CN106581162A - Medicinal composition for treating nephrotic syndrome, medicine kit and use of medicinal composition - Google Patents
Medicinal composition for treating nephrotic syndrome, medicine kit and use of medicinal composition Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract description 67
- 206010029164 Nephrotic syndrome Diseases 0.000 title claims abstract description 12
- 239000009636 Huang Qi Substances 0.000 claims abstract description 21
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 13
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 13
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- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 13
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 18
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
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- A61K35/586—Turtles; Tortoises, e.g. terrapins
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/484—Glycyrrhiza (licorice)
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention provides a medicinal composition, a kit including the medicinal composition, and a use of the medicinal composition. The medicinal composition comprises a first traditional Chinese medicinal composition and a second traditional Chinese medicinal composition; the first traditional Chinese medicinal composition comprises Radix Stephaniae Tetrandrae, Radix Astragali, cassia twig, Poria cocos and licorice root according to a weight ratio of 10:(7-13):(7-13):(14-26):(1-20); and the second traditional Chinese medicinal composition comprises Radix Astragali, tortoiseshell, Chinese yam, coix seeds, corn silk, Eucommia ulmoides, hyacinth beans and millet sprouts according to a weight ratio of 5:(8-12):(4-6):(4-6):(8-12):(3-5):(4-6):(4-6). The medicinal composition, the medicine kit, medicines and healthcare foods have patient's urine protein index rapid reducing function, has a fast curative effect on the nephrotic syndrome, and has a very good restoration effect on the patient's body.
Description
Technical field
The present invention relates to technical field of Chinese medicine, more particularly to a kind of drug regimen for treating nephrotic syndrome
Thing, pharmaceutical kit and purposes.
Background technology
Nephrotic syndrome (NS) can be caused by Different types of etiopathogenises, with the increase of glomerular basement membrane permeability, show as a large amount of albumen
Urine, Hypoproteinemia, treating serious edema caused, hyperlipidemia one group of clinical syndrome.Chinese medicine ephrosis has some superiority.It
Nephridial tissue is repaired by diagnosis and treatment based on an overall analysis of the illness and the patient's condition, improves renal function, controlled ephrosis.But want the curative effect for having obtained, need one
The fixed time.Because several years even chronic disease of more than ten years, can not possibly overnight cure.So only adhering to medication
Can find out curative effect, one twice routine urianlysis can not describe the problem.Over the course for the treatment of, often can be because of flu, tired, mood
Fluctuation, it is improper diet etc. cause ephrosis repeatedly or recurrence.Therefore, a kind of effectively treatment of fast onset is urgently needed at present
The method of kidney trouble.
The content of the invention
It is therefore an object of the present invention to provide a kind of pharmaceutical composition for treating kidney trouble, pharmaceutical kit and
Purposes.
In one aspect of the invention, there is provided a kind of pharmaceutical composition for treating kidney trouble, described medicine
Composition is made up of the first Chinese medicine composition and the second Chinese medicine composition；The first described Chinese medicine composition by the root of fangji, the Radix Astragali,
Cassia twig, Poria cocos and liquorice are constituted, and its weight ratio is 10：7-13：7-13：14-26：1-20；The second described Chinese medicine composition
It is made up of the Radix Astragali, tortoiseshell, Chinese yam, coix seed, Li meter Xu, the bark of eucommia, French beans and rice sprout, its weight ratio is 5：8-12：4-6：4-
6：8-12：3-5：4-6：4-6.
In currently preferred aspect, the first described Chinese medicine composition, the root of fangji in the first described Chinese medicine composition,
The Radix Astragali, cassia twig, Poria cocos and liquorice are constituted, and its weight ratio is 10：7-13：7-13：14-26：2-4.
In currently preferred aspect, the first described Chinese medicine composition is by the root of fangji, the Radix Astragali, cassia twig, Poria cocos and liquorice institute
Composition, is by weight respectively 10,10,10,20 and 10 parts；The second described Chinese medicine composition is by the Radix Astragali, tortoiseshell, Chinese yam, the heart of a lotus seed
The seed of jog's tears, Li meter Xu, the bark of eucommia, French beans and rice sprout are constituted, and are by weight respectively 15,30,15,15,30,12,15 and 15 parts.
In currently preferred aspect, the first described Chinese medicine composition is by the root of fangji, the Radix Astragali, cassia twig, Poria cocos and liquorice institute
Composition, is by weight respectively 10,10,10,20 and 3 parts；The second described Chinese medicine composition is by the Radix Astragali, tortoiseshell, Chinese yam, Job's tears
Benevolence, Li meter Xu, the bark of eucommia, French beans and rice sprout are constituted, and are by weight respectively 15,24,23,12,24,9,12 and 12 parts.
