrical barrel bottom of the stirring device due to gravity, the powder and the powdery dry ice are uniformly stirred by the stirring device, the powdery dry ice generating device is removed, and the uniformly stirred substances (the powder and the powdery dry ice) are poured into a pressing die for pressing, the pressing die comprises a support frame, a female die, a male die and a female die stop block, wherein a square groove is arranged at the upper end of the female die, a vertically through regular round through hole is arranged in the middle of the female die, transverse through grooves are arranged on two sides of the lower portion of the female die, the female die stop block and the transverse through grooves are in clearance fit, the female die stop block can move back and forth, a stop block handle is arranged in the middle of the female die, an vertically through regular discharge hole larger than the central round through hole of the female die is arranged in the middle of the female die, a regular counter bore and a slide column are in interference fit, the vertically through regular round through hole in the middle of the slide column on the male die and the female die is in excessive fit, the stop block handle is grasped to move the female die stop block during tablet pressing, the position without the discharge hole on the female die stop block is aligned to the position with the vertically through regular round hole in the middle of the female die, the male die is pressed, the vertically through regular round hole in excessive fit in the upper portion of the slide column on the male die, and the powder and the uniformly stirred dry ice are pressed into tablets, then grasping the stopper handle to move the female die stopper, aligning the position of a hole on the female die stopper with the position of a regular circular through hole which is communicated up and down in the middle of the female die, pressing down an upper sliding column of the male die to make the tablets fall off, putting the tablets into a barrel-shaped pressure bin, wherein the barrel-shaped pressure bin comprises a gland, an exhaust pipeline, an adjustable pressure valve, a conical pressure bin connected with the lower end of the barrel-shaped pressure bin, a second valve on a discharge pipeline, a discharge pipeline and circular through holes which are regularly and symmetrically distributed on the extension of a gland ring, the gland ring is matched with the gland circular through holes which are regularly and symmetrically distributed on the extension of the gland ring and fixed by nuts, the adjustable pressure valve is adjusted to make powdery dry ice slowly release carbon dioxide gas, so that the tablets are prevented from being crashed due to the rapid release of a large amount of carbon dioxide gas, and the second valve on the discharge pipeline is opened after the dry ice slowly releases the carbon dioxide gas, the tablets are discharged through the conical pressure bin and the discharge pipeline.
In brief, the invention comprises a stirring device, a powdery dry ice generating device, a pressing die and a pressure reducing device; pour powder into agitating unit bottom, cover powdered dry ice generating device, spout high-pressure carbon dioxide gas with nozzle drill way spout, carbon dioxide gas is cooled off by the annular cooling tank that is equipped with liquid nitrogen, form powdered dry ice, powdered dry ice sinks into cylindrical bottom of the pool because of gravity, stir powder and powdered dry ice evenly with agitating unit, pour the material that the stirring is good into the embossing mold utensil and suppress, the back is pressed to the tablet, put into pressure relief device with the tablet, cover the gland, adjust adjustable pressure valve and make powdered dry ice slowly release carbon dioxide gas, prevent that the tablet from making the tablet collapse because of the gaseous a large amount of quick releases of carbon dioxide, open discharge pipeline upper valve after carbon dioxide gas is slowly released to the dry ice, the tablet discharges through conical pressure chamber and discharge pipeline.
