CN1063973C - Preparation of nonadhesive dressing bactericidal and hemostatic - Google Patents
Preparation of nonadhesive dressing bactericidal and hemostatic Download PDFInfo
- Publication number
- CN1063973C CN1063973C CN 98101676 CN98101676A CN1063973C CN 1063973 C CN1063973 C CN 1063973C CN 98101676 CN98101676 CN 98101676 CN 98101676 A CN98101676 A CN 98101676A CN 1063973 C CN1063973 C CN 1063973C
- Authority
- CN
- China
- Prior art keywords
- handled
- absorbent carbasus
- dressing
- solution
- absorbent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000002360 preparation method Methods 0.000 title claims description 8
- 230000000844 anti-bacterial effect Effects 0.000 title claims description 3
- 230000002439 hemostatic effect Effects 0.000 title description 3
- 238000001035 drying Methods 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000006386 neutralization reaction Methods 0.000 claims abstract description 4
- 238000005406 washing Methods 0.000 claims abstract description 4
- 230000015556 catabolic process Effects 0.000 claims abstract description 3
- 238000006731 degradation reaction Methods 0.000 claims abstract description 3
- 230000002745 absorbent Effects 0.000 claims description 28
- 239000002250 absorbent Substances 0.000 claims description 28
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 claims description 6
- 230000023597 hemostasis Effects 0.000 claims description 6
- 230000003115 biocidal effect Effects 0.000 claims description 5
- 238000006266 etherification reaction Methods 0.000 claims description 5
- 238000003672 processing method Methods 0.000 claims description 5
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 4
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 4
- 238000012856 packing Methods 0.000 claims description 3
- 238000012360 testing method Methods 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims description 2
- 235000011194 food seasoning agent Nutrition 0.000 claims description 2
- 238000005554 pickling Methods 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 abstract description 17
- 206010052428 Wound Diseases 0.000 abstract description 16
- 238000000034 method Methods 0.000 abstract description 5
- 230000000740 bleeding effect Effects 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 206010048038 Wound infection Diseases 0.000 abstract description 2
- 230000007704 transition Effects 0.000 abstract description 2
- 229920000742 Cotton Polymers 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 9
- 208000032843 Hemorrhage Diseases 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a method for preparing medical dressings which resist bacteria, stop bleeding and do not adhere with wounds. The method has the steps of immersing defatting gauze in acid for degradation; carrying out graft etherifying reaction and neutralization reaction; washing and immersing the defatting gauze in an antibacterial agent; drying the defatting gauze by steam, etc. A dressing prepared by the method changes the nature of cotton fiber, and greatly enhances the water absorption of the cotton fiber. A gel-type transition layer can be formed between the dressing and a wound to ensure that the dressing is easy to separate from the wound, and the dressing contains antibacterial agents to prevent wound infection. The products prepared by the present invention can be widely applied to various wounds, and is especially suitable for the emergency treatment of field (field training) injury.
Description
The present invention relates to a kind of processing method of medical dressing.
It has been generally acknowledged that a kind of dressing helps stopping blooding and just very strong water absorption should be arranged, then do not need dressing that good hydrophobicity is arranged with the wound adhesion, two kinds of diametrically opposite requirements of character are difficult in identical material dressing and embody.Actual to show that dressing only has a product of simple function a lot, and hemostasis and adhesion function have both at the same time and embodied from the dressing layer structure according to the knowledge of the applicant, for example at the compound one deck of gauze hemorrhage coating surface hydrophobic film with holes or the like.
The purpose of this invention is to provide a kind of dressing materials itself have hemostasis and with antibiotic, the hemostasis of two kinds of functions of wound adhesion and the processing method of wound adhesion medical dressing.
