CN106563016A - New uses of semen persicae - Google Patents
New uses of semen persicae Download PDFInfo
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- CN106563016A CN106563016A CN201510652231.5A CN201510652231A CN106563016A CN 106563016 A CN106563016 A CN 106563016A CN 201510652231 A CN201510652231 A CN 201510652231A CN 106563016 A CN106563016 A CN 106563016A
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- semen persicae
- parched
- persicae
- semen
- decoction liquor
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Abstract
The present invention discloses new uses of semen persicae, particularly uses of semen persicae or boiling-water-soaked semen persicae or fried semen persicae in tumor angiogenesis inhibition drugs, wherein an effective dose of the semen persicae or boiling-water-soaked semen persicae or fried semen persicae is adopted as an active component and is added with a pharmaceutically acceptable auxiliary material according to a conventional pharmacy method to prepare the agent, ie., the tumor angiogenesis inhibition drug. According to the present invention, the semen persicae or boiling-water-soaked semen persicae or fried semen persicae is applied in the tumor angiogenesis inhibition, such that the tumor growth can be effectively inhibited, the good medicinal value is provided, and the new selection is provided for the clinic.
Description
Technical field
The invention belongs to field of medicaments, and in particular to the new application of Semen Persicae, especially Semen Persicae orSemen Persicae or Semen Persicae (parched) are preparing suppression
Purposes in the medicine of tumor angiogenesis processed.
Background technology
Angiogenesis (angiogenesis) are to germinate to generate the process of neovascularity from existing blood vessel.This process is thin with blood vessel endothelium
Born of the same parents' migration is related to propagation.Embryo development procedure is accompanied by angiogenesis.But except wound healing, female menstrual period and some pathology
Outward, seldom there are angiogenesis to process (such as cancer) in adult.
Growth, transfer or even prognosis of the angiogenesis to malignant entity tumor suffer from extremely important meaning.Angiogenesis are to dislike
Property entity tumor break through after basement membrane of epithelium necessary to further growth.In tumor, the new blood vessel for being formed has its own uniqueness
Construction featuress, it is imperfect to show as tube wall, without smooth muscle elements, is only made up of the basement membrane of the endotheliocyte and lamellar that have hole.It is many
Number scholar thinks that the construction featuress of new vesselses are possibly realized malignant tumor tissue generation metastasis.Therefore, malignant entity
In tumor, new vesselses is considered as quantitatively a kind of important independent prognostic marker.
Semen Persicae is rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch.
Dry mature seed.Nature and flavor bitter, sweet, flat.GUIXIN, liver, large intestine channel.With blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma
Effect.For amenorrhea dysmenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen, lung abscess acute appendicitis, injury from falling down, dry constipation of intestines, cough and asthma.Usage and dosage
5～10g.The processed product of Semen Persicae have Semen Persicae,Three kinds of Semen Persicae or Semen Persicae (parched).
Although also it has been reported which has antitumor action, not finding which has the effect for suppressing tumor angiogenesis.
The content of the invention
First technical problem solved by the invention is to provide a kind of new medicine use of Semen Persicae.
The new medicine use of Semen Persicae provided by the present invention be Semen Persicae orSemen Persicae or Semen Persicae (parched) are preparing suppression tumor neogenetic blood vessels life
Into medicine in new application.
The medicine be with the Semen Persicae of effective dose orSemen Persicae or Semen Persicae (parched) are active component, according to pharmacy conventional method, are added
The medicament that adjuvant pharmaceutically is prepared from.Oral formulations or injection can specifically be made, by oral, intramuscular injection,
The mode such as vein input or lumbar injection is administered.
Second technical problem solved by the invention is to provide a kind of pharmaceutical composition for suppressing tumor angiogenesis, especially
Main active be Semen Persicae orSemen Persicae or Semen Persicae (parched), according to the medicament that pharmacy conventional method is prepared from.Can be with during preparation
Customary adjuvant pharmaceutically is added to prepare.Active component can be with the effect with addition of other antineoplastic agents increase Synergistics.Medicament
Per preparation unit contain Semen Persicae or5～30 grams of Semen Persicae or Semen Persicae (parched).
