CN106388977A - Bone restoration for large-area craniofacial bone defect - Google Patents
Bone restoration for large-area craniofacial bone defect Download PDFInfo
- Publication number
- CN106388977A CN106388977A CN201610740250.8A CN201610740250A CN106388977A CN 106388977 A CN106388977 A CN 106388977A CN 201610740250 A CN201610740250 A CN 201610740250A CN 106388977 A CN106388977 A CN 106388977A
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- Prior art keywords
- large area
- structural
- bone
- bone repair
- structural member
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2875—Skull or cranium
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- Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a bone restoration for large-area craniofacial bone defect. The bone restoration comprises a supporting structural piece, osteogenesis structural pieces and fixing nails, wherein the supporting structural piece comprises structural beams; a plurality of fixing holes are formed in the structural beams in a length direction; the fixing nails and the fixing holes are movably connected; the osteogenesis structural pieces comprise connecting holes and drainage holes; the connecting holes are formed in the upper ends of the drainage holes; and the supporting structural piece and the osteogenesis structural pieces are movably connected by virtue of the connecting holes. The types, sizes and assembling mode of the supporting structural piece and the osteogenesis structural pieces can be freely selected, so that the bone restoration has the advantages of being convenient to assemble, free to replace, simple to operate, convenient to cut, diverse in selections and the like, and the bone restoration can meet various demands; and in an operation, defect implantation can be implemented just by conducting plastic-forming on the supporting structural piece and then installing the different osteogenesis structural pieces on the supporting structural piece; therefore, in comparison with an existing customized craniofacial bone restoration applied to the clinical field, the manufacturing time of the bone restoration can be greatly shortened.
Description
Technical field
The invention belongs to technical field of biological material, especially relate to a kind of bone repair of large area Craniomaxilla defect.
Background technology
The bony union reparation of Craniomaxilla defect is exactly field of neurosurgery yet unresolved issue all the time.At present
Clinic, for cranium Maxillofacial defect, is typically covered using titanium net or titanium alloy, macromolecular material customization body carries out two kinds of sides such as filling up
Formula is treated.Clinical practice shows, both modes are treated cranium jaw face large defect and all be there are some problems：On the one hand,
When being repaired using titanium net, because metal material is excessively thin, hollow out has very high thermal conductivity, patient is not suitable for working under sunshine,
Simultaneously because cranium jaw face is in open shape body, patient is it is possible that the complication such as long-term headache, dizziness；On the other hand, use
Macromolecular material is carried out when cranium jaw face is repaired although macromolecular material, such as peek, lucite (polymethyl methacrylate) compare
Metal material having the advantages that chemical property is more stable, be difficult burn into plasticity, saturating x-ray, but exist customization time cycle length,
It is difficult to produce the dummy matching with patient's defect in time, and polymerisation when being prepared in situ is to clinician body
Harmful, need higher clinical manipulation skill, and have such problems as that material at a specified future date and bone interface merge, the problem of key is,
No matter repaired using that mode of this two mode, the bone reparation that all can not reach cranium Maxillofacial defect is it is impossible to realize cranium
The regeneration of jaw face, function only as recovering skull shape, prevent the effect that external force impacts to brain.
Content of the invention
The bone renovating material with bone formation performance and the implantable material phase with mechanical strength are assembled cooperation by the present invention
Technology path, designed by standardized module, osteogenesis function combined with mechanical support function, constitute one both may be used
To support the form maintaining cranium jaw, the body that defect becomes Bone Defect Repari can be carried out, the present invention has extremely strong practicality and flexibly again
Property, facilitate clinical manipulation.
For solving above-mentioned technical problem, the technical solution used in the present invention is：A kind of bone of large area Craniomaxilla defect
Dummy, including supporting structure, skeletonization structural member and fixing nail, described supporting structure includes structural beams, described structural beams
On be provided with several fixing holes along its length, described fixing nail is flexibly connected with fixing hole, and described skeletonization structural member includes
Connecting hole and conduction hole, described connecting hole is located at the upper end of described conduction hole, and described supporting structure is passed through with skeletonization structural member
Described connecting hole is flexibly connected.
Further, the structure of described supporting structure is plane or curved surface.
Further, described supporting structure mutually splices for several structural beams or is single structure beam.
Further, described supporting structure material is metal material or medical high polymer material, described metal material bag
Include titanium-base alloy, cobalt-base alloys or magnesium base alloy, described medical high polymer material is poly- friendship resin copolymer or poly- friendship resin copolymer
Blend.