Drawings
FIG. 1 is a front view of the working structure of a stirring device and a powdery dry ice generating device according to the present invention;
FIG. 2 is a left side view of the operation structure of the stirring device and the powdery dry ice generating device of the present invention;
fig. 3 is a bottom view of the powdered dry ice generating device of the present invention;
FIG. 4 is a front view of the working structure of the pressing mold in the present invention;
FIG. 5 is a top view of a female mold in the pressing mold according to the present invention;
FIG. 6 is a top view of a male mold in the pressing mold of the present invention;
FIG. 7 is a schematic view of a female mold block in the pressing mold of the present invention;
FIG. 8 is a front view of the working structure of the barrel-shaped pressure chamber of the present invention;
FIG. 9 is a top view of the upper gland of the barrel-shaped pressure silo of the present invention;
FIG. 10 is an enlarged schematic view of a feed port for liquid nitrogen in the powdered dry ice generating device according to the present invention;
FIG. 11 is an enlarged schematic view of a finished oral fast dissolving tablet of the present invention;
in the figure: 1 stirring main shaft, 2 helical blades, 3 support frames, 4 support shafts, 5 handles, 6 barrel-shaped shells, 7 stainless steel nozzles, 8 hoses, 9 first valves, 10 feed pipe gland covers, 11 feed pipes, 12 liquid nitrogen, 13 stepped inner holes, 14 medicinal powder, 15 motors, 16 motor main shafts, 17 first belt discs, 18 belts, 19 second belt discs, 20U-shaped notches, 21 annular liquid nitrogen storage tanks, 22 mold support frames, 23 circular through holes, 24 square grooves, 25 male molds, 26 counter bores, 27 sliding columns, 28 female molds, 29 female mold stoppers, 30 pressing molds, 31 male mold handles, 32 stopper handles, 33 discharge holes, 34 pressure bin support frames, 35 pressure bins, 36 fixed screws, 37 crown-shaped spherical gland covers, 38 circular ring extensions, 39 exhaust pipelines, 40 adjustable pressure valves, 41 conical pressure bins, 42 second valves, 43 discharge pipelines, 44 round through holes of a gland, 45 internal threads of the gland of a feed pipe, 46 external threads of the feed pipe, 47 irregular holes formed after oral administration of instant tablets and 48 powdered dry ice are volatilized, 49 round holes, 50 pressure reducing devices, 51 transverse through grooves, 52 stirring devices, 53 cylindrical barrels and 54 powdered dry ice generating devices.
Detailed Description
The technical scheme of the invention is further explained in detail in the following with the accompanying drawings of the specification.
As shown in figures 1 to 11, a method for processing oral instant tablets comprises the steps of pouring medicinal powder 14 into the bottom of a cylindrical barrel 53 of a stirring device, wherein the stirring device 52 comprises a stirring main shaft 1, a spiral blade 2 on the stirring device, a support frame 3, 2 support shafts 4 on the outer side of the stirring device, a motor 15, a motor main shaft 16, a first belt pulley 17 matched with the motor main shaft, a belt 18, a second belt pulley 19 matched with the main shaft on the stirring mechanism, a U-shaped notch 20 formed in the upper end of the support frame 3 and a cylindrical barrel 53, putting the 2 support shafts 4 on the outer side of the stirring device 52 into the U-shaped notch 20, covering a powdery dry ice generating device 54, and the powdery dry ice generating device 54 comprises an annular liquid nitrogen storage tank 21, a handle 5, a cylindrical shell 6, a stainless steel nozzle 7, a hose 8, a first valve 9, a feeding pipe gland 10, a feeding pipe 11, a liquid nitrogen 12, nitrogen, The powder dry ice generating device 53 is provided with an inner hole 13 with a step, when in use, a first valve 9 is opened, high-pressure carbon dioxide gas (the gas pressure is more than one standard atmospheric pressure) is sprayed out by a round hole 49 which is less than 0.2mm on the center of a stainless steel nozzle, the high-pressure carbon dioxide gas with the gas pressure more than one standard atmospheric pressure is sprayed out to the outer side of a circular liquid nitrogen storage tank 21 through a hose 8 and the round hole 49 on the stainless steel nozzle 7, the carbon dioxide gas is cooled by the circular liquid nitrogen storage tank 21 filled with liquid nitrogen 12 to form powder dry ice, the powder dry ice sinks into the bottom of a cylindrical barrel 53 due to gravity, a motor 15 on a stirring device 52 is started to enable a motor spindle 16 to drive a first belt pulley 17 to rotate, the first belt pulley 17 drives a second belt pulley 19 to rotate through a belt 18, the second belt 19 drives a stirring spindle 1 to rotate, and the stirring spindle 1 drives a helical blade 2 to rotate, uniformly stirring the medicine powder 14 and the powdered dry ice, closing a first valve 