CN106420780A - Traditional Chinese medicine dropping pill and preparation method thereof - Google Patents
Traditional Chinese medicine dropping pill and preparation method thereof Download PDFInfo
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- CN106420780A CN106420780A CN201610847219.4A CN201610847219A CN106420780A CN 106420780 A CN106420780 A CN 106420780A CN 201610847219 A CN201610847219 A CN 201610847219A CN 106420780 A CN106420780 A CN 106420780A
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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Abstract
The invention discloses a traditional Chinese medicine dropping pill having the functions of clearing away heat and toxic materials, releasing orifices and activating collaterals. The traditional Chinese medicine dropping pill is characterized by being prepared by adopting a method including the following steps that, by weight, 3-7 parts of geniposide extract, 8-15 parts of baicalin extract and 12-18 parts of borneol are prepared; medicinal raw material powder and a matrix are weighed according to the weight part proportion of 1 to 0.8-1.5, the matrix is prepared from PEG6000 and PEG4000 with the ratio of 1 to 1.8-2.5, heating is performed to 75-90 DEG C, and the dropping pill is prepared under the condition of the dropping speed of 30-50 drops/min. The traditional Chinese medicine dropping pill has the effects of clearing away heat and toxic materials, releasing orifices and activating collaterals and is suitable for acute-stage and early-convalescence upward disturbance syndromes about blood stasis obstructing the collaterals and wind-fire of apoplexy involving both collateral and meridian in stroke diseases.
Description
Technical field
The present invention relates to a kind of Chinese medicine dripping pills and preparation method thereof and in particular to a kind of Chinese medicine dripping pills of drop pill of the present invention and
Its preparation method.
Background technology
Fructus Gardeniae is the fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis, is Chinese medicine, genus is defended
First medicine-food two-purpose resource that life portion promulgates, Fructus Gardeniae has purging intense heat relieving restlessness, removing pathogenic heat from blood and toxic substance from the body, and effect of eliminating damp-heat, for heat
Disturb the mind, pharyngeal swelling conjunctival congestion, pathopyretic ulcer, susceptible to lose temper due to restlessness, the same bitter taste of rib, damp invasion of lower energizer, the disease such as puckery pain of heat gonorrhea.Radix Scutellariae is Labiatae
The root of the Radix Scutellariae Scutellaria baicalensis Georgi of Scutellaria, bitter in the mouth, cold in nature, having can heat clearing and damp drying, pathogenic fire purging
Removing toxic substances, hemostasis, antiabortive the effects such as.Cure mainly epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, cough
The diseases such as blood, conjunctival congestion, frequent fetal movement, hypertension, carbuncle swells furuncle sore.
Chemical composition and Effect study show：Scutellariae,radix contain flavone compound baicalin, baicalin, wogonoside,
Wogonin, neobaicalein I, neobaicalein II etc., Radix Scutellariae has antioxidation, antibacterium, antiviral, antifungic action, resists swollen
Tumor, antiinflammatory refrigeration function, antiallergic action, atherosclerosis, blood pressure lowering etc. act on, additionally, Radix Scutellariae and effective ingredient are protected
Liver and radioprotective, platelet aggregation that anticoagulant, enzyme caused etc. acts on.Contain iridoid constituents in Fructus Gardeniae, have Fructus Gardeniae
Glycosides, geniposide (geniposide) and its hydrolyzate genipin etc., additionally, also contain cupreol, saffron glucoside, Fructus Gardeniae
The compositions such as element, crocin and ursolic acid, Fructus Gardeniae has good hepatoprotective, promotes bile secretion, protection pancreatic cell, adjusts stomach
Function, protection cerebral tissue, blood pressure lowering, blood circulation promoting, antipyretic calmness, antimicrobial antiphlogistic, antitumor, antiallergic, reparation soft tissue
The effect damaging.Clinically it is used for treating acute icterohepatitises, bruise.
Ischemic cerebrovascular is to threaten one of principal disease of human health and existence, has high incidence, high illness
Rate, high mortality, the feature of high disability rate.In recent years, with the continuous development of Pharmacokinetics research, more and more
Research worker starts by advanced instrument equipment, using principle of dynamics, using the quantitative announcement medicine of mathematical model in body
Interior dynamic changing process.