Further, the structure of described skeletonization structural member is tetragonal body, hexahedron or ellipsoid.
Further, the main component of described skeletonization structural member consists of collagen, NCP and growth factor.
Further, described connecting hole is no less than 1.
Further, described connecting hole be shaped as trapezoidal, square or ellipse.
Further, described fixing hole is generally circular in shape or square.
Further, described fixation is followed closely as screw-type or intumescent.
Compared with prior art, the present invention has the advantage that with beneficial effect is：1st, doctor can be according to cranium Maxillofacial defect
Concrete condition, the type of unrestricted choice supporting structure and skeletonization structural member, size and group mode, have assemble conveniently,
Arbitrarily replacings, simple, convenient cutting, selection is various, the advantages of meet different demands, skeletonization structural member therein is prefabricated
Complete, so, need only to carry out plasticity to supporting structure in operation, then different skeletonization structural members is installed to and props up
Implantation at defect can be carried out on support structure part.Therefore, compared with the customization cranio-maxillofacial restorator of application in present clinic, greatly
The earth shortens Production Time, it is to avoid the problem that patient waits as long for.2nd, by two kinds of biologies by way of assembling coordinates
Combination of materials is applied, and can meet the requirement that support, covering and the filling of needs are repaired in cranium jaw face, again can be in the work of osteogenic materials
With lower guiding Bone Defect Repari, realize osteanagenesis truly.
Brief description
Fig. 1 is a kind of the whole of the bone repair of large area Craniomaxilla defect that supporting structure of the present invention is planar structure
Body structural representation.
Fig. 2 is a kind of the whole of the bone repair of large area Craniomaxilla defect that supporting structure of the present invention is curved-surface structure
Body structural representation.
Fig. 3 is the present invention by a kind of structural representation of embodiment of the supporting structure of multiple structural beams mutually splicing.
Fig. 4 is a kind of structural representation of embodiment of the supporting structure that the present invention is made up of single structure beam.
Fig. 5 is a kind of large area Craniomaxilla defect of supporting structure of the present invention and square skeletonization structural member composition
The structural representation of bone repair.
Fig. 6 is a kind of large area Craniomaxilla defect of supporting structure of the present invention and hexahedron skeletonization structural member composition
The structural representation of bone repair.
Fig. 7 is a kind of large area Craniomaxilla defect of supporting structure of the present invention and ellipsoid skeletonization structural member composition
The structural representation of bone repair.
Fig. 8 is a kind of large area of the skeletonization structural member composition that supporting structure of the present invention is generally aligned in the same plane with connecting hole
The structural representation of the bone repair of Craniomaxilla defect.
Fig. 9 is a kind of large area cranium jaw that supporting structure of the present invention is formed with the skeletonization structural member with two connecting holes
The structural representation of the bone repair of facial bone defect
In figure：1- supporting structure；2- skeletonization structural member；The fixing nail of 3-；4- structural beams；5- fixing hole；6- connecting hole；7-
Conduction hole.
Specific embodiment
Below in conjunction with the accompanying drawings the specific embodiment of the present invention is elaborated.
As shown in Figure 1 and Figure 2, a kind of bone repair of large area Craniomaxilla defect, including supporting structure 1, skeletonization knot
Component 2 and fixing nail 3, described supporting structure 1 includes structural beams 4, described structural beams 4 is provided with several along its length
Fixing hole 5, described fixing nail 3 is flexibly connected with fixing hole 5, and described skeletonization structural member 2 includes connecting hole 6 and conduction hole 7, described
Connecting hole 6 is located at the upper end of described conduction hole 7, and described supporting structure 1 and skeletonization structural member 2 pass through the activity of described connecting hole 6
Connect, supporting structure 1 by plug-in card, inlay by way of bone structure part 2, the knot of supporting structure 1 are connected into by connecting hole 6
Structure is plane or curved surface, can better conform to the feature of patient bone defect, have good matching performance.
As shown in Figure 3, Figure 4, described supporting structure 1 mutually splices for several structural beams 4 or is single structure beam 4,
Between structural beams 4, the minimal structure of composition is shaped as polygon, is preferred with quadrangle, and the area of minimal structure shape exists
0.5cm2-100cm2, the cross sectional shape of single structure beam 4 is polygon or ellipse, with rectangle and trapezoidal for preferred, simultaneously
The area in structural beams 4 section is in 0.2mm2-25mm2Between, doctor can freely select structural beams 4 according to the situation of patient
Size and combination, have the advantages that to assemble convenience, arbitrarily replacing, simple, convenient cutting, significantly shorten making
Time, it is to avoid the problem that patient waits as long for.
