CN106474240A - The hormonal Traditional Chinese medicine health-preserving preparation of one kind conditioning human body - Google Patents
The hormonal Traditional Chinese medicine health-preserving preparation of one kind conditioning human body Download PDFInfo
- Publication number
- CN106474240A CN106474240A CN201610767305.4A CN201610767305A CN106474240A CN 106474240 A CN106474240 A CN 106474240A CN 201610767305 A CN201610767305 A CN 201610767305A CN 106474240 A CN106474240 A CN 106474240A
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- chinese medicine
- root
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 52
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 230000003054 hormonal effect Effects 0.000 title claims abstract description 11
- 230000003750 conditioning effect Effects 0.000 title abstract description 12
- 239000000284 extract Substances 0.000 claims abstract description 143
- 235000014676 Phragmites communis Nutrition 0.000 claims abstract description 20
- 244000124853 Perilla frutescens Species 0.000 claims abstract description 18
- 244000089698 Zanthoxylum simulans Species 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 18
- 241000207925 Leonurus Species 0.000 claims abstract description 15
- 235000004347 Perilla Nutrition 0.000 claims abstract description 15
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 15
- 235000021028 berry Nutrition 0.000 claims abstract description 15
- 235000005412 red sage Nutrition 0.000 claims abstract description 15
- 244000118350 Andrographis paniculata Species 0.000 claims abstract description 13
- 239000009429 Ginkgo biloba extract Substances 0.000 claims abstract description 12
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 12
- 235000020686 ginkgo biloba extract Nutrition 0.000 claims abstract description 12
- 229940068052 ginkgo biloba extract Drugs 0.000 claims abstract description 12
- 229940064221 ligusticum wallichii root extract Drugs 0.000 claims abstract description 12
- 239000009806 pulsatillae Substances 0.000 claims abstract description 12
- 241000594394 Hedyotis Species 0.000 claims abstract description 10
- 244000081757 Phalaris arundinacea Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 28
- 239000003921 oil Substances 0.000 claims description 22
- -1 jojoba oil Substances 0.000 claims description 21
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 20
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 15
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 15
- 235000013399 edible fruits Nutrition 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 14
- 229940119170 jojoba wax Drugs 0.000 claims description 14
- 239000011732 tocopherol Substances 0.000 claims description 14
- 229930003799 tocopherol Natural products 0.000 claims description 14
- 229960001295 tocopherol Drugs 0.000 claims description 14
- 235000010384 tocopherol Nutrition 0.000 claims description 14
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 14
- 239000010685 fatty oil Substances 0.000 claims description 13
- 229930182478 glucoside Natural products 0.000 claims description 13
- 238000010792 warming Methods 0.000 claims description 13
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 11
- 241000736199 Paeonia Species 0.000 claims description 11
- 235000005152 nicotinamide Nutrition 0.000 claims description 11
- 229960003966 nicotinamide Drugs 0.000 claims description 11
- 239000011570 nicotinamide Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- 238000003786 synthesis reaction Methods 0.000 claims description 8
- 244000025254 Cannabis sativa Species 0.000 claims description 5
- 239000012467 final product Substances 0.000 claims description 5
- 241000157511 Oldenlandia Species 0.000 claims description 2
- 229940060184 oil ingredients Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 abstract description 12
- 229940088597 hormone Drugs 0.000 abstract description 12
- 238000000554 physical therapy Methods 0.000 abstract description 3
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 244000194101 Ginkgo biloba Species 0.000 description 6
- 235000008100 Ginkgo biloba Nutrition 0.000 description 6
- 240000001659 Oldenlandia diffusa Species 0.000 description 6
- 240000005001 Paeonia suffruticosa Species 0.000 description 6
- 235000003889 Paeonia suffruticosa Nutrition 0.000 description 6
- 240000007436 Cananga odorata Species 0.000 description 4
- 235000007571 Cananga odorata Nutrition 0.000 description 4
- 206010016256 fatigue Diseases 0.000 description 4
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 3
- 235000011201 Ginkgo Nutrition 0.000 description 3
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 description 3
