CN103207199A - Biomedical nuclear magnetic resonance device - Google Patents
Biomedical nuclear magnetic resonance device Download PDFInfo
- Publication number
- CN103207199A CN103207199A CN2013100688144A CN201310068814A CN103207199A CN 103207199 A CN103207199 A CN 103207199A CN 2013100688144 A CN2013100688144 A CN 2013100688144A CN 201310068814 A CN201310068814 A CN 201310068814A CN 103207199 A CN103207199 A CN 103207199A
- Authority
- CN
- China
- Prior art keywords
- sample
- radio
- frequency
- coil
- magnet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
Abstract
The invention discloses a biomedical nuclear magnetic resonance device which comprises a frequency meter, a radiofrequency oscillator, a radiofrequency coil, a modulation receiver, a sample tube, a first magnet and a second magnet. The radiofrequency coil generates an alternating electromagnetic field according to pulse current from the radiofrequency oscillator, inductively generates sample feedback signals which represent the energy level of nuclear spin of a sample and comprises an even number of rectangular secondary coils, a long side of each rectangular secondary coil extends to form a first transmission line positioned in the axis of the radiofrequency coil, a short side, which is adjacent to the corresponding long side, of each rectangular secondary coil is bent and then extends to form a second transmission line, and the rectangular secondary coils are connected with one another in parallel and are equidistantly arranged to form the radiofrequency coil; the modulation receiver is connected to the radiofrequency oscillator; the sample tube is positioned on the axial line of the radiofrequency coil, is positioned under the radiofrequency coil and is mounted on a rotor fixing part; and the first magnet and the second magnet are respectively positioned on two sides of the sample tube. The biomedical nuclear magnetic resonance device has the advantages that the biomedical nuclear resonance device is high in quality factor, high-power excitation and excellent radiofrequency magnetic field distribution are realized, the measuring accuracy and the measuring sensitivity are greatly improved, the stability of a sample is improved when the sample rotates, and the jamming rate during sample loading is reduced.
Description
Technical field
The present invention relates to nuclear magnetic resonance spectroscopy device field, be specifically related to a kind of nuclear magnetic resonance device for biological medicine.
Background technology
In view of the widespread use of nuclear magnetic resonance technique in fundamental researchs such as chemistry, biology and clinical medicine, drug development, various high resolution NMR analytical technologies become the important tool in the Biochemical Research.Go for high-quality nmr spectrum, parameters such as the alternating temperature performance of nuclear magnetic resonance rotor adapter, rotational stabilization seem extremely important.Especially go for high-resolution nmr spectrum, need to use the bigger rotor adapter (200 to 200 ℃) of extent of alternating temperature and make sample rotation (greater than 20 rpm), need to guarantee sample tube stability when rotated this moment.Present common rotor adapter, correlation parameters such as the magnetic susceptibility of its material and mass distribution all do not satisfy the demand of using in than large-temperature range, and under high rotating speed, the less stable of rotor adapter, it is very complicated that feasible process of carrying out the high resolution NMR experiment becomes.
On the other hand, go for high-quality nmr spectrum, the load power of NMR RF coil, the parameters such as homogeneity of radio-frequency (RF) magnetic field seem extremely important.Especially go for high-resolution nmr spectrum, often need to use the higher radio-frequency coil (greater than 20kHz) of load power, just have higher requirement for geometric configuration and the space structure of radio-frequency coil this moment.Present common radio-frequency coil, as the solenoid type radio-frequency coil, and Hai Muhuozi type radio-frequency coil, the maximum intensity of the radio-frequency field that it can apply is 10 ~ 15kHz, do not satisfy the demand apply more high-power radio-frequency field, make that carrying out the high resolution NMR experiment becomes and be difficult to carry out.
Summary of the invention
The invention provides a kind of nuclear magnetic resonance device for biological medicine, this nuclear magnetic resonance spectroscopy device has higher quality factor, has realized that high-power exciting and good radio-frequency (RF) magnetic field distribute, and have improved precision and the sensitivity of measuring greatly; And the stability when strengthening the sample rotation, thereby improved the accuracy of rotation and irrotational nuclear magnetic resonance data, the rate that gets stuck when this design has simultaneously also reduced last sample.
