CN106389655A - Drug for treating HepatitisBHBeAg of HBV (hepatitis B virus) and preparation method of drug - Google Patents

Drug for treating HepatitisBHBeAg of HBV (hepatitis B virus) and preparation method of drug Download PDF

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CN106389655A
CN106389655A CN201611026337.5A CN201611026337A CN106389655A CN 106389655 A CN106389655 A CN 106389655A CN 201611026337 A CN201611026337 A CN 201611026337A CN 106389655 A CN106389655 A CN 106389655A
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parts
root
medicine
hepatitis
drug
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何新霞
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Guangxi University
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a drug for treating HepatitisBHBeAg of HBV (hepatitis B virus) and a preparation method of the drug. The drug is prepared from, by weight, 1-4 parts of pomelo peel, 2-4 parts of vajazzle, 1-4 parts of Chinese wampee fruit, 2-5 parts of fermented soybean, 2-7 parts of solanum melongena, 2-5 parts of radish seeds, 1-6 parts of rhizoma atractylodis, 1-3 parts of kawazure, 1-4 parts of radix bupleuri, 1-3 parts of tortoiseshell, 1-4 parts of radix paeoniae alba, 1-4 parts of radix scutellariae, 1-5 parts of radix isatidis, 0.5-3 parts of felwort and 3-6 parts of eucommia ulmoides. The purpose of developing a prescription suitable for crowds and stable in pharmacological effect is achieved; by the addition of traditional Chinese medicine materials of solanum melongena, pomelo peel and the like, nursing function can be achieved during treatment, functions of internal organs can be co-harmonized, and meanwhile, the liver is protected.

