CN106581843A - Vaginal and anorectal drug delivery carrier with high retaining property and high permeability - Google Patents
Vaginal and anorectal drug delivery carrier with high retaining property and high permeability Download PDFInfo
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- CN106581843A CN106581843A CN201710057531.8A CN201710057531A CN106581843A CN 106581843 A CN106581843 A CN 106581843A CN 201710057531 A CN201710057531 A CN 201710057531A CN 106581843 A CN106581843 A CN 106581843A
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- bombyx bombycis
- vagina
- anorectal
- permeability
- bracing wire
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Absorbent Articles And Supports Therefor (AREA)
Abstract
The invention discloses a vaginal and anorectal drug delivery carrier with high retaining property and high permeability, relates to a pharmaceutical preparation taking special characters as features, and in particular relates to a carrier for vaginal and anorectal drug delivery. The invention aims to provide a vaginal and anorectal drug delivery carrier with high retaining property and high permeability which is simple in structure, low in cost, easy and convenient to use and high in comfort level. The vaginal and anorectal drug delivery carrier with high retaining property and high permeability disclosed by the invention comprises a silkworm cocoon and a bracing wire. In the process of implanting the vaginal and anorectal drug delivery carrier with high retaining property and high permeability disclosed by the invention into the vagina or anus, the loaded liquid medicine or drug composition in other states is not extruded so as not to cause liquid medicine loss, the retaining property is high after implantation in the vagina or anus, a sustained-release effect can be formed, that is, the drug can be easily placed or taken out, and enough drug loading capacity can be guaranteed. The vaginal and anorectal drug delivery carrier disclosed by the invention is applied to the field of medicines.
Description
Technical field
The present invention relates to a kind of pharmaceutical product being characterized with specialized character, more particularly to a kind of to be used for vagina, anus
The carrier of enteral administration.
Background technology
Carried as liquid or thin ointment vagina, anorectal administration using bracing wire cotton balls or bracing wire sponge more than prior art
Body, its protrusion has the disadvantage when vagina or anorectal is plunged into, because the natural deflation effect of vaginal orifice or anus can be by cotton balls
Or most of liquid for being held of sponge or thin ointment extrusion, finally the remaining nothing of the medicinal liquid of vagina or anus is brought into by cotton balls
It is several；Prior art uses merely the excipient such as cream, bolt, glue as the carrier of medicinal ingredient, there is mastic or holds after suppository dissolves
Easily flow out or slide external shortcoming.In a word, there is medicine and be easy to run off or in vivo in existing vagina or anorectal drug administration carrier technology
Hold the defect of medicine deficiency of time.The present invention is in order to overcome the deficiencies in the prior art, it is proposed that a kind of to insert vagina or anus
During will not make fluid loss, insert performance is held after vagina or anus more preferably and slow releasing function and carrier itself can be formed
Vagina with medicinal function, anorectal drug administration carrier.
The content of the invention
The technical problem to be solved in the present invention is to provide the high tool of a kind of simple structure, low cost, easy to use, comfort level
Have vagina, an anorectal drug administration carrier of high holding property and high-permeability, the drug administration carrier during vagina or anus is inserted not
The ingredient of contained medicinal liquid or other states extrusion can be caused fluid loss, insert vagina or anus after to hold performance more preferable
And slow releasing function can be formed, that is, it is easy to place and take out and can ensure enough drug loading.
The present invention relates to a kind of new application of Bombyx bombycis, the Bombyx bombycis are natural Bombyx bombycis or artificial Bombyx bombycis, and the Bombyx bombycis are used as
The drug administration carrier of vagina, anorectal.
