CN106420631B - A kind of preparation method of micropore sodium alginate-starch composite particles - Google Patents
A kind of preparation method of micropore sodium alginate-starch composite particles Download PDFInfo
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- CN106420631B CN106420631B CN201611011086.3A CN201611011086A CN106420631B CN 106420631 B CN106420631 B CN 106420631B CN 201611011086 A CN201611011086 A CN 201611011086A CN 106420631 B CN106420631 B CN 106420631B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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Abstract
The invention discloses a kind of preparation methods of micropore sodium alginate-starch composite particles, belong to the preparation technical field of sustained-release tablet particle.This method sprays hydrogen peroxide into food-grade sodium alginate first, it keeps the temperature at a certain temperature, the deionized water of 9-15 times of sodium alginate quality is then added, stirring to sodium alginate is completely dissolved, sodium alginate soln is obtained, by acquired solution by standing after centrifugation, removal of impurities；Starch emulsion is configured, and amylase is added thereto, after insulation reaction, the sodium alginate soln after standing is added thereto, mixed solution is obtained after stirring；Carbonate and glucolactone are finally added into mixed solution, stirs evenly, by spray drying, micropore sodium alginate-starch composite particles are made.The present invention is spraying by sodium alginate soln and starch blending, by the way that carbonate and glucolactone is added, increases the partial size of particle, improves the slow release effect of drug, and prilling is simple, reduce production cost.
Description
Technical field
The present invention relates to the preparation technical fields of sustained-release tablet particle, and in particular to a kind of micropore sodium alginate-starch
The preparation method of composite particles.
Background technique
Pharmaceutic adjuvant plays very important effect in the development of pharmaceutical preparation, and the exploitation of pharmaceutic adjuvant can push away preparation
The field new to one.Biodegradable auxiliary material is one of the research hotspot in field of medicaments in recent years.Because it is with good
The features such as biocompatibility, non-toxic and safe, provides wide space for its wide application in field of medicaments.
Sodium alginate is to be present in one of brown alga natural macromolecule amylose, by mannuronic acid and guluronic acid group
At with good biocompatibility, except the transmission for biopharmaceutical macromolecular drug (such as protein, vaccine) or cell
Outside matrix, sodium alginate can also be used to the sustained-release matrix of small-molecule drug, be the oral preparation of matrix preparation by sodium alginate
Drug molecule is able to extend in the action time of gastrointestinal mucosa, and improves the bioavilability of drug.Such as CN103720673A public affairs
Opened a kind of Nifedipine sodium alginate sustained release tablets, primary raw material composition are as follows: nifedipine, sodium alginate, microcrystalline cellulose,
Sodium phosphate dodecahydrate and calcium phosphate dibasic dihydrate, it is using sodium alginate as matrix, with preparing nitre benzene by direct compression method
Flat sustained release tablets.
However in currently available technology, when using sodium alginate preparation sustained release tablets, need to be granulated again, due to alginic acid
Sodium poor fluidity be easy to cause release poor, causes sustained release piece performance unstable.
Summary of the invention
The purpose of the present invention is to provide a kind of micropores that has the function of micro-porous adsorption and can be used directly on slow releasing pharmaceutical
Sodium alginate-starch composite particles preparation method.
Its technical solution includes:
A kind of preparation method of micropore sodium alginate-starch composite particles, successively the following steps are included:
A sprays hydrogen peroxide into food-grade sodium alginate, and the fountain height of the hydrogen peroxide is the 1%- of sodium alginate quality
2.5%, 6-18h is kept the temperature at 35-50 DEG C, and the deionized water of 9-15 times of sodium alginate quality, stirring to alginic acid is then added
Sodium is completely dissolved, and obtains sodium alginate soln, by acquired solution by standing after centrifugation, removal of impurities；
B prepares the starch emulsion that starch concentration is 30%-50%, and amylase, heat preservation is added by 400-600u/g starch
After reaction 1-2 hours, sodium alginate soln obtained by step a is added thereto, obtains mixed solution；
Carbonate and glucolactone are added into mixed liquor obtained by step b by c, stir evenly, are spray-dried, i.e.,
Micropore sodium alginate-starch composite particles are made.
