CN106420869A - Pretreatment method for improving clarity of panax notoginseng saponin raw material medicine for injection - Google Patents
Pretreatment method for improving clarity of panax notoginseng saponin raw material medicine for injection Download PDFInfo
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- CN106420869A CN106420869A CN201610749377.6A CN201610749377A CN106420869A CN 106420869 A CN106420869 A CN 106420869A CN 201610749377 A CN201610749377 A CN 201610749377A CN 106420869 A CN106420869 A CN 106420869A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a pretreatment method for improving clarity of panax notoginseng saponin raw material medicine for injection, and relates to a production method of medicine, in particular to a production method for improving clarity of injection. The treatment method for improving clarity of panax notoginseng saponin raw material medicine for the injection is a result after many years of production experience of panax notoginseng saponin and a long period of laboratory study, particularly the pretreatment method of an extracting liquid invented in manufacturing technique of injection panax notoginseng saponin before the liquid passes through a quartz column. The method can effectively remove macromolecule impurities of sediment, pigment and the like and most fat soluble impurities. After treatment by the adoption of the method, separation and purification of later resin are promoted, production need of injection panax notoginseng saponin raw material is met, moreover, the method is mainly a physical method, and no unfavorable effects are caused to the effective constituent; in the method, water sedimentation and centrifugal filtration effectively remove fat soluble impurities, afterwards the purpose of passing through the quartz column is to guarantee that fat soluble impurities which cannot be fully removed by procedures of water sedimentation and centrifugal filtration are removed, and part of pigment impurities can be further removed. The treatment method for improving clarity of panax notoginseng saponin raw material medicine for the injection has a simple technology and a remarkable effect.
Description
Technical field
The present invention relates to a kind of production method of medicine, particularly to a kind of production method improving clarity of injection.
Background technology
A project indicator is had to be extremely difficult to require at present during injection arasaponin production of raw medicine in industry,
I.e. clarity（Medicinal by ejection preparation compound method, after being made into）Why difficulty reaches requirement to this project, and crucial factor is exactly
During extraction is detached, impurity component is difficult to efficiently separate in claimed range.In industry, arasaponin extracts and separated
35 roads are probably had to remove the operation of impurity in journey, if every procedure effectively, farthest can not remove corresponding impurity,
Then last clarity, that is, water-soluble rear clarity is that very difficult arrival requires, and wants to before the liquid upper prop after extracting therefore in industry
Do corresponding pre-treatment, prove that the extraction of this procedure deimpurity Usefulness Pair later separation has through multiple test very big
Impact, is also to ensure that the very key factor of clarity.
The method of the liquid pre-treatment after extracting in industry at present probably has following several：Ethanol extract from water precipitation, fining agent method
And supercentrifugal process.In above several method, ethanol extract from water precipitation is the most commonly used method, and its method is simple, can remove part
Oil-soluble impurities, but effect is extremely limited, if if follow-up filter plant precision is poor, can not remove excessive miscellaneous substantially
Matter, can not meet the needs of injection production substantially；Fining agent method is the more commonly used in the production of oral liquid, can remove depigmentaton etc. big
The impurity of molecule, but the process being applied to injection raw material is substantially impossible, is primarily due to fining agent composition itself and introduces
Afterwards, become impurity to be difficult to effectively remove；Supercentrifugal process, this method has to using high speed centrifuge, and rotating speed will reach 10,000
Turn/min, the impurity of part macromolecular could be removed., using being equipment limit first, input ratio is larger for this method, next to that at a high speed
During centrifugation, liquid foam is very big, brings very big inconvenience to producing, is unfavorable for that production is carried out, besides supercentrifuge
Use unreasonable in secondary operation, reason is this operation is the liquid extracting, and impurity is a lot, and composition is a lot, only leans on molecular weight
Different high-speed separation difficulty very big, separating effect is extremely limited, does not reach substantive effect.