Description

Medicine for the treatment of hepatitis B great three positive and preparation method thereof
Technical field
Invention belongs to pharmaceutical technology field and in particular to a kind of medicine treating hepatitis B great three positive and preparation method thereof.
Background technology
Virus B hepatitis（Hepatitis B）By hepatitis type B virus（HBV）Infect the disease causing, China there are about 100,000,000 2 thousand Ten thousand chronic infection, is one of public health problem of China's most serious, and the annual medical expense that consumes is up to 300～50,000,000,000 Yuan.At present, the principle of reatment of hepatitis B need three points of medicines control, seven points of conditionings.Using such as Lamivudine, interferon, Although instant effect during the western medicine hepatitis B such as Entecavir, but easy recurrent exerbation, costly, secondary to the poison of hepatic and renal function Effect is big, thus can not meet clinical demand.More and more carry out treating hepatitis B using Chinese medicine now, but, existing Chinese medicine During treatment hepatitis B, there is treatment cycle length, unsatisfactory curative effect, thus can not thoroughly cure hepatitis B, bring body to patient Body and spiritual dual injury.
Content of the invention
For above-mentioned deficiency, the invention provides a kind of medicine treating hepatitis B great three positive and preparation method thereof, The medicine of the present invention and preparation method are safe and simple, good, the no pain of inexpensive effect, are deeply welcome by hepatitis B patient and family members.
To achieve these goals, the technical solution used in the present invention is as follows：
A kind of medicine treating hepatitis B great three positive is it is characterised in that described medicine is made up of following medicinal material by weight：
Pomelo peel 1-4 part；Golden contracted payment 2-4 part；Calusena lansium parasitism 1-4 part；Fermented Soybean 2-5 part；Eggplant root 2-7 part；Radish seed 2-5 Part；Bighead atractylodes rhizome 1-6 part；River connects 1-3 part；Radix bupleuri 1-4 part；Tortoiseshell 1-3 part；Root of herbaceous peony 1-4 part；Root of large-flowered skullcap 1-4 part；Isatis root 1-5 part；Dragon Courage grass 0.5-3 part；Bark of eucommia 3-6 part.
Further, described medicine is made up of following medicinal material by weight：
3 parts of pomelo peel；3 parts of golden contracted payment；Parasitic 2 parts of Calusena lansium；3 parts of Fermented Soybean；5 parts of eggplant root；3 parts of radish seed；4 parts of the bighead atractylodes rhizome；River Even 2 parts；2 parts of radix bupleuri；2 parts of tortoiseshell；3 parts of the root of herbaceous peony；2 parts of the root of large-flowered skullcap；3 parts of isatis root；1.5 parts of felwort；4 parts of the bark of eucommia.
Further, the medicine of described big hepatitis B three sun for the treatment of includes following preparation process：
1) mix after the smalls above-mentioned a kind of bulk drug being respectively crushed into 0.3-0.4 sieve；
2) soak, amount of water is 3-4 times of the total amount of described bulk drug；
3), after soaking 1 hour, decoct；
4) extract decoction liquor, and be concentrated into 1-2 times of concentration, make gained pharmaceutical solutions.
Specifically, described step 3）Including：
The amount of water decocting for the first time is 4 times of raw material gross weight, decocts 3 hours；After filtration, add water in filter residue, decoct for second The amount of water boiling is 5 times of raw material gross weight, decocts 2 hours；After filtration, add water in filter residue, the amount of water that third time decocts is 3 times of raw material gross weight, decoct 1 hour.
In the Chinese medicine for the treatment of hepatitis B that the present invention provides, each raw material act as：
Radix bupleuri：Taste is pungent, hardship, cold nature, in having and inducing sweat, soothing liver-qi stagnation, yang invigorating, the effect of preventing malaria of bringing down a fever；
Pomelo peel：Sanguimotor viscosity can be dropped, reduce the formation of thrombus；
Golden contracted payment：Sweet, tremble with fear, heat-clearing, promote the production of body fluid, promoting blood circulation, removing toxic substances.Cure mainly pyreticosis dry thirsty, eruptive disease, heat is rushed down, lung carbuncle, hemoptysis, laryngalgia, hemorrhoid Blood, gonorrhoea, carbuncle poison；
Calusena lansium is parasitic：A surname removes stagnant heat, and manages colic；
Fermented Soybean：Induce sweat, relieving restlessness, Xuan Yu, merit of removing toxic substances is imitated.For typhoid fever pyreticosis, fever and chills, have a headache, irritated, uncomfortable in chest；
Eggplant root：Clearing heat and promoting diuresis, dispelling wind stopping cough, astringing to arrest bleeding.For rheumatic arthritis, senile chronic tracheitis, oedema, long Cough, protracted dysentery, leukorrhea, seminal emission, hematuria, have blood in stool；
Radish seed：For retention of food and drink, abdominal distention, constipation, stagnant rush down dysentery, phlegm heap soil or fertilizer over and around the roots is breathed with cough；
The bighead atractylodes rhizome：Spleen beneficial gas, eliminate dampness and have diuretic effect, hidroschesis, antiabortive.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, Fetal irritability；
River is even：Bitter cold in nature, belongs to the key medicine controlling dampness-heat in middle jiao；
Tortoiseshell:Enriching yin, checking exuberance of yang, kidney tonifying, strong bone；
The root of herbaceous peony：Smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating；
The root of large-flowered skullcap：Bitter, cold in nature, have heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive the effects such as；
Isatis root：Antiviral, antibacterium, anti-Leptospira, detoxication, improve immunity, antitumor action, to leukaemia work With；
Felwort：Cure mainly jaundice with damp-heat pathogen；Urine leaching pain；Swelling of vulva pruritus vulvae；Under humid tropics；The alliteration headache of liver and gall excess fire；Hot eyes swells Bitterly；Deaf ear swells；Hypochondriac pain bitter taste；Pyreticosis convulsion；
