CN106421309A - 治疗类风湿性关节炎的药物 - Google Patents

治疗类风湿性关节炎的药物 Download PDF

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CN106421309A
CN106421309A CN201611070498.4A CN201611070498A CN106421309A CN 106421309 A CN106421309 A CN 106421309A CN 201611070498 A CN201611070498 A CN 201611070498A CN 106421309 A CN106421309 A CN 106421309A
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黄凤玲
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Abstract

本发明提供一种类风湿性关节炎的药物，由桂枝、白芍、生黄芪、威灵仙、知母、制附子、秦艽、鸡血藤、红花、麻黄、防风、川黄柏、生甘草、生地、地龙、骨碎补、桑寄生、皂角刺、狗脊等原料制得。本发明的原料为常用中草药，来源广泛、价格便宜、药物配方科学合理、各组分之间协同作用，能养血活血、通经活络、消肿止痛。对类风湿性关节炎具有较好的治疗效果。

Description

治疗类风湿性关节炎的药物
技术领域
本发明涉及一种治疗类风湿性关节炎的药物，属于中药技术领域。
背景技术
类风湿性关节炎是一种以关节和关节周围组织的非感染性炎症为主的全身性疾病。常累及其它脏器，引起心包炎、心肌炎、间质性肺炎、肾淀粉样变及眼部疾患等。其关节症状特点为关节滑膜发生炎症、渗液、细胞增殖、软骨及骨组织破坏，最后关节强直，关节功能丧失。本病属于中医学的“历节病”“痹证”等范畴。现在市场治疗类风湿性关节炎的药物以西药为主，这些西药具有价格高、副作用大等缺点，其治标不治本，需长期服用，一停药易复发，治疗效果不能令人满意。
发明内容
本发明要解决的技术问题是：提供一种治疗类风湿性关节炎的药物，具有价格便宜、治疗效果好、毒副作用小等优点。
为解决上述技术问题，本发明采用一下技术方案：
治疗类风湿性关节炎的药物，由下述重量份的原料制得：桂枝6-10份、白芍6-10份、生黄芪20-30份、威灵仙15-25份、知母8-10份、制附子10-20份、秦艽6-10份、鸡血藤6-10份、红花8-10份、麻黄8-10份、防风6-10份、川黄柏8-10份、生甘草8-10份、生地16-20份、地龙16-20份、骨碎补16-20份、桑寄生11-15份、皂角刺5-10份、狗脊5-10份。
作为优选的，这里给出第一个具体配方，所述原料的重量份为：桂枝6份、白芍6份、生黄芪20份、威灵仙25份、知母10份、制附子10份、秦艽8份、鸡血藤8份、红花8份、麻黄10份、防风6份、川黄柏9份、生甘草10份、生地20份、地龙20份、骨碎补16份、桑寄生13份、皂角刺8份、狗脊8份。
作为优选的，这里给出第二个具体配方，所述原料的重量份为：桂枝8份、白芍10份、生黄芪25份、威灵仙20份、知母8份、制附子20份、秦艽10份、鸡血藤10份、红花10份、麻黄8份、防风8份、川黄柏10份、生甘草8份、生地16份、地龙16份、骨碎补20份、桑寄生11份、皂角刺5份、狗脊10份。
作为优选的，这里给出第三个具体配方，所述原料的重量份为：桂枝10份、白芍8份、生黄芪30份、威灵仙15份、知母9份、制附子15份、秦艽6份、鸡血藤6份、红花9份、麻黄9份、防风10份、川黄柏8份、生甘草6份、生地18份、地龙18份、骨碎补18份、桑寄生15份、皂角刺10份、狗脊5份。
本发明还提供上述药物的制备方法，其步骤如下：将原料用体积浓度为30％-60％的酒精浸泡0.1-0.5小时，取出用水冲洗，置于其浸泡前重量3-5倍的水中，加热至沸腾后，在微沸状态下煎煮0.5-1小时，过滤，滤液浓缩至其体积的30％-40％，加入浓缩液重量1％-3％的变性淀粉，喷雾干燥后，即得到该药物。
该药物的使用方法为：将药物加入温水中冲服，每次的用量为1-5克，一天服用3次。
本发明的有益效果是：本发明的原料为常用中草药，来源广泛、价格便宜、药物配方科学合理、各组分之间协同作用，能养血活血、通经活络、消肿止痛，对类风湿性关节炎具有较好的治疗效果。用此方治疗类风湿性关节炎患者39例，经过3-6月的治疗，基本痊愈28例、显效5例、有效4例、无效2例。总有效率为95％以上，且无任何患者出现不良反应，说明本发明的药物见效快、疗效好。
具体实施方式
以下通过实施例进一步说明本发明，但不限于这些实施例。
实施例1
治疗类风湿性关节炎的药物，由下述重量份的原料制得：桂枝6份、白芍6份、生黄芪20份、威灵仙25份、知母10份、制附子10份、秦艽8份、鸡血藤8份、红花8份、麻黄10份、防风6份、川黄柏9份、生甘草10份、生地20份、地龙20份、骨碎补16份、桑寄生13份、皂角刺8份、狗脊8份。
药物的制备方法为：将原料用体积浓度为30％的酒精浸泡0.3小时，取出用水冲洗，置于其浸泡前重量5倍的水中，加热至沸腾后，在微沸状态下煎煮0.5小时，过滤，滤液浓缩至其体积的35％，加入浓缩液重量3％的变性淀粉，喷雾干燥后，即得该药物。
实施例2
治疗类风湿性关节炎的药物，由下述重量份的原料制得：桂枝8份、白芍10份、生黄芪25份、威灵仙20份、知母8份、制附子20份、秦艽10份、鸡血藤10份、红花10份、麻黄8份、防风8份、川黄柏10份、生甘草8份、生地16份、地龙16份、骨碎补20份、桑寄生11份、皂角5份、狗脊10份。
药物的制备方法为：将原料用体积浓度为50％的酒精浸泡0.5小时，取出用水冲洗，置于其浸泡前重量3倍的水中，加热至沸腾后，在微沸状态下煎煮0.8小时，过滤，滤液浓缩至其体积的40％，加入浓缩液重量1％的变性淀粉，喷雾干燥后，即得到该药物。
实施例3
治疗类风湿性关节炎的药物，由下述重量份的原料制得：桂枝10份、白芍8份、生黄芪30份、威灵仙15份、知母9份、制附子15份、秦艽6份、鸡血藤6份、红花9份、麻黄9份、防风10份、川黄柏8份、生甘草6份、生地18份、地龙18份、骨碎补18份、桑寄生15份、皂角刺10份、狗脊5份。
药物的制备方法为：将原料用体积浓度为60％的酒精浸泡0.5小时，取出用水冲洗，置于其浸泡前重量4倍的水中，加热至沸腾后，在微沸状态下煎煮1小时，过滤，滤液浓缩至其体积的30％，加入浓缩液重量2％的变性淀粉，喷雾干燥后，即得到该药物。
毒性实验
实验药品时本发明实施例1中的药物。实验动物ICR小白鼠，体重20-25克，雌雄各半，共40只。实验方法是：禁食15小时后，按10g/kg给小白鼠灌胃4个月。长期毒性实验结果显示：小白鼠体重、肝功能、肾功能、血液等与对照组无明显差异。表明该药的安全性大，属于无毒级别。
典型病例
病例1，张XX，女，16岁，学生，已四肢关节肿痛四年，关节变形，活动受限加重两个月。用实施例1制的药物治疗半年，肿消病减，功能恢复正常，继续服药巩固疗效。一年后复查，一切正常。
病例2，刘XX，女，30岁，公司职员，四年前因感冒发热后觉双膝关节疼痛，后渐及双踝、骨宽、肩、肘、腕等关节肿胀、灼热、疼痛。用实施例2制得的药物治疗3个月，肿痛减轻，继续服药巩固疗效。半年后复查，一切正常。
病例3，周XX，男，60岁，退休教师，下肢关节肿痛5年，活动受限，走路用拐杖。用实施例3制得的药物治疗，服药6个月肿痛消失，活动自如，走路不用拐杖，继续服药巩固疗效。一年后，无复发，一切正常。

