CN106512889A - Clindamycin hydrochloride reaction container - Google Patents
Clindamycin hydrochloride reaction container Download PDFInfo
- Publication number
- CN106512889A CN106512889A CN201510587037.3A CN201510587037A CN106512889A CN 106512889 A CN106512889 A CN 106512889A CN 201510587037 A CN201510587037 A CN 201510587037A CN 106512889 A CN106512889 A CN 106512889A
- Authority
- CN
- China
- Prior art keywords
- storage tank
- retort
- clindamycin hydrochloride
- material inlet
- material storage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention relates to a clindamycin hydrochloride reaction container which comprises a reaction tank, a left material storage tank, a right material storage tank and a heat preservation shell, wherein the heat preservation shell is connected with the reaction tank through ear type supports; the left material storage tank, the right material storage tank and the reaction tank are connected through pipelines; stop valves are arranged on the pipelines; a material inlet I is formed in the upper end of the left material storage tank; a liquidometer is arranged at the right end of the material inlet and is connected with a pressure probe; the pressure probe internally extends into the left material storage tank; a stirrer is arranged on the reaction tank and is connected with a conical vortex generator through a connection rod; a supporting block is arranged below the conical vortex device; the supporting block is fixed on the inner wall of an end socket of the reaction tank through a vertical column; a reactant outlet is formed in the bottom end of the reaction tank. By the respective arrangement of the left and right material storage tanks and additional arrangement of the liquidometer in the material storage tank, regulation of a volume ratio of reaction raw materials is facilitated; solutions conditioned according to a certain ratio are mixed and flow into the reaction tank for full reaction.
Description
Technical field
The present invention relates to medication chemistry consersion unit technical field, specifically Clindamycin Hydrochloride is anti-
Answer container.
Background technology
The derivant of clindamycin hydrochloride palmitate system clindamycin, in vitro without antibacterial activity, in body
Interior Jing esterase hydrolyzeds form clindamycin and play antibacterial activity, and its crude drug is recorded in national drug mark
Quasi- new drug is become a full member standard, but uncharged dispersible tablet and dry suspension.Clindamycin Hydrochloride and hydrochloric acid crin
The document report of mycin phosphate ester analysis is more, but the document report of clindamycin hydrochloride palmitate analysis
Less, its dispersible tablet and dry suspension dissolution test method domestic and foreign literature have no report.State food
Drug Administration's clindamycin palmitate hydrochloride dispersion tablet and dry suspension standard (trying)
In non-row dissolution test item, according to the requirement of Chinese Pharmacopoeia two annex of version in 2010, dispersible tablet
Dissolution test need to be carried out with dry suspension.The Palmic acid of Clindamycin Hydrochloride and long aliphatic chain into after ester,
There is large change in chemical property, have studied clindamycin palmitate hydrochloride dispersion tablet and dry-mixed herein
The dissolution medium of suspension, establishes the dissolution of its dispersible tablet of high effective liquid chromatography for measuring and dry suspension
Degree, and Method validation has been carried out, it is that Chinese Pharmacopoeia revises and enlarges clindamycin palmitate hydrochloride dispersion tablet
Scientific basis is provided with dry suspension dissolution test method；Existing Clindamycin Hydrochloride synthesis technique sets
It is standby more to fall behind, need to be improved.
Based on above reason, Clindamycin Hydrochloride reaction vessel is needed to be devised, by reaction
The outside of tank arranges lagging casing, when can guarantee that synthetic reaction is carried out, retort temperature it is constant；It is logical
Cross and be respectively provided with left and right storage tank and install liquidometer in storage tank additional, conveniently carry out the appearance of reaction raw materials
Amount ratio is allocated, and solution deployed according to a certain percentage is mixed, and is flowed in retort, is being stirred
In the presence of mixing device, reaction is sufficiently mixed, by reactant outlet into lower one after the completion of reaction
Operation, i.e. Clindamycin Hydrochloride reaction vessel.
The content of the invention
The present invention is in order to overcome deficiency of the prior art, there is provided Clindamycin Hydrochloride reaction vessel.
The present invention is to be achieved through the following technical solutions：
Clindamycin Hydrochloride reaction vessel, it is outer including retort, left storage tank, right storage tank and insulation
Shell；By hanging support connection, the hanging support and reaction between the lagging casing and retort
Backing plate is lined between tank, is fastened by bolts device detachable between the hanging support and lagging casing
Connection；The left storage tank, right storage tank and retort are connected by pipeline, be provided with and cut on pipeline
Only valve；The left storage tank upper end is provided with material inlet one, and material inlet right-hand member is provided with liquidometer,
Liquidometer is connected with pressure probe, is stretched into inside left storage tank in the pressure probe；The right storing
Tank upper end is provided with material inlet two, is provided with liquidometer on the left of material inlet two, and liquidometer is connected with
Pressure probe；Blender is provided with the retort, and blender is connected with taper whirlpool by connecting rod
Device, is provided with support block below taper whirlpool device, the support block is fixed on retort by column
On end socket inwall；The bottom of retort is provided with reactant outlet；The lagging casing bottom is provided with
Supporting leg, is connected with base plate below supporting leg.
