CN106483159A - A kind of biological medicine scintilla NMR analysis devices and its analysis method - Google Patents
A kind of biological medicine scintilla NMR analysis devices and its analysis method Download PDFInfo
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- CN106483159A CN106483159A CN201611038166.8A CN201611038166A CN106483159A CN 106483159 A CN106483159 A CN 106483159A CN 201611038166 A CN201611038166 A CN 201611038166A CN 106483159 A CN106483159 A CN 106483159A
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
- G01N24/087—Structure determination of a chemical compound, e.g. of a biomolecule such as a protein
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Abstract
The invention discloses a kind of biological medicine scintilla NMR analysis devices, including pedestal and analytical equipment body, described analytical equipment body is located at the top of pedestal, the top left side of described pedestal is installed with support, on described support, cylinder body is installed, described cylinder body outfan is connected with piston rod, described analytical equipment body interior offers sense channel, described sense channel is equipped with magnet up and down, sense channel is run through in described piston rod one end, and the end of described piston rod is connected with clamping device, described pedestal top right side is provided with mounting seat, described mounting seat top is provided with display device body.View data method for building up using nuclear magnetic resonance, NMR, image sequence is carried out registration, to eliminate the offset deviation that in image sequence, target area exists gathered data, data and curves are set up according to the signal intensity collecting and time relationship, and draw nuclear magnetic resonance spectroscopy conclusion according to data and curves, can be used with popularity.
Description
Technical field
The present invention relates to a kind of analytical equipment is and in particular to a kind of biological medicine scintilla NMR analysis devices.With
When, the invention still further relates to a kind of analysis method of biological medicine scintilla NMR analysis devices.
Background technology
Nuclear magnetic resonance, NMR is the atomic nucleus that magnetic moment is not zero, and under external magnetic field, spin energy level occurs Zeeman splitting, resonance
Absorb the physical process of the radio-frequency radiation of certain certain frequency.Nuclear magnetic resonance spectroscopy is a branch of spectroscopy, its resonance frequency
In radio-frequency range, corresponding transition is transition in core Zeeman level for the nuclear spin to rate.Nuclear magnetic resonance technique has in medical science
It is widely applied, NMR (Nuclear Magnetic Resonance)-imaging (MRI) checks a kind of common image check mode that has become as, NMR (Nuclear Magnetic Resonance)-imaging is made
For a kind of new Imaging Techniques, health will not be had an impact.
Pharmaceutical industries and Biomedical engineering industry are the Two Mainstays of modern medicine industry.Bio-pharmaceutical Industry is by biology
Technical industry is collectively constituted with medicinal industry.Various countries, each definition of tissue opposite thing technical industry and the scope of delineation are not united very much
One, or even the viewpoint of different people is also usually far from each other.Biomedical engineering is integrated application life sciences and engineering science
Principle and method, recognize human body from ergonomic point at many levels in molecule, cell, tissue, organ or even whole body system
Structure, function and other biosiss, study for diseases prevention, cure the disease, bodily fuctions' auxiliary and the artificial material of health care, system
The general name of product, device and systems technology.At present, biological medicine scintilla NMR analysis devices biological medicine is had important
Effect, biological medicine scintilla NMR analysis devices complex operation of the prior art, target area exist displacement
Deviation is it is difficult to meet people's demand.
Content of the invention
It is an object of the invention to provide a kind of biological medicine scintilla NMR analysis devices and its analysis method,
To solve the problems, such as to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme：A kind of biological medicine scintilla nuclear magnetic resonance spectroscopy
Device, including pedestal and analytical equipment body, described analytical equipment body is located at the top of pedestal, the top left side of described pedestal
It is installed with support, described support is provided with cylinder body, described cylinder body outfan is connected with piston rod, described point
Analysis apparatus body interior offers sense channel, and described sense channel is equipped with magnet up and down, and inspection is run through in described piston rod one end
Survey passage, and the end of described piston rod is connected with clamping device, described pedestal top right side is provided with mounting seat, described mounting seat
Top is provided with display device body.