The invention further relates to a kind of vagina with holding property of height and high-permeability, anorectal drug administration carrier, the carrier bag
Include drug loaded device and bracing wire；The drug loaded device is for a Bombyx bombycis or by two Bombyx bombycis boil on the nape opposite the mouth socket (clamping in other words)
Into drug loaded device is closing after the Bombyx bombycis socket of two openings；
The Bombyx bombycis are natural Bombyx bombycis or artificial Bombyx bombycis；Such as need to possess speciality and the spy of natural Bombyx bombycis using artificial Bombyx bombycis
Property, in order to increase the cocoon ash that medicinal function Bombyx bombycis surface can be adhered to after silk burns；When Bombyx bombycis are natural Bombyx bombycis, Bombyx bombycis are removal
Bombyx bombycis after pupa；
When drug loaded device is single Bombyx bombycis, the bracing wire pulls Bombyx bombycis after inserting in vivo for drug loaded device；
When drug loaded device is socketed to form by two Bombyx bombycis, the bracing wire is fixation for two wearing for Bombyx bombycis, or is used for
Two wearing for Bombyx bombycis are to fix simultaneous pulling.
Preferably, the carrier also includes implant, and the implant is with load medicine function or has medicinal function concurrently
Material, the state of carrier can be the material of solid, powder body, mastic, colloid, frost, liquid or other nondeterministic statements；It is described to fill out
Thing is filled including one or more in high-hydroscopicity supporting body, excipient, common drug solvent；
The implant is located in Bombyx bombycis or is attached to Bombyx bombycis housing.
Preferably, the high-hydroscopicity supporting body includes that natural fiber (including cotton balls and gauze etc.), chemical fibre are (artificial
Fiber or synthetic fibers), other natural high-hydroscopicity materials, other synthesis macromolecule water uptake materials in one or more；Institute
Excipient is stated including the one kind or many in vaseline (a kind of mineral wax), lanoline, plant gum, pectin, other usual excipients
Kind；The common drug solvent includes one or more in water, ethanol, glycerol.
Preferably, described other natural high-hydroscopicity materials are included in Endoconcha Sepiae (Os Sepiae) powder, natural sponge, coral powder
One or more；Described other synthesis macromolecule water uptake materials include one or two in sponge, hydroscopic high-molecular resin；
Described other usual excipients include one or more in frost, ointment, emulsifiable paste.
Preferably, when the drug loaded device is a Bombyx bombycis, Bombyx bombycis are open or remain silent；The drug loaded device is by two
When individual Bombyx bombycis clamping is formed, Bombyx bombycis are opening, and drug loaded device is closing after the Bombyx bombycis socket of two openings.
Preferably, the bracing wire is made up of soft material.
Preferably, the bracing wire is pulled out by the silkworm silk of Bombyx bombycis itself and twisted into.
Preferably, the bracing wire is made up of cotton thread or synthetic material.
Preferably, the bracing wire is provided with sticking tablet, for bracing wire to be fixed on into vagina or anorectal outer skin.
The present invention has in vagina, the technical scheme of anorectal drug administration carrier of high holding property and high-permeability with natural Bombyx bombycis
As the capsid of drug administration carrier, many natural characteristics of Bombyx bombycis are cleverly make use of, including its medical value, physical characteristics etc.,
It is specific as follows：
1st, the present invention has in vagina, the anorectal drug administration carrier of high holding property and high-permeability using natural Bombyx bombycis as giving
Medicine device, because it is oval, is about 3-5cm, diameter 1.5-2.5cm, and with certain hardness, its shapes and sizes is all
It is particularly suitable for being used as vagina, anorectal drug administration carrier；Employ the carrier of natural Bombyx bombycis and insert vagina or anus
During the ingredient of contained medicinal liquid or other states extrusion will not be caused fluid loss, insert vagina or anus after hold
Performance is more preferable and can form slow releasing function, that is, be easy to place and take out and can ensure enough drug loading.
2nd, harder when natural Bombyx bombycis are dry, wet rear softening is without obvious foreign body sensation and relatively comfortable when retaining in vivo.
