CN106511430A - Digestive and stomachics tablet - Google Patents
Digestive and stomachics tablet Download PDFInfo
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- CN106511430A CN106511430A CN201710012742.XA CN201710012742A CN106511430A CN 106511430 A CN106511430 A CN 106511430A CN 201710012742 A CN201710012742 A CN 201710012742A CN 106511430 A CN106511430 A CN 106511430A
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- digestion
- balloonflower root
- stem cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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- Alternative & Traditional Medicine (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a digestive and stomachics tablet. The digestive and stomachics tablet is prepared from, by weight, 10-20 parts of dry powder of stem cells of platycodon grandiflorum, and 30-40 parts of water. Compared with the prior art, the digestive and stomachics tablet has the advantages that merely dry powder of stem cells of platycodon grandiflorum and water are used as raw materials to be prepared into the digestive and stomachics tablet, thereby components are natural and simple; the obtained digestive and stomachics tablet is fresh and elegant in flavor, good in palatability, rich in nutrient and remarkable in digestion improvement effect; in addition, the digestive and stomachics tablet is also capable of reducing blood glucose and is wide in suitable crowd.
Description
Technical field
The invention belongs to field of health care products, and in particular to a kind of digestion-promoting stomachic.
Background technology
As the development of social economy, people's living standard are improved constantly, on market, diet kind is increasingly enriched, most
People is busy with one's work, and causes diet irregular, and Jing often eats and drinks immoderately, and does not also note personal dietetic hygiene, and love eats greasy, raw and cold, burning
The foods such as roasting class, cause indigestion, functions of intestines and stomach to die down, the indigestion such as Jing often occurs having a stomachache, suffers from diarrhoea, constipation, vomiting
Shape.For these indigestion symptoms, using promoting WeiDongLi Capsule medicine such as Domperidone, Cimetidine, method not to replace more than modern Western medicine
The medicines such as fourth, but Western medicine has many bad reactions, the stimulation to stomach is very big；Traditional chinese medicine medicament relaxes, and has no side effect, therefore centering
Medicinal material science is combined, and rational proportion becomes current research focus.
Patent application publication CN104288615A discloses a kind of digestion-promoting stomachic, is made up of the raw material of following weight portion：
Ginseng 10-16 parts, hawthorn 10-20 parts, Radix Glycyrrhizae 8-12 parts, the membrane of a chicken's gizzard 8-10 parts, six song 12-18 parts, fig 8-12 parts, radish
Sub- 10-16 parts, malt 10-20 parts, xylitol 10-16 parts, honey 10-14 parts, starch 30-50 parts, water 50-70 parts.
Patent application publication CN105497685A discloses a kind of digestion-promoting stomachic, is made up of the raw material of following weight portion：
Farina 30-40 parts, six song 8-10 parts, malt 15-25 parts, xylitol 10-12 parts, honey 10-20 parts, hawthorn 15-25
Part, Gorgon fruit 8-10 parts, nutmeg 10-12 parts, Lysimachia foenum-graecum 8-10 parts, ciliate leucas herb 5-15 parts, the membrane of a chicken's gizzard 8-12 parts, water 50-60 parts.
Although rationally compounding the effect that obtained XIAOSHI PIAN can obtain stomach strengthening and digestion promoting by plurality of Chinese in prior art,
Due to Chinese medicine to contain bitter principle, palatability is poor more；XIAOSHI PIAN containing traditional Chinese medicine ingredients also tend to by add a large amount of sweeteners come
The bitter taste of Chinese medicine itself is covered, therefore should not be eaten more, be not particularly suitable for patients with diabetes mellitus.
The content of the invention
For the above-mentioned problems in the prior art, it is an object of the invention to provide a kind of digestion-promoting stomachic, to
Only XIAOSHI PIAN is prepared by two kinds of raw materials, realize promoting digestion, drop hypoglycemic effect.
For achieving the above object, the technical solution used in the present invention is as follows：
A kind of digestion-promoting stomachic, including the raw material of following weight part ratio：Balloonflower root stem cell dry powder 10-20 parts, water 30-40
Part.
The preparation method of the balloonflower root stem cell dry powder is：Balloonflower root main root sterilization is taken, aseptic thin slice is whittled into and with high
Osmometer solution process, is transferred to inducing culture to there is cell to grow, then by explant subculture to growth medium culture 10-
20d obtains balloonflower root forming layer stem cell, Amplification Culture, ultrafiltration clone, the macromolecular mass retained with 70-90% ethanol elutions, and one
Rotary evaporation is distinguished to effluent volume without the macromolecular mass of Ultrasonic Pulverization with second half after half macromolecular mass Ultrasonic Pulverization
1/5-1/3, is pulverized and mixed after vacuum freeze drying.
