CN106478518A - A kind of preparation method of heptenoic acid ring pentyl ester derivant - Google Patents
A kind of preparation method of heptenoic acid ring pentyl ester derivant Download PDFInfo
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- CN106478518A CN106478518A CN201610853381.7A CN201610853381A CN106478518A CN 106478518 A CN106478518 A CN 106478518A CN 201610853381 A CN201610853381 A CN 201610853381A CN 106478518 A CN106478518 A CN 106478518A
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- pentyl ester
- ring pentyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Abstract
The invention discloses one kind is with (4R cis) 6 [(acetoxyl group) methyl] 2, 2 dimethyl 1, 3 dioxane 4 tert-butyl acetate initiation material, through hydrolysis, replace, the method that heptenoic acid ring pentyl ester product is prepared in the reactions such as oxidation, the synthesis step of the method is brief, intermediate can carry out next step reaction without polishing purification, Butt-coupling reaction replaces ultralow temperature reaction condition with conventional gentle process conditions, replace dangerous high super base simultaneously, improve the safety of reaction, route overall yield is high, it is suitable for scale industrial production.
Description
Technical field
The present invention relates to a kind of preparation method of heptenoic acid ring pentyl ester derivant, specifically, it is related to a kind of Rosuvastain
The preparation method of spit of fland calcium important intermediate.
Background technology
Rosuvastain calcium（Rosuvastatin Calcium）It is Astrazeneca AB in 2002 on Europe obtains
The up-to-date statinses of city's approval, are that media evaluate " superstatin ".For treating constitutional, familial hypercholesterolemia
Disease and mixed type dyslipidemia.It gets the Green Light in the U.S. in August, 2003, thus becomes the 7th coming into the market
Statinses.Its chemical name is：(3R, 5S, 6E) -7- [4- (4- fluorophenyl) -6- isopropyl -2- (N- methyl-N- first sulphur
Amide groups) -5- pyrimidine] -3,5- dihydroxy -6- heptenoic acid calcium.Structure such as formula 1：
Patent EP0521471 reported first rosuvastain calcium and its synthetic route.This route is prepared by witig reaction
Compound containing ethylene linkage, then the reaction such as chiral reducing carbonyl obtains rosuvastain calcium.In route, multiple intermediate need through post
Chromatogram purification, and use poisonous explosive material, it is not suitable for industrialized production.
A kind of improved method is reported in patent WO2000049014.This route is the improvement route of basic patent route,
Although carrying out purification, effect on driving birds is not good by being converted into methylamine salt, it is unfavorable for producing high-quality product.
For this reason, it may be necessary to a kind of new technical scheme is solving above-mentioned technical problem.
Content of the invention
It is an object of the invention to provide one kind is with (4R-cis) -6- [(acetoxyl group) methyl] -2,2- dimethyl -1,3- two
Oxygen six ring -4- tert-butyl acetate initiation material, through hydrolysis, the method that heptenoic acid ring pentyl ester product is prepared in reaction such as replaces, aoxidizes,
The synthesis step of the method is brief, and intermediate can carry out next step reaction without polishing purification, and Butt-coupling reacts with routine
Gentle process conditions replace ultralow temperature reaction condition, replace dangerous high super base simultaneously, improve the safety of reaction,
Route overall yield is high, is suitable for scale industrial production.
The technical solution used in the present invention is：A kind of preparation method of heptenoic acid ring pentyl ester derivant, technology path is：
.
Comprise the following steps that：
The preparation of intermediate I：
(4R-cis) -6- [(acetoxyl group) methyl] -2,2- dimethyl -1,3- dioxane -4- tert-butyl acetate is in base reagent
Be hydrolyzed under catalysis reaction；
The preparation of intermediate II：
Intermediate I, after base reagent catalyzing hydrolysis, carries out substitution reaction with bromocyclopentane under quaternary ammonium salt catalysis, obtains ring penta
Ester intermediate II；
The preparation of intermediate M1：
Under catalyst action, oxidized dose is oxidized to aldehyde compound to intermediate II, and reaction obtains intermediate M1；
The preparation of intermediate III：
Intermediate M1 and [4- [4- fluorophenyl -6- (1- Methylethyl) -2- [N- methyl-(N- mesyl) amino]] -5- pyrimidine
Base] methyl bromide triphenyl phosphorus under base reagent catalyst action, carry out under heating Butt-coupling reaction obtain intermediate III；
The preparation of finished product：
Intermediate III, under acid effect, is sloughed acetonylidene protection and is obtained heptenoic acid ring pentyl ester product.
