CN106616148A - Hangover-alleviating liver-protecting functional health-care beverage and preparation method thereof - Google Patents

Hangover-alleviating liver-protecting functional health-care beverage and preparation method thereof Download PDF

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Publication number
CN106616148A
CN106616148A CN201611110110.9A CN201611110110A CN106616148A CN 106616148 A CN106616148 A CN 106616148A CN 201611110110 A CN201611110110 A CN 201611110110A CN 106616148 A CN106616148 A CN 106616148A
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Prior art keywords
root
parts
mung bean
extract
kudzu vine
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CN201611110110.9A
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Chinese (zh)
Inventor
林新华
姚宏
廖红婷
徐菁阳
李少光
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Fujian Medical University
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Fujian Medical University
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Publication of CN106616148A publication Critical patent/CN106616148A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/68—Acidifying substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention discloses a hangover-alleviating liver-protecting functional health-care beverage and a preparation method thereof. According to the technical scheme, the hangover-alleviating liver-protecting functional health-care beverage is prepared from the following components in parts by weight: 50 to 200 parts of kudzuvine root extracts, 50 to 200 parts of mung bean extracts, 10 to 25 parts of fructose, 0.005 to 0.3 part of ascorbic acid, 0.005 to 0.3 part of fumaric acid, 0.1 to 0.5 part of succinic acid and 0.0001 to 0.03 part of L-cysteine. The functional beverage provided by the invention can effectively relieve drunkenness symptom and reduce chemical liver injury caused by alcohol.