The bark of eucommia：The bark of eucommia has filling liver kidney, controls spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination, hypertension, antiabortive work( Effect.
In sum, the present invention has advantages below due to employing such scheme, the present invention：
Medicine for the treatment of hepatitis B great three positive of the present invention and preparation method thereof, any crowd is all suitable for this prescription, efficacy stability.Plus Enter the chinese medicine materials such as eggplant root, pomelo peel, opsonic action can have been played over the course for the treatment of, made the function of the vital organs of the human body mutual Coordinate, simultaneously work as the effect of liver protecting.
Specific embodiment
With reference to embodiment medicine for the treatment of hepatitis B great three positive a kind of to the present invention and preparation method thereof, make furtherly Bright.
First, prepare embodiment
Embodiment 1：
A kind of medicine treating hepatitis B great three positive is it is characterised in that described medicine is made up of following medicinal material by weight：
1 part of pomelo peel；2 parts of golden contracted payment；Parasitic 1 part of Calusena lansium；2 parts of Fermented Soybean；2 parts of eggplant root；2 parts of radish seed；1 part of the bighead atractylodes rhizome；River Even 1 part；1 part of radix bupleuri；1 part of tortoiseshell；1 part of the root of herbaceous peony；1 part of the root of large-flowered skullcap；1 part of isatis root；0.5 part of felwort；3 parts of the bark of eucommia.
The medicine of described big hepatitis B three sun for the treatment of, including following preparation process：
1) mix after the smalls above-mentioned a kind of bulk drug being respectively crushed into 0.3 sieve；
2) soak, amount of water is 3.5 times of the total amount of described bulk drug；
3), after soaking 1 hour, decoct；The amount of water decocting for the first time is 4 times of raw material gross weight, decocts 3 hours；After filtration, Add water in filter residue, the amount of water that second decocts is 5 times of raw material gross weight, decoct 2 hours；After filtration, add water in filter residue, the The amount of water of three decoctions is 3 times of raw material gross weight, decocts 1 hour.
4) extract decoction liquor, and be concentrated into 1.5 times of concentration, make gained pharmaceutical solutions.
Embodiment 2：
A kind of medicine treating hepatitis B great three positive is it is characterised in that described medicine is made up of following medicinal material by weight：
4 parts of pomelo peel；4 parts of golden contracted payment；Parasitic 4 parts of Calusena lansium；5 parts of Fermented Soybean；7 parts of eggplant root；5 parts of radish seed；6 parts of the bighead atractylodes rhizome；River Even 3 parts；4 parts of radix bupleuri；3 parts of tortoiseshell；4 parts of the root of herbaceous peony；4 parts of the root of large-flowered skullcap；5 parts of isatis root；3 parts of felwort；6 parts of the bark of eucommia.
Preparation method is with embodiment 1.
Embodiment 3：
A kind of medicine treating hepatitis B great three positive is it is characterised in that described medicine is made up of following medicinal material by weight：
3 parts of pomelo peel；3 parts of golden contracted payment；Parasitic 2 parts of Calusena lansium；3 parts of Fermented Soybean；5 parts of eggplant root；3 parts of radish seed；4 parts of the bighead atractylodes rhizome；River Even 2 parts；2 parts of radix bupleuri；2 parts of tortoiseshell；3 parts of the root of herbaceous peony；2 parts of the root of large-flowered skullcap；3 parts of isatis root；1.5 parts of felwort；4 parts of the bark of eucommia.
Preparation method is with embodiment 1.
2nd, application example：
1st, patient：Wang, female, Zhuang, 36 years old, Nanning people from Jiangnan District；
First visit：On March 20th, 16 medical history great three positive, 5 years, main suit：Weak, receive difference, vomiting, do not feel like eating, 16 days, because with Upper symptom is hepatitis B virus recurrence in local hospital diagnosis；
Liver function： AST；581,ALT；612, TBIL45, remaining normal；
Have a medical check-up：Young women, sclera is slight xanthochromia, skin no xanthochromia, there is liver palms no spider angioma, abdomen is soft, and liver spleen does not touch, Yu Zheng Often；
Treatment：Using 6 courses for the treatment of of this drug therapy；
Further consultation：On May 10th, 16, liver function is normal, five indices；First Five-Year Plan is positive, remaining normal, continual cure, patient's self-induction muscle power, Spirit takes an evident turn for the better diet can；
Examine again：On September 10th, 16, liver function is normal, five indexes of hepatitis b；Surface antibody turns sun, remaining normal, does not recur so far with anti-.
2nd, patient：Lee, man, 31 years old, peasant, Nanning Heng County Na Yangzhen people, hepatitis B great three positive, first visit January 27 in 2016 Day；
Patient's readme：Low-heat, vomiting, yellow five days of urine, weak, feed is then told, and is " acute icteric liver through hospital diagnosis Scorching "；
Have a medical check-up young man, acute liver disease face, sclera and skin moderate xanthochromia, no liver palms and spider angioma, abdomen is soft to have no ascites Disease, liver spleen does not touch；
Laboratory examination：Liver function ALT：120,TBIL：30, remaining normal；
Five indices：Great three positive B ultrasonic is pointed out：DHD；
Treatment：Using 6 courses for the treatment of of this drug therapy；
Further consultation five after 20 days：HBSAg：The positive, remaining：, liver function：Check in normal 2 months 25 days：Liver function：Normally, five indices： Anti- HBS：The positive, remaining：—；
Patient's self-induction spirit muscle power be normally, diet and two just can, stopped treatment, follow-up is not recurred so far.
The foregoing is only the preferred embodiment of invention, not in order to limit the present invention, all spirit in the present invention Within principle, any modification, equivalent substitution and improvement made etc., should be included within the scope of the present invention.