Processing method of the present invention is carried out according to following steps:
Step 1, absorbent carbasus pickling degradation treatment:
(1) preparation monochloroacetic acid solution, 95% industrial alcohol: monochloroacetic acid=1: 0.6-0.7 (weight ratio),
(2) at normal temperatures, absorbent carbasus is immersed in the above-mentioned solution 50-70 minute;
Step 2, the 1st drying are handled:
The absorbent carbasus of handling through step 1 dries in centrifugal swing dryer, does not only throw away to there being solution;
Step 3, grafting etherification reaction are handled:
(1) the full solution, 75% industrial alcohol of closing of preparation sodium hydroxide: sodium hydroxide=1: 0.4 (weight ratio)
(2) absorbent carbasus that step 2 is handled immerses in the above-mentioned solution and moves back and forth, and the grafting etherification reaction time is 180-240 minute at normal temperatures;
Step 4, the 2nd drying are handled, with step 2;
Step 5, neutralisation treatment:
(1) at normal temperatures, the absorbent carbasus that step 4 is handled immerse 95% industrial wine clear in, and move back and forth;
(2) splash into hydrochloric acid solution simultaneously, test the pH value of processed absorbent carbasus, to PH=7.6-5.4;
Step 6, the 3rd drying are handled, with step 2;
Step 7, carrying out washing treatment:
Immerse the absorbent carbasus of step 6 in 95% industrial alcohol and move back and forth, to absorbent carbasus surface noresidue;
Step 8, the 4th dry to be handled, with step 2;
Step 9, dipping antibacterial are handled:
(1) preparation chlorhexidine acetate solution, 95% industrial alcohol: chlorhexidine acetate=1: 0.006 (weight ratio);
(2) absorbent carbasus with step 8 immerses in the above-mentioned solution, and dip time is 20 minutes under the room temperature;
Step 10, dried:
(1) with the absorbent carbasus drop liquid of step 9 to there not being dropping liquid;
(2) the absorbent carbasus steam seasoning behind the drop liquid, water content＜15%;
Step 11 is cut out, arrangement, packing.
Use absorbent carbasus that this method handles to have excellent antibiotic, hemostasis and adhesion effect hereinafter to be referred as this dressing, the result is as follows for its contrast test:
Anti-microbial property detects:
Experimental strain: escherichia coli ATCC8099 and staphylococcus aureus ATCC6538.
Anti-microbial property is measured: with reference to the appendix B of GB15979-1995 " disposable use hygienic article sanitary standard ", only negative control adopts the common gauze of homogeneity.
Get 1.5 * 2cm with aseptic formality
2This dressing and homogeneity gauze put into aseptic plate, (content is 3.6 * 10 to drip the level bacterium liquid to be checked of 0.1ml
6/ ml), acting on and put into the shake well in vitro that contains 5mlPBS after 30 minutes, and make the diluent of three adjacent concentration, each concentration is got 0.5ml * 3 plates and is made count plate.And put 37 ℃ and cultivate 24 hours observed results such as following table:
The average clump count of sample title (cfu/ sheet) sterilizing rate %
This dressing 2,244 86.7
Common gauze 16872--
Anastalsis detects:
This experiment White Rabbit: posterior auricular artery place, every rabbit left and right sides unhairing, treat cross-section blood vessel after the angioplerosis; get this dressing and contrast hemostatic gauze 2 * 3cm bilayer; common gauze 2 * 3cm spreads on each wound respectively for six layers; and establish and add pressure zone thereon; observe no bloodstain and continue infiltration and be bleeding stopping period, and throw off this dressing and the confirmation of other gauze.
Haemostatic effect such as following table: this dressing of sample title number of animals bleeding stopping period (branch) P value 20 1.64 ± 1.04＜0.05 contrast hemostatic gauze 14 2.29 ± 1.03＞0.05 common gauze 20 2.71 ± 1.27
Adhesion detects:
At each White Rabbit spinal column both sides unhairing baring skin area 3 * 4cm
2, make it be the diffuse hemorrhage point with the horizontal scraping of sawtooth, area is not less than 2 * 2cm
2, the both sides wound covers this dressing 3 * 3cm respectively
24 layers, common gauze 3 * 3cm
28 layers, use non-stimulated immobilization with adhesive tape, rabbit is free movable 24, the time after, observed result, comparing result such as following table:
Sample title number of animals adhesion number
This dressing 10 0
Common gauze 10 9
The dressing mechanism of action that the present invention obtained is: the degeneration after treatment of textile fiber, its water absorbing properties has had great enhancing, can absorb tens times and even tens times moisture content of own wt at short notice, when it contacts promptly moisture content in the absorbing blood rapidly and in large quantities with wound, the PC that wound overflows in the blood is increased, blood flow slows down, and promote the thrombinogen activation, thereby accelerate blood is solidified.Form the gel transition zone between this dressing simultaneously and the wound, make wound be easy to separate with this dressing.In addition, the water absorption of this dressing is reversible, even big or dryly make that wound and this dressing are dry and hard to be one owing to amount of bleeding, only need soak into this dressing with a little normal saline or sterilized water and soften with regard to making its suction very soon, this dressing can be removed, and can not cause the secondary wound.
Owing to introduced antibiotic substance in this method, therefore can prevent the wound infection accelerating wound healing again.
