CN106492503A - Large-scale chromatographic column based on quartz - Google Patents
Large-scale chromatographic column based on quartz Download PDFInfo
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- CN106492503A CN106492503A CN201611023700.8A CN201611023700A CN106492503A CN 106492503 A CN106492503 A CN 106492503A CN 201611023700 A CN201611023700 A CN 201611023700A CN 106492503 A CN106492503 A CN 106492503A
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- Prior art keywords
- quartz
- chromatography
- pipe
- quartzy
- chromatographic column
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention discloses a kind of large-scale chromatographic column based on quartz, including chromatography pipe, the cavity that chromatography liquid passes through is provided with inside chromatography pipe, bottom is provided with screen plate, chromatography pipe and screen plate are made by quartz material, screen plate is formed by fixedly connecting by the quartz flange and multilamellar quartz drainage screen for being located at two ends, and per layer of quartzy drainage screen is formed with diamond-shaped manner braiding by quartz fibre；Chromatograph pipe is respectively arranged at two ends with upper support seat and lower support base, two support bases are fixedly connected by pull bar, are provided with connecting seat above upper support seat, are provided with piston in the middle part of connecting seat, the outer end of piston is connected with pipeline, is provided with the outlet of external delivery pipe in the middle part of lower support base.The present invention chromatography pipe the characteristics of be easy to seamless welding using quartz, reduces flange connection based on quartz material；Screen plate includes that multilamellar quartz drainage screen and quartz flange, overall structure performance preferably, are unlikely to deform damage, extension fixture whole service life.
Description
Technical field
The present invention relates to technical field of chemical, and in particular to a kind of large-scale chromatographic column based on quartz.
Background technology
Chromatography is the abbreviation of " chromatographic analyses ", with the difference of each component physical property, multicomponent mixture is separated
And method for measuring.Can be divided into by the mechanism of chromatography:Adsorption chromatography, Partition Chromatography, ion-exchange chromatography, Gel filtration
Analysis, affinity chromatograph etc..It is generally used for the analysis of organic compound, metal ion, aminoacid etc..Chromatography is using material in fixing phase
Different allocation proportion between mobile phase, reaches the technology for separating purpose.Chromatography is to biomacromolecule such as protein and nucleic acid
Separation analysis in the mixture of complicated Organic substance has high resolving power.
Now widely used chromatographic column, mainly includes that a glass column, cylinder bottom arrange core filter plate and be used for hindering
Filler in bumping post.First select appropriate separation medium to be loaded with conventional method during use, fill out then plus in appropriate amount of buffer solution balance columns
Sample to be separated when the liquid page to be buffered drops to filler surface, is uniformly added to filler surface with dropper, treats that sample is complete by material
After falling into filler surface, adding suitable eluent carries out eluting, with post bottom outlet Valve controlling eluent flow rate, collects and flows out
Liquid, separates purpose so as to reach.
Existing large-scale chromatographic column is in use in place of Shortcomings, one be made of mostly for glass, exist intolerant to
High temperature, the problem for easily bursting, seam need to be connected with flange, and glass can not seamless welding；Large-scale chromatography on market
Post is substantially external product, needs special handling glass material, for distinguishing in two-layer different liquids and extraction mixing liquid
A kind of liquid in face, relatively costly.Two be large-scale chromatography pipe bear air pressure, machine pressure, extract pressure too big, glass holds very much
Easily burst, chemical field liquid mostly is strong acid, deep-etching liquid, burst rear potential safety hazard high.Three is the following filter plate of chromatography pipe
For politef material, screen plate is very easy to deform under big pressure, and service life is very short.
Content of the invention
It is an object of the invention to overcoming the above-mentioned problems in the prior art, there is provided a kind of large-scale layer based on quartz
Analysis post, have the advantages that high temperature resistant, be difficult to burst, screen plate is unlikely to deform, long service life.
For realizing above-mentioned technical purpose, above-mentioned technique effect is reached, the present invention is to be achieved through the following technical solutions：
A kind of large-scale chromatographic column based on quartz, including chromatography pipe, is provided with chromatography liquid by using inside the chromatography pipe
Cavity, bottom is provided with screen plate, and the chromatography pipe and screen plate are made by quartz material, and the screen plate is by being located at two ends
Quartz flange and positioned between two quartz flanges multilamellar quartz drainage screen be formed by fixedly connecting, per layer of quartzy drainage screen
Formed with diamond-shaped manner braiding by quartz fibre；The chromatography pipe is respectively arranged at two ends with upper support seat and lower support base, described on
Support base is fixedly connected by pull bar with lower support base, is provided with connecting seat above the upper support seat, in the connecting seat
Portion is provided with the hollow piston for limiting chromatography gel location, and the outer end of the piston is connected with the pipe communicated with its hollow pipeline
Road, is provided with downward projection of outlet in the middle part of the lower support base, the outlet is circumscribed with delivery pipe.
