CN106610435B - The control method and control device of autosampler - Google Patents
The control method and control device of autosampler Download PDFInfo
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- CN106610435B CN106610435B CN201510697857.8A CN201510697857A CN106610435B CN 106610435 B CN106610435 B CN 106610435B CN 201510697857 A CN201510697857 A CN 201510697857A CN 106610435 B CN106610435 B CN 106610435B
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- fluid sample
- predetermined time
- autosampler
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- metering pump
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Abstract
The present invention relates to a kind of control method of autosampler, autosampler attracts fluid sample using metering pump and fluid sample is injected into analysis flow path by switching multi-way valve, method includes the following steps: driving measuring pump attracts fluid sample；Wait the predetermined time；Switching multi-way valve makes metering pump and analysis fluid communication.The invention further relates to a kind of control devices of autosampler.
Description
Technical field
The present invention relates to a kind of control method of autosampler and control devices.
Background technique
In the analysis instruments such as liquid chromatograph, there is the sample introduction needle and syringe for attracting fluid sample and measuring
(metering pump) and by switching autosampler of the flow path by the Sample introduction of attraction to analysis flow path.
The autosampler of the prior art can be imported into analysis flow path immediately after syringe attracts sample.Attracting
In the case that speed is than very fast or sample viscosity is bigger, after the completion of syringe attraction movement, fluid sample is in decompression state,
There are also sub-fraction samples not to be attracted in syringe completely, if imported into analysis flow path immediately, will cause measurement knot
Fruit is less than normal.
Summary of the invention
In the prior art this in order to solve the problems, such as, the invention proposes a kind of control method of autosampler and controls
Device processed.
According to an aspect of the present invention, a kind of control method of autosampler, the autosampler utilize metering pump
Attract fluid sample that the fluid sample is simultaneously injected into analysis flow path by switching multi-way valve, wherein the method includes with
Lower step: the metering pump is driven to attract the fluid sample；Wait the predetermined time；Switch the multi-way valve and makes the metering
Pump and the analysis fluid communication.
The predetermined time determines according to the speed of the attraction fluid sample.
The predetermined time determines according to the viscosity of the fluid sample.
The predetermined time satisfies the following conditional expression with the speed for attracting the fluid sample:
Tw=(sa-si) × ct
Wherein tw is the predetermined time, and sa is the speed for attracting the fluid sample, and si is initial velocity, and ct is the time
Coefficient.
The predetermined time and the viscosity of the fluid sample satisfy the following conditional expression:
Tw=(vs-vi) × cv
Wherein tw is the predetermined time, and vs is the viscosity of the fluid sample, and vi is initial viscosity, and cv is viscosity system
Number.
According to another aspect of the present invention, a kind of control device of autosampler is additionally provided.
Invention effect
It can be complete by sample due to increasing the waiting time after attracting sample using method and device of the invention
It is attracted in syringe, therefore can be improved the accuracy of analysis result.
Detailed description of the invention
Fig. 1 is the schematic diagram of the control method of embodiment according to the present invention.
Fig. 2 is the schematic diagram of the control device of embodiment according to the present invention
Specific embodiment
The present invention will be described referring to the drawings.
Autosampler mainly includes multi-way valve, and the components such as metering pump pass through the company between each port of multi-way valve
The switching of clearance system is completed to attract fluid sample and fluid sample is directed into analysis flow path.
Illustrate the control method of autosampler according to the present invention referring to Fig. 1.As shown in Figure 1, according to this hair
Bright method attracts fluid sample to wait for a period of time after attracting sample first with metering pump, then passes through switching again
The fluid sample of attraction is imported analysis flow path by multi-way valve.By the way that the waiting time is arranged, the liquid in decompression state is enabled to
Body sample restores pressure, so that the measured pump of the sample of designated capabilities attracts completely.
The time of waiting can determine that the relationship of the two is satisfied the following conditional expression according to the attraction speed of fluid sample
(1):
Tw=(sa-si) × ct (1)
Wherein, tw is the waiting time, and sa is the attraction speed of fluid sample, and si is initial velocity, and ct is waiting time system
Number.Initial velocity is the attraction velocity amplitude withouted waiting for obtained according to experiment, and the waiting time, coefficient was according to autosampler
Self-characteristic determine.By conditional (1) it is found that attracting speed faster, the waiting time is longer.
In addition, the time waited can also determine that the relationship of the two meets the following conditions according to the viscosity of fluid sample
Formula (2):
Tw=(vs-vi) × cv (2)
Wherein, tw is the waiting time, and vs is the viscosity of fluid sample, and vi is initial viscosity, and cv is to wait viscosity coefficient.Just
Beginning viscosity is the viscosity number of the fluid sample withouted waiting for obtained according to experiment, and waiting viscosity coefficient is according to automatic sampling
Fixed value determined by the characteristic of device and fluid sample.By conditional (2) it is found that sample viscosity is bigger, the waiting time is longer.
