CN106495681A - A kind of bioceramic - Google Patents
A kind of bioceramic Download PDFInfo
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- CN106495681A CN106495681A CN201610934692.6A CN201610934692A CN106495681A CN 106495681 A CN106495681 A CN 106495681A CN 201610934692 A CN201610934692 A CN 201610934692A CN 106495681 A CN106495681 A CN 106495681A
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- bioceramic
- zirconium oxide
- tricalcium phosphate
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- C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
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Abstract
The invention discloses a kind of bioceramic, is related to technical field of biological material, it is prepared from by each component of following mass fraction:25 parts of 40 60 parts of tricalcium phosphate, 20 40 parts of zirconium oxide, 5 15 parts of calcium silicates, 36 parts of nano-titanium oxide, 36 parts of medical stone powder, 49 parts of potassium metaphosphate and nanometer tungsten oxide.A kind of preparation method of tricalcium phosphate/zirconium oxide bioceramic, preparation process are as follows:(1) weigh;(2) ball milling;(3) cold moudling;(4) high-temperature calcination;(5) cool down.Preferably, biological activity is higher, while with good comprcssive strength and fracture toughness, being a kind of preferable bone repair substitution material for tricalcium phosphate/zirconium oxide bioceramic biocompatibility that the present invention is provided.
Description
Technical field
The invention belongs to technical field of biological material, more particularly to a kind of tricalcium phosphate/zirconium oxide bioceramic and biology pottery
The preparation method of porcelain.
Background technology
With the development of material science and technology, the particularity repaired to body tissue, substituted and regenerated because of which by biomaterial
Can, have become one of important research direction of current biomedical sector.Biological hard tissue substitute material is to use body earliest
Bone, animal bone, were developed into later using rustless steel and plastics, and as rustless steel has dissolved, corrosion and fatigue problem, plastics are deposited
In stability difference and the problem of low intensity.The bottleneck of biomaterial development is thus resulted in, the appearance of bioceramic is improved existing
The deficiency of substitution material, because of its many advantages, therefore, bioceramic is provided with vast potential for future development.
Calcium phosphate ceramic (CPC) is the important species in biological active ceramic material, and studying at present and applying most is
Hydroxyapatite (HA) and tricalcium phosphate (TCP).Calcium phosphate ceramic contains CaO and P2O5Two kinds of compositions, are to constitute human body hard tissue
Important inorganic substances, be implanted into human body after, its surface can be reached completely affine by the combination of key with tissue.
Wherein, in tricalcium phosphate (TCP), the biodegradable ceramic bata-tricalcium phosphate (abbreviation β-TCP) that is widely used at present,
Category trigonal system, calcium phosphorus atoms ratio is 1.5, is a kind of high-temperature-phase of calcium phosphate.The sharpest edges of β-TCP are exactly biocompatibility
Good, directly merge with bone after implanting to human body, without any local inflammatory response and whole body toxic and side effects.
Calcium-phosphorus ratio plays an important role on internal dissolubility and absorption trend is determined, so compare TCP with HA being easier to
Dissolve in vivo, its dissolubility is about high than HA 10-20 times.Conventional β-TCP implant and gradually can degrade, and degradation rate can be because
Its surface structure, crystallographic configurations containing porosity and are implanted into the different and different of animal, and its intensity often weakens with degraded.
With other ceramic phase ratios, β-TCP potteries are more closely similar to the property and structure of people's bone and natural teeth in vivo, hydroxyl
The dissolving of base apatite is harmless, and forms new bone by calcium and phosphate anion etc. is supplemented from body fluid, can be in skeleton
Joint interface produces the reactions such as decomposition, absorption and precipitation, realizes strong bonded.
The shortcoming of β-TCP potteries is that mechanical strength is low, is unable to undergo the impact of power.β-TCP are mixed with other materials, is made
Into two-phase or multiphase ceramic, it is to improve one of method of its mechanical strength.
Content of the invention
Present invention solves the technical problem that:For above-mentioned deficiency, the defect of prior art is overcome, the purpose of the present invention is to carry
For a kind of tricalcium phosphate/zirconium oxide bioceramic and preparation method thereof.