- 240000002817 Leonurus sibiricus Species 0.000 description 3
- 235000002434 Leonurus sibiricus Nutrition 0.000 description 3
- 241000244365 Ligusticum sinense Species 0.000 description 3
- 241000112528 Ligusticum striatum Species 0.000 description 3
- 235000004348 Perilla frutescens Nutrition 0.000 description 3
- 241000123887 Pulsatilla chinensis Species 0.000 description 3
- 241001504477 Pycnonotidae Species 0.000 description 3
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 3
- 241000244317 Tillandsia usneoides Species 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000019504 cigarettes Nutrition 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- 244000132619 red sage Species 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- 229940046009 vitamin E Drugs 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 240000000902 Diospyros discolor Species 0.000 description 2
- 235000003115 Diospyros discolor Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000003890 endocrine cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000003688 hormone derivative Substances 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000003075 phytoestrogen Substances 0.000 description 1
- 239000002281 placental hormone Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/10—Bryophyta (mosses)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to technical field of Chinese medicine, specifically discloses a kind of hormonal Traditional Chinese medicine health-preserving preparation of conditioning human body.Described Traditional Chinese medicine health-preserving preparation includes the following raw material composition：Red sage root root extract, Yilan flower extract, peony root extractive, Andrographis Paniculata, herba hedyotis diffusae extract, perilla leaf extract, spire Leonurus extract, Ligusticum wallichii root extract, ginkgo biloba extract, reed reed grass extract, Chinese prickly ash berry extract, Radix Pulsatillae extract, Spain's moss tongue extract.Described Traditional Chinese medicine health-preserving preparation combines the Chinese physical therapy massage manipulation of specialty, can nurse one's health human body hormone, so as to reach the purpose for improving human-body sub-health.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to the hormonal Traditional Chinese medicine health-preserving preparation of one kind conditioning human body.
Background technology
Also known as hormone, hormone is the synthesis of well differentiated endocrine cell the chemical information for being directly secreted into blood to hormone
Material, it affect the physiological activity of human body by adjusting various histiocytic metabolic activities.By incretory or endocrine
The efficient bio-active material of cell secretion, in vivo as courier's transmission information, to body
The material that physiology course is played regulatory role is referred to as hormone.It is the important substance in our life.
Hormone conditioning agent on existing market mainly has：Synthetic hormones, animality placental hormone, vegetalitas tire
Disk element, isoflavones, queen bee breast etc..But there are the following problems for existing hormone conditioning agent：1st, can only supplement single
Hormone, unnecessary hoard in vivo, cause atrophy, the abnormal hyperplasia of cell increases carcinogenic probability.2, animality is originated not
Bright, cause arm to fester allergy sometimes.3, plant placeula element originally acts on small in human body.4, the single hormone of supplement, easily
Tumor proliferative is stimulated to grow up.
Content of the invention
The technical problem to be solved is, for the problems referred to above for overcoming prior art to exist, to provide a kind of tune
The hormonal Traditional Chinese medicine health-preserving preparation of reason human body.
Above-mentioned technical problem to be solved by this invention, is achieved by the following technical programs：
The hormonal Traditional Chinese medicine health-preserving preparation of one kind conditioning human body, comprising the following raw material composition：Red sage root root extract, Cananga odorata are extracted
Thing, peony root extractive, Andrographis Paniculata, herba hedyotis diffusae extract, perilla leaf extract, spire Leonurus extract,
Ligusticum wallichii root extract, ginkgo biloba extract, reed reed grass extract, Chinese prickly ash berry extract, Radix Pulsatillae extract, Spain moss tongue are extracted
Thing.
Preferably, described Traditional Chinese medicine health-preserving preparation, also includes the following raw material composition：Butyrospermum parkii fruit fatty oil, jojoba oil,
Tocopherol, iso stearyl glucoside, glycerine, niacinamide, water.
