CN106474633B - Neutron capture treatment system - Google Patents

Neutron capture treatment system Download PDF

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Publication number
CN106474633B
CN106474633B CN201510770609.1A CN201510770609A CN106474633B CN 106474633 B CN106474633 B CN 106474633B CN 201510770609 A CN201510770609 A CN 201510770609A CN 106474633 B CN106474633 B CN 106474633B
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CN
China
Prior art keywords
neutron
movable part
generating unit
neutron generating
door lock
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Active
Application number
CN201510770609.1A
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Chinese (zh)
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CN106474633A (en
Inventor
刘渊豪
陈韦霖
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Neuboron Medtech Ltd
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Neuboron Medtech Ltd
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Publication date
Priority to CN201510770609.1A priority Critical patent/CN106474633B/en
Application filed by Neuboron Medtech Ltd filed Critical Neuboron Medtech Ltd
Priority to CN201710545486.0A priority patent/CN107412962B/en
Priority to CN201710545459.3A priority patent/CN107412961B/en
Priority to CN201710544870.9A priority patent/CN107412960B/en
Priority to CN201710545372.6A priority patent/CN107569781B/en
Priority to JP2018523819A priority patent/JP6830483B2/en
Priority to EP16863521.7A priority patent/EP3357536B1/en
Priority to PCT/CN2016/102332 priority patent/WO2017080344A1/en
Priority to RU2019113042A priority patent/RU2717364C1/en
Priority to EP19187968.3A priority patent/EP3586922B1/en
Priority to TW105217113U priority patent/TWM541312U/en
Publication of CN106474633A publication Critical patent/CN106474633A/en
Application granted granted Critical
Publication of CN106474633B publication Critical patent/CN106474633B/en
Priority to US15/967,727 priority patent/US10898731B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103Treatment planning systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1042X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/109Neutrons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092Details

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
  • Particle Accelerators (AREA)

Abstract

The application provides a kind of neutron capture treatment system, including beam-shaping body, it includes beam entrance, neutron generating unit in beam-shaping body, it is adjacent to the slow body of neutron generating unit, it is enclosed in slow external reflector and beam outlet, neutron generating unit from the incident proton beam of beam entrance with occurring nuclear reaction to produce neutron, slow body will be slow from neutron caused by neutron generating unit, the neutron that reflector will deviate from is back to the slow body to improve epithermal neutron intensity of beam, beam-shaping body includes at least one movable part that can be moved to remote or close neutron generating unit direction, the movable part has first position and the second place, the movable part moves between the first position and the second place, when movable part is located at first position, neutron generating unit can be replaced;When movable part is located at the second place, neutron generating unit can not be replaced.It is convenient that the application neutron generating unit is changed, simple in construction, use flexibly.

Description

Neutron capture treatment system
Technical field
The present invention relates to a kind of neutron capture treatment system, more particularly to a kind of neutron that can change neutron generating unit to catch Obtain treatment system.
Background technology
As the development of atomics, such as the radiation cure such as cobalt 60, linear accelerator, electron beam turn into cancer One of Main Means of disease treatment.But conventional photonic or electronic therapy are limited by radioactive ray physical condition itself, are killing While dead tumour cell, substantial amounts of normal structure in beam approach can also be damaged;Additionally, due to tumour cell to putting The difference of radiation-sensitive degree, traditional radiation therapy is for relatively having the malignant tumour of radiation resistance (such as:Multirow glioblast Knurl (glioblastoma multiforme), melanocytoma (melanoma)) treatment effect it is often bad.
In order to reduce the radiation injury of tumour surrounding normal tissue, the target therapy in chemotherapy (chemotherapy) Concept is just applied in radiation cure;And for the tumour cell of radiation resistance, also actively development has high phase at present To biological effect (relative biological effectiveness, RBE) radiation source, as proton therapeutic, heavy particle are controlled Treatment, neutron capture treatment etc..Wherein, neutron capture treatment be combine above two concept, as boron neutron capture treatment, by Boracic medicine gathers in the specificity of tumour cell, coordinates accurately neutron beam regulation and control, there is provided more more preferable than conventional radiation Treatment of cancer selects.
In the treatment of accelerator boron neutron capture, the neutron for nuclear reaction to occur with proton beam and produces neutron beam produces Portion need to be subjected to the irradiation of accelerating proton and it is activation can produce a certain degree of damage, and neutron generating unit is to caused neutron The quality of beam has very important influence, must periodic replacement in order to reduce influence of the neutron generating unit to neutron beam quality Neutron generating unit.
