CN106387597A - Instant honeysuckle flower solid beverage and preparation method thereof - Google Patents
Instant honeysuckle flower solid beverage and preparation method thereof Download PDFInfo
- Publication number
- CN106387597A CN106387597A CN201610799781.4A CN201610799781A CN106387597A CN 106387597 A CN106387597 A CN 106387597A CN 201610799781 A CN201610799781 A CN 201610799781A CN 106387597 A CN106387597 A CN 106387597A
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- Prior art keywords
- flos lonicerae
- solid beverage
- instant
- lactose
- mass ratio
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- 235000013361 beverage Nutrition 0.000 title claims abstract description 76
- 239000007787 solid Substances 0.000 title claims abstract description 74
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 241000205585 Aquilegia canadensis Species 0.000 title abstract 11
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 56
- 239000008101 lactose Substances 0.000 claims abstract description 56
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 39
- 239000000843 powder Substances 0.000 claims abstract description 39
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000000284 extract Substances 0.000 claims abstract description 7
- 239000000080 wetting agent Substances 0.000 claims abstract description 6
- 241000628997 Flos Species 0.000 claims description 116
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 75
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 31
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims description 29
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims description 29
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims description 29
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims description 29
- 229940074393 chlorogenic acid Drugs 0.000 claims description 29
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims description 29
- 235000001368 chlorogenic acid Nutrition 0.000 claims description 29
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims description 29
- 238000001514 detection method Methods 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 17
- 238000012360 testing method Methods 0.000 claims description 16
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 15
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 15
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- 239000012071 phase Substances 0.000 claims description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 8
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 7
- 229960004756 ethanol Drugs 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 6
- 239000007791 liquid phase Substances 0.000 claims description 5
- 239000007779 soft material Substances 0.000 claims description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 4
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 239000004005 microsphere Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 238000000825 ultraviolet detection Methods 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 2
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 8
- 230000007547 defect Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 3
- 230000004060 metabolic process Effects 0.000 abstract description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 15
- 238000012216 screening Methods 0.000 description 10
- 230000008569 process Effects 0.000 description 7
- 238000001035 drying Methods 0.000 description 6
- 239000003085 diluting agent Substances 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 239000003513 alkali Substances 0.000 description 4
- 238000005453 pelletization Methods 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000012372 quality testing Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- SRWKSFRBHIWJSD-UHFFFAOYSA-N 6-cyclohexylhexan-1-ol Chemical compound OCCCCCCC1CCCCC1 SRWKSFRBHIWJSD-UHFFFAOYSA-N 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000589902 Leptospira Species 0.000 description 1
- 241000245240 Lonicera Species 0.000 description 1
- 241001570521 Lonicera periclymenum Species 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses an instant honeysuckle flower solid beverage and a preparation method thereof. The instant honeysuckle flower solid beverage comprises the following components in percentage by mass: 40% of honeysuckle flower extract powder, 20-40% of a disintegrating agent and 20-40% of lactose; the instant honeysuckle flower solid beverage also comprises a 2% polyvinylpyrrolidone (PVP) ethanol solution as a wetting agent; and the total mass percentage of the instant honeysuckle flower solid beverage is 100%. On basis of traditional Chinese medicine theories and in combination with the newest frontier technologies, the essence parts are extracted and rationally proportioned according to the preparation method so as to prepare the instant honeysuckle flower solid beverage; thus, the prepared instant honeysuckle flower solid beverage has the functions of promoting metabolism and improving human body immunity. The instant honeysuckle flower solid beverage is rapid to dissolve and convenient to carry, and can be directly drunk after being brewed. Therefore, the instant honeysuckle flower solid beverage overcomes the defects of honeysuckle flower application, including limitations and difficult absorption, so as to greatly facilitate the consumers.
Description
Technical field
The invention belongs to technical field of beverage, more particularly, to a kind of Flos Lonicerae instant solid beverage and preparation method thereof.