Preferably, described Traditional Chinese medicine health-preserving preparation, the material composition comprising following weight portion：
5 ~ 10 parts of red sage root root extract, 1 ~ 3 part of Yilan flower extract, 3 ~ 5 parts of peony root extractive, 1 ~ 3 part of Andrographis Paniculata,
5 ~ 10 parts of herba hedyotis diffusae extract, 1 ~ 3 part of perilla leaf extract, 5 ~ 10 parts of spire Leonurus extract, Ligusticum wallichii root extract 5
~ 10 parts, 5 ~ 10 parts of ginkgo biloba extract, reed reed grass 5 ~ 10 parts of extract, 0.5 ~ 1 part of Chinese prickly ash berry extract, Radix Pulsatillae extract 0.5
~ 1 part, 0.5 ~ 1 part of Spain moss tongue extract.
Most preferably, described Traditional Chinese medicine health-preserving preparation, the material composition comprising following weight portion：
5 parts of red sage root root extract, 2 parts of Yilan flower extract, 3 parts of peony root extractive, 2 parts of Andrographis Paniculata, oldenlandia
5 parts of careless extract, 2 parts of perilla leaf extract, 5 parts of spire Leonurus extract, 5 parts of Ligusticum wallichii root extract, ginkgo biloba extract 5
Part, reed reed 5 parts of extract of grass, 0.5 part of Chinese prickly ash berry extract, 0.5 part of Radix Pulsatillae extract, 0.5 part of Spain moss tongue extract.
Preferably, described Traditional Chinese medicine health-preserving preparation, the also material composition comprising following weight portion：Butyrospermum parkii fruit fatty oil 1 ~
3 parts, 3 ~ 5 parts of jojoba oil, 0.5 ~ 2 part of tocopherol, 3 ~ 5 parts of iso stearyl glucoside, 5 ~ 10 parts of glycerine, 0.5 ~ 2 part of niacinamide,
30 ~ 50 parts of water.
Most preferably, described Traditional Chinese medicine health-preserving preparation, the also material composition comprising following weight portion：Butyrospermum parkii fruit fatty oil
2 parts, 3 parts of jojoba oil, 1 part of tocopherol, 3 parts of iso stearyl glucoside, 5 parts of glycerine, 1 part of niacinamide, 30 parts of water.
The preparation method of above-mentioned Traditional Chinese medicine health-preserving preparation, comprises the steps of：
（1）By oil phase, water mutually by formula precise, and mix；
（2）Oil phase is warming up to 70 ~ 80 DEG C, water is mutually warming up to 80 ~ 90 DEG C, and each self-heat conserving 20 ~ 40 minutes；
（3）Under the conditions of -0.05 ~ -0.2MPa, oil water phase is slowly mixed together, and ceaselessly stirring homogeneous；
（4）Temperature adds red sage root root extract, Yilan flower extract, peony root extractive, Herba Andrographitis to extract when being down to 25 ~ 35 DEG C
Thing, herba hedyotis diffusae extract, perilla leaf extract, spire Leonurus extract, Ligusticum wallichii root extract, ginkgo biloba extract, reed
Reed grass extract, Chinese prickly ash berry extract, Radix Pulsatillae extract and Spain's moss tongue extract, stir and obtain final product described Chinese medicine
Health preparation.
Preferably, step（1）Described oil phase is Butyrospermum parkii fruit fatty oil, jojoba oil, tocopherol, iso stearyl glucose
Glycosides；Described water is mutually glycerine, niacinamide, water.
Preferably, step（2）Middle oil phase is warming up to 75 DEG C, water is mutually warming up to 85 DEG C, and each self-heat conserving 30 minutes.
Preferably, step（3）In under the conditions of -0.1MPa, oil water phase is slowly mixed together；Step（4）Middle temperature is down to 30
DEG C when add extract.
