CN106405115B - The special colloidal-gold detecting-card of lactoferrin in a kind of detection tear - Google Patents
The special colloidal-gold detecting-card of lactoferrin in a kind of detection tear Download PDFInfo
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- CN106405115B CN106405115B CN201611014934.6A CN201611014934A CN106405115B CN 106405115 B CN106405115 B CN 106405115B CN 201611014934 A CN201611014934 A CN 201611014934A CN 106405115 B CN106405115 B CN 106405115B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
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Abstract
The invention discloses a kind of special colloidal-gold detecting-cards of lactoferrin in detection tear,Including shell,The shell is hollow structure,Partition board is equipped in the shell,The inside of the shell is divided into three to eight sensing chamber by partition board,It is equipped with sliding rail on the both sides inner wall of the sensing chamber,The mobile base between two sliding rails is slidably connected on the sliding rail,It is pasted with test-strips in the top exterior walls of the mobile base,It is fixedly connected with limiting plate on the both sides outer wall of the test-strips,It is fixedly connected with baffle between the limiting plate,The baffle is fixedly connected with tear in the one side wall of test-strips and temporarily stores up pipe,The first glove channel and the second glove channel are respectively equipped in the top exterior walls and bottom outer wall of the sensing chamber,It is movably connected with head cover and the dust excluding plate of L-type in first glove channel and the second glove channel.Present invention is particularly suitable for the test environments that sample radix is larger.
Description
Technical field
The present invention relates to a kind of special colloidal golds of lactoferrin in the field of medical instrument technology more particularly to detection tear
Detection card.
Background technology
Lactoferrin is a kind of glycosylation albumen, the antibacterial functions with wide spectrum.Lactoferrin is mainly by lachrymal gland in tear
Secretion generates, and is collectively formed with tear lysozyme, tear prelbumin and a small amount of secretory immunoglobulin and growth factor
The main component of albumen, protects the eye surface not invaded by foreign object in tear.Scheroma is a kind of common disease, is clinically examined
The inspection of trunk snap eye disease includes lacrimal secretion experiment, breakup time of tear film, conjunctival epithelium dyeing, impression cytology inspection, molten
Bacterium enzyme content detection, lactoferrin content detection etc..The content of tear lactoferrin is relatively stablized, newborn iron in normal tear fluid
For the content of albumen between 1.14 ~ 1.78g/L, repeatability preferably, can if lactoferrin content is less than 0.9g/L in tear
It is diagnosed as scheroma.
The detection method of lactoferrin mainly has spectrophotometry and high performance liquid chromatography etc. in tear.Spectrophotometry
It is easy to operate with high performance liquid chromatography, but need the sample size detected bigger, and the amount of tear sample is considerably less, therefore not
The detection of lactoferrin suitable for tear.
Application No. is 201320403808.5（The special colloidal-gold detecting-card of lactoferrin in a kind of detection tear）Have
Beneficial effect is：The method for detecting lactoferrin content in tear with colloidal-gold detecting-card of the present invention, advantage are detection institutes
Need ocular fluid samples amount few, and easy to use, detection quickly, high sensitivity, result it is accurate.
But be only applicable to quickly detect independent sample or the smaller sample of radix in above-mentioned file, due to every test one
It is secondary just to need to clean well, and test-strips are replaced, it is larger for population bases such as student group or company personnel
Test environment for, the above method is just less applicable.
Invention content
The purpose of the present invention is to solve disadvantages existing in the prior art, and newborn iron in a kind of detection tear proposed
The special colloidal-gold detecting-card of albumen.