Claims (4)

1. a kind of medicine treating hepatitis B great three positive is it is characterised in that described medicine is made up of following medicinal material by weight：
Pomelo peel 1-4 part；Golden contracted payment 2-4 part；Calusena lansium parasitism 1-4 part；Fermented Soybean 2-5 part；Eggplant root 2-7 part；Radish seed 2-5 Part；Bighead atractylodes rhizome 1-6 part；River connects 1-3 part；Radix bupleuri 1-4 part；Tortoiseshell 1-3 part；Root of herbaceous peony 1-4 part；Root of large-flowered skullcap 1-4 part；Isatis root 1-5 part；Dragon Courage grass 0.5-3 part；Bark of eucommia 3-6 part.
2. the medicine for the treatment of hepatitis B great three positive according to claim 1 is it is characterised in that described medicine is by by weight Following medicinal material make：
3 parts of pomelo peel；3 parts of golden contracted payment；Parasitic 2 parts of Calusena lansium；3 parts of Fermented Soybean；5 parts of eggplant root；3 parts of radish seed；4 parts of the bighead atractylodes rhizome；River Even 2 parts；2 parts of radix bupleuri；2 parts of tortoiseshell；3 parts of the root of herbaceous peony；2 parts of the root of large-flowered skullcap；3 parts of isatis root；1.5 parts of felwort；4 parts of the bark of eucommia.
3. described in a kind of claim 1 and 2 treatment big hepatitis B three sun medicine preparation method it is characterised in that include with Lower preparation process：
1) mix after smalls above-mentioned raw materials medicine being respectively crushed into 0.3-0.4 sieve；
2) soak, amount of water is 3-4 times of the total amount of described bulk drug；
3), after soaking 1 hour, decoct；
4) extract decoction liquor, and be concentrated into 1-2 times of concentration, make gained pharmaceutical solutions.
4. the preparation method of the medicine for the treatment of hepatitis B great three positive according to claim 3 is it is characterised in that described step 3） Including：
The amount of water decocting for the first time is 4 times of raw material gross weight, decocts 3 hours；After filtration, add water in filter residue, decoct for second The amount of water boiling is 5 times of raw material gross weight, decocts 2 hours；After filtration, add water in filter residue, the amount of water that third time decocts is 3 times of raw material gross weight, decoct 1 hour.
CN201611026337.5A 2016-11-22 2016-11-22 Drug for treating HepatitisBHBeAg of HBV (hepatitis B virus) and preparation method of drug Pending CN106389655A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1907434A (en) * 2005-08-02 2007-02-07 深圳海王药业有限公司 Medicinal composition for treating hepatitis and preparation method thereof
CN101884764A (en) * 2009-05-15 2010-11-17 张春 Medicament for treating chronic hepatitis splenomegaly or cirrhosis splenomegaly
CN103948879A (en) * 2014-05-23 2014-07-30 周京壮 Traditional Chinese medicinal particles for treating viral hepatitis and preparation method thereof
CN104547876A (en) * 2013-10-16 2015-04-29 耿文杰 Traditional Chinese medicine for treating hepatitis B

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1907434A (en) * 2005-08-02 2007-02-07 深圳海王药业有限公司 Medicinal composition for treating hepatitis and preparation method thereof
CN101884764A (en) * 2009-05-15 2010-11-17 张春 Medicament for treating chronic hepatitis splenomegaly or cirrhosis splenomegaly
CN104547876A (en) * 2013-10-16 2015-04-29 耿文杰 Traditional Chinese medicine for treating hepatitis B
CN103948879A (en) * 2014-05-23 2014-07-30 周京壮 Traditional Chinese medicinal particles for treating viral hepatitis and preparation method thereof

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Application publication date: 20170215