Beneficial effect：（1）The invention provides a kind of hormonal Traditional Chinese medicine health-preserving preparation of brand-new conditioning human body, described
Traditional Chinese medicine health-preserving pharmaceutical formulation is the traditional theory according to the traditional Chinese medical science, gets in conjunction with substantial amounts of experiment sieving, will be of the present invention
Traditional Chinese medicine health-preserving preparation combine specialty Chinese physical therapy massage manipulation, human body hormone can be nursed one's health, so as to reach improvement
The purpose of human-body sub-health；（2）Described Traditional Chinese medicine health-preserving preparation is pure natural components, without animality and phytoestrogens, makes
Used time is combined by Chinese medicine conditioning and physiotherapy, safe and reliable；（3）Traditional Chinese medicine health-preserving preparation of the present invention does not rely on supplement
Single hormone product, will not stimulate human body to produce tumour cell and affected organ；（4）Traditional Chinese medicine health-preserving system of the present invention
Agent is to reach effect persistently by improving physique, the effect not rebounded, and regardless of sex when described Chinese medicine preparation is used, and fits
Wide with age bracket.
Specific embodiment
The present invention is explained further below in conjunction with specific embodiment, but embodiment does not do any type of limit to the present invention
Fixed.
Unreceipted actual conditions person in embodiment, the condition that advises according to normal condition or manufacturer are carried out.Wherein, used
Reagent or the unreceipted production firm person of instrument, be can by city available from conventional products.
Embodiment 1 nurses one's health the preparation of the hormonal Traditional Chinese medicine health-preserving preparation of human body
Formula：The red sage root（SALVIA MILTIORRHIZA）5 parts of root extract, Yilan（CANANGA ODORATA）Flower extract 2
Part, tree peony（PAEONIA SUFFRUTICOSA）3 parts of root extract, Herba Andrographitis（ANDROGRAPHIS PANICULATA）Extract
2 parts of thing, oldenlandia diffusa（HEDYOTIS DIFFUSA）5 parts of extract, purple perilla（PERILLA OCYMOIDES）Leaf extract 2
Part, spire motherwort（LEONURUS SIBIRICUS）5 parts of extract, Ligusticum wallichii（LIGUSTICUM CHUANXIONG）Root is extracted
5 parts of thing, ginkgo（GINKGO BILOBA）5 parts of extract, Mexico's reed reed 5 parts of extract of grass, Chinese prickly ash（ZANTHOXYLUM
BUNGEANUM）0.5 part of berry extract, the Chinese bulbul（PULSATILLA CHINENSIS）0.5 part of extract, Spain moss tongue
（TILLANDSIA USNEOIDES）0.5 part of extract, tocopherol（Vitamin E）1 part, 5 parts of glycerine, 1 part of niacinamide, butter fruit
Tree（BUTYROSPERMUM PARKII）2 parts of fruit fatty oil, 3 parts of jojoba oil of synthesis, 3 parts of iso stearyl glucoside, 30 parts of water；
Preparation method：
（1）By oil phase（Butyrospermum parkii fruit fatty oil, synthesis jojoba oil, tocopherol, iso stearyl glucoside）, water phase（Glycerine, cigarette
Acid amides, water）By formula precise, and mix；
（2）Oil phase is warming up to 75, water is mutually warming up to 85, and each self-heat conserving 3 minutes；
（3）Under the conditions of -0.1Pa, oil water phase is slowly mixed together, and ceaselessly stirring homogeneous；
（4）Add when temperature is down to 30 DEG C red sage root root extract, Yilan flower extract, peony root extractive, Andrographis Paniculata,
Herba hedyotis diffusae extract, perilla leaf extract, spire Leonurus extract, Ligusticum wallichii root extract, ginkgo biloba extract, reed reed grass
Extract, Chinese prickly ash berry extract, Radix Pulsatillae extract and Spain's moss tongue extract, stir and obtain final product described Traditional Chinese medicine health-preserving
Preparation.
