CN106581490A - Ointment-shaped content softgel and preparation method thereof - Google Patents
Ointment-shaped content softgel and preparation method thereof Download PDFInfo
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- CN106581490A CN106581490A CN201611193514.9A CN201611193514A CN106581490A CN 106581490 A CN106581490 A CN 106581490A CN 201611193514 A CN201611193514 A CN 201611193514A CN 106581490 A CN106581490 A CN 106581490A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 53
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 32
- 238000003756 stirring Methods 0.000 claims abstract description 31
- 239000002775 capsule Substances 0.000 claims abstract description 29
- 108010010803 Gelatin Proteins 0.000 claims abstract description 27
- 241000241413 Propolis Species 0.000 claims abstract description 27
- 229920000159 gelatin Polymers 0.000 claims abstract description 27
- 239000008273 gelatin Substances 0.000 claims abstract description 27
- 235000019322 gelatine Nutrition 0.000 claims abstract description 27
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 27
- 229940069949 propolis Drugs 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 235000001014 amino acid Nutrition 0.000 claims abstract description 17
- 150000001413 amino acids Chemical class 0.000 claims abstract description 17
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 16
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 16
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 16
- 229940046009 vitamin E Drugs 0.000 claims abstract description 16
- 239000011709 vitamin E Substances 0.000 claims abstract description 16
- 239000000049 pigment Substances 0.000 claims abstract description 14
- 238000000605 extraction Methods 0.000 claims abstract description 13
- 238000007689 inspection Methods 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000008188 pellet Substances 0.000 claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 8
- 238000005498 polishing Methods 0.000 claims abstract description 8
- 238000004806 packaging method and process Methods 0.000 claims abstract description 7
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims abstract description 6
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims abstract description 5
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims abstract description 5
- 235000020778 linoleic acid Nutrition 0.000 claims abstract description 5
- 239000007901 soft capsule Substances 0.000 claims description 85
- 239000011265 semifinished product Substances 0.000 claims description 30
- 239000002674 ointment Substances 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 25
- 239000000047 product Substances 0.000 claims description 17
- 239000012530 fluid Substances 0.000 claims description 15
- 210000000582 semen Anatomy 0.000 claims description 15
- 239000003292 glue Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 235000019198 oils Nutrition 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 6
- 238000005422 blasting Methods 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 5
- 239000000428 dust Substances 0.000 claims description 5
- 239000002932 luster Substances 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 4
- 241000256844 Apis mellifera Species 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 5
- 230000001055 chewing effect Effects 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 2
- 238000005453 pelletization Methods 0.000 abstract 2
- 239000010497 wheat germ oil Substances 0.000 abstract 2
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Natural Medicines & Medicinal Plants (AREA)
- Insects & Arthropods (AREA)
- Engineering & Computer Science (AREA)
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Abstract
The invention provides an ointment-shaped content softgel and a preparation method thereof. The ointment-shaped content softgel comprises a capsule shell and a content, and the capsule shell is made by adopting gelatin as a main material and adding water, glycerin and a pigment; and the content is obtained through adopting propolis as a main material, adding wheat germ oil, vitamin E, amino acids and linoleic acid, and mixing and stirring the propolis, wheat germ oil, vitamin E, amino acids and linoleic acid. The preparation method comprises the following steps: pelletizing a solution obtained through extraction using supercritical CO2 as an extraction agent by a pelletizing machine, drying obtained pellets, polishing the dried pellets, carrying out lamp inspection, and carrying out choosing and packaging to obtain the ointment-shaped content softgel. The method has the advantages of simple steps, easiness in operation and convenience in preparation; and the softgel has the advantages of high stability, easiness in chewing, high strength,, realization of long-term stable keeping of the content, easiness in storage, low cost, and meeting of demands of manufacturers.
Description
Technical field
The present invention relates to soft capsule technical field, particularly a kind of ointment shape content composition soft capsule and preparation method thereof.