Preferably, in the preparation process of intermediate I, described (4R-cis) -6- [(acetoxyl group) methyl] -2,2- diformazan
Base -1,3- dioxane -4- tert-butyl acetate and base reagent mol ratio be 1:1.5～1:3.
Preferably, in the preparation process of intermediate I, described base reagent is sodium hydroxide, Lithium hydrate or potassium carbonate；Reaction
Temperature is 5～50 DEG C；Required reaction dissolvent is methanol, ethanol or isopropanol.
Preferably, in the preparation process of intermediate II, the mol ratio 1 of described intermediate I and bromocyclopentane:2～1:5.
Preferably, in the preparation process of intermediate II, described quaternary ammonium salt catalyst is tetrabutyl ammonium bromide or tetrabutyl iodine
Change ammonium；Reaction temperature is 20～80 DEG C；Required reaction dissolvent is acetonitrile, methanol, ethanol or isopropanol.
Preferably, in the preparation process of intermediate M1, described intermediate II is 1 with the mol ratio of oxidant:2～1:5.
Preferably, in the preparation process of intermediate M1, described oxidant is sodium hypochlorite or oxalyl chloride and dimethyl sulfoxide
Compositionss；Required reaction dissolvent is dichloromethane, oxolane or toluene；Described catalyst is tetrabutyl ammonium bromide or the tetrabutyl
Ammonium iodide；Reaction temperature is 20～80 DEG C.
Preferably, in the preparation process of intermediate III, described intermediate M1 and [4- [4- fluorophenyl -6- (1- methyl second
Base) -2- [N- methyl-(N- mesyl) amino]] -5- pyrimidine radicals] and methyl bromide triphenyl phosphorus mol ratio be 1:1～1:
1.5.
Preferably, in the preparation process of intermediate III, described base reagent is potassium carbonate, cesium carbonate or potassium acetate；Required anti-
Answer solvent to be dimethyl sulfoxide, N,N-dimethylformamide or toluene；Reaction temperature is 50～100 DEG C.
Preferably, in the preparation process of finished product, required acid is hydrochloric acid, glacial acetic acid or sulphuric acid；Required reaction dissolvent is acetonitrile
Or oxolane；Reaction temperature is 20～50 DEG C；Intermediate III is 1 with the mol ratio of acid:1.2～1:2.
It is an advantage of the invention that：With (4R-cis) -6- [(acetoxyl group) methyl] -2,2- dimethyl -1,3- dioxy six
Ring -4- tert-butyl acetate initiation material, reacts through hydrolysis, replacement, oxidation etc. and obtains (4R-cis) -6- aldehyde radical -2, and 2- dimethyl -
1,3- dioxane -4- acetic acid cyclopentyl ester, with [4- [4- fluorophenyl -6- (1- Methylethyl) -2- [N- methyl-(N- methylsulfonyl
Base) amino]] -5- pyrimidine radicals] methyl bromide triphenyl phosphorus carry out Butt-coupling, hydrolysis obtains heptenoic acid ring pentyl ester product.Relatively
In prior art route, synthesis step is brief, and intermediate can carry out next step reaction without polishing purification, and Butt-coupling reacts
Replace ultralow temperature reaction condition with conventional gentle process conditions, replace dangerous high super base simultaneously, improve reaction
Safety, route overall yield is high, is suitable for scale industrial production.
Specific embodiment
Embodiment 1：
The synthesis of intermediate I：
500mL methanol, 30g (4R-cis) -6- [(acetoxyl group) methyl] -2,2- dimethyl -1,3- bis- is added in reaction bulb
Oxygen six ring -4- tert-butyl acetate and 27.8g potassium carbonate, stirring and dissolving, react at 20～25 DEG C, TLC monitoring reaction.Reaction
Terminate, add 10mL glacial acetic acid, stirring in reactant liquor, be warming up to and remove methanol under reduced pressure at 45～50 DEG C, be subsequently adding 300mL
Toluene and 200mL water, stirring, standing point liquid；Water layer uses 200mL toluene to extract again, merging organic faciess, anhydrous sodium sulfate drying,
Sucking filtration, filtrate is evaporated to dry at 45～50 DEG C, obtains 28.2g product, this product directly carries out next step reaction.
