CN106474608B - The method of adjustment and ventilator of ventilator based on breathing sleep event - Google Patents
The method of adjustment and ventilator of ventilator based on breathing sleep event Download PDFInfo
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- CN106474608B CN106474608B CN201610861972.9A CN201610861972A CN106474608B CN 106474608 B CN106474608 B CN 106474608B CN 201610861972 A CN201610861972 A CN 201610861972A CN 106474608 B CN106474608 B CN 106474608B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/42—Rate
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Abstract
The present invention relates to the method for adjustment and ventilator of a kind of ventilator based on breathing sleep event, the method for adjustment of the ventilator based on breathing sleep event includes: to acquire the data on flows and pressure data of ventilator；Sleep-respiratory event whether occurs according to the data on flows and pressure data analysis user, when sleep-respiratory event occurs for user, determines the type of the sleep-respiratory event；The parameter of the ventilator is adjusted according to scheduled adjustment mode corresponding with the type of the sleep-respiratory event.The present invention can accurately detect the type whether user currently occurs sleep-respiratory event and the sleep-respiratory event occurred, and can make corresponding adjustment to the parameter of ventilator according to the type of sleep-respiratory event, improve the user experience.
Description
Technical field
The present invention relates to technical field of medical equipment more particularly to a kind of adjustment of the ventilator based on breathing sleep event
Method and ventilator.
Background technique
People, in case of sleep-respiratory event (such as apnea occurs), is easy to influence user during sleep
Sleep quality, in some instances it may even be possible to will cause irremediable consequence.Ventilator can be by adjusting Positive Airway Pressure pressure, and then beats
Open the air flue of user, auxiliary user breathes so that user breathed in sleep it is smooth.Although proposing one in the prior art
The scheme of a little detection sleep-respiratory events, but only specific certain sleep-respiratory events are detected, so that application exists
Certain limitation.The diversity of limitation and sleep-respiratory event in view of technology, current ventilator can not be accurately detected
The sleep-respiratory event of user also can not make corresponding response, poor user experience for each sleep-respiratory event.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of methods of adjustment of ventilator based on breathing sleep event
And ventilator.
The technical scheme to solve the above technical problems is that a kind of tune of the ventilator based on breathing sleep event
Adjusting method, the method for adjustment based on the ventilator for breathing sleep event include:
S1 acquires the data on flows and pressure data of ventilator；
Whether S2 occurs sleep-respiratory event according to the data on flows and pressure data analysis user, occurs in user
When sleep-respiratory event, the type of the sleep-respiratory event is determined；
S3 adjusts the ginseng of the ventilator according to scheduled adjustment mode corresponding with the type of the sleep-respiratory event
Number.
Preferably, the step S2 includes:
S21 generates the corresponding flow curve of the data on flows and the corresponding pressure curve of the pressure data, right respectively
The flow curve and pressure curve are filtered；
S22, in flow curve after the filtering, if the flow value is 0 in the first preset time, it is determined that Yong Hufa
Raw apnea；
S23, if the amplitude of the flow value be reduced to the first default amplitude hereinafter, and the amplitude of the flow value be reduced to
First default amplitude time below continue the second preset time, in second preset time at least twice breathing and
The amplitude of the flow value is restored in third preset time to normal amplitude, it is determined that 1 low pass gas event occurs for user；
S24, the amplitude if the flow value be reduced to the first default amplitude or more and in the second default amplitude hereinafter, if really
Determine user and the relevant microarousal event of respiratory effort occurs, wherein the first default amplitude is less than the described second default amplitude；
S25 in pressure curve after the filtering, obtains the pressure value in the 4th preset time and is greater than the first preset pressure threshold
The set of the crest value of value, and collection of the pressure value less than the valley value of the second preset pressure threshold value in the 4th preset time
It closes, if the quantity of the element in the set of the crest value and the element in the set of the valley value is all larger than preset quantity threshold
Value, alternatively, being equal to if the quantity of the element in the set of the crest value and the element in the set of the valley value is respectively less than
Preset quantity threshold value, and each element in the set of the crest value is all larger than third preset pressure threshold value or the trough
Each element in the set of value is respectively less than the 4th preset pressure threshold value, it is determined that sound of snoring event occurs for user.
Preferably, judge that the step of apnea occurs for user further comprises in the step S22:
Calculate the kurtosis factor of filtered flow curve and the kurtosis factor of filtered pressure curve；
If the difference of the kurtosis factor of the kurtosis factor and pressure curve of flow curve is not more than preset threshold, user's hair
Obstructive type apnea is given birth to, otherwise user's center of origin type apnea.
Preferably, the step S3 includes:
When obstructive type apnea or maincenter type apnea occur for user, when obtaining user's eupnea
Respiratory rate B and air-breathing expiratory duration ratio R, air-breathing is calculated according to the respiratory rate B and air-breathing expiratory duration ratio R and is exhaled
Gas time ratios Rie, 1.2 times of the respiratory rate when respiratory rate of ventilator to be adjusted to user's eupnea, according to suction
Gas expiratory duration ratio R ie provides machine control ventilation, while adjusting the pressure of ventilator in the following way: if when the 5th is default
It is interior that obstructive type apnea at least twice occurs, then in a linear fashion by the pressure of inspiration(Pi) of the ventilator and expiration
Pressure increases at least 1cm H respectively2O；
In the 6th preset time, if at least 3 low pass gas events occur by user or 1 low pass gas thing occurs for user
The relevant microarousal event of 5 respiratory efforts occurs for part and 1 secondary stricture type apnea or user, then pre- the 7th
If breath pressure is increased at least 1cm H in a linear fashion in the time2O；
It is default the 9th if at least sound of snoring event has occurred there are two the respiratory cycle in user in the 8th preset time
Breath pressure is increased at least 1cm H in a linear fashion in time2O。
Preferably, described that air-breathing expiratory duration ratio is calculated according to the respiratory rate B and air-breathing expiratory duration ratio R
The step of Rie includes:
Pressure of inspiration(Pi) is calculated according to the respiratory rate B and air-breathing expiratory duration ratio R, and time Ti:Ti=(60/ (1 is provided
+R))/1.2B；
Time Ti and respiratory rate B is provided according to the pressure of inspiration(Pi), and breath pressure offer time Te:Te=60/ is provided
1.2B-Ti；
Calculate the air-breathing expiratory duration ratio R ie=Ti/Te.
The technical solution that the present invention solves above-mentioned technical problem is also as follows: a kind of ventilator, the ventilator include:
Acquisition module, for acquiring the data on flows and pressure data of ventilator；
Determining module, for sleep-respiratory event whether to occur according to the data on flows and pressure data analysis user,
When sleep-respiratory event occurs for user, the class of the sleep-respiratory event is determined according to the data on flows and pressure data
Type；
The first adjustment module, for being adjusted according to scheduled adjustment mode corresponding with the type of the sleep-respiratory event
The parameter of the ventilator.
