CN106421239A - Medicine for treating stroke and preparation method thereof - Google Patents

Medicine for treating stroke and preparation method thereof Download PDF

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Publication number
CN106421239A
CN106421239A CN201611058142.9A CN201611058142A CN106421239A CN 106421239 A CN106421239 A CN 106421239A CN 201611058142 A CN201611058142 A CN 201611058142A CN 106421239 A CN106421239 A CN 106421239A
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parts
medicine
rhizoma
preparation
apoplexy
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莫泽庸
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a medicine for treating stroke and a preparation method of the medicine. The medicine comprises, by weight, 100-160 parts of rhizoma typhonii, 30-40 parts of radix aconitum, 10-20 parts of semen plantaginis, 15-25 parts of processed rhizoma pinelliae, 10-20 parts of lindera glauca, 10-20 parts of frankincense, 8- 10 parts of mangnolia officinalis, 12-14 parts of radix angelicae pubescentis, 10-20 parts of raspberry, 10-20 parts of poria cocos, and 8-10 parts of coptis. The preparation method is to put the medicine into the pot, add 1000 to 1500 parts of water, boiling for 25 to 35 minutes, and taking the filtrate; to add 1000 to 1500 parts of water in dregs, boiling for 25 to 35 minutes, and combining filtrate obtained twice and uniformly mixing. The medicine has good curative effect on stroke, cerebral thrombosis, cerebral infarction, hemiplegia and sequelae of encephalopathy without any toxic and side effects, and the preparation method is simple and easy to operate. In 150 clinical treatment cases, markedly effective rate is up to 80%.