In currently preferred aspect, the first described Chinese medicine composition is by the root of fangji, the Radix Astragali, cassia twig, Poria cocos and liquorice institute
Composition, is by weight respectively 10,12,8,15 and 3 parts；The second described Chinese medicine composition is by the Radix Astragali, tortoiseshell, Chinese yam, Job's tears
Benevolence, Li meter Xu, the bark of eucommia, French beans and rice sprout are constituted, and are by weight respectively 15,36,18,18,36,15,18 and 18 parts.
In currently preferred aspect, the first described Chinese medicine composition is by the root of fangji, the Radix Astragali, cassia twig, Poria cocos and liquorice institute
Composition, is by weight respectively 10,8,12,25 and 10 parts；The second described Chinese medicine composition is by the Radix Astragali, tortoiseshell, Chinese yam, Job's tears
Benevolence, Li meter Xu, the bark of eucommia, French beans and rice sprout are constituted, and are by weight respectively 15,30,15,15,30,12,15 and 15 parts.
In other aspects of the present invention, a kind of pharmaceutical kit is also disclosed, described pharmaceutical kit includes institute above
The pharmaceutical composition stated and necessary specification.
In other aspects of the present invention, the pharmaceutical composition for being previously described for treating kidney trouble is also disclosed in system
Purposes in the medicine of standby treatment nephrotic syndrome.
In other aspects of the present invention, the pharmaceutical composition for being previously described for treating kidney trouble is also disclosed in system
The purposes being ready for use in the health food of the patient body situation for improving nephrotic syndrome.
In other aspects of the present invention, the method to be treated using the pharmaceutical composition of the present invention is also described.Just
Phase Tetrandra and Poria Decoction, medication is easy in 3 months or so；Mid-term reduces to two plus siges and uses the fast good prescription of kidney instead when albumen, takes 5 days
Left and right can cure, if DeGrain, increase the consumption of the wherein Radix Astragali, but not more than 200 grams of consumption；Treatment end
Phase physical disorder all disappears, and discontinues medication.
There are the quick patient's Urine proteins that reduce to refer to for the pharmaceutical composition of the present invention, pharmaceutical kit, medicine and health food
Target function, has quick curative effect to nephrotic syndrome, and the recovery to patient body also has good effect.
Specific embodiment
The formula of the medicine of the present invention of embodiment 1 and fried
First Chinese medicine composition of the present invention is configured according to the preparation of table 1, prepares the present invention's according to the description of table 2
Second Chinese medicine composition.
Table 1：The formula table of the first Chinese medicine composition
Table 2：The formula table of the second Chinese medicine composition
Unless additionally illustrated, all of Chinese medicine is purchased from Tongrentang, is final medicine materical crude slice.Control group and test by more than
First Chinese medicine composition of group 1-4 is respectively placed in crock, adds cold water to being higher than 2-3 centimetre of medicinal material, soaks 1 hour afterwards,
Change boiling with soft fire 30 minutes after being boiled by fire, leach concoction.Plus cold water repeat to be boiled by fire, boiling with soft fire 30 minutes the step of, the
It is secondary to leach concoction.So repeat the 3rd time, obtain the concoction of the 3rd time.The concoction of three times is merged, the first Chinese medicine group is obtained
The concoction 500-600 milliliters of compound.It is fried that second Chinese medicine composition takes same method to carry out.
Embodiment 2：Animal experiment
According to《Practical Test doctor's magazine》,2011,03(2):Method described by 87-90 sets up the ephrosis synthesis of mouse
Model is levied, and the detection of mouse is carried out according to its examination criteria for describing.7 group of 6 week old nephrotic syndrome model mice is obtained,
6 per group, totally 42, it is denoted as A, B, C, D, E, F, G group.1 group of normal mouse, is designated as O groups, is not administered.By this seven
Group mouse is administered according to the description of table 3, and its twenty-four-hour urine protein content is weighed in and measured before and after drug delivery regimen
(HUPQ).Administration situation and urine albumen amount measurement result are displayed in table 3.Unless additionally illustrated, following mouse administration side
Formula is syringe and orally irrigates, and 2 times a day, respectively at 9 points in the morning and at 9 points in evening, each 0.6mL.Mouse is freely entering
Food and the mode drunk water are raised.
Unless additionally illustrated, in group O, A, it is not administered.In group B-C, gave within two weeks same
Medicine (the medicine soup that namely the first or second Chinese medicine composition is extracted according to embodiment 1).In group D-G, at first week
The first Chinese medicine composition is given, in second week the second Chinese medicine composition is given.
Table 3：The administrations and urine albumen amount of each group mouse：
In the data basis of table 3, the changes of weight percentage and twenty-four-hour urine of each group mouse have further been calculated
The change percentage of protein content, as shown in table 4.