The preparation of 2 Traditional Chinese medicine health-preserving preparation of embodiment
Formula：The red sage root（SALVIA MILTIORRHIZA）10 parts of root extract, Yilan（CANANGA ODORATA）Flower extract 1
Part, tree peony（PAEONIA SUFFRUTICOSA）3 parts of root extract, Herba Andrographitis（ANDROGRAPHIS PANICULATA）Extract
1 part of thing, oldenlandia diffusa（HEDYOTIS DIFFUSA）10 parts of extract, purple perilla（PERILLA OCYMOIDES）Leaf extract 1
Part, spire motherwort（LEONURUS SIBIRICUS）10 parts of extract, Ligusticum wallichii（LIGUSTICUM CHUANXIONG）Root is extracted
10 parts of thing, ginkgo（GINKGO BILOBA）10 parts of extract, Mexico's reed reed 10 parts of extract of grass, Chinese prickly ash（ZANTHOXYLUM
BUNGEANUM）1 part of berry extract, the Chinese bulbul（PULSATILLA CHINENSIS）1 part of extract, Spain moss tongue
（TILLANDSIA USNEOIDES）1 part of extract, tocopherol（Vitamin E）1 part, 5 parts of glycerine, 1 part of niacinamide, Butyrospermum parkii
（BUTYROSPERMUM PARKII）1 part of fruit fatty oil, 3 parts of jojoba oil of synthesis, 3 parts of iso stearyl glucoside, 50 parts of water；
Preparation method：
（1）By oil phase（Butyrospermum parkii fruit fatty oil, synthesis jojoba oil, tocopherol, iso stearyl glucoside）, water phase（Glycerine, cigarette
Acid amides, water）By formula precise, and mix；
（2）Oil phase is warming up to 75, water is mutually warming up to 85, and each self-heat conserving 3 minutes；
（3）Under the conditions of -0.1Pa, oil water phase is slowly mixed together, and ceaselessly stirring homogeneous；
（4）Add when temperature is down to 30 DEG C red sage root root extract, Yilan flower extract, peony root extractive, Andrographis Paniculata,
Herba hedyotis diffusae extract, perilla leaf extract, spire Leonurus extract, Ligusticum wallichii root extract, ginkgo biloba extract, reed reed grass
Extract, Chinese prickly ash berry extract, Radix Pulsatillae extract and Spain's moss tongue extract, stir and obtain final product described Traditional Chinese medicine health-preserving
Preparation.
The preparation of 3 Traditional Chinese medicine health-preserving preparation of embodiment
Formula：The red sage root（SALVIA MILTIORRHIZA）5 parts of root extract, Yilan（CANANGA ODORATA）Flower extract 3
Part, tree peony（PAEONIA SUFFRUTICOSA）3 parts of root extract, Herba Andrographitis（ANDROGRAPHIS PANICULATA）Extract
3 parts of thing, oldenlandia diffusa（HEDYOTIS DIFFUSA）5 parts of extract, purple perilla（PERILLA OCYMOIDES）Leaf extract 3
Part, spire motherwort（LEONURUS SIBIRICUS）5 parts of extract, Ligusticum wallichii（LIGUSTICUM CHUANXIONG）Root is extracted
5 parts of thing, ginkgo（GINKGO BILOBA）5 parts of extract, Mexico's reed reed 5 parts of extract of grass, Chinese prickly ash（ZANTHOXYLUM
BUNGEANUM）1 part of berry extract, the Chinese bulbul（PULSATILLA CHINENSIS）0.5 part of extract, Spain moss tongue
（TILLANDSIA USNEOIDES）1 part of extract, tocopherol（Vitamin E）2 parts, 10 parts of glycerine, 2 parts of niacinamide, butter fruit
Tree（BUTYROSPERMUM PARKII）3 parts of fruit fatty oil, 5 parts of jojoba oil of synthesis, 3 parts of iso stearyl glucoside, 30 parts of water；
Preparation method：
（1）By oil phase（Butyrospermum parkii fruit fatty oil, synthesis jojoba oil, tocopherol, iso stearyl glucoside）, water phase（Glycerine, cigarette
Acid amides, water）By formula precise, and mix；
（2）Oil phase is warming up to 75, water is mutually warming up to 85, and each self-heat conserving 3 minutes；
（3）Under the conditions of -0.1Pa, oil water phase is slowly mixed together, and ceaselessly stirring homogeneous；
（4）Add when temperature is down to 30 DEG C red sage root root extract, Yilan flower extract, peony root extractive, Andrographis Paniculata,
Herba hedyotis diffusae extract, perilla leaf extract, spire Leonurus extract, Ligusticum wallichii root extract, ginkgo biloba extract, reed reed grass
Extract, Chinese prickly ash berry extract, Radix Pulsatillae extract and Spain's moss tongue extract, stir and obtain final product described Traditional Chinese medicine health-preserving
Preparation.