Content of the invention
Present invention aim at offer is a kind of has heat-clearing and toxic substances removing, the Chinese medicine dripping pills of the active function of inducing resuscitation and its preparation side
Method.
The present invention seeks to be achieved through the following technical solutions：
Crude drug consists of：Fructus Gardeniae glucoside extract 3-7 weight portion, Radix Scutellariae glucoside extract 8-15 weight portion, Borneolum Syntheticum 12-18 weight
Amount part；
Preparation：Weighing weight is 1:The crude drug medicated powder of 0.8-1.5 and substrate, substrate is 1:1.8-2.5
PEG6000 and PEG4000, is heated to 75-90 DEG C, drip a fast 30-50 drip/min under the conditions of make drop pill.
Crude drug composition is preferably：
Fructus Gardeniae glucoside extract 5.4 weight portion, Fructus Gardeniae glucoside extract 12.6 weight portion, Borneolum Syntheticum 15 weight portion；
Fructus Gardeniae glucoside extract 4 weight portion, Radix Scutellariae glucoside extract 13 weight portion, Borneolum Syntheticum 13 weight portion；
Fructus Gardeniae glucoside extract 6 weight portion, Radix Scutellariae glucoside extract 10 weight portion, Borneolum Syntheticum 16 weight portion；
Preferably wherein, medicated powder and substrate composition are 1:1, substrate is 1:2 PEG6000, PEG4000, is heated to 80 DEG C,
Drop pill is made under the conditions of dripping fast 40/min.
Brief description
Fig. 1 A high-efficient liquid phase chromatogram
Fig. 2 B high-efficient liquid phase chromatogram
Fig. 3 C high-efficient liquid phase chromatogram
Fig. 4 D high-efficient liquid phase chromatogram
Fig. 5 E high-efficient liquid phase chromatogram, A. jasminoidin reference substance；B. Fructus Gardeniae extract；C. baicalin reference substance；D. Radix Scutellariae
Extract；E drop pill of the present invention
Fig. 6 jasminoidin canonical plotting
Fig. 7 baicalin canonical plotting
Fructus Gardeniae glucoside extract of the present invention, Fructus Gardeniae glucoside extract are obtained by the preparation method going out given in prior art
Arrive.Drop pill of the present invention has the active work(of heat-clearing and toxic substances removing, inducing resuscitation it is adaptable to apoplexy apoplexes involving the channels and collaterals acute stage and the stasis of blood recovering early stage
Blood hinders complexation wind-fire upper harassing syndrome.Compared with other treatment apoplexy medicine, drop pill of the present invention has the traditional Chinese medical science " heat clearing away in terms of prescription
Removing toxic substances, inducing resuscitation active " unique treatment rule；In terms of disease, its treated cerebral infarction apoplex involving the channels and collaterals, obstruction of collaterals by blood stasis close wind
Fiery upper harassing syndrome acute stage and recovery early stage are badly in need of by clinic；In terms of medicament, it adopts the preparation method of five kind new medicines, in being
Medicine effective site (composition) drop pill, has safe and effective, stable and controllable for quality, oral quick-acting advantage and characteristic.
Experimental example 1 study of pharmacy is tested
1. instrument and reagent
1.1 instrument
Waters 2695 high performance liquid chromatograph, (U.S. Waters is public to join Waters2996 diode array detector
Department)；Electric heating constant-temperature blowing drying box DHG-9140 type (upper Nereid's grand experimental facilitiess company limited)；CQ250 ultrasonic cleaner
(Kunshan He Chuan ultrasonic instrument company limited)；BT-25S type electronic balance (Beijing Sai Duolisi instrument system company limited),
MP5002 electronic balance (Shanghai Hengping Science Instrument Co., Ltd.)；Intelligent disintegration tester (Tian Jing Tianda Tianfa Science and Technology Co. Ltd.)