However, it is mostly cylinder that accelerator boron neutron capture of the prior art, which treats slow body, neutron generating unit is led to It is normally placed in the slow body of certain depth, when neutron generating unit, which is damaged, to be needed to change, it is necessary to take more multiple steps Disassembled, this may result in more changing jobs for neutron generating unit and is not easy to carry out.
Therefore, it is necessary to provide a kind of new technical scheme in fact to solve the above problems.
The content of the invention
In order to solve the above problems, a kind of neutron capture treatment system of one aspect of the present invention offer, including beam are whole Body, the beam-shaping body include beam entrance, the neutron generating unit in beam-shaping body, are adjacent to neutron generating unit Slow body, be enclosed in neutron generating unit and slow external reflector and beam outlet, the neutron generating unit with described in Nuclear reaction occurs for the incident proton beam of beam entrance to produce neutron, and the slow body will be from caused by the neutron generating unit Sub slow, the neutron that the reflector will deviate from is back to the slow body to improve epithermal neutron intensity of beam, the beam Shaping body include it is at least one can to away from or the movable part that move close to neutron generating unit direction, the movable part is the Moved between one position and the second place, when movable part is located at first position, neutron generating unit can be replaced;Work as movable part During positioned at the second place, when movable part is located at the second place, neutron generating unit can not be replaced.
Further, for the ease of the replacing of neutron generating unit, as one kind preferably, the movable part reflects for part Body or partial reflector and the combination of the slow body in part.
Further, for the ease of the taking-up of neutron generating unit, the movable part has symmetrical plane, the movable part edge The symmetrical plane is symmetrical, and the neutron generating unit has axis, and the symmetrical plane of the movable part passes through the neutron generating unit Axis, the reflector has first straight line height, and the movable part has second straight line height, neutron generating unit tool There is the 3rd straight line height, the second straight line is highly less than or equal to first straight line height and is more than the 3rd straight line height.
Further, when the second straight line of the movable part is highly equal to the first straight line height of reflector, if living Faying face between moving part and reflector is the connection between plane and plane, is produced during underway sub- capture treatment Radiation will be revealed by the faying face, preferably the reflector has first connecting portion as a kind of, and described first connects Socket part has the first joint face and the first faying face, and the movable part has a second connecting portion, and the second connecting portion has the Two joint faces and the second faying face, when the second straight line of movable part is highly more than neutron less than the first straight line height of reflector During the 3rd straight line height of generating unit, the first joint face of the reflector overlaps with the first faying face, and the of the movable part Two joint faces overlap with the second faying face, the first faying face connection of the second faying face of the movable part and reflector and with institute Any one plane where adding neutron generating unit axis is stated to overlap.
Further, the reflector has first connecting portion, and the first connecting portion has the first joint face and first Faying face, the movable part have second connecting portion, and the second connecting portion has the second joint face and the second faying face, works as institute When stating the second straight line of movable part highly equal to the first straight line height of reflector, first joint face and the first faying face connect Connect but be located at Different Plane, second joint face is connected with the second faying face but is located at Different Plane, first joint face It is connected with the second joint face, the first faying face is connected with the second faying face.
Further, the neutron capture treatment system also includes drive component, and the drive component includes carrying activity The door lock of part and allow door lock to away from or close to the guide rail that moves of neutron generating unit direction, the door lock is along guide rail to remote Or close to the motion of the direction of beam-shaping body, when door lock away from beam-shaping body direction to when moving, the movable part is to remote Move in direction from neutron generating unit;When door lock close to the direction of beam-shaping body to when moving, the movable part is in The direction motion of sub- generating unit.
Further, the guide rail is external located at beam-shaping, and the drive component also includes support frame, support frame as described above One end support door lock other end moved in guide rail, the door lock with support frame move along the rail and to remote or close The direction motion of beam-shaping body.
Further, the neutron capture treatment system also includes drive component, and the drive component includes door lock and branch Support door lock and the tumbler for allowing door lock to rotate, the door lock supports movable part, described when door lock is rotated up around tumbler Movable part moves to close to the direction of neutron generating unit;When door lock rotates down around tumbler, the movable part is to away from The direction motion of sub- generating unit.
