CN106580480A - Method for constructing cervical interbody fusion animal model of small-tail Han sheep and method for assessment of interbody fusion cages - Google Patents
Method for constructing cervical interbody fusion animal model of small-tail Han sheep and method for assessment of interbody fusion cages Download PDFInfo
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- CN106580480A CN106580480A CN201610945236.1A CN201610945236A CN106580480A CN 106580480 A CN106580480 A CN 106580480A CN 201610945236 A CN201610945236 A CN 201610945236A CN 106580480 A CN106580480 A CN 106580480A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/50—Prostheses not implantable in the body
- A61F2/76—Means for assembling, fitting or testing prostheses, e.g. for measuring or balancing, e.g. alignment means
- A61F2002/7615—Measuring means
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Abstract
The invention provides a method for constructing a cervical interbody fusion animal model of small-tail Han sheep and a method for assessment of interbody fusion cages. The method for constructing the cervical interbody fusion animal model of small-tail Han sheep includes: (1) subjecting small-tail Han sheep to weighing and anesthesia treatment; (2) fixing the small-tail Han sheep in a recumbent position, and performing skin preparation at the cervical vertebra position of the small-tail Han sheep; (3) incising skin and muscles at the position of skin preparation, and dilating soft tissues to expose vertebras; (4) using an oscillating saw for taking vertebral process between C4-C5 vertebras; (5) using a scalpel for cutting off an intervertebral disc between the C4-C5 vertebras, and using rongeur forceps for taking part of the intervertebral disc to form intervertebral disc coloboma and expose part of the lower surface of the C4 vertebra and part of the upper surface of the C5 vertebra; (6) using an abrasion drill for respectively perforating the exposed part of the lower surface of the C4 vertebra and part of the upper surface of the C5 vertebra to form two opposite grooves corresponding to the interbody fusion cages in size, so that the cervical interbody fusion animal model of small-tail Han sheep can be obtained. The cervical interbody fusion animal model of small-tail Han sheep can be used for effective assessment of the interbody fusion cages to further provide a reliable basis for screening and assessment of the interbody fusion cages.
Description
Technical field
The present invention relates to biomedicine field, specifically, the present invention relates to it is dynamic to build the fusion of Small-fat-tail sheep cervical intervertebral
The method of thing model and the method for evaluating Invasive lumbar fusion device.
Background technology
There are many Invasive lumbar fusion devices or implant for being used to treat cervical vertebra, lumbar vertebra etc. in the market, but for this
The quality of a little products and using without unified standard, and also no normalized animal model is used for the evaluation.
The content of the invention
It is contemplated that at least solving one of technical problem in correlation technique to a certain extent.For this purpose, the present invention
One purpose is to propose the method for structure Small-fat-tail sheep cervical intervertebral fusion animal model and for evaluating Invasive lumbar fusion device
Method, effectively Invasive lumbar fusion device can be evaluated using Small-fat-tail sheep cervical intervertebral fusion animal model, and then
Screening and evaluation for Invasive lumbar fusion device provides reliable basis.
According to an aspect of the present invention, the present invention proposes a kind of structure Small-fat-tail sheep cervical intervertebral fusion animal model
Method, including：
(1) Small-fat-tail sheep is weighed and anaesthetic treatment；
(2) Small-fat-tail sheep is fixed in supination type, and the cervical vertebra in the Small-fat-tail sheep carries out preserved skin process；
(3) skin and muscle at preserved skin process is cut, and retracts soft tissue, expose vertebral body；
(4) vertebra removed with goose saw between C4-C5 vertebral bodys is dashed forward；
(5) with the interpyramidal intervertebral disc of scalpel dialysis C4-C5, part of intervertebral disc is removed with rongeur, form intervertebral disc
Defect, and expose the portion lower surface of C4 vertebral bodys and the portion of upper surface of C5 vertebral bodys；And
(6) punched on the portion lower surface of the C4 vertebral bodys for exposing and the portion of upper surface of C5 vertebral bodys respectively with abrasive drilling, shape
Into two relative grooves correspondingly sized with Invasive lumbar fusion device, to obtain Small-fat-tail sheep cervical intervertebral fusion animal model.
