CN106421530A - Traditional Chinese medicine for treating diabetes and preparation method - Google Patents
Traditional Chinese medicine for treating diabetes and preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention provides a traditional Chinese medicine for treating diabetes and a preparation method. The traditional Chinese medicine is prepared from, by weight, 2-5 parts of milkvetch roots, 15-25 parts of prepared manyflower solomonseal rhizomes, 12-20 parts of stir-fried rhizoma atractylodis macrocephalae, 17-25 parts of common yam rhizomes, 24-40 parts of coix seeds, 16-25 parts of rhizoma polygonati odorati and 15-25 parts of semen lagenariae sicerariae. All the ingredients of the traditional Chinese medicine is soaked and decocted to obtain a traditional Chinese medicine preparation. The traditional Chinese medicine for treating the diabetes has the effects of benefiting qi, tonifying the spleen, reinforcing the kidney, securing essence, clearing heat and dispersing blood stasis, is used for treating the diabetes and has the advantages of effectively controlling blood glucose and being less in side effect and convenient to use, all the medicines supplement each other, and the effect is excellent.
Description
Technical field
The invention belongs to the field of Chinese medicines is and in particular to a kind of Chinese medicine treating diabetes and preparation method.
Background technology
Diabetes（Diabetes mellitus, DM）It is due to internal hypoinsulinism or effect defect
A kind of common endocrine metabolism disease with sugar, the metabolism disorder such as fat, protein as principal character.In recent years, with people
The factors such as growth in the living standard, living-pattern preservation, the sickness rate rapid development of global diabetes, diabetes are
Through become after tumor, cardiovascular pathological changes the third-largest serious threat human health and life common disease.Diabetes
Clinical manifestation belongs to the category of quenching one's thirst of Chinese medicine, with polyphagia, polydipsia, polyuria, loses weight etc. as common sympton, and with disease
The prolongation of journey, patient gradually feels weakness, and body weight substantially mitigates, and each system damage then（Cardiovascular, cerebrovascular,
Nerve, kidney, eye etc.）A series of performance of late phase clinical, that is, complicated with diabetes nephropathy, diabetic cardiovascular disease become, diabetic
The chronic complicating diseases such as neuropathy, become the main cause of death.
Adopting western medicine treatment diabetes more at present, mainly have insulin secretion stimulators ,-Glucosidase inhibitor
Agent, growth factor antagonist, angiotensin converting enzyme inhibitor etc., such as insulin, biguanideses, sulfonylurea etc., but Western medicine
There is certain limitation and larger side effect, long-term taking is not only larger to liver, injury of kidney, and easily produce drug resistance
Property, it is difficult to fundamentally treat diabetes, lead to the satisfaction rate of patient and its family members low.Therefore, actively find a kind of effect good,
The Chinese medicine of the treatment diabetes of few side effects is that the emphasis of research is located.
Content of the invention
For defect of the prior art, it is an object of the invention to provide the treatment sugar of a kind of effect is significant, Small side effects
Chinese medicine of urine disease and preparation method thereof.
The present invention solves technical problem and adopts the following technical scheme that：
The present invention relates to a kind of Chinese medicine treating diabetes, described Chinese medicine includes each component of following parts by weight：The Radix Astragali 2～
5 parts, 15～25 parts of Rhizoma Polygonati (processed), 12～20 parts of Rhizoma Atractylodis Macrocephalae (parched), 17～25 parts of Rhizoma Dioscoreae, 24～40 parts of Semen Coiciss, 16～25 parts of Rhizoma Polygonati Odorati, calabash
15～25 parts of reed shell.
Preferably, the Chinese medicine of described treatment diabetes, including each component of following parts by weight：3～4 parts of the Radix Astragali, manufacture-yellow
20～25 parts of essence, 15～20 parts of Rhizoma Atractylodis Macrocephalae (parched), 20～25 parts of Rhizoma Dioscoreae, 30～35 parts of Semen Coiciss, 20～25 parts of Rhizoma Polygonati Odorati, calabash shell 20～
25 parts.
Preferably, the Chinese medicine of described treatment diabetes, including each component of following parts by weight：3 parts of the Radix Astragali, Rhizoma Polygonati (processed) 20
Part, 20 parts of Rhizoma Atractylodis Macrocephalae (parched), 25 parts of Rhizoma Dioscoreae, 30 parts of Semen Coiciss, 25 parts of Rhizoma Polygonati Odorati, 20 parts of calabash shell.