Background technology
Flos Lonicerae contains cyclohexanhexanol, flavonoid, inositol, Saponin and tannin etc., has broad-spectrum antibacterial action, to golden yellow Portugal
The various pathogens such as grape coccus, dysentery bacterium all have stronger inhibitory action, to leptospira, influenza virus and cause a disease mould
The multiple pathogenic microorganisms such as bacterium also have inhibitory action.Additionally, Flos Lonicerae also has obvious antiinflammatory and refrigeration function, honeysuckle flower water
And steeping in wine liquid has obvious lethal effect to tentative tumor cell.The flower of Flos Lonicerae, leaf through distillation be obtained distillate
The Liquor Flos Lonicerae Distillata.Summer makes beverage with it, and not only sweet flavor is good to eat, but also has the work(of good clearing away summer-heat.
Flos Lonicerae nourishing instant solid beverage, is that science is joined in Chinese medicine and pharmacy theoretical combining with modern nutriology research
Than, it is made with modern science and technology, easy to carry, directly take after mixing it with water, facilitate consumer.
Content of the invention
It is an object of the invention to provide a kind of Flos Lonicerae instant solid beverage and preparation method thereof is it is intended to solve following main
Want problem：(1) the prescription composition of rapidly dissolving tablet, obtains clear and bright liquid beverage after being dissolved in water；(2) preparation process is simple, and prepare
During will not sticking；(3) rapidly dissolving tablet prepared is up-to-standard；(4) easy to carry it is easy to storage.
The present invention is achieved in that a kind of Flos Lonicerae instant solid beverage, this each component of Flos Lonicerae instant solid beverage
It is made up of Flos Lonicerae extractum powder 40%, disintegrating agent 20%-40%, Lactose 20-40% in mass ratio, Flos Lonicerae fast dissolving solid is drunk
Material gross mass ratio is 100%.
Further, described disintegrating agent component is made up of sodium bicarbonate, citric acid, described sodium bicarbonate and citric acid mass ratio
Example be：Sodium bicarbonate：Citric acid=1-1.5:1.
Further, when in Flos Lonicerae instant solid beverage component, Lactose mass ratio is 20%, Flos Lonicerae instant solid beverage
In component, preferred version one is in mass ratio：
Flos Lonicerae extractum powder is 40%, Lactose 20%, disintegrating agent 40%.
Further, when in Flos Lonicerae instant solid beverage component, Lactose mass ratio is 25%, Flos Lonicerae instant solid beverage
In component, preferred version two is in mass ratio：
Flos Lonicerae extractum powder 40%, Lactose 25%, disintegrating agent 35%.
Further, when Flos Lonicerae instant solid beverage component Lactose mass ratio is in 30%, Flos Lonicerae instant solid beverage
In component, preferred version three is in mass ratio:
Flos Lonicerae extractum powder 40%, Lactose 30%, disintegrating agent 30%.
Further, when in Flos Lonicerae instant solid beverage component, Lactose mass ratio is 35%, Flos Lonicerae instant solid beverage
In component, preferred version four is in mass ratio:
Flos Lonicerae extractum powder 40%, Lactose 35%, disintegrating agent 25%.
Further, when in Flos Lonicerae instant solid beverage component, Lactose mass ratio is 40%, Flos Lonicerae instant solid beverage
In component, preferred version five is in mass ratio:
Flos Lonicerae extractum powder 40%, Lactose 40%, disintegrating agent 20%.
A kind of preparation method of Flos Lonicerae instant solid beverage as claimed in claim 1, this Flos Lonicerae instant solid beverage
Preparation method include：
Flos Lonicerae extractum powder 40%, disintegrating agent 20%-40%, Lactose 20-40% in mass ratio, the powder to after cooling and solidifying
Broken sodium bicarbonate adds Flos Lonicerae dried powder and pre-dry Lactose, and Flos Lonicerae instant solid beverage gross mass ratio is
100%, and sodium bicarbonate in mass ratio：Citric acid=1-1.5:1 addition adds citric acid, mixing；
Make wetting agent soft material with 2% PVP ethanol, cross 14 mesh sieves and pelletize, 40 DEG C are dried 4h, after granulate,
Tabletting.
Make wetting agent soft material with 2% PVP (PVP) ethanol, cross 14 mesh sieves and pelletize, 40 DEG C are dried 4h, whole
Grain, tabletting.