Embodiments in accordance with the present invention, inventor find, by dynamic using the fusion of above-mentioned structure Small-fat-tail sheep cervical intervertebral
The method of thing model, the animal model for being obtained effectively can carry out test evaluation to various Invasive lumbar fusion devices, so as to vertebra
Between the performance of fusion device product evaluated, the research and development to Invasive lumbar fusion device product provide guidance.
In addition, the method for building Small-fat-tail sheep cervical intervertebral fusion animal model according to the above embodiment of the present invention may be used also
With with following additional technical characteristic：
Some embodiments of the invention, the body weight of the Small-fat-tail sheep is 40～50kg.
Some embodiments of the invention, the anaesthetic treatment include：To the Small-fat-tail sheep according to 0.1mL/kg's
Dosage carries out intramuscular injection land dormancy peaceful II；The Small-fat-tail sheep isoflurane is made using gas intubation of the internal diameter for 8.5mm.
Some embodiments of the invention, said method are further included：Before step (3) is carried out, at preserved skin
At reason, corresponding cervical vertebra is had an X-rayed, and excludes osseous tissue pathological changes, and according to X-ray line piece anticipation position to be implanted and treats intervertebral fusion
The specification of device.
Some embodiments of the invention, said method are further included：(7) soleplate and described is cleared up using nucleus pulposus clamp
Unnecessary osteomiosis in groove.
According to a further aspect in the invention, the present invention proposes a kind of method for evaluating Invasive lumbar fusion device, including：Root
Build according to foregoing method and obtain the Small-fat-tail sheep cervical intervertebral fusion animal model；To the Small-fat-tail sheep cervical vertebra vertebra
Between merge animal model and apply the Invasive lumbar fusion device.
Some embodiments of the invention, apply the intervertebral to Small-fat-tail sheep cervical intervertebral fusion animal model
Fusion device is carried out according to the following steps：
The Invasive lumbar fusion device is implanted into, and makes being stuck in two relative grooves of the Invasive lumbar fusion device；
Anterior plate fixation is placed on Invasive lumbar fusion device, and is fixed with screw, wound is closed in suture.
Some embodiments of the invention, the size of the Invasive lumbar fusion device is 1.5cm × 1.8cm × 0.6cm.
Some embodiments of the invention, the Invasive lumbar fusion device are implanted into, and make the card of the Invasive lumbar fusion device
In two relative grooves, while making the Invasive lumbar fusion device without departing from vertebral body plane.
Specific embodiment
Embodiments of the invention are described below in detail.The embodiments described below is exemplary, is only used for explaining this
It is bright, and be not considered as limiting the invention.Unreceipted particular technique or condition in embodiment, according to text in the art
Offer described technology or condition or carry out according to product description.Agents useful for same or the unreceipted production firm person of instrument,
For can pass through city available from conventional products.
According to an aspect of the present invention, the present invention proposes a kind of structure Small-fat-tail sheep cervical intervertebral fusion animal model
Method, including：(1) Small-fat-tail sheep is weighed and anaesthetic treatment；(2) Small-fat-tail sheep is fixed in supination type, and
Preserved skin process is carried out in the cervical vertebra of the Small-fat-tail sheep；(3) skin and muscle at preserved skin process is cut, and retracts soft group
Knit, expose vertebral body；(4) vertebra removed with goose saw between C4-C5 vertebral bodys is dashed forward；(5) with the interpyramidal intervertebrals of scalpel dialysis C4-C5
Disk, removes part of intervertebral disc with rongeur, forms intervertebral disc defect, and exposes the portion lower surface of C4 vertebral bodys and the portion of C5 vertebral bodys
Divide upper surface；And (6) are beaten on the portion lower surface of the C4 vertebral bodys for exposing and the portion of upper surface of C5 vertebral bodys respectively with abrasive drilling
Hole, forms two relative grooves correspondingly sized with Invasive lumbar fusion device, to obtain Small-fat-tail sheep cervical intervertebral fusion animal mould
Type.