Technical scheme:A kind of tricalcium phosphate/zirconium oxide bioceramic, by each component of following mass fraction
It is prepared from:
Tricalcium phosphate 40-60 parts, zirconium oxide 20-40 parts, calcium silicates 5-15 parts, nano-titanium oxide 3-6 parts, medical stone powder 3-6 parts,
Potassium metaphosphate 4-9 parts and nanometer tungsten oxide 2-5 parts.
Preferably, the mass fraction of each component is:Tricalcium phosphate 45-58 parts, zirconium oxide 25-36 parts, calcium silicates 9-
12 parts, nano-titanium oxide 4-5 parts, medical stone powder 4-5 parts, potassium metaphosphate 6-8 parts and nanometer tungsten oxide 3-4 parts.
Preferably, the mass fraction of each component is:52 parts of tricalcium phosphate, 32 parts of zirconium oxide, calcium silicates 10 part, nanometer
3 parts of 4 parts of titanium oxide, 5 parts of medical stone powder, 7 parts of potassium metaphosphate and nanometer tungsten oxide.
A kind of preparation method of tricalcium phosphate/zirconium oxide bioceramic, preparation process are as follows:
(1)Weigh:Each component is accurately weighed;
(2)Ball milling:Each component is mixed, ball mill is put into and is ground mixing;
(3)Cold moudling:Mixed powder is carried out cold moudling;
(4)It is put into after powder body molding in mould, carries out high-temperature calcination, temperature is 1100 DEG C -1350 DEG C, pressure 300-700MPa,
Time 2-8h;
(5)After calcining, taking-up to be cooled obtains pain phosphorus acid DFP/zirconium oxide bioceramic.
Preferably, step(4)The temperature of middle calcining is 1200 DEG C.
Preferably, step(4)The pressure of middle calcining is 580MPa.
Beneficial effect:Tricalcium phosphate/zirconium oxide bioceramic that the present invention is provided, is a kind of composite bio-active pottery,
Tricalcium phosphate bioactive ceramicses have very good biocompatibility, and can slowly discharge calcium and phosphorus ionses, but its mechanics
Performance is less desirable;Zirconium oxide bioceramic is bio-inert ceramic, and preferably, mechanical property is preferable for biocompatibility, but simultaneously
Do not possess biological activity, therefore, two-by-two plant bioceramic material be combined together, prepare two-phase composite boilogical ceramic, not only after
The excellent biological activity of tricalcium phosphate is held, and has improve the mechanical property of bioceramic.
Therefore, preferably, biological activity is higher for tricalcium phosphate/zirconium oxide bioceramic biocompatibility that the present invention is provided,
There is good comprcssive strength and fracture toughness simultaneously, be a kind of preferable bone repair substitution material.
Specific embodiment
For a further understanding of the present invention, the preferred embodiment of the invention is described with reference to embodiment, but
It should be appreciated that these descriptions are simply for further illustrating the features and advantages of the present invention, rather than to the claims in the present invention
Limit.
Embodiment 1:
A kind of tricalcium phosphate/zirconium oxide bioceramic, including each component of following mass fraction:
40 parts of tricalcium phosphate, 20 parts of zirconium oxide, 5 parts of calcium silicates, 3 parts of nano-titanium oxide, 3 parts of medical stone powder, 4 parts of potassium metaphosphate and
2 parts of nanometer tungsten oxide.
Tricalcium phosphate/zirconium oxide bioceramic is prepared according to the preparation method that the present invention is provided, step is as follows:
(1)Weigh:Each component is accurately weighed;
(2)Ball milling:Each component is mixed, ball mill is put into and is ground mixing;
(3)Cold moudling:Mixed powder is suppressed using 60T press;
(4)It is put into after powder body molding in mould, carries out high-temperature calcination, temperature is 1300 DEG C, pressure 400MPa, time 4h;
(5)After calcining, taking-up to be cooled obtains pain phosphorus acid DFP/zirconium oxide bioceramic.