9, moving away the powdered dry ice generating device 54 (if liquid nitrogen 12 in the powdered dry ice generating device 54 is lack, rotating an inner thread 45 of a gland of a feeding pipe to separate a pipe gland 10 from an outer thread 46 of the feeding pipe, adding the liquid nitrogen 12 through the feeding pipe 11, rotating the inner thread 45 of the gland of the feeding pipe to fix the gland of the feeding pipe 10 on the feeding pipe 11), pouring uniformly stirred substances (the medicine powder and the powdered dry ice) into a pressing mould 30 for pressing, wherein the pressing mould 30 comprises a mould supporting frame 22, a male mould 25, a female mould 28, a male mould handle 31 and a counter bore 26 are symmetrically arranged on the outer side of the male mould 25, and a slide column 27 is arranged in the counter bore 26; the upper end of the female die 28 is provided with a square groove 24, the middle of the female die is provided with a regular round through hole 23, and the lower part of the female die is provided with a female die stop block 29; a stopper handle 32 and a middle regular discharge hole 33 are symmetrically arranged on the outer side of the stopper, and the regular discharge hole 33 is larger than the regular circular through hole 23; the shape of the punch 25 is smaller than that of a square groove 24 at the upper end of the die 28 to form transition fit, the diameter of a slide column 27 arranged in a regular counter bore 26 is smaller than that of a regular round through hole 23 in the middle of the groove 24 to form transition fit, the round through hole 23 is smaller than that of a regular discharge hole 33 to enable the slide column 27 arranged in the regular counter bore 26 to form clearance fit with the discharge hole 33, transverse through grooves 51 are arranged at two sides of the lower part of the die 28, die stoppers 29 are inserted into the transverse through grooves 51 at the two sides, the die stoppers 29 are in clearance fit with the transverse through grooves 51, the die stoppers 29 can move back and forth, a symmetrical stopper handle 32 at the outer side of the die stopper 29 is grasped during pressing, the positions without the discharge hole 33 on the die stopper 29 are aligned with the positions of the round through hole 23 in the middle of the die 28 by moving the die stopper 29, uniformly stirred substances (powder and powdery dry ice) are poured into the square groove 24 at the upper end of the die 28, the symmetrical punch handle 31 at the outer side of the punch 25 is grasped, pressing down the male die 25, enabling a sliding column 27 on the male die 25 to be in over-fit with a regular round through hole 23 in the middle of the female die 28, pressing the medicine powder 14 and the powdery dry ice uniformly stirred substance into tablets, grasping a symmetrical stop block handle 32 on the outer side of a female die stop block 29 to move the female die stop block 29, aligning the position of a regular discharge hole 33 in the middle of the female die stop block 29 with the position of the regular round through hole 23 in the middle of the female die 24, pressing down the male die 25, enabling the tablets to fall off by using the sliding column 27, putting the fallen tablets into a pressure reduction device 50 for pressure reduction, the pressure reducing device 50 comprises a pressure bin support frame 34, a barrel-shaped pressure bin 35, a fixing screw 36 at the upper end of the barrel-shaped pressure bin, a spherical crown-shaped gland 37, a spherical crown-shaped gland ring extension 38, an exhaust pipeline 39, an adjustable pressure valve 40, a conical pressure bin 41 connected with the lower end of the barrel-shaped pressure bin, a second valve 42 on a discharge pipeline, a discharge pipeline 43 and gland ring through holes 44 which are regularly and symmetrically distributed on the gland ring extension 38; putting the dropped tablets into a pressure reducing device 50 for pressure reduction, opening a spherical crown-shaped gland 37 of the pressure reducing device 50, putting the tablets formed by uniformly stirring medicinal powder and powdered dry ice into a cylindrical pressure bin 35, then covering the spherical crown-shaped gland 37, covering the gland 37 to match circular through holes 44 which are regularly and symmetrically distributed on a gland ring extension 37 with a fixing screw 36 at the upper end of the cylindrical pressure bin 35 and fixing the circular through holes with nuts, adjusting an adjustable pressure valve 40 to enable the powdered dry ice to slowly release carbon dioxide gas, so that the tablets can be prevented from being crashed due to the quick release of the carbon dioxide gas, opening a second valve 42 on a discharge pipeline 43 after the carbon dioxide gas is slowly released, and discharging the tablets through a conical pressure bin 41 and the discharge pipeline 43 to form an oral instant tablet 47 with irregular holes 48.