Content of the invention
The purpose of the present invention is intended to overcome the defect of prior art, provides a kind of process is simple, low cost and can be effective
Ensure the preprocess method of the raising injection arasaponin clarity of parenteral solution clarity.
The processing method improving injection arasaponin clarity of the present invention, its process step is as follows：
A. the extract of arasaponin is adopted the method that water sinks by the Impurity removal in arasaponin, water sedimentation treatment method
For：Pseudo-ginseng ethanol extract, is concentrated to the medicinal extract of relative density 1.15-1.20, and medicinal extract is put into the cone with heating for the stirring
In shape Alcohol-settling tank, add the purified water of medicinal extract amount 4-5 times amount, stir, and heat and boil 10-30min, use recirculated water afterwards
Pressure is cooled to room temperature, this step operation can precipitate water-soluble poor starch, volatile oil, resin, fat-soluble pigment and
The impurity such as silt；
B. the Notogineng Extract of process is sunk through water, the supernatant after precipitation and separation, press 1000-3000 with link-suspended basket centrifuge
Turn/rotating speed of min filtered, the main water that removes sinks halfway impurity, mainly has silt, volatile oil, resin, fat-soluble color
The miscellaneous meal matter such as element and a little starch；
C. quartz sand column crossed by the extract after centrifuge impurity screening, removes pigment small molecular weight impurity, and its method is
（1）Quartz sand column prepares, and pillar specification is 400 × 3500, and quartz sand loading amount height is 3000, and a quartz sand column can
To process 500kg pseudo-ginseng clip extract；Using front use drinking water wash clean；
（2）Liquid after centrifuge is processed, then through quartz sand column, be former purified water water process quartz sand, flow velocity control
System is in 500-800L/h；
（3）After the excessively complete quartz sand column of liquid, with water, the liquid in quartz sand is gone out, flow control, in 500L/h, is used after going out
Pneumatics and drinking water just rinse repeatedly, and backwash carries out quartz sand is rinsed well, in case using again；
（4）Liquid entered the purpose shallow media filter of quartz sand column（Shallow medium filter）, it is to utilize stone
Ying Sha, as filter medium, under pressure, passes through water higher for turbidity the quartz of certain thickness granular or non-grain
Sand filters, and effectively retention is except the suspension in liquid, organic matter, colloidal particles, microorganism, chlorine, odor and part heavy metal
Ion etc., is finally reached reduction liquid turbidity, a kind of High-cfficiency Filtration equipment of liquid effect, is capable of the removing water-insoluble of depth
Mainly there is the miscellaneous meal matter such as silt, volatile oil, resin, fat-soluble pigment and a little starch；
D. the extract of pigment small molecular weight impurity will be removed after activated-charcoal column, remove pigment big molecular impurity；Cross stone
Sand post liquid continues through, seed activity charcoal post, and activated-charcoal column specification is 400*3500, and activated carbon loading amount height is 3000.
Liquid crosses the flow control of charcoal post in 400-600L/h.This step purpose is activated carbon filtration, active carbon filter
Work is completed by charcoal bed.The activated carbon granule of composition charcoal bed has very many micropores and huge specific surface area, tool
There is very strong physical absorption ability, carry out for larger molecular organicses, such as the carrying out of pigment is adsorbed, also adsorb simultaneously
Small organic molecule has obvious Adsorption effect to colloid, pigment, heavy metal ion etc. in liquid；
E. last, by the pre-treating method of combination of the above, the liquid of pretreatment produces injection technique by arasaponin and continues
The continuous injection arasaponin clarity down producing acquisition will be greatly improved, and can meet injection arasaponin
Material quality demand.
Described centrifuge is tripod pendulum type batch centrifugal.
Described quartz sand is Water treatment filtration quartz sand.
Described activated-charcoal column is seed activity charcoal post.