The impact that Flos Lonicerae instant solid beverage after tabletting also needs to carry out the mensure of chlorogenic acid, adjuvant measures to chlorogenic acid
In detection, the instant tablet recipe of Flos Lonicerae, the hygroscopicity of each raw material detects, uniformity of dosage units detects, rapidly dissolving tablet tablet weight variation detects,
Rapidly dissolving tablet detection disintegration；
The assay method of chlorogenic acid is：
With 100 μ g mL-1Chlorogenic acid as storing solution, take a certain amount of mobile phase to be diluted to 0.5 respectively, 1,2,3,4,5,
6、7μg·mL-1；
Chromatographic column：GeminiI-NX-C18(4.6mm×250mm,5μm)；
Mobile phase, acetonitrile：0.2% phosphoric acid=20:80；
Flow velocity 1.0ml/min；
Sample size 20 μ l, 327nm ultraviolet detection,
X is chlorogenic acid concentration (mg/ml), and Y is peak area, and calculates the regression equation of gained standard curve；
Adjuvant to the impact detection method that chlorogenic acid measures is：
By extract powder, Lactose, sodium bicarbonate, citric acid, the order that 2%PVP dehydrated alcohol is pelletized, use 50% ethanol successively
It is diluted to finite concentration, by above-mentioned efficient liquid phase method, sample introduction 20 μ l, 327nm detect respectively, bent with peak area and above-mentioned standard
Line computation chlorogenic acid content, is repeated 3 times, and averages；
In the instant tablet recipe of Flos Lonicerae, the hygroscopicity detection method of each raw material is：
Take a certain amount of sample, accurately weighed (W0), be positioned over 25 DEG C, relative humidity be in 75% saturation NaCl solution,
Take out after 2h, 3h, 4h, accurately weighed microspheres quality (W1),
It is calculated as follows hydroscopicity：Hydroscopicity=[(W1-W0)/W0] × 100%；
Uniformity of dosage units detection method is：
Take test sample 10, measure the relative amount X that every is 100 with labelled amount respectively, ask its average X and standard deviation S
And the absolute value A of the difference of labelled amount and average,
A=100-X)；
If A+1.80S≤15.0, that is, the uniformity of dosage units of test sample meets regulation；If A+S>15.0, then against regulation；
If A+1.80S>15.0, and A+S≤15.0, then should separately take 20 (individual) retrials；According to first, retrial result, calculate 30 equal
The absolute value A of the difference of value X, standard deviation S and labelled amount and average；
If A+1.45S≤15.0, that is, the uniformity of dosage units of test sample meets regulation；If A+1.45S>15.0, then do not meet
Regulation, calculates labelled amount as 7.2mg with chlorogenic acid content；
Rapidly dissolving tablet tablet weight variation detection method is：
Take test sample 20, accurately weighed gross mass, after trying to achieve average piece weight, then the quality of accurately weighed every respectively；
Every tablet quality is compared with average piece heavy phase, and the tablet beyond mass discrepancy must not be more than 2, and must not have 1 overrun 1
Times；
Rapidly dissolving tablet detection method disintegration is：
Take 1, put in 250ml beaker, in beaker, fill 200ml water, water temperature is 15 DEG C -25 DEG C, have many bubbles to release, when
When gas around tablet or fragment stops effusion, tablet dissolved or be dispersed in water, the granule of no gathering is left；With method inspection
6, each all should disintegrate in 5 minutes；If any 1 can not disintegrate completely, should separately take 6 retrials, all should conformance with standard.
The present invention according to Traditional Chinese medical theory on existing experiment basis, optimization formulation, not soluble-containing starch in prescription
The rapidly dissolving tablet of preparation is clear and bright after being dissolved in water, and overcoming can be in muddy shape containing soluble starch in prescription；Improve bonding
Agent PVP (PVP) concentration of alcohol to 2% so as to get rapidly dissolving tablet outward appearance more attractive in appearance；Disintegrate is passed through in this experiment
In agent, the ratio screening of sodium bicarbonate and citric acid, thus simplifying experiment, need not use PEG6000 encapsulated sodium bicarbonate, equally making
The rapidly dissolving tablet obtaining reaches quality standards requirement；This research on the basis of existing technology, simplifies preparation process, is obtained and meets matter
The rapidly dissolving tablet that amount standard requires, is easy to carry about with one, in conjunction with up-to-date frontier science and technology, extracts essential part therein through rational proportion system
Form, have the function of the body immunity that enhances metabolism, improves.The dissolving of Flos Lonicerae solid beverage is quick, easy to carry, directly
Connect and take after mixing it with water, the application overcoming Flos Lonicerae has certain limitation and the difficult defect absorbing, and greatly facilitates consumer.