Claims (9)
1. The utility model provides a processingequipment of instant tablet of oral administration, characterized by: comprises a stirring device (52), a powdery dry ice generating device (54), a pressing die (30) and a pressure reducing device (50);
the stirring device (52) comprises a support frame (3), a cylindrical barrel (53), a stirring main shaft (1), a spiral blade (2) and a motor (15), wherein the top of the cylindrical barrel (53) is open, one end of the stirring main shaft (1) is arranged in the cylindrical barrel (53), the other end of the stirring main shaft extends out of the cylindrical barrel (53), the spiral blade (2) is arranged on the stirring main shaft (1) arranged in the cylindrical barrel (53), the motor (15) is arranged at the bottom of the cylindrical barrel (53), and a motor main shaft (16) on the motor (15) is in transmission connection with the stirring main shaft (1); 2 support shafts (4) are symmetrically arranged on the outer side of the cylindrical barrel (53), two sides of the upper end of the support frame (3) are respectively provided with a U-shaped notch (20), and the 2 support shafts (4) are respectively supported on the 2U-shaped notches (20) of the support frame (3), so that the cylindrical barrel (53) is supported on the support frame (3);
the powdery dry ice generating device (54) comprises a stainless steel nozzle (7), a hose (8), a first valve (9), a feeding pipe gland (10), a feeding pipe (11), a barrel-shaped shell (6) with an opening at the bottom and a circular liquid nitrogen storage tank (21) fixed in the barrel-shaped shell (6), wherein one end of the stainless steel nozzle (7) penetrates through the barrel-shaped shell (6) to extend to the outer side of the circular liquid nitrogen storage tank (21), the other end of the stainless steel nozzle is externally connected with high-pressure carbon dioxide gas through the hose (8), and the first valve (9) is arranged on the hose (8); the feeding pipe (11) penetrates through the cylindrical shell (6) and is communicated with the annular liquid nitrogen storage tank (21), and a feeding pipe gland (10) covers the feeding pipe (11); inner walls of two sides of the bottom of the barrel-shaped shell (6) are provided with stepped inner holes (13), the barrel-shaped shell (6) is supported on a cylindrical barrel (53) of the stirring device (52) through the stepped inner holes (13), and the barrel-shaped shell (6) is communicated with the cylindrical barrel (53); a round hole (49) is formed in the center of the stainless steel nozzle (7);
the pressing mould (30) comprises a mould supporting frame (22), a male mould (25) and a female mould (28), and the female mould (28) is fixedly arranged on the mould supporting frame (22); a square groove (24) is formed in the upper portion of the female die (28), a plurality of round through holes (23) are formed in the middle of the female die, transverse through grooves (51) are formed in two sides of the lower portion of the female die, and female die stop blocks (29) are inserted into the transverse through grooves (51) in the two sides of the female die; the female die stopper (29) is provided with a discharge hole (33) with the aperture larger than that of the round through hole (23), the female die stopper (29) is in clearance fit with the transverse through groove (51), the female die stopper (29) can horizontally move along the transverse through groove (51), when the female die stopper (29) horizontally moves along the transverse through groove (51), when the discharge hole (33) of the female die stopper (29) is aligned with the round through hole (23) of the female die (28), the discharge hole (33) is communicated with the round through hole (23), when the female die stopper (29) is not provided with the discharge hole (33), the round through hole (23) of the female die (28) is aligned with the round through hole (23), and the round through hole (23) is a blind hole with an opening at the upper end; the male die (25) is provided with a sliding column (27) matched with the round through hole (23) on the female die (28), and the sliding column (27) on the male die (25) can be inserted into the round through hole (23) on the female die (28) and is excessively matched with the round through hole (23);
the pressure reducing device (50) comprises a pressure bin support frame (34) and an adjustable pressure valve (40), wherein a barrel-shaped pressure bin (35) is arranged on the pressure bin support frame (34), and the adjustable pressure valve (40) is connected with the barrel-shaped pressure bin (35) through an exhaust pipeline (39); the upper end cover of cask shape pressure chamber (35) has spherical crown shape gland (37), and the lower extreme through connection has conical pressure chamber (41), and conical pressure chamber (41) bottom is equipped with ejection of compact pipeline (43), is equipped with second valve (42) on ejection of compact pipeline (43).