Cephalo ammonia of the method for balloonflower root main root sterilization for 0.3-0.8% in the balloonflower root stem cell process for preparation of dry powder
Benzyl pre-processes 3-5h, and then aseptic water washing 20-30min, is put into sterilization 50-90s in 70% ethanol solution, aseptic water washing
4-8min.
Glucose solution of the balloonflower root stem cell process for preparation of dry powder middle and high infiltration solution for 20-40%.
The milipore filter molecular weight that ultrafiltration is used in the balloonflower root stem cell process for preparation of dry powder is 8000-12000.
In the balloonflower root stem cell process for preparation of dry powder, the temperature of rotary evaporation is 65-75 DEG C.
The inducing culture is 1/2MS culture medium+0.3-0.6mg/L NAA+1.2-1.8mg/L niacins.
The growth medium is MS culture medium+0.35-0.65mg/L6-BA+0.01-0.04mg/LNAA+90-110mg/
L citric acids.
Balloonflower root [Platycodon grandiflorum (Jacq.A.DC.)] is Campanulaceae (Campanulaceae) balloonflower root
Category herbaceos perennial root.Containing synanthrin type polysaccharide, saponin(e, flavones, deep and remote alcohol, starch, phenols, carbene, fat oil, fat
Acid, amino acid (Soviet Union, clump, paddy, it is sweet, third, egg, different bright, lysine etc.), micro- such as zinc, iron, magnesium, sodium, calcium etc., volatile oil
The compositions such as poly- scarce class, with the effect for promoting food digestion.
The present invention extracts its stem cell secretion thing for being rich in nutrient content, very by building balloonflower root stem cell culture technique
Vacuum freecing-dry is prepared into XIAOSHI PIAN into dry powder.Wherein the macromolecular of Jing Ultrasonic Pulverizations due to the physical decomposition of natural polysaccharide is in
Sweet taste, therefore without the need for additionally adding sweetener when preparing XIAOSHI PIAN.And without the macromolecular mass of Ultrasonic Pulverization due to balloonflower root starch
Presence, can play when being prepared to XIAOSHI PIAN suspension, dispersion and thick effect, eliminate the addition of suspending agent in XIAOSHI PIAN.Together
When macromolecular mass in synanthrin type polysaccharide there is the hypoglycemic effect of drop, diabetic's also edible.
Compared with prior art, beneficial effects of the present invention are：Only prepared as raw material with balloonflower root stem cell dry powder and water and disappeared
Food piece, composition are natural simple, and gained XIAOSHI PIAN is pure and fresh simple and elegant, and palatability is good, nutritious, stomach strengthening and digestion promoting effect is significant, may be used also
Blood sugar is reduced, crowd is suitable for wide.
Specific embodiment
To make those skilled in the art be better understood when technical scheme, with reference to embodiment pair
Technical solution of the present invention is described in detail.
Experimental technique used in following embodiments if no special instructions, is conventional method.
In following embodiments, material used, reagent etc., if no special instructions, commercially obtain.
1. the preparation of balloonflower root stem cell dry powder
Embodiment 1
Balloonflower root main root is taken in 0.3% cefalexin pretreatment 3h, then aseptic water washing 20min, is put into 70% second
Sterilization 50s in alcoholic solution, aseptic water washing 4min sterilizations, are whittled into aseptic thin slice and the glucose solution with 20% is processed,
Inducing culture is transferred to there is cell to grow, explant subculture is obtained into balloonflower root forming layer to growth medium culture 10d then
Stem cell, Amplification Culture, with the milipore filter ultrafiltration clone that molecular weight is 8000, the macromolecular retained with 70% ethanol elution
Group, after half macromolecular mass Ultrasonic Pulverization with second half without the macromolecular mass of Ultrasonic Pulverization respectively in 65 DEG C of rotary evaporations to washing
The 1/5 of de- liquid product, is pulverized and mixed after vacuum freeze drying.Inducing culture used in which be 1/2MS culture mediums+
0.3mg/LNAA+1.2mg/L niacins, growth medium are MS culture medium+0.35mg/L6-BA+0.01mg/LNAA+90mg/L
Citric acid.
Embodiment 2
Balloonflower root main root is taken in 0.55% cefalexin pretreatment 4h, then aseptic water washing 25min, is put into 70% second
Sterilization 70s in alcoholic solution, aseptic water washing 6min sterilizations, are whittled into aseptic thin slice and the glucose solution with 30% is processed,
Inducing culture is transferred to there is cell to grow, explant subculture is obtained into balloonflower root forming layer to growth medium culture 15d then
Stem cell, Amplification Culture, with the milipore filter ultrafiltration clone that molecular weight is 10000, the macromolecular retained with 80% ethanol elution
Group, after half macromolecular mass Ultrasonic Pulverization with second half without the macromolecular mass of Ultrasonic Pulverization respectively in 70 DEG C of rotary evaporations to washing
The 1/4 of de- liquid product, is pulverized and mixed after vacuum freeze drying.Inducing culture used in which be 1/2MS culture mediums+
0.45mg/L NAA+1.5mg/L niacins, growth medium are MS culture medium+0.5mg/L6-BA+0.025mg/LNAA+
100mg/L citric acids.