To achieve the goals above, present invention employs following technical solutions：
The special colloidal-gold detecting-card of lactoferrin in a kind of detection tear, including shell, the shell are hollow structure,
It is equipped with partition board in the shell, the inside of the shell is divided into three to eight sensing chamber by partition board, and the two of the sensing chamber
It is equipped with sliding rail on the inner wall of side, the mobile base between two sliding rails, the activity are slidably connected on the sliding rail
It is pasted with test-strips in the top exterior walls of pedestal, limiting plate, the limit have been fixedly connected on the both sides outer wall of the test-strips
Baffle is fixedly connected between the plate of position, the top exterior walls of the baffle are arcuate structure, and the baffle is close to the side of test-strips
It is fixedly connected with tear on wall and temporarily stores up pipe, the outlet end mouth that the tear temporarily stores up pipe is located at the surfaces of test-strips, the detection
The first glove channel and the second glove channel are respectively equipped in the top exterior walls and bottom outer wall of room, the test-strips pass through first
It is connected outside glove channel and sensing chamber, head cover has been movably connected in first glove channel and the second glove channel
With the dust excluding plate of L-type.
Preferably, the top exterior walls of the baffle are equipped with drainage trough, and the bottom of the drainage trough is located at tear and temporarily stores up pipe
Surface.
Preferably, the tear temporarily stores up pipe and is made of plastic material.
Preferably, it is equipped with fastener in the top exterior walls and one side wall of the sensing chamber, the head cover and sensing chamber
Top exterior walls and dust excluding plate and the side outer wall of sensing chamber are articulated and connected by fastener respectively.
Preferably, it is fixedly connected with sliding block on the both sides outer wall of the mobile base, the sliding block is slidably connected and sliding rail
It is interior.
Preferably, skid resistant course is fixedly connected on the outer wall of the shell, the skid resistant course is made of rubber material.
In the present invention, the design of head cover and dust excluding plate makes test-strips be located in shell, avoids test-strips and is corroded by dust,
Also it is avoided that test-strips are polluted by adjacent test sample, the baffle top exterior walls of arcuate structure are set according to human eyeball's shape
Meter facilitates collection tear, the design of drainage trough to make tear quickly and accurately flow into tear and temporarily store up in pipe, avoid tear
Waste, the design that pipe is temporarily stored up by tear enable the volume of the tear reacted with test-strips until control so that measure number
According to more acurrate, it is particularly suitable for the larger test environment of the population bases such as student group or company personnel.
Description of the drawings
Fig. 1 is the structural representation of the special colloidal-gold detecting-card of lactoferrin in a kind of detection tear proposed by the present invention
Figure；
Fig. 2 is the sectional view of the special colloidal-gold detecting-card of lactoferrin in a kind of detection tear proposed by the present invention.
In figure：1 shell, 2 partition boards, 3 sliding rails, 4 mobile bases, 5 test-strips, 6 limiting plates, 7 baffles, 8 tears temporarily store up pipe, 9
Head cover, 10 dust excluding plates.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
Referring to Fig.1-2, in a kind of detection tear lactoferrin special colloidal-gold detecting-card, including shell 1, shell 1 be
Hollow structure, is equipped with partition board 2 in shell 1, and the inside of shell 1 is divided into three to eight sensing chamber by partition board 2, and the two of sensing chamber
It is equipped with sliding rail 3 on the inner wall of side, the mobile base 4 between two sliding rails 3, mobile base 4 are slidably connected on sliding rail 3
Top exterior walls on be pasted with test-strips 5, limiting plate 6 has been fixedly connected on the both sides outer wall of test-strips 5, between limiting plate 6
It is fixedly connected with baffle 7, the top exterior walls of baffle 7 are arcuate structure, and baffle 7 is fixedly connected in the one side wall of test-strips 5
There is tear temporarily to store up pipe 8, the outlet end mouth that tear temporarily stores up pipe 8 is located at the surfaces of test-strips 5, the top exterior walls of sensing chamber and bottom
Be respectively equipped with the first glove channel and the second glove channel on outer wall, test-strips 5 by the first glove channel and sensing chamber outside