Block tricalcium phosphate/zirconium oxide the bioceramic for obtaining is detected, the performance of bioceramic is detected:Hardness
1020HV;Compressive strength 1790MPa;Bending strength 780MPa;Toughness 16MPa m1/2.
Embodiment 2:
A kind of tricalcium phosphate/zirconium oxide bioceramic, including each component of following mass fraction:
60 parts of tricalcium phosphate, 40 parts of zirconium oxide, 15 parts of calcium silicates, 6 parts of nano-titanium oxide, 6 parts of medical stone powder, 9 parts of potassium metaphosphate
With 5 parts of nanometer tungsten oxide.
Tricalcium phosphate/zirconium oxide bioceramic is prepared according to the preparation method that the present invention is provided, step is as follows:
(1)Weigh:Each component is accurately weighed;
(2)Ball milling:Each component is mixed, ball mill is put into and is ground mixing;
(3)Cold moudling:Mixed powder is suppressed using 60T press;
(4)It is put into after powder body molding in mould, carries out high-temperature calcination, temperature is 1300 DEG C, pressure 400MPa, time 7h;
(5)After calcining, taking-up to be cooled obtains pain phosphorus acid DFP/zirconium oxide bioceramic.
Block tricalcium phosphate/zirconium oxide the bioceramic for obtaining is detected, the performance of bioceramic is detected:Hardness
1050HV;Compressive strength 1820MPa;Bending strength 830MPa;Toughness 18MPa m1/2.
Embodiment 3:
A kind of tricalcium phosphate/zirconium oxide bioceramic, including each component of following mass fraction:
Tricresyl phosphate Ca45 part, 25 parts of zirconium oxide, 9 parts of calcium silicates, 4 parts of nano-titanium oxide, 4 parts of medical stone powder, 6 parts of potassium metaphosphate and
3 parts of nanometer tungsten oxide.
Tricalcium phosphate/zirconium oxide bioceramic is prepared according to the preparation method that the present invention is provided, step is as follows:
(1)Weigh:Each component is accurately weighed;
(2)Ball milling:Each component is mixed, ball mill is put into and is ground mixing;
(3)Cold moudling:Mixed powder is suppressed using 60T press;
(4)It is put into after powder body molding in mould, carries out high-temperature calcination, temperature is 1200 DEG C, pressure 580MPa, time 6h;
(5)After calcining, taking-up to be cooled obtains pain phosphorus acid DFP/zirconium oxide bioceramic.
Block tricalcium phosphate/zirconium oxide the bioceramic for obtaining is detected, the performance of bioceramic is detected:Hardness
1030HV;Compressive strength 1810MPa;Bending strength 790MPa;Toughness 16MPa m1/2.
Embodiment 4:
A kind of tricalcium phosphate/zirconium oxide bioceramic, including each component of following mass fraction:
58 parts of tricalcium phosphate, 36 parts of zirconium oxide, 12 parts of calcium silicates, 5 parts of nano-titanium oxide, 5 parts of medical stone powder, 8 parts of potassium metaphosphate
With 4 parts of nanometer tungsten oxide.
Tricalcium phosphate/zirconium oxide bioceramic is prepared according to the preparation method that the present invention is provided, step is as follows:
(1)Weigh:Each component is accurately weighed;
(2)Ball milling:Each component is mixed, ball mill is put into and is ground mixing;
(3)Cold moudling:Mixed powder is suppressed using 60T press;
(4)It is put into after powder body molding in mould, carries out high-temperature calcination, temperature is 1200 DEG C, pressure 580MPa, time 6h;
(5)After calcining, taking-up to be cooled obtains pain phosphorus acid DFP/zirconium oxide bioceramic.
Block tricalcium phosphate/zirconium oxide the bioceramic for obtaining is detected, the performance of bioceramic is detected:Hardness
1040HV;Compressive strength 1810MPa;Bending strength 800MPa;Toughness 17MPa m1/2.