Embodiments in accordance with the present invention, inventor find, by dynamic using the fusion of above-mentioned structure Small-fat-tail sheep cervical intervertebral
The method of thing model, the animal model for being obtained effectively can carry out test evaluation to various Invasive lumbar fusion devices, so as to vertebra
Between the performance of fusion device evaluated, the research and development to Invasive lumbar fusion device provide guidance.
According to a particular embodiment of the invention, the body weight of Small-fat-tail sheep is 40～50kg.
According to a particular embodiment of the invention, anaesthetic treatment is carried out after weigh Small-fat-tail sheep.Specifically, can basis
The body weight of Small-fat-tail sheep is given the anaesthetic of suitable dosage and is anaesthetized.According to a particular embodiment of the invention, anaesthetic treatment is concrete
Can carry out according to the following steps：Intramuscular injection land dormancy peaceful II is carried out according to the dosage of 0.1mL/kg to the Small-fat-tail sheep；Profit
The Small-fat-tail sheep isoflurane is made with the gas intubation that internal diameter is 8.5mm.Because the body weight of Small-fat-tail sheep it is larger, by above-mentioned
Secondary additional anesthesia can effectively maintain anaesthetic effect.In addition, inventor also has found, anaesthetized initially with the peaceful II of land dormancy,
Then inhalation anesthesia is carried out using isoflurane, anaesthetic effect can be effectively achieved, anesthesia timeliness reaches more than 1 hour.Wherein,
The dosage of isoflurane can be depending on the depth of anesthesia of Small-fat-tail sheep.
According to a particular embodiment of the invention, Small-fat-tail sheep is fixed in supination type, and in the cervical vertebra of Small-fat-tail sheep
Carry out preserved skin process.Preserved skin region is 10cm × 15cm, it is possible thereby to be easy to follow-up otch to expose C4 vertebral bodys and C5 vertebral bodys.
Inventor has found, if preserved skin region is too small, cannot obtain sufficiently large incision tract, and then cannot effectively expose C4 vertebras
Body and C5 vertebral bodys.After specific example of the invention, shaving cleaning skin, the position for shaving hair is disappeared with iodine tincture
Poison, then secondary sterilization, de- iodine are carried out with 75% ethanol.After the completion of preserved skin process, wound towel is spread in preserved skin position, expose otch
Position.
According to a particular embodiment of the invention, the skin and muscle at preserved skin process is cut, and retracts soft tissue, expose vertebra
Body.It is possible thereby to be easy to further process vertebral body.
According to a particular embodiment of the invention, the vertebra removed with goose saw between C4-C5 vertebral bodys is dashed forward.It is possible thereby to be easy to spill
C4-C5 vertebral bodys, are easy to subsequently process C4-C5 vertebral bodys.
According to a particular embodiment of the invention, with the interpyramidal intervertebral disc of scalpel dialysis C4-C5, portion is removed with rongeur
Divide intervertebral disc, form intervertebral disc defect, and expose the portion lower surface of C4 vertebral bodys and the portion of upper surface of C5 vertebral bodys.
According to a particular embodiment of the invention, further, with abrasive drilling the C4 vertebral bodys for exposing portion lower surface and C5
Punched on the portion of upper surface of vertebral body respectively, form two relative grooves correspondingly sized with Invasive lumbar fusion device, it is little to obtain
The cold sheep cervical intervertebral fusion animal model of tail.Specific example of the invention, the size of two relative grooves of formation with
The suitable size at Invasive lumbar fusion device two ends, and then the two ends of Invasive lumbar fusion device can be caused to snap in groove, so as to by C4 vertebral bodys with
C5 vertebral bodys are coupled together by Invasive lumbar fusion device.