Preferably, described clamping device is divided into two to be connected with spring between fixture, and fixture.
Preferably, described clamping device is also arranged with draw-in groove, and described draw-in groove is circular arc.
Preferably, described display device body includes mouse, keyboard and light-emitting diode display, on the right side of described display device body
It is connected with printing equipment body.
Present invention also offers a kind of analysis method of biological medicine scintilla NMR analysis devices, specifically include with
Lower step：
S1, raw material prepare, and take 5 grams -10 grams of testing sample, and testing sample is encapsulated in glass tubing, standby；
S2, the clamping of testing sample, by starting cylinder body, make piston rod extend to the right side of analytical equipment body,
And by S1 equipped with testing sample glass tubing clamping between the draw-in groove on clamping device；
S3, manufacture resonant field, by starting analytical equipment body, make to be formed between lower magnet on sense channel uniformly quiet
Magnetic field；
S5, the glass tubing entrance sense channel being made by startup cylinder body on piston rod drive clamping device, make to be measured
The uniform magnetostatic field that sample produces in S3 carries out nuclear magnetic resonance, NMR；
S6, using nuclear magnetic resonance, NMR view data method for building up, extract target area nuclear magnetic resonance image data；
S7, the image sequence in S6 is carried out registration, to eliminate the offset deviation that in image sequence, target area exists simultaneously
Gathered data；
S8, quantitative analyses, calculate each area pixel average, set up number according to the signal intensity collecting and time relationship
According to curve；
S9, draw nuclear magnetic resonance spectroscopy conclusion according to the data and curves in S8, and recorded；
S10, the data by nuclear magnetic resonance image, being collected by printer and nuclear magnetic resonance, NMR conclusion are printed and bind into book form.
The present invention provide a kind of biological medicine scintilla NMR analysis devices and its analysis method, with existing skill
Art is compared, and by starting cylinder body, so that piston rod is extended to the right side of analytical equipment body, and will be equipped with the glass of testing sample
Glass pipe clamping, between the draw-in groove on clamping device, makes testing sample carry out nuclear magnetic resonance, NMR in uniform magnetostatic field, using nuclear-magnetism
The view data method for building up of resonance, extracts the nuclear magnetic resonance image data of target area, image sequence is carried out registration, to disappear
The offset deviation existing except target area in image sequence gathered data, according to the signal intensity collecting and time relationship
Set up data and curves, and draw nuclear magnetic resonance spectroscopy conclusion according to data and curves, can be used with popularity.
Brief description
Fig. 1 is the structural representation of the present invention；
Fig. 2 is A portion of the present invention mplifying structure schematic diagram.
In figure：1 pedestal, 2 analytical equipment bodies, 3 supports, 4 cylinder bodies, 5 piston rods, 6 sense channels, 7 clamping devices,
8 springs, 9 mounting seats, 10 display device bodies, 11 printing equipment bodies, 12 magnets, 13 draw-in grooves.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation description is it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of not making creative work
Embodiment, broadly falls into the scope of protection of the invention.
The invention provides a kind of biological medicine scintilla NMR analysis devices, including pedestal 1 and analytical equipment basis
Body 2, described analytical equipment body 2 is located at the top of pedestal 1, and the top left side of described pedestal 1 is installed with support 3, described
Cylinder body 4 is provided with support 3, described cylinder body 4 outfan is connected with piston rod 5, inside described analytical equipment body 2
Offer sense channel 6, described sense channel is equipped with magnet 12 about 6, sense channel 6 is run through in described piston rod 5 one end, and
The end of described piston rod 5 is connected with clamping device 7, and described pedestal 1 top right side is provided with mounting seat 9, described mounting seat 9 top
It is provided with display device body 10, described clamping device 7 is divided into two to be connected with spring 8, described clamping between fixture, and fixture
Also it is arranged with draw-in groove 13 on device 7, and described draw-in groove 13 is circular arc, described display device body 10 includes mouse, keyboard
And light-emitting diode display, it is connected with printing equipment body 11 on the right side of described display device body 10.
