CN106580255A - Electric-control focusing ultrasonic detector used for photoacoustic imaging and electric-control focusing method thereof - Google Patents
Electric-control focusing ultrasonic detector used for photoacoustic imaging and electric-control focusing method thereof Download PDFInfo
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- CN106580255A CN106580255A CN201611140429.6A CN201611140429A CN106580255A CN 106580255 A CN106580255 A CN 106580255A CN 201611140429 A CN201611140429 A CN 201611140429A CN 106580255 A CN106580255 A CN 106580255A
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- control focusing
- dielectric layer
- electric control
- liquid
- photoacoustic imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
Abstract
The invention discloses an electric-control focusing ultrasonic detector used for photoacoustic imaging and an electric-control focusing method thereof. The detector comprises an annular ultrasonic transducer with an emitting/receiving surface used for generation/reception of ultrasonic waves, an electric-control focusing acoustic lens comprising polar conductive liquid (A) and non-polar insulating liquid (B) and a metal shell. A first electrode is separated from the liquid body through a hydrophobic and dielectric layer. A second electrode is in contact with the polar conductive liquid to generate an electrowetting effect. The metal shell is provided with a wire outlet. The annualar ultrasonic transducer and the electric-control focusing acoustic lens are coaxially arranged in the metal shell. The electric-control focusing ultrasonic detector used for photoacoustic imaging and the electric-control focusing method thereof have the following beneficial effects: by adoption of a special electric-control focusing acoustic lens structure, multi-scale photoacoustic imaging is realized; and aberration corrections of the special acoustic lens can achieve high resolution photoacoustic imaging with lateral resolution and depth resolution.
Description
Technical field
The present invention relates to the research field of photoacoustic imaging, more particularly to a kind of electric control focusing ultrasound spy for photoacoustic imaging
Survey device and its electric control focusing method.
Background technology
Ultrasonic diagnosises are that ultrasonic detecting technology is applied to into human body, by measurement understand physiology or organizational structure data and
Form, finds disease and makes a kind of diagnostic method of prompting.Ultrasonic diagnosises are a kind of noinvasive, painless, convenient and intuitively have
Effect detection methods, but its imaging method is relied on and the acoustic impedance of biological tissue, due to some tumor tissues acoustic impedance without
Obvious difference, this just limits the operation strategies of ultrasonic imaging technique and the contrast of its reconstructed picture is very low.
Photoacoustic imaging technology is a kind of Non-Destructive Testing medical imaging technology for developing in recent years, and it combines optical imagery and surpasses
The advantage of acoustic imaging, is just progressively becoming a new research direction of medical science Non-Destructive Testing.The imaging technique is with short-pulse laser
Used as driving source, and the ultrasonic signal for thus exciting is rebuild by corresponding image reconstruction algorithm and is organized as information carrier
The imaging method of internal structure and function information.The characteristics of technology combines optical imagery and acoustics imaging, it is possible to provide deep layer
The tissue tomographic map of tissue high-resolution and high-contrast, has wide in biomedical clinical diagnosis and imaging in vivo field
General application prospect.
At present, ultrasonic detector used in opto-acoustic microscopic imaging technology acoustics electric control focusing difficult to realize, it is difficult to obtain
The lateral resolution and depth resolution of get Geng Gao, it is impossible to realize multi-level imaging in the depth direction；In photoacoustic imaging technology
In used ultrasonic detector great majority be non-ring-shaped ultrasonic probe, it is difficult to ensure that incident illumination is coaxial with ultrasonic probe, finally
The resolution and detection sensitivity of opto-acoustic microscopic imaging system can be affected；More particularly, for the speckle in light acoustic microscopy
Light source, non-focusing ultrasonic probe is difficult to obtain higher signal to noise ratio, and detection sensitivity is not high.