In above-mentioned preparation method, using sodium alginate soln as sustained-release matrix, starch forms tool after starch enzymatic treatment
There is the porosity starch carrier of honeycomb aperture, multiple micropores possessed by surface have special adsorption function, by the two
It mixes and carbonate and glucolactone is added thereto, in spray-drying process, grape acid lactone is hydrolyzed to glucose
Acid produces carbon dioxide gas with carbonate reaction, forms the micropore size that bubble increases particle, the composite particles being prepared
Drug carrying capacity can be improved.
As a preferred solution of the present invention, in step a, the viscosity of the food-grade sodium alginate is 400-
600mpa.s。
As another preferred embodiment of the invention, in step a, the fountain height of the hydrogen peroxide is sodium alginate quality
1%-2%.
Preferably, in step c, the carbonate be one of sodium carbonate, potassium carbonate, sodium bicarbonate, ammonium hydrogencarbonate or
Two or more mixtures.
Preferably, in step c, the additive amount of the carbonate is the 0.2-1% of the mixed liquor weight, the carbonate
Mass ratio with glucolactone is 0.8-1:1.
Advantageous effects brought by the present invention are as follows:
(1) starch being obtained using enzymatic treatment and obtaining honeycomb aperture, carbonate and glucolactone is added spraying
Reaction generates atmospheric carbon dioxide in drying process, forms the micropore size that bubble increases particle, can improve drug carrying capacity；
(2) sodium alginate soln and starch blending are spraying, increase the partial size of particle, porous structure, addition grape acid
Lactone improves the slow release effect of drug；
(3) it improves starch granules, the characteristics of sodium alginate particle is unable to satisfy direct tablet compressing, passes through mist projection granulating, system
For a kind of particle for meeting direct tablet compressing function；
(4) prilling of the present invention is simple, and overall cost is remarkably decreased.
Specific embodiment
It is of the invention excellent in order to make the invention proposes a kind of preparation method of micropore sodium alginate-starch composite particles
Point, technical solution are clearer, clear, elaborate combined with specific embodiments below to the present invention.
Sodium alginate is food-grade sodium alginate in following selected raw materials；
Raw material needed for the present invention can be commercially available by commercial channel.
Embodiment 1:
Micropore sodium alginate-starch composite particles preparation method, specifically includes the following steps:
The first step, the food-grade sodium alginate 100g for weighing viscosity 550mpa.s (1% solution) spray hydrogen peroxide 1.5g,
8 hours are kept the temperature at 35 DEG C, 900g deionized water, stirring 0.5h or so is added, until sodium alginate is completely dissolved, tested viscosity is
890mpa.s (10% solution), glue are further cleaned by supercentrifuge；
Second step weighs starch 400g, and 600g deionized water is added, stirs evenly, and the alpha-amylase of 200,000 units is added,
It is stirred to react at 50 DEG C 1.5 hours, the above-mentioned prepared sodium alginate soln of addition, addition sodium carbonate 5g, in gluconic acid
Ester 6g, stirs evenly, and is spray-dried, and micropore sodium alginate-starch granules is obtained.
Embodiment 2:
Micropore sodium alginate-starch composite particles preparation method, specifically includes the following steps:
The first step, the food-grade sodium alginate 80g for weighing viscosity 480mpa.s (1% solution) spray hydrogen peroxide 1.2g,
10 hours are kept the temperature at 35 DEG C, 920g deionized water, stirring 0.5h or so is added, until sodium alginate is completely dissolved, tested viscosity is
870mpa.s (10% solution), glue are further cleaned by supercentrifuge；
Second step weighs starch 350g, and 650g deionized water is added, stirs evenly, and the alpha-amylase of 210,000 units is added,
It is stirred to react at 50 DEG C 1 hour, the above-mentioned prepared sodium alginate soln of addition, addition sodium carbonate 5.5g, in gluconic acid
Ester 6g, stirs evenly, and is spray-dried, and micropore sodium alginate-starch granules is obtained.