Preferably, the determining module includes:
Filter unit, it is bent for generating the corresponding flow curve of the data on flows and the corresponding pressure of the pressure data
Line is respectively filtered the flow curve and pressure curve；
First determination unit, in flow curve after the filtering, if the flow value is in the first preset time
0, it is determined that apnea occurs for user；
Second determination unit, if the amplitude for the flow value is reduced to the first default amplitude hereinafter, and the flow
The amplitude of value be reduced to the first default amplitude time below continue the second preset time, in second preset time at least
Have twice that breathing and the amplitude of the flow value are restored in third preset time to normal amplitude, it is determined that user's generation 1
Secondary low pass gas event；
Third determination unit, if the amplitude for the flow value is reduced to the first default amplitude or more and presets second
Below amplitude, it is determined that the relevant microarousal event of respiratory effort occurs for user, wherein the first default amplitude is less than described
Second default amplitude；
4th determination unit is greater than in pressure curve after the filtering, obtaining the pressure value in the 4th preset time
The set of the crest value of first preset pressure threshold value, and in the 4th preset time pressure value less than the second preset pressure threshold value
Valley value set, if the quantity of the element in the set of the crest value and the element in the set of the valley value is big
In preset quantity threshold value, alternatively, if the number of the element in the set of the crest value and the element in the set of the valley value
Amount, which is respectively less than, is equal to preset quantity threshold value, and each element in the set of the crest value is all larger than third preset pressure threshold value
Or each element in the set of the valley value is respectively less than the 4th preset pressure threshold value, it is determined that sound of snoring thing occurs for user
Part.
Preferably, first determination unit is specifically used for after calculating the kurtosis factor of filtered flow curve and filtering
Pressure curve the kurtosis factor；If the difference of the kurtosis factor of the kurtosis factor and pressure curve of flow curve is no more than default
Threshold value, then obstructive type apnea occurs for user, otherwise user's center of origin type apnea.
Preferably, the first adjustment module includes:
The first adjustment unit is used for when obstructive type apnea or maincenter type apnea occur for user,
Respiratory rate B and air-breathing expiratory duration ratio R when acquisition user's eupnea, exhale according to the respiratory rate B and air-breathing
Time ratios R calculates air-breathing expiratory duration ratio R ie, and the respiratory rate of ventilator is adjusted to breathing when user's eupnea
1.2 times of frequency provide machine control ventilation according to air-breathing expiratory duration ratio R ie, while adjusting ventilator in the following way
Pressure: it if obstructive type apnea at least twice occurs in the 5th preset time, is exhaled in a linear fashion by described
The pressure of inspiration(Pi) and breath pressure of suction machine increase at least 1cm H respectively2O；
Second adjustment unit is used in the 6th preset time, if at least 3 low pass gas events, Huo Zheyong occur for user
1 low pass gas event and 1 secondary stricture type apnea occur for family or the relevant micro- feel of 5 respiratory efforts occurs for user
Breath pressure is then increased at least 1cm H in a linear fashion in the 7th preset time by the event of waking up2O；
Third adjustment unit is used in the 8th preset time, if at least sound of snoring thing has occurred there are two the respiratory cycle in user
Breath pressure is then increased at least 1cm H in a linear fashion in the 9th preset time by part2O。
Preferably, the first adjustment unit is specifically used for according to the respiratory rate B and air-breathing expiratory duration ratio R meter
It calculates pressure of inspiration(Pi) and time Ti:Ti=(60/ (1+R))/1.2B is provided；Time Ti and respiratory rate are provided according to the pressure of inspiration(Pi)
B calculates breath pressure and provides time Te:Te=60/1.2B-Ti；Calculate the air-breathing expiratory duration ratio R ie=Ti/Te.
The beneficial effects of the present invention are: the present invention acquires the data on flows and pressure data of ventilator first, then basis
Whether data on flows and pressure data analysis user occur sleep-respiratory event, and when sleep-respiratory event occurs for user, really
The type that sleep-respiratory event occurs for user is determined, so that ventilator is according to the corresponding scheduled adjustment of type of sleep-respiratory event
Mode adjusts the parameter of ventilator, and since user is when occurring different sleep-respiratory events, flow and/or pressure have accordingly
Significant changes, therefore be monitored and analyze by flow to ventilator and pressure, can accurately detect user is currently
The no type that sleep-respiratory event and the sleep-respiratory event occurred occurs, and can be according to the type of sleep-respiratory event
Corresponding adjustment is made to the parameter of ventilator, is improved the user experience.
Detailed description of the invention
Fig. 1 is that the present invention is based on the flow diagrams of one embodiment of method of adjustment of the ventilator of breathing sleep event；
Fig. 2 is the flow diagram of step S2 shown in Fig. 1；
Fig. 3 is the pressue-graph respectively after passband filtering and low-pass filtering；
Fig. 4 is the corresponding flow-pressure diagram figure of obstructive type apnea；
Fig. 5 is the corresponding flow-pressure diagram figure of maincenter type apnea；
Fig. 6 is the structural schematic diagram of one embodiment of ventilator of the present invention；
Fig. 7 is the structural schematic diagram of determining module shown in Fig. 6.
Specific embodiment
The principle and features of the present invention will be described below with reference to the accompanying drawings, and the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the invention.
As shown in FIG. 1, FIG. 1 is the present invention is based on the processes of one embodiment of method of adjustment of the ventilator of breathing sleep event
Schematic diagram, should based on breathing sleep event ventilator method of adjustment the following steps are included:
Step S1 acquires the data on flows and pressure data of ventilator；
In the present embodiment, the data on flows and pressure data of sensor acquisition ventilator can be used, sensor includes stream
Quantity sensor and pressure sensor acquire data on flows and pressure data at ventilator gas outlet respectively, and user is in breathing
Different movements and state will produce different flow and pressure, so as to the data on flows acquired by analyte sensors
And pressure data detects the sleep-respiratory event whether user currently occurs.Wherein, flow sensor and pressure sensor
Sample frequency is 1000HZ.
Whether step S2 occurs sleep-respiratory event according to the data on flows and pressure data analysis user, in user
When sleep-respiratory event occurs, the type of the sleep-respiratory event is determined；
In the present embodiment, whether sleep-respiratory event can be occurred according to data on flows and pressure data analysis user, slept
Dormancy respiration case is according to type classification, including apnea, low pass gas event, the relevant microarousal event of respiratory effort
(resppiratory effort-related arousals, RERA) and sound of snoring event etc..If sleep-respiratory occurs for user
Event, then different states is presented in data on flows and pressure data respectively.
Wherein, some sleep-respiratory events only need to be analyzed according to data on flows, some are only needed according to number pressure
According to being analyzed, some needs are analyzed according to data on flows and pressure data.
In the analysis process, for example, when analyzing data on flows, the flow of user its value within the regular hour is 0, then
It can determine that apnea occurs for user；When analyzing pressure data, if there is biggish peak value in the pressure of ventilator
And this kind of situation maintains the regular hour, then can determine that sound of snoring event, etc. occurs for user.