Description

A kind of Antialcoholic liver-protecting functional health-care drink and preparation method thereof
Technical field
The invention belongs to field of health care products, and in particular to a kind of functional health drink of Antialcoholic liver-protecting.
Background technology
It is drunk, medically it is called acute alcoholism, it is to cause due to once introducing excessive alcohol or inebriant The central nervous system state that switchs to suppress by excitement, show as a series of central nervous system symptom, and to liver, kidney It is dirty to wait human body Chinese medicine internal organs to cause to damage.At present, increasing personage has appreciated that the health problem brought of drinking, and proposes The new ideas that health is drunk.People start more to focus on the effect in terms of food and medicine Antialcoholic liver-protecting, need on market Want one can be with the functional product of Antialcoholic liver-protecting.
The content of the invention
For problem above, the purpose of the present invention is to provide a kind of natural with the root of kudzu vine, mung bean using prior art and resource Plant component extraction thing is major ingredient, addition vitamin and drinks made by amino acid and fructose, and wine can be accelerated when drinking Essence metabolic rate in vivo, mitigates the symptom that the cental system for bringing of drinking suppresses, and reduces the chemically liver damage that alcohol causes Wound.
The technical solution used in the present invention is：A kind of Antialcoholic liver-protecting functional health-care drink, makes by weight ratio：
Kudzu root extract 50-200 parts;
Semen phaseoli radiati extract 50-200 parts;
Fructose 10-25 parts;
Ascorbic acid 0.005-0.3 parts;
Fumaric acid 0.005-0.3 parts;
Butanedioic acid 0.1-0.5 parts;
Cys 0.0001-0.03 parts;
What described kudzu root extract and Semen phaseoli radiati extract was prepared from by following methods：The root of kudzu vine and mung bean are taken, 10 are separately added into Again the water of amount, heats 1h, 100 DEG C of reheating 1h in 80 DEG C of waters bath with thermostatic control, concentrates, filters to obtain the root of kudzu vine, mung bean leaching liquor, and Jing is cold Rear, centrifugation is obtained.
Optimum ratio 1 is：
100 parts of kudzu root extract;
100 parts of Semen phaseoli radiati extract;
18 parts of fructose;
0.1 part of ascorbic acid;
0.12 part of fumaric acid;
0.32 part of butanedioic acid;
0.012 part of Cys.
Optimum ratio 2 is：
200 parts of kudzu root extract;
100 parts of Semen phaseoli radiati extract;
18 parts of fructose;
0.1 part of ascorbic acid;
0.12 part of fumaric acid;
0.32 part of butanedioic acid;
0.012 part of Cys.
Root of kudzu vine legume pueraria lobata or the dry root of sweet kudzu, as a kind of Chinese tradition medicinal material, can promote new old generation Thank, strengthen liver detoxification function, damage of the alcohol to liver is prevented, with very high medical value.The osajins such as Puerarin Effective component, belongs to the natural plants of the medicine-food two-purpose of Ministry of Public Health's approval.
Mung bean rich in nutrition content, containing mung bean protein and amino acid needed by human, with the Li Shui that relieves summer heat, heat-clearing solution The drug actions such as poison, liver-nourishing and eyesight-improving, help vigour, are the food materials of traditional dietotherapeutic.
Fructose is used as sweetener.Simultaneously fructose is added in the product that relieves the effect of alcohol, the multiple efficacies of fructose can be played. Alcoholic hypoglycemia is made up in time；Under liver anaerobic condition still can metabolism, burden of liver is light；Fructose can promote internal alcohol Decompose, suppress protein depletion, reduce the time of staying of the maximum intermediate product acetaldehyde of toxicity.Fructose can also reduce alcohol to liver The anoxia-induced apoptosis of cell, reduce the hepatocellular death of anoxic, and after anoxic is eliminated hepatocellular metabolic capability is recovered in time.
Ascorbic acid（Vitamin C）It is a kind of strong antioxidant, body immunity can be improved, there is protection cell, detoxifies, Liver-protective effect.In vivo sufficient ascorbic acid can remove free radical, prevent lipid peroxidation and some chemical substances Toxic action, the eubolism of liver-protective detoxification ability and cell.
Fumaric acid is used as a kind of food additives --- acid, for cold drink, fruit drops etc..Fumarate is clear Except free radical is discharged in inflammatory process, so as to protect nerve and spongiocyte.
Butanedioic acid is used for the seasoning of wine, feed, candy etc. as acid condiment.It is can use to produce sulfanilamide (SN) in medical industry The Anticonvulsantses such as medicine, vitamin A, Cobastab, loose phlegm agent, diuretics and haemostatic medicament.Pharmacological evaluation prompting has calmness and reduction The effect of body temperature.
Cysteine is a kind of amino acid with physiological function, is also only with reproducibility group sulfydryl (- SH) Amino acid.In vivo have obvolvent effect etc., therefore to poisonous substance in extensive range for example formaldehyde, acetaldehyde, chloroform, carbon tetrachloride, Alcohol etc. has effective detoxication.
The invention has the beneficial effects as follows：The Antialcoholic liver-protecting functional health-care drink of the present invention, can effectively alleviate drunk Symptom, strengthens the ability of organism metabolism alcohol, there is that anti-oxidant, chemical resistance is damaged, removes free radical.The present invention's is excellent Putting is：(1) active ingredient of the present invention by experimental study more than carries out scientific matching according to certain ratio, makes its more preferable Performance its biologically active.(2) Antialcoholic liver-protecting functional health-care drink of the invention is made up of the raw material of medicine-food two-purpose, no Containing the material that pigment, preservative, essence etc. are harmful.(3) active ingredient is made drink by the present invention, is allowed to easily quilt People are received, and are eaten convenient.
Specific embodiment
A kind of Antialcoholic liver-protecting functional health-care drink of embodiment 1
(i) it is made up by important part proportioning of following raw material：
100 parts of kudzu root extract；
100 parts of Semen phaseoli radiati extract；
18 parts of fructose；
0.1 part of ascorbic acid；
0.12 part of fumaric acid；
0.32 part of butanedioic acid；
0.012 part of Cys；
(ii) preparation method is as follows：