Embodiment 3:
Micropore sodium alginate-starch composite particles preparation method, specifically includes the following steps:
The first step, the food-grade sodium alginate 90g for weighing viscosity 590mpa.s (1% solution) spray hydrogen peroxide 1.8g,
12 hours are kept the temperature at 35 DEG C, 910g deionized water, stirring 0.5h or so is added, until sodium alginate is completely dissolved, tested viscosity is
850mpa.s (10% solution), glue are further cleaned by supercentrifuge；
Second step weighs starch 320g, and 680g deionized water is added, stirs evenly, and the alpha-amylase of 180,000 units is added,
It is stirred to react at 50 DEG C 0.5 hour, the above-mentioned prepared sodium alginate soln of addition, addition sodium carbonate 6g, in gluconic acid
Ester 7g, stirs evenly, and is spray-dried, and micropore sodium alginate-starch granules is obtained.
Embodiment 4:
Micropore sodium alginate-starch composite particles preparation method, specifically includes the following steps:
The first step, the food-grade sodium alginate 100g for weighing viscosity 400mpa.s (1% solution) spray hydrogen peroxide 1g,
6 hours are kept the temperature at 40 DEG C, adds 1500g deionized water, stirring 0.5h or so, until sodium alginate is completely dissolved, tested viscosity is
170mpa.s (6.25% solution), glue are further cleaned by supercentrifuge；
Second step weighs starch 400g, and 600g deionized water is added, stirs evenly, and the alpha-amylase of 200,000 units is added,
It is stirred to react at 50 DEG C 1.5 hours, the above-mentioned prepared sodium alginate soln of addition, addition sodium carbonate 5g, in gluconic acid
Ester 6g, stirs evenly, and is spray-dried, and micropore sodium alginate-starch granules is obtained.
Embodiment 5:
Micropore sodium alginate-starch composite particles preparation method, specifically includes the following steps:
The first step, the food-grade sodium alginate 100g for weighing viscosity 600mpa.s (1% solution) spray hydrogen peroxide 2.5g,
8 hours are kept the temperature at 35 DEG C, 1200g deionized water, stirring 0.5h or so is added, until sodium alginate is completely dissolved, tested viscosity
For 290mpa.s (7.69% solution), glue is further cleaned by supercentrifuge；
Second step weighs starch 400g, and 600g deionized water is added, stirs evenly, and the alpha-amylase of 200,000 units is added,
It is stirred to react at 50 DEG C 1.5 hours, above-mentioned prepared sodium alginate soln is added, sodium bicarbonate 5g, gluconic acid is added
Lactone 5g, stirs evenly, and is spray-dried, and micropore sodium alginate-starch granules is obtained.
Embodiment 6:
Micropore sodium alginate-starch composite particles preparation method, specifically includes the following steps:
The first step, the food-grade sodium alginate 100g for weighing viscosity 550mpa.s (1% solution) spray hydrogen peroxide 1.5g,
8 hours are kept the temperature at 35 DEG C, 900g deionized water, stirring 0.5h or so is added, until sodium alginate is completely dissolved, tested viscosity is
890mpa.s (10% solution), glue are further cleaned by supercentrifuge；
Second step weighs starch 500g, and 600g deionized water is added, stirs evenly, and the alpha-amylase of 200,000 units is added,
It is stirred to react at 50 DEG C 1.5 hours, the above-mentioned prepared sodium alginate soln of addition, addition sodium carbonate 5g, in gluconic acid
Ester 6.25g, stirs evenly, and is spray-dried, and micropore sodium alginate-starch granules is obtained.
Embodiment 7:
Difference from Example 1 is that the mixture of the potassium carbonate of the sodium carbonate in second step and sodium bicarbonate is come generation
It replaces.
Tabletting is examined: nifedipine crushed 120 mesh stainless steel mesh, by 12.5% nifedipine, 87% reality
Sodium alginate-starch granules prepared by example 1,0.5% magnesium stearate rush in row tabletting with 10mm circle；
Tablet is examined: surveying a release every sampling in 30 minutes, the present invention prepares the Nifedipine sustained-release of particle compacting
The variation of piece release profiles is regular, and difference is small between each, and release curve is good, overall merit, and particle prepared by embodiment 3 is slow
It is optimal to release effect.
The above-mentioned embodiment not enumerated can be realized obviously under the guide of embodiment 1-7.
It should be noted that any equivalent way that those skilled in the art are made under the introduction of this specification, or
Obvious variant should all be within the scope of the present invention.