The present embodiment can get flow sensor respectively by the central processing unit in ventilator and pressure sensor is adopted
The data on flows and pressure data of collection, then analyze data on flows and pressure data, to analyze whether user sleeps
Dormancy respiration case, and the type of the sleep-respiratory event is determined when sleep-respiratory event occurs for user.
Step S3 adjusts the ventilator according to scheduled adjustment mode corresponding with the type of the sleep-respiratory event
Parameter.
In the present embodiment, in ventilator, each sleep-respiratory event preset related response scheme or
The adjustment mode of person's ventilator can be according to the pre-set and sleep-respiratory thing when sleep-respiratory event occurs for user
The adjustment mode of the associated response scheme of part or ventilator is adjusted the parameter of ventilator, to assist using to the maximum extent
Family is breathed in generation sleep-respiratory event, and makes user's second wind state.Wherein, adjustable parameter includes working as
It is not limited to respiratory rate, air-breathing expiratory duration ratio, pressure of inspiration(Pi) and breath pressure.
For example, when user occur apnea when, pressure of inspiration(Pi) and respiratory rate can be increased, with assist user into
Row breathing, finally eliminates apnea；When sound of snoring event occurs for user, illustrate that the current air-breathing of user is more difficult, it can be with
Increase breath pressure, it is final to eliminate sound of snoring event to assist user to breathe.
After central processing unit of the present embodiment in ventilator determines the type for the sleep-respiratory event that user currently occurs,
The available parameter to scheduled adjustment mode adjustment ventilator, and the instruction for adjusting the parameter of ventilator is sent to and is exhaled
The motor of suction machine, motor are the critical components that ventilator generates Positive Airway Pressure, and motor generates gas-pressurized by running at high speed, i.e.,
Motor controls its revolving speed speed by central processing unit, so that the pressure at ventilator gas outlet is different.
Preferably, if sleep-respiratory event do not occur for user, and user do not occur sleep-respiratory event duration it is big
In the tenth preset time, then the pressure of the ventilator is lowered in a predetermined manner.
In the present embodiment, user needs to preset the interval range of a pressure change before using ventilator, for
Using the user of continuous positive airway pressure, usual initial pressure is set as 4cm H2O, maximum pressure are no more than 20cm H2O.For making
With the user of bi-level positive airway pressure, being normally set up initial expiratory pressure is 4cm H2O, maximum inspiratory pressure are 30cm H2O, most
Big pressure support ventilation (pressure of inspiration(Pi)-breath pressure) is 8cm H2O, minimum pressure support to be 4cm H2O。
Ventilator, can be according to upper when detecting user's generation sleep-respiratory event during providing pressure support ventilation
The method adjustment relevant parameter stated.Sleep-respiratory event does not occur when detecting user, and sleep-respiratory thing does not occur for user
The time of part continues 10 minutes or more, and ventilator will lower respectively pressure of inspiration(Pi) 0.5cm in 30S in a manner of linear function
H2O and downward breath pressure 0.5cm H2O, and keep again at least 10 minutes, it is slept if had in this 10 minutes kept
Dormancy respiration case occurs, and still can adjust relevant parameter according to above-mentioned method, and reopen timing in 10 minutes.If carry out
Sleep-respiratory event does not occur for user in this 10 minutes kept, then 10 minutes downward respiratory pressure 0.5cm H of every mistake2O。
Compared with prior art, the present embodiment acquires the data on flows and pressure data of ventilator first, then according to stream
Whether amount data and pressure data analysis user occur sleep-respiratory event, and when sleep-respiratory event occurs for user, determine
The type of sleep-respiratory event occurs for user, so that ventilator is according to the corresponding scheduled adjustment side of type of sleep-respiratory event
Formula adjusts the parameter of ventilator, and since user is when occurring different sleep-respiratory events, flow and/or pressure have accordingly
Significant changes, therefore be monitored and analyze by flow to ventilator and pressure, can accurately detect user currently whether
The type of sleep-respiratory event and the sleep-respiratory event occurred occurs, and can be according to the type pair of sleep-respiratory event
The parameter of ventilator makes corresponding adjustment, improves the user experience.
In a preferred embodiment, as shown in Fig. 2, on the basis of the embodiment of above-mentioned Fig. 1, above-mentioned steps S2 packet
It includes:
Step S21 generates the corresponding flow curve of the data on flows and the corresponding pressure curve of the pressure data, point
It is other that the flow curve and pressure curve are filtered；
Step S22, in flow curve after the filtering, if the flow value is 0 in the first preset time, it is determined that use
Apnea occurs for family；
Step S23, if the amplitude of the flow value be reduced to the first default amplitude hereinafter, and the flow value amplitude drop
Continue the second preset time down to the first default amplitude time below, at least breathed twice in second preset time
And the amplitude of the flow value is restored in third preset time to normal amplitude, it is determined that 1 low pass gas thing occurs for user
Part；
Step S24, if the amplitude of the flow value be reduced to the first default amplitude or more and in the second default amplitude hereinafter,
Then determine that the relevant microarousal event of respiratory effort occurs for user, wherein it is default that the first default amplitude is greater than described second
Amplitude；
Step S25 in pressure curve after the filtering, obtains the pressure value in the 4th preset time and is greater than the first default pressure
The set of the crest value of force threshold, and valley value of the pressure value less than the second preset pressure threshold value in the 4th preset time
Set, if the quantity of the element in the set of the crest value and the element in the set of the valley value is all larger than preset quantity
Threshold value, alternatively, if the quantity of the element in the set of the crest value and the element in the set of the valley value be respectively less than etc.
Each element in preset quantity threshold value, and in the set of the crest value is all larger than third preset pressure threshold value or the wave
Each element in the set of valley is respectively less than the 4th preset pressure threshold value, it is determined that sound of snoring event occurs for user.
In the present embodiment, the corresponding flow curve of data on flows and the corresponding pressure curve of pressure data are firstly generated, by
In the presence of noise and interference, flow curve and pressure curve are typically not ideal smooth state, and are filled with noise back
The waveform of scape, it is therefore desirable to it is filtered, then filtered data are analyzed, obtain the class of sleep-respiratory event
Type.
Preferably, two kinds of filters can be used, one is low-pass filters to obtain smooth for removing ambient noise
Curve, for determining that sleep-respiratory event is apnea, low pass gas event or RERA；Another kind is passband filtering
Device retains the vibration trend of curve, for determining sound of snoring event for removing part ambient noise.In building low-pass filter
When, it is preferable that it is 10HZ by frequency, and cutoff frequency is 60HZ, decays to 3db.The start-stop frequency of pass filter is distinguished
For 50HZ and 200HZ.