Embodiment: in reactive tank, add concentration and be 60% monochloroacetic acid alcoholic solution 50Kg, i.e. 95% industrial alcohol 30Kg, monochloroacetic acid 20Kg immerses 40 meters of absorbent carbasuss (fabric width 0.8) 60 minutes at normal temperatures; Taking out the back dries in centrifuge, observing no obvious residual liquid throws away and gets final product, preparation sodium hydroxide saturated solution 56Kg in reactive tank, i.e. 75% industrial alcohol 40Kg, sodium hydroxide 16Kg, will absorbent carbasus immerse reactive tank and stir and it is moved back and forth carry out the grafting etherification reaction by splash bar through drying, room temperature continues 240 minutes down, the taking-up absorbent carbasus dries, immersion is equipped with in the reactive tank of 95% industrial alcohol and is stirred when it is moved back and forth, splash into hydrochloric acid in groove, surveying processed absorbent carbasus surface pH value and be 6 is that neutralisation treatment is finished.The taking-up absorbent carbasus dries, and immerses extremely surperficial noresidue of washing in the reactive tank that 95% industrial alcohol is housed, and takes out drop liquid, send in the Steaming oven and dries, and surveys its water content and gets final product less than 15% o'clock.Be cut into 5 * 8 or 5 * 15mm lamellar after packing promptly get product.
Claims (1)
1, the processing method of antibiotic, hemostasis and wound adhesion medical dressing is characterized in that: carry out according to following steps--
Step 1, absorbent carbasus pickling degradation treatment:
(1) preparation monochloroacetic acid solution, 95% industrial alcohol: monochloroacetic acid=1:0.6-0.7 (weight ratio);
(2) at normal temperatures, absorbent carbasus is immersed in the above-mentioned solution 50-70 minute;
Step 2, the 1st drying are handled:
The absorbent carbasus of handling through step 1 dries in centrifugal swing dryer, does not only throw away to there being solution;
Step 3, grafting etherification reaction are handled:
(1) the full solution, 75% industrial alcohol of closing of preparation sodium hydroxide: sodium hydroxide=1: 0.4 (weight ratio)
(2) absorbent carbasus that step 2 is handled immerses in the above-mentioned solution and moves back and forth, and the grafting etherification reaction time is 180-240 minute at normal temperatures;
Step 4, the 2nd drying are handled, with step 2;
Step 5, neutralisation treatment:
(1) at normal temperatures, the absorbent carbasus that step 4 is handled immerses in 95% industrial alcohol, and moves back and forth;
(2) splash into hydrochloric acid solution simultaneously, test the pH value of processed absorbent carbasus, to PH=7.6-5.4;
Step 6, the 3rd drying are handled, with step 2;
Step 7, carrying out washing treatment:
Immerse the absorbent carbasus of step 6 in 95% industrial alcohol and move back and forth, to absorbent carbasus surface noresidue;
Step 8, the 4th dry to be handled, with step 2;
Step 9, dipping antibacterial are handled:
(1) preparation chlorhexidine acetate solution, 95% industrial alcohol: chlorhexidine acetate=1: 0.006 (weight ratio);
(2) absorbent carbasus with step 8 immerses in the above-mentioned solution, and dip time is 20 minutes under the room temperature;
Step 10, dried:
(1) with the absorbent carbasus drop liquid of step 9 to there not being dropping liquid;
(2) the absorbent carbasus steam seasoning behind the drop liquid, water content＜15%;
Step 11 is cut out, arrangement, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98101676 CN1063973C (en) | 1998-04-30 | 1998-04-30 | Preparation of nonadhesive dressing bactericidal and hemostatic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98101676 CN1063973C (en) | 1998-04-30 | 1998-04-30 | Preparation of nonadhesive dressing bactericidal and hemostatic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1201696A CN1201696A (en) | 1998-12-16 |
| CN1063973C true CN1063973C (en) | 2001-04-04 |
Family
ID=5216861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 98101676 Expired - Fee Related CN1063973C (en) | 1998-04-30 | 1998-04-30 | Preparation of nonadhesive dressing bactericidal and hemostatic |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1063973C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101543640B (en) * | 2008-03-27 | 2014-03-12 | 张博 | Absorbable, conglutination preventing and styptic power product and preparation method thereof |
| CN101543639B (en) * | 2008-03-27 | 2013-12-04 | 张博 | Soluble and absorbable medical treatment product based on natural fiber and preparation method thereof |
| CN101961505A (en) * | 2010-09-28 | 2011-02-02 | 北京纺织科学研究所 | Methods for preparing medical anti-adhesion hemostatic material and medical anti-adhesion hemostatic washing fluid |
| CN103397509A (en) * | 2013-08-07 | 2013-11-20 | 武汉纺织大学 | Preparation method for antibacterial liquid-absorbing gauze |
| CN111228040B (en) * | 2020-01-08 | 2021-06-25 | 河南亚都实业有限公司 | Absorbable anti-adhesion dressing and preparation method thereof |
-
1998
- 1998-04-30 CN CN 98101676 patent/CN1063973C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1201696A (en) | 1998-12-16 |
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