It is totally, without the root of kudzu vine, mung bean for going mouldy raw material to select, and the removal wherein impurity such as soil block, stone is cleaned with clear water.Electricity consumption Sub- balance weighs pretreated root of kudzu vine 30g, mung bean 50g, adds the water of 10 times of amounts, heats 1h in 80 DEG C of waters bath with thermostatic control, and 100 DEG C reheat 1h, concentrate, filter to obtain the root of kudzu vine, each 100ml of mung bean leaching liquor.Leaching liquor is poured in Centrifuge Cup, turning with 5000rpm Speed centrifugation 10min, obtains the Chinese medicine extract compared with clear.Said extracted liquid is pressed into 1:1 mixing, obtains the 200ml roots of kudzu vine, green Beans mixed extract, adds fructose 18g, ascorbic acid 0.1g, fumaric acid 0.12g, butanedioic acid 0.32g, Cys 0.012g, stirs.Deployed solution is centrifuged with centrifuge, rotating speed is 1000rpm, 5min is centrifuged, obtain limpid Transparent brown solution.
（Three）Antialcoholic liver-protecting zoopery：
1. experimental animal is selected
Experimental animal selects KM mouse [SCXK (Shanghai) 2012-0002, Shanghai Slac Experimental Animal Co., Ltd.], male, body Quality 20-25g.
2. animal experiment
Experimental group is set, model group and control group, Fen Bie Xian Give mouse stomach 0.1ml/10g alcohol-dissolving liver-protecting drink, physiology salt Water and commercially available alcoholism-relieving liver-protecting product（RU-21 wake up clear）, gavage the white wine of 0.13ml/10g after 30min again, will Mouse is positioned in YLS-1A mouse autonomic activities recorders observes 1h, records the number of activities of every 5min of mouse, as a result such as Table 1.
The alcohol-dissolving liver-protecting drink of table 1 animal is drunk after ethological impact（X±S）
As a result show：The result of number of activities shows, to this beverage experimental group than commercially available positive drug group and negative control group Effect to get well, with experimental group contrast,* P<0.01, illustrate the ability that experimental group can significantly improve autonomic activities after mouse is drunk.
A kind of Antialcoholic liver-protecting functional health-care drink of embodiment 2
(i) it is made up by important part proportioning of following raw material：
200 parts of kudzu root extract；
100 parts of Semen phaseoli radiati extract；
18 parts of fructose；
0.1 part of ascorbic acid；
0.12 part of fumaric acid；
0.32 part of butanedioic acid；
0.012 part of Cys；
(ii) preparation method is as follows：
It is totally, without the root of kudzu vine, mung bean for going mouldy raw material to select, and the removal wherein impurity such as soil block, stone is cleaned with clear water.Electricity consumption Sub- balance weighs pretreated root of kudzu vine 60g, mung bean 50g, adds the water of 10 times of amounts, heats 1h in 80 DEG C of waters bath with thermostatic control, and 100 DEG C reheat 1h, concentrate, filter to obtain the root of kudzu vine, each 100ml of mung bean leaching liquor.Leaching liquor is poured in Centrifuge Cup, turning with 5000rpm Speed centrifugation 10min, obtains the Chinese medicine extract compared with clear.By said extracted liquid by volume 1:1 mixing, obtains 200ml The root of kudzu vine, mung bean mixed extract, add fructose 18g, ascorbic acid 0.1g, fumaric acid 0.12g, the Guang of butanedioic acid 0.32g, L- half Propylhomoserin 0.012g, stirs.Deployed solution is centrifuged with centrifuge, rotating speed is 1000rpm, 5min is centrifuged, obtained Limpid transparent brown solution.
(iii) Antialcoholic liver-protecting zoopery：
1. experimental animal is selected
Experimental animal selects KM mouse [SCXK (Shanghai) 2012-0002, Shanghai Slac Experimental Animal Co., Ltd.], male, body Quality 20-25g.
2. animal experiment
Experiment mice is divided into immediately model group, experimental group and control group, per group of 10 mouse.In gavage life respectively sooner or later daily Reason salt solution, alcohol-decomposing beverage and commercially available positive drug, after 30min, then the white wine of gavage intoxicating dosage, continuous gavage 3 days, after 3 days most Afterwards gavage once, is taken a blood sample after 30min, takes serum, does ELISA kit, alcohol dehydrogenase in detection mouse blood（ADH）And acetaldehyde Dehydrogenase（ALDH）Content.As a result such as table 2, table 3.
Impact of the alcohol-decomposing beverage of table 2 to ADH contents in mice serum（x±s）
Compare with model control group,*P<0.05。
Impact of the alcohol-dissolving liver-protecting drink of table 3 to ALDH contents in mice serum（x±s）
Compare with model control group,*P<0.1。
Experimental group is significantly reduced compared with the value of ADH and ALDH in model control group serum, and prompting can mitigate liver cell damage Wound, makes ADH, ALDH in liver enter blood reduction.
A kind of Antialcoholic liver-protecting functional health-care drink of embodiment 3
(i) it is made up by important part proportioning of following raw material：
100 parts of kudzu root extract；
200 parts of Semen phaseoli radiati extract；
18 parts of fructose；
0.1 part of ascorbic acid；
0.12 part of fumaric acid；
0.32 part of butanedioic acid；
0.012 part of Cys；
(ii) preparation method is as follows：
It is totally, without the root of kudzu vine, mung bean for going mouldy raw material to select, and the removal wherein impurity such as soil block, stone is cleaned with clear water.Electricity consumption Sub- balance weighs pretreated root of kudzu vine 30g, mung bean 100g, adds the water of 10 times of amounts, and in 80 DEG C of waters bath with thermostatic control 1h is heated, 100 DEG C of reheating 1h, concentrate, filter to obtain the root of kudzu vine, each 100ml of mung bean leaching liquor.Leaching liquor is poured in Centrifuge Cup, with 5000rpm Rotating speed centrifugation 10min, obtain the Chinese medicine extract compared with clear.By said extracted liquid by volume 1:1 mixing, obtains The 200ml roots of kudzu vine, mung bean mixed extract, add fructose 18g, ascorbic acid 0.1g, fumaric acid 0.12g, butanedioic acid 0.32g, Cys 0.012g, stirs.Deployed solution is centrifuged with centrifuge, rotating speed is 1000rpm, is centrifuged 5min, obtains limpid transparent brown solution.
(iii) Antialcoholic liver-protecting zoopery：
1. experimental animal is selected
Experimental animal selects KM mouse [SCXK (Shanghai) 2012-0002, Shanghai Slac Experimental Animal Co., Ltd.], male, body Quality 20-25g.
2. animal experiment
Experiment mice is divided into immediately model group and experimental group, per group of 10 mouse.Fen other Xian Give mouse gavaging 0.1ml/10g's Water and alcohol-decomposing beverage, the white wine of gavage 0.13ml/10g after 30min, after 30min, take blood, with gas chromatographic measurement mouse blood Concentration of alcohol.The results are shown in Table 4.
Impact of the Antialcoholic liver-protecting functional beverage of table 4 to ethanol content in mouse blood
Group n Content mg/ml of ethanol in whole blood
Model group 10 4.99±1.16
Experimental group 10 3.71±0.81*
Compared with model group,*P<0.01, it is believed that experimental group is significantly reduced than alcohol levels in blood samples concentration in model group.