Background technology
Soft capsule belongs to a kind of manner of packing of capsule, is common in medicine or health food.It is by liquid medicine or
Juicy fruit body medicine Jing process be sealed in soft capsule material and made by a kind of capsule.Soft capsule material is by gelatinum pro capsulae, sweet
Oily or other suitable pharmaceutic adjuvants are independent or are mixed.Soft capsule is referred to directly encapsulates a certain amount of liquid medicine, or
Solid drugs are dissolved or dispersed in suitable excipient and make solution, suspension, emulsion or semisolid, be sealed in it is spherical or
Capsule in oval soft capsule material.The intracapsular content of existing flexible glue is carried out after moisture absorption to softgel shell, makes softgel shell hardness
It is higher, it is unfavorable for the chewing of user, soft capsule preparation process in preparation process is loaded down with trivial details, relatively costly, can not meet producer
Demand.
The content of the invention
Problem to be solved by this invention is to provide a kind of ointment shape content composition soft capsule and preparation method thereof, solves existing
Flexible glue intracapsular content softgel shell is carried out after moisture absorption, make softgel shell hardness higher, be unfavorable for the chewing of user, soft capsule exists
Preparation process is loaded down with trivial details in preparation process, relatively costly, can not meet the problem of the demand of producer.
To solve problem above scheme of the present invention：
A kind of ointment shape content composition soft capsule and preparation method thereof, wherein, a kind of ointment shape content composition soft capsule include softgel shell with
Content, its preparation method is as follows：
（1）It is prepared by capsule shell fluid：1. gelatin 100-300g, water 100-300g, glycerol 40-120g and pigment 0.1-0.3g are weighed；②
First water is poured in pot with glycerol and is at the uniform velocity stirred, until after temperature is raised to 75-90 DEG C, add gelatin to continue to stir 30-50min,
Obtain gelatin solution；3. after pigment stirring 5-10min is added in gelatin solution, you can obtain capsule shell fluid；
（2）It is prepared by content：1. the propolis 32-96g of selected high-quality, Semen Tritici aestivi germ oil 60-180g, Vitamin E 4-12g, amino
Sour 1-3g and linoleic acid 3-9g；2. propolis is poured in extraction kettle, is extracted by extractant of supercritical CO 2, extracting pressure
For 30-45MPa, temperature be 80-90 DEG C, supercritical CO 2 flow velocity be 18～25L/h, extraction time is 0.5-1.5h, obtain propolis surpass
Critical CO2 extracts；3. Semen Tritici aestivi germ oil is poured in pot and is at the uniform velocity stirred when temperature rises to 60-75 DEG C, added propolis to surpass and face
CO2 extracts in boundary continue to stir addition Vitamin E stirring 5-15min after 30-45min, and can obtain mixed liquor A；4. to mixed liquor A
In sequentially add aminoacid and at the uniform velocity stir with linoleic acid, until form oily cream liquid can content；
（3）Pelleting：Capsule shell fluid and content solution are separately added in pellet press carries out pelleting, you can obtain soft capsule semi-finished product,
Setting shell thickness and content solution weight, shell thickness is 0.6-0.8mm, and content solution is 0.3-0.35g；
（4）It is dried：Soft capsule semi-finished product are put into into special drying in room and are dried process 12-24h, be dried in room
Room temperature be maintained at 20-25 DEG C；
（5）Polishing：Dried soft capsule semi-finished product are put into into capsule polisher and are processed by shot blasting 10-20min, remove flexible glue
The dust of capsule surface of semi-finished, improves soft capsule surface of semi-finished fineness；
（6）Lamp inspection：Soft capsule semi-finished product are carried out with lamp inspection process, the bad soft capsule semi-finished product of color and luster are removed；
（7）Select：Remove special-shaped ball, piller and big ball in soft capsule semi-finished product, you can obtain soft capsule finished product；
（8）Packaging：Soft capsule finished product packing to be got up be obtained finished product.
Above-mentioned a kind of ointment shape content composition soft capsule and preparation method thereof, wherein, described gelatin, water, glycerol and color
The part by weight of element is 100：100：40：0.1.