Preferably, the Chinese medicine of described treatment diabetes, including each component of following parts by weight：3 parts of the Radix Astragali, Rhizoma Polygonati (processed)
25 parts, 15 parts of Rhizoma Atractylodis Macrocephalae (parched), 20 parts of Rhizoma Dioscoreae, 32 parts of Semen Coiciss, 20 parts of Rhizoma Polygonati Odorati, 20 parts of calabash shell.
The present invention also provides the preparation method of the Chinese medicine of described treatment diabetes, and described preparation method is as follows：By each component
Proportionally mix homogeneously, plus 20～30 DEG C of water soaks 20～30min, puts into boiling machine, decocts 40min, filters off medicinal residues, and will
Medicinal liquid is pressed 150～180ml/ bag and is pressed into Chinese medicine bag, obtains final product, puts 0-8 DEG C of stored refrigerated of refrigerator.
Preferably, the gross weight of described addition water is 10～12 times of Chinese medicine gross weight.
The present invention also provides another kind of preparation method of the Chinese medicine of described treatment diabetes, and described preparation method is as follows：Respectively
After Chinese medicinal components mixing, add 8～10 times of Chinese medicine gross weight of water to soak 0.5～1h, heat decoction 40～50min, filter
Decoction liquor, add the secondary decoction of water of 6～8 times of initial Chinese medicine gross weight in medicinal residues, decoct 30～40min, filter and must decoct
Boil liquid, decoction liquor merging twice is concentrated into relative density for 1.19～1.26（50-60℃）, add 80～95% ethanol to adjust
Section alcohol content reaches 50%, stirs evenly, and stands more than 12h, filtration, filtrate recycling ethanol, is concentrated into the thick paste of no alcohol taste, and decompression is dry
Dry one-tenth dry extract, is adding pharmaceutically acceptable forming agent adjuvant, such as amylum pregelatinisatum, Lactose, dextrin, microcrystalline cellulose, Hard Fat
Sour magnesium, Sodium Hydroxymethyl Stalcses etc., make Chinese medicine preparation.
Preferably, described Chinese medicine preparation includes granule, capsule, tablet.
The Chinese medicine composition for the treatment of diabetes of the present invention, is that inventor is based on oneself clinical experience and to glycosuria for many years
Pathogenetic heightened awareness of disease, obtains through repeatedly optimizing checking.Each component of the Chinese medicine for the treatment of diabetes of the present invention
Pharmacological property as follows：
The Radix Astragali, sweet in the mouth, slight bitter, return lung, spleen, kidney channel, there is tonifying Qi and lifting yang, benefiting QI for strengthening the superficies, promoting blood circulation to remove obstruction in the collateral, spleen reinforcing lung moistening, promote the production of body fluid
Quench the thirst, many effects such as promoting pus discharge and tissue regeneration strengthening and inducing diuresis to remove edema, the Radix Astragali mainly contains glycoside, polysaccharide, aminoacid, trace element and flavone
Deng, can promote organism metabolism, resisting fatigue, enhancing human body immunity function, heart tonifying, arrhythmia, anti-hypoxia, protection cardiovascular and cerebrovascular vessel
Etc. multiple effects；
Rhizoma Polygonati (processed), sweet in the mouth, mild-natured, return lung, spleen, kidney channel, there is the effect of nourishing kidney lung moistening, supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst, for spleen
Stomach is weak, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, Heat Diabetes；
Rhizoma Atractylodis Macrocephalae (parched), bitter in the mouth, sweet, warm in nature, returns spleen, stomach, there is invigorating the spleen and benefiting QI, eliminate dampness and have diuretic effect, effect of strengthening superficial resistance to stop perspiration, can promote
Enter hemopoietic function, the effect such as enhancing human body immunity function, anti-stress, enhancing hemopoietic function；For blood sugar lowering, when extending blood coagulation
Between, suppress platelet aggregation；
Rhizoma Dioscoreae, sweet in the mouth, mild-natured, returns spleen, lung, kidney channel, spleen reinforcing nourishing the stomach, engender liquid and benefic lung, the kidney invigorating arresting seminal emission, for spleen eating less, chronic diarrhea
Incessantly, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst；
Semen Coiciss, property slightly sweet flavor is slightly cold, returns spleen warp, lung meridian, kidney channel, dampness removing spleen invigorating, arthralgia relieving by relaxing muscles and tendons, and clearing away heat and discharging pus can strengthen
Immunity of organisms and antiinflammatory action, also have expansion of blood vessels, fall blood calcium, delaying senility function, for edema, tinea pedis, urine is not
Profit, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis；
Rhizoma Polygonati Odorati, sweet in the mouth, it is slightly cold, attaches to the lung and stomach meridians, there is nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, for lung stomach impairment of yin, cough caused by dryness-heat, dry pharynx
Thirsty, Heat Diabetes；
Calabash shell, sweet in the mouth is mild-natured, GUIXIN, small intestine meridian, inducing diuresis to remove edema, and for edema ascites, the card such as tinea pedis swells and ache, for heat clearing away solution
Poison, lung moistening is convenient.