Claims (4)

1. a kind of Antialcoholic liver-protecting functional health-care drink, it is characterised in that following proportionings by weight are made：Kudzu root extract 50-200 parts, Semen phaseoli radiati extract 50-200 parts, fructose 10-25 parts, ascorbic acid 0.005-0.3 parts, fumaric acid 0.005-0.3 Part, butanedioic acid 0.1-0.5 parts, Cys 0.0001-0.03 parts；Described kudzu root extract and Semen phaseoli radiati extract are by following What method was prepared from：The root of kudzu vine and mung bean are taken, the water of 10 times of amounts is separately added into, 1h is heated in 80 DEG C of waters bath with thermostatic control, 100 DEG C again Heating 1h, concentrate, filter to obtain the root of kudzu vine, mung bean leaching liquor, after cooling, centrifugation obtain.
2. a kind of Antialcoholic liver-protecting functional health-care drink as claimed in claim 1, it is characterised in that by following weight portion into Divide and make：100 parts of kudzu root extract, 100 parts of Semen phaseoli radiati extract, 18 parts of fructose, 0.1 part of ascorbic acid, 0.12 part of fumaric acid, amber 0.32 part of amber acid, 0.012 part of Cys.
3. a kind of preparation method of Antialcoholic liver-protecting functional health-care drink as claimed in claim 1 or 2, it is characterised in that bag Include following steps：
(1) fructose, ascorbic acid, fumaric acid, butanedioic acid and cysteine are taken by proportioning, it is standby；
(2) the root of kudzu vine and mung bean are taken, the water of 10 times of amounts is separately added into, 1h, 100 DEG C of reheating 1h are heated in 80 DEG C of waters bath with thermostatic control, Concentrate, filter to obtain the root of kudzu vine, mung bean leaching liquor；
(3) step（2）Root of kudzu vine extract is obtained Jing after centrifugation after the root of kudzu vine, the cooling of mung bean leaching liquor of acquisition and mung bean is extracted Liquid, root of kudzu vine extract and mung bean extract are by proportioning and step（1）Standby fructose, ascorbic acid, fumaric acid, butanedioic acid and half Cystine is well mixed, and obtains mixture.
4. a kind of preparation method of Antialcoholic liver-protecting functional health-care drink as claimed in claim 3, it is characterised in that described The root of kudzu vine and mung bean, are separately added into the water of 10 times of amounts, and 1h, 100 DEG C of reheating 1h, concentration, filtration are heated in 80 DEG C of waters bath with thermostatic control Obtain the root of kudzu vine, mung bean leaching liquor.
CN201611110110.9A 2016-12-06 2016-12-06 Hangover-alleviating liver-protecting functional health-care beverage and preparation method thereof Pending CN106616148A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109893629A (en) * 2019-04-17 2019-06-18 王立文 A kind of amber hangover medicine and preparation method thereof

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Publication number Priority date Publication date Assignee Title
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109893629A (en) * 2019-04-17 2019-06-18 王立文 A kind of amber hangover medicine and preparation method thereof

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Application publication date: 20170510