3rd, the cocoon shell of natural Bombyx bombycis it is stiff and it is wet it is soft in the state of fibrous layer it is all fine and close solid, He Qibi wears seam
Bracing wire firmly resistance to drawing, carrier is difficult off-line
4th, there is the fine and close solid cocoon shell of silkworm silk the solid fillers such as preferable tension force and solid ability, cotton balls, sponge to fill
It is full wherein to keep intrinsic shape, with preferably holding property；Also there is appearance ability of preferably receiving to the implant of other states,
And cocoon shell adsorptivity and permeability are very well, can slowly discharge ingredient and carry out fluid exchange so as to prolong with the outer body fluid of shell
The action time of long administration
5th, vagina, anal and intestinal disease it is many with plicate inflammation, fester and bleeding, and making containing silkworm of adopting in the present invention
The Bombyx bombycis of secreted active substance and silkworm silk during cocoon, traditional medicine books record it has convergence, hemostasis, granulation promoting etc. to act on,
These effect can with cocoon shell in hold medication generation synergism, be greatly improved the curative effect of medication.
6th, the present invention is easy to draw materials, and processing technology thereof is simple, easy to use.
7th, it is natural in artificial Bombyx bombycis surface attachment when technical scheme is using the artificial Bombyx bombycis for copying natural Bombyx bombycis
Cocoon after silk burns is grey, can equally reach the effect above.
The vagina with holding property of height and high-permeability, anorectal administration load below by way of drawings and Examples to the present invention
Body is further described.
Description of the drawings
Fig. 1 is vagina, the structural representation of anorectal drug administration carrier in embodiment 1 with high holding property and high-permeability；
Fig. 2 is vagina, the structural representation of anorectal drug administration carrier in embodiment 2 with high holding property and high-permeability；
Fig. 3 is vagina, the structural representation of anorectal drug administration carrier in embodiment 3 with high holding property and high-permeability；
Fig. 4 is vagina, the structural representation of anorectal drug administration carrier in embodiment 4 with high holding property and high-permeability；
Fig. 5 is vagina, the structural representation of anorectal drug administration carrier in embodiment 10 with high holding property and high-permeability；
Fig. 6 is vagina, the structural representation of anorectal drug administration carrier in embodiment 17 with high holding property and high-permeability；
Wherein, 1- Bombyx bombycis, 2- bracing wires, 3- implants, 4- sticking tablets.
Specific embodiment
Embodiment 1
As shown in figure 1, the vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier include：Silkworm
Cocoon 1, implant 3, bracing wire 2 and sticking tablet 4；
Bombyx bombycis 1 are natural Bombyx bombycis, and with opening；
Implant 3 is (high-hydroscopicity supporting body) cotton balls (belonging to natural fiber)；
Bracing wire 2 is cotton thread, and bracing wire 2 initially passes through cotton balls, the outer wall of Bombyx bombycis 1 is then penetrated and penetrated by the opening of Bombyx bombycis 1, then wears
Cross the outer wall of Bombyx bombycis 1 to wear back in Bombyx bombycis 1, bracing wire 2 continues across cotton balls and passed by the opening of Bombyx bombycis 1, and now bracing wire 2 is in Bombyx bombycis 1
Two free ends are reserved at opening；After inserting in vivo for drug loaded device, by pulling bracing wire 2 Bombyx bombycis 1 are taken out；
During the penetrating of above-mentioned bracing wire 2, cotton balls is located at outside Bombyx bombycis 1, completes after aforesaid operations the opening by Bombyx bombycis 1 by cotton balls
Fill at mouthful, this is because the pin of band wire is difficult through the cotton balls for stoppering then to be difficult to complete aforesaid operations；
Two free ends of bracing wire 2 are both secured on sticking tablet 4, and sticking tablet 4 is used to for bracing wire 2 to be fixed on vagina or anorectal
In outer skin.
When using, carrier is dipped in into medicinal liquid (or ointment), makes carrier be loaded with medicinal liquid (or fluid ointment), fully carrying will after medicine
It sends into vagina or anorectal, and bracing wire 2 is stayed in external, sticking tablet 4 is pasted near vagina or anorectal on skin.