Further, the neutron capture treatment system that is used for also includes drive component, and the drive component includes first Connecting rod, second connecting rod and the third connecting rod for connecting first, second connecting rod, it is external that the first connecting rod is fixed on beam-shaping, institute The one end for stating second connecting rod is fixed on the movable part other end and is connected to first connecting rod, and the first connecting rod drives third connecting rod fortune Dynamic, third connecting rod drives second connecting rod motion so that movable part moves to the direction away from or close to neutron generating unit.
Further, when the second straight line of the movable part is highly more than less than the first straight line height of the reflector The 3rd straight line height of neutron generating unit, the reflector is interior to be provided with guide rail, and the movable part is installed in beam-shaping body simultaneously It can be moved along guide rail to the direction away from or close to neutron generating unit.
Compared with prior art, the application has the advantages that:The application can be to remote or lean on by setting The movable part of nearly neutron generating unit direction motion, is easy to the replacing of neutron generating unit, simple in construction, use flexibly.
Brief description of the drawings
Fig. 1 is the schematic diagram of the application neutron capture treatment system;
Fig. 2 a the application movable part is located at the schematic diagram of the second place;
Fig. 2 b are the schematic diagrames that the application movable part is located at first position;
Fig. 3 a be the herein described faying face of movable part second and reflector the first faying face connection and with the neutron The schematic diagram that plane where the axis of generating unit overlaps;
Fig. 3 b are sectional view of the application movable part along symmetrical plane A;
The schematic diagram that Fig. 4 a are the first joint faces of reflector and the inclined angle of the first faying face is set;
Fig. 4 b are the groove surface of the movable part schematic diagrames mutually chimeric with the raised face of reflector;
Fig. 5 a are that piecemeal activity part is embedded the schematic diagram in door lock;
Fig. 5 b are the schematic diagrames that drive component has support frame;
Fig. 6 is the schematic diagram of the embodiment of the present application two;
Fig. 7 is the schematic diagram of the embodiment of the present application three;
Fig. 8 is the schematic diagram of the embodiment of the present application four.
Embodiment
A kind of application of the neutron capture treatment as means of effective treating cancer in recent years gradually increases, wherein with boron Neutron capture treatment is most commonly seen, and the neutron of supply boron neutron capture treatment can be supplied by nuclear reactor or accelerator.This Shen By taking the treatment of accelerator boron neutron capture as an example, the basic module of accelerator boron neutron capture treatment generally includes to use embodiment please It is whole in accelerator, neutron generating unit and the hot removal system and beam accelerated to charged particle (such as proton, deuteron) Body, wherein accelerate the effect of charged particle and metal neutron generating unit to produce neutron, according to required neutron yield rate and energy, can The acceleration charged particle energy of offer and size of current, the characteristic such as materialization of metal neutron generating unit are anti-to select suitable core Should, the nuclear reaction often to come into question has7Li(p,n)7Be and9Be(p,n)9B, both reactions are all the endothermic reaction.Two kinds of nuclear reactions Energy threshold be respectively 1.881MeV and 2.055MeV, because the preferable neutron source of boron neutron capture treatment is keV energy etc. The epithermal neutron of level, if being only slightly taller than the proton bombardment lithium metal neutron generating unit of threshold values using energy in theory, can produce phase To the neutron of low energy, clinic can be used for by being not necessary to too many slow processing, but in two kinds of lithium metal (Li) and beryllium metal (Be) Sub- generating unit and the proton-effect section of threshold values energy be not high, to produce sufficiently large neutron flux, generally from higher-energy Proton trigger nuclear reaction.
Preferable neutron generating unit should possess high neutron yield rate, the distribution of caused neutron energy close to epithermal neutron energy area, Without it is too many wear by force radiation produce, the characteristic such as cheap easily operated and high temperature resistant of safety, but actually and can not find meet it is all It is required that nuclear reaction.In boron neutron capture therapeutic process, neutron generating unit, must due to being impacted, radiating by accelerating proton It can so be damaged, and neutron generating unit has very big influence to the quality of neutron beam caused by beam-shaping body, so Periodically or neutron generating unit is changed according to the damage situations of neutron generating unit and just seem necessary, be described below one Kind can change the neutron capture treatment system of neutron generating unit.
Fig. 1 is the schematic diagram of the application neutron capture treatment system 100.The neutron capture treatment system 100 includes penetrating Beam shaping body 10 and drive component 20.