DWJ-2000S-D type drop pill testing machine (Yantai 100 Chinese Medicine Tai Technology Development Limited)；(Shanghai is accurate for PHS-3C PH meter
Scientific instrument company limited)
1.2 reagent
Fructus Gardeniae glucoside extract (Nanjing Ze Lang Zhi Ti company, lot number：20130411), (Nanjing Ze Lang plants Radix Scutellariae glucoside extract
Carry company, lot number：20130322), Borneolum Syntheticum (Xi'an Sheng Xing prepared slices of Chinese crude drugs company).Reference substance jasminoidin (the biological system of Chinese medicine
Institute, lot number are determined in product examine：110749-201115)；Reference substance baicalin (Nat'l Pharmaceutical ＆ Biological Products Control Institute, lot number：715-
200111).Acetonitrile is chromatographically pure, and water is Wahaha Pure Water, and it is pure that remaining reagent is analysis.
2. experimental technique and result
Orthogonal (Orthogonal) test of 2.1 dropping pill techniques of the present invention
2.1.1 Orthogonal EXPERIMENTAL DESIGN
To the principal element medicated powder substrate ratio of impact dropping pill technique, PEG6000：PEG4000 ratio, feed temperature, medicinal liquid
Temperature carries out the Orthogonal Experiment and Design of 4 factor 3 level, and factor level is shown in Table 1.
Table 1 Orthogonal experimental factor water-glass
Tab.1 Factors and levels of orthogonal test
2.1.2 the preparation of drop pill of the present invention
Weigh Fructus Gardeniae glucoside extract 5.4g respectively, Radix Scutellariae glucoside extract 12.6g, Borneolum Syntheticum 15g, by orthogonal condition
1-9 drop pill sample of preparation, dries, and 24h is dried at 25 DEG C of room temperature, pulverizes powder in (60 mesh) one-tenth, standby.
2.2 Fructus Gardeniae by HPLC glycosides, content of baicalin
2.2.1 chromatograph chromatographic condition and system suitability test
Chromatographic column Thermo (250mm × 4.6mm, 5um), mobile phase：Methanol -0.1% phosphoric acid solution (35:65), detect
Wavelength:210-400nm, column temperature:30 DEG C, theoretical cam curve is calculated by jasminoidin peak and is not less than 5000, using isocratic condition
Eluting.Chromatogram is shown in Fig. 1,2,3,4,5
2.2.2 have specifying of peak
In conjunction with the relevant parameter of the HPLC collection of illustrative plates of 18 groups of drop pill samples, HPLC chromatogram in figure is selected to can be used for reflecting the present invention
The total peak of drop pill effect is being measured, and the jasminoidin finally determining under 238nm specific wavelength has peak and is 1 altogether,
Baicalin under 280nm specific wavelength has peak and is 1 altogether.See Fig. 5
2.3 methodological study
2.3.1 the preparation of reference substance solution
Take jasminoidin reference substance, baicalin reference substance appropriate, accurately weighed, plus methanol is respectively prepared every 1mL and contains jasminoidin
92 μ g, the solution of baicalin 125 μ g, obtain final product.
2.3.2 the preparation of need testing solution
Take under 9 groups of experiment items powder in drop pill respectively, (every group parallel sample preparation 2 parts) is accurately weighed, and each group sampling amount see table,
Put respectively in 25ml volumetric flask, plus methanol 10ml, ultrasonic 30min, take out afterwards, plus methanol, to scale, shakes up, and obtains final product.
Take Fructus Gardeniae glucoside extract respectively, Radix Scutellariae glucoside extract, accurately weighed, put respectively in 25ml volumetric flask, plus methanol
10ml, ultrasonic 30min, take out afterwards, plus methanol, to scale, shakes up, and obtains final product.
2.3.3 the drafting of standard curve
Accurate draw jasminoidin reference substance solution (concentration is：92 μ g/mL) 2,4,6,8,10 μ L, by above-mentioned chromatographic condition note
Enter chromatograph, measure its peak area, with peak area A as vertical coordinate, sample size (μ g) draws standard curve for abscissa.Calculate
Jasminoidin regression equation is A=172690C+1213.8, correlation coefficient r=0.9999.Result shows jasminoidin mark product 0.184
Good with peak area linear relationship in～0.920 μ g range.The results are shown in Table 6, Fig. 6.