Above-mentioned a kind of ointment shape content composition soft capsule and preparation method thereof, wherein, described propolis, Semen Tritici aestivi germ oil,
Vitamin E, aminoacid are 32 with linoleic part by weight：60：4：1：3.
The beneficial effect of this programme：
A kind of ointment shape content composition soft capsule that the present invention is provided and preparation method thereof, wherein, a kind of ointment shape content flexible glue
Capsule includes softgel shell and content, and softgel shell is made of to add water, glycerol and pigment by major ingredient agent of gelatin；Content is to be with propolis
Major ingredient agent adds Semen Tritici aestivi germ oil, Vitamin E, aminoacid and linoleic acid to mix and makes, with supercritical CO 2 as extractant
Extracted, the solution for obtaining, finally carrying out pelleting using pellet press, then through drying, polishing, lamp inspection, select and bag
Dress is obtained finished product, and step is simple, it is easy to operate, easy to make, and the stability of soft capsule is high, it is easy to chew, soft capsule is strong
Degree is higher, and content can stable for extended periods of time, it is easy to stores, cost is relatively low, can more meet the demand of producer.
Specific embodiment
The specific embodiment of the present invention is described in further detail below by way of specific embodiment.
Embodiment one
A kind of ointment shape content composition soft capsule and preparation method thereof, wherein, a kind of ointment shape content composition soft capsule include softgel shell with
Content, its preparation method is as follows：
（1）It is prepared by capsule shell fluid：1. gelatin 100g, water 100g, glycerol 40g and pigment 0.1g are weighed；2. first water poured into glycerol
At the uniform velocity stir in pot, until after temperature is raised to 75 DEG C, adding gelatin to continue to stir 30min, obtain gelatin solution；3. add in gelatin solution
After entering pigment stirring 5min, you can obtain capsule shell fluid；
（2）It is prepared by content：1. the propolis 32g of selected high-quality, Semen Tritici aestivi germ oil 60g, Vitamin E 4g, amino acid/11 g and Asia are oily
Sour 3g；2. propolis is poured in extraction kettle, is extracted by extractant of supercritical CO 2, extracting pressure is 30MPa, temperature is
80 DEG C, supercritical CO 2 flow velocity be 18L/h, extraction time is 0.5h, obtains propolis supercritical carbon dioxide extraction thing；3. by Semen Tritici aestivi germ oil
Pour in pot and at the uniform velocity stir when temperature rises to 60 DEG C, add propolis supercritical carbon dioxide extraction thing to continue to stir addition dimension after 30min
Raw element E stirring 5min, and mixed liquor A can be obtained；4. aminoacid is sequentially added in mixed liquor A at the uniform velocity to stir with linoleic acid, until
Forming oily cream liquid can content；
（3）Pelleting：Capsule shell fluid and content solution are separately added in pellet press carries out pelleting, you can obtain soft capsule semi-finished product,
Setting shell thickness and content solution weight, shell thickness is 0.6mm, and content solution is 0.3g；
（4）It is dried：Soft capsule semi-finished product are put into into special drying in room and are dried process 12h, be dried in room
Room temperature is maintained at 20 DEG C；
（5）Polishing：Dried soft capsule semi-finished product are put into into capsule polisher and are processed by shot blasting 10min, remove soft capsule
The dust of surface of semi-finished, improves soft capsule surface of semi-finished fineness；
（6）Lamp inspection：Soft capsule semi-finished product are carried out with lamp inspection process, the bad soft capsule semi-finished product of color and luster are removed；
（7）Select：Remove special-shaped ball, piller and big ball in soft capsule semi-finished product, you can obtain soft capsule finished product；
（8）Packaging：Soft capsule finished product packing to be got up be obtained finished product.
Above-mentioned a kind of ointment shape content composition soft capsule and preparation method thereof, wherein, described gelatin, water, glycerol and color
The part by weight of element is 100：100：40：0.1.
Above-mentioned a kind of ointment shape content composition soft capsule and preparation method thereof, wherein, described propolis, Semen Tritici aestivi germ oil,
Vitamin E, aminoacid are 32 with linoleic part by weight：60：4：1：3.