Claims (5)

1.治疗类风湿性关节炎的药物，其特征在于，由下述重量份的原料制得：桂枝6-10份、白芍6-10份、生黄芪20-30份、威灵仙15-25份、知母8-10份、制附子10-20份、秦艽6-10份、鸡血藤6-10份、红花8-10份、麻黄8-10份、防风6-10份、川黄柏8-10份、生甘草8-10份、生地16-20份、地龙16-20份、骨碎补16-20份、桑寄生11-15份、皂角刺5-10份、狗脊5-10份。
2.根据权利要求1所述的药物，其特征在于，所述原料的重量份为：桂枝6份、白芍6份、生黄芪20份、威灵仙25份、知母10份、制附子10份、秦艽8份、鸡血藤8份、红花8份、麻黄10份、防风6份、川黄柏9份、生甘草10份、生地20份、地龙20份、骨碎补16份、桑寄生13份、皂角刺8份、狗脊8份。
3.根据权利要求1所述的药物，其特征在于，所述原料的重量份为：桂枝8份、白芍10份、生黄芪25份、威灵仙20份、知母8份、制附子20份、秦艽10份、鸡血藤10份、红花10份、麻黄8份、防风8份、川黄柏10份、生甘草8份、生地16份、地龙16份、骨碎补20份、桑寄生11份、皂角刺5份、狗脊10份。
4.根据权利要求1所述的药物，其特征在于，所述原料的重量份为：桂枝10份、白芍8份、生黄芪30份、威灵仙15份、知母9份、制附子15份、秦艽6份、鸡血藤6份、红花9份、麻黄9份、防风10份、川黄柏8份、生甘草6份、生地18份、地龙18份、骨碎补18份、桑寄生15份、皂角刺10份、狗脊5份。
5.根据权利要求1-4中任一项所述的药物，其特征在于，药物的制备方法为：将原料用体积浓度为30％-60％的酒精浸泡0.1-0.5小时，取出用水冲洗，置于其浸泡前重量3-5倍的水中，加热至沸腾后，在微沸状态下煎煮0.5-1小时，过滤，滤液浓缩至其体积的30％-40％，加入浓缩液重量1％-3％的变性淀粉，喷雾干燥后，即得到该药物。
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