Each medicine cooperates above, and side becomes the work(of replenishing QI to invigorate the spleen, tonifying the kidney to consolidate the essence, heat clearing and blood stasis dispersing, treating both the principal and secondary aspects of a disease, righting altogether entirely
Eliminating evil, eliminating to treat the excess syndrome, tonifying for deficiency syndrome, blood glucose can be significantly reduced, treat diabetes effect is significant and have no toxic side effect.
Compared with prior art, the present invention has following beneficial effect：The middle medical instrument for the treatment of diabetes of the present invention
There is the work(of replenishing QI to invigorate the spleen, tonifying the kidney to consolidate the essence, heat clearing and blood stasis dispersing, for treating diabetes, there are effective control blood glucose, few side effects, make
Use convenient advantage, each medicine complements each other, and it knowingly follows the example of a wrongdoer evident；Described Chinese medicinal preparation method is simply controlled, can be made into multiple dosage forms, side
Just patient takes.
Specific embodiment
With reference to specific embodiment, the present invention is expanded on further.These embodiments be merely to illustrate the present invention and without
In restriction the scope of the present invention.
Embodiment 1：
The present embodiment is related to a kind of Chinese medicine treating diabetes and preparation method；
The Chinese medicine of described treatment diabetes includes each component of following parts by weight：3 parts of the Radix Astragali, 25 parts of Rhizoma Polygonati (processed), Rhizoma Atractylodis Macrocephalae (parched) 15
Part, 20 parts of Rhizoma Dioscoreae, 32 parts of Semen Coiciss, 20 parts of Rhizoma Polygonati Odorati, 20 parts of calabash shell.
Described Chinese medicinal preparation method is as follows：By each component proportionally mix homogeneously, plus 20 DEG C of 12 times of Chinese medicine gross weight
Water soak 30min, put into boiling machine, decoct 40min, filter off medicinal residues, medicinal liquid press 180ml/ bag and is pressed into Chinese medicine bag, obtain final product,
Put 0-8 DEG C of stored refrigerated of refrigerator.
Embodiment 2：
The present embodiment is related to a kind of Chinese medicine treating diabetes and preparation method；
The Chinese medicine of described treatment diabetes includes each component of following parts by weight：3 parts of the Radix Astragali, 20 parts of Rhizoma Polygonati (processed), Rhizoma Atractylodis Macrocephalae (parched) 20
Part, 25 parts of Rhizoma Dioscoreae, 30 parts of Semen Coiciss, 25 parts of Rhizoma Polygonati Odorati, 20 parts of calabash shell.
Described Chinese medicinal preparation method is as follows：By each component proportionally mix homogeneously, plus 30 DEG C of 10 times of Chinese medicine gross weight
Water soak 20min, put into boiling machine, decoct 40min, filter off medicinal residues, medicinal liquid press 150ml/ bag and is pressed into Chinese medicine bag, obtain final product,
Put 0-8 DEG C of stored refrigerated of refrigerator.
Embodiment 3：
The present embodiment is related to a kind of Chinese medicine treating diabetes and preparation method；
The Chinese medicine of described treatment diabetes includes each component of following parts by weight：5 parts of the Radix Astragali, 15 parts of Rhizoma Polygonati (processed), Rhizoma Atractylodis Macrocephalae (parched) 20
Part, 25 parts of Rhizoma Dioscoreae, 40 parts of Semen Coiciss, 25 parts of Rhizoma Polygonati Odorati, 25 parts of calabash shell.
Described Chinese medicinal preparation method is as follows：By each component proportionally mix homogeneously, plus 30 DEG C of 10 times of Chinese medicine gross weight
Water soak 20min, put into boiling machine, decoct 40min, filter off medicinal residues, medicinal liquid press 160ml/ bag and is pressed into Chinese medicine bag, obtain final product,
Put 0-8 DEG C of stored refrigerated of refrigerator.
Embodiment 4：
The present embodiment is related to a kind of Chinese medicine treating diabetes and preparation method；
The Chinese medicine of described treatment diabetes includes each component of following parts by weight：4 parts of the Radix Astragali, 25 parts of Rhizoma Polygonati (processed), Rhizoma Atractylodis Macrocephalae (parched) 15
Part, 25 parts of Rhizoma Dioscoreae, 35 parts of Semen Coiciss, 25 parts of Rhizoma Polygonati Odorati, 20 parts of calabash shell.