Using method of the invention, due to increasing the waiting time after attracting sample, sample can be attracted to completely
In syringe, therefore it can be improved the accuracy of analysis result.
Illustrate the control device of autosampler according to the present invention referring to Fig. 2.As shown in Fig. 2, according to this hair
Bright control device includes drive module, timing module and switching module.Drive module is acted for driving measuring pump, thus
Attract fluid sample, after drive module driving measuring pump attracts fluid sample, timing module is calculated according to the above conditions
Waiting time starts countdown, and after countdown terminates to have passed through the waiting time, switching module switches multi-way valve, so that
Metering pump and analysis fluid communication, and then the fluid sample attracted can be imported into analysis flow path.
Control device according to the present invention can instruct relevant hardware to complete by computer program, the journey
Sequence can be stored in computer-readable storage medium, which when being executed, completes above-mentioned method flow.Wherein, described
Storage medium can be disk, CD, read-only memory (Read-Only Memory, ROM) or random access memory
(Random Access Memory, RAM) etc..
It is not for limiting the present invention, any affiliated technology although the present invention has been disclosed as a preferred embodiment
The technical staff in field can make fraction of change and retouching, therefore the present invention without departing from the spirit and scope of the present invention
Protection scope be subject to what claim was defined.
Claims (6)
1. a kind of control method of autosampler, the autosampler attracts fluid sample using metering pump and passes through switching
The fluid sample is injected into analysis flow path by multi-way valve, which is characterized in that the described method comprises the following steps:
The metering pump is driven to attract the fluid sample；
The predetermined time is calculated according to the viscosity of the speed or the fluid sample that attract the fluid sample；
After having attracted the fluid sample, institute's calculated predetermined time is waited；
After waiting the predetermined time, switches the multi-way valve and make the metering pump and the analysis fluid communication.
2. the method as described in claim 1, which is characterized in that
The predetermined time determines according to the speed of the attraction fluid sample.
3. the method as described in claim 1, which is characterized in that
The predetermined time determines according to the viscosity of the fluid sample.
4. method according to claim 2, which is characterized in that
The predetermined time satisfies the following conditional expression with the speed for attracting the fluid sample:
Tw=(sa-si) × ct
Wherein tw is the predetermined time, and sa is the speed for attracting the fluid sample, and si is initial velocity, and ct is time system
Number.
5. method as claimed in claim 3, which is characterized in that
The predetermined time and the viscosity of the fluid sample satisfy the following conditional expression:
Tw=(vs-vi) × cv
Wherein tw is the predetermined time, and vs is the viscosity of the fluid sample, and vi is initial viscosity, and cv is viscosity coefficient.
6. a kind of control device of autosampler, the autosampler attracts fluid sample using metering pump and passes through switching
The fluid sample is injected into analysis flow path by multi-way valve, which is characterized in that the control device includes
The metering pump is driven to attract the driving device of the fluid sample；
The time set of predetermined time is calculated according to the viscosity of the speed or the fluid sample that attract the fluid sample；
After having attracted the fluid sample, institute's calculated predetermined time is waited, after waiting the predetermined time, is cut
Change the switching device that the multi-way valve makes the metering pump and the analysis fluid communication.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510697857.8A CN106610435B (en) | 2015-10-23 | 2015-10-23 | The control method and control device of autosampler |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510697857.8A CN106610435B (en) | 2015-10-23 | 2015-10-23 | The control method and control device of autosampler |
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| Publication Number | Publication Date |
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| CN106610435A CN106610435A (en) | 2017-05-03 |
| CN106610435B true CN106610435B (en) | 2019-11-29 |
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| CN201510697857.8A Active CN106610435B (en) | 2015-10-23 | 2015-10-23 | The control method and control device of autosampler |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102695957A (en) * | 2010-01-13 | 2012-09-26 | 株式会社日立高新技术 | Automatic analyzing device |
| CN103890589A (en) * | 2011-10-18 | 2014-06-25 | 株式会社日立高新技术 | Automated analyzer |
| CN103930778A (en) * | 2011-03-23 | 2014-07-16 | 明尼苏达大学评议会 | Valve and splitting system for multi-dimensional liquid analysis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5736457B2 (en) * | 2011-07-08 | 2015-06-17 | 株式会社日立ハイテクノロジーズ | Solid phase extraction device |
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2015
- 2015-10-23 CN CN201510697857.8A patent/CN106610435B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102695957A (en) * | 2010-01-13 | 2012-09-26 | 株式会社日立高新技术 | Automatic analyzing device |
| CN103930778A (en) * | 2011-03-23 | 2014-07-16 | 明尼苏达大学评议会 | Valve and splitting system for multi-dimensional liquid analysis |
| CN103890589A (en) * | 2011-10-18 | 2014-06-25 | 株式会社日立高新技术 | Automated analyzer |
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| Publication number | Publication date |
|---|---|
| CN106610435A (en) | 2017-05-03 |
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