CN106511681A - Soft capsule for treating cardiovascular and cerebrovascular diseases - Google Patents
Soft capsule for treating cardiovascular and cerebrovascular diseases Download PDFInfo
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- CN106511681A CN106511681A CN201611232119.7A CN201611232119A CN106511681A CN 106511681 A CN106511681 A CN 106511681A CN 201611232119 A CN201611232119 A CN 201611232119A CN 106511681 A CN106511681 A CN 106511681A
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- soft capsule
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- cerebrovascular disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a soft capsule for treating cardiovascular and cerebrovascular diseases. The soft capsule consists of the following ingredients in parts by weight: 1-5 parts of a ginkgo biloba extract, 100-300 parts of palm oil, 0.1-2 parts of vitamin B12, 1-3 parts of an aloe extract and 100-200 parts of soybean oil. The soft capsule for treating the cardiovascular and cerebrovascular diseases provided by the invention, which selects the ginkgo biloba extract and the aloe extract as two major efficacy ingredients therein, can take good effects of softening blood vessels and promoting reducing of blood lipid; and the soft capsule can obviously improve symptoms in patients with hypertension and hyperlipidemia, so that people's life quality can be improved.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, more particularly to a kind of ginkgo leaf soft capsule and its preparation side
Method, belongs to the modernization technology of preparing of Chinese medicine compound preparation.
Background technology
Folium Ginkgo, also known as moth leaf, duck bottom sediment, are Ginkgoaceae plant Ginkgo bilobaGinkgo biloba L.Dried leaves.Autumn
Harvest when Ji Yeshang is green, be dried in time.The many fold of Folium Ginkgo are broken, and complete person is in fan-shaped, long 3～12cm, wide 5～15cm.
Yellow green or sundown, in irregular wavy bending, some centres are recessed, and deep person up to leaf length 4/5 for upper limb.Folium Ginkgo
Body is light, feeble QI, mildly bitter flavor.GUIXIN, lung meridian.Indication：Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency；Coronary disease
Disease, angina pectoriss, hyperlipidemia.
With Chinese society progress, the dietetic nutrition structure of increasing people there occurs huge change, especially
It is that the intake of oils and fatss is significantly increased.This causes people with advancing age, based on the natural causes such as diet institute
Caused hyperlipidemia, hyperpietic are more and more, and what this was serious threatens the life and health of people.
Show according to Ministry of Public Health statistical data in 2010：The Chinese Patients with Cardiovascular/Cerebrovascular Diseases First episode age 1/3 was at 60 years old
Hereinafter, sickness rate is up to 13.6%, and cardiovascular and cerebrovascular disease has the trend of rejuvenation.And, there is disease in the morbidity of certain patient
Shape, mortality rate are high, and the time of rescue is also very urgent.
How one kind is prepared using existing Chinese crude drug to be conveniently applied in daily life, prevent and treat cardiovascular and cerebrovascular vessel
Seizure of disease, reduces hypertension, hyperlipidemia for the threat of people's life and health, into increasingly urgent problems.
The content of the invention
It is an object of the invention to overcoming, cardiovascular and cerebrovascular disease in prior art is big for the health threat of people, injury is tight
A kind of problem of weight, there is provided soft capsule for cardiovascular and cerebrovascular disease.The soft capsule of the present invention is mainly containing Folium Ginkgo drug effect
The soft capsule of composition, has significant curative effect for cardiovascular and cerebrovascular disease is improved, and can reduce hypertension, hyperlipidemia for human body
The harm of health.
In order to realize foregoing invention purpose, the invention provides technical scheme below：
A kind of soft capsule for treating cardiovascular and cerebrovascular disease, including weight portion following component：Ginkgo Biloba Extract 1-5 part, palm fibre
Palmitic acid oil 100-300 parts, vitamin B120.1-2 parts, Aloe extract 1-3 parts, soybean oil 100-200 parts.
The soft capsule for cardiovascular and cerebrovascular disease of the present invention, with low cost, the characteristics of effect is good, easily can enter
Row is carried with, it is adaptable to the disease such as various types of hypertension, hyperlipidemia, substantially reduces cardiovascular and cerebrovascular disease for human body is strong
The threat of health.
Further, the soft capsule for being used to treat cardiovascular and cerebrovascular disease as above, including weight portion following component：Semen Ginkgo
Leaf extract 2-4 parts, Petiolus Trachycarpi oil 120-280 parts, vitamin B120.2-1.5 parts, Aloe extract 1-3 parts, soybean oil 120-
200 parts.
Further, the soft capsule for being used to treat cardiovascular and cerebrovascular disease as above, including weight portion following component：Semen Ginkgo
Leaf extract 2-4 parts, Petiolus Trachycarpi oil 170-240 parts, vitamin B120.2-1 parts, Aloe extract 1-3 parts, soybean oil 140-180
Part.