The hormonal Traditional Chinese medicine health-preserving preparation effect test of the conditioning human body of the present invention of embodiment 4
Experimental subjects：Choose 150 life stress big, fatiguability, the volunteer of 30 ~ 40 years old in sub-health state.It is divided into
Tri- groups of A, B, C, per group 50；The Traditional Chinese medicine health-preserving preparation that A group is prepared using the embodiment of the present invention 1, B group use common tool
There is the essential oil for alleviating inferior health function；C group does not carry out any process.
Using method is：Back, shoulder neck massage are carried out using Traditional Chinese medicine health-preserving preparation, massaged once per 2 days, after two weeks
Test effect.
Additionally, stop 1 month test effect again after massage, to verify the persistence of Traditional Chinese medicine health-preserving preparation effect.Knot
Fruit is shown in Table 1.
Effectively：Hale and hearty, fatigue symptom is substantially eased；
Effective：The state of mind makes moderate progress, and fatigue symptom has been alleviated；
Invalid：Spirit, fatigue symptom do not improve and alleviate.
Can be seen that using the hormonal Traditional Chinese medicine health-preserving of conditioning human body described in the embodiment of the present invention 1 from 1 test effect data of table
Preparation carries out massage conditioning, and which is efficient to reach 90%, and inefficiency is 0%, illustrates which can significantly improve human-body sub-health
State, significantly larger than B group are using the effect of common essential oil.Additionally, stopping using 1, Traditional Chinese medicine health-preserving preparation of the present invention
After month, efficient is still 90%, and the efficient of B group drops to 20%, and this explanation Traditional Chinese medicine health-preserving preparation of the present invention improves
Effectively, reason is which can fundamentally nurse one's health human body hormone to the persistent of inferior health, improves physique, holds so as to reach effect
Long, the purpose not rebounded.
Claims (10)
1. one kind nurses one's health the hormonal Traditional Chinese medicine health-preserving preparation of human body, it is characterised in that comprising the following raw material composition：Red sage root is extracted
Thing, Yilan flower extract, peony root extractive, Andrographis Paniculata, herba hedyotis diffusae extract, perilla leaf extract, spire
Leonurus extract, Ligusticum wallichii root extract, ginkgo biloba extract, reed reed grass extract, Chinese prickly ash berry extract, Radix Pulsatillae extract,
Spain's moss tongue extract.
2. Traditional Chinese medicine health-preserving preparation according to claim 1, it is characterised in that also include the following raw material composition：Butyrospermum parkii
Fruit fatty oil, jojoba oil, tocopherol, iso stearyl glucoside, glycerine, niacinamide, water.