The synthesis of intermediate II：
Add 28.2g intermediate I, 300mL methanol, stirring and dissolving in reaction bulb, add 10.8g sodium hydroxide, be warming up to 45
～50 DEG C；Insulation reaction is overnight；TLC monitoring reaction；Reaction finishes, and is cooled to 20 DEG C, be slowly added dropwise glacial acetic acid adjust pH=7～
7.5；At 40 DEG C, concentrating under reduced pressure removes to obtain grease.Add 200mL DMF, stirring and dissolving in this grease, be subsequently adding
8.6g potassium carbonate, 2.8g tetrabutyl ammonium bromide, 49.2g bromocyclopentane, insulation reaction at 20～25 DEG C；TLC monitoring reaction；
Reaction finishes, and reactant liquor is poured in 500mL water and 300mL ethyl acetate, stirring layering, and aqueous layer with ethyl acetate extracts
（300mL×2）, combined ethyl acetate layer, use 500mL water washing, anhydrous sodium sulfate drying, 40 DEG C of concentrating under reduced pressure are dry
32.3g grease.This product directly carries out next step reaction.
The synthesis of intermediate M1：
Put into 200mL toluene in reaction bulb, under nitrogen protective condition, add 25.2g oxalyl chloride, be cooled to -70～-80 DEG C,
Deca 18.7g DMSO/50mL toluene mixture.Completion of dropping, insulation reaction 30min；Deca 32.3g intermediate II/200mL
Toluene mixed solution；Completion of dropping, stirs 30min, then Deca 24.2g triethylamine, is then warmed to room temperature reaction, and TLC monitoring is anti-
Should；Reaction finishes, and reactant liquor is poured into stirring in 800mL water, standing point liquid, uses toluene（200mL×2）Extraction, merges organic
Phase, is washed with 500mL sodium dihydrogen phosphate, 500mL water washing respectively, is evaporated to dry that 22.8g oily produces at 50 DEG C
Product.
The synthesis of intermediate III：
Add 68.7g [4- [4- fluorophenyl -6- (1- Methylethyl) -2- [N- methyl-(N- mesyl) ammonia in reaction bulb
Base]] -5- pyrimidine radicals] methyl bromide triphenyl phosphorus, 22.8g intermediate M1,300mL dimethyl sulfoxide, stirring and dissolving；Heat up
To 70～80 DEG C；Add 35.2g potassium carbonate, stirring, be warming up to 70～80 DEG C of incubated overnight；TLC monitoring reaction；Reaction finishes,
Reactant liquor is poured in 800mL saturated aqueous common salt and 1000mL toluene mixture liquid, stirs split-phase, in aqueous phase, add toluene（500mL
×2）Extraction；Combining methylbenzene phase, adds 600mL water washing, and at 45 DEG C, concentrating under reduced pressure removes solvent, obtains the faint yellow crude product of 49.5g.Should
Crude product absolute methanol is warming up to molten clear, the crystallize of lowering the temperature that flows back, sucking filtration, methanol rinse, dries to obtain 44.6g white solid product.
Yield：89%.
The synthesis of finished product：
Add in 44.6g intermediate III, 400mL acetonitrile in reaction bulb, stirring and dissolving, Deca 50mL 1N at 30 DEG C -35 DEG C
HCl solution；Drip and finish, insulation reaction at 30 DEG C～35 DEG C,；TLC monitoring reaction；Reaction finishes, and is down to room temperature, Deca 30mL
1N NaOH, maintains PH=9-10, then removes acetonitrile at 45 DEG C under reduced pressure again, adds 300mL water, uses ethyl acetate（120mL×
2）Extraction, merges organic faciess, and saturated nacl aqueous solution washs, anhydrous sodium sulfate drying, and sucking filtration is evaporated to dry, obtains 43.8g
Crude white solid.This crude product is refined with 220mL isopropanol, obtains 40.1g white solid product.Yield：96%.
Embodiment 2：
The synthesis of intermediate I：
700mL isopropanol, 45g (4R-cis) -6- [(acetoxyl group) methyl] -2,2- dimethyl -1,3- is added in reaction bulb
Dioxane -4- tert-butyl acetate and 12.5g sodium hydroxide, stirring and dissolving, react at 20～25 DEG C, TLC monitoring reaction.
Reaction terminates, and adds 20mL glacial acetic acid, stirring, be warming up at 45～50 DEG C and remove isopropanol, Ran Houjia under reduced pressure in reactant liquor
Enter 500mL ethyl acetate and 300mL water, stirring, standing point liquid；Water layer uses 500mL ethyl acetate to extract again, merges organic faciess,
Anhydrous sodium sulfate drying, sucking filtration, filtrate is evaporated to dry at 45～50 DEG C, obtains 42.3g product, under this product is directly carried out
Single step reaction.