Description

A kind of treat medicine of apoplexy and preparation method thereof
Technical field
The invention belongs to technical field of Chinese medicines, relate in particular to a kind of medicine treating apoplexy, also relate to its system Preparation Method.
Background technology
Apoplexy is one group of disease with cerebral ischemic and heamorrhagic lesions symptom as main clinical manifestation, also known as apoplexy or Cerebrovas-cularaccident, has high case fatality rate and disability rate, and (cerebral hemorrhage or subarachnoid space go out to be broadly divided into hemorrhagic cerebral apoplexy Blood) and ischemia apoplexy (cerebral infarction, cerebral thrombosiss) two big class, most commonly seen with cerebral infarction.Apoplexy morbidity is anxious, dies of illness Rate is high, is one of most important fatal disease in the world.Whether cerebral infarction or hemorrhagic apoplexy, all can cause not Co-extensive, different degrees of brain tissue damage, thus produce diversified neuro-psychiatric symptom, serious goes back entail dangers to life Life, after healing, a lot of patients leave sequela.Therefore, apoplexy is the formidable enemy of harm human health.Treatment currently for apoplexy Method has dietetic therapy, acupuncture, oral Chinese and Western patent medicine etc..Western medicine have the advantages that rapid-action, with strong points, but its model of action list One, and drug resistance and side effect can be produced.
Content of the invention
A kind of it is an object of the invention to provide cheap, effect is significant, and the medicine of the treatment apoplexy having no side effect.
Another object of the present invention is to providing the preparation method of the medicine of this treatment apoplexy.
A kind of medicine treating apoplexy of the present invention, by weight, including following raw material：
Rhizoma Typhonii 100-160 part, Radix Aconiti 30-40 part, Semen Plantaginiss 10-20 part, Rhizoma Pinelliae Preparata 15-25 part, Fructus Linderae Glaucae 10-20 part, Olibanum 10-20 part, Cortex Magnoliae Officinalis 8-10 part, Radix Angelicae Pubescentiss 12-14 part, Fructus Rubi 10-20 part, Poria 10-20 part, Rhizoma Coptidis 8-10 part.
A kind of above-mentioned medicine treating apoplexy, preferably each parts by weight of raw materials is as follows：
130 parts of Rhizoma Typhonii, 35 parts of Radix Aconiti, 15 parts of Semen Plantaginiss, 20 parts of Rhizoma Pinelliae Preparata, 15 parts of Fructus Linderae Glaucae, 15 parts of Olibanum, 9 parts of Cortex Magnoliae Officinalis, 13 parts of Radix Angelicae Pubescentiss, 15 parts of Fructus Rubi, 15 parts of Poria, 9 parts of Rhizoma Coptidis.
A kind of preparation method of medicine treating apoplexy of the present invention, comprises the following steps：
（1）By the sampling of following weight portion：Rhizoma Typhonii 100-160 part, Radix Aconiti 30-40 part, Semen Plantaginiss 10-20 part, Rhizoma Pinelliae Preparata 15- 25 parts, Fructus Linderae Glaucae 10-20 part, Olibanum 10-20 part, Cortex Magnoliae Officinalis 8-10 part, Radix Angelicae Pubescentiss 12-14 part, Fructus Rubi 10-20 part, Poria 10-20 Part, Rhizoma Coptidis 8-10 part.
（2）Medical material is put in pot, adds 1000-1500 part water, decoct 25-35 minute, take filtrate；To in medicinal residues again Add 1000-1500 part water, decoct 25-35 minute, will twice filtrate merge after, mix homogeneously obtains final product.
Compared with prior art, the present invention selects Rhizoma Typhonii, Radix Aconiti, Semen Plantaginiss, Rhizoma Pinelliae Preparata, mountain recklessly to the medicine of the present invention Green pepper, Olibanum, Cortex Magnoliae Officinalis, Radix Angelicae Pubescentiss, Fructus Rubi, Poria, Rhizoma Coptidis are used as medicine, by all medicine reasonable compatibilities, complementary collaborative, and dialectical treatment is right In diseases such as apoplexy, cerebral thrombosiss, cerebral infarction, hemiplegia and encephalopathy sequelas, there is obvious beneficial effect, evident in efficacy, no any Toxic and side effects, the preparation method of employing is simple, easily operated.Clinical treatment case 150, obvious effective rate 80%.
Specific embodiment
The beneficial effect of of the present invention medicine is expanded on further below by way of test example.
Test example：The clinical observation of medicine of the present invention
1st, case selection
Treatment case 150, wherein：One full year of life at age 40～70, wherein man 80, female 70.
2nd, disease
（1）Cerebral infarction：Often fall ill under rest state, morbidity is hurried, most nothings substantially premonitory symptom such as headache, vomiting； Have carotid artery system or（With）The sings and symptoms of vertebra-basilar artery system；Cerebral angiography inspection shows different parts brain Stricture of artery, obturation or distortion.Radiography is taken the photograph and should be included cervical region during piece；Apoplectic seizure 24-48 is little for Ischemia Injury in Brain Shi Hou, Cranial Computed Tomography can show ischemia focus.Nuclear magnetic resonance check points out the narrow and inaccessible of Arterial system；Local cerebral blood flow is surveyed Fixed, local cerebral ischemia pathological changes can be pointed out.
（2）Hemorrhagic apoplexy：Previously there is hypertensive arteriosclerosis medical history；Disturbance of consciousness and hemiplegia occur suddenly；CT table It is now high density shadow zone, bleeding can ventricular extension.Clinically whether, whether gone into a coma according to patient's Consciousness, hemiplegia degree etc. Hemorrhagic apoplexy is divided into three-level..
3rd, Therapeutic Method：
Oral gained medicine of the present invention, 3 times a day, each 50ml, is within 15 days 1 course for the treatment of, the 3-4 course for the treatment of.
4th, curative effect determinate standard
Effective：Symptomatology substantially eliminates or cardinal symptom eliminates.
Effectively：Cardinal symptom substantially eliminates or is obviously improved.
Invalid：Various symptoms and sign no change.
5th, therapeutic outcome：
Patient use medicine of the present invention, effective 120, effective 10, invalid 20, obvious effective rate 69%, total effective rate 86.7%.
Illustrate the preparation method of this medicine by following examples.
Embodiment 1：
A kind of preparation method of the medicine treating apoplexy, comprises the following steps：
（1）Weigh：Rhizoma Typhonii 100g, Radix Aconiti 40g, Semen Plantaginiss 10g, Rhizoma Pinelliae Preparata 25g, Fructus Linderae Glaucae 10g, Olibanum 20g, Cortex Magnoliae Officinalis 80g, Radix Angelicae Pubescentiss 14g, Fructus Rubi 10g, Poria 20g, Rhizoma Coptidis 10g.
（2）Medical material is put in pot, adds 1000g water, decoct 35 minutes, take filtrate；Add 1500g in medicinal residues Water, decoct 25 minutes, will twice filtrate merge after, mix homogeneously obtains final product.
Embodiment 2：
A kind of treat medicine of apoplexy and preparation method thereof, comprise the following steps：
（1）Weigh：Rhizoma Typhonii 130g, Radix Aconiti 35g, Semen Plantaginiss 15g, Rhizoma Pinelliae Preparata 20g, Fructus Linderae Glaucae 15g, Olibanum 15g, Cortex Magnoliae Officinalis 9g, Radix Angelicae Pubescentiss 13g, Fructus Rubi 15g, Poria 15g, Rhizoma Coptidis 9g.
（2）Medical material is put in pot, adds 1250g water, decoct 30 minutes, take filtrate；Add 1250g in medicinal residues Water, decoct 30 minutes, will twice filtrate merge after, mix homogeneously obtains final product.
Embodiment 3：
A kind of preparation method of the medicine treating apoplexy, comprises the following steps：
（1）Weigh：Rhizoma Typhonii 160g, Radix Aconiti 30g, Semen Plantaginiss 20g, Rhizoma Pinelliae Preparata 15g, Fructus Linderae Glaucae 20g, Olibanum 10g, Cortex Magnoliae Officinalis 10g, Radix Angelicae Pubescentiss 12g, Fructus Rubi 20g, Poria 10g, Rhizoma Coptidis 8g.
（2）Medical material is put in pot, adds 1500g water, decoct 25 minutes, take filtrate；Add 1000g in medicinal residues Water, decoct 35 minutes, will twice filtrate merge after, mix homogeneously obtains final product.
The above, be only presently preferred embodiments of the present invention, not the present invention is made with any pro forma restriction, appoints What any is simply repaiied according to what the technical spirit of the present invention made to above example without departing from technical solution of the present invention content Change, equivalent variations and modification, all still fall within the range of technical solution of the present invention.