The customary adjuvant include the conventional diluent of pharmaceutical field, excipient, filler, binding agent, wetting agent, disintegrating agent,
Absorption enhancer, surfactant, absorption carrier, lubricant etc..
With Semen Persicae orSemen Persicae or Semen Persicae (parched) are that the medicine of suppression tumor angiogenesis prepared by active component can be made orally
The various ways such as agent, injection.The medicine of above-mentioned various dosage forms can be prepared according to the conventional method of pharmaceutical field.
3rd technical problem solved by the invention is to provide the preparation of the pharmaceutical composition of above-mentioned suppression tumor angiogenesis
Method.Including：
Method one：By Semen Persicae orSemen Persicae or Semen Persicae (parched) are ground into fine powder, mixing powder；Or
Method two：By Semen Persicae orSemen Persicae or Semen Persicae (parched) are ground into fine powder, encapsulated capsule；Or
Method three：By Semen Persicae orSemen Persicae or Semen Persicae (parched) are ground into fine powder, and tabletting is piece agent；Or
Method four：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, decoction liquor is filtered to obtain；Or
Method five：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, decoction liquor is filtered to obtain, decoction liquor is dried；Or
Method six：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, concentrated extracting solution makes granule, granule；
Or
Method seven：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, concentrated extracting solution makes granule, encapsulated
Capsule；Or
Method eight：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, concentrated extracting solution makes granule, and tabletting is i.e. in blocks
Agent；Or
Method nine：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, water decoction is made, or adds customary adjuvant to make mouth
Take liquid, syrup, mixture.
One of preferred method：Comprise the steps：
A, Semen Persicae orSemen Persicae or Semen Persicae (parched) are added water to cook, and filter to obtain decoction liquor；
B, it is dried decoction liquor and obtains final product.
Further, step B is dried decoction liquor and is less than 5% to water content.
One of preferred method：Comprise the steps：
A, Semen Persicae orSemen Persicae or Semen Persicae (parched) are added water to cook, and filter to obtain decoction liquor；
B, decoction liquor add customary adjuvant to be pharmaceutically prepared according to pharmacy conventional method.
Can specifically make oral formulations or injection, the customary adjuvant that can be added include the conventional diluent of pharmaceutical field,
Excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant
Deng.
To sum up, the present invention adopt Semen Persicae orSemen Persicae or Semen Persicae (parched) suppress tumor angiogenesis effect notable, are clinical suppression
Tumor angiogenesis and treatment tumor provide a kind of brand-new selection.
Description of the drawings
The juvenile fish light microscopic figure that Fig. 1 Semen Persicaes are intervened.
The juvenile fish fluorescence microscope that Fig. 2 Semen Persicaes are intervened shows the grayscale format figure of figure.
The juvenile fish high power fluorescent microscope that Fig. 3 Semen Persicaes are intervened shows the grayscale format figure of figure.
The juvenile fish light microscopic figure that Fig. 4 positive controls-PTK787 intervenes.
The juvenile fish fluorescence microscope that Fig. 5 positive controls-PTK787 intervenes shows the grayscale format figure of figure.
The juvenile fish high power fluorescent microscope that Fig. 6 positive controls-PTK787 intervenes shows the grayscale format figure of figure.
The juvenile fish light microscopic figure that Fig. 7 negative controls-Vehicle Control (0.1%DMSO) intervenes.
The grayscale format figure of the juvenile fish fluorescence microscope display figure that Fig. 8 negative controls-Vehicle Control (0.1%DMSO) intervenes.
The gray scale lattice of the juvenile fish high power fluorescent microscope display figure that Fig. 9 negative controls-Vehicle Control (0.1%DMSO) intervenes
Formula figure.