Embodiment two
A kind of ointment shape content composition soft capsule and preparation method thereof, wherein, a kind of ointment shape content composition soft capsule include softgel shell with
Content, its preparation method is as follows：
（1）It is prepared by capsule shell fluid：1. gelatin 200g, water 200g, glycerol 80g and pigment 0.2g are weighed；2. first water poured into glycerol
At the uniform velocity stir in pot, until after temperature is raised to 80 DEG C, adding gelatin to continue to stir 40min, obtain gelatin solution；3. add in gelatin solution
After entering pigment stirring 8min, you can obtain capsule shell fluid；
（2）It is prepared by content：1. the propolis 64g of selected high-quality, Semen Tritici aestivi germ oil 120g, Vitamin E 8g, aminoacid 2g and Asia are oily
Sour 6g；2. propolis is poured in extraction kettle, is extracted by extractant of supercritical CO 2, extracting pressure is 40MPa, temperature is
85 DEG C, supercritical CO 2 flow velocity be 22L/h, extraction time is 1h, obtains propolis supercritical carbon dioxide extraction thing；3. Semen Tritici aestivi germ oil is fallen
Enter and at the uniform velocity stir in pot when temperature rises to 65 DEG C, add propolis supercritical carbon dioxide extraction thing to continue to stir addition dimension life after 40min
Plain E stirs 10min, and can obtain mixed liquor A；4. aminoacid is sequentially added in mixed liquor A at the uniform velocity to stir with linoleic acid, until shape
Can content into oily cream liquid；
（3）Pelleting：Capsule shell fluid and content solution are separately added in pellet press carries out pelleting, you can obtain soft capsule semi-finished product,
Setting shell thickness and content solution weight, shell thickness is 0.7mm, and content solution is 0.32g；
（4）It is dried：Soft capsule semi-finished product are put into into special drying in room and are dried process 18h, be dried in room
Room temperature is maintained at 22 DEG C；
（5）Polishing：Dried soft capsule semi-finished product are put into into capsule polisher and are processed by shot blasting 15min, remove soft capsule
The dust of surface of semi-finished, improves soft capsule surface of semi-finished fineness；
（6）Lamp inspection：Soft capsule semi-finished product are carried out with lamp inspection process, the bad soft capsule semi-finished product of color and luster are removed；
（7）Select：Remove special-shaped ball, piller and big ball in soft capsule semi-finished product, you can obtain soft capsule finished product；
（8）Packaging：Soft capsule finished product packing to be got up be obtained finished product.
Above-mentioned a kind of ointment shape content composition soft capsule and preparation method thereof, wherein, described gelatin, water, glycerol and color
The part by weight of element is 100：100：40：0.1.
Above-mentioned a kind of ointment shape content composition soft capsule and preparation method thereof, wherein, described propolis, Semen Tritici aestivi germ oil,
Vitamin E, aminoacid are 32 with linoleic part by weight：60：4：1：3.