Embodiment 2
As shown in Fig. 2 the vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier include：Carry
Medicine device and bracing wire 2；Drug loaded device is a Bombyx bombycis 1；Bombyx bombycis 1 are natural Bombyx bombycis, and with opening；Bracing wire 2 be cotton thread, bracing wire
2 one end is fixed on Bombyx bombycis 1, and the other end is free end, after inserting in vivo for drug loaded device, Bombyx bombycis 1 is pulled during taking-up；
With embodiment 1 except that, bracing wire single line is penetrated by the blind end of Bombyx bombycis 1 and passed by point of proximity after knotting,
Stay single line free end or single line penetrate after pass retained two-wire Jing and knot or omit the free end that knots as bracing wire.
Using method is with embodiment 1.
Embodiment 3
As shown in figure 3, the vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier include：Carry
Medicine device and bracing wire 2；Drug loaded device is a Bombyx bombycis 1；Bombyx bombycis 1 are natural Bombyx bombycis, and with opening；Bracing wire 2 be cotton thread, bracing wire
2 one end is fixed on Bombyx bombycis 1, and the other end is free end, after inserting in vivo for drug loaded device, Bombyx bombycis 1 is pulled during taking-up；
With embodiment 1 except that, bracing wire single line knot after thread a needle to be gone out by opposite side in the side at the edge of opening
Pin and stay bracing wire free end or single line penetrate after pass retained two-wire Jing and knot or omit the freedom that knots as bracing wire
End.
Using method is with embodiment 1.
Embodiment 4
As shown in figure 4, the vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier include：Carry
Medicine device and bracing wire 2；Drug loaded device is a Bombyx bombycis 1；Bombyx bombycis 1 are natural Bombyx bombycis, and with opening；Bracing wire 2 is Bombyx bombycis wire drawing
After twist into, after inserting in vivo for drug loaded device, Bombyx bombycis 1 are pulled during taking-up；
Other with embodiment 1
Embodiment 5
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 1 it
Place is：Bracing wire is (synthetic material) rubber.
Embodiment 6
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 1 it
Place is：Implant 3 is (high-hydroscopicity supporting body) sponge, and bracing wire is (synthetic material) silica gel rubber band.
Embodiment 7
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier difference from Example 1
It is：Implant 3 is (high-hydroscopicity supporting body) natural sponge.
Embodiment 8
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 1 it
Place is：Implant 3 is (high-hydroscopicity supporting body) gauze.
Embodiment 9
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 1 it
Place is：Implant 3 is (high-hydroscopicity supporting body) staple fibre.
Embodiment 10
As shown in figure 5, the vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier include：Carry
Medicine device, bracing wire 2 and sticking tablet 4；Drug loaded device is socketed to form by two clipped half elliptic Bombyx bombycis boil on the nape opposite the mouth；After socket
Cocoon shell be remain silent or say be closing；
Bracing wire 2 is cotton thread, and cotton thread single line is penetrated after knotting by one end of drug loaded device, and the other end knots after passing and makes two
It is fixation that the Bombyx bombycis of socket are worn, and it is that back guy leaves a segment length to wear, or from the other end after single line is penetrated from one end (top)
Pass and penetrate knot after return top is passed retained single line or two-wire from another point at this end again as the free end of bracing wire, be used for
After drug loaded device is inserted in vivo, Bombyx bombycis 1 are pulled during taking-up；It through wearing is method that this is；
The free end of bracing wire 2 is provided with sticking tablet 4, for bracing wire 2 to be fixed on into vagina or anorectal outer skin.
When using, fluid-filled thing is injected in the cocoon shell (Bombyx bombycis 1) of closing, now Bombyx bombycis 1 are loaded with fluid-filled thing, will
Bombyx bombycis 1 are sent in vagina or anorectal, and bracing wire 2 is stayed in external, and sticking tablet 4 is pasted near vagina or anorectal on skin.