Specific embodiment
Experimental technique described in following embodiments, if no special instructions, is conventional method；The reagent and material, such as without spy
It is different to illustrate, commercially obtain.
The test for investigating the medicinal new application of Semen Persicae is as follows：
Embodiment：
1. materials and methods
1.1 material
Chinese medicine is purchased from Sichuan return of spring hall Pharmaceuticals Ltd.All reagents be purchased from Sigma-Aldrich Co. (St.Louis,
MO), PTK787 (vatalanib) is purchased from Selleckchem.Tested using fli1a-EGFP transgenic zebrafishes.Brachydanio rerio
Raise according to standard environment.
1.2 preparation of reagents
Weigh Chinese medicine 450g, 8 times of amount decoctings boil 3 times, 1 hour every time, 3 decocting liquids are incorporated in dense on 800W electric furnaces
About 400ml is reduced to, after crossing 100 eye mesh screens (filtering residue keeps sample), is spread evenly across in evaporating dish, evaporating dish is placed in into electric heating drum
In wind drying baker, it is interrupted at 60 DEG C after being dried 62 hours, in continuing at glass desicator, drying at room temperature contains until making moisture
Amount<The extractum of 5% (oven drying method measure).
1.3 experimentation
The after fertilization embryo of 22 hours is put into in 12 orifice plates (per 30, hole embryo), is intervened 26 hours using Chinese medicine.Chinese medicine water extraction
Thing is dissolved in 0.1% dimethyl sulfoxide (DMSO), adds water extract of TCM concentration to be 200 μ g/ml per hole.Positive controls are
5 μ g/ml PTK787 (PTK787 vatalanib, a kind of vascular endothelial growth factor receptor antagonist), negative control group is 0.1%
DMSO.After fertilization 48 hours, tricaine anesthesia juvenile fish, is taken pictures using 1500 fluorescence microscopies of Nikon SMZ.Internode
Vascularization are the leading indicators for evaluating drug effect, while being also used for evaluating its toxicity.
1.4 results and conclusion
Using Semen Persicae, positive control-PTK787, the juvenile fish light microscopic figure of negative control-Vehicle Control interventions, fluorescence microscope
Show that figure (grayscale format figure), high power fluorescent microscope show that figure (grayscale format figure) is shown in Fig. 1-9 respectively.
The juvenile fish intervened using Semen Persicae and PTK787 occurs in that the defect of angiogenesis.Light microscopic and fluorescence microscope show, with
0.1%DMSO negative controls compare, the juvenile fish intervened using Semen Persicae, define less complete intersegmental blood vessel.High power lenses show
Show, be merely able to observe dorsal aorta Seedling once in a while.5 μ g/ml PTK787 positive controls can then completely inhibit intersegmental blood vessel and back
Longitudinal blood vessel.Semen Persicae does not find neurotoxicity or the organ toxicity of Semen Persicae without result in Brachydanio rerio death or teratogenesis.
To sum up, the present invention adopt Semen Persicae orSemen Persicae or Semen Persicae (parched) suppress tumor angiogenesis effect notable, are clinical suppression
Tumor angiogenesis and treatment tumor provide a kind of brand-new selection.
Claims (9)
1. Semen Persicae orThe purposes of Semen Persicae or Semen Persicae (parched) in the medicine for suppressing tumor angiogenesis is prepared.
2. purposes according to claim 1, it is characterised in that：Described medicine be with the Semen Persicae of effective dose orSemen Persicae
Or Semen Persicae (parched) is active component, according to the medicament that pharmacy conventional method is prepared from.
3. the pharmaceutical composition of tumor angiogenesis is suppressed, it is characterised in that：It is with the Semen Persicae of effective dose orSemen Persicae
Or Semen Persicae (parched) is active component, according to the medicament that pharmacy conventional method is prepared from.
4. it is according to claim 3 treatment tumor pharmaceutical composition, it is characterised in that：Described medicament is oral formulations
Or injection.
5. the pharmaceutical composition of the treatment tumor according to claim 3 or 4, it is characterised in that：Described medicament is per preparation
Unit contain Semen Persicae or5～30 grams of Semen Persicae or Semen Persicae (parched).
6. described in claim 3 suppression tumor angiogenesis pharmaceutical composition preparation method, it is characterised in that：Bag
Include following steps：
Method one：By Semen Persicae orSemen Persicae or Semen Persicae (parched) are ground into fine powder, mixing powder；Or
Method two：By Semen Persicae orSemen Persicae or Semen Persicae (parched) are ground into fine powder, encapsulated capsule；Or
Method three：By Semen Persicae orSemen Persicae or Semen Persicae (parched) are ground into fine powder, and tabletting is piece agent；Or
Method four：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, decoction liquor is filtered to obtain；Or
Method five：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, decoction liquor is filtered to obtain, decoction liquor is dried；Or
Method six：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, concentrated extracting solution makes granule, granule；
Or
Method seven：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, concentrated extracting solution makes granule, encapsulated
Capsule；Or
Method eight：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, concentrated extracting solution makes granule, and tabletting is i.e. in blocks
Agent；Or
Method nine：By Semen Persicae orAfter Semen Persicae or Semen Persicae (parched) water boiling and extraction, water decoction is made, or adds customary adjuvant to make mouth
Take liquid, syrup, mixture.
7. described in claim 3 suppression tumor angiogenesis pharmaceutical composition preparation method, it is characterised in that：Bag
Include following steps：
A, Semen Persicae orSemen Persicae or Semen Persicae (parched) are added water to cook, and filter to obtain decoction liquor；
B, it is dried decoction liquor and obtains final product.
8. it is according to claim 7 suppress tumor angiogenesis pharmaceutical composition preparation method, it is characterised in that：
Step B is dried decoction liquor and is less than 5% to water content.
9. described in claim 3 suppression tumor angiogenesis pharmaceutical composition preparation method, it is characterised in that：Bag
Include following steps：
A, Semen Persicae orSemen Persicae or Semen Persicae (parched) are added water to cook, and filter to obtain decoction liquor；
B, decoction liquor add customary adjuvant to be pharmaceutically prepared according to pharmacy conventional method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510652231.5A CN106563016A (en) | 2015-10-10 | 2015-10-10 | New uses of semen persicae |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510652231.5A CN106563016A (en) | 2015-10-10 | 2015-10-10 | New uses of semen persicae |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106563016A true CN106563016A (en) | 2017-04-19 |
Family
ID=58506709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510652231.5A Pending CN106563016A (en) | 2015-10-10 | 2015-10-10 | New uses of semen persicae |
Country Status (1)
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| CN (1) | CN106563016A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256146A (en) * | 1999-11-30 | 2000-06-14 | 罗科明 | Cancer treating medicine |
| CN101530464A (en) * | 2009-04-03 | 2009-09-16 | 司高 | Alcohol extract of walnut kernel and use thereof |
| CN103141876A (en) * | 2013-03-15 | 2013-06-12 | 安徽詹氏食品有限公司 | Xylitol pecan kernel and making method thereof |
-
2015
- 2015-10-10 CN CN201510652231.5A patent/CN106563016A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256146A (en) * | 1999-11-30 | 2000-06-14 | 罗科明 | Cancer treating medicine |
| CN101530464A (en) * | 2009-04-03 | 2009-09-16 | 司高 | Alcohol extract of walnut kernel and use thereof |
| CN103141876A (en) * | 2013-03-15 | 2013-06-12 | 安徽詹氏食品有限公司 | Xylitol pecan kernel and making method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 肖渊等: "观察12种活血祛瘀类中药对鸡胚绒毛尿囊膜新生血管生成的影响", 《药物分析杂志》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20170419 |