The beam-shaping body 10 includes beam entrance 11, neutron generating unit 12, is adjacent to the slow of neutron generating unit 12 Body 13, it is enclosed in neutron generating unit 12 and the reflector 14 outside slow body 13 and beam outlet 15.The neutron generating unit 12 with Nuclear reaction occurs for the proton beam incident from the beam entrance 11 to produce neutron, and the slow body 13 from the neutron to producing Neutron caused by portion 12 carry out it is slow, the neutron that the reflector 14 will deviate from back to the slow body 13 with improve it is superthermal in Sub-beam intensity.
The reflector 14 includes at least one activity that can be moved to the remote or close direction of neutron generating unit 12 Part 16.The movable part 16 has first position L1 and second place L2 (with reference to Fig. 2 a and Fig. 2 b), and the movable part 16 is at this Moved between first position L1 and second place L2, when movable part 16 is located at first position L1, neutron generating unit 12 can be by Change;When movable part 16 is located at second place L2, neutron generating unit 12 can not be replaced.Specifically, when the activity Part 16 to the direction away from neutron generating unit 12 move to first position L1 when, neutron generating unit 12 is revealed from beam-shaping body 10 Go out, take out neutron generating unit 12 and neutron generating unit 12 is changed;When the neutron generating unit 12 more finished changing is installed on beam After in shaping body 10, the movable part 16 moves to second place L2 (movable parts 16 to close to the direction of neutron generating unit 12 The periphery of neutron generating unit 12 is coated on, neutron generating unit 12 can not be replaced), should in follow-up neutron capture therapeutic process Movable part 16 leads back to the neutron of deviation with reflector 14 jointly.
The movable part 16 can be partial reflector or partial reflector and the combination of the slow body in part.Movable part 16 Refer to that neutron generating unit 12 is arranged on the front of slow body 13 and enveloped by reflector 14 for the situation of partial reflector, slow body 13 abut against the rear of neutron generating unit 12, as long as partial reflector now is arranged into mobilizable structure (i.e. movable part), By movable part away from changing neutron generating unit.Movable part 16 is that the situation of the slow body combination of partial reflector and part is Refer to, the front that the part of neutron generating unit 12 is located at slow body 13 is coated by reflector 14, and a part is embedded in slow body 13 It is middle to be coated by slow body 13, it is now in order to change neutron generating unit 12, the part being coated on outside neutron generating unit 12 is anti- The slow body of beam and part is arranged to mobilizable structure (i.e. movable part), so as to realize the replacing of neutron generating unit 12.
With reference to Fig. 3 a and Fig. 3 b, for the ease of the replacing of neutron generating unit 12, as one kind preferably, the movable part 16 For symmetrical member, the symmetrical member has symmetrical plane A, and movable part 16 is symmetrical along symmetrical plane A, and the symmetrical plane A passes through institute The axis I of neutron generating unit 12 is stated, the reflector 14 has first straight line height H1, and the movable part 16 has second straight line Height H2, the neutron generating unit 12 have the 3rd straight line height H3, the second straight line height H2 of the movable part 16 be less than or Person is equal to the first straight line height H1 of reflector 14 and is more than the 3rd straight line height H3 of the neutron generating unit 12.
With reference to Fig. 4 a and Fig. 4 b, the reflector 14 also has first connecting portion 140, and the movable part 16 has second to connect Socket part 160.The first connecting portion 140 has the first joint face 141 and the first faying face being connected with the first joint face 141 142, the second connecting portion 160 has the second joint face 161 and the second faying face 162 being connected with the second joint face 161.
It is more than described when the second straight line height H2 of the movable part 16 is less than the first straight line height H1 of reflector 14 During the 3rd straight line height H3 of neutron generating unit 12, the first joint face 141 and the weight of the first faying face 142 of the reflector 14 Close, the second joint face 161 of the movable part 16 overlaps with the second faying face 162, the second faying face 162 of the movable part 16 It is connected with the first faying face 142 of reflector 14 and is overlapped with any one plane where the axis of the neutron generating unit 12 (such as Fig. 3 a).Now the movable part 16 be reflector 14 a part, in this case, when the movable part 16 to When direction away from neutron generating unit 12 moves to first position L1, movable part 16 forms breach on the reflector 14, institute State neutron generating unit 12 from the breach to expose, neutron generating unit 12 is changed in the indentation, there;When the movable part 16 to When moving to second place L2 close to the direction of neutron generating unit 12, the movable part 16 is enclosed in the neutron generating unit 12 Periphery, movable part 16 leads back to the neutron of deviation with reflector 14 jointly in follow-up neutron capture therapeutic process.