Described Chinese medicinal preparation method is as follows：After each Chinese medicinal components mixing, 8 times of Chinese medicine gross weight of water is added to soak 1h,
Heating decocts 40min, filters to obtain decoction liquor, adds the secondary decoction of water of 8 times of initial Chinese medicine gross weight in medicinal residues, decocts
40min, filters to obtain decoction liquor, and decoction liquor merging twice is concentrated into relative density for 1.19（50℃）, add 95% ethanol to adjust
Section alcohol content reaches 50%, stirs evenly, and stands more than 12h, filtration, filtrate recycling ethanol, is concentrated into the thick paste of no alcohol taste, and decompression is dry
Dry one-tenth dry extract, adds Lactose and dextrin, wet granulation, obtains granule.
Embodiment 5：
The present embodiment is related to a kind of Chinese medicine treating diabetes and preparation method；
The Chinese medicine of described treatment diabetes includes each component of following parts by weight：3 parts of the Radix Astragali, 22 parts of Rhizoma Polygonati (processed), Rhizoma Atractylodis Macrocephalae (parched) 20
Part, 21 parts of Rhizoma Dioscoreae, 30 parts of Semen Coiciss, 22 parts of Rhizoma Polygonati Odorati, 22 parts of calabash shell.
Described Chinese medicine preparation process is as follows：After each Chinese medicinal components mixing, 10 times of Chinese medicine gross weight of water is added to soak
0.5, heating decocts 50min, filters to obtain decoction liquor, adds the secondary decoction of water of 6 times of initial Chinese medicine gross weight in medicinal residues, decocts
30min, filters to obtain decoction liquor, and decoction liquor merging twice is concentrated into relative density for 1.26（60℃）, add 80% ethanol to adjust
Section alcohol content reaches 50%, stirs evenly, and stands more than 12h, filtration, filtrate recycling ethanol, is concentrated into the thick paste of no alcohol taste, and decompression is dry
Dry one-tenth dry extract, adds amylum pregelatinisatum and magnesium stearate, pelletize, tabletting, prepared tablet.
Clinical data：
Physical data：All of diabetes（II type）Patient 70, all patients are randomly divided into treatment group and matched group each 35
Example, wherein treatment group man 20, female 15, at 33～65 years old age, the mean age is 46.3 years old, the course of disease 0.5～8 year, averagely disease
Journey is 5.1 years；Matched group man 21, female 14,30～66 years old age, the course of disease 0.5～8 year, average course of disease is 4.8 years；Two groups
The aspects such as Gender, age, the course of disease are relatively showed no significant difference.
Diagnostic criteria is developed and published with reference to Ministry of Health of the People's Republic of China《New Chinese medicine treats diabetes clinical research
Guideline》：
Primary symptom：Fatigue weak, thirst and liking drink.
Secondary disease：Spontaneous perspiration or night sweat, the lazy speech of shortness of breath, palpitation and insomnia, soreness of the waist and knees, polyuria.
Tongue pulse condition：Light red tongue is dark or red dark, or Sublingual blue veins purple is secretly tortuous obvious, indented tongue margin, the few Tianjin of white and thin fur, or few
Tongue, thready and weak pulse.
Test method
Treatment group is administered orally the decoct that the present invention is obtained according to specific embodiment 1, and 2 times a day, sooner or later respectively once, one after each meal,
It is within one month 1 each course for the treatment of, observe 2 courses for the treatment of.
Matched group is administered orally diabetes pill, uses according to its description, the course for the treatment of 2 months.
Curative effect determinate standard
Cure：Clinical symptoms polydipsia, polyphagia, polyuria disappear, and chemically examine fasting glucose ＜ 6.3mmol/L, glucose in urine（-）；
Effective：Tcm clinical practice symptom, sign disappear, and chemically examine fasting glucose ＜ 7.0mmol/L, glucose in urine（-）；
Effectively：Tcm clinical practice symptom, sign all take a favorable turn, and chemically examine fasting glucose ＜ 8.5mmol/L, glucose in urine（-）；
Invalid：Fasting glucose ＞ 12mmol/L, glucose in urine（+）Or blood glucose rise after treatment.
Therapeutic outcome, see table.