Precision takes baicalin reference substance solution 2,4,5,6,8,10,12,14,16 μ L, measures its peak area, calculates Radix Scutellariae
Glycosides linear equation is A=522169C-166421, r=0.9997, and result shows baicalin mark product in 0.25～2.00 μ g range
Interior and peak area assumes good linear relationship.The results are shown in Table 7, Fig. 7.
Table 6 jasminoidin standard curve test data
Tab.6 Standard curve of geniposid
Table 7 baicalin standard curve data
Tab.7 Standard curve of baicalin
2.3.4 precision test
Take same need testing solution (1-1) continuous sample introduction 6 times in 2.3.2 test liquid, measure peak area, calculate RSD.Result
It is shown in Table 6.
Table 8 Precision test result
Tab.8 Results of precision test
Result shows, the precision of this instrument is good.
2.3.5 stability test
Choose same sample group (1-1) in 2.3.2 test liquid and be respectively separated 0, after 4,8,12,24h, sample introduction measures, and result is shown in
Table 7.
Table 9 stability test result
Tab.9 Results of stsbility test
Result RSD is respectively 0.66%, and 0.74% shows that test sample is stable in 24h, and measurement result is credible.
2.3.6 reappearance test
Choose same batch test sample, make 5 samples altogether according to test sample preparation method, respectively sample introduction measure and calculation, knot
Fruit is shown in Table 10.
Table 10 reproducible test results
Tab.10 Results of repetition test
Result RSD is 1.00%, and 1.85% shows that repeatability is good.
2.4 data analysiss and preparation technology parameter optimization
2.4.1 achievement data standardization
Select PEG4000 and PEG6000 as substrate, by measuring pill weight variation, leaching time limit and particle diameter objective indicator
Thus evaluating the quality of drop pill.Using L9(34) Orthogonal Experiment and Design, preferably optimal moulding process, using jasminoidin and baicalin
Content and HPLC finger printing evaluate optimizing technology parameters.
Table 11 drop pill sample indicator-specific statisticss table
Tab.11 index dropping sample statistics
Table 12 baicalin collection of illustrative plates peak area counts
Tab.12 Area of characteristic peaks in HPLC baicalin of different
steaming processing smple
Table 13 jasminoidin collection of illustrative plates peak area counts
Tab.13 Area of characteristic peaks in HPLC jasminoidin of different
steaming processing smple
Table 14 drop pill of the present invention analytical table directly perceived
Tab.14 dropping pill qing xuan qiao brain intuitive analysis table
Note：Using " leaching the time " and " pill weight variation " objective indicator comprehensive grading, comprehensive grading=(leach time/
Leach greatly the time) × 100 × 0.4+ (pill weight variation/maximum pill weight variation) × 100 × 0.3+ (jasminoidin rate of transform+baicalin
The rate of transform)/2/ maximum transfer rate × 100 × 0.3.
Table 15 drop pill analysis of variance table of the present invention
Tab.15 clear brain xuan qiao dropping variance analysis table
2.4.2 data analysiss
By the results of analysis of variance, the extreme difference value of relatively each factor can be seen that the factor order of impact drop pill molding for carrying
Take thing：Substrate>Fluid temperature>PEG6000：PEG4000>Drip speed, can be drawn by analysis directly perceived, determine dropping pill formulation molding work
Skill condition is A1B1C3D2.I.e. extract and substrate ratio are 1:1, PEG6000：PEG4000 is 1:2, feed temperature is 80 DEG C, drips
Speed is 40/min.
2.4.3 checking test
Weighing medicated powder with substrate composition is 1:1, it is heated to 80 DEG C, the ratio of weighing is 1:2 PEG6000, PEG4000,
Prepare drop pill under the conditions of dripping fast 40/min, for checking the reliability of experimental result, the present invention is carried out using above-mentioned technological parameter
Dropping pill technique test carries out 3 parallel tests, and randomly drawing sample is investigated, and the RSD of result pill weight variation is 0.56%, puts down
All leach the time 6.5 minutes, drop pill presentation quality is good, ball shape is complete, and color and luster is homogeneous, preferably, result shows that this technique is steady to hardness
Fixed feasible.