Embodiment three
A kind of ointment shape content composition soft capsule and preparation method thereof, wherein, a kind of ointment shape content composition soft capsule include softgel shell with
Content, its preparation method is as follows：
（1）It is prepared by capsule shell fluid：1. gelatin 300g, water 300g, glycerol 120g and pigment 0.3g are weighed；2. first water poured into glycerol
At the uniform velocity stir in pot, until after temperature is raised to 90 DEG C, adding gelatin to continue to stir 50min, obtain gelatin solution；3. add in gelatin solution
After entering pigment stirring 10min, you can obtain capsule shell fluid；
（2）It is prepared by content：1. the propolis 96g of selected high-quality, Semen Tritici aestivi germ oil 180g, vitamin e1 2g, aminoacid 3g with it is sub-
Oleic acid 9g；2. propolis is poured in extraction kettle, is extracted by extractant of supercritical CO 2, extracting pressure is 45MPa, temperature
It is 25L/h for 90 DEG C, supercritical CO 2 flow velocity, extraction time is 1.5h, obtains propolis supercritical carbon dioxide extraction thing；3. by Fructus Tritici aestivi
Oil is poured in pot and at the uniform velocity stirred when temperature rises to 75 DEG C, adds propolis supercritical carbon dioxide extraction thing to continue to stir addition after 45min
Vitamin E stirs 15min, and can obtain mixed liquor A；4. aminoacid is sequentially added in mixed liquor A at the uniform velocity to stir with linoleic acid, directly
Can content to oily cream liquid is formed；
（3）Pelleting：Capsule shell fluid and content solution are separately added in pellet press carries out pelleting, you can obtain soft capsule semi-finished product,
Setting shell thickness and content solution weight, shell thickness is 0.8mm, and content solution is 0.35g；
（4）It is dried：Soft capsule semi-finished product are put into into special drying in room and are dried process 24h, be dried in room
Room temperature is maintained at 25 DEG C；
（5）Polishing：Dried soft capsule semi-finished product are put into into capsule polisher and are processed by shot blasting 20min, remove soft capsule
The dust of surface of semi-finished, improves soft capsule surface of semi-finished fineness；
（6）Lamp inspection：Soft capsule semi-finished product are carried out with lamp inspection process, the bad soft capsule semi-finished product of color and luster are removed；
（7）Select：Remove special-shaped ball, piller and big ball in soft capsule semi-finished product, you can obtain soft capsule finished product；
（8）Packaging：Soft capsule finished product packing to be got up be obtained finished product.
Above-mentioned a kind of ointment shape content composition soft capsule and preparation method thereof, wherein, described gelatin, water, glycerol and color
The part by weight of element is 100：100：40：0.1.
Above-mentioned a kind of ointment shape content composition soft capsule and preparation method thereof, wherein, described propolis, Semen Tritici aestivi germ oil,
Vitamin E, aminoacid are 32 with linoleic part by weight：60：4：1：3.
A kind of ointment shape content composition soft capsule that the present invention is provided and preparation method thereof, wherein, a kind of ointment shape content
Soft capsule includes softgel shell and content, and softgel shell is made of to add water, glycerol and pigment by major ingredient agent of gelatin；Content is with honeybee
Glue is that major ingredient agent adds the mixing of Semen Tritici aestivi germ oil, Vitamin E, aminoacid and linoleic acid to make, with supercritical CO 2 as extraction
Take agent to be extracted, the solution for obtaining, finally carrying out pelleting using pellet press, then through drying, polishing, lamp inspection, select
Finished product is obtained with packaging, step is simple, it is easy to operate, easy to make, the stability of soft capsule is high, it is easy to chew, flexible glue
Capsule intensity is higher, and content can stable for extended periods of time, it is easy to stores, cost is relatively low, can more meet the demand of producer.
The only present invention preferably specific embodiment, but protection scope of the present invention is not limited thereto, any to be familiar with
Those skilled in the art the invention discloses technical scope in, the change or replacement that can be readily occurred in all should be covered
Within the scope of the present invention.Therefore, protection scope of the present invention should be defined by the protection domain of claims.