Claims (5)
1. a kind of preparation method of micropore sodium alginate-starch composite particles, which is characterized in that successively the following steps are included:
A sprays hydrogen peroxide into food-grade sodium alginate, and the fountain height of the hydrogen peroxide is the 1%- of sodium alginate quality
2.5%, 6-18h is kept the temperature at 35-50 DEG C, and the deionized water of 9-15 times of sodium alginate quality, stirring to alginic acid is then added
Sodium is completely dissolved, and obtains sodium alginate soln, by acquired solution by standing after centrifugation, removal of impurities；
B prepares the starch emulsion that starch concentration is 30%-50%, and amylase, insulation reaction is added by 400-600u/g starch
After 1-2 hours, sodium alginate soln obtained by step a is added thereto, obtains mixed solution；
Carbonate and glucolactone are added into mixed liquor obtained by step b by c, stir evenly, are spray-dried, are obtained
Micropore sodium alginate-starch composite particles.
2. the preparation method of micropore sodium alginate-starch composite particles according to claim 1, it is characterised in that: step a
In, the viscosity of the food-grade sodium alginate is 400-600mpa.s.
3. the preparation method of micropore sodium alginate-starch composite particles according to claim 1, it is characterised in that: step a
In, the fountain height of the hydrogen peroxide is the 1%-2% of sodium alginate quality.
4. the preparation method of micropore sodium alginate-starch composite particles according to claim 1, it is characterised in that: step c
In, the carbonate is the mixture of one or more of sodium carbonate, potassium carbonate, sodium bicarbonate, ammonium hydrogencarbonate.
5. the preparation method of micropore sodium alginate-starch composite particles according to claim 1, it is characterised in that: step c
In, the additive amount of the carbonate is the quality of carbonate and glucolactone described in the 0.2-1%. of the mixed liquor weight
Than for 0.8-1:1.
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| CN108841814A (en) * | 2018-07-03 | 2018-11-20 | 北京师范大学 | The method for preparing sustained release carbon material based on polyvinyl alcohol, sodium alginate and starch |
| CN112609260B (en) * | 2021-01-15 | 2021-06-29 | 山东乐成佳纺服装有限公司 | Antibacterial fiber material and preparation process thereof |
| CN113876169A (en) * | 2021-09-08 | 2022-01-04 | 浙江真爱时尚家居有限公司 | Production method of high-density digital carpet |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1810867A (en) * | 2006-02-16 | 2006-08-02 | 武汉理工大学 | Prepn of sodium alginate/chitosan mixture gel |
| CN103341161A (en) * | 2013-06-20 | 2013-10-09 | 湖北省潜江市华山水产食品有限公司 | Preparation method for sodium alginate-lysozyme compound microcapsule |
| CN103585638A (en) * | 2013-11-21 | 2014-02-19 | 东华大学 | Preparation method for sodium alginate and calcium carbonate hybrid particles |
| CN104434879A (en) * | 2014-11-17 | 2015-03-25 | 黑龙江省兽医科学研究所 | Preparation method of chitosan-sodium alginate drug-loading micro-capsule |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1810867A (en) * | 2006-02-16 | 2006-08-02 | 武汉理工大学 | Prepn of sodium alginate/chitosan mixture gel |
| CN103341161A (en) * | 2013-06-20 | 2013-10-09 | 湖北省潜江市华山水产食品有限公司 | Preparation method for sodium alginate-lysozyme compound microcapsule |
| CN103585638A (en) * | 2013-11-21 | 2014-02-19 | 东华大学 | Preparation method for sodium alginate and calcium carbonate hybrid particles |
| CN104434879A (en) * | 2014-11-17 | 2015-03-25 | 黑龙江省兽医科学研究所 | Preparation method of chitosan-sodium alginate drug-loading micro-capsule |
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Effective date of registration: 20190902 Address after: 266500 Mingyue Road 777, Huangdao District, Qingdao City, Shandong Province Patentee after: Qingdao Bright Moon Seaweed Group Co., Ltd. Address before: 266500 Mingyue Road 777, Huangdao District, Qingdao City, Shandong Province Patentee before: Qingdao Yue Hai Pharmaceutical Technology Co., Ltd. |