When the second straight line height H2 of the movable part 16 is equal to the first straight line height H1 of reflector 14, the activity Part 16 is the half for the reflector 14 for being enclosed in the periphery of neutron generating unit 12.In order to reduce in follow-up neutron capture therapeutic process In the particle that is leaked from the junction of movable part 16 and reflector 14 or radiation, as it is a kind of preferably, the reflector 14 The first joint face 141 and the first faying face 142 be located at Different Plane, the second joint face 161 and second of the movable part 16 Faying face 162 is located at Different Plane, and first joint face 141 is bonded with the second joint face 161, the first faying face 142 and Two faying faces 162 are bonded.First connecting portion 140 specific as follows can be set (with reference to Fig. 4 a) with second connecting portion 160, the second connection 161 and second faying face of face, 162 inclined angle is set, and first faying face 142 is set with 141 inclined angle of the first joint face Put, both of the aforesaid inclination angle and be 180 degree.Second described in when movable part 16 is enclosed in the periphery of the neutron generating unit 12 Faying face 162 is bonded with the first faying face 142, and the second joint face 161 is bonded with the first joint face 141.First connecting portion 140 with Second connecting portion 160 can also set (with reference to Fig. 4 b) as follows, and second faying face 162 is recessed from the second joint face 161 Groove surface, first faying face 142 be from the first joint face 141 protrude raised face, when movable part 16 be enclosed in it is described in Groove surface and raised face are mutually chimeric during the periphery of sub- generating unit 12.
The structure of drive component 20 is introduced in detail below, in addition, because having been carried out above to the structure of movable part 16 detailed It is thin to introduce, hereafter just it is not repeated to describe, can be according to real needs by the knot of above-mentioned movable part 16 in actual application Structure is combined with drive component 20 described below, although and being to have two movable parts with reflector in Examples below Exemplified by illustrate, but if in actual application set a movable part 16 if can be easy to neutron generating unit 12 Change, then a movable part is set.
Shown in Fig. 2 a and Fig. 2 b and embodiments herein one, the embodiment are that have two with reflector 14 to be located at Carried out exemplified by the both sides of neutron generating unit 12 and the movable part 16 (i.e. the first movable part 163 and the second movable part 164) interconnected Introduce.The drive component 20 includes the door lock 22 of the guide rail 21 and support movable part 16 outside beam-shaping body 10, described Door lock 22 is moved in guide rail 21 to drive movable part 16 to be moved to the direction away from or close to neutron generating unit 12.Movable part 16 include the first movable part 163 and the second movable part 164, and the door lock 22 includes the He of the first door lock 221 moved along guide rail 21 Second door lock 222, first door lock 221 support the first movable part 163, and second door lock 222 supports the second movable part 164.The door lock 222 of first door lock 221 and second is moved in guide rail 21 drives first movable part 163 and second respectively Movable part 164 moves to the direction away from or close to neutron generating unit 12.When the first door lock 221 and the second door lock 222 are distinguished When moving to first position L1 to the direction away from beam-shaping body 10, the movable part 164 of the first movable part 163 and second Moved respectively to the direction away from neutron generating unit 12, now neutron generating unit 12 is exposed from beam-shaping body 10, to neutron Generating unit 12 is changed;When the first door lock 221 and the second door lock 222 move to close to the direction of neutron generating unit 12 respectively During the L2 of the second place, the movable part 164 of the first movable part 163 and second also moves directly to close to the direction of neutron generating unit 12 The periphery of neutron generating unit 12 is coated on to the first movable part 163 and the second movable part 164, in follow-up neutron capture therapeutic process Described in the first movable part 163 and the second movable part 164 be used for the neutron that leads back to deviation.
For the ease of structure design, as one kind preferably, the knot of the movable part 164 of the first movable part 163 and second Structure is identical, and first door lock 221 is identical with the structure of the second door lock 222, infra for being easy to introduce, with general designation activity Part 16 and door lock 22 are introduced.