Further, two quartz flanges are symmetrically welded on the inwall of chromatography pipe.
Further, a diameter of 0.02-0.12mm of the quartz fibre.
Further, through hole is offered, the edge of the through hole has been downwardly extending in the middle part of the upper support seat
The card pipe coordinated with chromatography bore.
Further, the connecting seat is by fixture and upper support seat detachable connection.
Further, the pull bar is made up of stainless steel material.
Further, the inner end of the piston circumferentially offers the fluting of installing sealing rubber ring.
The invention has the beneficial effects as follows：
1st, chromatography pipe is based on quartz material, the characteristics of be easy to seamless welding using quartz, reduces flange connection, and quartz has
Fusing point is more than 1200 degree, the advantage that corrosion-resistant, resistance to strong acid, high temperature resistant, hardness are 10 times or so of glass, applied range.
2nd, screen plate includes that multilamellar quartz drainage screen, good filtration effect, multilamellar quartz drainage screen pass through two ends quartz flange
It is clamped, quartz flange is welded on chromatography inside pipe wall and levelling position, is easy to eliminate quartzy drainage screen local ripple, is ensured
Filter effect；Screen plate overall structure performance preferably, is unlikely to deform damage, extension fixture whole service life.
Certainly, the arbitrary product for implementing the present invention is it is not absolutely required to while reaching all the above advantage.
Description of the drawings
In order to be illustrated more clearly that the technical scheme of the embodiment of the present invention, use required for describing to embodiment below
Accompanying drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the present invention, for ability
For the those of ordinary skill of domain, on the premise of not paying creative work, can be other attached to be obtained according to these accompanying drawings
Figure.
Fig. 1 is the structural representation of the present invention；
Fig. 2 be the present invention be applied in combination view；
Fig. 3 is the structural representation of screen plate in the present invention；
Fig. 4 is the structural representation of quartzy drainage screen in the present invention；
In accompanying drawing, the list of parts representated by each label is as follows：
1- chromatography pipes, 2- screen plates, 201- quartz flanges, 202- quartz drainage screens, 3- upper support seats, support base under 4-,
5- pull bars, 6- connecting seats, 7- pistons, 8- pipelines, 9- fixtures, 10- outlets.
Specific embodiment
Accompanying drawing in below in conjunction with the embodiment of the present invention, to the embodiment of the present invention in technical scheme carry out clear, complete
Site preparation is described, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiment.It is based on
Embodiment in the present invention, it is all other that those of ordinary skill in the art are obtained under the premise of creative work is not made
Embodiment, belongs to the scope of protection of the invention.
Refer to shown in Fig. 1-4, the present invention is a kind of large-scale chromatographic column based on quartz, including chromatographing pipe 1, chromatograph pipe 1
Inside is provided with the cavity that chromatography liquid passes through, and bottom is provided with screen plate 2, and chromatography pipe 1 and screen plate 2 are by quartz material system
Into multilamellar quartz drainage screen 202 of the screen plate 2 by the quartz flange 201 for being located at two ends and positioned between two quartz flanges 201 is solid
Surely it is formed by connecting, per layer of quartzy drainage screen 202 is formed with diamond-shaped manner braiding by quartz fibre；Chromatograph being respectively arranged at two ends with for pipe 1
Upper support seat 3 and lower support base 4, upper support seat 3 are fixedly connected by pull bar 5 with lower support base 4, and the top of upper support seat 3 sets
Have a connecting seat 6, the middle part of connecting seat 6 is provided with the hollow piston 7 for limiting chromatography gel location, the outer end of piston 7 be connected with
The pipeline 8 that its hollow pipeline is communicated, is provided with downward projection of outlet 10 in the middle part of lower support base 3, outlet 10 is circumscribed with conveying
Pipe.
Wherein, two quartz flanges 201 are symmetrically welded on the inwall of chromatography pipe.
Wherein, a diameter of 0.02-0.12mm of quartz fibre.
Wherein, the middle part of upper support seat 3 offers through hole, and the edge of through hole has been downwardly extending and has chromatographed in pipe 1
The card pipe that footpath coordinates.
Wherein, connecting seat 6 is by fixture 9 and 1 detachable connection of upper support seat.
Wherein, pull bar 5 is made up of stainless steel material.
Wherein, the inner end of piston 7 circumferentially offers the fluting of installing sealing rubber ring.
One of the present embodiment has particular application as：Chromatography pipe 1 is based on quartz material, the spy for being easy to seamless welding using quartz
Point, reduces flange connection, and quartz has fusing point more than 1200 degree, corrosion-resistant, resistance to strong acid, high temperature resistant, hardness are 10 times of glass
The advantage of left and right, applied range；Screen plate 2 includes multilamellar quartz drainage screen 202, good filtration effect, multilamellar quartz drainage screen
202 are clamped by two ends quartz flange 201, and quartz flange 201 is welded on chromatography 1 inwall of pipe and levelling position, is easy to
202 local ripple of quartzy drainage screen is eliminated, ensures that filter effect, 2 overall structure performance of screen plate preferably, are unlikely to deform damage,
Extension fixture whole service life.