The processing method improving injection arasaponin clarity of the present invention, is through arasaponin for many years
The result of the long-term research of knowhow and laboratory, the extract of invention particularly in injection arasaponin production technology
Pre-treating method before upper prop, the method can effectively remove the big molecular impurities such as silt, pigment and the impurity such as fat-soluble mostly.With
After this method is processed, be conducive to isolating and purifying of follow-up resin, disclosure satisfy that the production needs of injection arasaponin raw material, and this
The method that invention is mainly physics, does not result in bad impact to active ingredient；In this method, water sinks and centrifugal filtration is that have
Effect removes fat-soluble impurity, and the purpose crossing quartz sand column afterwards is to ensure that removing water sinks and centrifugal filtration operation can not be complete
The method removing oil-soluble impurities, and removing unit can also divide pigment impurity.Activated-charcoal column afterwards, uses particle to live
Property charcoal post, this operation be to ensure that remove pigment macromolecular effective ways, through mistake this procedure after remaining partial pigment
Just can effective and thorough go out in the subsequent treatment of macroporous resin column.The injection pseudo-ginseng being processed by the method for the present invention
Total saposins clarity conforms to the production requirement of pharmacopeia, and process is simple effect is obvious.
The preprocess method improving injection arasaponin clarity of the present invention, is detected after process and is contrasted
Test, its result is as follows：
1st, injection arasaponin bulk drug clarity detection method：
Weigh 156 grams of arasaponins, 2000 milliliter waters for injection, after heating by electric cooker dissolving, add 24 grams of sodium chloride, add 12 afterwards
A gram activated carbon small piece of land surrounded by water is boiled 10 minutes, lets cool to 50 DEG C about, after filtering, placing to room temperature and put into 4 DEG C of refrigerator 8-12 hours, uses
The filter membrane natural filtration of 0.22um, adds 12g activated carbon and boils 10min, puts and filters to 70 DEG C about, puts and be assigned to room temperature is dilute
The membrane filtration of 0.22um, potting is used again, sterilizing, afterwards in the following time after tune pH value is to 5.8-6.0 after 3000 milliliters
Carry out clarity detection under the interior detector in lamp inspection.Detection time point is：0th, 5,10,15,20,25,30,40,50,60 days.
2nd, clarity Experimental Comparison situation
By above clarity detection method, contrast is entered through the injection arasaponin bulk drug of pretreatment and untreated production
Row clarity contrast test, result of the test is as follows：
（1）The bulk drug sample number producing through pretreatment：Y2014001、Y2014002、Y2014003、Y2014004、
Y2014005；
（2）Not pretreated bulk drug sample number：2014001、2014002、2014003、2014004、2014005；
（3）Sample treatment：
Weigh 156 grams of arasaponins, 2000 milliliter waters for injection, after heating by electric cooker dissolving, add 24 grams of sodium chloride, add 12 afterwards
A gram activated carbon small piece of land surrounded by water is boiled 10 minutes, lets cool to 50 DEG C about, after filtering, placing to room temperature and put into 4 DEG C of refrigerator 8-12 hours, uses
The filter membrane natural filtration of 0.22um, adds 12g activated carbon and boils 10min, puts and filters to 70 DEG C about, puts and be assigned to room temperature is dilute
The membrane filtration of 0.22um, potting is used again, sterilizing, afterwards in the following time after tune pH value is to 5.8-6.0 after 3000 milliliters
Carry out clarity detection under the interior detector in lamp inspection.Detection time point is：0th, 5,10,15,20,25,30,40,50,60 days.
（4）Logging and analysis
Clarity judgment rule：Ampere bottle liquid medicine after embedding visually observes under lamp inspection instrument, and limpid no opalescence is preferably
；Limpid have the less opalescence to be；Limpid have more opalescence or have a little precipitation no opalescence to be；There have to be more heavy
Form sediment and be
Test result analysis：
（1）Y2014001-05,5 samples are the injection arasaponin sample producing after pre-treatment, from result of the test
From the point of view of, clarity effectiveness comparison uniformly, all preferably, illustrates the arasaponin uniform quality that this method produces after processing, stability
Preferably
（2）2014001-05,5 samples are the arasaponin producing without pretreatment, and from the point of view of result of the test, clarity is imitated
Really uneven it was demonstrated that unstable product quality；
（3）From the point of view of result of the test, the pseudo-ginseng total soap clarity producing through pretreatment substantially produces than without pretreatment
Arasaponin clarity is well much it was demonstrated that pretreatment process has positive effect to product clarity.