3. Traditional Chinese medicine health-preserving preparation according to claim 1, it is characterised in that the material composition comprising following weight portion：
5 ~ 10 parts of red sage root root extract, 1 ~ 3 part of Yilan flower extract, 3 ~ 5 parts of peony root extractive, 1 ~ 3 part of Andrographis Paniculata,
5 ~ 10 parts of herba hedyotis diffusae extract, 1 ~ 3 part of perilla leaf extract, 5 ~ 10 parts of spire Leonurus extract, Ligusticum wallichii root extract 5
~ 10 parts, 5 ~ 10 parts of ginkgo biloba extract, reed reed grass 5 ~ 10 parts of extract, 0.5 ~ 1 part of Chinese prickly ash berry extract, Radix Pulsatillae extract 0.5
~ 1 part, 0.5 ~ 1 part of Spain moss tongue extract.
4. Traditional Chinese medicine health-preserving preparation according to claim 3, it is characterised in that the material composition comprising following weight portion：
5 parts of red sage root root extract, 2 parts of Yilan flower extract, 3 parts of peony root extractive, 2 parts of Andrographis Paniculata, oldenlandia
5 parts of careless extract, 2 parts of perilla leaf extract, 5 parts of spire Leonurus extract, 5 parts of Ligusticum wallichii root extract, ginkgo biloba extract 5
Part, reed reed 5 parts of extract of grass, 0.5 part of Chinese prickly ash berry extract, 0.5 part of Radix Pulsatillae extract, 0.5 part of Spain moss tongue extract.
5. Traditional Chinese medicine health-preserving preparation according to claim 2, it is characterised in that the also material composition comprising following weight portion：
1 ~ 3 part of Butyrospermum parkii fruit fatty oil, 3 ~ 5 parts of jojoba oil of synthesis, 0.5 ~ 2 part of tocopherol, 3 ~ 5 parts of iso stearyl glucoside, glycerine 5
~ 10 parts, 0.5 ~ 2 part of niacinamide, 30 ~ 50 parts of water.
6. Traditional Chinese medicine health-preserving preparation according to claim 5, it is characterised in that the also material composition comprising following weight portion：
2 parts of Butyrospermum parkii fruit fatty oil, 3 parts of jojoba oil, 1 part of tocopherol, 3 parts of iso stearyl glucoside, 5 parts of glycerine, 1 part of niacinamide,
30 parts of water.
7. the preparation method of the Traditional Chinese medicine health-preserving preparation described in any one of claim 1 ~ 6, it is characterised in that comprise the steps of：
（1）By oil phase, water mutually by formula precise, and mix；
（2）Oil phase is warming up to 70 ~ 80 DEG C, water is mutually warming up to 80 ~ 90 DEG C, and each self-heat conserving 20 ~ 40 minutes；
（3）Under the conditions of -0.05 ~ -0.2MPa, oil water phase is slowly mixed together, and ceaselessly stirring homogeneous；
（4）Temperature adds red sage root root extract, Yilan flower extract, peony root extractive, Herba Andrographitis to extract when being down to 25 ~ 35 DEG C
Thing, herba hedyotis diffusae extract, perilla leaf extract, spire Leonurus extract, Ligusticum wallichii root extract, ginkgo biloba extract, reed
Reed grass extract, Chinese prickly ash berry extract, Radix Pulsatillae extract and Spain's moss tongue extract, stir and obtain final product described Chinese medicine
Health preparation.
8. preparation method according to claim 7, it is characterised in that step（1）Described oil phase is Butyrospermum parkii fruit fat
Oil, jojoba oil, tocopherol, iso stearyl glucoside；Described water is mutually glycerine, niacinamide, water.
9. preparation method according to claim 7, it is characterised in that step（2）Middle oil phase is warming up to 75 DEG C, water phase liter
Temperature is to 85 DEG C, and each self-heat conserving 30 minutes.