Table 4：The changes of weight percentage of each group mouse and the change percentage of twenty-four-hour urine protein content
From in table 4, organizing the urine albumen amount of the mouse of B-G, to reduce amplitude very big, hence it is evident that higher than individually giving in first
The situation of drug composition and the second Chinese medicine composition.When the first Chinese medicine composition or the second Chinese medicine composition is individually given
(mouse organizes into groups B-C), mouse has a certain degree of body weight increase phenomenon, and has a certain degree of urine albumen amount to reduce.
In group D and G, the index of the above is substantially more excellent than B-C, and this shows that two kinds of prescriptions make under the situation being applied in combination
Obtain curative effect further to improve.In view of in group D and G, two kinds of prescriptions are not combined and are used, but replaced
Change, stopped in second week and give the first Chinese medicine composition and give the second Chinese medicine composition, this shows occur in group D and G
Cooperative effect.
In group E and F, the formula of Radix Glycyrrhizae decrement is studied.According to traditional theory of traditional Chinese medical science, Radix Glycyrrhizae be hundred medicines it
Monarch,, often as indispensable composition in most formulas, its component height also tends to extremely free for it.Doctor generally believes sweet
Grass is the booster action rather than decisive role for playing prescription.Inventors of the present invention have surprisingly found that, after decrement, mouse
The body weight increase rate and urine protein content of group E-F has gratifying change.This shows that the regulation of Radix Glycyrrhizae content contributes to obtaining more
Good therapeutic effect.
Embodiment 3：Human patientses are tested
Recruit 6 Patients With Nephrotic Symdromes, and have studied it and take the control group 1-2 of the present invention, test group 1-4
Changes of weight and urine protein content change before and after medicine, data above is embodied in table 5.Medicine above is according to embodiment
1 method carry out it is fried, for each person every day 7 points of morning and at 7 points in evening take medicine twice, each dosage for adult 250 milliliters, 15
Teenager below year is 150 milliliters.Medicining cycle is two weeks, for control group 1,2, a kind of its Chinese medicine composition is taken always
Extract.For test group 1-4, the first Chinese medicine composition extract is taken within first 7 days, take the second Chinese medicine composition within seven days afterwards and carry
Take thing.
The case of exception is that oneself medication of patient and the process of boiling medicine are completed by oneself, and are not completed in medical institutions.
Due to patient, oneself has school work in body, it is impossible to which the medical institutions that come take medicine sooner or later, so doctor is by important business kit：7
Pay the first Chinese medicine composition, 7 pair of second Chinese medicine composition, embodiment 1 in boiling medicine explanation and the present embodiment take explanation hand over
Its guardian Mr. heptan is given, is boiled medicine according to this explanation by its guardian and is supervised patient to take.
Table 5：Human patientses Test condition and result
Data more than can be seen, in the situation for taking the namely only single Chinese medicine composition of control group 1,2
Under, the body weight of patient does not have significant change, and urine albumen amount has declined, and final therapeutic effect is simultaneously not so good as people's will.
In the middle of the patient of medicine for taking test group 1-4, occur in that obvious body weight rises and Urine proteins index declines.
This shows that patients show obvious nutrition improvement and symptom and improve.22 years old third Mr. represents in interview is received, " in clothes
After with medicine to second week, feel to have a very good appetite, anasarca is reduced, urine amount is also improved." 58 years old Mr. Ding connecing
Represented by interview, " feeling that appetite is remarkably reinforced after second week, body is being clearly better, and legs and feet also have strength ".35 years old
Penta Ms represent, " lost the appetite during one's sickness in the past, anasarca.Since taking after second week, feel to have a very good appetite,
Oedema is also disappeared, and especially the oedema of eyelid is disappeared, and makes me very pleasantly surprised." 11 years old own child family Mr. ancient Chinese name for Venus
Represent, " since daughter makes a definite diagnosis illness, family circle extremely worries.Daughter's body weight is less than child of the same age, and let us is extremely worried.
Child has a meal more fragrant since medication, and we look at and extremely like ".
In addition, doctor also has found a phenomenon in investigation.The own child of 11 years old and penta Ms equal ten of 35 years old
Divide the taste for detesting Radix Glycyrrhizae.It is reported that, this is the phenomenon of generally existing in the women population of China.Doctor allows two patients to try
The first traditional Chinese medicine composition extract liquid of a little test group 1 is tasted, two Mies represent and are extremely difficult to swallow, feel extremely to dislike
The heart.But after the prescription for having used Radix Glycyrrhizae decrement, two Mies represent taste " still to receive ", therefore preferably complete
Into therapeutic test.Therefore, Radix Glycyrrhizae decrement prescription provided by the present invention has good for the vast crowd for being not suitable with Radix Glycyrrhizae taste
Good adaptability.