For achieving the above object, the technical solution used in the present invention is: a kind of nuclear magnetic resonance device for biological medicine comprises:
Frequency meter is for generation of radio-frequency (RF) pulse signal;
Radio-frequency oscillator produces corresponding pulse current according to the radio-frequency (RF) pulse signal from described frequency meter, and receives the sample feedback signal from radio-frequency coil;
Radio-frequency coil, according to the pulse current product alternating electromagnetic field from described radio-frequency oscillator, and induction generates the sample feedback signal that characterizes sample nuclear spin energy level, described radio-frequency coil comprises even number rectangle subcoil, first transmission line that back formation one is positioned at the axle center is extended on the long limit of one side of this rectangle subcoil, extend to form second transmission line after the adjacent minor face bending in long limit therewith, several rectangle subcoils are in parallel and uniformly-spaced arrange and form described radio-frequency coil;
Modulator receiver is connected to described radio-frequency oscillator, is used for extracting the sample feedback signal from radio-frequency oscillator;
The sample hose that is used for the carrying detected sample is positioned on the described radio-frequency coil axial line and is positioned under it, and this sample hose is installed on the rotor fixture;
First magnet and second magnet lay respectively at described sample hose both sides, and being used for provides static magnetic field to the sample in this sample hose.
Further improvement project in the technique scheme is as follows:
1. in the such scheme, described several second transmission line other end bendings connect by a closed loop coil.
2. in the such scheme, the magnetic field intensity of described first magnet and second magnet is 1 ~ 1.2 tesla.
3. in the such scheme, described rectangle subcoil number is 6, and the adjacent rectangle subcoil is spaced apart 60 degree
4. in the such scheme, described scapus, tighten solid, fastener and cap body material are teflon down.
Because technique scheme is used, the present invention compared with prior art has following advantage and effect:
1. nuclear magnetic resonance device of the present invention, it is applicable to transmitting and receiving of pulse signal, can be used for the research of high resolution NMR experiment; This apparatus structure is tight, has higher quality factor, and the radio-frequency power that can carry is 30kHz, and the uniformity coefficient of radio-frequency (RF) magnetic field is 4.6%.Realized that high-power exciting and good radio-frequency (RF) magnetic field distribute, and have improved precision and the sensitivity of measuring greatly.
2. adopted six groups of leads in the nuclear magnetic resonance device of the present invention, compared with the Helmholtz coils that is made of two groups of leads with the solenoid type coil that traditional one group of lead constitutes, structure is meticulousr, can realize more complicated radio-frequency field.
3. coil device of the present invention has been realized high power, has six subcoils in a coil, and total radio-frequency power is distributed to six subcoils.Under the constant situation of each subcoil peak power, improved general power, therefore improved the resolution of imaging.
4. coil device of the present invention has improved the uniformity coefficient of radio-frequency (RF) magnetic field, has adopted six subcoils, utilizes its radio-frequency (RF) magnetic field separately in the mutual compensation at space overlap place, has improved the spatial uniformity in single coil magnetic field, has improved the Distribution of Magnetic Field of single coil.
5. coil device of the present invention is easy for installation, can directly be used for replacing original coil, and need not change other hardware, compare with traditional coil, this coil has had very big variation in shape, based on the change of shape, in conjunction with above-mentioned explanation, this coil has following characteristics: (1) has improved the radio-frequency power of coil; (2) improved the uniformity of magnetic field of coil; (3) easy to install and use.
Description of drawings
Accompanying drawing 1 is magnetic nuclear resonance analyzer principle schematic of the present invention;
Accompanying drawing 2 is rectangle subcoil structural representation in the radio-frequency coil of the present invention;
Accompanying drawing 3 is radio-frequency coil partial schematic diagram of the present invention;
Accompanying drawing 4 is radio-frequency coil structure synoptic diagram of the present invention.