According to a particular embodiment of the invention, the Small-fat-tail sheep cervical intervertebral that builds of above-described embodiment merges animal model
Method is still further comprised：Before step (3) is carried out, that is, before cutting the skin and muscle at preserved skin process, at preserved skin
At reason, corresponding cervical vertebra is had an X-rayed, and excludes osseous tissue pathological changes, and according to X-ray line piece anticipation position to be implanted and treats intervertebral fusion
The specification of device.It is possible thereby to be easy to find C4 vertebral bodys and C5 vertebral bodys, and then skin can be cut exactly and correct position is found
Put.Anticipation is carried out to the specification of Invasive lumbar fusion device simultaneously, and then the Invasive lumbar fusion device for preparing suitable dimension can be pre-designed, entered
And be easy to follow-up to the rapid implantation Invasive lumbar fusion device of animal model, raising implantation efficiency.
According to a particular embodiment of the invention, the Small-fat-tail sheep cervical intervertebral that builds of above-described embodiment merges animal model
Method is still further comprised：Unnecessary osteomiosis in soleplate and groove are cleared up using nucleus pulposus clamp.It is possible thereby to effectively carry out to groove
Cleaning, is easy to the implantation of follow-up Invasive lumbar fusion device, and the connection of Invasive lumbar fusion device and vertebral body.
According to a particular embodiment of the invention, formed on the portion lower surface of C4 vertebral bodys and the portion of upper surface of C5 vertebral bodys
The volume of two grooves be 1.5cm × 1.8cm × 0.6cm plus the volume between two grooves.And designed according to the volume
The size and shape of Invasive lumbar fusion device.The groove of the size can effectively cause the Invasive lumbar fusion device and C4 vertebral bodys and C5 of implantation
Vertebral body during subsequent growth with spinal fusion so that C4 vertebral bodys are fixedly connected with C5 vertebral bodys.If groove body
Product is excessive, and the infringement to C4 vertebral bodys and C5 vertebral bodys is excessive, is not easy to follow-up restoration ecosystem, and such as fruit volume is too small, is not easy to intervertebral
Fusion device is implanted into, if while if Invasive lumbar fusion device is meticulous, easily snapped off, while also do not reach being fixedly connected C4 vertebral bodys and C5
Vertebral body purpose.
According to a further aspect in the invention, the invention allows for a kind of method for evaluating Invasive lumbar fusion device.According to
The method for evaluating Invasive lumbar fusion device of the specific embodiment of the invention includes：Built according to foregoing method first and obtained
Small-fat-tail sheep cervical intervertebral merges animal model；And Invasive lumbar fusion device is applied to Small-fat-tail sheep cervical intervertebral fusion animal model.
Thus, by be implanted into Invasive lumbar fusion device between C4 vertebral bodys and C5 vertebral bodys connecing, during subsequent growth, C4 vertebral bodys and C5 vertebral bodys
Will with Invasive lumbar fusion device growth together with, and then cause be fixedly connected between C4 vertebral bodys and C5 vertebral bodys, between cannot activity.So as to
Reach alleviation and treat various vertebral body diseases.
According to a particular embodiment of the invention, intervertebral fusion utensil is applied to Small-fat-tail sheep cervical intervertebral fusion animal model
Body can be carried out according to the following steps：The Invasive lumbar fusion device is implanted into, and make the Invasive lumbar fusion device be stuck in two phases
To groove in；Anterior plate fixation is placed on Invasive lumbar fusion device, and is fixed with screw, wound is closed in suture.It is possible thereby to
Effectively Invasive lumbar fusion device is fixed between C4 vertebral bodys and C5 vertebral bodys, even and if activity also will not fall off.
According to a particular embodiment of the invention, the size of Invasive lumbar fusion device is 1.5cm × 1.8cm × 0.6cm.It is possible thereby to
Effectively by C4 vertebral bodys and C5 vertebral bodys in follow-up growth course together with Invasive lumbar fusion device fusion growth, so as to by C4 vertebras
Body is coupled together by Invasive lumbar fusion device with C5 vertebral bodys.Reach the purpose for the treatment of vertebral body disease.
According to a particular embodiment of the invention, Invasive lumbar fusion device is implanted into, and make the Invasive lumbar fusion device be stuck in two
In individual relative groove, while making the Invasive lumbar fusion device without departing from vertebral body plane.