Claims (9)
1. a kind of pharmaceutical composition for treating kidney trouble, described pharmaceutical composition is by the first Chinese medicine composition and second
Chinese medicine composition is constituted；The first described Chinese medicine composition is made up of the root of fangji, the Radix Astragali, cassia twig, Poria cocos and liquorice, its weight
Than for 10：7-13：7-13：14-26：1-20；The second described Chinese medicine composition is by the Radix Astragali, tortoiseshell, Chinese yam, coix seed, chestnut rice
Palpus, the bark of eucommia, French beans and rice sprout are constituted, and its weight ratio is 5：8-12：4-6：4-6：8-12：3-5：4-6：4-6.
2. pharmaceutical composition according to claim 1, it is characterised in that described in the first described Chinese medicine composition
The root of fangji, the Radix Astragali, cassia twig, Poria cocos and liquorice are constituted in first Chinese medicine composition, and its weight ratio is 10：7-13：7-13：14-26：
2-4。
3. pharmaceutical composition according to claim 1, it is characterised in that the first described Chinese medicine composition is by the root of fangji, Huang
Stilbene, cassia twig, Poria cocos and liquorice are constituted, and are by weight respectively 10,10,10,20 and 10 parts；The second described Chinese medicine composition
Be made up of the Radix Astragali, tortoiseshell, Chinese yam, coix seed, Li meter Xu, the bark of eucommia, French beans and rice sprout, be by weight respectively 15,30,15,
15th, 30,12,15 and 15 parts.
4. pharmaceutical composition according to claim 1, it is characterised in that the first described Chinese medicine composition is by the root of fangji, Huang
Stilbene, cassia twig, Poria cocos and liquorice are constituted, and are by weight respectively 10,10,10,20 and 3 parts；The second described Chinese medicine composition
Be made up of the Radix Astragali, tortoiseshell, Chinese yam, coix seed, Li meter Xu, the bark of eucommia, French beans and rice sprout, be by weight respectively 15,24,23,
12nd, 24,9,12 and 12 parts.
5. pharmaceutical composition according to claim 1, it is characterised in that the first described Chinese medicine composition is by the root of fangji, Huang
Stilbene, cassia twig, Poria cocos and liquorice are constituted, and are by weight respectively 10,12,8,15 and 3 parts；The second described Chinese medicine composition by
The Radix Astragali, tortoiseshell, Chinese yam, coix seed, Li meter Xu, the bark of eucommia, French beans and rice sprout are constituted, be by weight respectively 15,36,18,18,
36th, 15,18 and 18 parts.
6. pharmaceutical composition according to claim 1, it is characterised in that the first described Chinese medicine composition is by the root of fangji, Huang
Stilbene, cassia twig, Poria cocos and liquorice are constituted, and are by weight respectively 10,8,12,25 and 10 parts；The second described Chinese medicine composition
Be made up of the Radix Astragali, tortoiseshell, Chinese yam, coix seed, Li meter Xu, the bark of eucommia, French beans and rice sprout, be by weight respectively 15,30,15,
15th, 30,12,15 and 15 parts.
7. a kind of pharmaceutical kit, it is characterised in that described pharmaceutical kit is included any one of claim 1-6
Pharmaceutical composition and necessary specification.
8. pharmaceutical composition any one of claim 1-6 prepare treatment nephrotic syndrome medicine in purposes.
9. pharmaceutical composition any one of claim 1-6 is preparing the patient body situation for improving nephrotic syndrome
Health food in purposes.
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| CN201710064361.6A CN106581162B (en) | 2017-02-04 | 2017-02-04 | Medicine box for treating nephrotic syndrome |
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| CN201710064361.6A CN106581162B (en) | 2017-02-04 | 2017-02-04 | Medicine box for treating nephrotic syndrome |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115554345A (en) * | 2022-05-09 | 2023-01-03 | 福建中医药大学附属第二人民医院（福建省第二人民医院） | A Chinese medicinal compound preparation for treating gout and hyperuricemia, and its preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547696A (en) * | 2015-01-04 | 2015-04-29 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for treating nephrotic syndrome of children and application of traditional Chinese medicine composition |
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2017
- 2017-02-04 CN CN201710064361.6A patent/CN106581162B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547696A (en) * | 2015-01-04 | 2015-04-29 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for treating nephrotic syndrome of children and application of traditional Chinese medicine composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115554345A (en) * | 2022-05-09 | 2023-01-03 | 福建中医药大学附属第二人民医院（福建省第二人民医院） | A Chinese medicinal compound preparation for treating gout and hyperuricemia, and its preparation method |
| CN115554345B (en) * | 2022-05-09 | 2024-01-26 | 福建中医药大学附属第二人民医院（福建省第二人民医院） | A Chinese medicinal compound preparation for treating gout and hyperuricemia, and its preparation method |
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| CN106581162B (en) | 2020-11-13 |
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