In the above accompanying drawing: 1, frequency meter; 2, radio-frequency oscillator; 3, radio-frequency coil; 4, modulator receiver; 5, sample hose; 6, rotor fixture; 7, rectangle subcoil; 8, grow the limit; 9, first transmission line; 10, minor face; 11, second transmission line; 12, first magnet; 13, second magnet; 14, closed loop coil.
Embodiment
Below in conjunction with drawings and Examples the present invention is further described:
Embodiment: a kind of nuclear magnetic resonance device for biological medicine shown in accompanying drawing 1 ~ 4, comprising:
Frequency meter 1 is for generation of radio-frequency (RF) pulse signal;
Radio-frequency oscillator 2 produces corresponding pulse current according to the radio-frequency (RF) pulse signal from described frequency meter, and receives the sample feedback signal from radio-frequency coil;
Radio-frequency coil 3, according to the pulse current product alternating electromagnetic field from described radio-frequency oscillator 2, and induction generates the sample feedback signal that characterizes sample nuclear spin energy level, described radio-frequency coil 3 comprises even number rectangle subcoil 7, first transmission line 9 that back formation one is positioned at the axle center is extended on the long limit 8 of one side of this rectangle subcoil 7, extend to form second transmission line 11 after adjacent minor face 10 bendings in long limit 8 therewith, several rectangle subcoils 7 are in parallel and uniformly-spaced arrange and form described radio-frequency coil 3;
Modulator receiver 4 is connected to described radio-frequency oscillator 2, is used for extracting the sample feedback signal from radio-frequency oscillator 2;
The sample hose 5 that is used for the carrying detected sample is positioned on described radio-frequency coil 3 axial lines and is positioned under it, and this sample hose is installed on the rotor fixture 6;
First magnet 12 and second magnet 13 lay respectively at described sample hose 5 both sides, and being used for provides static magnetic field to the sample in this sample hose 5.
Above-mentioned several second transmission line, 11 other end bendings connect by a closed loop coil 14; Above-mentioned rectangle subcoil number is 6, and the adjacent rectangle subcoil is spaced apart 60 degree.
The magnetic field intensity of above-mentioned first magnet 12 and second magnet 13 is 1 ~ 1.2 tesla; Above-mentioned rotor fixture 6 materials are teflon.
When adopting above-mentioned nuclear magnetic resonance device for biological medicine, it is applicable to transmitting and receiving of pulse signal, can be used for the research of high resolution NMR experiment; This apparatus structure is tight, has higher quality factor, and the radio-frequency power that can carry is 30kHz, and the uniformity coefficient of radio-frequency (RF) magnetic field is 4.6%.Realized that high-power exciting and good radio-frequency (RF) magnetic field distribute, and have improved precision and the sensitivity of measuring greatly; Secondly, adopted six groups of leads in the nuclear magnetic resonance device, compared with the Helmholtz coils that is made of two groups of leads with the solenoid type coil that traditional one group of lead constitutes, structure is meticulousr, can realize more complicated radio-frequency field; Again, coil device has been realized high power.Have six subcoils in a coil, total radio-frequency power is distributed to six subcoils.Under the constant situation of each subcoil peak power, improved general power, therefore improved the resolution of imaging; Again, nuclear magnetic resonance device has improved the uniformity coefficient of radio-frequency (RF) magnetic field, has adopted six subcoils, utilizes its radio-frequency (RF) magnetic field separately in the mutual compensation at space overlap place, has improved the spatial uniformity in single coil magnetic field, has improved the Distribution of Magnetic Field of single coil.
Above-described embodiment only is explanation technical conceive of the present invention and characteristics, and its purpose is to allow the personage who is familiar with this technology can understand content of the present invention and enforcement according to this, can not limit protection scope of the present invention with this.All equivalences that spirit essence is done according to the present invention change or modify, and all should be encompassed within protection scope of the present invention.