Further, the blender adopts frequency modulation motor, arranges timing rotating by controller,
Drive taper whirlpool device to press the forward and reverse rotation of certain frequency, increase the turbulence level of retort materials inside,
Reaction process is improved fully.
Further, the taper whirlpool device and connecting rod carry out reinforcement of weld by gusset, prevent just
The destruction of linkage connector and taper whirlpool device is caused when rotating backward because moment of torsion is excessive.
Further, the support block upper surface is provided with ball recess, the taper whirlpool device and
Bracer is point contact, while increasing taper whirlpool device stability, reduces frictional force.
Further, the lagging casing and retort are easy to by hanging support for being detachably connected
Assembly and disassembly；It is also convenient for carrying out the cleaning of the impurity in lagging casing.
Further, the material inlet one, material inlet two and reactant outlet is tubular type flange
Structure, is easy to the connection with upper and lower process equipment.
Further, the supporting leg is made up of I-steel, with very high stability, the supporting leg and
Base plate is to be welded to connect.
Compared with prior art, the invention has the beneficial effects as follows：The present invention it is reasonable in design, by
The outside of retort arranges lagging casing, when can guarantee that synthetic reaction is carried out, retort temperature it is constant；
By being respectively provided with left and right storage tank and installing liquidometer additional in storage tank, reaction raw materials are conveniently carried out
Capacity ratio is allocated, and solution deployed according to a certain percentage is mixed, and is flowed in retort,
In the presence of agitating device, reaction is sufficiently mixed, after the completion of reaction, enters next by reactant outlet
Procedure.
Description of the drawings
Fig. 1 is the structural representation of the present invention；
In figure：1st, retort, 2, lagging casing, 3, left storage tank, 4, right storage tank, 5, stir
Mix machine, 6, connecting rod, 7, taper whirlpool device, 8, support block, 9, column, 10, reactant outlet, 11,
Stop valve, 12, material inlet one, 13, liquidometer, 14, pressure probe, 15, material inlet two,
16th, hanging support, 17, backing plate, 18, bolt clamp device, 19, supporting leg, 20, base plate.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, below in conjunction with accompanying drawing
And embodiment, the present invention will be described in further detail.It should be appreciated that described herein concrete
Embodiment only to explain the present invention, is not intended to limit the present invention.
Fig. 1 is referred to, Fig. 1 is the structural representation of the present invention.
Clindamycin Hydrochloride reaction vessel, including retort 1, left storage tank 3, right storage tank 4 and guarantor
Warm shell 2；Connected by hanging support 16 between the lagging casing 2 and retort 1, the ear
Be lined with backing plate 17 between formula bearing 16 and retort 1, the hanging support 16 and lagging casing 2 it
Between be fastened by bolts device 18 and be detachably connected；The left storage tank 3, right storage tank 4 and reaction
Tank 1 is connected by pipeline, is provided with stop valve 11 on pipeline；3 upper end of left storage tank is provided with
Material inlet 1, one 12 right-hand member of material inlet are provided with liquidometer 13, and liquidometer 13 is connected with pressure
Power probe 14, stretches into inside left storage tank 3 in the pressure probe 14；4 upper end of right storage tank
Material inlet 2 15 is provided with, liquidometer 13 on the left of material inlet 2 15, is provided with, liquidometer 13 connects
It is connected to pressure probe 14；Blender 5 is provided with the retort 1, and blender 5 passes through connecting rod 6
Taper whirlpool device 7 is connected with, support block 8 below taper whirlpool device 7, is provided with, the support block 8 is led to
Cross column 9 to be fixed on the end socket inwall of retort 1；The bottom of retort 1 is provided with reactant and goes out
Mouth 10；2 bottom of the lagging casing is provided with supporting leg 19, is connected with base plate 20 below supporting leg 19；
The blender 5 adopts frequency modulation motor, arranges timing rotating by controller, drives taper whirlpool
Device 7 presses the forward and reverse rotation of certain frequency, increases the turbulence level of 1 materials inside of retort, fully carries
High reaction process；The taper whirlpool device 7 and connecting rod 6 carry out reinforcement of weld by gusset, prevent
The destruction of 6 joint of connecting rod and taper whirlpool device 7 is caused during forward and reverse rotation because moment of torsion is excessive；Described
8 upper surface of bracer is provided with ball recess, and the taper whirlpool device 7 and support block 8 are point contact,
While increasing taper whirlpool 7 stability of device, reduce frictional force；The lagging casing 2 and retort 1
By hanging support 16 for being detachably connected, it is easy to assembly and disassembly；It is also convenient for carrying out lagging casing 2
The cleaning of interior impurity；The outlet 10 of the material inlet 1, material inlet 2 15 and reactant is equal
For tubular type flange arrangement, it is easy to the connection with upper and lower process equipment；The supporting leg 19 is made up of I-steel,
With very high stability, the supporting leg 19 and base plate 20 are for being welded to connect.