It is connected, head cover 9 and the dust excluding plate 10 of L-type is movably connected in the first glove channel and the second glove channel, baffle 7
Top exterior walls are equipped with drainage trough, and the bottom of drainage trough is located at the surface that tear temporarily stores up pipe 8, and it is plastics material that tear, which temporarily stores up pipe 8,
Matter is made, and is equipped with fastener in the top exterior walls and one side wall of sensing chamber, top exterior walls of head cover 9 and sensing chamber and dust-proof
Plate 10 and the side outer wall of sensing chamber are articulated and connected by fastener respectively, are fixedly connected on the both sides outer wall of mobile base 4
Sliding block, sliding block, which is slidably connected to move with the side that head cover 9 and dust excluding plate 10 in sliding rail 3, are first directed away to test-strips 5, makes test
Item 5 is connected to by the first glove channel and the second glove channel and 1 outside of shell, by mobile base 4 towards the side of test-strips 5
It is mobile so that the top of baffle 7 is moved to 1 outside of shell, and the top exterior walls of the baffle 7 of arcuate structure are placed under the eyelid of people
Side, tear enter tear and temporarily store up pipe 8 by the top exterior walls and drainage trough of baffle 7, and the tear that pipe 8 makes temporarily is stored up by squeezing tear
Liquid is fallen in test-strips 5, then by the top exterior walls and dust excluding plate 10 of head cover 9 and sensing chamber and is detected by fastener respectively
The side outer wall connection of room, then moves adjacent head cover 9 and dust excluding plate 10, repeats the above steps, until whole samples are surveyed
Examination finishes, easy to detect.
Operation principle：Head cover 9 and dust excluding plate 10 are first directed away to the side movement of test-strips 5 makes test-strips 5 by the
One glove channel and the second glove channel are connected to 1 outside of shell, and mobile base 4 is moved towards the side of test-strips 5 so that
The top of baffle 7 is moved to 1 outside of shell, the top exterior walls of the baffle 7 of arcuate structure is placed in below the eyelid of people, tear warp
It crosses the top exterior walls of baffle 7 and drainage trough enters tear and temporarily stores up pipe 8, temporarily store up the tear that pipe 8 makes and fall by squeezing tear and surveying
In strip 5, then respectively by fastener by the top exterior walls and dust excluding plate 10 of head cover 9 and sensing chamber and the side of sensing chamber
Outer wall connects, and then moves adjacent head cover 9 and dust excluding plate 10, repeats the above steps, until whole samples are completed.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (6)
1. the special colloidal-gold detecting-card of lactoferrin in a kind of detection tear, including shell（1）, which is characterized in that the shell
Body（1）For hollow structure, the shell（1）It is interior to be equipped with partition board（2）, the shell（1）Inside pass through partition board（2）It is divided into three
To eight sensing chamber, sliding rail is equipped on the both sides inner wall of the sensing chamber（3）, the sliding rail（3）On slidably connect position
In two sliding rails（3）Between mobile base（4）, the mobile base（4）Top exterior walls on be pasted with test-strips（5）, institute
State test-strips（5）Both sides be equipped with limiting plate（6）, the limiting plate（6）It is fixedly connected on mobile base（4）Top exterior walls
On, the limiting plate（6）Between be fixedly connected with baffle（7）, the baffle（7）Top exterior walls be arcuate structure, the gear
Plate（7）Close to test-strips（5）One side wall on be fixedly connected with tear and temporarily store up pipe（8）, the tear temporarily stores up pipe（8）Outlet end
Mouth is located at test-strips（5）Surface, be respectively equipped with the first glove channel in the top exterior walls and bottom outer wall of the sensing chamber
With the second glove channel, the test-strips（5）By being connected outside the first glove channel and sensing chamber, first glove is logical
It is movably connected with head cover in road and the second glove channel（9）With the dust excluding plate of L-type（10）.
2. the special colloidal-gold detecting-card of lactoferrin in a kind of detection tear according to claim 1, which is characterized in that
The baffle（7）Top exterior walls be equipped with drainage trough, the bottom of the drainage trough is located at tear and temporarily stores up pipe（8）Surface.
3. the special colloidal-gold detecting-card of lactoferrin, feature exist in a kind of detection tear according to claim 1 or 2
In the tear temporarily stores up pipe（8）It is made of plastic material.