The structure of the door lock 22 can have a many kinds, in the present embodiment, the second straight line height H2 of the movable part 16 Equal to reflector 14 first straight line height H1 when, door lock 22 is coated on the periphery of movable part 16, it can be understood as movable part 16 It is entrenched in door lock 22, motion of the door lock 22 in guide rail 21 is equivalent to the open and close movement of door lock 22, the movable part 16 With the remote or close neutron generating unit 12 of the folding of door lock 22.As one kind preferably, the door lock 22 is made up of concrete. Certainly, in order to save space or cost, the even less part of the half of movable part 16 can also be embedded in door lock 22 (with reference to Fig. 5 a), if door lock 22 is designed to support the movable part 16, and movable part 16 can be driven to remote or Close to the motion of the direction of neutron generating unit 12.When the second straight line height H2 of movable part 16 is less than the first straight of reflector 14 Support frame 23 (with reference to Fig. 5 b) can also be set during line height between door lock 22 and guide rail 21.One end of support frame as described above 23 with Door lock 22 is fixed, and the other end moves in guide rail 21 to the direction away from or close to beam-shaping body 10.The movable part 16 Moved with the motion of door lock 22 along guide rail 21 to the direction away from or close to neutron generating unit 12.That is, the door lock 22 by support frame 23 in guide rail 21 motion drive door lock 22 move it is sufficiently large to avoid the need for door lock 22 being arranged to Size makes it directly be moved in guide rail 21, so as to reduce the size of door lock 22.
Fig. 6 show the schematic diagram of the embodiment of the present application two.The drive component 20 include tumbler 24 (such as shaft member) and The door lock 22 ' being immobilizated on tumbler 24.The tumbler 24 is located at the underface of beam-shaping body 10 and the tumbler 24 Axis and the neutron generating unit 12 diameter parallel.The door lock 22 ' rotates upwardly and downwardly around tumbler 24, when the door lock 22 ' when moving downward, and the door lock 22 ' drives movable part 16 move to the direction away from neutron generating unit 12, and the neutron produces Life portion 12 exposes, and changes neutron generating unit 12;When door lock 22 ' is rotated up, movable part 16 is driven to close to neutron generating unit 12 direction rotates, and the movable part 16 is enclosed in the periphery of neutron generating unit 12, is used in follow-up neutron capture therapeutic process Lead back to the neutron of deviation.
Fig. 7 is the schematic diagram that the application implements three.Drive component 20 described in the present embodiment includes being fixed on beam-shaping First connecting rod 25 outside body 10, the second connecting rod 26 for being connected to movable part 16 and connection first connecting rod 25 and second connecting rod 26 Third connecting rod 27, the third connecting rod 27 motion drive second connecting rod 26 to move, the movable part 16 with second connecting rod 26 fortune Direction motion of the trend away from or close to neutron generating unit 12.
Fig. 8 is the schematic diagram of the embodiment of the present application four.When the second straight line height H2 of movable part 16 is less than the reflector (especially when the second straight line height H2 of movable part 16 is more than the 3rd straight line of neutron generating unit 12 during 14 first straight line height H1 During height H3), guide rail 28 can be set in reflector 14, and handle 165 is set in the outside wall surface of movable part 16, pass through push-and-pull Handle 165 drives movable part 16 to be moved along guide rail 28 to the direction away from or close to neutron generating unit 12.It is of course also possible to will Drive component in above-described embodiment one to embodiment three applies in the present embodiment herein just in detail not be situated between to substitute handle Continue.
The neutron capture treatment system that the application discloses is not limited to the content described in above example and accompanying drawing institute The structure of expression.The apparently change made on the basis of the application to the material of wherein component, shape and position, replace Generation or modification, all this application claims within the scope of.

Claims (6)

1. a kind of neutron capture treatment system, including beam-shaping body, it is characterised in that:The beam-shaping body enters including beam Mouth, the neutron generating unit in beam-shaping body, the slow body for being adjacent to neutron generating unit, it is enclosed in neutron generating unit and eases up The external reflector of speed and beam outlet, the neutron generating unit from the incident proton beam of the beam entrance with occurring nuclear reaction To produce neutron, the neutron generating unit has axis, and the slow body will be slow from neutron caused by the neutron generating unit, The neutron that the reflector will deviate from is back to the slow body to improve epithermal neutron intensity of beam, the beam-shaping body bag At least one movable part that can be moved to remote or close neutron generating unit direction is included, the movable part have first position And the second place, the movable part move between the first position and the second place, when movable part is located at first position, in Sub- generating unit can be replaced;When movable part is located at the second place, neutron generating unit can not be replaced, and the movable part is Partial reflector or partial reflector and the combination of the slow body in part, the reflector have perpendicular to axis direction and work The first straight line height of the moving part direction of motion, the movable part have the perpendicular to axis direction and the movable part direction of motion Two straight lines height, the neutron generating unit have perpendicular to axis direction and the 3rd straight line of movable part direction of motion height, When the second straight line of the movable part is highly more than the 3rd of neutron generating unit less than the first straight line height of the reflector Straight line height, is provided with guide rail in the reflector, and the movable part is installed in beam-shaping body and can be along guide rail to remote Or close to the motion of the direction of neutron generating unit.