Specifically, bent for filtered flow when analyzing filtered flow curve and filtered pressure curve
Line, ventilator record the respiratory rate B of user, air-breathing expiratory duration ratio R in user's eupnea, when continuing first
(such as 6 seconds) flow value is that 0 (i.e. user breathes no more, in addition to fluctuating caused by the ambient noise in flow curve in preset time
Have almost no change), it is determined that apnea occurs for user；
If the amplitude of the flow value in filtered flow curve is reduced to the first default amplitude (such as to be reduced to basis
The 30% of amplitude) hereinafter, and the amplitude of flow value be reduced to for the first default amplitude time below continued the second preset time (example
Such as 10 seconds), in the second preset time at least twice the amplitude of breathing and flow value at (such as 1 point of third preset time
Clock) in restore to normal amplitude, it is determined that 1 low pass gas event occurs for user；
If the amplitude of the flow value in filtered flow curve is reduced to the first default amplitude (such as to be reduced to basis
The 30% of amplitude) more than and the second default amplitude (such as be reduced to underlying amplitude 10%) below, it is determined that user occur
The relevant microarousal event of respiratory effort, wherein the first default amplitude is less than the second default amplitude；Wherein, the stream breathed every time
The amplitude calculation method of magnitude are as follows: maximum value max and minimum value min are found out to filtered flow curve, obtaining amplitude is F=
max-min。
That is, leading to when determining user is that low pass gas event or the relevant microarousal event of respiratory effort occurs
It crosses filtered flow curve and can be seen that the flow curve amplitude breathed every time and gradually become smaller, go up later and gradually, and root
According to the degree difference to become smaller, determination is low pass gas event or the relevant microarousal event of respiratory effort.
In a preferred embodiment, determining that user is that low pass gas event or the relevant microarousal of respiratory effort occurs
When event, 3 minutes time slip-window can be constructed, when time window is empty, the breathing for assessing active user is
Whether no steady (i.e. eupnea), be no more than 10% when the flowrate amplitudes of continuous 3 breathings of user all differs, then it is assumed that currently
The breathing of user is in steady state, is suitable for building time window.At this point, this 3 times flow amplitude is all put into time window, make
For initial data, the flow amplitude of a breathing is often obtained later, is all compared with data existing in time window, if working as
The average value F of all flow amplitudes that preceding flow amplitude F0 is less than in time window is more than 10%, then not renewal time window, but
Carry out the judgement of low pass gas event or the relevant microarousal event of respiratory effort.If flow amplitude F0 is not less than average value F
90%, then renewal time window.When flow amplitude F0 is less than the 90% of average value F at least twice for appearance, it is necessary to really
It is fixed low pass gas event or the relevant microarousal event of respiratory effort whether occur, when flow amplitude F0 is less than average value F's
90% but do not reach 70% state and be continued above 10S, and have when breathing at least twice, it is relevant to be determined as respiratory effort
Microarousal event；When flow amplitude F0 is continued above 10S less than 70% state of average value F, and has and breathes at least twice,
It is determined as low pass gas event.Finally, if being restored to 90% or more of flow amplitude F0 in 1 minute internal respiration amplitude, it is determined that
Low pass gas event or the relevant microarousal event of respiratory effort occur for user, need to empty the data of time window at this time, again into
The building of row time window.If still not returning to 90% or more of F0 in 1 minute breathing amplitude, the time is directly emptied
Window is rebuild, while determining that low pass gas event or the relevant microarousal event of respiratory effort do not occur for user.
In pressure curve after the filtering, obtain default greater than first in the 4th preset time (such as 10 seconds) interior pressure value
Pressure threshold (such as 0.1cm H bigger than pressure mean values2O (centimeter water column)) crest value set, and it is default the 4th
Pressure value is less than the second preset pressure threshold value (such as 0.1cm H smaller than pressure mean values in time2O the set of valley value),
If the quantity of the element in the set of crest value and the element in the set of valley value is all larger than preset quantity threshold value (such as 5
It is a), alternatively, if the quantity of the element in the set of crest value and the element in the set of valley value, which is respectively less than, is equal to preset quantity
Threshold value (such as 5), and to be all larger than third preset pressure threshold value (such as average than pressure for each element in the set of crest value
It is worth big 0.2cm H2O each element) or in the set of the valley value be respectively less than the 4th preset pressure threshold value (such as than pressure
The small 0.2cm H of power average value2O), it is determined that sound of snoring event occurs for user.Wherein, third preset pressure threshold value pressure more default than first
Force threshold is big, and the 4th preset pressure threshold value is smaller than the second preset pressure threshold value.
Specifically, it can map and be further illustrated, as shown in figure 3, the filtered pressure curve note of pass filter
For L1, the filtered pressure curve of low-pass filter is denoted as L2, and pressure oscillation caused by ambient noise is usually in very little
Range, such as positive and negative 0.05cm H2O.If A=0.1cm H2O, then available two curves parallel with L1: L1+A, L1-A.
When sound of snoring event occurs for user, L2 inherently passes through L1+A and L1-A up and down.
In Fig. 3, the collection of crest value is combined into P2, P4, P6, P8, P10, P12, the collection of valley value be combined into P1, P3, P5, P7,
P9, P11, wherein the crest value between P5 and P6 is not more than L1+A, and valley value is not less than L1-A, therefore undesirable, together
Reason, the crest value and valley value between P9 and P10 are also undesirable.
Wherein, apnea includes that obstructive type apnea and maincenter type apnea, user are sending out
It is needed when both raw sleep-respiratory events using different measures.
In a preferred embodiment, obstructive type apnea and maincenter type apnea thing can be further discriminated between
Part, as shown in Figures 4 and 5, Fig. 4 are the corresponding flow-pressure diagram of obstructive type apnea, and Fig. 5 is the breathing of maincenter type
The corresponding flow-pressure diagram of suspending event.It can be seen from the figure that the corresponding flow rate pressure of obstructive type apnea
In curve, the form of the curve of flow and pressure is almost the same, and the corresponding flow-pressure diagram of maincenter type apnea
In, the form of the two has larger difference, and most important difference is that the convex portion of waveform.Therefore, the present embodiment selects
The kurtosis factor of curve is taken to describe different curves.Calculation method is: calculating separately the kurtosis of flow curve and pressure curve
Factor K f and Kp, calculation formula are as follows:Wherein yi indicates the value of i-th of sample, and Y indicates whole samples
Average value, N representative sample number, S indicate standard deviation.If the kurtosis factor of the kurtosis factor and pressure curve of flow curve
No more than preset threshold (i.e. Kf and Kp difference are no more than 0.5), then obstructive type apnea occurs difference for user, otherwise uses
Family center of origin type apnea.
In a preferred embodiment, above-mentioned steps S3 the following steps are included:
When obstructive type apnea or maincenter type apnea occur for user, when obtaining user's eupnea
Respiratory rate B and air-breathing expiratory duration ratio R, air-breathing is calculated according to the respiratory rate B and air-breathing expiratory duration ratio R and is exhaled
Gas time ratios Rie, 1.2 times of the respiratory rate when respiratory rate of ventilator to be adjusted to user's eupnea, according to suction
Gas expiratory duration ratio R ie provides machine control ventilation, while adjusting the pressure of ventilator in the following way: if when the 5th is default
Between obstructive type apnea at least twice occurs in (such as 5 minutes), then exhaled in a linear fashion by described in 15 seconds
The pressure of inspiration(Pi) and breath pressure of suction machine increase at least 1cm H respectively2O；Wherein, the breath pressure before ventilator adjustment is user
The exhaled airway positive pressure (Expiratory Positive Airway Pressure, EPAP) or lasting being being currently used
Positive pressure (Continuous Positive Airway Pressure, CPAP).