Further, described supporting structure 1 material is metal material or medical high polymer material, described metal material bag
Include titanium-base alloy, cobalt-base alloys or magnesium base alloy, described medical high polymer material is poly- friendship resin copolymer or poly- friendship resin copolymer
Blend, titanium-base alloy, cobalt-base alloys and magnesium base alloy all have good biocompatibility with human body, are by megastage bone
The good material of defect repair selects, and magnesium base alloy can also be degraded by human body；Described poly- friendship resin copolymer is
PGA or poly- third friendship fat, gather and hand over resin copolymer blend to be that PGA third hands over fat, the support knot of medical macromolecular materials
Component 1, while playing a supporting role, also can be degraded by human body over time in human body internal memory, mitigates patients head
Pressure.
As shown in Figure 5-Figure 8, the structure of described skeletonization structural member 2 is tetragonal body, hexahedron or ellipsoid, skeletonization structural member
Connecting hole 6 on 2 can be through two faces being parallel to each other or be through a face, it is possible to use the support of different structure
Structural member 1 is connected by plug-in card or by way of inlaying with skeletonization structural member, and the large area cranio-maxillofacial of composition different structure lacks
The bone repair damaging, during the bone defect healing to patient, the situation according to patient can select to be suitable for the treatment of patient
Scheme, and these combining forms are easy to make quick, decrease fabrication cycle.
Further, the main component of described skeletonization structural member 2 consists of collagen, calcium salt and growth factor, has
Promote well the ability of osteanagenesis, wherein collagen is I type and/or type III collagen, calcium salt be hydroxyapatite or
Calcium phosphate, growth factor be Nell-1 albumen, therefore can as the material of skeletonization structural member 2 have homogeneous allogenic bone, bone- xenograft,
Allogeneic decalcified bone matrix or bone- xenograft decalcified bone matrix etc..
Further, described connecting hole 6 is no less than 1, in order to preferably be fixed to dummy, becomes bone structure
One or more connecting holes 6 can be arranged on part 2, as shown in figure 9, have the oval skeletonization structural member 2 of two connecting holes 6 with
The bone repair of the large area Craniomaxilla defect that two structural beams 4 are formed by way of inlaying, the skeletonization knot of various structures
Component 2 is that the making of bone repair provides more combining forms, meets different demands.
Further, described connecting hole 6 be shaped as trapezoidal, square or ellipse, the area of section of connecting hole 6 exists
0.2mm2-25mm2Between, it is mutually matched with the size of structural beams 4.
Further, described fixing hole 5 is generally circular in shape or square, and aperture is between 0.5mm-5mm.
Further, described fixing nail 3 is screw-type or intumescent, and the diameter of fixing nail 3 is between 0.5mm-5mm, high
Degree is between 2mm-10mm.
Above one embodiment of the present of invention is described in detail, but described content has been only the preferable enforcement of the present invention
Example is it is impossible to be considered the practical range for limiting the present invention.All impartial changes made according to the present patent application scope and improvement
Deng all should still belong within the patent covering scope of the present invention.
Claims (10)
1. a kind of bone repair of large area Craniomaxilla defect it is characterised in that：Including supporting structure (1), become bone structure
Part (2) and fixing nail (3), described supporting structure (1) includes structural beams (4), described structural beams (4) is arranged along its length
There are several fixing holes (5), described fixing nail (3) is flexibly connected with fixing hole (5), and described skeletonization structural member (2) includes connecting
Hole (6) and conduction hole (7), described connecting hole (6) is located at upper end, described supporting structure (1) and the skeletonization of described conduction hole (7)
Structural member (2) passes through described connecting hole (6) and is flexibly connected.
2. a kind of large area Craniomaxilla defect according to claim 1 bone repair it is characterised in that：Described support
The structure of structural member (1) is plane or curved surface.
3. a kind of large area Craniomaxilla defect according to claim 2 bone repair it is characterised in that：Described support
Structural member (1) is several structural beams (4) mutually splicing or is single structure beam (4).
4. a kind of large area Craniomaxilla defect according to claim 3 bone repair it is characterised in that：Described support
Structural member (1) material is metal material or medical high polymer material, and described metal material includes titanium-base alloy, cobalt-base alloys or magnesium
Based alloy, described medical high polymer material is poly- friendship resin copolymer or poly- friendship resin copolymer blend.
5. a kind of large area Craniomaxilla defect according to claim 1 bone repair it is characterised in that：Described skeletonization
The structure of structural member (2) is tetragonal body, hexahedron or ellipsoid.