Further, in the Aloe extract barbaloin content 0.5%-5wt%.
Further, there is wherein customary adjuvant in the soft capsule.Such as gelatin, Sorbitol, glycerol, Propylene Glycol etc..
Further, the Ginkgo Biloba Extract is prepared by the following method and obtains：Fresh Folium Ginkgo is cleaned, 1- is used
The 20-70v% ethanol solution of 2 times of weight is extracted 1-3 time, united extraction liquid, after reclaiming ethanol, extracting solution is concentrated into 1g Semen Ginkgoes
Leaf correspondence 0.2-1g crude drugs.
Further, extracted using 30-60v% ethanol solution.
Further, in extraction process, solution is heated to 50-90 DEG C.
Further, when extracting solution is concentrated, concentrated using vacuum and low temperature, temperature control is at 60-80 DEG C.
Compared with prior art, beneficial effects of the present invention：
1. the soft capsule composition for treating cardiovascular and cerebrovascular disease of the present invention have selected Ginkgo Biloba Extract and Aloe extract
Two kinds of main active ingredient in as soft capsule, for vessel softening, promote blood fat to reduce with good effect, can
Significantly improve the symptom of hypertension, hyperlipemic patients, improve the quality of life of people.
2. Aloe extract further comprises in the soft capsule composition for treating cardiovascular and cerebrovascular disease of the present invention, for
Collaboration Folium Ginkgo improves blood fat and has good help.
3. the present invention is extracted in the method for Folium Ginkgo, and the ethanol of application is extracted, high with extraction efficiency, extracts effect
Really good the characteristics of,, rich in the active substance in Folium Ginkgo, soft capsule drug effect is more preferably for the Ginkgo Biloba Extract for preparing.
Specific embodiment
With reference to test example and specific embodiment, the present invention is described in further detail.But this should not be understood
Scope for above-mentioned theme of the invention is only limitted to below example, and all technologies realized based on present invention belong to this
The scope of invention.In the present invention, not specified percentage ratio is weight percentage.
Embodiment 1
Prepare Ginkgo Biloba Extract
Fresh Folium Ginkgo is cleaned, is extracted 3 times with the 40v% ethanol solution of 2 times of weight, 3 hours for the first time, second 2 hours,
1.5 hours for the third time, united extraction liquid, after ethanol is reclaimed in vacuum distillation, extracting solution was concentrated to dryness.
The soft capsule for the treatment of cardiovascular and cerebrovascular disease
The soft capsule for the treatment of cardiovascular and cerebrovascular disease, including weight portion following component：3 parts of Ginkgo Biloba Extract, 200 parts of Petiolus Trachycarpi oil,
Vitamin B120.4 part, 2 parts of Aloe extract, 160 parts of soybean oil.Wherein, Aloe extract is the Aloe extract of outsourcing, reed
Content >=1.2% of luxuriant growth glycosides（Weight）.
Embodiment 2
The soft capsule for the treatment of cardiovascular and cerebrovascular disease
The soft capsule for the treatment of cardiovascular and cerebrovascular disease, including weight portion following component：5 parts of Ginkgo Biloba Extract, 220 parts of Petiolus Trachycarpi oil,
Vitamin B121 part, 1 part of Aloe extract, 140 parts of soybean oil.Ginkgo Biloba Extract, Aloe extract are originated with embodiment 1.
Embodiment 3
The soft capsule for the treatment of cardiovascular and cerebrovascular disease
The soft capsule for the treatment of cardiovascular and cerebrovascular disease, including weight portion following component：4 parts of Ginkgo Biloba Extract, 300 parts of Petiolus Trachycarpi oil,
Vitamin B122 parts, 3 parts of Aloe extract, 180 parts of soybean oil, 35 parts of gelatin, 10 parts of glycerol.Ginkgo Biloba Extract, Aloe carry
Take thing to originate with embodiment 1.
Embodiment 4
Prepare Ginkgo Biloba Extract
Fresh Folium Ginkgo is cleaned, is extracted 3 times with the 70v% ethanol solution of 1.8 times of weight, 4 hours for the first time, 2 is little for the second time
When, extracting solution, after ethanol is reclaimed in vacuum distillation, is concentrated into 1g Folium Ginkgos correspondence 0.8g former by third time 1 hour, united extraction liquid
Medical material.
The soft capsule for the treatment of cardiovascular and cerebrovascular disease
Weight portion following component mix homogeneously is prepared into into soft capsule：3 parts of Ginkgo Biloba Extract, 270 parts of Petiolus Trachycarpi oil, vitamin
B121.5 parts, 2 parts of Aloe extract, 140 parts of soybean oil, 35 parts of gelatin, 10 parts of glycerol.Aloe extract is originated with embodiment 1.