Embodiment 3
Balloonflower root main root is taken in 0.8% cefalexin pretreatment 5h, then aseptic water washing 30min, is put into 70% second
Sterilization 90s in alcoholic solution, aseptic water washing 8min sterilizations, are whittled into aseptic thin slice and the glucose solution with 40% is processed,
Inducing culture is transferred to there is cell to grow, explant subculture is obtained into balloonflower root forming layer to growth medium culture 20d then
Stem cell, Amplification Culture, with the milipore filter ultrafiltration clone that molecular weight is 12000, the macromolecular retained with 90% ethanol elution
Group, after half macromolecular mass Ultrasonic Pulverization with second half without the macromolecular mass of Ultrasonic Pulverization respectively in 75 DEG C of rotary evaporations to washing
The 1/3 of de- liquid product, is pulverized and mixed after vacuum freeze drying.Inducing culture used in which be 1/2MS culture mediums+
0.6mg/LNAA+1.8mg/L niacins, growth medium are MS culture medium+0.65mg/L6-BA+0.04mg/LNAA+110mg/
L citric acids.
2. compressing tablet prepares digestion-promoting stomachic according to a conventional method
Embodiment 4
Formula：A kind of digestion-promoting stomachic, including the raw material of following weight part ratio：10 parts of balloonflower root stem cell dry powder, 30 parts of water.
Embodiment 5
Formula：A kind of digestion-promoting stomachic, including the raw material of following weight part ratio：15 parts of balloonflower root stem cell dry powder, 35 parts of water.
Embodiment 6
Formula：A kind of digestion-promoting stomachic, including the raw material of following weight part ratio：20 parts of balloonflower root stem cell dry powder, 40 parts of water.
3. impact of the digestion-promoting stomachic to rat gastric secretion
SD rats 24 are taken, 200～250g of body weight, male and female half and half are divided into 4 groups at random, daily gavage XIAOSHI PIAN 1 time,
Fasting 24h (can't help water) after continuous 6d, 6d administration, ligatures pylorus, and again by duodenal administration 1 time, suturing them otch.
After 2h, fu jie of taking out stitches out pricks orifice of the stomach, takes stomach, pours out gastric content, and gastric juice total amount is recorded after centrifugation.Supernatant 1mL is taken, plus it is phenol red
Indicator 1 drips, and is neutralized titration with NaOH 20mmol/L, records the NaOH liquid measures for consuming, and calculates total acidity and total acid is discharged
Amount.
Impact of 1 digestion-promoting stomachic of table to rat gastric secretion
Hydrochloric acid in gastric juice is secreted by gastric gland parietal cell, can activate propepsin, makes activated pepsin, and is
Pepsin provides suitable sour environment, can be aid digestion.Pepsin is secreted by chief cell, and important in gastric juice disappears
Change enzyme, it can carry out preliminary digestion in acid condition and decompose to protein.Hydrochloric acid in gastric juice and pepsic secretory volume are reflected
Digestive function of the stomach to food.
Digestion-promoting stomachic obtained by embodiment 4-6 is discharged to have to rat gastric secretion, hydrochloric acid in gastric juice and remarkably promotes work as known from Table 1
With.
4. impact of the digestion-promoting stomachic to hyperglycaemia mouse blood sugar level
Hyperglycaemia ICR mouse model prepares fasting 12h before injection, and free water acquisition, tail vein are noted at twice (once a day)
Firing association's dosage 90mg/kg bw streptozotocins.After recovering feeding 72h, fasting 8h, eye socket blood sampling, survey blood sugar again.Blood glucose value >=
250mg/dl is hyperglycemia model.
All mouse fasting 6h, take 10 normal mices as Normal group, and hyperglycaemia mouse is randomly divided into 3 groups, per group
10.All its mouse orals pour into Glucose Liquid (2g/kg bw, 0.1ml/10g bw), after 60min, normal group and hyperglycaemia pair
According to group with pure water gavage (equal-volume is in embodiment 4-6 digestion-promoting stomachic group), embodiment 4-6 digestion-promoting stomachic group pours into enforcement
Example 4-6 digestion-promoting stomachic lapping liquids.Hereafter blood glucose value is determined every 30min.The results are shown in Table 2.