The content of the invention
Present invention is primarily targeted at overcoming the shortcoming and deficiency of prior art, there is provided a kind of electricity for photoacoustic imaging
Control focusing ultrasonic detector and its electric control focusing method, the electric control focusing ultrasonic detector has preferably imaging effect, can electricity
The performance that control is focused can make opto-acoustic microscopic imaging system realize multi-level imaging in the depth direction, and acquisition is higher laterally to divide
Resolution and depth resolution.
In order to achieve the above object, the present invention is employed the following technical solutions：
The invention provides a kind of electric control focusing ultrasonic detector for photoacoustic imaging, including：
Metal shell,
Annular ultrasonic transducer, it has the transmitting/receiving surface of generation/reception ultrasound wave,
And electric control focusing acoustic lens, the electric control focusing acoustic lens include hydrophobic dielectric layer, polarity conductivity liquid (A),
Nonpolar iknsulating liquid (B), first and second electrode；The metal shell is provided with wire hole, described annular ultrasonic transducer
It is coaxially disposed inside metal shell with electric control focusing acoustic lens；
The hydrophobic dielectric layer is arranged on the lower end inside described metal shell,
The polarity conductivity liquid (A) and nonpolar iknsulating liquid (B) are mutually isolated, contact on meniscus, and have
There are different refractive indexs,
The first electrode, it is served as by described metal shell, by hydrophobic dielectric layer and polarity conductivity liquid (A) and
Nonpolar iknsulating liquid (B) separates；
Second electrode, it plays electrowetting effect effect to polarity conductivity liquid (A)；
The hydrophobic dielectric layer has electrowetting to nonpolar iknsulating liquid (B), this can electric wettability by electricity
Pressure changes in the case of putting between first electrode and second electrode so that the shape of meniscus depend on the voltage and
Change,
Wherein when no voltage is applied between the first and second electrodes, hydrophobic Jie to nonpolar iknsulating liquid (B)
The electrowetting of electric layer is substantially identical on the both sides that meniscus intersects with dielectric layer.
Used as preferred technical scheme, the annular ultrasonic transducer includes annular piezoelectric element, annular backing, matching layer
And annular acoustic board, described annular piezoelectric element, annular backing, matching layer and annular acoustic board arranged coaxial.
Used as preferred technical scheme, described annular piezoelectric element is circular ring structure, and dominant frequency is 20～50MHz, bandwidth
For 85%～115%, sensitivity is -35～-60dB；
The material of described annular acoustic board is glass fiber material, and thickness is 1～5mm, and internal diameter is tied for the annulus of 3mm
Structure, surface is smooth；
Described matching layer is epoxy resin marine glue, and using spraying method the transmitting/reception of PVDF piezoelectric membranes is coated in
The surface of ultrasound wave, matching layer thickness is 1～3 μm.
Used as preferred technical scheme, described polarity conductivity liquid (A) is colourless with nonpolar iknsulating liquid (B)
Prescribed liquid, light transmittance is not less than 95%, and the equal density of the two.
Used as preferred technical scheme, the hydrophobic dielectric layer includes convex optical glass, class vertebral body optical glass and dredges
Water dielectric layer pipe, the convex optical glass, class vertebral body optical glass and hydrophobic dielectric layer pipe are bonded in successively one；Institute
State class vertebral body optical glass top and be provided with concave arc type groove.
Used as preferred technical scheme, described annular ultrasonic transducer is coaxially disposed in convex optical glass top；Institute
The second electrode stated is served as by becket, and becket is coaxially disposed in convex optical glass bottom；The electricity of electric control focusing acoustic lens
Source line is made up of the first and second described electrodes, is drawn from the wire hole of metal shell.
As preferred technical scheme, described convex optical glass, class vertebral body optical glass and hydrophobic dielectric layer pipe
Using polystyrene material, its light transmittance is not less than 92% not less than 95%, entrant sound rate.
Used as preferred technical scheme, described nonpolar iknsulating liquid (B) is located at the top of class vertebral body optical glass, institute
Polarity conductivity liquid (A) is stated positioned at nonpolar iknsulating liquid (B) top, the two fills the inner chamber of whole acoustic lens, finally fills
Interior intracavity bubble-free.