Seen by above detection and comparative test result, through the Panax Notoginseng Saponins Injection clarity of pretreatment stable and
Preprocessing process science is simply although increased the cost of some pretreatments, but improves the qualification rate of product, thus reducing
The production cost of product, has saved resource, the present invention effectively overcomes the defect of prior art, so that arasaponin class is noted
Penetrate liquid energy more commonly promote significant.
Specific embodiment
With reference to embodiment, the present invention is described further, but is not limited to embodiment.
Embodiment 1
The processing method improving injection arasaponin clarity of the present invention, its process step is as follows：
A. the extract of arasaponin is adopted the method that water sinks by the Impurity removal in arasaponin, water sedimentation treatment method
For：Pseudo-ginseng ethanol extract, is concentrated to the medicinal extract of relative density 1.15-1.20, and medicinal extract is put into the cone with heating for the stirring
In shape Alcohol-settling tank, add the purified water of medicinal extract amount 4-5 times amount, stir, and heat and boil 10-30min, use recirculated water afterwards
Pressure is cooled to room temperature, this step operation can precipitate water-soluble poor starch, volatile oil, resin, fat-soluble pigment and
The impurity such as silt；
B. the Notogineng Extract of process is sunk through water, the supernatant after precipitation and separation, turn/min with centrifuge by 1000-3000
Rotating speed filtered, the main water that removes sinks halfway impurity, mainly have silt, volatile oil, resin, fat-soluble pigment and
The miscellaneous meal matter such as a little starch；
C. quartz sand column crossed by the extract after centrifuge impurity screening, removes pigment small molecular weight impurity, and its method is：
（1）Quartz sand column prepares, and pillar specification is 400 × 3500, and quartz sand loading amount height is 3000, and a quartz sand column can
To process 500kg pseudo-ginseng clip extract；Using front use drinking water wash clean；
（2）Liquid after centrifuge is processed, then through quartz sand column, be former purified water water process quartz sand, flow velocity control
System is in 500-800L/h；
（3）After the excessively complete quartz sand column of liquid, with water, the liquid in quartz sand is gone out, flow control, in 500L/h, is used after going out
Pneumatics and drinking water just rinse repeatedly, and backwash carries out quartz sand is rinsed well, in case using again；
（4）Liquid entered the purpose shallow media filter of quartz sand column（Shallow medium filter）, it is to utilize stone
Ying Sha, as filter medium, under pressure, passes through water higher for turbidity the quartz of certain thickness granular or non-grain
Sand filters, and effectively retention is except the suspension in liquid, organic matter, colloidal particles, microorganism, chlorine, odor and part heavy metal
Ion etc., is finally reached reduction liquid turbidity, a kind of High-cfficiency Filtration equipment of liquid effect, is capable of the removing water-insoluble of depth
Mainly there is the miscellaneous meal matter such as silt, volatile oil, resin, fat-soluble pigment and a little starch；
D. the extract of pigment small molecular weight impurity will be removed after activated-charcoal column, remove pigment big molecular impurity；Cross stone
Sand post liquid continues through, seed activity charcoal post, and activated-charcoal column specification is 400*3500, and activated carbon loading amount height is 3000.
Liquid crosses the flow control of charcoal post in 400-600L/h.This step purpose is activated carbon filtration, active carbon filter
Work is completed by charcoal bed.The activated carbon granule of composition charcoal bed has very many micropores and huge specific surface area, tool
There is very strong physical absorption ability, carry out for larger molecular organicses, such as the carrying out of pigment is adsorbed, also adsorb simultaneously
Small organic molecule has obvious Adsorption effect to colloid, pigment, heavy metal ion etc. in liquid；
E. last, by the pre-treating method of combination of the above, the liquid of pretreatment produces injection technique by arasaponin and continues
The continuous injection arasaponin clarity down producing acquisition will be greatly improved, and can meet injection arasaponin
Material quality demand.