2. The apparatus for processing an oral fast-dissolving tablet as claimed in claim 1, wherein: be equipped with first belt pulley (17) on motor spindle (16) on motor (15), be equipped with second belt pulley dish (19) on stirring main shaft (1), still be equipped with belt (18), on belt (18) twine on second belt pulley dish (19) on first belt pulley dish (17), stirring main shaft (1), motor (15) are through motor spindle (16), first belt pulley dish (17), belt (18), second belt pulley dish (19) drive stirring main shaft (1) and are rotated.
3. The apparatus of claim 1, wherein: the aperture of the round hole (49) on the stainless steel nozzle (7) is less than or equal to 0.2 mm.
4. The apparatus of claim 1, wherein: the male die (25) is provided with a plurality of counter bores (26), and the plurality of sliding columns (27) are in interference fit with the plurality of counter bores (26) one by one respectively.
5. The apparatus of claim 1, wherein: and male die handles (31) are symmetrically arranged on the outer sides of the male dies (25).
6. The apparatus of claim 1, wherein: and stopper handles (32) are symmetrically arranged on the outer side of the female die stopper (29).
7. The apparatus for processing an oral fast dissolving tablet as set forth in claim 1, wherein: the spherical crown-shaped gland (37) is characterized in that gland circular through holes (44) are regularly and symmetrically distributed on a circular ring extension (38), a fixing screw rod (36) is arranged at the upper end of the cylindrical pressure bin (35), and the gland circular through holes (44) are sleeved on the fixing screw rod (36) and are screwed and connected through nuts.
8. The apparatus for processing an oral fast dissolving tablet as set forth in claim 1, wherein: handles (5) are symmetrically arranged on two sides of the cylindrical shell (6).
9. A processing method of an oral instant tablet comprises the following steps: the method is characterized in that: comprises a stirring device (52), a powdery dry ice generating device (54), a pressing die (30) and a pressure reducing device (50);
agitating unit (52) are including support frame (3), cylindrical bucket (53), stirring main shaft (1), helical blade (2), motor (15), the open-top of cylindrical bucket (53), cylindrical bucket (53) is arranged in to the one end of stirring main shaft (1), cylindrical bucket (53) is stretched out to the other end, helical blade (2) set up on stirring main shaft (1) of arranging cylindrical bucket (53) in, motor (15) set up in cylindrical bucket (53) bottom, and be equipped with first belt pulley (17) on motor (15) motor main shaft (16), be equipped with second belt pulley dish (19) on stirring main shaft (1), still be equipped with belt (18), belt (18) twine on first belt pulley (17), on second belt pulley dish (19) on stirring main shaft (1), motor (15) are through motor main shaft (16), first belt pulley dish (17), The belt (18) and the second belt disc (19) drive the stirring main shaft (1) to rotate; 2 support shafts (4) are symmetrically arranged on the outer side of the cylindrical barrel (53), two sides of the upper end of the support frame (3) are respectively provided with a U-shaped notch (20), and the 2 support shafts (4) are respectively supported on the 2U-shaped notches (20) of the support frame (3), so that the cylindrical barrel (53) is supported on the support frame (3);
the powdery dry ice generating device (54) comprises a stainless steel nozzle (7), a hose (8), a first valve (9), a feeding pipe gland (10), a feeding pipe (11), a cylindrical shell (6) with an opening at the bottom and a circular liquid nitrogen storage tank (21) fixed in the cylindrical shell (6), wherein one end of the stainless steel nozzle (7) penetrates through the cylindrical shell (6) to extend to the outer side of the circular liquid nitrogen storage tank (21), the other end of the stainless steel nozzle is externally connected with high-pressure carbon dioxide gas through the hose (8), and the first valve (9) is arranged on the hose (8); the feeding pipe (11) penetrates through the cylindrical shell (6) and is communicated with the annular liquid nitrogen storage tank (21), and a feeding pipe gland (10) covers the feeding pipe (11); handles (5) are symmetrically arranged on two sides of the barrel-shaped shell (6), inner walls of two sides of the bottom are provided with stepped inner holes (13), the barrel-shaped shell (6) is supported on a cylindrical barrel (53) of the stirring device (52) through the stepped inner holes (13), and the barrel-shaped shell (6) is communicated with the cylindrical barrel (53); a round hole (49) with the aperture smaller than or equal to 0.2mm is arranged at the center of the stainless steel nozzle (7);