Present invention also offers a kind of electric control focusing method of the electric control focusing ultrasonic detector for photoacoustic imaging, including
Following step：
(1) described second electrode becket is loaded onto in hydrophobic dielectric layer；Respectively by polarity conductivity liquid (A) and non-pole
Property the whole hydrophobic dielectric layer of iknsulating liquid (B) injection inner chamber, the interior intracavity bubble-free for filling, finally to whole hydrophobic dielectric layer
Sealing, wherein polarity conductivity liquid (A) is immiscible with nonpolar iknsulating liquid (B), contacts on meniscus, and has
Different refractive indexs；
(2) hydrophobic dielectric layer, it is installed in the interior bottom of described metal shell, then sets annular ultrasonic transducer
Be placed in hydrophobic dielectric layer top, metal shell as first electrode, becket as second electrode, respectively from outside described metal
Shell wire hole is drawn；
(3) according to the actual requirements, described additional regulation and control voltage is controlled to change the shape of meniscus, it is final to change ultrasound
Sound Jiao's length of detector, focused spot diameter, depth of focus, wherein the meniscus between 100 and 140 degree with hydrophobic dielectric layer
Contact angle.
Used as preferred technical scheme, with the increase of additional modulation voltage, electricity moisten effect is strengthened, the deformation of meniscus
Increase, the radius of curvature for causing meniscus reduces, i.e. acoustic lens are higher to the focusing power of ultrasound, and focused ultrasound field focal length subtracts
Little, focus acoustic pressure increase, focus acoustic energy strengthens, and acoustic beam attenuates, and acoustic blur energy is more assembled.
The present invention compared with prior art, has the advantage that and beneficial effect：
(1) present invention can realize the optoacoustic confocal excitation detecting structure of photoacoustic imaging system, be visited by the unit ultrasound
The electric control focusing of device is surveyed, optical focus is only scanned on sound field Jiao's waist of ultrasonic detector, it is burnt by automatically controlled mobile acoustics
Point, realizes high within the specific limits, uniform image resolution ratio and contrast, improves detectivity.
(2) present invention by electric control focusing, can adjust the size of the burnt long and sound depth of focus of sound of ultrasonic detector, final energy
The multi-level Depth Imaging of photoacoustic imaging system is enough realized, by aberration correction to being enough to obtain with lateral resolution and depth
The degree of the high-resolution imaging of degree resolution.
(3) for speckle light source, by the sound focused spot diameter of automatically controlled regulation ultrasonic detector, dissipating for LASER Light Source can be made
Speckle it is maximized fall in sound field focal spot, allow the ultrasonic probe receive more photoacoustic signals, and then photoacoustic imaging system
Signal to noise ratio can be greatly improved.
(4) the invention provides a kind of electric control focusing ultrasonic detector for photoacoustic imaging, simple structure, manipulation side
Just, can preferably coordinate ultrasound/photoacoustic imaging system, be conducive to promoting and apply.
Description of the drawings
Fig. 1 is the cross-sectional view of the electric control focusing ultrasonic detector that the embodiment of the present invention 1 is used for photoacoustic imaging；
Fig. 2 is the axonometric chart of the electric control focusing ultrasonic detector that the embodiment of the present invention 1 is used for photoacoustic imaging；
Fig. 3 be for photoacoustic imaging electric control focusing ultrasonic detector with additional modulation voltage change in the case of, its
The curvature of meniscus and the focus variations schematic diagram of sound field.
Drawing reference numeral explanation：1st, metal shell；1-1, wire hole；2nd, annular ultrasonic transducer；2-1, light well；3rd, convex
Optical glass；4th, becket；5th, hydrophobic dielectric layer pipe；6th, class vertebral body optical glass；6-1, arc groove；7th, ring-shaped ultrasonic is changed
The holding wire of energy device；8th, the coaxial wire of acoustic lens；9th, first electrode；10th, second electrode；11st, the inner chamber of acoustic lens；12、
Natural sound field；13rd, the first meniscus；14th, the second meniscus；15th, the first acoustic field focus；16th, the second acoustic field focus.