In the 6th preset time (such as 5 minutes), if at least 3 low pass gas events occur by user or user occurs 1
The relevant microarousal event of 5 respiratory efforts occurs for secondary low pass gas event and 1 secondary stricture type apnea or user,
Breath pressure is then increased at least 1cm H in a linear fashion in the 7th preset time (such as 15 seconds)2O；
In the 8th preset time (such as 3 minutes), if at least sound of snoring event has occurred there are two the respiratory cycle in user,
Breath pressure is increased at least 1cm H in a linear fashion in the 9th preset time (such as 15 seconds)2O。
Preferably, above-mentioned that air-breathing expiratory duration ratio is calculated according to the respiratory rate B and air-breathing expiratory duration ratio R
The step of Rie includes: to calculate pressure of inspiration(Pi) according to the respiratory rate B and air-breathing expiratory duration ratio R to provide time Ti:Ti=
(60/(1+R))/1.2B；Time Ti and respiratory rate B is provided according to the pressure of inspiration(Pi), and breath pressure offer time Te is provided:
Te=60/1.2B-Ti；Calculate the air-breathing expiratory duration ratio R ie=Ti/Te.
As shown in fig. 6, Fig. 6 be one embodiment of ventilator of the present invention structural schematic diagram, the ventilator include acquisition module,
Determining module and the first adjustment module, wherein acquisition module is integrated in the sensor of ventilator, and sensor includes flow sensing
Device and pressure sensor；Determining module and the first adjustment module are integrated in the central processing unit in ventilator.
Acquisition module 101, for acquiring the data on flows and pressure data of ventilator；
In the present embodiment, the data on flows and pressure data of sensor acquisition ventilator can be used, sensor includes stream
Quantity sensor and pressure sensor acquire data on flows and pressure data at ventilator gas outlet respectively, and user is in breathing
Different movements and state will produce different flow and pressure, so as to the data on flows acquired by analyte sensors
And pressure data detects the sleep-respiratory event whether user currently occurs.Wherein, flow sensor and pressure sensor
Sample frequency is 1000HZ.
Determining module 102, for sleep-respiratory thing whether to occur according to the data on flows and pressure data analysis user
Part determines the sleep-respiratory event according to the data on flows and pressure data when sleep-respiratory event occurs for user
Type；
In the present embodiment, whether sleep-respiratory event can be occurred according to data on flows and pressure data analysis user, slept
Dormancy respiration case is according to type classification, including apnea, low pass gas event, the relevant microarousal event of respiratory effort
(resppiratory effort-related arousals, RERA) and sound of snoring event etc..If sleep-respiratory occurs for user
Event, then different states is presented in data on flows and pressure data respectively.
Wherein, some sleep-respiratory events only need to be analyzed according to data on flows, some are only needed according to number pressure
According to being analyzed, some needs are analyzed according to data on flows and pressure data.
In the analysis process, for example, when analyzing data on flows, the flow of user its value within the regular hour is 0, then
It can determine that apnea occurs for user；When analyzing pressure data, if there is biggish peak value in the pressure of ventilator
And this kind of situation maintains the regular hour, then can determine that sound of snoring event, etc. occurs for user.
The present embodiment can get flow sensor respectively by the central processing unit in ventilator and pressure sensor is adopted
The data on flows and pressure data of collection, then analyze data on flows and pressure data, to analyze whether user sleeps
Dormancy respiration case, and the type of the sleep-respiratory event is determined when sleep-respiratory event occurs for user.
The first adjustment module 103, for according to scheduled adjustment mode corresponding with the type of the sleep-respiratory event
Adjust the parameter of the ventilator.
In the present embodiment, in ventilator, each sleep-respiratory event preset related response scheme or
The adjustment mode of person's ventilator can be according to the pre-set and sleep-respiratory thing when sleep-respiratory event occurs for user
The adjustment mode of the associated response scheme of part or ventilator is adjusted the parameter of ventilator, to assist using to the maximum extent
Family is breathed in generation sleep-respiratory event, and makes user's second wind state.Wherein, adjustable parameter includes working as
It is not limited to respiratory rate, air-breathing expiratory duration ratio, pressure of inspiration(Pi) and breath pressure.
For example, when user occur apnea when, pressure of inspiration(Pi) and respiratory rate can be increased, with assist user into
Row breathing, finally eliminates apnea；When sound of snoring event occurs for user, illustrate that the current air-breathing of user is more difficult, it can be with
Increase breath pressure, it is final to eliminate sound of snoring event to assist user to breathe.
After central processing unit of the present embodiment in ventilator determines the type for the sleep-respiratory event that user currently occurs,
The available parameter to scheduled adjustment mode adjustment ventilator, and the instruction for adjusting the parameter of ventilator is sent to and is exhaled
The motor of suction machine, motor are the critical components that ventilator generates Positive Airway Pressure, and motor generates gas-pressurized by running at high speed, i.e.,
Motor controls its revolving speed speed by central processing unit, so that the pressure at ventilator gas outlet is different.
Preferably, which further includes second adjustment module, if sleep-respiratory event does not occur for user, and user
The duration that sleep-respiratory event does not occur is greater than the tenth preset time, then lowers the ventilator in a predetermined manner
Pressure.
In the present embodiment, user needs to preset the interval range of a pressure change before using ventilator, for
Using the user of continuous positive airway pressure, usual initial pressure is set as 4cm H2O, maximum pressure are no more than 20cm H2O.For making
With the user of bi-level positive airway pressure, being normally set up initial expiratory pressure is 4cm H2O, maximum inspiratory pressure are 30cm H2O, most
Big pressure support ventilation (pressure of inspiration(Pi)-breath pressure) is 8cm H2O, minimum pressure support to be 4cm H2O。
Ventilator, can be according to upper when detecting user's generation sleep-respiratory event during providing pressure support ventilation
The method adjustment relevant parameter stated.Sleep-respiratory event does not occur when detecting user, and sleep-respiratory thing does not occur for user
The time of part continues 10 minutes or more, and ventilator will lower respectively pressure of inspiration(Pi) 0.5cm in 30S in a manner of linear function
H2O and downward breath pressure 0.5cm H2O, and keep again at least 10 minutes, it is slept if had in this 10 minutes kept
Dormancy respiration case occurs, and still can adjust relevant parameter according to above-mentioned method, and reopen timing in 10 minutes.If carry out
Sleep-respiratory event does not occur for user in this 10 minutes kept, then 10 minutes downward respiratory pressure 0.5cm H of every mistake2O。
In a preferred embodiment, as shown in fig. 7, on the basis of the embodiment of above-mentioned Fig. 6, above-mentioned determining module
102 include:
Filter unit 1021, for generating the corresponding flow curve of the data on flows and the corresponding pressure of the pressure data
Force curve is respectively filtered the flow curve and pressure curve；
First determination unit 1022, in flow curve after the filtering, if the flow in the first preset time
Value is 0, it is determined that apnea occurs for user；
Second determination unit 1023, if the amplitude for the flow value is reduced to the first default amplitude hereinafter, and described
The amplitude of flow value was reduced to for the first default amplitude time below continued the second preset time, in second preset time
At least the amplitude of breathing and the flow value is restored in third preset time to normal amplitude twice, it is determined that Yong Hufa
Raw 1 low pass gas event；
Third determination unit 1024, if the amplitude for the flow value is reduced to the first default amplitude or more and second
Below default amplitude, it is determined that the relevant microarousal event of respiratory effort occurs for user, wherein the first default amplitude is less than
The second default amplitude；
4th determination unit 1025, for obtaining the pressure value in the 4th preset time in pressure curve after the filtering
Greater than the set of the crest value of the first preset pressure threshold value, and in the 4th preset time pressure value less than the second preset pressure
The set of the valley value of threshold value, if the quantity of the element in the set of the crest value and the element in the set of the valley value
It is all larger than preset quantity threshold value, alternatively, if the element in the set of the crest value and the element in the set of the valley value
Quantity be respectively less than and be equal to preset quantity threshold value, and each element in the set of the crest value is all larger than third preset pressure
Each element in threshold value or the set of the valley value is respectively less than the 4th preset pressure threshold value, it is determined that the sound of snoring occurs for user
Event.