The synthesis of intermediate II：
Add 42.3g intermediate I, 300mL isopropanol, stirring and dissolving in reaction bulb, add 10.3g Lithium hydrate, be warming up to
45～50 DEG C；Insulation reaction is overnight；TLC monitoring reaction；Reaction finishes, and is cooled to 20 DEG C, is slowly added dropwise glacial acetic acid and adjusts pH=7
～7.5；At 40 DEG C, concentrating under reduced pressure removes to obtain grease.Add 400mL DMF, stirring and dissolving in this grease, be subsequently adding
13.2g potassium carbonate, 2g tetrabutylammonium iodide, 49.2g bromocyclopentane, insulation reaction at 20～25 DEG C；TLC monitoring reaction；
Reaction finishes, and reactant liquor is poured in 600mL water and 400mL dichloromethane, stirring layering, and water layer dichloromethane extracts
（300mL×2）, combined dichloromethane layer, use 500mL water washing, anhydrous sodium sulfate drying, 35 DEG C of concentrating under reduced pressure are dry
48.5g grease.This product directly carries out next step reaction.
The synthesis of intermediate M1：
Put into 200mL toluene in reaction bulb, under nitrogen protective condition, add 37.9g oxalyl chloride, be cooled to -70～-80 DEG C,
Deca 28.5g DMSO/50mL toluene mixture.Completion of dropping, insulation reaction 30min；Deca 48.5g intermediate II/200mL
Toluene mixed solution；Completion of dropping, stirs 30min, then Deca 36.3g piperidines, is then warmed to room temperature reaction, and TLC monitoring is anti-
Should；Reaction finishes, and reactant liquor is poured into stirring in 1000mL water, standing point liquid, uses dichloromethane（300mL×2）Extraction, merges
Organic faciess, are washed with 500mL sodium dihydrogen phosphate, 500mL water washing respectively, are evaporated to dry that 34.2g is oily at 35 DEG C
Shape product.
The synthesis of intermediate III：
Add 103.3g [4- [4- fluorophenyl -6- (1- Methylethyl) -2- [N- methyl-(N- mesyl) ammonia in reaction bulb
Base]] -5- pyrimidine radicals] methyl bromide triphenyl phosphorus, 34.2g intermediate M1,500mL DMF, stirring is molten
Solution；It is warming up to 70～80 DEG C；Add 98.3g cesium carbonate, stirring, be warming up to 70～80 DEG C of incubated overnight；TLC monitoring reaction；Instead
Should finish, reactant liquor is poured in 1000mL saturated aqueous common salt and 1500mL toluene mixture liquid, stir split-phase, in aqueous phase, add first
Benzene（500mL×2）Extraction；Combining methylbenzene phase, adds 800mL water washing, and at 45 DEG C, concentrating under reduced pressure removes solvent, obtains 78.5g yellowish
Color crude product.This crude product absolute methanol is warming up to molten clear, the crystallize of lowering the temperature that flows back, sucking filtration, methanol rinse, dries to obtain 65.6g white
Solid product.Yield：88%.
The synthesis of finished product：
Add in 65.6g intermediate III, 800mL oxolane in reaction bulb, stirring and dissolving, Deca at 30 DEG C -35 DEG C
200mL 1N sulfuric acid solution；Drip and finish, insulation reaction at 30 DEG C～35 DEG C,；TLC monitoring reaction；Reaction finishes, and is down to room temperature,
Deca 50mL 1N NaOH, maintains PH=9-10, then removes oxolane at 45 DEG C under reduced pressure again, adds 500mL water, uses acetic acid
Ethyl ester（200mL×2）Extraction, merges organic faciess, and saturated nacl aqueous solution washs, anhydrous sodium sulfate drying, sucking filtration, concentrating under reduced pressure
To dry, obtain 62.3g crude white solid.This crude product is refined with 350mL isopropanol, obtains 58.6g white solid product.
Embodiment 3：
The synthesis of intermediate I：
700mL ethanol, 38g (4R-cis) -6- [(acetoxyl group) methyl] -2,2- dimethyl -1,3- bis- is added in reaction bulb
Oxygen six ring -4- tert-butyl acetate and 6.4g Lithium hydrate, stirring and dissolving, react at 20～25 DEG C, TLC monitoring reaction.Reaction
Terminate, add 15mL glacial acetic acid, stirring in reactant liquor, be warming up to and remove ethanol under reduced pressure at 45～50 DEG C, be subsequently adding 450mL
Toluene and 250mL water, stirring, standing point liquid；Water layer uses 400mL toluene to extract again, merging organic faciess, anhydrous sodium sulfate drying,
Sucking filtration, filtrate is evaporated to dry at 45～50 DEG C, obtains 35.9g product, this product directly carries out next step reaction.