Specific embodiment
With reference to embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention are not limited
In this.
Embodiment 1
As illustrated in fig. 1 and 2, a kind of electric control focusing ultrasonic detector for photoacoustic imaging, including metal shell 1, outlet
Hole 1-1, annular ultrasonic transducer 2, light well 2-1, convex optical glass 3, becket 4, hydrophobic dielectric layer pipe 5, class vertebral body
Optical glass 6, concave arc type groove 6-1, the coaxial wire 8 of the holding wire 7, acoustic lens of annular ultrasonic transducer, first electrode 9,
The inner chamber 11 of second electrode 10, acoustic lens, polarity conductivity liquid (A) and nonpolar iknsulating liquid (B).
A kind of described electric control focusing ultrasonic detector for photoacoustic imaging is made, embodiment 1 requires that ring-shaped ultrasonic is changed
Energy device 2 includes annular piezoelectric element, annular backing, matching layer and annular acoustic board.
The piezoelectric for requiring piezoelectric element adopts PVDF piezoelectric membranes, and thickness is 9 μm, using external diameter 8mm, internal diameter 3mm
Circular ring structure, dominant frequency is 50MHz, and with a width of 115%, sensitivity is -35dB.
The material for requiring annular acoustic board is glass fiber material, and thickness is 3mm, internal diameter for 3mm circular ring structure, surface
Smooth, sound insulation/acoustically effective is fine.
The material for requiring annular backing is formed for epoxy resin with alumina powder proportioning, its quality proportioning ratio 3:1, its
Thickness is 2mm, and external diameter is the circular ring structure of 3mm, and surface is smooth.
Requirement matching layer is epoxy resin marine glue, and its acoustic impedance relatively, is coated in water using spraying method
The surface of the transmitting of PVDF piezoelectric membranes/reception ultrasound wave, matching layer thickness is 2 μm.
The material of metal shell 1 is stainless steel material, and first electrode 9 and second electrode 10 are using a coaxial cable knot
Structure, wherein, used as the core of coaxial cable 8, used as the positive source of acoustic lens, first electrode 9 is saturating as sound for second electrode 10
The power cathode of mirror.
Polarity conductivity liquid (A) is NaCl saline solution, and nonpolar iknsulating liquid (B) is alkane liquid, and the two is all colourless
Transparency liquid, its light transmittance is equal to 95%, and the density of the two is equal to 1.45 × 103 ㎏/m3.
Annular ultrasonic transducer 2 is coaxially disposed in the top of convex optical glass 3；Described second electrode 10 is by becket 4
Serve as, becket 4 is coaxially disposed in the bottom of convex optical glass 3；The power line of electric control focusing acoustic lens is electric by described first
Pole 9 and second electrode 10 are constituted, and are drawn from the wire hole 1-1 of metal shell 1.
Becket 4 adopts stainless steel material, the boss equal diameters of its internal diameter and convex optical glass 3, the top of becket 4
Bonding wire, is then drawn second electrode 10 by the lead aperture of convex optical glass 3, and first electrode 9 is welded and metal shell 1
Inwall on.
Convex optical glass 3, class vertebral body optical glass 6 and hydrophobic dielectric layer pipe 5 adopt PS (polystyrene) material, its
Light transmittance is equal to 95%, entrant sound rate and is equal to 92%.
The arc radius of concave arc type groove 6-1 of class vertebral body optical glass 6 are 50mm, and groove depth is 0.5mm.
Nonpolar iknsulating liquid (B) is located at the top of class vertebral body optical glass 6, and polarity conductivity liquid (A) is located at nonpolar
Iknsulating liquid (B) top, the two fills the inner chamber 11 of whole acoustic lens, bubble-free in the inner chamber 11 for finally filling.