In the present embodiment, the corresponding flow curve of data on flows and the corresponding pressure curve of pressure data are firstly generated, by
In the presence of noise and interference, flow curve and pressure curve are typically not ideal smooth state, and are filled with noise back
The waveform of scape, it is therefore desirable to it is filtered, then filtered data are analyzed, obtain the class of sleep-respiratory event
Type.
Preferably, two kinds of filters can be used, one is low-pass filters to obtain smooth for removing ambient noise
Curve, for determining that sleep-respiratory event is apnea, low pass gas event or RERA；Another kind is passband filtering
Device retains the vibration trend of curve, for determining sound of snoring event for removing part ambient noise.In building low-pass filter
When, it is preferable that it is 10HZ by frequency, and cutoff frequency is 60HZ, decays to 3db.The start-stop frequency of pass filter is distinguished
For 50HZ and 200HZ.
Specifically, bent for filtered flow when analyzing filtered flow curve and filtered pressure curve
Line, ventilator record the respiratory rate B of user, air-breathing expiratory duration ratio R in user's eupnea, when continuing first
(such as 6 seconds) flow value is that 0 (i.e. user breathes no more, in addition to fluctuating caused by the ambient noise in flow curve in preset time
Have almost no change), it is determined that apnea occurs for user；
If the amplitude of the flow value in filtered flow curve is reduced to the first default amplitude (such as to be reduced to basis
The 30% of amplitude) hereinafter, and the amplitude of flow value be reduced to for the first default amplitude time below continued the second preset time (example
Such as 10 seconds), in the second preset time at least twice the amplitude of breathing and flow value at (such as 1 point of third preset time
Clock) in restore to normal amplitude, it is determined that 1 low pass gas event occurs for user；
If the amplitude of the flow value in filtered flow curve is reduced to the first default amplitude (such as to be reduced to basis
The 30% of amplitude) more than and the second default amplitude (such as be reduced to underlying amplitude 10%) below, it is determined that user occur
The relevant microarousal event of respiratory effort, wherein the first default amplitude is less than the second default amplitude；Wherein, the stream breathed every time
The amplitude calculation method of magnitude are as follows: maximum value max and minimum value min are found out to filtered flow curve, obtaining amplitude is F=
max-min。
That is, leading to when determining user is that low pass gas event or the relevant microarousal event of respiratory effort occurs
It crosses filtered flow curve and can be seen that the flow curve amplitude breathed every time and gradually become smaller, go up later and gradually, and root
According to the degree difference to become smaller, determination is low pass gas event or the relevant microarousal event of respiratory effort.
In a preferred embodiment, determining that user is that low pass gas event or the relevant microarousal of respiratory effort occurs
When event, 3 minutes time slip-window can be constructed, when time window is empty, the breathing for assessing active user is
Whether no steady (i.e. eupnea), be no more than 10% when the flowrate amplitudes of continuous 3 breathings of user all differs, then it is assumed that currently
The breathing of user is in steady state, is suitable for building time window.At this point, this 3 times flow amplitude is all put into time window, make
For initial data, the flow amplitude of a breathing is often obtained later, is all compared with data existing in time window, if working as
The average value F of all flow amplitudes that preceding flow amplitude F0 is less than in time window is more than 10%, then not renewal time window, but
Carry out the judgement of low pass gas event or the relevant microarousal event of respiratory effort.If flow amplitude F0 is not less than average value F
90%, then renewal time window.When flow amplitude F0 is less than the 90% of average value F at least twice for appearance, it is necessary to really
It is fixed low pass gas event or the relevant microarousal event of respiratory effort whether occur, when flow amplitude F0 is less than average value F's
90% but do not reach 70% state and be continued above 10S, and have when breathing at least twice, it is relevant to be determined as respiratory effort
Microarousal event；When flow amplitude F0 is continued above 10S less than 70% state of average value F, and has and breathes at least twice,
It is determined as low pass gas event.Finally, if being restored to 90% or more of flow amplitude F0 in 1 minute internal respiration amplitude, it is determined that
Low pass gas event or the relevant microarousal event of respiratory effort occur for user, need to empty the data of time window at this time, again into
The building of row time window.If still not returning to 90% or more of F0 in 1 minute breathing amplitude, the time is directly emptied
Window is rebuild, while determining that low pass gas event or the relevant microarousal event of respiratory effort do not occur for user.
In pressure curve after the filtering, obtain default greater than first in the 4th preset time (such as 10 seconds) interior pressure value
Pressure threshold (such as 0.1cm H bigger than pressure mean values2O the set of crest value), and the pressure in the 4th preset time
Value is less than the second preset pressure threshold value (such as 0.1cm H smaller than pressure mean values2O the set of valley value), if crest value
The quantity of element in set and the element in the set of valley value is all larger than preset quantity threshold value (such as 5), alternatively, if wave
The quantity of element in the set of peak value and the element in the set of valley value, which is respectively less than, is equal to preset quantity threshold value (such as 5
It is a), and to be all larger than third preset pressure threshold value (such as 0.2cm bigger than pressure mean values for each element in the set of crest value
H2O it is (such as smaller than pressure mean values that each element) or in the set of the valley value is respectively less than the 4th preset pressure threshold value
0.2cm H2O), it is determined that sound of snoring event occurs for user.Wherein, third preset pressure threshold value is bigger than the first preset pressure threshold value,
4th preset pressure threshold value is smaller than the second preset pressure threshold value.
Specifically, it can map and be further illustrated, as shown in figure 3, the filtered pressure curve note of pass filter
For L1, the filtered pressure curve of low-pass filter is denoted as L2, and pressure oscillation caused by ambient noise is usually in very little
Range, such as positive and negative 0.05cm H2O.If A=0.1cm H2O, then available two curves parallel with L1: L1+A, L1-A.