Experimental example 2 pharmacodynamic experiment
1. material and method
Microscope Olympus BX51 just put by 1.1 instruments, medicine and reagent；Ophthalmologic operation is cut；Ophthalmic forceps；Water-bath
Pot：Ke Wei Yongxing, Beijing Instrument Ltd. model HH-1 type；Electronic balance：The limited public affairs of Sai Duolisi scientific instrument (Beijing)
Department, capital system 00000246.Drop pill (according to the preparation of embodiment 1 method) of the present invention；Xuesaitong dispersible tablet, YUNNAN BAIYAO group is big
Reason Pharmaceutical Co., Ltd produces, lot number：Chinese medicines quasi-word Z20050467；Penicillin：HARBIN PHARMACEUTICAL GROUP CO., LTD. General Pharm. Factory, traditional Chinese medicines are accurate
Word：H23021439；Red tetrazolium (TTC) is purchased from Sigma Co., USA；Chloral hydrate：Upper seamount Pu Chemical Co., Ltd., batch
Number：20110209.
1.2 laboratory animals, packet administration and modeling SD rat, male and female half and half, body weight 180～200g, Xi'an Communications University
Medical college animal experimental center provides, credit number:0011740.Experiment prospective adaptation raises 3d, is randomly divided into 5 groups, that is, does evil through another person
Art group, cerebral ischemic model group, drop pill 0.9g/kg group of the present invention, drop pill 1.8g/kg group of the present invention, XUESAITONG 0.3g/kg group.Give
Medicine group gavages large and small dosage drop pill of the present invention (18 times, 9 times of suitable people's consumption respectively) respectively, and XUESAITONG 30mg/kg is (quite
6 times of people's consumption), model group gavages same volume normal saline, is administered once daily.1h after 10d administration, 10% hydration chlorine
Aldehyde 0.35ml/100g intraperitoneal injection of anesthesia, makees cervical region median incision, and blunt separation bilateral common carotid arteries simultaneously ligature, 24h after modeling
It is administered once again.
1.3 nervous symptoms scorings are improved according to 5 grades of point systems of Zea Longa, are evaluated in postoperative 24h, stupor
Person rejects.Standards of grading：No obvious nervous symptoms, 0 point；It is unable to fore paw on the left of full extension, 1 point；Rotate to the left, 2 points；OK
Topple over to the left when walking, 3 points；Can not voluntarily walk, 4 points.
Beam test is the coordination of hind limb motor and the defect of integration ability is estimated.Experiment beam (long 120cm, wide
2.0cm, thick 1cm) vacantly to place away from ground 80cm level, one end connects a magazine (long 25cm, wide 22cm, high 18cm), uses noise
Stimulation in rats comes into magazine by beam.Standards of grading:Rat can not stay on beam, 0 point；Rat can stay on beam but not
Dynamic, 1 point；Rat attempts to pass through, but throws from beam, 2 points；Rat walks upper cord, but hind leg landing number of times is more than 50%, 3 point；
Hind leg landing is more than 1 time but less than 50%, 4 point；Only landing 1 time, 5 points；Pass through, 6 points.Preoperative exercise 3d, allows rat
Can smoothly pass by beam.
1.4 cerebral infarct sizes postoperative 24h animal deep anaesthesia, broken end takes brain, cerebral tissue is placed in 0 DEG C of ice physiology salt
10min in water, makees coronal section every 2mm backward by front pole, is placed in the 0.2%TTC solution having configured, 37 DEG C of incubations
30min, normal structure dyes redness, infarction tissue's white colouring.After dyeing, 10% formalin fixes 24h, by white tissues
Carefully dig down and weigh, the percentage ratio of full brain weight and Ipsilateral brain weight is accounted for as Range of Cerebral Infarction (%) using blocking tissue's weight.
Calculate infarct volume percentage ratio.
1.5 brain water contents measure the quick broken end of postoperative 24h and take brain, remove olfactory bulb, brain stem and cerebellum, blot table with filter paper
Face moisture, weighs left and right cutaneous horn weight respectively.It is placed in baking oven, to constant weight, accurate weighing dry weight, calculating contains 105 DEG C of baking 48h again
The water yield.Brain water content=[(weight in wet base-dry weight)/weight in wet base] * 100%.