Embodiment 2
With a kind of electric control focusing ultrasonic detector for photoacoustic imaging of example 1, test in photoacoustic imaging system
Its electric control focusing performance, it can be deduced that the schematic diagram of Fig. 3.
Load onto in hydrophobic dielectric layer first on described becket 4, then respectively by polarity conductivity liquid (A) and non-pole
Property the whole hydrophobic dielectric layer of iknsulating liquid (B) injection inner chamber 11, bubble-free in the inner chamber 11 for filling, finally to whole hydrophobic Jie
Electric layer is sealed, and wherein polarity conductivity liquid (A) is immiscible with nonpolar iknsulating liquid (B), is contacted on meniscus, and
With different refractive indexs.Hydrophobic dielectric layer, it is installed in the interior bottom of described metal shell 1, then by ring-shaped ultrasonic
Transducer 2 is arranged at convex optical glass 3, and, used as first electrode 9, becket 4 is used as second electrode 10, difference for metal shell 1
Draw from the wire hole 1-1 of described metal shell 1.The electric control focusing ultrasonic detector is finally accessed the light put up
In acoustic imaging system.
Test performance is as follows：Described additional modulation voltage V is 100V to 130V, when additional modulation voltage is 100V,
The radius of curvature of meniscus is the second meniscus 14, and now area for sound,focal is the second acoustic field focus 16, then as additional modulation electricity
The increase of pressure V, the radius of curvature of meniscus is gradually reduced, and ultrasonic transducer most starts possess natural sound field 12, i.e. acoustic lens pair
The focusing power of ultrasound is higher, and focused ultrasound field focal length reduces, and focus acoustic pressure increase, focus acoustic energy strengthens, and acoustic beam attenuates, sound
Speckle energy is more assembled, and finally when additional modulation voltage V is 130V, the radius of curvature of meniscus is changed into the first meniscus 13,
Area for sound,focal now is the first focus of sound field 15.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention not by above-described embodiment
Limit, other any spirit without departing from the present invention and the change, modification, replacement made under principle, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. a kind of electric control focusing ultrasonic detector for photoacoustic imaging, including metal shell, it is characterised in that also include：
Annular ultrasonic transducer, it has the transmitting/receiving surface of generation/reception ultrasound wave,
And electric control focusing acoustic lens, the electric control focusing acoustic lens include hydrophobic dielectric layer, polarity conductivity liquid (A), non-pole
Property iknsulating liquid (B), first and second electrode；The metal shell is provided with wire hole, described annular ultrasonic transducer and electricity
Control focusing acoustic lens are coaxially disposed inside metal shell；
The hydrophobic dielectric layer is arranged on the lower end inside described metal shell,
The polarity conductivity liquid (A) and nonpolar iknsulating liquid (B) are mutually isolated, contact on meniscus, and with not
Same refractive index,
The first electrode, it is served as by described metal shell, by hydrophobic dielectric layer and polarity conductivity liquid (A) and non-pole
Property iknsulating liquid (B) separate；
Second electrode, it plays electrowetting effect effect to polarity conductivity liquid (A)；
The hydrophobic dielectric layer has electrowetting to nonpolar iknsulating liquid (B), this can electric wettability voltage is being applied
Change in the case of being added between first electrode and second electrode, so that the shape of meniscus depends on the voltage and becomes
Change,
Wherein when no voltage is applied between the first and second electrodes, the hydrophobic dielectric layer to nonpolar iknsulating liquid (B)
Electrowetting be substantially identical on the both sides that meniscus intersects with dielectric layer.
2. the electric control focusing ultrasonic detector of photoacoustic imaging is used for according to claim 1, it is characterised in that the annular is super
Sonic transducer includes annular piezoelectric element, annular backing, matching layer and annular acoustic board, described annular piezoelectric element, annular
Backing, matching layer and annular acoustic board arranged coaxial.