Used as a preferred embodiment of the invention, reactant A is entered in left storage tank 3, is carried out dense
Degree allotment；Reactant B is entered in right storage tank 4, carries out concentration allotment；Reactant A and B allotments
After the completion of open stop valve 11 flow into retort in reacted；Blender 5 adopts frequency modulation motor, leads to
Cross controller and timing rotating is set, drive taper whirlpool device 7 to press the forward and reverse rotation of certain frequency, increase
Plus the turbulence level of 1 materials inside of retort, fully improve reaction process；The present invention is reasonable in design,
Operate relatively simple convenience, it is adaptable in the reaction process of Clindamycin Hydrochloride synthesis technique.
The foregoing is only presently preferred embodiments of the present invention, not to limit the present invention, it is all
Any modification, equivalent and improvement for being made within the spirit and principles in the present invention etc., all should include
Within protection scope of the present invention.
Claims (7)
1. Clindamycin Hydrochloride reaction vessel, including retort (1), left storage tank (3), right storage
Batch can (4) and lagging casing (2)；It is characterized in that：Lagging casing (2) and retort (1)
Between by hanging support (16) connect, be lined between hanging support (16) and retort (1)
Backing plate (17), is fastened by bolts device (18) removable between hanging support (16) and lagging casing (2)
Unload connection；Left storage tank (3), right storage tank (4) and retort (1) are connected by pipeline, on pipeline
It is provided with stop valve (11)；Left storage tank (3) upper end is provided with material inlet one (12), material inlet
One (12) right-hand member is provided with liquidometer (13), and liquidometer (13) is connected with pressure probe (14), and the pressure is visited
It is internal that left storage tank (3) is stretched in head (14)；Right storage tank (4) upper end is provided with material inlet two
(15) liquidometer (13), is provided with the left of material inlet two (15), and liquidometer (13) is connected with pressure spy
Head (14)；Blender (5) is provided with retort (1), and blender (5) passes through connecting rod
(6) taper whirlpool device (7) is connected with, support block (8) below taper whirlpool device (7), is provided with,
Described support block (8) are fixed on the end socket inwall of retort (1) by column (9)；Retort
(1) bottom is provided with reactant outlet (10)；Lagging casing (2) bottom is provided with supporting leg (19),
Base plate (20) is connected with below lower limb (19).
2. Clindamycin Hydrochloride reaction vessel according to claim 1, it is characterised in that：It is described
Blender (5) adopts frequency modulation motor, arranges timing rotating by controller, drives taper whirlpool device (7)
By the forward and reverse rotation of certain frequency.
3. Clindamycin Hydrochloride reaction vessel according to claim 1, it is characterised in that：It is described
Taper whirlpool device (7) and connecting rod (6) carry out reinforcement of weld by gusset.
4. Clindamycin Hydrochloride reaction vessel according to claim 1, it is characterised in that：It is described
Support block (8) upper surface is provided with ball recess, taper whirlpool device (7) and support block (8)
For a contact.
5. Clindamycin Hydrochloride reaction vessel according to claim 1, it is characterised in that：It is described
Lagging casing (2) and retort (1) are to be detachably connected by hanging support (16).
6. Clindamycin Hydrochloride reaction vessel according to claim 1, it is characterised in that：It is described
Material inlet one (12), material inlet two (15) and reactant outlet (10) are tubular type flange
Structure.