2. neutron capture treatment system according to claim 1, it is characterised in that:The movable part has symmetrical plane, The movable part is symmetrical along the symmetrical plane, and the neutron generating unit has axis, and the symmetrical plane of the movable part passes through institute State the axis of neutron generating unit.
3. neutron capture treatment system according to claim 1, it is characterised in that:The neutron capture treatment system is also wrapped Drive component is included, the drive component includes the door lock of carrying movable part and allows door lock to remote or close neutron generating unit The guide rail of direction motion, the door lock are moved along guide rail to the direction away from or close to beam-shaping body, when door lock is to remote When beam-shaping body direction is moved, the movable part moves to the direction away from neutron generating unit;When door lock is whole to close beam During the direction motion of body, the movable part moves to close to the direction of neutron generating unit.
4. neutron capture treatment system according to claim 3, it is characterised in that:The guide rail is located at beam-shaping body Outside, when the second straight line of movable part is highly less than the first straight line height of reflector, the drive component also includes support frame, One end support door lock other end of support frame as described above moves in guide rail, the door lock with support frame move along the rail and to remote From or close to beam-shaping body direction motion.
5. neutron capture treatment system according to claim 1, it is characterised in that:The neutron capture treatment system is also wrapped Include drive component, the tumbler that the drive component includes door lock and supports door lock and allow door lock to rotate, the door lock support Movable part, when door lock is rotated up around tumbler, the movable part moves to close to the direction of neutron generating unit;When door lock around When tumbler rotates down, the movable part moves to the direction away from neutron generating unit.
6. neutron capture treatment system according to claim 1, it is characterised in that:It is described to be used for neutron capture treatment system Also include drive component, the drive component includes first connecting rod, second connecting rod and the 3rd company for connecting first, second connecting rod Bar, the first connecting rod are fixed on that beam-shaping is external, and one end of the second connecting rod is fixed on the movable part other end and is connected to Third connecting rod, the first connecting rod drive third connecting rod motion, and third connecting rod drives second connecting rod motion so that movable part Moved to the direction away from or close to neutron generating unit.
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CN201710545372.6A CN107569781B (en) 2015-11-12 2015-11-12 Neutron capture therapy system
CN201510770609.1A CN106474633B (en) 2015-11-12 2015-11-12 Neutron capture treatment system
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PCT/CN2016/102332 WO2017080344A1 (en) 2015-11-12 2016-10-18 Neutron capture therapy system
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101521981A (en) * 2008-02-27 2009-09-02 住友重机械工业株式会社 Target recovery device
CN102946944A (en) * 2010-04-13 2013-02-27 瓦里安医疗系统公司 Radiation treatment systems
CN103052425A (en) * 2010-09-01 2013-04-17 住友重机械工业株式会社 Neutron beam irradiation system
TW201438788A (en) * 2013-03-29 2014-10-16 Sumitomo Heavy Industries Neutron capture therapy device

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4827054B2 (en) * 2006-03-08 2011-11-30 三菱重工業株式会社 Neutron generator and neutron irradiation system
CN107661577B (en) * 2014-12-08 2019-12-13 南京中硼联康医疗科技有限公司 Beam shaping body for neutron capture therapy
CN205235192U (en) * 2015-11-12 2016-05-18 南京中硼联康医疗科技有限公司 Neutron capture treatment system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101521981A (en) * 2008-02-27 2009-09-02 住友重机械工业株式会社 Target recovery device
CN102946944A (en) * 2010-04-13 2013-02-27 瓦里安医疗系统公司 Radiation treatment systems
CN103052425A (en) * 2010-09-01 2013-04-17 住友重机械工业株式会社 Neutron beam irradiation system
TW201438788A (en) * 2013-03-29 2014-10-16 Sumitomo Heavy Industries Neutron capture therapy device

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