When sound of snoring event occurs for user, L2 inherently passes through L1+A and L1-A up and down.
In Fig. 3, the collection of crest value is combined into P2, P4, P6, P8, P10, P12, the collection of valley value be combined into P1, P3, P5, P7,
P9, P11, wherein the crest value between P5 and P6 is not more than L1+A, and valley value is not less than L1-A, therefore undesirable, together
Reason, the crest value and valley value between P9 and P10 are also undesirable.
Wherein, apnea includes that obstructive type apnea and maincenter type apnea, user are sending out
It is needed when both raw sleep-respiratory events using different measures.
In a preferred embodiment, obstructive type apnea and maincenter type apnea thing can be further discriminated between
Part, as shown in Figures 4 and 5, Fig. 4 are the corresponding flow-pressure diagram of obstructive type apnea, and Fig. 5 is the breathing of maincenter type
The corresponding flow-pressure diagram of suspending event.It can be seen from the figure that the corresponding flow rate pressure of obstructive type apnea
In curve, the form of the curve of flow and pressure is almost the same, and the corresponding flow-pressure diagram of maincenter type apnea
In, the form of the two has larger difference, and most important difference is that the convex portion of waveform.Therefore, the present embodiment selects
The kurtosis factor of curve is taken to describe different curves.First determination unit is specifically used for calculating separately flow curve and pressure is bent
Kurtosis the factor K f and Kp of line, calculation formula are as follows:Wherein yi indicates the value of i-th of sample, and Y is indicated
The average value of whole samples, N representative sample number, S indicate standard deviation.If the kurtosis factor of flow curve and the peak of pressure curve
The difference of the factor is spent no more than preset threshold (i.e. Kf and Kp difference are no more than 0.5), then obstructive type apnea thing occurs for user
Part, otherwise user's center of origin type apnea.
In a preferred embodiment, above-mentioned the first adjustment module 101 includes:
The first adjustment unit is used for when obstructive type apnea or maincenter type apnea occur for user,
Respiratory rate B and air-breathing expiratory duration ratio R when acquisition user's eupnea, exhale according to the respiratory rate B and air-breathing
Time ratios R calculates air-breathing expiratory duration ratio R ie, and the respiratory rate of ventilator is adjusted to breathing when user's eupnea
1.2 times of frequency provide machine control ventilation according to air-breathing expiratory duration ratio R ie, while adjusting ventilator in the following way
Pressure: if obstructive type apnea at least twice occurs in the 5th preset time (such as 5 minutes), in 15 seconds with
The pressure of inspiration(Pi) of the ventilator and breath pressure are increased at least 1cm H by linear mode respectively2O, wherein ventilator adjustment
Preceding breath pressure is exhaled airway positive pressure (the Expiratory Positive Airway that user is being currently used
Pressure, EPAP) or continuous positive pressure (Continuous Positive Airway Pressure, CPAP)；
Second adjustment unit, for interior in the 6th preset time (such as 5 minutes), if at least 3 low pass gas occur for user
Perhaps 1 low pass gas event and 1 secondary stricture type apnea occur event for user or 5 respiratory efforts occur for user
Relevant microarousal event then in a linear fashion increases breath pressure at least in the 7th preset time (such as 15 seconds)
1cm H2O；
Third adjustment unit, for interior in the 8th preset time (such as 3 minutes), if at least there are two the respiratory cycles by user
Sound of snoring event has occurred, then breath pressure is increased at least 1cm in a linear fashion in the 9th preset time (such as 15 seconds)
H2O。
Preferably, above-mentioned the first adjustment unit is specifically used for according to the respiratory rate B and air-breathing expiratory duration ratio R meter
It calculates pressure of inspiration(Pi) and time Ti:Ti=(60/ (1+R))/1.2B is provided；Time Ti and respiratory rate are provided according to the pressure of inspiration(Pi)
B calculates breath pressure and provides time Te:Te=60/1.2B-Ti；Calculate the air-breathing expiratory duration ratio R ie=Ti/Te.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of method of adjustment of the ventilator based on breathing sleep event, which is characterized in that described based on breathing sleep event
The method of adjustment of ventilator include:
S1 acquires the data on flows and pressure data of ventilator；
Whether S2 occurs sleep-respiratory event according to the data on flows and pressure data analysis user, sleeps in user
When respiration case, the type of the sleep-respiratory event is determined；
S3 adjusts the parameter of the ventilator according to scheduled adjustment mode corresponding with the type of the sleep-respiratory event；
The S2 includes:
S21 generates the corresponding flow curve of the data on flows and the corresponding pressure curve of the pressure data, respectively to described
Flow curve and pressure curve are filtered；
S22, in flow curve after the filtering, if the flow value is 0 in the first preset time, it is determined that user exhales
Inhale suspending event；
S23, if the amplitude of the flow value be reduced to the first default amplitude hereinafter, and the amplitude of the flow value be reduced to first
The default amplitude time below continues the second preset time, at least breathing twice and described in second preset time
The amplitude of flow value is restored in third preset time to normal amplitude, it is determined that 1 low pass gas event occurs for user；
S24, if the amplitude of the flow value is reduced to the first default amplitude or more and below the second default amplitude, it is determined that use
The relevant microarousal event of respiratory effort occurs for family, wherein the first default amplitude is less than the described second default amplitude；
S25 in pressure curve after the filtering, obtains the pressure value in the 4th preset time and is greater than the first preset pressure threshold value
The set of crest value, and in the 4th preset time pressure value less than the valley value of the second preset pressure threshold value set, if
The quantity of element in the set of the crest value and the element in the set of the valley value is all larger than preset quantity threshold value, or
Person, if the quantity of the element in the set of the crest value and the element in the set of the valley value, which is respectively less than, is equal to present count
Threshold value is measured, and each element in the set of the crest value is all larger than the collection of third preset pressure threshold value or the valley value
Each element in conjunction is respectively less than the 4th preset pressure threshold value, it is determined that sound of snoring event occurs for user.
2. the method for adjustment of the ventilator according to claim 1 based on breathing sleep event, which is characterized in that described
Judge that the step of apnea occurs for user further comprises in S22:
Calculate the kurtosis factor of filtered flow curve and the kurtosis factor of filtered pressure curve；
If the difference of the kurtosis factor of the kurtosis factor and pressure curve of flow curve is not more than preset threshold, user hinders
Plunger type apnea, otherwise user's center of origin type apnea.