Present invention also offers a kind of analysis method of biological medicine scintilla NMR analysis devices, specifically include with
Lower step：
S1, raw material prepare, and take 5 grams -10 grams of testing sample, and testing sample is encapsulated in glass tubing, standby；
S2, the clamping of testing sample, by starting cylinder body, make piston rod extend to the right side of analytical equipment body,
And by S1 equipped with testing sample glass tubing clamping between the draw-in groove on clamping device；
S3, manufacture resonant field, by starting analytical equipment body, make to be formed between lower magnet on sense channel uniformly quiet
Magnetic field；
S5, the glass tubing entrance sense channel being made by startup cylinder body on piston rod drive clamping device, make to be measured
The uniform magnetostatic field that sample produces in S3 carries out nuclear magnetic resonance, NMR；
S6, using nuclear magnetic resonance, NMR view data method for building up, extract target area nuclear magnetic resonance image data；
S7, the image sequence in S6 is carried out registration, to eliminate the offset deviation that in image sequence, target area exists simultaneously
Gathered data；
S8, quantitative analyses, calculate each area pixel average, set up number according to the signal intensity collecting and time relationship
According to curve；
S9, draw nuclear magnetic resonance spectroscopy conclusion according to the data and curves in S8, and recorded；
S10, the data by nuclear magnetic resonance image, being collected by printer and nuclear magnetic resonance, NMR conclusion are printed and bind into book form.
In sum, compared with prior art, it is an advantage of the invention that：By starting cylinder body 4, piston rod 5 is made to stretch
The long right side to analytical equipment body 2, and will be equipped with the glass tubing clamping of the testing sample draw-in groove 13 on clamping device 7 it
Between, make testing sample carry out nuclear magnetic resonance, NMR in uniform magnetostatic field, using the view data method for building up of nuclear magnetic resonance, NMR, extract mesh
The nuclear magnetic resonance image data in mark region, image sequence is carried out registration, to eliminate the position that in image sequence, target area exists
Move deviation gathered data, data and curves are set up according to the signal intensity collecting and time relationship, and according to data and curves
Draw nuclear magnetic resonance spectroscopy conclusion, can be used with popularity.
Finally it should be noted that：The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention,
Although being described in detail to the present invention with reference to the foregoing embodiments, for a person skilled in the art, it still may be used
To modify to the technical scheme described in foregoing embodiments, or equivalent is carried out to wherein some technical characteristics,
All any modification, equivalent substitution and improvement within the spirit and principles in the present invention, made etc., should be included in the present invention's
Within protection domain.
Claims (5)
1. a kind of biological medicine scintilla NMR analysis devices, including pedestal (1) and analytical equipment body (2), its feature
It is：Described analytical equipment body (2) is located at the top of pedestal (1), and the top left side of described pedestal (1) is installed with support
(3), described support (3) is provided with cylinder body (4), described cylinder body (4) outfan is connected with piston rod (5), described
Sense channel (6) is offered, described sense channel (6) is equipped with magnet (12), described work up and down inside analytical equipment body (2)
Sense channel (6) is run through in stopper rod (5) one end, and the end of described piston rod (5) is connected with clamping device (7), described pedestal (1)
Top right side is provided with mounting seat (9), and described mounting seat (9) top is provided with display device body (10).
2. a kind of biological medicine scintilla NMR analysis devices according to claim 1 it is characterised in that：Described folder
Tight device (7) is divided into two to be connected with spring (8) between fixture, and fixture.
3. a kind of biological medicine scintilla NMR analysis devices according to claim 1 it is characterised in that：Described folder
Also it is arranged with draw-in groove (13) on tight device (7), and described draw-in groove (13) is circular arc.
4. a kind of biological medicine scintilla NMR analysis devices according to claim 1 it is characterised in that：Described aobvious
Showing device body (10) includes mouse, keyboard and light-emitting diode display, is connected with printing equipment on the right side of described display device body (10)
Body (11).