Brief description
Fig. 1 is the preparation method flow chart of Flos Lonicerae instant solid beverage provided in an embodiment of the present invention.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to
Limit the present invention.
Below in conjunction with the accompanying drawings the present invention is elaborated.
A kind of Flos Lonicerae instant solid beverage, this each component of Flos Lonicerae instant solid beverage is in mass ratio by Flos Lonicerae extractum
Powder 40%, disintegrating agent 20%-40%, Lactose 20%-40% form, and Flos Lonicerae instant solid beverage gross mass ratio is
100%.
Described disintegrating agent component is made up of sodium bicarbonate, citric acid, and described sodium bicarbonate and citric acid mass ratio are：Carbon
Sour hydrogen sodium：Citric acid=1-1.5:1.
When in Flos Lonicerae instant solid beverage component, Lactose mass ratio is 20%, press in Flos Lonicerae instant solid beverage component
Quality than preferred version one is：
Flos Lonicerae extractum powder is 40%, Lactose 20%, disintegrating agent 40%.
When in Flos Lonicerae instant solid beverage component, Lactose mass ratio is 25%, press in Flos Lonicerae instant solid beverage component
Quality than preferred version two is：
Flos Lonicerae extractum powder 40%, Lactose 25%, disintegrating agent 35%.
When in Flos Lonicerae instant solid beverage component, Lactose mass ratio is 30%, press in Flos Lonicerae instant solid beverage component
Quality than preferred version three is:
Flos Lonicerae extractum powder 40%, Lactose 30%, disintegrating agent 30%.
When in Flos Lonicerae instant solid beverage component, soluble starch mass ratio is 35%, Flos Lonicerae instant solid beverage group
In point, preferred version four in mass ratio is:
Flos Lonicerae extractum powder 40%, Lactose 35%, disintegrating agent 25%.
When in Flos Lonicerae instant solid beverage component, soluble starch mass ratio is 40%, Flos Lonicerae instant solid beverage group
In point, preferred version four in mass ratio is:
Flos Lonicerae extractum powder 40%, Lactose 40%, disintegrating agent 20%.
As shown in Figure 1：A kind of preparation method of Flos Lonicerae instant solid beverage as claimed in claim 1, this Flos Lonicerae speed
The preparation method of molten solid beverage includes：
S101：Weigh required Flos Lonicerae dried powder, Lactose, sodium bicarbonate, citric acid puts into 40 DEG C of baking ovens, dried
Night, standby；
S102：Flos Lonicerae extractum powder 40%, disintegrating agent 20%-40%, Lactose 20%-40% in mass ratio, in advance
The sodium bicarbonate being dried adds Flos Lonicerae dried powder and pre-dry Lactose, Flos Lonicerae instant solid beverage gross mass ratio
For 100%, and sodium bicarbonate in mass ratio：Citric acid=1-1.5:1 addition adds citric acid, mixing；
S103：Make wetting agent soft material with 2% PVP (PVP) ethanol, cross 14 mesh sieves and pelletize, 40 DEG C of dryings
4h, granulate, tabletting.