Embodiment 5
The soft capsule for the treatment of cardiovascular and cerebrovascular disease
Weight portion following component mix homogeneously is prepared into into soft capsule：2 parts of Ginkgo Biloba Extract, 240 parts of Petiolus Trachycarpi oil, vitamin
B121 part, 1 part of Aloe extract, 190 parts of soybean oil, 25 parts of gelatin, 20 parts of glycerol.Ginkgo Biloba Extract source embodiment 4, reed
Luxuriant growth extract is originated with embodiment 1.
Embodiment 6
The soft capsule for the treatment of cardiovascular and cerebrovascular disease
Weight portion following component mix homogeneously is prepared into into soft capsule：2 parts of Ginkgo Biloba Extract, 220 parts of Petiolus Trachycarpi oil, vitamin
B121.2 parts, 2 parts of Aloe extract, 210 parts of soybean oil, 10 parts of Propylene Glycol, 20 parts of glycerol.Ginkgo Biloba Extract source embodiment
4th, Aloe extract is originated with embodiment 1.
Claims (9)
1. a kind of soft capsule for treating cardiovascular and cerebrovascular disease, including weight portion following component：Ginkgo Biloba Extract 1-5 part,
Petiolus Trachycarpi oil 100-300 parts, vitamin B120.1-2 parts, Aloe extract 1-3 parts, soybean oil 100-200 parts.
2. be used for as claimed in claim 1 treating the soft capsule of cardiovascular and cerebrovascular disease, it is characterised in that including below weight portion into
Point：Ginkgo Biloba Extract 2-4 part, Petiolus Trachycarpi oil 120-280 parts, vitamin B120.2-1.5 parts, Aloe extract 1-3 parts, Semen sojae atricolor
Oily 120-200 parts.
3. be used for as claimed in claim 1 treating the soft capsule of cardiovascular and cerebrovascular disease, it is characterised in that including below weight portion into
Point：Ginkgo Biloba Extract 2-4 part, Petiolus Trachycarpi oil 170-240 parts, vitamin B120.2-1 parts, Aloe extract 1-3 parts, soybean oil
140-180 parts.
4. it is used for as claimed in claim 1 treating the soft capsule of cardiovascular and cerebrovascular disease, it is characterised in that in the Aloe extract
Content 0.5%-5wt% of barbaloin.
5. it is used for as claimed in claim 1 treating the soft capsule of cardiovascular and cerebrovascular disease, it is characterised in that in the soft capsule also
There is wherein customary adjuvant.
6. it is used for as claimed in claim 1 treating the soft capsule of cardiovascular and cerebrovascular disease, it is characterised in that the Ginkgo Biloba Extract
It is prepared by the following method and obtains：Fresh Folium Ginkgo is cleaned, and 1-3 is extracted with the 20-70v% ethanol solution of 1-2 times of weight
Secondary, extracting solution, after reclaiming ethanol, is concentrated into 1g Folium Ginkgos correspondence 0.2-1g crude drugs by united extraction liquid.
7. it is used for as claimed in claim 6 treating the soft capsule of cardiovascular and cerebrovascular disease, it is characterised in that using 30-60v% ethanol
Solution is extracted.
8. it is used for as claimed in claim 6 treating the soft capsule of cardiovascular and cerebrovascular disease, it is characterised in that in extraction process, solution adds
Heat is to 50-90 DEG C.
9. be used for as claimed in claim 6 treating the soft capsule of cardiovascular and cerebrovascular disease, it is characterised in that extracting solution concentration when
Wait, concentrated using vacuum and low temperature, temperature control is at 60-80 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611232119.7A CN106511681A (en) | 2016-12-28 | 2016-12-28 | Soft capsule for treating cardiovascular and cerebrovascular diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611232119.7A CN106511681A (en) | 2016-12-28 | 2016-12-28 | Soft capsule for treating cardiovascular and cerebrovascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106511681A true CN106511681A (en) | 2017-03-22 |
Family
ID=58337939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611232119.7A Withdrawn CN106511681A (en) | 2016-12-28 | 2016-12-28 | Soft capsule for treating cardiovascular and cerebrovascular diseases |
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| Country | Link |
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| CN (1) | CN106511681A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2666597C1 (en) * | 2018-01-17 | 2018-09-11 | Александр Александрович Кролевец | Method for producing nanocapules of dry aloe extract |
-
2016
- 2016-12-28 CN CN201611232119.7A patent/CN106511681A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2666597C1 (en) * | 2018-01-17 | 2018-09-11 | Александр Александрович Кролевец | Method for producing nanocapules of dry aloe extract |
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| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170322 |
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| WW01 | Invention patent application withdrawn after publication |