Claims (5)
1. nuclear magnetic resonance device that is used for biological medicine is characterized in that: comprising:
Frequency meter (1) is for generation of radio-frequency (RF) pulse signal;
Radio-frequency oscillator (2) produces corresponding pulse current according to the radio-frequency (RF) pulse signal from described frequency meter, and receives the sample feedback signal from radio-frequency coil;
Radio-frequency coil (3), produce alternating electromagnetic field according to the pulse current from described radio-frequency oscillator (2), and induction generates the sample feedback signal that characterizes sample nuclear spin energy level, described radio-frequency coil (3) comprises even number rectangle subcoil (7), first transmission line (9) that back formation one is positioned at the axle center is extended on the long limit of one side of this rectangle subcoil (7) (8), extend to form second transmission line (11) after adjacent minor face (10) bending in long limit (8) therewith, several rectangle subcoils (7) are in parallel and uniformly-spaced arrange and form described radio-frequency coil (3);
Modulator receiver (4) is connected to described radio-frequency oscillator (2), is used for extracting the sample feedback signal from radio-frequency oscillator (2);
The sample hose (5) that is used for the carrying detected sample is positioned on described radio-frequency coil (3) axial line and is positioned under it, and this sample hose is installed on the rotor fixture (6);
First magnet (12) and second magnet (13) lay respectively at described sample hose (5) both sides, and being used for provides static magnetic field to the sample in this sample hose (5).
2. nuclear magnetic resonance spectroscopy device according to claim 1, it is characterized in that: described several second transmission line (11) other end bendings connect by a closed loop coil (14).
3. nuclear magnetic resonance spectroscopy device according to claim 1, it is characterized in that: the magnetic field intensity of described first magnet (12) and second magnet (13) is 1 ~ 1.2 tesla.
4. nuclear magnetic resonance spectroscopy device according to claim 1, it is characterized in that: described rectangle subcoil (7) number is 6, adjacent rectangle subcoil (7) is spaced apart 60 degree.
5. nuclear magnetic resonance spectroscopy device according to claim 1, it is characterized in that: described rotor fixture (6) material is teflon.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610445226.1A CN106168589B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high resolution nuclear magnetic resonance analyzer |
| CN201610445178.6A CN106153663B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high sensitivity nuclear magnetic resonance equipment |
| CN201310068814.4A CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310068814.4A CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610445178.6A Division CN106153663B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high sensitivity nuclear magnetic resonance equipment |
| CN201610445226.1A Division CN106168589B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high resolution nuclear magnetic resonance analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103207199A true CN103207199A (en) | 2013-07-17 |
| CN103207199B CN103207199B (en) | 2016-05-18 |
Family
ID=48754486
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610445226.1A Expired - Fee Related CN106168589B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high resolution nuclear magnetic resonance analyzer |
| CN201310068814.4A Expired - Fee Related CN103207199B (en) | 2013-03-05 | 2013-03-05 | For the nuclear magnetic resonance device of biological medicine |
| CN201610445178.6A Expired - Fee Related CN106153663B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high sensitivity nuclear magnetic resonance equipment |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610445226.1A Expired - Fee Related CN106168589B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high resolution nuclear magnetic resonance analyzer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610445178.6A Expired - Fee Related CN106153663B (en) | 2013-03-05 | 2013-03-05 | A kind of biological medicine high sensitivity nuclear magnetic resonance equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (3) | CN106168589B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106483159A (en) * | 2016-11-23 | 2017-03-08 | 青海七彩花生物科技有限公司 | A kind of biological medicine scintilla NMR analysis devices and its analysis method |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108505986A (en) * | 2018-03-09 | 2018-09-07 | 中国石油天然气股份有限公司 | Nuclear magnetic resonance downhole fluid identification device and its downhole fluid identification probe |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4275350A (en) * | 1979-05-29 | 1981-06-23 | Varian Associates, Inc. | Sample spinning mechanism for NMR probes |