Embodiment 11
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 10 it
Place is：There is implant 3 in the Bombyx bombycis 1 of the present embodiment, implant 3 is (excipient) vaseline.
Embodiment 12
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 10 it
Place is：There is implant 3 in the Bombyx bombycis 1 of the present embodiment, implant 3 is (excipient) lanoline.
Embodiment 13
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 10 it
Place is：There is implant 3 in the Bombyx bombycis 1 of the present embodiment, implant 3 is (excipient) vanishing cream.
Embodiment 14
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 10 it
Place is：There is implant 3 in the Bombyx bombycis 1 of the present embodiment, implant 3 is (excipient) pectin.
Embodiment 15
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 10 it
Place is：There is implant 3 in the Bombyx bombycis 1 of the present embodiment, implant 3 is (excipient) plant gum.
Embodiment 16
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 10 it
Place is：There is implant 3 in the Bombyx bombycis 1 of the present embodiment, implant 3 is (common drug solvent) water, ethanol, glycerol.
Embodiment 17
As shown in fig. 6, the vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier include：Carry
Medicine device, bracing wire 2 and sticking tablet 4；Drug loaded device is socketed to form by two clipped boil on the nape opposite the mouth of half elliptic Bombyx bombycis 1；Socket
Cocoon shell afterwards is remained silent or says it is closing.
Bracing wire 2 is cotton thread, and cotton thread single line is penetrated after knotting by one end of drug loaded device, and the other end knots after passing and makes two
It is fixation that the Bombyx bombycis of socket are worn, wear be after do not stay free end, or pass again from the other end after single line is penetrated from one end (top)
Penetrate after return top is passed from another point at this end and knot the free end that do not stay, this be bracing wire do not stay free end be through wearing
Method；
When using, two clipped half elliptic Bombyx bombycis 1 are filled into boil on the nape opposite the mouth after the powder filled thing of water absorption and is socketed into envelope
The capsule shape closed；It is that medicinal liquid is soaked in after bracing wire to wear, and will be adsorbed with the carrier of medicinal liquid and sends in vagina or anorectal, during taking-up
Vagina is stretched into handss or by means of utensil or anus takes out.
Embodiment 18
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 17 it
Place is：Specify that implant is (high-hydroscopicity supporting body) Endoconcha Sepiae powder.
Embodiment 19
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 17 it
Place is：Implant is (high-hydroscopicity supporting body) coral powder.
Embodiment 20
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 17 it
Place is：Implant is (high-hydroscopicity supporting body) hydroscopic high-molecular resin；
Embodiment 21
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier are different from embodiment 1-20
Part be：Bombyx bombycis 1 are artificial Bombyx bombycis, with the physical property that natural Bombyx bombycis are similar to.
Embodiment 22
The vagina with holding property of height and high-permeability of the present embodiment, anorectal drug administration carrier it is different from embodiment 21 it
Place is：Cocoon ash after the natural silk of artificial Bombyx bombycis surface attachment burns so as to the pharmacologically active similar to natural Bombyx bombycis
And effect.
The vagina with holding property of height and high-permeability, anorectal drug administration carrier in above example can with used aloned,
Can also be multiple while using.
Although the foregoing describing the specific embodiment of the present invention, it will be appreciated by those of skill in the art that these
It is merely illustrative of, protection scope of the present invention is defined by the appended claims.Those skilled in the art is not carrying on the back
On the premise of the principle and essence of the present invention, various changes or modifications can be made to these embodiments, but these are changed
Protection scope of the present invention is each fallen within modification.
Claims (10)
1. a kind of new application of Bombyx bombycis, it is characterised in that：The Bombyx bombycis are natural Bombyx bombycis or artificial Bombyx bombycis, and the Bombyx bombycis are used as the moon
The drug administration carrier in road, anorectal.