Embodiment 5:
A kind of tricalcium phosphate/zirconium oxide bioceramic, including each component of following mass fraction:
52 parts of tricalcium phosphate, 32 parts of zirconium oxide, 10 parts of calcium silicates, 4 parts of nano-titanium oxide, 5 parts of medical stone powder, 7 parts of potassium metaphosphate
With 3 parts of nanometer tungsten oxide.
Tricalcium phosphate/zirconium oxide bioceramic is prepared according to the preparation method that the present invention is provided, step is as follows:
(1)Weigh:Each component is accurately weighed;
(2)Ball milling:Each component is mixed, ball mill is put into and is ground mixing;
(3)Cold moudling:Mixed powder is suppressed using 60T press;
(4)It is put into after powder body molding in mould, carries out high-temperature calcination, temperature is 1200 DEG C, pressure 580MPa, time 5h;
(5)After calcining, taking-up to be cooled obtains pain phosphorus acid DFP/zirconium oxide bioceramic.
Block tricalcium phosphate/zirconium oxide the bioceramic for obtaining is detected, the performance of bioceramic is detected:Hardness
1040HV;Compressive strength 1820MPa;Bending strength 800MPa;Toughness 17MPa m1/2.
The foregoing description of the disclosed embodiments, enables professional and technical personnel in the field to realize or using the present invention.
Multiple modifications of these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized without departing from the spirit or scope of the present invention in other embodiments.Therefore, the present invention
The embodiments shown herein is not intended to be limited to, and is to fit to and principles disclosed herein and features of novelty phase one
The most wide scope for causing.
Claims (1)
1. a kind of tricalcium phosphate/zirconium oxide bioceramic, it is characterised in that prepared by each component of following mass fraction and
Into:
58 parts of tricalcium phosphate, 36 parts of zirconium oxide, 12 parts of calcium silicates, 5 parts of nano-titanium oxide, 5 parts of medical stone powder, 8 parts of potassium metaphosphate
With 4 parts of nanometer tungsten oxide;
The preparation method of described tricalcium phosphate/zirconium oxide bioceramic, preparation process are as follows:
(1)Weigh:Each component is accurately weighed;
(2)Ball milling:Each component is mixed, ball mill is put into and is ground mixing;
(3)Cold moudling:Mixed powder is carried out cold moudling;
(4)It is put into after powder body molding in mould, carries out high-temperature calcination, temperature is 1200 DEG C, pressure 580MPa, time 6h;
(5)After calcining, taking-up to be cooled obtains pain phosphorus acid DFP/zirconium oxide bioceramic.
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CN201610934692.6A CN106495681A (en) | 2015-03-31 | 2015-03-31 | A kind of bioceramic |
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CN201610934695.XA Withdrawn CN106495683A (en) | 2015-03-31 | 2015-03-31 | Bone repair is substituted uses tricalcium phosphate zirconium oxide bioceramic |
CN201610936807.5A Withdrawn CN106365631A (en) | 2015-03-31 | 2015-03-31 | Alternative biological ceramic for bone repair |
CN201610934694.5A Withdrawn CN106518048A (en) | 2015-03-31 | 2015-03-31 | High biological activity substitute bioceramic for bone repair |
CN201610934693.0A Withdrawn CN106495682A (en) | 2015-03-31 | 2015-03-31 | Biological activity is higher, the preparation method of bone repair replacement bioceramic |
CN201610936808.XA Withdrawn CN106565230A (en) | 2015-03-31 | 2015-03-31 | Method for preparing biological ceramic having better biocompatibility and for bone repairing and replacement |
CN201610934692.6A Withdrawn CN106495681A (en) | 2015-03-31 | 2015-03-31 | A kind of bioceramic |
CN201610935856.7A Withdrawn CN106365630A (en) | 2015-03-31 | 2015-03-31 | Biological ceramic with good compressive strength and breaking tenacity |