| US4329646A (en) * | 1979-05-21 | 1982-05-11 | Hitachi, Ltd. | Impulse resonance spectrometer |
| CN1662824A (en) * | 2002-06-21 | 2005-08-31 | 皇家飞利浦电子股份有限公司 | Magnetic resonance imaging apparatus and method |
| CN203224464U (en) * | 2013-03-05 | 2013-10-02 | 杨晓冬 | Nuclear-magnetic-resonance device for biological medicines |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202712411U (en) * | 2011-11-14 | 2013-01-30 | 西安电子科技大学 | Wideband dual-polarization base station antenna radiation unit |
-
2013
- 2013-03-05 CN CN201610445226.1A patent/CN106168589B/en not_active Expired - Fee Related
- 2013-03-05 CN CN201310068814.4A patent/CN103207199B/en not_active Expired - Fee Related
- 2013-03-05 CN CN201610445178.6A patent/CN106153663B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4329646A (en) * | 1979-05-21 | 1982-05-11 | Hitachi, Ltd. | Impulse resonance spectrometer |
| US4275350A (en) * | 1979-05-29 | 1981-06-23 | Varian Associates, Inc. | Sample spinning mechanism for NMR probes |
| CN1662824A (en) * | 2002-06-21 | 2005-08-31 | 皇家飞利浦电子股份有限公司 | Magnetic resonance imaging apparatus and method |
| CN203224464U (en) * | 2013-03-05 | 2013-10-02 | 杨晓冬 | Nuclear-magnetic-resonance device for biological medicines |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106483159A (en) * | 2016-11-23 | 2017-03-08 | 青海七彩花生物科技有限公司 | A kind of biological medicine scintilla NMR analysis devices and its analysis method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103207199B (en) | 2016-05-18 |
| CN106153663B (en) | 2018-04-10 |
| CN106168589B (en) | 2018-08-17 |
| CN106153663A (en) | 2016-11-23 |
| CN106168589A (en) | 2016-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Sakellariou et al. | High-resolution, high-sensitivity NMR of nanolitre anisotropic samples by coil spinning | |
| Brunner et al. | Travelling-wave nuclear magnetic resonance | |
| CN103069296B (en) | By the B in the nuclear magnetic resonance of nonselective customization RF impulse compensation 1the method and apparatus of inhomogeneities | |
| Hu et al. | Comparison of several hetero-nuclear dipolar recoupling NMR methods to be used in MAS HMQC/HSQC | |
| Fratila et al. | Multinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil | |
| CN1221783C (en) | Magnetic resonance analyzing flow meter and flow measuring method | |
| CN104483641B (en) | Electronic-nuclear double-resonance resonator | |
| Baltisberger et al. | Communication: Phase incremented echo train acquisition in NMR spectroscopy | |
| Rossini et al. | Dynamic nuclear polarisation enhanced 14 N overtone MAS NMR spectroscopy | |
| Manz et al. | A simple, small and low cost permanent magnet design to produce homogeneous magnetic fields | |
| Takeda | Microcoils and microsamples in solid-state NMR | |
| O’Dell et al. | Optimized excitation pulses for the acquisition of static NMR powder patterns from half-integer quadrupolar nuclei | |
| CN102607734B (en) | Temperature measuring method and device based on nuclear magnetic resonance principle | |
| Chudo et al. | Rotational Doppler effect and Barnett field in spinning NMR | |
| Mithu et al. | Heteronuclear dipolar decoupling in solid-state nuclear magnetic resonance under ultra-high magic-angle spinning | |
| CN103207199A (en) | Biomedical nuclear magnetic resonance device | |
| Sun et al. | The twisted solenoid RF phase gradient transmit coil for TRASE imaging | |
| Siegel et al. | Sensitivity enhancement of solid-state NMR spectra of half-integer spin quadrupolar nuclei using hyperbolic secant pulses: Applications to spin-5/2 nuclei | |
| CN203224464U (en) | Nuclear-magnetic-resonance device for biological medicines | |
| Gan et al. | Enhancing MQMAS of low-γ nuclei by using a high B1 field balanced probe circuit | |
| CN203224612U (en) | High-resolution nuclear magnetic resonance analysis device | |
| CN103176153B (en) | High resolution nuclear magnetic resonance analytical equipment | |
| Yamamoto et al. | PITANSEMA-MAS, a solid-state NMR method to measure heteronuclear dipolar couplings under MAS | |
| CN104345073A (en) | Biomedical micro molecular magnetic resonance analytical equipment | |
| Paul et al. | Efficient heteronuclear dipolar decoupling in solid-state nuclear magnetic resonance at rotary resonance conditions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160518 Termination date: 20180305 |