The synthesis of intermediate II：
Add 35.9g intermediate I, 300mL acetonitrile, stirring and dissolving in reaction bulb, add 14.6g sodium hydroxide, be warming up to 45
～50 DEG C；Insulation reaction is overnight；TLC monitoring reaction；Reaction finishes, and is cooled to 20 DEG C, be slowly added dropwise glacial acetic acid adjust pH=7～
7.5；At 40 DEG C, concentrating under reduced pressure removes to obtain grease.Add 300mL DMF, stirring and dissolving in this grease, be subsequently adding
10.3g sodium carbonate, 2g tetrabutyl ammonium bromide, 41.8g bromocyclopentane, insulation reaction at 20～25 DEG C；TLC monitoring reaction；
Reaction finishes, and reactant liquor is poured in 500mL water and 300mL toluene, stirring layering, and water layer toluene extracts（300mL×2）,
Combining methylbenzene layer, uses 500mL water washing, anhydrous sodium sulfate drying, 45 DEG C of concentrating under reduced pressure dry 41.3g grease.This product
Directly carry out next step reaction.
The synthesis of intermediate M1：
In reaction bulb, sequentially add 41.3g intermediate II, 500mL dichloromethane, 100mL water, 1g 2,2,6,6- tetramethyl
Piperidine oxide and 2g potassium bromide, stirring and dissolving, are cooled to -5-0 DEG C, Deca 80g liquor natrii hypochloritises；Drip and finish, be warming up to 15-
20 DEG C of reactions, TLC monitoring reaction；Reaction finishes, and adds 100mL water, stirring, stratification in reactant liquor；Water layer dichloro
Methane（200mL×2）Extraction；Organic layer uses 100mL saturated sodium bisulfite solution, saturated aqueous common salt successively（100mL×2）Wash
Wash, anhydrous sodium sulfate drying, sucking filtration, at 35 DEG C, be evaporated to dry 29.1g oily product.
The synthesis of intermediate III：
Add 87.8g [4- [4- fluorophenyl -6- (1- Methylethyl) -2- [N- methyl-(N- mesyl) ammonia in reaction bulb
Base]] -5- pyrimidine radicals] methyl bromide triphenyl phosphorus, 29.1g intermediate M1,400mL dimethyl sulfoxide, stirring and dissolving；Heat up
To 70～80 DEG C；Add 35.4g potassium carbonate, stirring, be warming up to 70～80 DEG C of incubated overnight；TLC monitoring reaction；Reaction finishes,
Reactant liquor is poured in 800mL saturated aqueous common salt and 1200mL toluene mixture liquid, stirs split-phase, in aqueous phase, add toluene（400mL
×2）Extraction；Combining methylbenzene phase, adds 600mL water washing, and at 45 DEG C, concentrating under reduced pressure removes solvent, obtains the faint yellow crude product of 65.2g.Should
Crude product absolute methanol is warming up to molten clear, the crystallize of lowering the temperature that flows back, sucking filtration, methanol rinse, dries to obtain 57.1g white solid product.
Yield：90%.
The synthesis of finished product：
Add in 57.1g intermediate III, 600mL acetonitrile in reaction bulb, stirring and dissolving, Deca 10g ice vinegar at 30 DEG C -35 DEG C
Acid；Drip and finish, insulation reaction at 30 DEG C～35 DEG C,；TLC monitoring reaction；Reaction finishes, and is down to room temperature, Deca 4mL 1N
NaOH, maintains PH=9-10, then removes acetonitrile at 45 DEG C under reduced pressure again, adds 400mL water, uses ether（200mL×2）Extraction,
Merge organic faciess, saturated nacl aqueous solution washs, anhydrous sodium sulfate drying, sucking filtration is evaporated to dry, obtain 55.8g white solid
Body crude product.This crude product is refined with 300mL isopropanol, obtains 51.2g white solid product.Yield：95%.