3. the electric control focusing ultrasonic detector for photoacoustic imaging according to claim 1 or claim 2, it is characterised in that described
Annular piezoelectric element is circular ring structure, and dominant frequency is 20～50MHz, and with a width of 85%～115%, sensitivity is -35～-60dB；
The material of described annular acoustic board be glass fiber material, thickness be 1～5mm, internal diameter for 3mm circular ring structure, table
Face is smooth；
Described matching layer is epoxy resin marine glue, and using spraying method the transmitting/reception ultrasound of PVDF piezoelectric membranes is coated in
The surface of ripple, matching layer thickness is 1～3 μm.
4. the electric control focusing ultrasonic detector of photoacoustic imaging is used for according to claim 1, it is characterised in that described polarity
Conducting liquid (A) is colourless transparent liquid with nonpolar iknsulating liquid (B), and light transmittance is not less than 95%, and the density of the two
It is equal.
5. the electric control focusing ultrasonic detector of photoacoustic imaging is used for according to claim 1, it is characterised in that hydrophobic Jie
Electric layer includes convex optical glass, class vertebral body optical glass and hydrophobic dielectric layer pipe, the convex optical glass, class vertebral body light
Learn eyeglass and hydrophobic dielectric layer pipe is bonded in successively one；The class vertebral body optical glass top is provided with concave arc type groove.
6. the electric control focusing ultrasonic detector of photoacoustic imaging is used for according to claim 5, it is characterised in that described annular
Ultrasonic transducer is coaxially disposed in convex optical glass top；Described second electrode is served as by becket, and becket coaxially sets
It is placed in convex optical glass bottom；The power line of electric control focusing acoustic lens is made up of the first and second described electrodes, from metal
The wire hole of shell is drawn.
7. the electric control focusing ultrasonic detector of photoacoustic imaging is used for according to claim 5, it is characterised in that described convex
Optical glass, class vertebral body optical glass and hydrophobic dielectric layer pipe adopt polystyrene material, its light transmittance not less than 95%, thoroughly
Sound rate is not less than 92%.
8. the electric control focusing ultrasonic detector of photoacoustic imaging is used for according to claim 5, it is characterised in that described non-pole
Property iknsulating liquid (B) be located at class vertebral body optical glass top, the polarity conductivity liquid (A) be located at nonpolar iknsulating liquid
(B) top, the two fills the inner chamber of whole acoustic lens, the interior intracavity bubble-free for finally filling.
9. the electric control focusing side of the electric control focusing ultrasonic detector of photoacoustic imaging is used for according to any one of claim 1-8
Method, it is characterised in that comprise the steps：
(1) described second electrode becket is loaded onto in hydrophobic dielectric layer；It is respectively that polarity conductivity liquid (A) is exhausted with nonpolar
The inner chamber of the whole hydrophobic dielectric layer of edge liquid (B) injection, the interior intracavity bubble-free for filling is finally close to whole hydrophobic dielectric layer
Envelope, wherein polarity conductivity liquid (A) is immiscible with nonpolar iknsulating liquid (B), contacts on meniscus, and with not
Same refractive index；
(2) hydrophobic dielectric layer, it is installed in the interior bottom of described metal shell, is then arranged at annular ultrasonic transducer
Hydrophobic dielectric layer top, metal shell goes out respectively as second electrode as first electrode, becket from described metal shell
String holes is drawn；
(3) according to the actual requirements, described additional regulation and control voltage is controlled to change the shape of meniscus, finally change supersonic sounding
Sound Jiao's length of device, focused spot diameter, depth of focus, wherein the meniscus has the contact with hydrophobic dielectric layer between 100 and 140 degree
Angle.
10. electric control focusing method according to claim 9, it is characterised in that with the increase of additional modulation voltage, electricity is wet
Profit effect is strengthened, and the deformation increase of meniscus, the radius of curvature for causing meniscus reduces, i.e. focusing power of the acoustic lens to ultrasound
Higher, focused ultrasound field focal length reduces, and focus acoustic pressure increase, focus acoustic energy strengthens, and acoustic beam attenuates, acoustic blur energy more addition polymerization
Collection.
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Application publication date: 20170426 |