Below with reference to specific embodiment, present invention is described, it should be noted that these embodiments are only described
Property, and the present invention is limited never in any form.
Embodiment
Build Small-fat-tail sheep cervical intervertebral fusion animal model and Invasive lumbar fusion device is evaluated using which
(1) animal
Small-fat-tail sheep；Body weight：45±5kg；Sex：Male and female are not limited.
(2) apparatus and material
The supporting apparatus of bone surgery set, product, Direct Digital flat panel X-ray imaging system (DR), general surgical procedures device
Tool, narcotics, first-aid medicine, disinfecting drug, operating room consumptive material etc..
(3) method
1. it is preoperative to prohibit feeding：The preoperative 24h of animal prohibits feeding and can't help water.
2. preoperative blank blood
5ml venous blood is gathered in jugular vein, for determining blood phase and serum biochemistry.
3. anaesthetize
Animal is weighed, and first intramuscular injection land is slept peaceful II (Hua Mu animal health-care products company limited of Jilin Province；2014.04,12),
Baoding is carried out with the dosage of 0.1ml/kg.
With the tracheal intubation of internal diameter 8.5mm, inhalation anesthetic is isoflurane, shows incoming call dose depending on depth of anesthesia.
4. preserved skin
Supination type, cervical region cropping, then lost hair or feathers with depilatory, normal saline cleaning, iodine tincture disinfection, the 75% de- iodine of ethanol.
Spread wound towel, exposure art portion.
5. row cervical vertebra perspective excludes osseous tissue pathological changes, according to X-ray line piece anticipation implantation position and weapon's standard.
6. operating procedure
(1) cutting operation area skin and muscle, appear the vertebral body of implanting；
(2) soft tissue is retracted, clears up the soft tissue at vertebral body position；
(3) vertebra for removing C4-C5 vertebral bodys with goose saw is dashed forward；
(4) with the interpyramidal intervertebral disc of scalpel dialysis C4-C5, part of intervertebral disc is removed with rongeur, form intervertebral disc
Defect；
(5) with abrasive drilling punching, defect and vertebral body, unnecessary osteomiosis in soleplate and hole are cleared up with nucleus pulposus clamp, formation is melted with intervertebral
The correspondingly sized defect of clutch.
(6) Invasive lumbar fusion device is implanted into, slightly firmly embedded, the dorsal part and vertebral body wound surface for making Invasive lumbar fusion device is put down in same
On face；
(7) anterior plate fixation is placed on Invasive lumbar fusion device, then is fixed with screw；
(8) wound is closed in conventional suture.
7. postoperative care
Postoperative fasting 12 hours, conventional 800,000 unit of intramuscular injection penicillin/only (2 times/day), and 80,000 unit of gentamycin/only
(2 times/day), totally 3 days；Postoperative daily observation animal 2 times, records its behavior and the mental status, observes the situation sewed up a wound simultaneously
Record.
8. detect
(1) blood phase and biochemical index
Take a blood sample, enter promoting the circulation of blood phase and biochemistry detection in the time point of setting.
(2) DR detections
Digitized video is obtained in normotopia, side position.
(3) Micro CT detections
Animal Anesthesia, dissection, the sampling of C4-C5 vertebral bodys, clear up muscle, remove anterior plate fixation, freeze in -20 DEG C, obtain
Micro CT images.
(4) pathology detection
Do hard pathological section, row pathological study.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
Example ", or the description of " some examples " etc. mean specific features with reference to the embodiment or example description, structure, material or spy
Point is contained at least one embodiment or example of the present invention.In this manual, to the schematic representation of above-mentioned term not
Identical embodiment or example must be directed to.And, the specific features of description, structure, material or feature can be arbitrary
Combined in individual or multiple embodiments or example in an appropriate manner.Additionally, in the case of not conflicting, the technology of this area
The feature of the different embodiments or example described in this specification and different embodiments or example can be combined by personnel
And combination.
Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment is example
Property, it is impossible to limitation of the present invention is interpreted as, one of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changes, replacing and modification.
Claims (9)
1. it is a kind of to build the method that Small-fat-tail sheep cervical intervertebral merges animal model, it is characterised in that to include：
(1) Small-fat-tail sheep is weighed and anaesthetic treatment；
(2) Small-fat-tail sheep is fixed in supination type, and the cervical vertebra in the Small-fat-tail sheep carries out preserved skin process；
(3) skin and muscle at preserved skin process is cut, and retracts soft tissue, expose vertebral body；
(4) vertebra removed with goose saw between C4-C5 vertebral bodys is dashed forward；
(5) with the interpyramidal intervertebral disc of scalpel dialysis C4-C5, part of intervertebral disc is removed with rongeur, form intervertebral disc defect,
And expose the portion lower surface of C4 vertebral bodys and the portion of upper surface of C5 vertebral bodys；And
(6) punched on the portion lower surface of the C4 vertebral bodys for exposing and the portion of upper surface of C5 vertebral bodys respectively with abrasive drilling, formed with
The correspondingly sized two relative grooves of Invasive lumbar fusion device, to obtain Small-fat-tail sheep cervical intervertebral fusion animal model.
2. method according to claim 1, it is characterised in that the body weight of the Small-fat-tail sheep is 40～50kg.
3. method according to claim 1, it is characterised in that the anaesthetic treatment includes：
Intramuscular injection land dormancy peaceful II is carried out according to the dosage of 0.1mL/kg to the Small-fat-tail sheep；
The Small-fat-tail sheep isoflurane is made using gas intubation of the internal diameter for 8.5mm.
4. method according to claim 1, it is characterised in that further include：
Before step (3) is carried out, corresponding cervical vertebra at preserved skin process is had an X-rayed, exclude osseous tissue pathological changes, and according to X-ray
Line piece anticipation position to be implanted and the specification for treating Invasive lumbar fusion device.
5. method according to claim 1, it is characterised in that further include：
(7) unnecessary osteomiosis in soleplate and the groove are cleared up using nucleus pulposus clamp.
6. a kind of method for evaluating Invasive lumbar fusion device, it is characterised in that include：
Method according to any one of Claims 1 to 5 builds and obtains the Small-fat-tail sheep cervical intervertebral fusion animal mould
Type；
The Invasive lumbar fusion device is applied to Small-fat-tail sheep cervical intervertebral fusion animal model.
7. method according to claim 6, it is characterised in that Small-fat-tail sheep cervical intervertebral fusion animal model is applied
Carried out according to the following steps with the Invasive lumbar fusion device：
The Invasive lumbar fusion device is implanted into, and makes being stuck in two relative grooves of the Invasive lumbar fusion device；
Anterior plate fixation is placed on Invasive lumbar fusion device, and is fixed with screw, wound is closed in suture.
8. method according to claim 6, it is characterised in that the size of the Invasive lumbar fusion device be 1.5cm × 1.8cm ×
0.6cm。
9. method according to claim 7, it is characterised in that the Invasive lumbar fusion device is implanted into, and makes the intervertebral
Fusion device is stuck in two relative grooves, while make the Invasive lumbar fusion device without departing from vertebral body plane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610945236.1A CN106580480A (en) | 2016-11-02 | 2016-11-02 | Method for constructing cervical interbody fusion animal model of small-tail Han sheep and method for assessment of interbody fusion cages |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610945236.1A CN106580480A (en) | 2016-11-02 | 2016-11-02 | Method for constructing cervical interbody fusion animal model of small-tail Han sheep and method for assessment of interbody fusion cages |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106580480A true CN106580480A (en) | 2017-04-26 |
Family
ID=58589581
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| CN201610945236.1A Withdrawn CN106580480A (en) | 2016-11-02 | 2016-11-02 | Method for constructing cervical interbody fusion animal model of small-tail Han sheep and method for assessment of interbody fusion cages |
Country Status (1)
| Country | Link |
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| CN (1) | CN106580480A (en) |
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2016
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