Embodiment 2
The processing method improving injection arasaponin clarity of the present invention, its process step is as follows：
A. the extract of arasaponin is adopted the method that water sinks by the Impurity removal in arasaponin, water sedimentation treatment method
For：Pseudo-ginseng ethanol extract, is concentrated to the medicinal extract of relative density 1.15-1.20, and medicinal extract is put into the cone with heating for the stirring
In shape Alcohol-settling tank, add the purified water of medicinal extract amount 4-5 times amount, stir, and heat and boil 10-30min, use recirculated water afterwards
Pressure is cooled to room temperature, this step operation can precipitate water-soluble poor starch, volatile oil, resin, fat-soluble pigment and
The impurity such as silt；
B. the Notogineng Extract of process is sunk through water, the supernatant after precipitation and separation, press 1000-3000 with link-suspended basket centrifuge
Turn/rotating speed of min filtered, the main water that removes sinks halfway impurity, mainly has silt, volatile oil, resin, fat-soluble color
The miscellaneous meal matter such as element and a little starch；
C. quartz sand column crossed by the extract after centrifuge impurity screening, removes pigment small molecular weight impurity, and its method is
（1）Quartz sand column prepares, and pillar specification is 400 × 3500, and quartz sand loading amount height is 3000, and a quartz sand column can
To process 500kg pseudo-ginseng clip extract；Using front use drinking water wash clean；
（2）Liquid after centrifuge is processed, then through quartz sand column, be former purified water water process quartz sand, flow velocity control
System is in 500-800L/h；
（3）After the excessively complete quartz sand column of liquid, with water, the liquid in quartz sand is gone out, flow control, in 500L/h, is used after going out
Pneumatics and drinking water just rinse repeatedly, and backwash carries out quartz sand is rinsed well, in case using again；
（4）Liquid entered the purpose shallow media filter of quartz sand column（Shallow medium filter）, it is to utilize stone
Ying Sha, as filter medium, under pressure, passes through water higher for turbidity the quartz of certain thickness granular or non-grain
Sand filters, and effectively retention is except the suspension in liquid, organic matter, colloidal particles, microorganism, chlorine, odor and part heavy metal
Ion etc., is finally reached reduction liquid turbidity, a kind of High-cfficiency Filtration equipment of liquid effect, is capable of the removing water-insoluble of depth
Mainly there is the miscellaneous meal matter such as silt, volatile oil, resin, fat-soluble pigment and a little starch；
D. the extract of pigment small molecular weight impurity will be removed after seed activity charcoal post, remove pigment big molecular impurity；Cross
Complete quartz sand column liquid continues through, seed activity charcoal post, and activated-charcoal column specification is 400*3500, and activated carbon loading amount height is
3000.Liquid crosses the flow control of charcoal post in 400-600L/h.This step purpose is activated carbon filtration, and activated carbon filters
The work of device is completed by charcoal bed.The activated carbon granule of composition charcoal bed has very many micropores and huge specific surface
Long-pending, there is very strong physical absorption ability, carry out for larger molecular organicses, such as the carrying out of pigment is adsorbed, simultaneously
Also absorption small organic molecule has obvious Adsorption effect to colloid, pigment, heavy metal ion etc. in liquid；
E. last, by the pre-treating method of combination of the above, the liquid of pretreatment produces injection technique by arasaponin and continues
The continuous injection arasaponin clarity down producing acquisition will be greatly improved, and can meet injection arasaponin
Material quality demand.