5. a kind of analysis method of biological medicine scintilla NMR analysis devices according to claim 1, its feature
It is：Specifically include following steps：
S1, raw material prepare, and take 5 grams -10 grams of testing sample, and testing sample is encapsulated in glass tubing, standby；
S2, the clamping of testing sample, by starting cylinder body, make piston rod extend to the right side of analytical equipment body, and will
In S1 equipped with testing sample glass tubing clamping between the draw-in groove on clamping device；
S3, manufacture resonant field, by starting analytical equipment body, make to be formed between lower magnet on sense channel uniformly magnetostatic
?；
S5, the glass tubing entrance sense channel being made by startup cylinder body on piston rod drive clamping device, make testing sample
The uniform magnetostatic field producing in S3 carries out nuclear magnetic resonance, NMR；
S6, using nuclear magnetic resonance, NMR view data method for building up, extract target area nuclear magnetic resonance image data；
S7, the image sequence in S6 is carried out registration, to eliminate the offset deviation that in image sequence, target area exists and to gather
Data；
S8, quantitative analyses, calculate each area pixel average, set up data according to the signal intensity collecting and time relationship bent
Line；
S9, draw nuclear magnetic resonance spectroscopy conclusion according to the data and curves in S8, and recorded；
S10, the data by nuclear magnetic resonance image, being collected by printer and nuclear magnetic resonance, NMR conclusion are printed and bind into book form.
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| CN201611038166.8A CN106483159B (en) | 2016-11-23 | 2016-11-23 | A kind of biological medicine scintilla NMR analysis devices and its analysis method |
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| CN201611038166.8A CN106483159B (en) | 2016-11-23 | 2016-11-23 | A kind of biological medicine scintilla NMR analysis devices and its analysis method |
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| CN106483159A true CN106483159A (en) | 2017-03-08 |
| CN106483159B CN106483159B (en) | 2018-11-13 |
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| CN103927733A (en) * | 2013-01-11 | 2014-07-16 | 上海市第六人民医院 | Method for establishing image data through nuclear magnetic resonance |
| KR20140093651A (en) * | 2014-07-01 | 2014-07-28 | 김동식 | A jig Oil pressure |
| CN104215539A (en) * | 2014-07-31 | 2014-12-17 | 高德（无锡）电子有限公司 | Thermal-stress testing automatic device used for PCB industry |
| CN105784749A (en) * | 2016-04-08 | 2016-07-20 | 董印 | Magnetic resonance matter wave spectrogram inspection device |
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2016
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Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005026763A1 (en) * | 2003-09-09 | 2005-03-24 | Varian, Inc. | Radially-compact nmr flow cell assemblies |
| JP2007003444A (en) * | 2005-06-27 | 2007-01-11 | Jeol Ltd | Cavity resonator for esr |
| CN102579047A (en) * | 2012-04-10 | 2012-07-18 | 江苏美时医疗技术有限公司 | Special magnetic resonance imaging device for baby |
| CN103927733A (en) * | 2013-01-11 | 2014-07-16 | 上海市第六人民医院 | Method for establishing image data through nuclear magnetic resonance |
| CN103207199A (en) * | 2013-03-05 | 2013-07-17 | 杨晓冬 | Biomedical nuclear magnetic resonance device |
| KR20140093651A (en) * | 2014-07-01 | 2014-07-28 | 김동식 | A jig Oil pressure |
| CN104215539A (en) * | 2014-07-31 | 2014-12-17 | 高德（无锡）电子有限公司 | Thermal-stress testing automatic device used for PCB industry |
| CN105784749A (en) * | 2016-04-08 | 2016-07-20 | 董印 | Magnetic resonance matter wave spectrogram inspection device |
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| CN106483159B (en) | 2018-11-13 |
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Effective date of registration: 20200313 Address after: 510170 No.63 xizeng Road, Liwan District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Jiatu Technology Co., Ltd Address before: 810000 Qinghai province north of the city of Xining city district biological park by three road No. 7 Building No. 1 room 11118 Patentee before: QINGHAI QICAIHUA BIOTECHNOLOGY Co.,Ltd. |