7. Clindamycin Hydrochloride reaction vessel according to claim 1, it is characterised in that：It is described
Supporting leg (19) is made up of I-steel, and supporting leg (19) and base plate (20) are to be welded to connect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510587037.3A CN106512889A (en) | 2015-09-15 | 2015-09-15 | Clindamycin hydrochloride reaction container |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510587037.3A CN106512889A (en) | 2015-09-15 | 2015-09-15 | Clindamycin hydrochloride reaction container |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106512889A true CN106512889A (en) | 2017-03-22 |
Family
ID=58348655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510587037.3A Pending CN106512889A (en) | 2015-09-15 | 2015-09-15 | Clindamycin hydrochloride reaction container |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106512889A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114632490A (en) * | 2022-02-28 | 2022-06-17 | 昆山市冠宝化学有限公司 | Polyurethane adhesive preparation device and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008154666A1 (en) * | 2007-06-21 | 2008-12-24 | Lenzing Aktiengesellschaft | Thin film treatment apparatus |
| CN102886238A (en) * | 2012-10-24 | 2013-01-23 | 沈阳创达技术交易市场有限公司 | Reaction kettle with agitating paddle with improved structure |
| CN203235628U (en) * | 2013-05-07 | 2013-10-16 | 宿迁绿友光电科技有限公司 | Novel stirring head of glue filling machine |
| CN203829954U (en) * | 2014-05-09 | 2014-09-17 | 宁波嘉鸿新材料科技有限公司 | Stirrer |
| CN104176708A (en) * | 2014-08-25 | 2014-12-03 | 上海科琳宝环境科技有限公司 | Unpowered pressurized chlorine dioxide automatic-generation mixing sterilizing device |
| CN204147864U (en) * | 2014-08-29 | 2015-02-11 | 赣县宏茂锡业焊料有限公司 | For the production of the combination type heating furnace of solder stick |
-
2015
- 2015-09-15 CN CN201510587037.3A patent/CN106512889A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008154666A1 (en) * | 2007-06-21 | 2008-12-24 | Lenzing Aktiengesellschaft | Thin film treatment apparatus |
| CN102886238A (en) * | 2012-10-24 | 2013-01-23 | 沈阳创达技术交易市场有限公司 | Reaction kettle with agitating paddle with improved structure |
| CN203235628U (en) * | 2013-05-07 | 2013-10-16 | 宿迁绿友光电科技有限公司 | Novel stirring head of glue filling machine |
| CN203829954U (en) * | 2014-05-09 | 2014-09-17 | 宁波嘉鸿新材料科技有限公司 | Stirrer |
| CN104176708A (en) * | 2014-08-25 | 2014-12-03 | 上海科琳宝环境科技有限公司 | Unpowered pressurized chlorine dioxide automatic-generation mixing sterilizing device |
| CN204147864U (en) * | 2014-08-29 | 2015-02-11 | 赣县宏茂锡业焊料有限公司 | For the production of the combination type heating furnace of solder stick |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114632490A (en) * | 2022-02-28 | 2022-06-17 | 昆山市冠宝化学有限公司 | Polyurethane adhesive preparation device and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN209254633U (en) | Compounding device | |
| CN109126546A (en) | A kind of pharmacy agitating device | |
| CN106512889A (en) | Clindamycin hydrochloride reaction container | |
| CN109554293A (en) | A kind of Biofermentation system | |
| CN204564144U (en) | A kind of reactor | |
| CN207581811U (en) | A kind of defoaming fermentation tank | |
| CN205586899U (en) | Medicine agitating unit | |
| CN209537500U (en) | Enzymolysis device is used in a kind of production of heparin sodium | |
| CN209173918U (en) | A kind of gas liquid reaction kettle device | |
| CN104107655A (en) | Stirring machine | |
| CN109499504A (en) | A kind of horizontal degassing reaction kettle | |
| CN105498580B (en) | A kind of quick mixing agitator of heated type biliquid | |
| CN109126603A (en) | A kind of efficient pharmacy agitating device | |
| CN205517360U (en) | Add hot type biliquid body flash mixed agitator | |
| CN105457528B (en) | A kind of quick mixing agitator | |
| CN209307348U (en) | A kind of novel multi-layer fermentor | |
| CN209438579U (en) | A kind of horizontal degassing reaction kettle | |
| CN208161507U (en) | A kind of compounding medicine tank with automatic defoaming device | |
| CN209173935U (en) | A kind of liquid sodium silicate production continous way Liquid-phase reactor | |
| CN207769700U (en) | Magnetic stirring apparatus for low sticky degree solution | |
| CN206385134U (en) | A kind of high-efficiency stirring formula seeding tank | |
| CN207435429U (en) | A kind of ketoglutaric acid production fermentation tank | |
| CN212931114U (en) | Traditional chinese medicine preparation fluidized bed heat transfer device | |
| CN208465876U (en) | A kind of two-phase drug response extraction equipment | |
| CN206590955U (en) | A kind of upflow type anaerobic sewage treatment pot |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170322 |