10. preparation method according to claim 7, it is characterised in that step（3）In under the conditions of -0.1MPa, oil phase water
Mutually it is slowly mixed together；Step（4）Middle temperature adds extract when being down to 30 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610767305.4A CN106474240A (en) | 2016-08-31 | 2016-08-31 | The hormonal Traditional Chinese medicine health-preserving preparation of one kind conditioning human body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610767305.4A CN106474240A (en) | 2016-08-31 | 2016-08-31 | The hormonal Traditional Chinese medicine health-preserving preparation of one kind conditioning human body |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106474240A true CN106474240A (en) | 2017-03-08 |
Family
ID=58273958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610767305.4A Pending CN106474240A (en) | 2016-08-31 | 2016-08-31 | The hormonal Traditional Chinese medicine health-preserving preparation of one kind conditioning human body |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106474240A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1394593A (en) * | 2002-05-15 | 2003-02-05 | 孙和平 | Equilibrium cream and its preparation method |
| CN102085172A (en) * | 2011-01-25 | 2011-06-08 | 深圳市金因生物技术有限公司 | Skin care cosmetic taking American wild yam extract as main component and preparation method thereof |
-
2016
- 2016-08-31 CN CN201610767305.4A patent/CN106474240A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1394593A (en) * | 2002-05-15 | 2003-02-05 | 孙和平 | Equilibrium cream and its preparation method |
| CN102085172A (en) * | 2011-01-25 | 2011-06-08 | 深圳市金因生物技术有限公司 | Skin care cosmetic taking American wild yam extract as main component and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 李铭磊: "华调保湿乳液", 《HTTPS://WWW.DOUBAN.COM/GROUP/TOPIC/67569787/》 * |
| 百度百科: "异硬脂基葡糖苷", 《HTTPS://BAIKE.BAIDU.COM/ITEM/异硬脂基葡糖苷?SEFR=ENTERBTN》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104856009A (en) | An eucommia ulmoides staminate flower health-care product | |
| US9554985B2 (en) | Agent for promoting hair growth and method for preparing same | |
| CN104586669A (en) | Fat-reducing externally-applied cream | |
| CN104824254A (en) | Healthcare tea and making method thereof | |
| CN101011483B (en) | Chinese medicinal formulation for treating children's digestive system disease and its preparation method | |
| CN104825914A (en) | Traditional Chinese medicinal preparation for assisted treatment of breast cancer | |
| CN105055849B (en) | Enriching yin Chinese medical extract for nourishing kidney and its preparation method and application | |
| CN103540496B (en) | Traditional Chinese medicine life-cultivating and health-preserving wine and preparation method thereof | |
| CN101926857B (en) | Traditional Chinese medicinal liniment for treating vitiligo | |
| CN104225090B (en) | A kind of preparation for increasing milk production of cow and preparation method thereof | |
| CN103053767A (en) | Method for preparing desert cistanche health-care nutrition tea | |
| CN105920269A (en) | Health-care medicinal liquor for females | |
| CN102580052A (en) | Pilatory and preparation method thereof | |
| CN105995447A (en) | Health-preservation porridge capable of blackening hair and resisting ageing and preparation method of health-preservation porridge | |
| CN101912523A (en) | Traditional Chinese medicine preparation for treating iron-deficiency anemia of children | |
| CN104548049A (en) | Traditional Chinese medicine composition for treating senile osteoporosis and preparation method thereof | |
| CN108403867A (en) | A kind of Traditional Chinese medicine pillow | |
| CN106474240A (en) | The hormonal Traditional Chinese medicine health-preserving preparation of one kind conditioning human body | |
| CN103860430B (en) | A kind of beauty mask and preparation method thereof | |
| CN104782835B (en) | Compound health care medicinal tea suitable for sub-health population | |
| CN105288131A (en) | Traditional Chinese medicine decoction for treating renal tuberculosis and preparation method thereof | |
| CN115518027A (en) | External compound oil for treating sleep disorder and preparation method thereof | |
| CN105796860A (en) | Quick-acting bone setting Yi medicine | |
| CN104645244A (en) | Traditional Chinese medicine composition for treating atherosclerosis | |
| CN105132260A (en) | Health-care wine and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170308 |
|
| RJ01 | Rejection of invention patent application after publication |