2. a kind of vagina with holding property of height and high-permeability, anorectal drug administration carrier, it is characterised in that：The carrier includes carrying
Medicine device and bracing wire；The drug loaded device is single Bombyx bombycis or is socketed to form by two Bombyx bombycis；
The Bombyx bombycis are natural Bombyx bombycis or artificial Bombyx bombycis；
When drug loaded device is single Bombyx bombycis, the bracing wire is used to pull Bombyx bombycis；
When drug loaded device is socketed to form by two Bombyx bombycis, the bracing wire is fixation for two wearing for Bombyx bombycis, or for two
Wearing for Bombyx bombycis is to fix simultaneous pulling.
3. the vagina with holding property of height and high-permeability according to claim 2, anorectal drug administration carrier, its feature exists
In：The carrier also includes implant, and the implant is included in high-hydroscopicity supporting body, excipient, common drug solvent
One or more；
The implant is located in Bombyx bombycis or is attached to Bombyx bombycis housing.
4. the vagina with holding property of height and high-permeability according to claim 3, anorectal drug administration carrier, its feature exists
In：The high-hydroscopicity supporting body includes natural fiber, chemical fibre, other natural high-hydroscopicity materials, other synthesis high scores
One or more in sub- absorbent material；The excipient includes vaseline, lanoline, plant gum, pectin, other conventional figurations
One or more in agent；The common drug solvent includes one or more in water, ethanol, glycerol.
5. the vagina with holding property of height and high-permeability according to claim 4, anorectal drug administration carrier, its feature exists
In：Described other natural high-hydroscopicity materials include one or more in Endoconcha Sepiae powder, natural sponge, coral powder；It is described its
He synthesizes macromolecule water uptake material including one or two in sponge, hydroscopic high-molecular resin；Described other usual excipients
Including one or more in frost, ointment, emulsifiable paste.
6. the vagina with holding property of height and high-permeability, the anus according to any one claim in claim 2-5
Enteral administration carrier, it is characterised in that：When the drug loaded device is single Bombyx bombycis, Bombyx bombycis are open or remain silent；The load medicine
When device is socketed (clamping in other words) and forms by two Bombyx bombycis, Bombyx bombycis are opening, the Bombyx bombycis socket rear bearing medicines dress of two openings
It is set to closing.
7. the vagina with holding property of height and high-permeability, the anus according to any one claim in claim 2-5
Enteral administration carrier, it is characterised in that：The bracing wire is pulled out by the silkworm silk of Bombyx bombycis itself and twisted into.
8. the vagina with holding property of height and high-permeability, the anus according to any one claim in claim 2-5
Enteral administration carrier, it is characterised in that：The bracing wire is made up of soft material.
9. the vagina with holding property of height and high-permeability, the anorectal according to any one claim in claim 8
Drug administration carrier, it is characterised in that：The bracing wire is made up of cotton thread or synthetic material.
10. the vagina with holding property of height and high-permeability, the anus according to any one claim in claim 2-5
Enteral administration carrier, it is characterised in that：The bracing wire is provided with sticking tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710057531.8A CN106581843A (en) | 2017-01-26 | 2017-01-26 | Vaginal and anorectal drug delivery carrier with high retaining property and high permeability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710057531.8A CN106581843A (en) | 2017-01-26 | 2017-01-26 | Vaginal and anorectal drug delivery carrier with high retaining property and high permeability |
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| CN106581843A true CN106581843A (en) | 2017-04-26 |
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| CN201710057531.8A Pending CN106581843A (en) | 2017-01-26 | 2017-01-26 | Vaginal and anorectal drug delivery carrier with high retaining property and high permeability |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106958042A (en) * | 2017-05-25 | 2017-07-18 | 东莞质研工业设计服务有限公司 | Silk cocoon expansion structure |
| CN106958042B (en) * | 2017-05-25 | 2019-06-14 | 东莞质研工业设计服务有限公司 | Silk cocoon expansion structure |
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Application publication date: 20170426 |