The impact that Flos Lonicerae instant solid beverage after tabletting also needs to carry out the mensure of chlorogenic acid, adjuvant measures to chlorogenic acid
In detection, the instant tablet recipe of Flos Lonicerae, the hygroscopicity of each raw material detects, uniformity of dosage units detects, rapidly dissolving tablet tablet weight variation detects,
Rapidly dissolving tablet detection disintegration；
The assay method of chlorogenic acid is：
With 100 μ g mL-1Chlorogenic acid as storing solution, take a certain amount of mobile phase to be diluted to 0.5 respectively, 1,2,3,4,5,
6、7μg·mL-1；
Chromatographic column：GeminiI-NX-C18(4.6mm×250mm,5μm)；
Mobile phase, acetonitrile：0.2% phosphoric acid=20:80；
Flow velocity 1.0ml/min；
Sample size 20 μ l, 327nm ultraviolet detection,
X is chlorogenic acid concentration (mg/ml), and Y is peak area, and calculates the regression equation of gained standard curve；
Adjuvant to the impact detection method that chlorogenic acid measures is：
By extract powder, Lactose, sodium bicarbonate, citric acid, the order that 2%PVP dehydrated alcohol is pelletized, efficient liquid phase survey successively
Determine chlorogenic acid content, be repeated 3 times, average；
In the instant tablet recipe of Flos Lonicerae, the hygroscopicity detection method of each raw material is：
Take a certain amount of sample, accurately weighed (W0), be positioned over 25 DEG C, relative humidity be in 75% saturation NaCl solution,
Take out after 2h, 3h, 4h, accurately weighed microspheres quality (W1),
It is calculated as follows hydroscopicity：Hydroscopicity=[(W1-W0)/W0] × 100%；
Uniformity of dosage units detection method is：
Take test sample 10, measure the relative amount X that every is 100 with labelled amount respectively, ask its average X and standard deviation S
And the absolute value A of the difference of labelled amount and average,
A=100-X)；
If A+1.80S≤15.0, that is, the uniformity of dosage units of test sample meets regulation；If A+S>15.0, then against regulation；
If A+1.80S>15.0, and A+S≤15.0, then should separately take 20 (individual) retrials；According to first, retrial result, calculate 30 equal
The absolute value A of the difference of value X, standard deviation S and labelled amount and average；
If A+1.45S≤15.0, that is, the uniformity of dosage units of test sample meets regulation；If A+1.45S>15.0, then do not meet
Regulation, calculates labelled amount as 7.2mg with chlorogenic acid content；
Rapidly dissolving tablet tablet weight variation detection method is：
Take test sample 20, accurately weighed gross mass, after trying to achieve average piece weight, then the quality of accurately weighed every respectively；
Every tablet quality is compared with average piece heavy phase, and the tablet beyond mass discrepancy must not be more than 2, and must not have 1 overrun 1
Times；
Rapidly dissolving tablet detection method disintegration is：
Take 1, put in 250ml beaker, in beaker, fill 200ml water, water temperature is 15 DEG C -25 DEG C, have many bubbles to release, when
When gas around tablet or fragment stops effusion, tablet dissolved or be dispersed in water, the granule of no gathering is left；With method inspection
6, each all should disintegrate in 5 minutes；If any 1 can not disintegrate completely, should separately take 6 retrials, all should conformance with standard.
The present invention, according to Traditional Chinese medical theory, in conjunction with up-to-date frontier science and technology, extracts essential part therein through Reasonable
Ratio is made, and has the function of the body immunity that enhances metabolism, improves.The dissolving of Flos Lonicerae solid beverage is quick, the side of carrying
Just, directly take after mixing it with water, the application overcoming Flos Lonicerae has certain limitation and the difficult defect absorbing, and greatly facilitates consumer.
Below in conjunction with the accompanying drawings and specific embodiment is further described to the application principle of the present invention.
1. the mensure of chlorogenic acid
With 100 μ g mL-1Chlorogenic acid as storing solution, take a certain amount of mobile phase to be diluted to 0.5 respectively, 1,2,3,4,5,
6、7μg·mL-1, chromatographic column：GeminiI-NX-C18 (4.6mm × 250mm, 5 μm), mobile phase：Acetonitrile：0.2% phosphoric acid (20:
80), flow velocity 1.0ml/min sample size 20 μ l, 327nm ultraviolet detection, X is chlorogenic acid concentration (mg/ml), and Y is peak area, and counts
Calculate the regression equation of gained standard curve.