4. the special colloidal-gold detecting-card of lactoferrin in a kind of detection tear according to claim 1, which is characterized in that
Fastener, the head cover are equipped in the top exterior walls and one side wall of the sensing chamber（9）With the top exterior walls of sensing chamber and
Dust excluding plate（10）It is articulated and connected respectively by fastener with the side outer wall of sensing chamber.
5. the special colloidal-gold detecting-card of lactoferrin in a kind of detection tear according to claim 1, which is characterized in that
The mobile base（4）Both sides outer wall on be fixedly connected with sliding block, the sliding block is slidably connected to sliding rail（3）It is interior.
6. the special colloidal-gold detecting-card of lactoferrin in a kind of detection tear according to claim 1, which is characterized in that
The shell（1）Outer wall on be fixedly connected with skid resistant course, the skid resistant course is made of rubber material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611014934.6A CN106405115B (en) | 2016-11-18 | 2016-11-18 | The special colloidal-gold detecting-card of lactoferrin in a kind of detection tear |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611014934.6A CN106405115B (en) | 2016-11-18 | 2016-11-18 | The special colloidal-gold detecting-card of lactoferrin in a kind of detection tear |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106405115A CN106405115A (en) | 2017-02-15 |
| CN106405115B true CN106405115B (en) | 2018-07-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611014934.6A Active CN106405115B (en) | 2016-11-18 | 2016-11-18 | The special colloidal-gold detecting-card of lactoferrin in a kind of detection tear |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113721013B (en) * | 2021-11-02 | 2022-02-22 | 首都医科大学附属北京朝阳医院 | Eye surface liquid collecting and detecting device |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992015861A1 (en) * | 1991-02-27 | 1992-09-17 | Boehringer Mannheim Corporation | Test strip holding and reading meter |
| CN102445414A (en) * | 2011-09-21 | 2012-05-09 | 艾康生物技术(杭州)有限公司 | Test device used for medical examination |
| CN203385736U (en) * | 2013-07-08 | 2014-01-08 | 无锡安迪生物工程有限公司 | Colloidal gold detection card specially used for detecting lactoferrin in tear |
| CN203698977U (en) * | 2013-12-12 | 2014-07-09 | 李欣欣 | Test paper box used for testing diabetes for endocrinology department |
| CN204269669U (en) * | 2014-11-28 | 2015-04-15 | 浙江世纪康大医疗科技股份有限公司 | A kind of Test paper places push pedal |
| CN205229165U (en) * | 2015-12-25 | 2016-05-11 | 合肥安为康医学检验有限公司 | Detect reagent box of first child albumen |
| CN205665230U (en) * | 2016-06-07 | 2016-10-26 | 安徽宏远职业卫生技术服务有限公司 | Quick detection device of food security |
-
2016
- 2016-11-18 CN CN201611014934.6A patent/CN106405115B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992015861A1 (en) * | 1991-02-27 | 1992-09-17 | Boehringer Mannheim Corporation | Test strip holding and reading meter |
| CN102445414A (en) * | 2011-09-21 | 2012-05-09 | 艾康生物技术(杭州)有限公司 | Test device used for medical examination |
| CN203385736U (en) * | 2013-07-08 | 2014-01-08 | 无锡安迪生物工程有限公司 | Colloidal gold detection card specially used for detecting lactoferrin in tear |
| CN203698977U (en) * | 2013-12-12 | 2014-07-09 | 李欣欣 | Test paper box used for testing diabetes for endocrinology department |
| CN204269669U (en) * | 2014-11-28 | 2015-04-15 | 浙江世纪康大医疗科技股份有限公司 | A kind of Test paper places push pedal |
| CN205229165U (en) * | 2015-12-25 | 2016-05-11 | 合肥安为康医学检验有限公司 | Detect reagent box of first child albumen |
| CN205665230U (en) * | 2016-06-07 | 2016-10-26 | 安徽宏远职业卫生技术服务有限公司 | Quick detection device of food security |
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