Present invention disclosed above preferred embodiment is only intended to help and illustrates the present invention.Preferred embodiment is not detailed
All of details is described, it is only described specific embodiment also not limit the invention.Obviously, according to the content of this specification,
Can make many modifications and variations.This specification is chosen and specifically describes these embodiments, is to preferably explain the present invention
Principle and practical application so that skilled artisan can be best understood by and utilize the present invention.The present invention is only
Limited by claims and its four corner and equivalent.
Claims (7)
1. a kind of based on quartzy large-scale chromatographic column, including chromatography pipe, inside the chromatography pipe, it is provided with what chromatography liquid passed through
Cavity, bottom are provided with screen plate, it is characterised in that：The chromatography pipe and screen plate are made by quartz material, the screen plate
Multilamellar quartz drainage screen by the quartz flange for being located at two ends and positioned between two quartz flanges is formed by fixedly connecting, described in per layer
Quartzy drainage screen is formed with diamond-shaped manner braiding by quartz fibre；The chromatography pipe is respectively arranged at two ends with upper support seat and lower support
Seat, the upper support seat are fixedly connected by pull bar with lower support base, are provided with connecting seat, the company above the upper support seat
The hollow piston for limiting chromatography gel location is provided with the middle part of joint chair, and the outer end of the piston is connected with and its hollow pipeline phase
Logical pipeline, is provided with downward projection of outlet in the middle part of the lower support base, the outlet is circumscribed with delivery pipe.
2. according to claim 1 based on quartzy large-scale chromatographic column, it is characterised in that：Two quartz flanges are symmetrical
It is welded on the inwall of chromatography pipe.
3. according to claim 1 based on quartzy large-scale chromatographic column, it is characterised in that：The quartz fibre a diameter of
0.02-0.12mm.
4. according to claim 1 based on quartzy large-scale chromatographic column, it is characterised in that：Open in the middle part of the upper support seat
Through hole is provided with, the edge of the through hole is downwardly extending the card pipe coordinated with chromatography bore.
5. according to claim 1 based on quartzy large-scale chromatographic column, it is characterised in that：The connecting seat passes through fixture
With upper support seat detachable connection.
6. according to claim 1 based on quartzy large-scale chromatographic column, it is characterised in that：The pull bar is by stainless steel material
Make.
7. according to claim 1 based on quartzy large-scale chromatographic column, it is characterised in that：The inner end of the piston is along week
To the fluting for offering installing sealing rubber ring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611023700.8A CN106492503A (en) | 2016-11-14 | 2016-11-14 | Large-scale chromatographic column based on quartz |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611023700.8A CN106492503A (en) | 2016-11-14 | 2016-11-14 | Large-scale chromatographic column based on quartz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106492503A true CN106492503A (en) | 2017-03-15 |
Family
ID=58327243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611023700.8A Pending CN106492503A (en) | 2016-11-14 | 2016-11-14 | Large-scale chromatographic column based on quartz |
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| Country | Link |
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| CN (1) | CN106492503A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005105256A1 (en) * | 2004-03-30 | 2005-11-10 | Dr. Tittgen Biotechnologie | Filter with support cage |
| CN101241115A (en) * | 2007-02-08 | 2008-08-13 | 常晓宇 | Highly effective column chromatography and uses thereof |
| CN201799146U (en) * | 2010-08-23 | 2011-04-20 | 宁波杰顺生物科技有限公司 | Bottom filter device of chromatographic column |
| CN203408494U (en) * | 2013-08-02 | 2014-01-29 | 荣捷生物工程（苏州）有限公司 | Manual chromatographic column device |
-
2016
- 2016-11-14 CN CN201611023700.8A patent/CN106492503A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005105256A1 (en) * | 2004-03-30 | 2005-11-10 | Dr. Tittgen Biotechnologie | Filter with support cage |
| CN101241115A (en) * | 2007-02-08 | 2008-08-13 | 常晓宇 | Highly effective column chromatography and uses thereof |
| CN201799146U (en) * | 2010-08-23 | 2011-04-20 | 宁波杰顺生物科技有限公司 | Bottom filter device of chromatographic column |
| CN203408494U (en) * | 2013-08-02 | 2014-01-29 | 荣捷生物工程（苏州）有限公司 | Manual chromatographic column device |
Non-Patent Citations (2)
| Title |
|---|
| 张仁斌等: "《高效液相色谱——在医药研究中的应用》", 30 June 1983, 上海科学技术出版社 * |
| 金学平: "《化学制药工艺》", 30 January 2006, 化学工业出版社 * |
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Application publication date: 20170315 |
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