Claims (3)
1. a kind of ointment shape content composition soft capsule and preparation method thereof, it is characterized by, a kind of ointment shape content composition soft capsule includes
Softgel shell and content, its preparation method is as follows：
（1）It is prepared by capsule shell fluid：1. gelatin 100-300g, water 100-300g, glycerol 40-120g and pigment 0.1-0.3g are weighed；②
First water is poured in pot with glycerol and is at the uniform velocity stirred, until after temperature is raised to 75-90 DEG C, add gelatin to continue to stir 30-50min,
Obtain gelatin solution；3. after pigment stirring 5-10min is added in gelatin solution, you can obtain capsule shell fluid；
（2）It is prepared by content：1. the propolis 32-96g of selected high-quality, Semen Tritici aestivi germ oil 60-180g, Vitamin E 4-12g, amino
Sour 1-3g and linoleic acid 3-9g；2. propolis is poured in extraction kettle, is extracted by extractant of supercritical CO 2, extracting pressure
For 30-45MPa, temperature be 80-90 DEG C, supercritical CO 2 flow velocity be 18～25L/h, extraction time is 0.5-1.5h, obtain propolis surpass
Critical CO2 extracts；3. Semen Tritici aestivi germ oil is poured in pot and is at the uniform velocity stirred when temperature rises to 60-75 DEG C, added propolis to surpass and face
CO2 extracts in boundary continue to stir addition Vitamin E stirring 5-15min after 30-45min, and can obtain mixed liquor A；4. to mixed liquor A
In sequentially add aminoacid and at the uniform velocity stir with linoleic acid, until form oily cream liquid can content；
（3）Pelleting：Capsule shell fluid and content solution are separately added in pellet press carries out pelleting, you can obtain soft capsule semi-finished product,
Setting shell thickness and content solution weight, shell thickness is 0.6-0.8mm, and content solution is 0.3-0.35g；
（4）It is dried：Soft capsule semi-finished product are put into into special drying in room and are dried process 12-24h, be dried in room
Room temperature be maintained at 20-25 DEG C；
（5）Polishing：Dried soft capsule semi-finished product are put into into capsule polisher and are processed by shot blasting 10-20min, remove flexible glue
The dust of capsule surface of semi-finished, improves soft capsule surface of semi-finished fineness；
（6）Lamp inspection：Soft capsule semi-finished product are carried out with lamp inspection process, the bad soft capsule semi-finished product of color and luster are removed；
（7）Select：Remove special-shaped ball, piller and big ball in soft capsule semi-finished product, you can obtain soft capsule finished product；
（8）Packaging：Soft capsule finished product packing to be got up be obtained finished product.
2. a kind of ointment shape content composition soft capsule as claimed in claim 1 and preparation method thereof, it is characterized by, described is bright
The part by weight of glue, water, glycerol and pigment is 100：100：40：0.1.
3. a kind of ointment shape content composition soft capsule as claimed in claim 1 and preparation method thereof, it is characterized by, described honeybee
Glue, Semen Tritici aestivi germ oil, Vitamin E, aminoacid are 32 with linoleic part by weight：60：4：1：3.
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|---|---|---|---|---|
| CN1258511A (en) * | 1999-11-18 | 2000-07-05 | 钱律余 | Supercritical multiple bee glue extracting process |
| CN101530178A (en) * | 2009-04-16 | 2009-09-16 | 江苏江大源生态生物科技有限公司 | Method for extracting propolis by simulative biological fluid bed supercritical CO2 fluid |
| CN102178821A (en) * | 2011-04-28 | 2011-09-14 | 柳正良 | Soft capsules for reducing blood sugar and preparation method thereof |
| CN102370667A (en) * | 2011-10-26 | 2012-03-14 | 江苏江大源生态生物科技有限公司 | Method for separating beeswax in propolis through supercritical CO2 |
| CN103637197A (en) * | 2013-12-03 | 2014-03-19 | 江苏江大源生态生物科技有限公司 | Propolis soft capsule and preparation method thereof |
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2016
- 2016-12-21 CN CN201611193514.9A patent/CN106581490A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1258511A (en) * | 1999-11-18 | 2000-07-05 | 钱律余 | Supercritical multiple bee glue extracting process |
| CN101530178A (en) * | 2009-04-16 | 2009-09-16 | 江苏江大源生态生物科技有限公司 | Method for extracting propolis by simulative biological fluid bed supercritical CO2 fluid |
| CN102178821A (en) * | 2011-04-28 | 2011-09-14 | 柳正良 | Soft capsules for reducing blood sugar and preparation method thereof |
| CN102370667A (en) * | 2011-10-26 | 2012-03-14 | 江苏江大源生态生物科技有限公司 | Method for separating beeswax in propolis through supercritical CO2 |
| CN103637197A (en) * | 2013-12-03 | 2014-03-19 | 江苏江大源生态生物科技有限公司 | Propolis soft capsule and preparation method thereof |
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Application publication date: 20170426 |