Claims (3)

1. a kind of medicine treating apoplexy, by weight, including following raw material：
Rhizoma Typhonii 100-160 part, Radix Aconiti 30-40 part, Semen Plantaginiss 10-20 part, Rhizoma Pinelliae Preparata 15-25 part, Fructus Linderae Glaucae 10-20 part, Olibanum 10-20 part, Cortex Magnoliae Officinalis 8-10 part, Radix Angelicae Pubescentiss 12-14 part, Fructus Rubi 10-20 part, Poria 10-20 part, Rhizoma Coptidis 8-10 part.
2. the medicine for the treatment of apoplexy as claimed in claim 1, by weight, including following raw material：
130 parts of Rhizoma Typhonii, 35 parts of Radix Aconiti, 15 parts of Semen Plantaginiss, 20 parts of Rhizoma Pinelliae Preparata, 15 parts of Fructus Linderae Glaucae, 15 parts of Olibanum, 9 parts of Cortex Magnoliae Officinalis, 13 parts of Radix Angelicae Pubescentiss, 15 parts of Fructus Rubi, 15 parts of Poria, 9 parts of Rhizoma Coptidis.
3. a kind of preparation method of the medicine treating apoplexy, comprises the following steps：
（1）By the sampling of following weight portion：Rhizoma Typhonii 100-160 part, Radix Aconiti 30-40 part, Semen Plantaginiss 10-20 part, Rhizoma Pinelliae Preparata 15- 25 parts, Fructus Linderae Glaucae 10-20 part, Olibanum 10-20 part, Cortex Magnoliae Officinalis 8-10 part, Radix Angelicae Pubescentiss 12-14 part, Fructus Rubi 10-20 part, Poria 10-20 Part, Rhizoma Coptidis 8-10 part；
（2）Medical material is put in pot, adds 1000-1500 part water, decoct 25-35 minute, take filtrate；Add in medicinal residues 1000-1500 part water, decoct 25-35 minute, will twice filtrate merge after, mix homogeneously obtains final product.
CN201611058142.9A 2016-11-27 2016-11-27 Medicine for treating stroke and preparation method thereof Pending CN106421239A (en)

Priority Applications (1)

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Application Number Priority Date Filing Date Title
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1161229A (en) * 1997-01-23 1997-10-08 陈宝朝 Traditional Chinese medicine for treating apoplexy and method for preparing same
CN1265309A (en) * 2000-01-14 2000-09-06 云南滇北制药有限公司 Medicine for rheumatism and aploplexy and its preparation
CN104288394A (en) * 2014-09-17 2015-01-21 河南中医学院 Traditional Chinese medicine composition for treating stroke and hemiplegia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1161229A (en) * 1997-01-23 1997-10-08 陈宝朝 Traditional Chinese medicine for treating apoplexy and method for preparing same
CN1265309A (en) * 2000-01-14 2000-09-06 云南滇北制药有限公司 Medicine for rheumatism and aploplexy and its preparation
CN104288394A (en) * 2014-09-17 2015-01-21 河南中医学院 Traditional Chinese medicine composition for treating stroke and hemiplegia

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
任犀然: "《神农本草经（第一版）》", 30 September 2016, 北京联合出版公司 *
南劲松 等: "《南征用药心得十讲（第一版）》", 30 April 2006, 中国医药科学出版社 *
国药编委会主编: "《中医名方灵方大全（第一版）》", 31 January 2016, 黑龙江科学技术出版社 *
杨卫平等: "《特色中草药及配方（第一版）》", 31 August 2016, 贵州出版集团 *
贾宪亭 等: "《实用中药类编 下（第一版）》", 30 October 2015, 中州古籍出版社 *
郁东海等: "《全国医疗服务价格中医项目技术操作指南（第1版）》", 30 June 2016, 上海科学技术出版社 *
黄跃东 等: "《200种常见疾病的中草药治疗（第一版）》", 28 February 2007, 上海科学技术出版社 *

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Application publication date: 20170222