6. a kind of large area Craniomaxilla defect according to claim 5 bone repair it is characterised in that：Described skeletonization
The main component of structural member (2) consists of collagen, NCP and growth factor.
7. a kind of large area Craniomaxilla defect according to claim 1 bone repair it is characterised in that：Described connection
Hole (6) is no less than 1.
8. a kind of large area Craniomaxilla defect according to claim 1 or 7 bone repair it is characterised in that：Described
Connecting hole (6) be shaped as trapezoidal, square or ellipse.
9. a kind of large area Craniomaxilla defect according to claim 1 bone repair it is characterised in that：Described fixation
Hole (5) generally circular in shape or square.
10. a kind of large area Craniomaxilla defect according to claim 1 bone repair it is characterised in that：Described solid
Fixed nail (3) is screw-type or intumescent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610740250.8A CN106388977B (en) | 2016-08-26 | 2016-08-26 | A kind of bone repair of large area Craniomaxilla defect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610740250.8A CN106388977B (en) | 2016-08-26 | 2016-08-26 | A kind of bone repair of large area Craniomaxilla defect |
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| Publication Number | Publication Date |
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| CN106388977A true CN106388977A (en) | 2017-02-15 |
| CN106388977B CN106388977B (en) | 2018-11-30 |
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| CN201610740250.8A Active CN106388977B (en) | 2016-08-26 | 2016-08-26 | A kind of bone repair of large area Craniomaxilla defect |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112472334A (en) * | 2020-11-25 | 2021-03-12 | 广州市弘健生物医用制品科技有限公司 | A supporting structure for alveolar bone is rebuild |
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| US20040210222A1 (en) * | 2001-02-28 | 2004-10-21 | Angelucci Christopher M. | Laminoplasty plates and methods of use |
| DE102009008688A1 (en) * | 2009-02-06 | 2010-08-19 | Aesculap Ag | Closing implant i.e. craniotomy closure, for closing large cranial bone openings in skull of patient, has closure elements separated from each other and directly or indirectly movable relative to each other |
| CN103857351A (en) * | 2011-08-22 | 2014-06-11 | 奥斯设计公司 | Implants and methods of using the implants to fill holes in bone tissue |
| CN203662943U (en) * | 2013-11-28 | 2014-06-25 | 北京奥精医药科技有限公司 | Bionic implant for skull repairing |
| US20140257325A1 (en) * | 2013-03-10 | 2014-09-11 | Neuropace, Inc. | Recessed Burr Hole Covers and Methods for Using the Same |
| CN204971712U (en) * | 2015-07-03 | 2016-01-20 | 天津市赛宁生物工程技术有限公司 | Body is implanted in damaged restoration of skull with blood drainage hole |
-
2016
- 2016-08-26 CN CN201610740250.8A patent/CN106388977B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040210222A1 (en) * | 2001-02-28 | 2004-10-21 | Angelucci Christopher M. | Laminoplasty plates and methods of use |
| DE102009008688A1 (en) * | 2009-02-06 | 2010-08-19 | Aesculap Ag | Closing implant i.e. craniotomy closure, for closing large cranial bone openings in skull of patient, has closure elements separated from each other and directly or indirectly movable relative to each other |
| CN103857351A (en) * | 2011-08-22 | 2014-06-11 | 奥斯设计公司 | Implants and methods of using the implants to fill holes in bone tissue |
| US20140257325A1 (en) * | 2013-03-10 | 2014-09-11 | Neuropace, Inc. | Recessed Burr Hole Covers and Methods for Using the Same |
| CN203662943U (en) * | 2013-11-28 | 2014-06-25 | 北京奥精医药科技有限公司 | Bionic implant for skull repairing |
| CN204971712U (en) * | 2015-07-03 | 2016-01-20 | 天津市赛宁生物工程技术有限公司 | Body is implanted in damaged restoration of skull with blood drainage hole |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112472334A (en) * | 2020-11-25 | 2021-03-12 | 广州市弘健生物医用制品科技有限公司 | A supporting structure for alveolar bone is rebuild |
| CN112472334B (en) * | 2020-11-25 | 2021-10-29 | 广州市弘健生物医用制品科技有限公司 | A supporting structure for alveolar bone is rebuild |
| CN113813063A (en) * | 2020-11-25 | 2021-12-21 | 广州市弘健生物医用制品科技有限公司 | A supporting structure for atrophy alveolar bone is restoreed |
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| Publication number | Publication date |
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| CN106388977B (en) | 2018-11-30 |
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