1.6 rat cortical tissue pathomorphisms check in postoperative 24h, and every group takes 3 rats, at random through lumbar injection 10%
Chloral hydrate anesthesia (0.35ml/100g body weight), broken end takes brain, and 10% formalin is fixed, and draws materials, and routinely makes section,
With resinenes sealing, in Olympus optical microphotograph Microscopic observation HE stained, LEICA digital micro-analysis photographing unit collection figure
Picture, respectively chooses 2 visuals field in each group animal ischemia side (right side) cortical sites, takes pictures and carry out morphological observation.
1.7 statistical method numerical value all adoptRepresent, carry out data system with SPSS 19.0for windows
Meter analysis, compares between group using ANOVA analysis.
2. result
2.1 neurological deficit score and beam walking test result show, after ischemia 2h fills 22h again, rat occurs to a certain degree
Neurologic impairment symptom, show as forelimb flexing, drop in resistance when side promotes, forelimb muscular tension declines and does not stop to side
Turn-take, neurological deficit score is significantly raised, compared with sham operated rats, there were significant differences (P<0.01)；Compare with model group, the present invention
Drop pill small dose group and XUESAITONG group neurologic defect symptom are also improved in varying degrees, and have statistical significance (P<0.05).Knot
Fruit is shown in Table 16.
2.2 infarct size rating model group infarct percent are maximum, compare with each administration group, and remaining each administration group blocks face
Amass and all assume certain downward trend, show that institute's drug all has certain therapeutical effect to cerebral ischemic model.It is shown in Table 2.
2.3 Brain edema rates are compared with sham operated rats, and about model group and each administration group, brain water content all has certain rising, table
Bright cerebral ischemia operation produces certain cerebral edema effect to the rat of model.It is shown in Table 17.
The impact to rat cerebral ischemia model brain injury neurological deficit score for table 16 drop pill of the present invention
Note：Compare with model group, * * p<0.01,*p<0.05
The impact to rat cerebral ischemia model brain injury brain infarction area and brain water content for table 17 drop pill of the present invention
Note：Compare with model group, * * * p<0.01
2.4 pathological observation sham operated rats visible local Mild edema, remaining has no obvious pathological change.Model group is visible
Brain tissue cell edema, vasogenic edema, partially visible microglia hypertrophy, become abortive haul shape it is seen that on a small quantity necrosis.Greatly
Dosage group visible cerebral tissue mild hepatocellular edema, vasogenic edema, microglia hypertrophy.Small dose group cerebral tissue is visible
Edema, partially visible one-tenth abortive haul shape it is seen that small area is downright bad, subregion visible microglia hypertrophy.XUESAITONG local can
Water breakthrough swells, microglia hypertrophy.
The various complexity of damage mechanisms after ischemic encephalopathy morbidity, mainly includes inflammatory reaction, intracellular calcium overload, cell toxicant
Property effect, oxidative stress etc..It can be seen that comparing each administration group brain injury all have certain mitigation with model group, show that the present invention is dripped
Ball can improve rat cerebral ischemia, and the result of behavioristicss and infarct size and Brain edema rate also indicates that in the protection of ischemic brain brain
There is also certain trend.
Embodiment 1：
Fructus Gardeniae glucoside extract 5.4kg, Radix Scutellariae glucoside extract 12.6kg, Borneolum Syntheticum 15kg
Embodiment 2：
Fructus Gardeniae glucoside extract 4kg, Radix Scutellariae glucoside extract 13kg, Borneolum Syntheticum 13kg；
Weighing weight is 1:0.8 crude drug medicated powder and substrate, substrate is 1:2.5 PEG6000 and
PEG4000, is heated to 75 DEG C, makes drop pill under the conditions of dripping fast 50/min.
Embodiment 3：
Fructus Gardeniae glucoside extract 6kg, Radix Scutellariae glucoside extract 10kg, Borneolum Syntheticum 16kg；
Weighing weight is 1:1.5 crude drug medicated powder and substrate, substrate is 1:1.8 PEG6000 and
PEG4000, is heated to 90 DEG C, makes drop pill under the conditions of dripping fast 30/min.