the pressing mould (30) comprises a mould supporting frame (22), a male mould (25) and a female mould (28), and the female mould (28) is fixedly arranged on the mould supporting frame (22); a square groove (24) is formed in the upper portion of the female die (28), a plurality of round through holes (23) are formed in the middle of the female die, transverse through grooves (51) are formed in two sides of the lower portion of the female die, and female die stop blocks (29) are inserted into the transverse through grooves (51) in the two sides of the female die; the die stopper (29) is provided with a discharge hole (33) with the aperture larger than that of the round through hole (23), the die stopper (29) is in clearance fit with the transverse through groove (51), the die stopper (29) can horizontally move along the transverse through groove (51), when the die stopper (29) horizontally moves along the transverse through groove (51), when the discharge hole (33) of the die stopper (29) is aligned with the round through hole (23) of the die (28), the discharge hole (33) is communicated with the round through hole (23), when the die stopper (29) is not provided with the discharge hole (33), the position of the die stopper (29) is aligned with the round through hole (23) of the die (28), and the round through hole (23) is a blind hole with an opening at the upper end; the male die (25) is provided with a sliding column (27) matched with the round through hole (23) on the female die (28), and the sliding column (27) on the male die (25) can be inserted into the round through hole (23) on the female die (28) and is excessively matched with the round through hole (23); a plurality of counter bores (26) are formed in the male die (25), a plurality of sliding columns (27) are in interference fit with the counter bores (26) one by one, male die handles (31) are symmetrically arranged on the outer side of the male die (25), and stop block handles (32) are symmetrically arranged on the outer side of the female die stop block (29);
the pressure reducing device (50) comprises a pressure bin support frame (34) and an adjustable pressure valve (40), wherein a barrel-shaped pressure bin (35) is arranged on the pressure bin support frame (34), and the adjustable pressure valve (40) is connected with the barrel-shaped pressure bin (35) through an exhaust pipeline (39); the upper end of the cylindrical pressure bin (35) is covered with a spherical crown-shaped gland (37), the lower end of the cylindrical pressure bin is connected with a conical pressure bin (41) in a penetrating way, the bottom of the conical pressure bin (41) is provided with a discharge pipeline (43), and the discharge pipeline (43) is provided with a second valve (42); a circular ring extension (38) of the spherical crown-shaped gland (37) is provided with gland circular through holes (44) which are regularly and symmetrically distributed, the upper end of the cylindrical pressure bin (35) is provided with a fixing screw rod (36), and the gland circular through holes (44) are sleeved on the fixing screw rod (36) and are connected by screwing nuts;