Claims (5)
1. a kind of preprocess method improving injection arasaponin clarity is it is characterised in that its process step is as follows：
A. the extract of arasaponin is adopted the method that water sinks by the Impurity removal in arasaponin, water sedimentation treatment method
For：Pseudo-ginseng ethanol extract, is concentrated to the medicinal extract of relative density 1.15-1.20, and medicinal extract is put into the cone with heating for the stirring
In shape Alcohol-settling tank, add the purified water of medicinal extract amount 4-5 times amount, stir, and heat and boil 10-30min, use recirculated water afterwards
Pressure is cooled to room temperature, this step operation can precipitate water-soluble poor starch, volatile oil, resin, fat-soluble pigment and
The impurity such as silt；
B. the Notogineng Extract of process is sunk through water, the supernatant after precipitation and separation, turned by 1000-3000 with centrifuge/min
Rotating speed is filtered, and the main water that removes sinks halfway impurity, mainly has silt, volatile oil, resin, fat-soluble pigment and few
Permitted the miscellaneous meal matter such as starch；
C. quartz sand column crossed by the extract after centrifuge impurity screening, removes pigment small molecular weight impurity, and its method is
（1）Quartz sand column prepares, and pillar specification is 400 × 3500, and quartz sand loading amount height is 3000, and a quartz sand column can
To process 500kg pseudo-ginseng clip extract；Using front use drinking water wash clean；
（2）Liquid after centrifuge is processed, then through quartz sand column, flow control is in 500-800L/h；
（3）After the excessively complete quartz sand column of liquid, with water, the liquid in quartz sand is gone out, flow control, in 500L/h, is used after going out
Pneumatics and drinking water just rinse repeatedly, and backwash carries out quartz sand is rinsed well, in case using again；
（4）Liquid entered the purpose shallow media filter of quartz sand column（Shallow medium filter）, it is to utilize stone
Ying Sha, as filter medium, under pressure, passes through water higher for turbidity the quartz of certain thickness granular or non-grain
Sand filters, and effectively retention is except the suspension in liquid, organic matter, colloidal particles, microorganism, chlorine, odor and part heavy metal
Ion etc., is finally reached reduction liquid turbidity, a kind of High-cfficiency Filtration equipment of liquid effect, is capable of the removing water-insoluble of depth
Mainly there is the miscellaneous meal matter such as silt, volatile oil, resin, fat-soluble pigment and a little starch；
D. the extract of pigment small molecular weight impurity will be removed after activated-charcoal column, remove pigment big molecular impurity；Cross stone
Sand post liquid continues through, seed activity charcoal post, and activated-charcoal column specification is 400*3500, and activated carbon loading amount height is 3000,
Liquid crosses the flow control of charcoal post in 400-600L/h；
E. last, by the pre-treating method of combination of the above, the liquid of pretreatment produces injection technique by arasaponin and continues
The continuous injection arasaponin clarity down producing acquisition will be greatly improved, and can meet injection arasaponin
Material quality demand.
2. a kind of preprocess method improving injection arasaponin clarity according to claim 1, its feature exists
In described centrifuge is tripod pendulum type batch centrifugal.
3. a kind of preprocess method improving injection arasaponin clarity according to claim 1, its feature exists
In described quartz sand is Water treatment filtration quartz sand.
4. a kind of preprocess method improving injection arasaponin clarity according to claim 1, its feature exists
In being former purified water water process quartz sand.
5. a kind of preprocess method improving injection arasaponin clarity according to claim 1, its feature exists
In described activated-charcoal column is seed activity charcoal post.
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| CN107519128A (en) * | 2017-08-30 | 2017-12-29 | 芜湖杨燕制药有限公司 | A kind of filter method of traditional Chinese medicine production |
| CN115448970A (en) * | 2022-11-14 | 2022-12-09 | 云南白药集团中药资源有限公司 | Separation and purification method of panax notoginseng saponins |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519128A (en) * | 2017-08-30 | 2017-12-29 | 芜湖杨燕制药有限公司 | A kind of filter method of traditional Chinese medicine production |
| CN115448970A (en) * | 2022-11-14 | 2022-12-09 | 云南白药集团中药资源有限公司 | Separation and purification method of panax notoginseng saponins |
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