CN201510146812.1A Active CN104803671B (en) | 2015-03-31 | 2015-03-31 | A kind of tricalcium phosphate/zirconium oxide bioceramic and preparation method thereof |
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CN201610936807.5A Withdrawn CN106365631A (en) | 2015-03-31 | 2015-03-31 | Alternative biological ceramic for bone repair |
CN201610934694.5A Withdrawn CN106518048A (en) | 2015-03-31 | 2015-03-31 | High biological activity substitute bioceramic for bone repair |
CN201610934693.0A Withdrawn CN106495682A (en) | 2015-03-31 | 2015-03-31 | Biological activity is higher, the preparation method of bone repair replacement bioceramic |
CN201610936808.XA Withdrawn CN106565230A (en) | 2015-03-31 | 2015-03-31 | Method for preparing biological ceramic having better biocompatibility and for bone repairing and replacement |
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CN115745599A (en) * | 2022-11-11 | 2023-03-07 | 深圳玉汝成口腔材料有限公司 | Zirconium oxide-based antibacterial denture material and preparation method thereof |
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CN105837245A (en) * | 2016-03-31 | 2016-08-10 | 青岛百瑞吉生物工程有限公司 | Preparation method for hydroxyapatite porous bioceramic |
CN107512923B (en) * | 2017-08-31 | 2021-04-13 | 安徽智博新材料科技有限公司 | Porous wear-resistant biological ceramic material and preparation method thereof |
CN108950634A (en) * | 2018-08-16 | 2018-12-07 | 张家港市六福新材料科技有限公司 | A kind of preparation method based on zirconium oxide Biocomposite material |
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SE513036C2 (en) * | 1998-10-02 | 2000-06-26 | Doxa Certex Ab | Methods to prepare improved biofunctional composite materials based on apatite by minimizing unwanted reactions in the preparation of the materials |
JP2004511320A (en) * | 2000-10-16 | 2004-04-15 | ユニバーシテイ・オブ・サウス・カロライナ | Biocompatible cement containing reactive calcium phosphate nanoparticles and methods of making and using said cement |
SE0300620D0 (en) * | 2003-03-05 | 2003-03-05 | Bone Support Ab | A new bone substitute composition |
CN1232472C (en) * | 2003-12-17 | 2005-12-21 | 天津大学 | Process for preparing self-growing calcium phosphate crystal whisker strengthened porous bioceramic materials |
CN1256153C (en) * | 2003-12-24 | 2006-05-17 | 中国人民解放军第二军医大学 | Nano zirconium oxide tough-ened high porosity calcium phosphate artificial bone rack and its preparing method |
CN100491288C (en) * | 2005-09-06 | 2009-05-27 | 四川大学 | Preparation method of nano porous biologic ceramics |
CN100455537C (en) * | 2005-10-27 | 2009-01-28 | 中国科学院上海硅酸盐研究所 | Process for preparing biological ceramic material of transparent bata-tricalcium phosphate and application thereof |
CN101695586B (en) * | 2009-10-30 | 2012-11-07 | 河北工业大学 | High-intensity porous bone repair material and method for preparing same |
CN101700415A (en) * | 2009-11-13 | 2010-05-05 | 中国科学院上海硅酸盐研究所 | Calcium silicate/hydroxylapatite composite biological ceramic material and preparation method and application thereof |
CN104446462A (en) * | 2014-11-10 | 2015-03-25 | 苏州维泰生物技术有限公司 | Zirconia biological ceramic and preparation method thereof |
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CN115745599A (en) * | 2022-11-11 | 2023-03-07 | 深圳玉汝成口腔材料有限公司 | Zirconium oxide-based antibacterial denture material and preparation method thereof |
CN115745599B (en) * | 2022-11-11 | 2023-10-31 | 深圳玉汝成口腔材料有限公司 | Zirconia-based antibacterial denture material and preparation method thereof |
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CN106565230A (en) | 2017-04-19 |
CN106518048A (en) | 2017-03-22 |
CN104803671B (en) | 2017-03-15 |
CN104803671A (en) | 2015-07-29 |
CN106365630A (en) | 2017-02-01 |
CN106495683A (en) | 2017-03-15 |
CN106495682A (en) | 2017-03-15 |
CN106365631A (en) | 2017-02-01 |
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