when in use, the medicinal powder is added into a cylindrical barrel (53) of the stirring device (52); then, unscrewing a feed pipe gland (10) on the feed pipe (11), adding liquid nitrogen into a circular liquid nitrogen storage tank (21) in the powdery dry ice generating device (54) through the feed pipe (11), and screwing and fixing the feed pipe gland (10) on the feed pipe (11) after the liquid nitrogen is added; then, a first valve (9) is opened, high-pressure carbon dioxide gas with the air pressure larger than a standard atmospheric pressure is sprayed to the outer side of a circular liquid nitrogen storage tank (21) through a hose (8) and a circular hole (49) on a stainless steel nozzle (7), the high-pressure carbon dioxide gas is cooled by the circular liquid nitrogen storage tank (21) filled with liquid nitrogen to form powdery dry ice, the powdery dry ice sinks into the bottom of a cylindrical barrel (53) through a lower opening of the cylindrical shell (6) due to gravity, a motor (15) on a stirring device (52) is started to enable a motor spindle (16) to drive a first belt pulley (17) to rotate, the rotation of the first belt pulley (17) drives a second belt pulley (19) to rotate through a belt (18), the rotation of the second belt pulley (19) drives a stirring spindle (1) to rotate, and the rotation of the stirring spindle (1) drives a spiral blade (2) to rotate, the rotation of the helical blade (2) enables the medicine powder and the powdery dry ice to be uniformly stirred in the cylindrical barrel (53); when the liquid nitrogen in the annular liquid nitrogen storage tank (21) is lack, unscrewing a feed pipe gland (10) on the feed pipe (11), adding the liquid nitrogen through the feed pipe (11), and screwing the feed pipe gland (10) and fixing the feed pipe gland on the feed pipe (11) after the liquid nitrogen is added;
then grasping a symmetrical stop block handle (32) on the outer side of a female die stop block (29), moving the female die stop block (29) to align the position without a discharge hole (33) on the female die stop block (29) to the position of a round through hole (23) of a female die (28), pouring uniformly stirred medicine powder and powdered dry ice into a square groove (24) at the upper end of the female die (28), grasping a symmetrical male die handle (31) on the outer side of a male die (25), pressing down the male die (25), enabling a sliding column (27) on the male die (25) to be in excessive fit with the round through hole (23) of the female die (28), and pressing the medicine powder and the powdered dry ice uniformly stirred substance into tablets; then, a symmetrical stopper handle (32) outside the female die stopper (29) is grasped to move the female die stopper (29), the position of a discharge hole (33) on the female die stopper (29) is aligned with the position of a round through hole (23) in the female die (28), the male die (25) is pressed down, and a sliding column (27) is used for enabling the tablets to fall off;
put into pressure relief device (50) decompression with the tablet that drops, open the spherical crown gland (37) of pressure relief device (50), put into cask shape pressure reservoir (35) with the tablet that powder and the even stirring thing of powdered dry ice pressed, then cover spherical crown gland (37), adjust adjustable pressure valve (40) and make the powdered dry ice in cask shape pressure reservoir (35) slowly release carbon dioxide gas, prevent that the tablet from making the tablet collapse because of carbon dioxide gas releases fast, after powdered dry ice slowly releases carbon dioxide gas, open second valve (42) on ejection of compact pipeline (43), the tablet is discharged through conical pressure reservoir (41) and ejection of compact pipeline (43), be formed with the oral instant tablet in irregular hole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710046363.2A CN106619129B (en) | 2017-01-22 | 2017-01-22 | Processing device and method for oral instant tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710046363.2A CN106619129B (en) | 2017-01-22 | 2017-01-22 | Processing device and method for oral instant tablets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106619129A CN106619129A (en) | 2017-05-10 |
| CN106619129B true CN106619129B (en) | 2022-08-23 |
Family
ID=58841876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710046363.2A Active CN106619129B (en) | 2017-01-22 | 2017-01-22 | Processing device and method for oral instant tablets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106619129B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107456391A (en) * | 2017-09-18 | 2017-12-12 | 盐城方正医药科技有限公司 | A kind of Simvastatin high-volume automatic production device |