3. the method for adjustment of the ventilator according to claim 2 based on breathing sleep event, which is characterized in that the S3
Include:
When obstructive type apnea or maincenter type apnea occur for user, exhaling when obtaining user's eupnea
Frequency B and air-breathing expiratory duration ratio R are inhaled, when calculating air-breathing expiration according to the respiratory rate B and air-breathing expiratory duration ratio R
Between ratio R ie, 1.2 times of the respiratory rate when respiratory rate of ventilator to be adjusted to user's eupnea, exhaled according to air-breathing
Gas time ratios Rie provides machine control ventilation, while adjusting the pressure of ventilator in the following way: if in the 5th preset time
Obstructive type apnea at least twice occurs, then in a linear fashion by the pressure of inspiration(Pi) and breath pressure of the ventilator
At least 1cm H is increased respectively2O；
In the 6th preset time, if at least 3 low pass gas events occur by user or 1 low pass gas event and 1 occurs for user
The relevant microarousal event of 5 respiratory efforts occurs for secondary stricture type apnea or user, then in the 7th preset time
Breath pressure is inside increased at least 1cm H in a linear fashion2O；
In the 8th preset time, if at least sound of snoring event has occurred there are two the respiratory cycle in user, in the 9th preset time
Breath pressure is inside increased at least 1cm H in a linear fashion2O。
4. the method for adjustment of the ventilator according to claim 3 based on breathing sleep event, which is characterized in that described
Include: according to the step of respiratory rate B and air-breathing expiratory duration ratio R calculating air-breathing expiratory duration ratio R ie
Pressure of inspiration(Pi) is calculated according to the respiratory rate B and air-breathing expiratory duration ratio R, and time Ti:Ti=(60/ (1+ is provided
R))/1.2B；
Time Ti and respiratory rate B is provided according to the pressure of inspiration(Pi), and breath pressure offer time Te:Te=60/1.2B- is provided
Ti；
Calculate the air-breathing expiratory duration ratio R ie=Ti/Te.
5. a kind of ventilator, which is characterized in that the ventilator includes:
Acquisition module, for acquiring the data on flows and pressure data of ventilator；
Determining module, for according to the data on flows and pressure data analysis user sleep-respiratory event whether occurs, with
When sleep-respiratory event occurs for family, the type of the sleep-respiratory event is determined according to the data on flows and pressure data；
The first adjustment module, for according to described in scheduled adjustment mode adjustment corresponding with the type of the sleep-respiratory event
The parameter of ventilator；
The determining module includes:
Filter unit, for generating the corresponding flow curve of the data on flows and the corresponding pressure curve of the pressure data,
The flow curve and pressure curve are filtered respectively；
First determination unit, in flow curve after the filtering, if the flow value is 0 in the first preset time,
Determine that apnea occurs for user；
Second determination unit, if the amplitude for the flow value is reduced to the first default amplitude hereinafter, and the flow value
Amplitude was reduced to for the first default amplitude time below continued the second preset time, at least two in second preset time
The amplitude of secondary breathing and the flow value is restored in third preset time to normal amplitude, it is determined that user's generation 1 time low
Ventilation event；
Third determination unit, if the amplitude for the flow value is reduced to the first default amplitude or more and in the second default amplitude
Below, it is determined that the relevant microarousal event of respiratory effort occurs for user, wherein the first default amplitude is less than described second
Default amplitude；
4th determination unit is greater than first in pressure curve after the filtering, obtaining the pressure value in the 4th preset time
The set of the crest value of preset pressure threshold value, and wave of the pressure value less than the second preset pressure threshold value in the 4th preset time
The set of valley, if the quantity of the element in the set of the crest value and the element in the set of the valley value be all larger than it is pre-
If amount threshold, alternatively, if the quantity of the element in the set of the crest value and the element in the set of the valley value is equal
Each element less than or equal to preset quantity threshold value, and in the set of the crest value be all larger than third preset pressure threshold value or
Each element in the set of the valley value is respectively less than the 4th preset pressure threshold value, it is determined that sound of snoring event occurs for user.
6. ventilator according to claim 5, which is characterized in that first determination unit is specifically used for after calculating filtering
Flow curve the kurtosis factor and filtered pressure curve the kurtosis factor；If the kurtosis factor of flow curve and pressure are bent
The difference of the kurtosis factor of line is not more than preset threshold, then obstructive type apnea occurs for user, otherwise in user's generation
Pivot type apnea.
7. ventilator according to claim 6, which is characterized in that the first adjustment module includes:
The first adjustment unit, for obtaining when obstructive type apnea or maincenter type apnea occur for user
Respiratory rate B and air-breathing expiratory duration ratio R when user's eupnea, according to the respiratory rate B and air-breathing expiratory duration
Ratio R calculates air-breathing expiratory duration ratio R ie, and the respiratory rate of ventilator is adjusted to respiratory rate when user's eupnea
1.2 times, according to air-breathing expiratory duration ratio R ie provide machine control ventilation, while in the following way adjust ventilator pressure:
If obstructive type apnea at least twice occurs in the 5th preset time, in a linear fashion by the ventilator
Pressure of inspiration(Pi) and breath pressure increase at least 1cm H respectively2O；
Second adjustment unit is used in the 6th preset time, if at least 3 low pass gas events or user's hair occur for user
The relevant microarousal thing of 5 respiratory efforts occurs for raw 1 low pass gas event and 1 secondary stricture type apnea or user
Breath pressure is then increased at least 1cm H in a linear fashion in the 7th preset time by part2O；
Third adjustment unit is used in the 8th preset time, if at least sound of snoring event has occurred there are two the respiratory cycle in user,
Breath pressure is increased at least 1cm H in a linear fashion in the 9th preset time2O。
8. ventilator according to claim 7, which is characterized in that the first adjustment unit is specifically used for exhaling according to
It inhales frequency B and air-breathing expiratory duration ratio R calculates pressure of inspiration(Pi) and provides time Ti:Ti=(60/ (1+R))/1.2B；According to described
Pressure of inspiration(Pi) provides time Ti and respiratory rate B and calculates breath pressure offer time Te:Te=60/1.2B-Ti；Calculate the suction
Gas expiratory duration ratio R ie=Ti/Te.
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| CN108619598B (en) * | 2017-03-17 | 2021-07-27 | 深圳市大雅医疗技术有限公司 | Pressure auto-titration system and method of breathing machine |
| CN109924980A (en) * | 2017-12-19 | 2019-06-25 | 北京怡和嘉业医疗科技股份有限公司 | Respiration case decision-making system and sleep monitor |
| CN109497949B (en) * | 2018-12-12 | 2022-04-22 | 深圳融昕医疗科技有限公司 | Method and device for detecting apnea type, breathing machine and storage medium |
| CN112245741A (en) * | 2020-11-06 | 2021-01-22 | 湖南万脉医疗科技有限公司 | Breathing machine adjusting method based on respiratory sleep event |
| CN113975563B (en) * | 2021-11-02 | 2024-06-21 | 成都泰盟软件有限公司 | Breathing machine control method based on snoring voice recognition and breathing machine |
| CN114209940B (en) * | 2021-12-30 | 2024-01-02 | 江苏鱼跃医疗设备股份有限公司 | Breathing phase control method of breathing machine based on dynamic threshold |
| CN117747117B (en) * | 2024-02-21 | 2024-05-24 | 安徽星辰智跃科技有限责任公司 | Sound-based sleep respiration evaluation and auxiliary adjustment method, system and device |
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