2 digestion-promoting stomachic of table is to hyperglycaemia blood sugar influence
As known from Table 2, during gavage 60min, embodiment 4-6 digestion-promoting stomachic group significantly reduces the blood sugar level of mouse.
Above example is only several embodiments of the present invention, but the present invention is not limited to this.Based in the present invention
Embodiment, all other embodiment party that those of ordinary skill in the art are obtained on the premise of any creative work is not made
Formula, belongs to the scope protected by the present invention.
Claims (8)
1. a kind of digestion-promoting stomachic, including the raw material of following weight part ratio：Balloonflower root stem cell dry powder 10-20 parts, water 30-40 parts.
2. digestion-promoting stomachic according to claim 1, it is characterised in that the preparation method of the balloonflower root stem cell dry powder is：
Balloonflower root main root sterilization is taken, and is whittled into aseptic thin slice and with hypertonic solution process, inducing culture is transferred to there is cell to grow,
Then explant subculture to growth medium culture 10-20d is obtained into balloonflower root forming layer stem cell, Amplification Culture, ultrafiltration clone,
The macromolecular mass retained with 70-90% ethanol elutions, with second half without Ultrasonic Pulverization after half macromolecular mass Ultrasonic Pulverization
Macromolecular mass distinguishes the 1/5-1/3 of rotary evaporation to effluent volume, is pulverized and mixed after vacuum freeze drying.
3. digestion-promoting stomachic according to claim 2, it is characterised in that balloonflower root in the balloonflower root stem cell process for preparation of dry powder
Cefalexin pretreatment 3-5h of the method for main root sterilization for 0.3-0.8%, then aseptic water washing 20-30min, is put into
Sterilization 50-90s, aseptic water washing 4-8min in 70% ethanol solution.
4. digestion-promoting stomachic according to claim 2, it is characterised in that the balloonflower root stem cell process for preparation of dry powder middle and high infiltration
Glucose solution of the solution for 20-40%.
5. digestion-promoting stomachic according to claim 2, it is characterised in that ultrafiltration in the balloonflower root stem cell process for preparation of dry powder
The milipore filter molecular weight for using is 8000-12000.
6. digestion-promoting stomachic according to claim 2, it is characterised in that rotate in the balloonflower root stem cell process for preparation of dry powder
The temperature of evaporation is 65-75 DEG C.
7. digestion-promoting stomachic according to claim 2, it is characterised in that induce in the balloonflower root stem cell process for preparation of dry powder
Culture medium is 1/2MS culture medium+0.3-0.6mg/L NAA+1.2-1.8mg/L niacins.
8. the digestion-promoting stomachic according to any one of claim 1-7, it is characterised in that the balloonflower root stem cell dry powder preparation side
In method, growth medium is MS culture medium+0.35-0.65mg/L 6-BA+0.01-0.04mg/LNAA+90-110mg/L lemons
Acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710012742.XA CN106511430A (en) | 2017-01-06 | 2017-01-06 | Digestive and stomachics tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710012742.XA CN106511430A (en) | 2017-01-06 | 2017-01-06 | Digestive and stomachics tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106511430A true CN106511430A (en) | 2017-03-22 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710012742.XA Pending CN106511430A (en) | 2017-01-06 | 2017-01-06 | Digestive and stomachics tablet |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104719914A (en) * | 2015-04-09 | 2015-06-24 | 广州赛莱拉干细胞科技股份有限公司 | Combination capable of improving gastric-intestinal functions and preparation method of combination |
| CN105233101A (en) * | 2015-11-19 | 2016-01-13 | 刘书元 | Stomachic digestion tablet |
| CN105327216A (en) * | 2015-12-01 | 2016-02-17 | 青岛新中新新材料有限公司 | Stomach invigorating digestion tablet and preparation method thereof |
| CN105381337A (en) * | 2015-11-19 | 2016-03-09 | 刘书元 | Jianwei Xiaoshi tablet |
-
2017
- 2017-01-06 CN CN201710012742.XA patent/CN106511430A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104719914A (en) * | 2015-04-09 | 2015-06-24 | 广州赛莱拉干细胞科技股份有限公司 | Combination capable of improving gastric-intestinal functions and preparation method of combination |
| CN105233101A (en) * | 2015-11-19 | 2016-01-13 | 刘书元 | Stomachic digestion tablet |
| CN105381337A (en) * | 2015-11-19 | 2016-03-09 | 刘书元 | Jianwei Xiaoshi tablet |
| CN105327216A (en) * | 2015-12-01 | 2016-02-17 | 青岛新中新新材料有限公司 | Stomach invigorating digestion tablet and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘立萍等: "桔梗潜在功能的考察与分析", 《中药药理与临床》 * |
| 黄海茵等: "体外细胞培养应用于中药复方研究的进展", 《中国中西医结合杂志》 * |
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