Claims (10)
1. a kind of preparation method of heptenoic acid ring pentyl ester derivant it is characterised in that：As follows including step：
The preparation of intermediate I：
(4R-cis) -6- [(acetoxyl group) methyl] -2,2- dimethyl -1,3- dioxane -4- tert-butyl acetate is in base reagent
Be hydrolyzed under catalysis reaction；
The preparation of intermediate II：
Intermediate I, after base reagent catalyzing hydrolysis, carries out substitution reaction with bromocyclopentane under quaternary ammonium salt catalysis, obtains ring penta
Ester intermediate II；
The preparation of intermediate M1：
Under catalyst action, oxidized dose is oxidized to aldehyde compound to intermediate II, and reaction obtains intermediate M1；
The preparation of intermediate III：
Intermediate M1 and [4- [4- fluorophenyl -6- (1- Methylethyl) -2- [N- methyl-(N- mesyl) amino]] -5- pyrimidine
Base] methyl bromide triphenyl phosphorus under base reagent catalyst action, carry out under heating Butt-coupling reaction obtain intermediate III；
The preparation of finished product：
Intermediate III, under acid effect, is sloughed acetonylidene protection and is obtained heptenoic acid ring pentyl ester product.
2. a kind of heptenoic acid ring pentyl ester derivant according to claim 1 preparation method it is characterised in that：Intermediate I
Preparation process in, described (4R-cis) -6- [(acetoxyl group) methyl] -2,2- dimethyl-1,3-dioxane -4- acetic acid uncle
Butyl ester and base reagent mol ratio be 1:1.5～1:3.
3. a kind of heptenoic acid ring pentyl ester derivant according to claim 1 and 2 preparation method it is characterised in that：Middle
In the preparation process of body I, described base reagent is sodium hydroxide, Lithium hydrate or potassium carbonate；Reaction temperature is 5～50 DEG C；Required
Reaction dissolvent is methanol, ethanol or isopropanol.
4. a kind of heptenoic acid ring pentyl ester derivant according to claim 1 preparation method it is characterised in that：Intermediate II
Preparation process in, the mol ratio 1 of described intermediate I and bromocyclopentane:2～1:5.
5. a kind of heptenoic acid ring pentyl ester derivant according to claim 1 or 4 preparation method it is characterised in that：Middle
In the preparation process of body II, described quaternary ammonium salt catalyst is tetrabutyl ammonium bromide or tetrabutylammonium iodide；Reaction temperature be 20～
80℃；Required reaction dissolvent is acetonitrile, methanol, ethanol or isopropanol.
6. a kind of heptenoic acid ring pentyl ester derivant according to claim 1 preparation method it is characterised in that：Intermediate M1
Preparation process in, the mol ratio of described intermediate II and oxidant is 1:2～1:5.
7. a kind of heptenoic acid ring pentyl ester derivant according to claim 1 or 6 preparation method it is characterised in that：Middle
In the preparation process of body M1, described oxidant is sodium hypochlorite or the compositionss of oxalyl chloride and dimethyl sulfoxide；Required reaction dissolvent
For dichloromethane, oxolane or toluene；Described catalyst is tetrabutyl ammonium bromide or tetrabutylammonium iodide；Reaction temperature is 20
～80 DEG C.
8. a kind of heptenoic acid ring pentyl ester derivant according to claim 1 preparation method it is characterised in that：Intermediate III
Preparation process in, described intermediate M1 and [4- [4- fluorophenyl -6- (1- Methylethyl) -2- [N- methyl-(N- mesyl)
Amino]] -5- pyrimidine radicals] methyl bromide triphenyl phosphorus mol ratio be 1:1～1:1.5.
9. a kind of heptenoic acid ring pentyl ester derivant according to claim 1 or 8 preparation method it is characterised in that：Middle
In the preparation process of body III, described base reagent is potassium carbonate, cesium carbonate or potassium acetate；Required reaction dissolvent be dimethyl sulfoxide,
N,N-dimethylformamide or toluene；Reaction temperature is 50～100 DEG C.
10. a kind of heptenoic acid ring pentyl ester derivant according to claim 1 preparation method it is characterised in that：Finished product
In preparation process, required acid is hydrochloric acid, glacial acetic acid or sulphuric acid；Required reaction dissolvent is acetonitrile or oxolane；Reaction temperature is
20～50 DEG C；Intermediate III is 1 with the mol ratio of acid:1.2～1:2.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111548312A (en) * | 2020-06-01 | 2020-08-18 | 雅本化学股份有限公司 | Rosuvastatin calcium tablet and preparation process thereof |
| CN115745764A (en) * | 2022-12-08 | 2023-03-07 | 重庆华森制药股份有限公司 | Preparation method of milobalin intermediate |
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