| NL2032691B1 (en) * | 2022-08-05 | 2024-02-09 | Taiwan Mercury Medical Corp | Compound gel manufacturing equipment |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1203308A (en) * | 1967-10-02 | 1970-08-26 | Miles Lab | Improvements in or relating to tableting lubricants and tableting processes |
| US4265847A (en) * | 1978-03-30 | 1981-05-05 | Kirby Pharmaceuticals Ltd | Tabletting process |
| CN101601636A (en) * | 2009-05-12 | 2009-12-16 | 扬州大学 | A kind of hydrotherapy preparation and preparation method thereof |
| CN102058480A (en) * | 2009-11-17 | 2011-05-18 | 天津天士力制药股份有限公司 | Oral effervescent tablet and preparation method thereof |
| CN103140218A (en) * | 2010-09-22 | 2013-06-05 | 麦克内尔-Ppc股份有限公司 | Multi-layered orally disintegrating tablet and the manufacture thereof |
| CN103191023A (en) * | 2013-03-22 | 2013-07-10 | 海南卫康制药(潜山)有限公司 | Low-temperature pressing method of rapidly disintegrating tablet |
| CN105287421A (en) * | 2015-12-01 | 2016-02-03 | 上海中医药大学 | Paeonol gastric floating tablet and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10022329B2 (en) * | 2015-03-18 | 2018-07-17 | Frederick Marius | Carbohydrate tablet and method of fabrication |
-
2017
- 2017-01-22 CN CN201710046363.2A patent/CN106619129B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1203308A (en) * | 1967-10-02 | 1970-08-26 | Miles Lab | Improvements in or relating to tableting lubricants and tableting processes |
| US4265847A (en) * | 1978-03-30 | 1981-05-05 | Kirby Pharmaceuticals Ltd | Tabletting process |
| CN101601636A (en) * | 2009-05-12 | 2009-12-16 | 扬州大学 | A kind of hydrotherapy preparation and preparation method thereof |
| CN102058480A (en) * | 2009-11-17 | 2011-05-18 | 天津天士力制药股份有限公司 | Oral effervescent tablet and preparation method thereof |
| CN103140218A (en) * | 2010-09-22 | 2013-06-05 | 麦克内尔-Ppc股份有限公司 | Multi-layered orally disintegrating tablet and the manufacture thereof |
| CN103191023A (en) * | 2013-03-22 | 2013-07-10 | 海南卫康制药(潜山)有限公司 | Low-temperature pressing method of rapidly disintegrating tablet |
| CN105287421A (en) * | 2015-12-01 | 2016-02-03 | 上海中医药大学 | Paeonol gastric floating tablet and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 压力容器在食品加工中的应用（一）;郑津洋;《化工装备技术》;19960805;第17卷(第4期);37-41 * |
| 复方酪萨维口腔速崩片的制备及质量控制;姚敏娜等;《中国医院药学杂志》;20130615;第33卷(第11期);849-852 * |
| 维C佳钙泡腾片的处方工艺研究;黄晓燕等;《中国医药导报》;20080525;第5卷(第15期);38-40 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106619129A (en) | 2017-05-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106619129B (en) | Processing device and method for oral instant tablets | |
| EP3238546B1 (en) | Apparatus for making freshly squeezed orange juice | |
| CN207254392U (en) | A kind of medical saw-blade type is pulverized and mixed device | |
| CN209905121U (en) | Particle packaging machine convenient for adjusting filling amount | |
| CN109483931A (en) | A kind of beverage can recycling baling press | |
| CN111331911A (en) | Tablet processing device and method | |
| CN109481306A (en) | A kind of medicinal tea water-bindered pill molding machine | |
| AU2019202907B2 (en) | A disposable beverage cup | |
| CN217377404U (en) | Sewage disinfection device convenient for adding medicament | |
| CN103536183B (en) | Juice extracting machine | |
| CN216260960U (en) | Medicine grinder for rehabilitation therapy | |
| CN112520141B (en) | Packing apparatus is handled to timber processing factory abandonment timber | |
| CN215013118U (en) | Meatball size adjusting mechanism for meatball forming machine | |
| CN112061602B (en) | Vaccine bottle cold storage transportation and storage device | |
| CN206062855U (en) | A kind of fruit press cup | |
| CN212353020U (en) | Processing production equipment of shaddock tea | |
| CN212468295U (en) | Essence raw materials grinding device | |
| CN207565031U (en) | A kind of drug tablet press machine | |
| CN203483510U (en) | Medical equipment with detachable alcohol box | |
| CN112455953A (en) | Dampproofing dona tub convenient to remove | |
| CN113941412B (en) | Extraction and preparation system of ginger active ingredients | |
| CN112373961A (en) | Moisture-proof storage container for flaky tablets | |
| CN218898216U (en) | Green tangerine peel walnut processing peeling device | |
| CN211074810U (en) | Extraction element for pharmacy | |
| CN214021041U (en) | Prevent reducing mechanism for pharmacy that splashes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |