CN106535956A - Continuous blood purification apparatus - Google Patents

Continuous blood purification apparatus Download PDF

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Publication number
CN106535956A
CN106535956A CN201580035633.9A CN201580035633A CN106535956A CN 106535956 A CN106535956 A CN 106535956A CN 201580035633 A CN201580035633 A CN 201580035633A CN 106535956 A CN106535956 A CN 106535956A
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China
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fluid infusion
dialysis solution
liquid level
blood
pump
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CN106535956B (en
Inventor
山口泰广
西川勇作
吉田真
吉田真一
松本幸男
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JMS Co Ltd
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Japan Lifeline Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis

Abstract

The purpose of the present invention is to provide a continuous blood purification apparatus that can stop the substitution fluid pump, at least at the stage when the blood return chamber is filled with the substitution fluid, when the channel from the substitution fluid tank to the substitution fluid clamp is closed during operation of the substitution fluid pump. This continuous blood purification apparatus is provided with an extracorporeal blood circulation circuit (10), a dialysate channel (20), a substitution fluid channel (30), a waste fluid channel (40), a volume measurement means, and a control unit. The substitution fluid tank (31), the substitution fluid clamp (32) and the substitution fluid pump (33) are disposed in the substitution fluid channel (30). A substitution fluid branch channel (35), wherein are disposed a substitution fluid measuring solenoid valve (36), an upper substitution fluid level sensor (37), a substitution fluid measurement vessel (38) and a lower substitution fluid level sensor (39), is connected to the substitution fluid channel (30) between the substitution fluid clamp (32) and the substitution fluid pump (33). The control unit outputs a warning signal and a pump stop signal when a situation in which the substitution fluid level is positioned below the lower substitution fluid level sensor (39) continues for a certain time during the operation of the substitution fluid pump (33).

Description

Persistence blood purification device
Technical field
The present invention relates to the persistence blood purification dress of the hemodiafiltration therapy for being used for implementing last longer Put.
Background technology
From from the viewpoint of the drastically variation of the body fluid balance for preventing patient, and with the blood of hemodialysis and hemofiltration Dialysis filtration therapy continues the long time (such as more than 24 hours) and is carried out.
In the persistence blood purification device for implementing above-mentioned hemodiafiltration therapy, to dialysis solution, fluid infusion And the flow of waste liquid be managed this case it is of crucial importance.Accordingly, it would be desirable to respective flow is determined over time, and The rotating speed of liquid-feeding pump is modified in the case of difference is produced with respective setting flow etc. and controls flow so that with it is above-mentioned Setting flow is consistent.
In the past, proposed to have possess the capacity that can accurately determine dialysate flow, fluid infusion flow and waste liquid flow The persistence blood purification of formula metering units is with device (with reference to following patent documentations 1 and patent documentation 2).
Figure 10 is to illustrate to be used for the capacity formula metering for determining fluid infusion flow in existing persistence blood purification device The flow graph of unit.
In the figure, 80 is fluid infusion stream, and 81 is fluid infusion bottle, and 82 is fluid infusion folder, and 83 is fluid infusion pump, and 84 is to roll folder (roller clamp), 85 is fluid infusion branch flow passage, and 86 is fluid infusion metering electromagnetic valve, and 87 is upside fluid infusion liquid level sensor, 88 is fluid infusion measuring container, and 89 is downside fluid infusion liquid level sensor, and 90 is blood extracorporeal circulation loop, and 93 is blood back room, and 94 are Bubble detecting sensor, 95 is bubble folder.
As shown in Figure 10, it is configured with fluid infusion bottle 81, rolls folder 84, fluid infusion folder 82 and fluid infusion pump 83 in fluid infusion stream 80.
Fluid infusion stream 80 is the stream for being fed fluid infusion for court by the blood after blood purification (omitting diagram) purification, with The blood back room 93 for being connected to blood extracorporeal circulation loop 90 connects.In the blood extracorporeal circulation loop in the downstream of the blood back room 93 90 are configured with air bubble sensor 94 with bubble folder 95.
On the other hand, the fluid infusion stream 80 between fluid infusion folder 82 and fluid infusion pump 83 is connected with fluid infusion branch flow passage 85, The fluid infusion branch flow passage 85 as the capacity formula metering units for determining fluid infusion flow be configured with fluid infusion metering electromagnetic valve 86, Upside fluid infusion liquid level sensor 87, the fluid infusion measuring container 88 positioned at the position lower than fluid infusion bottle 81 and downside fluid infusion liquid level are passed Sensor 89.
In the persistence blood purification device of the capacity formula metering units possessed shown in Figure 10, by making fluid infusion pump Fluid infusion metering electromagnetic valve 86 is made to become "Off" state and make fluid infusion folder 82 become " opening " state in the state of 83 rotations, The fluid infusion in fluid infusion bottle 81 can be made to flow into blood back room 93 via fluid infusion stream 80.
In the persistence blood purification device, (i.e. off and on) as follows with separating predetermined time interval Determine fluid infusion flow.
That is, become " opening " state by making the fluid infusion metering electromagnetic valve 86 originally in "Off" state, make fluid infusion Fluid infusion in bottle 81 flows into blood back room 93 via fluid infusion stream 80, and also flows into fluid infusion meter via fluid infusion branch flow passage 85 Amount container 88.
And, rise in the liquid level of the fluid infusion for flowing into fluid infusion measuring container 88 and detected by upside fluid infusion liquid level sensor 87 After arriving, make fluid infusion folder 82 become "Off" state, thus, flow out the fluid infusion in fluid infusion measuring container 88.The fluid infusion flowed out Blood back room 93 is flowed into via fluid infusion branch flow passage 85 and fluid infusion stream 80.
Afterwards, the liquid level in the fluid infusion flowed out from fluid infusion measuring container 88 declines and is examined by downside fluid infusion liquid level sensor 89 After measuring, fluid infusion metering electromagnetic valve 86 is made to become "Off" state and make the decline of liquid level stop (now, the liquid level position of fluid infusion In fluid infusion branch flow passage 85), and make fluid infusion folder 82 become " opening " state (being back to the state before the measure of flow), by This, makes the fluid infusion in fluid infusion bottle 81 flow into blood back room 93 via fluid infusion stream 80.
And, detected by upside fluid infusion liquid level sensor 87 according to the liquid level of the fluid infusion flowed out from fluid infusion measuring container 88 certainly Time required for rising to being detected by downside fluid infusion liquid level sensor 89 and the discharge of fluid infusion during this period, Determine the fluid infusion flow of fluid infusion pump 83.
Patent documentation 1:No. 3180309 publications of Japanese Patent Publication No.
Patent documentation 2:Japanese Unexamined Patent Publication 2007-135908 publications
In the persistence blood purification device of the capacity formula metering units for possessing as shown in Figure 10, it is considered to forget to beat It is opened in the situation of changing the rolling folder 84 closed during fluid infusion bottle 81 (fluid infusion bag) or by not constituting the blood purification device Clip (pliers) oppress from fluid infusion bottle 81 to fluid infusion folder 82 fluid infusion stream 80 situation.In addition, it is also considered that be inserted in benefit The endoporus of the puncture needle (spike needle) of liquid bottle 81 (fluid infusion bag) produces the situation of blocking.
In this case, from fluid infusion bottle 81 to fluid infusion, the fluid infusion stream 80 of folder 82 is closed.
And, if fluid infusion pump 83 continues work in the state of the fluid infusion stream 80 of the folder 82 from fluid infusion bottle 81 to fluid infusion is closed Make (rotation), then (be in fluid infusion measuring container 88 and fluid infusion branch in the measure of fluid infusion flow in fluid infusion branch flow passage 85 In stream 85) fluid infusion attracted by fluid infusion pump 83, and sent into towards in fluid infusion measuring container 88 from fluid infusion metering with electromagnetic valve 86 Air, and then, or even the fluid infusion in the fluid infusion stream 80 in 83 downstream of fluid infusion pump and in blood back room 93 is all discharged (to blood Extracorporeal circulating circuit 90 is conveyed), blood back room 93 becomes the state of the sky being filled entirely with air.
Additionally, being usually above the fluid infusion metering electromagnetic valve 86 in "Off" state by the captivation that fluid infusion pump 83 is produced Airtight power, therefore, even if fluid infusion metering electromagnetic valve 86 be in "Off" state when be also possible to occur it is as described above Situation.
If blood back room 93 becomes empty state like this, bubble detecting sensor 94 detects the state, receives which The control unit (not shown) of detection signal stops fluid infusion pump 83.Thus, dialysis treatment is interrupted.
However, (making in the case where stopping fluid infusion pump 83 based on the detection signal from bubble detecting sensor 94 In the case that blood back room 93 becomes empty state), needs are carried out towards 93 interior filling fluid infusion of the blood back room, to entering in fluid infusion stream 80 Loaded down with trivial details operation as row aerofluxuss, and a certain degree of time is needed to dialysis treatment is started again at.
Accordingly, it is desirable to provide it is a kind of possess stop before blood back room 93 becomes empty state fluid infusion pump 83 be The persistence blood purification device of system.
Even if in addition, in the dialysate circuit for importing dialysis solution to blood purification, if in the dialysis positive work of liquid pump The stream pressed from both sides from dialysis solution bottle (dialyzate bag) to dialysis solution when making is closed, then it is assumed that air can be mixed into the mould of blood purification Block support (module holder).
The content of the invention
The present invention is completed based on situation as above.
It is an object of the invention to provide a kind of persistence blood purification device, the persistence blood purification has with device Standby capacity formula metering units, wherein, when the stream pressed from both sides from fluid infusion bottle to fluid infusion in the state of fluid infusion pump work is made is closed, Can stop fluid infusion pump in stage of the stream (at least blood back room) in the downstream of fluid infusion pump full of fluid infusion.
Another object of the present invention also resides in a kind of persistence blood purification device of offer, wherein, when making dialysis solution When the stream pressed from both sides from dialysis solution bottle to dialysis solution in the state of pump work is closed, can be in the stream in the downstream of dialysis liquid pump The stage of (at least dialysis solution hand-hole of blood purification) full of dialysis solution stops dialysis liquid pump.
(1) persistence blood purification device of the invention derives blood from the vein or tremulous pulse of patient, and will purification The vein of blood recovery afterwards to patient,
Above-mentioned persistence blood purification device is characterised by,
Possess：Blood extracorporeal circulation loop, above-mentioned blood extracorporeal circulation loop are from the vein or tremulous pulse of patient to quiet The closed circuit of arteries and veins, and it is configured with the blood purification being made up of filter for blood dialysis；Dialysate circuit, above-mentioned dialysis solution stream Road is for above-mentioned blood purification importing dialysis solution；Fluid infusion stream, above-mentioned fluid infusion stream is used for court will be by above-mentioned blood purification Blood after device is purified or purified by above-mentioned blood purification feeds the fluid infusion comprising body fluid components；Waste liquid stream, it is above-mentioned useless Liquid stream for by after blood purification waste liquid discharge；For the capacity formula metering units for determining fluid infusion flow off and on；And The control unit of the capacity formula metering units is controlled,
There are blood pump and above-mentioned blood purification in above-mentioned blood extracorporeal circulation loop configuration,
Dialysis solution bottle, dialysis solution folder and liquid pump of dialysing, above-mentioned dialysis solution stream is configured with successively in above-mentioned dialysate circuit Road is connected to the dialysis solution hand-hole of above-mentioned blood purification in the downstream of the allocation position of above-mentioned dialysis liquid pump,
Fluid infusion bottle, fluid infusion folder and fluid infusion pump is configured with successively in above-mentioned fluid infusion stream, and above-mentioned fluid infusion stream is in above-mentioned benefit The downstream of the allocation position of liquid pump is connected to above-mentioned blood extracorporeal circulation loop,
Above-mentioned fluid infusion stream between above-mentioned fluid infusion folder and above-mentioned fluid infusion pump is connected with fluid infusion branch flow passage, in the fluid infusion Branch flow passage is configured with fluid infusion metering electromagnetic valve, upside successively as the capacity formula metering units for determining fluid infusion flow and mends Liquid liquid level sensor, positioned at the fluid infusion measuring container and downside fluid infusion liquid level sensor of the position lower than above-mentioned fluid infusion bottle,
Outlet, waste liquid folder and waste drains pump is configured with successively in above-mentioned waste liquid stream, and above-mentioned waste liquid stream is above-mentioned useless The upstream side of the allocation position of liquid pump is connected to the dialysis solution tap of above-mentioned blood purification,
Above-mentioned control unit separate predetermined time interval control above-mentioned fluid infusion metering electromagnetic valve and above-mentioned fluid infusion folder Opening and closing, is calculated based on the detection information from above-mentioned upside fluid infusion liquid level sensor and above-mentioned downside fluid infusion liquid level sensor and is mended Flow quantity, also,
Above-mentioned downside fluid infusion liquid level sensor is compared on the lower when the liquid level of the fluid infusion when above-mentioned fluid infusion pump work is made is located at Position state continue for certain hour in the case of, output alarm produce signal.
(2) in the persistence blood purification device of the present invention, it is preferably formed into：Above-mentioned control unit is repeated as follows Control：
By in the state of above-mentioned fluid infusion pump rotation is made pressing from both sides into above-mentioned fluid infusion metering electromagnetic valve and above-mentioned fluid infusion For " opening " state, the fluid infusion in above-mentioned fluid infusion bottle is made to convey to above-mentioned blood extracorporeal circulation loop via fluid infusion stream, and Above-mentioned fluid infusion measuring container is flowed into via fluid infusion branch flow passage,
Rise in the liquid level of the fluid infusion for flowing into above-mentioned fluid infusion measuring container and detected by above-mentioned upside fluid infusion liquid level sensor After arriving, make above-mentioned fluid infusion folder become "Off" state, the fluid infusion in above-mentioned fluid infusion measuring container is made from the fluid infusion measuring container stream Go out and convey to above-mentioned blood extracorporeal circulation loop via above-mentioned fluid infusion branch flow passage and above-mentioned fluid infusion stream,
Decline in the liquid level of the fluid infusion flowed out from above-mentioned fluid infusion measuring container and examined by above-mentioned downside fluid infusion liquid level sensor After measuring, make above-mentioned fluid infusion folder become " opening " state, make the liquid level of fluid infusion rise so that the liquid level of the fluid infusion is located at and compare Above-mentioned downside fluid infusion liquid level sensor position by the top, then makes above-mentioned fluid infusion metering electromagnetic valve become "Off" state, And the fluid infusion in above-mentioned fluid infusion bottle is conveyed to above-mentioned blood extracorporeal circulation loop via above-mentioned fluid infusion stream,
Make above-mentioned fluid infusion metering electromagnetic valve become " opening " state with separating predetermined time interval；
In addition, above-mentioned control unit according to the liquid level of the fluid infusion flowed out from above-mentioned fluid infusion measuring container from by above-mentioned upside fluid infusion Liquid level sensor has detected the required delivery time (t1) till being detected by above-mentioned downside fluid infusion liquid level sensor And the discharge (V1) of fluid infusion during this period, fluid infusion flow (L1) is determined using formula L1=V1/t1.
(3) in the persistence blood purification device of above-mentioned (2), it is preferably formed into：Above-mentioned control unit is from above-mentioned benefit The liquid level of the fluid infusion that liquid measuring container flows out declines and after being detected by above-mentioned downside fluid infusion liquid level sensor, makes above-mentioned fluid infusion folder And above-mentioned fluid infusion metering electromagnetic valve maintains " opening " state, until the fluid infusion liquid level rise and by above-mentioned downside fluid infusion Till liquid level sensor is detected again.
(4) in the persistence blood purification device of the present invention, it is preferably formed into：Above-mentioned control unit is worked as makes above-mentioned benefit When liquid pump works, the liquid level of fluid infusion continue for one positioned at the state for comparing above-mentioned downside fluid infusion liquid level sensor position on the lower In the case of fixing time, output alarm produces signal, and exports the stop signal of above-mentioned fluid infusion pump.
(5) persistence blood purification device of the invention derives blood from the vein or tremulous pulse of patient, and will purification The vein of blood recovery afterwards to patient,
Above-mentioned persistence blood purification device is characterised by,
Possess：Blood extracorporeal circulation loop, above-mentioned blood extracorporeal circulation loop are from the vein or tremulous pulse of patient to quiet The closed circuit of arteries and veins, and it is configured with the blood purification being made up of filter for blood dialysis；Dialysate circuit, above-mentioned dialysis solution stream Road is for above-mentioned blood purification importing dialysis solution；Fluid infusion stream, above-mentioned fluid infusion stream is used for court will be by above-mentioned blood purification Blood after device is purified or purified by above-mentioned blood purification feeds the fluid infusion comprising body fluid components；Waste liquid stream, it is above-mentioned useless Liquid stream for by after blood purification waste liquid discharge；For the capacity formula metering units for determining dialysate flow off and on；With And control the control unit of the capacity formula metering units,
There are blood pump and above-mentioned blood purification in above-mentioned blood extracorporeal circulation loop configuration,
Dialysis solution bottle, dialysis solution folder and liquid pump of dialysing, above-mentioned dialysis solution stream is configured with successively in above-mentioned dialysate circuit Road is connected to the dialysis solution hand-hole of above-mentioned blood purification in the downstream of the allocation position of above-mentioned dialysis liquid pump,
Above-mentioned dialysate circuit between above-mentioned dialysis solution folder and above-mentioned dialysis liquid pump is connected with dialysis solution branch flow passage, Dialysis solution metering is configured with the dialysis solution branch flow passage successively as the capacity formula metering units for determining dialysate flow With electromagnetic valve, upside dialysis solution liquid level sensor, the dialysis solution measuring container positioned at the position lower than above-mentioned dialysis solution bottle and Downside dialysis solution liquid level sensor,
Fluid infusion bottle, fluid infusion folder and fluid infusion pump is configured with successively in above-mentioned fluid infusion stream, and above-mentioned fluid infusion stream is in above-mentioned benefit The downstream of the allocation position of liquid pump is connected to above-mentioned blood extracorporeal circulation loop,
Outlet, waste liquid folder and waste drains pump is configured with successively in above-mentioned waste liquid stream, and above-mentioned waste liquid stream is above-mentioned useless The upstream side of the allocation position of liquid pump is connected to the dialysis solution tap of above-mentioned blood purification,
Above-mentioned control unit separates predetermined time interval and controls above-mentioned dialysis solution metering electricity consumption magnet valve and above-mentioned dialysis solution The opening and closing of folder, is believed based on the detection from above-mentioned upside dialysis solution liquid level sensor and above-mentioned downside dialysis solution liquid level sensor Breath calculates dialysate flow, also,
Above-mentioned downside dialysis solution liquid level sensor is compared when the liquid level of the dialysis solution when above-mentioned dialysis solution pump work is made is located at In the case that the state of position on the lower continue for certain hour, output alarm produces signal.
(6) in the persistence blood purification device of above-mentioned (5), it is preferably formed into：
Above-mentioned control unit is repeated following control：
By in the state of above-mentioned dialysis liquid pump rotation is made making above-mentioned dialysis solution measure electricity consumption magnet valve and above-mentioned dialysis Liquid folder becomes " opening " state, makes the dialysis solution in above-mentioned dialysis solution bottle via above-mentioned dialysate circuit to above-mentioned blood purification The dialysis solution hand-hole conveying of device, and above-mentioned dialysis solution measuring container is flowed into via dialysis solution branch flow passage,
The liquid level of the dialysis solution for flowing into above-mentioned dialysis solution measuring container rise and by above-mentioned upside dialysis solution level sensing After device is detected, make above-mentioned dialysis solution folder become "Off" state, make the dialysis solution in above-mentioned dialysis solution measuring container saturating from this Analysis liquid measuring container flows out and via above-mentioned dialysis solution branch flow passage and above-mentioned dialysate circuit to above-mentioned blood purification Dialysis solution hand-hole conveying,
Decline in the liquid level for measuring the dialysis solution that container flow goes out from above-mentioned dialysis solution and passed by above-mentioned downside dialysis solution liquid level After sensor is detected, make above-mentioned dialysis solution folder become " opening " state, make the liquid level of dialysis solution rise so that the dialysis solution Liquid level is located at and compares above-mentioned downside dialysis solution liquid level sensor position by the top, then makes above-mentioned dialysis solution metering electricity consumption magnet valve Become "Off" state, and by the dialysis solution in above-mentioned dialysis solution bottle via above-mentioned dialysate circuit to above-mentioned blood purification Dialysis solution hand-hole conveying,
Make above-mentioned dialysis solution metering electricity consumption magnet valve become " opening " state with separating predetermined time interval；
In addition, above-mentioned control unit measures the liquid level of dialysis solution that container flow goes out from by above-mentioned upside according to from above-mentioned dialysis solution Dialysis solution liquid level sensor has detected required outflow till being detected by above-mentioned downside dialysis solution liquid level sensor The discharge (V2) of time (t2) and dialysis solution during this period, determines dialysate flow using formula L2=V2/t2 (L2)。
(7) in the persistence blood purification device of above-mentioned (6), it is preferably formed into：Above-mentioned control unit is from above-mentioned The liquid level of the dialysis solution that analysis liquid measuring container flows out declines and after being detected by above-mentioned downside dialysis solution liquid level sensor, makes above-mentioned Dialysis solution is pressed from both sides and above-mentioned dialysis solution metering electricity consumption magnet valve maintains " opening " state, until the liquid level of the dialysis solution rises and quilt Till above-mentioned downside dialysis solution liquid level sensor is detected again.
(8) in the persistence blood purification device of any one of above-mentioned (5)～(7), it is preferably formed into：Above-mentioned control Above-mentioned downside dialysis solution liquid level sensor is compared on the lower when the liquid level of the dialysis solution when above-mentioned dialysis solution pump work is made is located in portion Position state continue for certain hour in the case of, output alarm produces signal, and exports the stopping of above-mentioned dialysis liquid pump Signal.
(9) in the persistence blood purification device of the present invention, it is preferably formed into：
Possess for determining the capacity formula metering units of waste liquid flow off and on and controlling the capacity formula metering units Control unit,
Above-mentioned waste liquid stream between above-mentioned waste liquid folder and above-mentioned waste drains pump is connected with waste liquid branch flow passage, in the waste liquid Branch flow passage is configured with waste liquid metering electromagnetic valve, upside successively as the capacity formula metering units for determining waste liquid flow and gives up Liquid liquid level sensor, the waste liquid measuring container positioned at the low position of the dialysis solution tap than above-mentioned blood purification and downside Waste liquid liquid level sensor,
Above-mentioned control unit is repeated following control：
By make in the state of the rotation of above-mentioned waste drains pump is made above-mentioned waste liquid metering electromagnetic valve become " opening " state and Make above-mentioned waste liquid folder become "Off" state, waste liquid is flowed in above-mentioned waste liquid measuring container,
Rise in the liquid level of the waste liquid for flowing into above-mentioned waste liquid measuring container and detected by above-mentioned upside waste liquid liquid level sensor After arriving, make above-mentioned waste liquid folder become " opening " state, the waste liquid in above-mentioned waste liquid measuring container is thus made via above-mentioned waste liquid point Zhi Liulu and above-mentioned waste liquid stream are discharged from above-mentioned outlet,
Make above-mentioned waste liquid folder become "Off" state with separating predetermined time interval；
In addition, above-mentioned control unit always according to the liquid level from the waste liquid for flowing into above-mentioned waste liquid measuring container by above-mentioned downside waste liquid Liquid level sensor has detected required inlet time (t3) till being detected by above-mentioned upside waste liquid liquid level sensor And the influx (V3) of waste liquid during this period, waste liquid flow (L3) is determined using formula L3=V3/t3.
(10) in the persistence blood purification device described in above-mentioned (4) or (8), it is preferably formed into：In above-mentioned control During the stop signal of portion's output alarm generation signal and pump, stop above-mentioned blood pump.
(11) in the persistence blood purification device of the present invention, it is preferably formed into：Above-mentioned control unit control is above-mentioned Analysis liquid pump, above-mentioned fluid infusion pump and the respective rotating speed of above-mentioned waste drains pump, so that calculate with separating predetermined time interval Dialysate flow, fluid infusion flow and waste liquid flow are consistent with respective setting value.
(12) persistence blood purification device of the invention derives blood from the vein or tremulous pulse of patient, and will purification The vein of blood recovery afterwards to patient,
Above-mentioned persistence blood purification device is characterised by,
Possess：Blood extracorporeal circulation loop, above-mentioned blood extracorporeal circulation loop are from the vein or tremulous pulse of patient to quiet The closed circuit of arteries and veins, and it is configured with the blood purification being made up of transfusion filterses；Fluid infusion stream, above-mentioned fluid infusion stream are used for court Blood fluid infusion of the supply comprising body fluid components after being purified or be purified by above-mentioned blood purification by above-mentioned blood purification； Waste liquid stream, above-mentioned waste liquid stream for by after blood purification waste liquid discharge；For the capacity for determining fluid infusion flow off and on Formula metering units；And control the control unit of the capacity formula metering units,
There are blood pump and above-mentioned blood purification in above-mentioned blood extracorporeal circulation loop configuration,
Fluid infusion bottle, fluid infusion folder and fluid infusion pump is configured with successively in above-mentioned fluid infusion stream, and above-mentioned fluid infusion stream is in above-mentioned benefit The downstream of the allocation position of liquid pump is connected to above-mentioned blood extracorporeal circulation loop,
Above-mentioned fluid infusion stream between above-mentioned fluid infusion folder and above-mentioned fluid infusion pump is connected with fluid infusion branch flow passage, in the fluid infusion Branch flow passage is configured with fluid infusion metering electromagnetic valve, upside successively as the capacity formula metering units for determining fluid infusion flow and mends Liquid liquid level sensor, positioned at the fluid infusion measuring container and downside fluid infusion liquid level sensor of the position lower than above-mentioned fluid infusion bottle,
Outlet, waste liquid folder and waste drains pump is configured with successively in above-mentioned waste liquid stream, and above-mentioned waste liquid stream is above-mentioned useless The upstream side of the allocation position of liquid pump is connected to above-mentioned blood purification,
Above-mentioned control unit separate predetermined time interval control above-mentioned fluid infusion metering electromagnetic valve and above-mentioned fluid infusion folder Opening and closing, is calculated based on the detection information from above-mentioned upside fluid infusion liquid level sensor and above-mentioned downside fluid infusion liquid level sensor and is mended Flow quantity, also,
When above-mentioned fluid infusion pump work is made, the liquid level of fluid infusion is located at and compares above-mentioned downside fluid infusion liquid level sensor on the lower In the case that the state of position continue for certain hour, output alarm produces signal.
(13) persistence blood purification device of the invention derives blood from the vein or tremulous pulse of patient, and will purification The vein of blood recovery afterwards to patient,
Above-mentioned persistence blood purification device is characterised by,
Possess：Blood extracorporeal circulation loop, above-mentioned blood extracorporeal circulation loop are from the vein or tremulous pulse of patient to quiet The closed circuit of arteries and veins, and it is configured with the blood purification being made up of hemodialyzer；Dialysate circuit, above-mentioned dialysate circuit are used In to above-mentioned blood purification importing dialysis solution；Waste liquid stream, above-mentioned waste liquid stream for by after blood purification waste liquid discharge； For the capacity formula metering units for determining dialysate flow off and on；And control the control unit of the capacity formula metering units,
There are blood pump and above-mentioned blood purification in above-mentioned blood extracorporeal circulation loop configuration,
Dialysis solution bottle, dialysis solution folder and liquid pump of dialysing, above-mentioned dialysis solution stream is configured with successively in above-mentioned dialysate circuit Road is connected to the dialysis solution hand-hole of above-mentioned blood purification in the downstream of the allocation position of above-mentioned dialysis liquid pump,
Above-mentioned dialysate circuit between above-mentioned dialysis solution folder and above-mentioned dialysis liquid pump is connected with dialysis solution branch flow passage, Dialysis solution metering is configured with the dialysis solution branch flow passage successively as the capacity formula metering units for determining dialysate flow With electromagnetic valve, upside dialysis solution liquid level sensor, the dialysis solution measuring container positioned at the position lower than above-mentioned dialysis solution bottle and Downside dialysis solution liquid level sensor,
Outlet, waste liquid folder and waste drains pump is configured with successively in above-mentioned waste liquid stream, and above-mentioned waste liquid stream is above-mentioned useless The upstream side of the allocation position of liquid pump is connected to the dialysis solution tap of above-mentioned blood purification,
Above-mentioned control unit separates predetermined time interval and controls above-mentioned dialysis solution metering electricity consumption magnet valve and above-mentioned dialysis solution The opening and closing of folder, is believed based on the detection from above-mentioned upside dialysis solution liquid level sensor and above-mentioned downside dialysis solution liquid level sensor Breath calculates dialysate flow, also,
Above-mentioned downside dialysis solution liquid level sensor is compared when the liquid level of the dialysis solution when above-mentioned dialysis solution pump work is made is located at In the case that the state of position on the lower continue for certain hour, output alarm produces signal.
According to above-mentioned (1)～(4), the persistence blood purification device of (12), when in the state of fluid infusion pump work is made When the stream pressed from both sides from fluid infusion bottle to fluid infusion is closed, fluid infusion can be full of in the stream (at least blood back room) in the downstream of fluid infusion pump Stage make fluid infusion pump stop.Thus, after closed state is eliminated, dialysis treatment can be started again at short notice.
According to above-mentioned (5)～(8), the persistence blood purification device of (13), when in the state for making dialysis solution pump work Under the stream that presss from both sides from dialysis solution bottle to dialysis solution when being closed, can (at least blood be net in the stream in the downstream of dialysis liquid pump Change device dialysis solution hand-hole) full of dialysis solution stage make dialysis liquid pump stop.Thus, air will not be because of such closing The module carrier of blood purification is mixed into, after closed is eliminated state, dialysis treatment can be started again at short notice.
According to the persistence blood purification device of above-mentioned (9), additionally it is possible to accurately determine waste liquid flow.
According to the persistence blood purification device of above-mentioned (10), additionally it is possible to prevent above-mentioned fluid infusion pump or above-mentioned dialysis solution The solidification of blood when pump stops.
According to the persistence blood purification device of above-mentioned (11), additionally it is possible to accurately control dialysis solution, fluid infusion and give up The flow of liquid.
Description of the drawings
Fig. 1 is the flow graph of the persistence blood purification device involved by an embodiment of the invention.
Fig. 2 be illustrate in the persistence blood purification device shown in Fig. 1 control unit with for determining fluid infusion flow The block diagram of the annexation between capacity formula metering units.
Fig. 3 A are to illustrate the flow process for determining the action (step-A1～A7) of the capacity formula metering units of fluid infusion flow Figure.
Fig. 3 B are to illustrate the flow process for determining the action (step-A8～A16) of the capacity formula metering units of fluid infusion flow Figure.
Fig. 4 is the monitoring of the liquid level for illustrating that downside fluid infusion liquid level sensor is carried out and the control unit based on monitoring result The flow chart of action.
Fig. 5 be illustrate in the persistence blood purification device shown in Fig. 1 control unit with for determining dialysate flow Capacity formula metering units between annexation block diagram.
Fig. 6 A are to illustrate the stream for determining the action (step-C1～C7) of the capacity formula metering units of dialysate flow Cheng Tu.
Fig. 6 B are to illustrate the stream for determining the action (step-C8～C16) of the capacity formula metering units of dialysate flow Cheng Tu.
Fig. 7 is the monitoring of the liquid level for illustrating that downside dialysis solution liquid level sensor is carried out and the control unit based on monitoring result Action flow chart.
Fig. 8 be illustrate in the persistence blood purification device shown in Fig. 1 control unit with for determining waste liquid flow The block diagram of the annexation between capacity formula metering units.
Fig. 9 is to illustrate the flow chart for determining the action of the capacity formula metering units of waste liquid fluid flow.
Figure 10 is to illustrate to be used for the capacity formula metering for determining fluid infusion flow in existing persistence blood purification device The flow graph of the schematic configuration of unit.
Specific embodiment
Hereinafter, the persistence blood purification of the present invention is illustrated with device.
Persistence blood purification device 100 shown in Fig. 1 is to derive blood and by only from the vein or tremulous pulse of patient The persistence blood purification device of the vein of the blood recovery after change to patient.
＜ overall structures ＞
The persistence blood purification device 100 of present embodiment possesses：Blood extracorporeal circulation loop 10, the blood are external Closed circuit 10 is the closed circuit from the vein or tremulous pulse of patient to vein, and is configured with and is made up of filter for blood dialysis Blood purification 12；Dialysate circuit 20, for importing dialysis solution to blood purification 12；Fluid infusion stream 30, for by Blood after blood purification 12 is purified feeds the fluid infusion comprising body fluid components；Waste liquid stream 40, for by after blood purification Waste liquid is discharged；Capacity formula metering units, for the flow for determining dialysis solution, fluid infusion and waste liquid off and on independently of each other；With And control unit, control capability formula metering units.
In the blood extracorporeal circulation loop 10 for constituting blood purification device 100, from the side court of the blood for deriving patient By the side of blood recovery, blood pump 11 (roller pump), blood purification 12, blood back room 13, air bubble sensor is configured with successively 14 and bubble folder 15.16 is syringe pump, using the syringe pump 16 to the blood injection circulated in blood extracorporeal circulation loop 10 Anticoagulant.
In the dialysate circuit 20 for constituting blood purification device 100, dialysis solution bottle 21, dialysis solution folder is configured with successively 22nd, dialysis liquid pump 23 (roller pump) and heater 24, the dialysate circuit 20 is in the downstream of the allocation position of dialysis liquid pump 23 Side is connected to the dialysis solution hand-hole of blood purification 12.
In addition, the dialysate circuit 20 between dialysis solution folder 22 and dialysis liquid pump 23 is connected with dialysis solution branch flow passage 25, dialysis solution is configured with the dialysis solution branch flow passage 25 successively as the capacity formula metering units for determining dialysate flow Metering electromagnetic valve 26, upside dialysis solution liquid level sensor 27, the dialysis solution metering positioned at the position lower than dialysis solution bottle 21 hold Device 28 and downside dialysis solution liquid level sensor 29.
Fluid infusion bottle 31, fluid infusion folder 32 is configured with successively in the fluid infusion stream 30 for constituting blood purification device 100 and is mended Liquid pump 33 (roller pump), the fluid infusion stream 30 are connected to the blood of blood purification 12 in the downstream of the allocation position of fluid infusion pump 33 The blood extracorporeal circulation loop 10 (blood back room 13) of liquid discharge side.
In addition, the fluid infusion stream 30 between fluid infusion folder 32 and fluid infusion pump 33 is connected with fluid infusion branch flow passage 35, in the benefit Liquid branch flow passage 35 as the capacity formula metering units for determining fluid infusion flow be configured with successively fluid infusion metering electromagnetic valve 36, Upside fluid infusion liquid level sensor 37, the fluid infusion measuring container 38 positioned at the position lower than fluid infusion bottle 31 and downside fluid infusion liquid level are passed Sensor 39.
Outlet 41, waste liquid folder 42 is configured with successively in the waste liquid stream 40 for constituting blood purification device 100 and is given up Liquid pump 43 (roller pump), the waste liquid stream 40 are connected to the saturating of blood purification 12 in the upstream side of the allocation position of waste drains pump 43 Analysis liquid tap.
In addition, the waste liquid stream 40 between waste liquid folder 42 and waste drains pump 43 is connected with waste liquid branch flow passage 45, it is useless at this Liquid branch flow passage 45 as the capacity formula metering units for determining waste liquid flow be configured with successively waste liquid metering electromagnetic valve 46, Upside waste liquid liquid level sensor 47, positioned at low and higher than outlet 41 position of the dialysis solution tap than blood purification 12 Waste liquid measuring container 48 and downside waste liquid liquid level sensor 49.
The control unit 50 (not shown in Fig. 1) for constituting blood purification device 100 separates predetermined time interval control thoroughly Opening and closing of the analysis liquid metering with electromagnetic valve 26 and dialysis solution folder 22, based on from upside dialysis solution liquid level sensor 27 and downside The detection information of dialysis solution liquid level sensor 29 calculates dialysate flow.
In addition, the control unit 50 also separates predetermined time interval control fluid infusion metering electromagnetic valve 36 and fluid infusion folder 32 Opening and closing, based on from upside fluid infusion liquid level sensor 37 and downside fluid infusion liquid level sensor 39 detection information calculate fluid infusion Flow.
In addition, the control unit 50 also separates predetermined time interval control waste liquid metering electromagnetic valve 46 and waste liquid folder 42 Opening and closing, waste liquid is calculated based on the detection information from upside waste liquid liquid level sensor 47 and downside waste liquid liquid level sensor 49 Flow.
Also, the control unit 50 is when the liquid level of the dialysis solution when making dialysis liquid pump 23 work is positioned at than downside dialysis solution liquid level The state of sensor 29 (that is, downside dialysis solution liquid level sensor 29 detects air) more on the lower continue for the feelings of certain hour Under condition, signal is produced to the output alarm of warning devicess 60, and to the output stop signal of liquid pump 23 of dialysing.
Also, the control unit 50 is when the liquid level of the fluid infusion when making fluid infusion pump 33 work is positioned at than downside fluid infusion liquid level sensor In the case that the state of 39 (that is, downside fluid infusion liquid level sensor 39 detects air) more on the lower continue for certain hour, to The output alarm of warning devicess 60 produces signal, and exports stop signal to fluid infusion pump 33.
＜ fluid infusion flow path system ＞
Present embodiment blood purification with device 100, controlled with the dialysis that device 100 is carried out using blood purification Treat (hemodiafiltration therapy) in, with separating predetermined time interval (i.e. off and on) determine fluid infusion flow.Here, as " predetermined time interval " (measuring interval of fluid infusion flow), according to the different and different of fluid infusion flow etc., but for example, 1～20 Minute.
Hereinafter, the determination step of fluid infusion flow is illustrated using Fig. 1～Fig. 3 A and Fig. 3 B.
Here, Fig. 2 illustrates control unit and for determining the annexation between the capacity formula metering units of fluid infusion flow, should Control unit 50 shown in figure and fluid infusion folder 32, fluid infusion metering electromagnetic valve 36, upside fluid infusion liquid level sensor 37, downside fluid infusion liquid Level sensor 39, fluid infusion pump 33 and warning devicess 60 connect.
First, control unit 50 make fluid infusion pump 33 with based on fluid infusion setting flow rotary speed working (the step of Fig. 3 A- A1), and fluid infusion metering electromagnetic valve 36 and fluid infusion folder is made 32 to become " opening " state (step-A2).
Here, as the setting flow of fluid infusion, 10～3000mL/hr is set to, 500～1000mL/hr is preferably set to.
Thus, the fluid infusion in fluid infusion bottle 31 via fluid infusion stream 30 by blood extracorporeal circulation loop 10 (blood back room 13) Conveying, and 38 (step of fluid infusion measuring container is flowed into by the difference of height between fluid infusion bottle 31 via fluid infusion branch flow passage 35 Suddenly-A3).
Control unit 50 judges whether the liquid level of the fluid infusion for flowing into fluid infusion measuring container 38 rises and passed by upside fluid infusion liquid level Sensor 37 detects (horizontal level for reaching upside fluid infusion liquid level sensor 37) (step-A4), is being judged as what is be detected In the case of, fluid infusion folder 32 is become "Off" state and is cut off the supply (step-A5) of the fluid infusion for carrying out self-mending liquid bottle 31, make benefit (step-A6) is flowed out in fluid infusion in liquid measuring container 38.Fluid infusion from the outflow of fluid infusion measuring container 38 is via fluid infusion branch flow passage 35 and fluid infusion stream 30 and by blood extracorporeal circulation loop 10 (blood back room 13) convey.
Additionally, in step-A4, being judged as the liquid level of fluid infusion not by upside fluid infusion liquid level sensor 37 in control unit 50 In the case of detecting, return to step-A3 proceeds fluid infusion towards the inflow of fluid infusion measuring container 38.
Next, under whether control unit 50 judges the liquid level of the fluid infusion flowed out from fluid infusion measuring container 38 in step-A6 Drop and (step-A7) is detected by downside fluid infusion liquid level sensor 39, if being judged as being detected, (now, control unit 50 is obtained From being detected by upside fluid infusion liquid level sensor 37 till being detected by downside fluid infusion liquid level sensor 39 required for Delivery time (t1)), then make fluid infusion folder 32 become " opening " state (the step of Fig. 3 B-A8), make fluid infusion again flow into fluid infusion meter In amount container 38 (step-A9).
Additionally, in step-A7, the liquid level of the fluid infusion for being judged as declining in control unit 50 is not passed by downside fluid infusion liquid level In the case that sensor 39 is detected, return to step-A6 proceeds outflow (delivery time of the fluid infusion from fluid infusion measuring container 38 (t1) measurement).
Next, whether control unit 50 judges the liquid level of the fluid infusion for flowing into fluid infusion measuring container 38 in step-A9 by under Side fluid infusion liquid level sensor 39 detects (horizontal level for reaching downside fluid infusion liquid level sensor 39) (step-A10), if sentencing Break as being detected, then fluid infusion metering electromagnetic valve 36 is become "Off" state and fluid infusion is kept in fluid infusion measuring container 38 (step-A11), and the fluid infusion in fluid infusion bottle 31 is conveyed into (step via fluid infusion stream 30 to blood extracorporeal circulation loop 10 Suddenly-A12).
Additionally, in step-A10, the liquid level of the fluid infusion for being judged as rising in control unit 50 is not passed by downside fluid infusion liquid level In the case that sensor 39 is detected, return to step-A9 proceeds fluid infusion towards the inflow of fluid infusion measuring container 38.That is, fluid infusion Folder 32 and fluid infusion metering electromagnetic valve 36 maintain " opening " state, until the liquid level of fluid infusion rises and passed by downside fluid infusion liquid level Till sensor 39 is detected again.Thus, the fluid infusion measuring container 38 after the measurement of delivery time (t1), in dialysis treatment Fluid infusion is maintained inside, fluid infusion branch flow passage 35 is reliably full of by fluid infusion.
Additionally, making fluid infusion flow into fluid infusion measuring container 38 by making fluid infusion folder 32 become " opening " state (step-A8) Interior (step-A9), generally within the shorter time, the liquid level of fluid infusion will reach the level of downside fluid infusion liquid level sensor 39 Position, accordingly it is also possible to not execution step-A10, with from making fluid infusion folder 32 become " opening " state after certain hour It is controlled the mode that fluid infusion metering electromagnetic valve 36 becomes "Off" state.
Next, control unit 50 judges whether have passed through the time of regulation from the measure for starting previous fluid infusion flow (such as 1 minute) (step-A13), if control unit 50 is judged as have passed through the time of regulation, makes fluid infusion metering electromagnetic valve 36 become " opening " state (step-A14).
Additionally, in step-A13, in the case where control unit 50 is judged as the time without regulation, returning step Suddenly-A12, and proceed the operation for making the fluid infusion in fluid infusion bottle 31 convey to blood extracorporeal circulation loop 10.
Next, control unit 50 determines whether to terminate the state of the dialysis treatment carried out by blood purification device 100 (step-A15), in the case where the state of end is judged as YES, makes fluid infusion pump 33 stop (step-A16).
Additionally, in step-A15, be judged as be not terminate dialysis treatment state in the case of, return to step- A3, makes the fluid infusion in fluid infusion bottle 31 convey to blood extracorporeal circulation loop 10, and also flows into fluid infusion measuring container 38.
And, in step-A5～step-A8, according to the liquid level of the fluid infusion flowed out from fluid infusion measuring container 38 from quilt Upside fluid infusion liquid level sensor 37 has detected required above-mentioned till being detected by downside fluid infusion liquid level sensor 39 The discharge (V1) of delivery time (t1) and fluid infusion during this period, calculates fluid infusion flow using formula L1=V1/t1 (L1)。
The rotating speed of fluid infusion pump 33 is made to increase in the case where the fluid infusion flow (L1) for so calculating is lower than setting flow, Decline the rotating speed of fluid infusion pump 33 in the case that the fluid infusion flow (L1) for so calculating is higher than setting flow, thus make continuously The fluid infusion flow (L1) of measure is consistent with setting flow.
The control unit 50 for constituting blood purification device 100 is determining fluid infusion with separating predetermined time interval as mentioned above Flow and with this concurrently make fluid infusion pump 33 work when, continuously obtain the liquid of fluid infusion from downside fluid infusion liquid level sensor 39 Position is the information of top or lower section of fluid infusion liquid level sensor 39 on the downside of this, is located at downside fluid infusion liquid in the liquid level of fluid infusion In the case that the state of the lower section of level sensor 39 continue for certain hour, it is judged to the fluid infusion of the folder 32 from fluid infusion bottle 31 to fluid infusion Stream 30 is closed, and produces signal to the output alarm of warning devicess 60, and exports stop signal to fluid infusion pump 33.
Hereinafter, the step is illustrated using Fig. 4.
Under the state (the step of Fig. 4-B1) for making the work of fluid infusion pump 33, control unit 50 utilizes downside fluid infusion level sensing The fluid infusion of the allocation position (horizontal level) that device 39 pairs is present in fluid infusion liquid level sensor 39 on the downside of this or air are detected (step-B2).
Here, when air is detected using downside fluid infusion liquid level sensor 39, the liquid level of fluid infusion is in downside fluid infusion liquid The lower section of level sensor 39, in the case where fluid infusion is detected, the liquid level of fluid infusion is in the upper of downside fluid infusion liquid level sensor 39 Side.
So, downside fluid infusion liquid level sensor 39 detects that the liquid level of fluid infusion is positioned at downside fluid infusion liquid level sensor 39 all the time Allocation position (horizontal level) top or lower section.
Therefore, control unit 50 for example continuously judges whether to be detected by downside fluid infusion liquid level sensor 39 with 1 second interval Air (step-B3), in the case where being judged as detecting air, determines whether whether the state for detecting air continues Certain hour (step-B4), in the case where being judged as continue for certain hour, produces to the output alarm of warning devicess 60 Signal, and to output stop signal of fluid infusion pump 33 (step-B5).
Here, " certain hour " in step-B4 refer to can determine that be from fluid infusion bottle 31 to fluid infusion folder 32 fluid infusion stream The time of state of the road 30 in being closed, and be air is reached with the attraction of the fluid infusion carried out by fluid infusion pump 33 The time in the downstream (at least blood back room 13) of the fluid infusion pump 33, the time is according to from downside fluid infusion liquid level sensor 39 to fluid infusion The length of the stream of pump 33 it is different and different, but usually 2～30 seconds, preferably 3～10 seconds, if illustrating preferred one Individual example is then 5 seconds.
In the case where the time is too short, existing causes to produce the alarm that causes because of misoperation and fluid infusion pump 33 stops Misgivings.On the other hand, in the case of the overlong time, it is closed in the fluid infusion stream 30 of the folder 32 from fluid infusion bottle 31 to fluid infusion When, the stopping of fluid infusion pump 33 postpones, and when stopping, the stream in the downstream that cannot be formed as sometimes making fluid infusion pump 33 is full of fluid infusion State.
Additionally, by downside fluid infusion liquid level sensor 39 and air (detecting fluid infusion) ought be not detected by step-B3 In the case of or time for air being detected by downside fluid infusion liquid level sensor 39 in step-B4 feelings shorter than certain hour Under condition, return to step-B2, and proceed the detection of the fluid infusion or air performed by downside fluid infusion liquid level sensor 39.
Furthermore it is possible to the stop signal exported according to control unit 50 in step-B5 stops fluid infusion pump 33, and makes blood Liquid pump 11 stops, but it is also possible to proceeding the work (circulation of blood) of blood pump 11.By proceeding blood pump 11 Work, the solidification of the blood being prevented from when fluid infusion pump 33 stops.
As described above, present embodiment blood purification with device 100, it is characterised in that by constitute the blood it is net The downside fluid infusion liquid level sensor 39 of change device 100 is used as determining the detection of fluid infusion flow (determining the delivery time (t1)) Unit in addition using, and as the fluid infusion stream 30 for detection folder 32 from fluid infusion bottle 31 to fluid infusion whether in being closed The unit of state is used.
＜ dialysate circuit systems ＞
Present embodiment blood purification with device 100, controlled with the dialysis that device 100 is carried out using blood purification In treatment, with also separating predetermined time interval (i.e. off and on) determine dialysate flow.
Here, as " predetermined time interval " (measuring interval of dialysate flow), the measuring interval with fluid infusion flow It is identical.
Hereinafter, the determination step of dialysate flow is illustrated using Fig. 1, Fig. 5, Fig. 6 A and Fig. 6 B.Here, Fig. 5 Control unit is shown and for determining the annexation between the capacity formula metering units of dialysate flow, the control unit shown in the figure 50 measure electricity consumption magnet valve 26, upside dialysis solution liquid level sensor 27, downside dialysis solution level sensing with dialysis solution folder 22, dialysis solution Device 29, dialysis liquid pump 23 and warning devicess 60 connect.
First, control unit 50 makes dialysis liquid pump 23 work the (step of Fig. 6 A with the rotating speed of the setting flow based on dialysis solution Suddenly-C1), and make dialysis solution metering electricity consumption magnet valve 26 and dialysis solution folder 22 become " opening " state (step-C2).
Here, as the setting flow of dialysis solution, 10～4000mL/hr is set to, 500～1000mL/hr is preferably set to.
Thus, the dialysis solution in dialysis solution bottle 21 is noted by the dialysis solution to blood purification 12 via dialysate circuit 20 Enter hole conveying, and dialysis solution metering is flowed into by the difference of height between dialysis solution bottle 21 via dialysis solution branch flow passage 25 Container 28 (step-C3).
Control unit 50 judge the liquid level of the dialysis solution for flowing into dialysis solution measuring container 28 whether rise and by upside dialysis solution Liquid level sensor 27 detects (horizontal level of dialysis solution liquid level sensor 27 on the upside of reaching) (step-C4), is being judged as inspection In the case of measuring liquid level, dialysis solution folder 22 is made to become "Off" state and cut off the supply of the dialysis solution from dialysis solution bottle 21 (step-C5), and make the dialysis solution in dialysis solution measuring container 28 flow out (step-C6).Flow from dialysis solution measuring container 28 The dialysis solution for going out is injected by the dialysis solution to blood purification 12 via dialysis solution branch flow passage 25 and dialysate circuit 20 Hole conveys.
Additionally, in step-C4, being judged as the liquid level of dialysis solution not by upside dialysis solution level sensing in control unit 50 In the case that device 27 is detected, return to step-C3 proceeds dialysis solution towards the inflow of dialysis solution measuring container 28.
Next, control unit 50 judges that the liquid level of the dialysis solution flowed out from dialysis solution measuring container 28 in step-C6 is No decline and (step-C7) is detected by downside dialysis solution liquid level sensor 29, if being judged as, detecting liquid level (now, controls Portion 50 is obtained from being detected by upside dialysis solution liquid level sensor 27 until being detected by downside dialysis solution liquid level sensor 29 Till required for delivery time (t2).), then make dialysis solution folder 22 become " opening " state (the step of Fig. 6 B-C8), make Analysis liquid again flows into (step-C9) in dialysis solution measuring container 28.
Additionally, in step-C7, the liquid level of the dialysis solution for being judged as declining in control unit 50 is not by downside dialysis solution In the case that liquid level sensor 29 is detected, return to step-C6, and proceed dialysis solution from dialysis solution measuring container 28 Flow out (measurement of time (t2)).
Next, control unit 50 judges that the liquid level for flowing into the dialysis solution in dialysis solution measuring container 28 in step-C9 is It is no detected by downside dialysis solution liquid level sensor 29 (horizontal level for reaching downside dialysis solution liquid level sensor 29) (step- C10), if being judged as detecting liquid level, dialysis solution metering electricity consumption magnet valve 26 is made to become "Off" state and measure in dialysis solution Container 28 keep dialysis solution (step-C11), and by the dialysis solution in dialysis solution bottle 21 via dialysate circuit 20 to blood Dialysis solution hand-hole conveying (step-C12) of depurator 12.
Additionally, in step-C10, the liquid level of the dialysis solution for being judged as rising in control unit 50 is not by downside dialysis solution In the case that liquid level sensor 29 is detected, return to step-C9, and proceed dialysis solution towards dialysis solution measuring container 28 Flow into.That is, dialysis solution folder 22 and dialysis solution metering electricity consumption magnet valve 26 maintain " opening " state, until on the liquid level of dialysis solution Rise and till being detected by downside dialysis solution liquid level sensor 29 again.Thus, after the measurement of delivery time (t2), in dialysis Dialysis solution is maintained in dialysis solution measuring container 28 in treatment, and dialysis solution branch flow passage 25 is reliably full of by dialysis solution.
Additionally, making dialysis solution flow into dialysis solution metering by making dialysis solution folder 22 become " opening " state (step-C8) In container 28 (step-C9), generally within the shorter time, the liquid level of dialysis solution will reach downside dialysis solution level sensing The horizontal level of device 29, accordingly it is also possible to not execution step-C10, and with from making dialysis solution folder 22 become " opening " state The mode that rising makes dialysis solution metering electricity consumption magnet valve 26 become "Off" state after certain hour is controlled.
Next, control unit 50 judges whether have passed through the time of regulation from the measure for starting previous dialysate flow (such as 1 minute) (step-C13), if control unit 50 is judged as have passed through the time of regulation, makes dialysis solution measure electricity consumption magnetic Valve 26 becomes " opening " state (step-C14).
Additionally, in step-C13, it is judged as in control unit 50 and in the case of time without regulation, returns step Suddenly-C12, continues to make the dialysis solution in dialysis solution bottle 21 convey to the dialysis solution hand-hole of blood purification 12.
Next, control unit 50 determines whether to terminate the state of the dialysis treatment carried out by blood purification device 100 (step-C15), in the case where the state of end is judged as YES, makes dialysis liquid pump 23 stop (step-C16).
Additionally, in step-C15, be judged as be not terminate dialysis treatment state in the case of, return to step- C3, make the conveying of dialysis solution hand-hole from dialysis solution in dialysis solution bottle 21 to blood purification 12, and also flow into dialysate meter Amount container 28.
And, in step-C5～step-C8, according to the liquid level of the dialysis solution flowed out from dialysis solution measuring container 28 From being detected by upside dialysis solution liquid level sensor 27 till being detected by downside dialysis solution liquid level sensor 29 needed for The above-mentioned delivery time (t2) wanted and the discharge (V2) of dialysis solution during this period, are calculated using formula L2=V2/t2 Dialysate flow (L2).
Make on the rotating speed of dialysis liquid pump 23 in the case where the dialysate flow (L2) for so calculating is lower than setting flow Rise, decline the rotating speed of dialysis liquid pump 23 in the case where the dialysate flow (L2) for so calculating is higher than setting flow, by This makes the dialysate flow (L2) for continuously determining consistent with setting flow.
The control unit 50 for constituting blood purification device 100 is determining dialysis with separating predetermined time interval as mentioned above Flow quantity and when concurrently making dialysis liquid pump 23 work with this, continuously obtains saturating from downside dialysis solution liquid level sensor 29 The liquid level of analysis liquid is the information of top or lower section of dialysis solution liquid level sensor 29 on the downside of this, in the liquid level position of dialysis solution In the case that on the downside of comparing, the state of the position on the lower of dialysis solution liquid level sensor 29 continue for certain hour, fill to alarm Put 60 conveying alarms and produce signal, and to the output stop signal of liquid pump 23 of dialysing.
Hereinafter, the step is illustrated using Fig. 7.
Under the state (the step of Fig. 7-D1) for making the work of dialysis liquid pump 23, control unit 50 utilizes downside dialysis solution liquid level Sensor 29 pairs is present in the dialysis solution or air of the allocation position (horizontal level) of downside dialysis solution liquid level sensor 29 and enters Row detection (step-D2).
Here, when air is detected using downside dialysis solution liquid level sensor 29, the liquid level of dialysis solution is saturating in downside The lower section of analysis liquid liquid level sensor 29, in the case where dialysis solution is detected, the liquid level of dialysis solution is in downside dialysis solution liquid level The top of sensor 29.
So, downside dialysis solution liquid level sensor 29 detects that the liquid level of dialysis solution is passed positioned at downside dialysis solution liquid level all the time The top or lower section of the allocation position (horizontal level) of sensor 29.
Therefore, control unit 50 for example continuously judges whether to be detected by downside dialysis solution liquid level sensor 29 with 1 second interval To air (step-D3), in the case where being judged as detecting air, determine whether whether the state for detecting air holds Certain hour (step-D4) is continued, in the case where being judged as continue for certain hour, has produced to the output alarm of warning devicess 60 Raw signal, and to output stop signal of liquid pump 23 (step-D5) of dialysing.
Here, as step-D4 in " certain hour ", refer to can determine that be from dialysis solution bottle 21 to dialysis solution press from both sides The time of state of 22 dialysate circuit 20 in being closed, and be not make air saturating with what is carried out by dialysis liquid pump 23 Analyse the attraction of liquid and reach the time in the downstream (at least dialysis solution hand-hole of blood purification 12) of the dialysis liquid pump 23, should Time according to from downside dialysis solution liquid level sensor 29 to the stream of dialysis liquid pump 23 length it is different and different, but be usually 2～30 seconds, preferably 3～10 seconds, be 5 seconds if a preferred example is illustrated.
In the case where the time is too short, existing causes to produce the alarm that causes because of misoperation and dialysis liquid pump 23 stops Misgivings.On the other hand, in the case of the overlong time, in the dialysate circuit 20 of the folder 22 from dialysis solution bottle 21 to dialysis solution When being closed, the stopping of liquid pump 23 of dialysing postpones, when stopping, the stream in the downstream that cannot be formed as sometimes making dialysis liquid pump 23 State of the road full of dialysis solution.
Additionally, when in step-D3 by downside dialysis solution liquid level sensor 29 and being not detected by air and (detect dialysis Liquid) in the case of or detected the time of air by downside dialysis solution liquid level sensor 29 than a timing in step-D4 Between it is short in the case of, return to step-D2, and the dialysis solution that proceeds to be performed by downside dialysis solution liquid level sensor 29 or The detection of air.
Furthermore it is possible to the stop signal exported according to control unit 50 in step-D5 stops dialysis liquid pump 23, and makes Blood pump 11 stops, but can continue to carry out the work (circulation of blood) of blood pump 11.By proceeding blood pump 11 work, the solidification of the blood being prevented from when dialysis liquid pump 23 stops.
As described above, present embodiment blood purification with device 100, it is characterised in that blood purification will be constituted With the downside dialysis solution liquid level sensor 29 of device 100 as determining the inspection of dialysate flow (determining the delivery time (t2)) Survey unit used, and as detection from dialysis solution bottle 21 to dialysis solution press from both sides 22 dialysate circuit 20 whether be in The unit of the state being closed is used.
＜ waste liquid flow path system ＞
Present embodiment blood purification with device 100, controlled with the dialysis that device 100 is carried out using blood purification In treatment, with also separating predetermined time interval (i.e. off and on) determine waste liquid flow.
Here, as " predetermined time interval " (measuring interval of waste liquid flow), the measuring interval phase with fluid infusion flow Together.
Hereinafter, the determination step of dialysate flow is illustrated using Fig. 1, Fig. 8 and Fig. 9.
Here, Fig. 8 illustrates control unit and for determining the annexation between the capacity formula metering units of waste liquid flow, should Control unit 50 shown in figure and waste liquid folder 42, waste liquid metering electromagnetic valve 46, upside waste liquid liquid level sensor 47, downside waste liquid liquid Level sensor 49, waste drains pump 43 and warning devicess 60 connect.
First, control unit 50 makes waste drains pump 43 rotate (the step of Fig. 9-E1) with the rotating speed of the setting flow based on waste liquid, And make waste liquid metering electromagnetic valve 46 become " opening " state, make waste liquid folder 42 become "Off" state (step-E2).
Thus, from blood purification 12 dialysis solution tap waste liquid via waste liquid stream 40 and waste liquid affluent-dividing Road 45 and flow into waste liquid measuring container 48 (step-E3).
Control unit 50 judges whether the liquid level of the waste liquid for flowing into waste liquid measuring container 48 rises and passed by downside waste liquid liquid level Sensor 49 and upside waste liquid liquid level sensor 47 detect (obtain from being detected by downside waste liquid liquid level sensor 49 until Inlet time (t3) required for till being detected by upside waste liquid liquid level sensor 47) (step-E4).
And, in the case where being judged as detecting liquid level, make waste liquid folder 42 become " opening " state (step-E5), make Waste liquid in waste liquid measuring container 48 discharges (step-E6) via waste liquid branch flow passage and waste liquid stream from outlet 41.
Additionally, in step-E4, in the case where control unit 50 is judged as not detecting liquid level, return to step-E3, after The continuous inflow for carrying out waste liquid from the dialysis solution tap of blood purification 12 towards waste liquid measuring container 48.
Next, control unit 50 judges whether have passed through the time of regulation from the measure for starting previous waste liquid flow (such as 1 minute) (step-E7), if being judged as have passed through the time of regulation, makes waste liquid folder 42 become "Off" state (step Suddenly-E8).
Additionally, in step-E7, in the case where control unit 50 is judged as the time without regulation, return to step- E6, makes waste liquid discharge from outlet 41.
Next, control unit 50 determines whether to terminate the state of the dialysis treatment carried out by blood purification device 100 (step-E9), in the case where the state of end is judged as YES, makes waste drains pump 43 stop (step-E10).
Additionally, in step-E9, in the case where being judged as not being end dialysis treatment, return to step-E3 continues Waste liquid is carried out towards the inflow of waste liquid measuring container 48.
And, in step-E2～step-E5, according to the liquid level of the waste liquid for flowing into waste liquid measuring container 48 from by under When side waste liquid liquid level sensor 49 has detected the inflow required for till being detected by upside waste liquid liquid level sensor 47 Between (t3) and waste liquid during this period influx (V3), calculate waste liquid flow (L3) using formula L3=V3/t3.
According to the blood purification device 100 of present embodiment, when in the state of making fluid infusion pump 33 work from fluid infusion bottle When the 31 fluid infusion streams 30 for pressing from both sides 32 to fluid infusion are closed, if control unit 50 is identified being detected by downside fluid infusion liquid level sensor 39 The state of air (liquid level of fluid infusion is located at the lower section of the allocation position of downside fluid infusion liquid level sensor 39) continue for certain hour (such as 5 seconds), then producing signal by based on the situation alarm exported by control unit 50 makes warning devicess 60 produce police Report, and the stop signal exported by the control unit 50 stops fluid infusion pump 33, thereby, it is possible in the downstream of fluid infusion pump 33 Stream (at least blood back room 13) fluid infusion pump 33 is stopped immediately full of stage of fluid infusion.Thus, in such closed state quilt After elimination, dialysis treatment can be started again at short notice.
In addition, according to the blood purification device 100 of present embodiment, when in the state of making dialysis liquid pump 23 work from Dialysis solution bottle 21 to dialysis solution folder 22 dialysate circuit 20 be closed when, if control unit 50 is identified by downside dialysis solution liquid level Sensor 29 detects air (liquid level of dialysis solution is located at the lower section of the allocation position of downside dialysis solution liquid level sensor 29) State continue for certain hour (such as 5 seconds), then produce signal by based on the situation alarm exported by control unit 50 Make warning devicess 60 produce alarm, and the stop signal exported by the control unit 50 makes dialysis liquid pump 23 stop immediately, by This, can be full of dialysis solution in the stream (at least dialysis solution hand-hole of blood purification 12) in the downstream of dialysis liquid pump 23 Stage stops dialysis liquid pump 23.Thus, air will not be mixed into the module carrier of blood purification 12 because of such closing, After closed state is eliminated, dialysis treatment can be started again at short notice.
Above an embodiment of the persistence blood purification device of the present invention is illustrated, but the present invention is simultaneously This is not limited to, various changes can be carried out.
For example, downside fluid infusion liquid is compared when the liquid level of the fluid infusion (dialysis solution) when making fluid infusion pump (dialysis liquid pump) work is located at In the case that the state of level sensor (downside dialysis solution liquid level sensor) position on the lower continue for certain hour, it is also possible to Only export alarm and produce signal.In this case, by the operator for noticing alarm stopping fluid infusion pump (dialysis liquid pump).
In addition, constituting the blood of fluid infusion stream 30 of the blood purification of present embodiment with device 100 and blood purification 12 The blood extracorporeal circulation loop 10 of liquid discharge side connects (the blood supply fluid infusion to after being purified by blood purification 12), but also may be used Fluid infusion stream 30 is connected with the blood extracorporeal circulation loop 10 in the blood introduction side of blood purification 12 (can also be to by blood Blood before liquid purifier 12 is purified feeds fluid infusion).
In addition, the persistence blood purification device of the present invention can also possess the hemofiltration as blood purification Device, but there is no dialysate circuit, dialysis solution branch flow passage and be configured at the persistence blood of the element of these streams Filtering device.
Also, the persistence blood purification device of the present invention can also possess the hemodialysis as blood purification Device, but there is no fluid infusion stream, fluid infusion branch flow passage and be configured at the maintenance hemodialysis of the element of these streams Device.
Description of reference numerals
100：Persistence blood purification device；10：Blood extracorporeal circulation loop；11：Blood pump；12：Blood purification； 13：Blood back room；14：Air bubble sensor；15：Bubble is pressed from both sides；16：Syringe pump；20：Dialysate circuit；21：Dialysis solution bottle；22：Dialysis Liquid is pressed from both sides；23：Dialysis liquid pump；24：Heater；25：Dialysis solution branch flow passage；26：Dialysis solution metering electricity consumption magnet valve (measure by capacity formula Unit)；27：Upside dialysis solution liquid level sensor (capacity formula metering units)；28：(metering of capacity formula is single for dialysis solution measuring container Unit)；29：Downside dialysis solution liquid level sensor (capacity formula metering units)；30：Fluid infusion stream；31：Fluid infusion bottle；32：Fluid infusion is pressed from both sides； 33：Fluid infusion pump；35：Fluid infusion branch flow passage；36：Fluid infusion metering electromagnetic valve (capacity formula metering units)；37：Upside fluid infusion liquid level Sensor (capacity formula metering units)；38：Fluid infusion measuring container (capacity formula metering units)；39：Downside fluid infusion liquid level sensor (capacity formula metering units)；40：Waste liquid stream；41：Outlet；42：Waste liquid is pressed from both sides；43：Waste drains pump；45：Waste liquid branch flow passage； 46：Waste liquid metering electromagnetic valve (capacity formula metering units)；47：Upside waste liquid liquid level sensor (capacity formula metering units)；48： Waste liquid measuring container (capacity formula metering units)；49：Downside waste liquid liquid level sensor (capacity formula metering units)；50：Control unit； 60：Warning devicess.

Claims (13)

1. a kind of persistence blood purification device, derives blood from the vein or tremulous pulse of patient, and by the blood after purification The vein of patient is fed back to,
The persistence blood purification device is characterised by,
Possess：Blood extracorporeal circulation loop (10), blood extracorporeal circulation loop (10) are the veins or tremulous pulse from patient To the closed circuit of vein, and it is configured with the blood purification (12) being made up of filter for blood dialysis；Dialysate circuit (20), Dialysate circuit (20) are for the blood purification (12) importing dialysis solution；Fluid infusion stream (30), the fluid infusion stream The blood that road (30) is used for towards after will be purified or purified by the blood purification (12) by the blood purification (12) is mended To the fluid infusion comprising body fluid components；Waste liquid stream (40), waste liquid stream (40) for by after blood purification waste liquid discharge； For the capacity formula metering units for determining fluid infusion flow off and on；And control the control unit of the capacity formula metering units,
Blood pump (11) and the blood purification (12) are configured with blood extracorporeal circulation loop (10),
Dialysis solution bottle (21), dialysis solution folder (22) and dialysis liquid pump (23) is configured with successively in the dialysate circuit (20), Dialysate circuit (20) are connected to the blood purification in the downstream of the allocation position of dialysis liquid pump (23) (12) dialysis solution hand-hole,
Fluid infusion bottle (31), fluid infusion folder (32) and fluid infusion pump (33), the fluid infusion is configured with successively in fluid infusion stream (30) Stream (30) is connected to blood extracorporeal circulation loop (10) in the downstream of the allocation position of fluid infusion pump (33),
Fluid infusion stream (30) between (32) and fluid infusion pump (33) are pressed from both sides in the fluid infusion and is connected with fluid infusion branch flow passage (35), based on the fluid infusion branch flow passage (35) is configured with fluid infusion successively as the capacity formula metering units by determining fluid infusion flow Amount electromagnetic valve (36), upside fluid infusion liquid level sensor (37), the fluid infusion positioned at the position lower than fluid infusion bottle (31) are measured Container (38) and downside fluid infusion liquid level sensor (39),
Outlet (41), waste liquid folder (42) and waste drains pump (43), the waste liquid is configured with successively in waste liquid stream (40) Stream (40) is connected to the dialysis solution row of the blood purification (12) in the upstream side of the allocation position of the waste drains pump (43) Portal,
The control unit separates predetermined time interval and controls fluid infusion metering electromagnetic valve (36) and fluid infusion folder (32) opening and closing, based on from upside fluid infusion liquid level sensor (37) and the downside fluid infusion liquid level sensor (39) Detection information calculates fluid infusion flow, also,
Compare downside fluid infusion liquid level sensor (39) and lean on when the liquid level of the fluid infusion when making described fluid infusion pump (33) to work is located at In the case that the state of the position of lower section continue for certain hour, output alarm produces signal.
2. persistence blood purification device according to claim 1, it is characterised in that
The control unit is repeated following control：
By making fluid infusion metering electromagnetic valve (36) and the fluid infusion in the state of described fluid infusion pump (33) rotation is made Folder (32) becomes " opening " state, makes the fluid infusion in fluid infusion bottle (31) external to the blood via fluid infusion stream (30) Closed circuit (10) is conveyed, and flows into fluid infusion measuring container (38) via fluid infusion branch flow passage (35),
Flow into fluid infusion measuring container (38) fluid infusion liquid level rise and by upside fluid infusion liquid level sensor (37) After detecting, make fluid infusion folder (32) become "Off" state, the fluid infusion in fluid infusion measuring container (38) is made from the benefit Liquid measuring container (38) flows out and via fluid infusion branch flow passage (35) and the fluid infusion stream (30) to the blood Extracorporeal circulating circuit (10) is conveyed,
The fluid infusion flowed out from fluid infusion measuring container (38) liquid level decline and by the downside fluid infusion liquid level sensor (39), after detecting, make fluid infusion folder (32) become " opening " state, make the liquid level of fluid infusion rise so that the liquid of the fluid infusion Face is located at and compares downside fluid infusion liquid level sensor (39) position by the top, then makes the fluid infusion metering electromagnetic valve (36) become "Off" state, and by the fluid infusion in fluid infusion bottle (31) via fluid infusion stream (30) to the blood Extracorporeal circulating circuit (10) is conveyed,
Make fluid infusion metering electromagnetic valve (36) to become " opening " state with separating predetermined time interval；
In addition, the control unit according to the liquid level of the fluid infusion flowed out from fluid infusion measuring container (38) from by the upside fluid infusion Liquid level sensor (37) has detected required outflow till being detected by downside fluid infusion liquid level sensor (39) The discharge (V1) of time (t1) and fluid infusion during this period, determines fluid infusion flow (L1) using formula L1=V1/t1.
3. persistence blood purification device according to claim 2, it is characterised in that
The control unit the fluid infusion flowed out from fluid infusion measuring container (38) liquid level decline and by the downside fluid infusion liquid After level sensor (39) is detected, fluid infusion folder (32) and the fluid infusion metering electromagnetic valve (36) is made to maintain " opening " State, till the liquid level rising of the fluid infusion is detected again by downside fluid infusion liquid level sensor (39).
4. the persistence blood purification device according to any one of claims 1 to 3, it is characterised in that
The control unit compares the downside fluid infusion liquid level biography when the liquid level of the fluid infusion when making described fluid infusion pump (33) to work is located at In the case that the state of sensor (39) position on the lower continue for certain hour, output alarm produces signal, and exports described The stop signal of fluid infusion pump (33).
5. a kind of persistence blood purification device, derives blood from the vein or tremulous pulse of patient, and by the blood after purification The vein of patient is fed back to,
The persistence blood purification device is characterised by,
Possess：Blood extracorporeal circulation loop (10), blood extracorporeal circulation loop (10) are the veins or tremulous pulse from patient To the closed circuit of vein, and it is configured with the blood purification (12) being made up of filter for blood dialysis；Dialysate circuit (20), Dialysate circuit (20) are for the blood purification (12) importing dialysis solution；Fluid infusion stream (30), the fluid infusion stream The blood that road (30) is used for towards after will be purified or purified by the blood purification (12) by the blood purification (12) is mended To the fluid infusion comprising body fluid components；Waste liquid stream (40), waste liquid stream (40) for by after blood purification waste liquid discharge； For the capacity formula metering units for determining dialysate flow off and on；And control the control unit of the capacity formula metering units,
Blood pump (11) and the blood purification (12) are configured with blood extracorporeal circulation loop (10),
Dialysis solution bottle (21), dialysis solution folder (22) and dialysis liquid pump (23) is configured with successively in the dialysate circuit (20), Dialysate circuit (20) are connected to the blood purification in the downstream of the allocation position of dialysis liquid pump (23) (12) dialysis solution hand-hole,
The dialysate circuit (20) between (22) and dialysis liquid pump (23) is pressed from both sides in the dialysis solution and is connected with dialysis solution Branch flow passage (25), the dialysis solution branch flow passage (25) as determine dialysate flow capacity formula metering units successively Be configured with dialysis solution metering electricity consumption magnet valve (26), upside dialysis solution liquid level sensor (27), positioned at than dialysis solution bottle (21) The dialysis solution measuring container (28) of low position and downside dialysis solution liquid level sensor (29),
Fluid infusion bottle (31), fluid infusion folder (32) and fluid infusion pump (33), the fluid infusion is configured with successively in fluid infusion stream (30) Stream (30) is connected to blood extracorporeal circulation loop (10) in the downstream of the allocation position of fluid infusion pump (33),
Outlet (41), waste liquid folder (42) and waste drains pump (43), the waste liquid is configured with successively in waste liquid stream (40) Stream (40) is connected to the dialysis solution row of the blood purification (12) in the upstream side of the allocation position of the waste drains pump (43) Portal,
The control unit separates predetermined time interval and controls dialysis solution metering electricity consumption magnet valve (26) and the dialysis solution The opening and closing of folder (22), based on from upside dialysis solution liquid level sensor (27) and the downside dialysis solution liquid level sensor (29) detection information calculates dialysate flow, also,
The downside dialysis solution liquid level sensor is compared when the liquid level of the dialysis solution when making dialysis liquid pump (23) work is located at (29), in the case that the state of position on the lower continue for certain hour, output alarm produces signal.
6. persistence blood purification device according to claim 5, it is characterised in that
The control unit is repeated following control：
Electricity consumption magnet valve (26) and described is measured by making the dialysis solution in the state of dialysis liquid pump (23) rotation is made Dialysis solution folder (22) becomes " opening " state, makes the dialysis solution in dialysis solution bottle (21) via the dialysate circuit (20) And convey to the dialysis solution hand-hole of the blood purification (12), and flow into via dialysis solution branch flow passage (25) described Analysis liquid measuring container (28),
Flow into dialysis solution measuring container (28) dialysis solution liquid level rise and by the upside dialysis solution level sensing After device (27) is detected, make dialysis solution folder (22) become "Off" state, make in dialysis solution measuring container (28) Dialysis solution is flowed out from the dialysis solution measuring container (28) and via dialysis solution branch flow passage (25) and the dialysis solution stream Road (20) and to the blood purification (12) dialysis solution hand-hole convey,
Decline in the liquid level of the dialysis solution flowed out from dialysis solution measuring container (28) and passed by the downside dialysis solution liquid level After sensor (29) is detected, make dialysis solution folder (22) become " opening " state, make the liquid level of dialysis solution rise so that this The liquid level of dialysis solution is located at and compares downside dialysis solution liquid level sensor (29) position by the top, then makes the dialysis solution Metering electromagnetic valve (26) becomes "Off" state, and by the dialysis solution in dialysis solution bottle (21) via the dialysis solution stream Road (20) and to the blood purification (12) dialysis solution hand-hole convey,
Make dialysis solution metering electricity consumption magnet valve (26) become " opening " state with separating predetermined time interval；
In addition, the control unit according to the liquid level of the dialysis solution flowed out from dialysis solution measuring container (28) from by the upside Needed for dialysis solution liquid level sensor (27) has been detected till being detected by downside dialysis solution liquid level sensor (29) The delivery time (t2) wanted and the discharge (V2) of dialysis solution during this period, determine dialysis using formula L2=V2/t2 Flow quantity (L2).
7. persistence blood purification device according to claim 6, it is characterised in that
The control unit is saturating by the downside in the liquid level decline of the dialysis solution flowed out from dialysis solution measuring container (28) After analysis liquid liquid level sensor (29) is detected, dialysis solution folder (22) and dialysis solution metering electricity consumption magnet valve (26) dimension is made Hold in " opening " state, until the liquid level of the dialysis solution rises and detected by downside dialysis solution liquid level sensor (29) again To.
8. the persistence blood purification device according to any one of claim 5～7, it is characterised in that
The control unit compares the downside dialysis solution when the liquid level of the dialysis solution when making dialysis liquid pump (23) work is located at In the case that the state of liquid level sensor (29) position on the lower continue for certain hour, output alarm produces signal, and defeated Go out the stop signal of dialysis liquid pump (23).
9. the persistence blood purification device according to any one of claim 1～8, it is characterised in that
Possess for determining the capacity formula metering units of waste liquid flow off and on and controlling the control of the capacity formula metering units Portion,
Waste liquid stream (40) between (42) and the waste drains pump (43) are pressed from both sides in the waste liquid and is connected with waste liquid branch flow passage (45), based on the waste liquid branch flow passage (45) is configured with waste liquid successively as the capacity formula metering units by determining waste liquid flow Amount is with electromagnetic valve (46), upside waste liquid liquid level sensor (47), positioned at the dialysis solution tap than the blood purification (12) The waste liquid measuring container (48) of low position and downside waste liquid liquid level sensor (49),
The control unit is repeated following control：
By in the state of the waste drains pump (43) rotation is made making waste liquid metering electromagnetic valve (46) to become " opening " shape State simultaneously makes waste liquid folder (42) become "Off" state, waste liquid is flowed in waste liquid measuring container (48),
Flow into waste liquid measuring container (48) waste liquid liquid level rise and by upside waste liquid liquid level sensor (47) After detecting, make waste liquid folder (42) become " opening " state, thus make the waste liquid Jing in waste liquid measuring container (48) Discharged from the outlet (41) by waste liquid branch flow passage (45) and the waste liquid stream (40),
Make waste liquid folder (42) become "Off" state with separating predetermined time interval；
In addition, the control unit always according to from flow into waste liquid measuring container (48) waste liquid liquid level by the downside waste liquid Liquid level sensor (49) has detected required inflow till being detected by upside waste liquid liquid level sensor (47) The influx (V3) of time (t3) and waste liquid during this period, determines waste liquid flow (L3) using formula L3=V3/t3.
10. the persistence blood purification device according to claim 4 or 8, it is characterised in that
When the control unit exports the stop signal that alarm produces signal and pump, stop the blood pump (11).
The 11. persistence blood purification devices according to any one of claim 1～10, it is characterised in that
The control unit controls dialysis liquid pump (23), the fluid infusion pump (33) and respective turn of the waste drains pump (43) Speed so that the dialysate flow for calculating with separating predetermined time interval, fluid infusion flow and waste liquid flow with it is respective Setting value is consistent.
A kind of 12. persistence blood purification devices, derive blood from the vein of patient or tremulous pulse, and by the blood after purification The vein of patient is fed back to,
The persistence blood purification device is characterised by,
Possess：Blood extracorporeal circulation loop, the blood extracorporeal circulation loop are from the vein or tremulous pulse of patient to vein Closed circuit, and it is configured with the blood purification being made up of transfusion filterses；Fluid infusion stream, the fluid infusion stream are used for towards will be by The blood purification purification feeds the fluid infusion comprising body fluid components by the blood after blood purification purification；Waste liquid Stream, the waste liquid stream for by after blood purification waste liquid discharge；Based on the capacity formula for determining fluid infusion flow off and on Amount unit；And control the control unit of the capacity formula metering units,
There are blood pump and the blood purification in the blood extracorporeal circulation loop configuration,
Fluid infusion bottle, fluid infusion folder and fluid infusion pump is configured with successively in the fluid infusion stream, and the fluid infusion stream is in the fluid infusion pump The downstream of allocation position be connected to the blood extracorporeal circulation loop,
The fluid infusion stream between fluid infusion folder and the fluid infusion pump is connected with fluid infusion branch flow passage, in the fluid infusion branch Stream is configured with fluid infusion metering electromagnetic valve, upside fluid infusion liquid successively as the capacity formula metering units for determining fluid infusion flow Level sensor, positioned at the fluid infusion measuring container and downside fluid infusion liquid level sensor of the position lower than the fluid infusion bottle,
Outlet, waste liquid folder and waste drains pump is configured with successively in the waste liquid stream, and the waste liquid stream is in the waste drains pump The upstream side of allocation position be connected to the blood purification,
The control unit separates the opening and closing that predetermined time interval controls the fluid infusion metering electromagnetic valve and fluid infusion folder, Fluid infusion stream is calculated based on the detection information from the upside fluid infusion liquid level sensor and the downside fluid infusion liquid level sensor Amount, also,
When the fluid infusion pump work is made, the liquid level of fluid infusion is located at and compares downside fluid infusion liquid level sensor position on the lower State continue for certain hour in the case of, output alarm produce signal.
A kind of 13. persistence blood purification devices, derive blood from the vein of patient or tremulous pulse, and by the blood after purification The vein of patient is fed back to,
The persistence blood purification device is characterised by,
Possess：Blood extracorporeal circulation loop, the blood extracorporeal circulation loop are from the vein or tremulous pulse of patient to vein Closed circuit, and it is configured with the blood purification being made up of hemodialyzer；Dialysate circuit, the dialysate circuit for The blood purification imports dialysis solution；Waste liquid stream, the waste liquid stream for by after blood purification waste liquid discharge；For The capacity formula metering units of dialysate flow are determined off and on；And control the control unit of the capacity formula metering units,
There are blood pump and the blood purification in the blood extracorporeal circulation loop configuration,
Dialysis solution bottle, dialysis solution folder and liquid pump of dialysing is configured with successively in the dialysate circuit, and the dialysate circuit exists The downstream of the allocation position of the dialysis liquid pump is connected to the dialysis solution hand-hole of the blood purification,
Press from both sides in the dialysis solution and the dialysate circuit between liquid pump of dialysing is connected with dialysis solution branch flow passage, at this Dialysis solution branch flow passage is configured with dialysis solution metering electricity consumption successively as the capacity formula metering units for determining dialysate flow Magnet valve, upside dialysis solution liquid level sensor, the dialysis solution measuring container positioned at the position lower than the dialysis solution bottle and downside Dialysis solution liquid level sensor,
Outlet, waste liquid folder and waste drains pump is configured with successively in the waste liquid stream, and the waste liquid stream is in the waste drains pump The upstream side of allocation position be connected to the dialysis solution tap of the blood purification,
The control unit separates predetermined time interval and controls dialysis solution metering electricity consumption magnet valve and dialysis solution folder Opening and closing, based on the detection information meter from the upside dialysis solution liquid level sensor and the downside dialysis solution liquid level sensor Dialysate flow is calculated, also,
The downside dialysis solution liquid level sensor is compared on the lower when the liquid level of the dialysis solution when the dialysis solution pump work is made is located at In the case that the state of the position of side continue for certain hour, output alarm produces signal.
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