Claims (10)
1. a kind of Chinese medicine dripping pills with heat-clearing and toxic substances removing, the active function of inducing resuscitation are it is characterised in that this drop pill is to make by the following method
Become：
Crude drug consists of：Fructus Gardeniae glucoside extract 3-7 weight portion, Radix Scutellariae glucoside extract 8-15 weight portion, Borneolum Syntheticum 12-18 weight
Part；
Preparation：Weighing weight is 1:The crude drug medicated powder of 0.8-1.5 and substrate, substrate is 1:The PEG6000 of 1.8-2.5
And PEG4000, be heated to 75-90 DEG C, drip a fast 30-50 drip/min under the conditions of make drop pill.
2. as claimed in claim 1 a kind of Chinese medicine dripping pills it is characterised in that this drop pill is made by the following method：Its Central Plains
Material medicine consists of,
Fructus Gardeniae glucoside extract 5.4 weight portion, Radix Scutellariae glucoside extract 12.6 weight portion, Borneolum Syntheticum 15 weight portion；
Fructus Gardeniae glucoside extract 4 weight portion, Radix Scutellariae glucoside extract 13 weight portion, Borneolum Syntheticum 13 weight portion；
Or Fructus Gardeniae glucoside extract 6 weight portion, Radix Scutellariae glucoside extract 10 weight portion, Borneolum Syntheticum 16 weight portion.
3. described a kind of Chinese medicine dripping pills as arbitrary in claim 1-2 are it is characterised in that this drop pill is made by the following method：
Wherein, medicated powder and substrate composition are 1:1.
4. described a kind of Chinese medicine dripping pills as arbitrary in claim 1-2 are it is characterised in that this drop pill is made by the following method：
Wherein, substrate is 1:2 PEG6000, PEG4000.
5. described a kind of Chinese medicine dripping pills as arbitrary in claim 1-2 are it is characterised in that this drop pill is made by the following method：
Wherein, it is heated to 80 DEG C, drip fast 40/min.
6. a kind of have heat-clearing and toxic substances removing, the preparation method of the Chinese medicine dripping pills of the active function of inducing resuscitation it is characterised in that the method is：
Crude drug consists of：Fructus Gardeniae glucoside extract 3-7 weight portion, Radix Scutellariae glucoside extract 8-15 weight portion, Borneolum Syntheticum 12-18 weight
Part；
Preparation：Weighing weight is 1:The crude drug medicated powder of 0.8-1.5 and substrate, substrate is 1:The PEG6000 of 1.8-2.5
And PEG4000, be heated to 75-90 DEG C, drip a fast 30-50 drip/min under the conditions of make drop pill.
7. as claimed in claim 6 a kind of preparation method of Chinese medicine dripping pills it is characterised in that the method
Middle crude drug consists of,
Fructus Gardeniae glucoside extract 5.4 weight portion, Radix Scutellariae glucoside extract 12.6 weight portion, Borneolum Syntheticum 15 weight portion；
Fructus Gardeniae glucoside extract 4 weight portion, Radix Scutellariae glucoside extract 13 weight portion, Borneolum Syntheticum 13 weight portion；
Or Fructus Gardeniae glucoside extract 6 weight portion, Radix Scutellariae glucoside extract 10 weight portion, Borneolum Syntheticum 16 weight portion.
8. described a kind of preparation method of Chinese medicine dripping pills as arbitrary in claim 6-7 it is characterised in that the method Chinese medicine powder with
Substrate composition is 1:1.
9. described a kind of preparation method of Chinese medicine dripping pills as arbitrary in claim 6-7 is it is characterised in that the method mesostroma is
1:2 PEG6000, PEG4000.
10. the preparation method of a kind of Chinese medicine dripping pills as described in described a kind of Chinese medicine dripping pills as arbitrary in claim 6-7, its feature
It is that in the method, heating-up temperature is 80 DEG C, dripping speed is 40/min.
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| CN201610847219.4A CN106420780A (en) | 2016-09-24 | 2016-09-24 | Traditional Chinese medicine dropping pill and preparation method thereof |
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| CN108782900A (en) * | 2018-08-09 | 2018-11-13 | 民生药业集团有限公司 | A kind of dandelion herb tea is precious and its preparation process |
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