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate | Side effect |
| Treatment group | 35 | 25 | 5 | 2 | 3 | 91.4% % | Have no |
| Matched group | 35 | 15 | 7 | 5 | 8 | 77.1% | Have no |
The Chinese medicine for the treatment of diabetes of the present invention has the work(of replenishing QI to invigorate the spleen, tonifying the kidney to consolidate the essence, heat clearing and blood stasis dispersing, for treating
Diabetes, have the advantages that effective control blood glucose, few side effects, easy to use, each medicine complements each other, and it knowingly follows the example of a wrongdoer evident.
Above the specific embodiment of the present invention is described.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, those skilled in the art can make various modifications or modification within the scope of the claims, this not shadow
Ring the flesh and blood of the present invention.
Claims (8)
1. a kind of Chinese medicine treating diabetes it is characterised in that：Described Chinese medicine includes each component of following parts by weight：The Radix Astragali
2～5 parts, 15～25 parts of Rhizoma Polygonati (processed), 12～20 parts of Rhizoma Atractylodis Macrocephalae (parched), 17～25 parts of Rhizoma Dioscoreae, 24～40 parts of Semen Coiciss, Rhizoma Polygonati Odorati 16～25
Part, 15～25 parts of calabash shell.
2. according to claim 1 treatment diabetes Chinese medicine it is characterised in that：Described Chinese medicine includes following weight portion
Each component of number：3～4 parts of the Radix Astragali, 20～25 parts of Rhizoma Polygonati (processed), 15～20 parts of Rhizoma Atractylodis Macrocephalae (parched), 20～25 parts of Rhizoma Dioscoreae, Semen Coiciss 30～35
Part, 20～25 parts of Rhizoma Polygonati Odorati, 20～25 parts of calabash shell.
3. according to claim 2 treatment diabetes Chinese medicine it is characterised in that：Described Chinese medicine includes following weight portion
Each component of number：3 parts of the Radix Astragali, 20 parts of Rhizoma Polygonati (processed), 20 parts of Rhizoma Atractylodis Macrocephalae (parched), 25 parts of Rhizoma Dioscoreae, 30 parts of Semen Coiciss, 25 parts of Rhizoma Polygonati Odorati, calabash shell
20 parts.
4. according to claim 2 treatment diabetes Chinese medicine it is characterised in that：Described Chinese medicine includes following weight portion
Each component of number：3 parts of the Radix Astragali, 25 parts of Rhizoma Polygonati (processed), 15 parts of Rhizoma Atractylodis Macrocephalae (parched), 20 parts of Rhizoma Dioscoreae, 32 parts of Semen Coiciss, 20 parts of Rhizoma Polygonati Odorati, calabash shell
20 parts.
5. a kind of as any one of claim 1-4 treat diabetes Chinese medicine preparation method it is characterised in that：Described
Preparation method is as follows：By each component proportionally mix homogeneously, plus 20～30 DEG C of water soaks 20～30min, puts into boiling machine,
Decoct 40min, filter off medicinal residues, medicinal liquid is pressed 150～180ml/ bag and is pressed into Chinese medicine bag, obtain final product.
6. according to claim 5 treatment diabetes Chinese medicine preparation method it is characterised in that：The described gross weight adding water
Measure 10～12 times for Chinese medicine gross weight.
7. a kind of as any one of claim 1-4 treat diabetes de Chinese medicine preparation method it is characterised in that：Described
Preparation method is as follows：After each Chinese medicinal components mixing, add the water of 8～10 times of Chinese medicine gross weight to soak 0.5～1h, heat decoction 40
～50min, filters to obtain decoction liquor, adds the secondary decoction of water of 6～8 times of initial Chinese medicine gross weight in medicinal residues, decoct 30～
40min, filters to obtain decoction liquor, and decoction liquor merging twice is concentrated into relative density for 1.19～1.26（50-60℃）, add 80
～95% ethanol adjusts alcohol content and reaches 50%, stirs evenly, and stands more than 12h, filtration, filtrate recycling ethanol, is concentrated into no alcohol taste
Thick paste, drying under reduced pressure becomes dry extract, is adding pharmaceutically acceptable forming agent adjuvant, is making Chinese medicine preparation.
8. according to claim 7 treatment diabetes Chinese medicine preparation method it is characterised in that：Described Chinese medicine preparation includes
Granule, capsule, tablet.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055198A (en) * | 2012-12-24 | 2013-04-24 | 林学荣 | Medicine for treating diabetes mellitus and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055198A (en) * | 2012-12-24 | 2013-04-24 | 林学荣 | Medicine for treating diabetes mellitus and preparation method thereof |
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| Title |
|---|
| 顾锂铀等: "秦亮甫教授运用膏方治疗糖尿病的经验", 《吉林中医药》 * |
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