2. Flos Lonicerae rapidly dissolving tablet prescription screening
2.1 rapidly dissolving tablet diluent are that Lactose each prescription ratio is screened
Prescription 1：Flos Lonicerae extractum powder 40%, disintegrating agent 40%, Lactose 20%；
Prescription 2：Flos Lonicerae extractum powder 40%, disintegrating agent 35%, Lactose 25%；
Prescription 3：Flos Lonicerae extractum powder 40%, disintegrating agent 30%, Lactose 30%；
Prescription 4：Flos Lonicerae extractum powder 40%, disintegrating agent 25%, Lactose 35%；
Prescription 5：Flos Lonicerae extractum powder 40%, disintegrating agent 20%, Lactose 40%；
The prescription screening of 2.2 rapidly dissolving tablet disintegrating agents
2.2.1 disintegrating agent alkali and the prescription ratio of acid are screened
By prescription：Flos Lonicerae extractum powder 40%, disintegrating agent 30%, Lactose 30%, screening alkali and sour ratio 1：1、
1.2:1、1.3:1、1.5:1.
2.2.2 rapidly dissolving tablet disintegrating agent basic component ratio screening
Disintegrating agent：Sodium bicarbonate：Citric acid=1.3：1；
3. rapidly dissolving tablet preparation technology
3.1 rapidly dissolving tablet pelletization screenings drying time
By prescription：Flos Lonicerae extractum powder 40%, disintegrating agent 30%, Lactose 30%；
Disintegrating agent：Sodium bicarbonate：Citric acid=1.3：1；
After pelletizing as stated above, it is separately dried 2h, 3h, 4h, 6h, 8h.Sticking situation and system relatively in tableting processes
Obtain the screening of rapidly dissolving tablet situation.
3.2 rapidly dissolving tablet are pelletized, tablet forming technique
Weigh recipe quantity Flos Lonicerae dried powder, Lactose, ammonium hydrogen carbonate eh, citric acid, put into 40 DEG C of oven dried overnight
Standby, take out and be cooled to room temperature, mixing, make wetting agent soft material with 2% PVP (PVP) ethanol, cross 14 mesh sieve series
Grain, 40 DEG C are dried 4h, granulate, tabletting.Character after the dissolubility in water and dissolving for the rapidly dissolving tablet relatively prepared.
4. Flos Lonicerae rapidly dissolving tablet quality testing
The impact that 4.1 adjuvants measure to chlorogenic acid
By extract powder, Lactose, sodium bicarbonate, citric acid, the order that 2%PVP dehydrated alcohol is pelletized, efficient liquid phase survey successively
Determine chlorogenic acid content, be repeated 3 times, average.
The hygroscopicity detection of each raw material in the instant tablet recipe of 4.2 Flos Loniceraes
Take a certain amount of sample, accurately weighed (W0), be positioned over 25 DEG C, relative humidity be in 75% saturation NaCl solution,
Take out after 2h, 3h, 4h, accurately weighed microspheres quality (W1), be calculated as follows hydroscopicity：Hydroscopicity=[(W1-W0)/W0] ×
100%.
4.3 uniformity of dosage units
Take test sample 10 with reference to official method, according to the method for regulation under each medicine item, measure every respectively with labelled amount
Relative amount X for 100, seeks the absolute value A (A=100-X) of its average X and standard deviation S and labelled amount and the difference of average；
As A+1.80S≤15.0, that is, the uniformity of dosage units of test sample meets regulation；If A+S>15.0, then against regulation；If A+
1.80S>15.0, and A+S≤15.0, then should separately take 20 (individual) retrials.According to first, retrial result, calculate the equal of 30 (individual)
The absolute value A of the difference of value X, standard deviation S and labelled amount and average；As A+1.45S≤15.0, i.e. the uniformity of dosage units symbol of test sample
Close regulation；If A+1.45S>15.0, then against regulation.(labelled amount is calculated as 7.2mg with chlorogenic acid content)
4.4 rapidly dissolving tablet tablet weight variations
With reference to 2010 editions pharmacopeia assay methods：Take test sample 20, accurately weighed gross mass, after trying to achieve average piece weight, then
The quality of accurately weighed every respectively.Every tablet quality is compared with average piece heavy phase, specifies by table, beyond the tablet of mass discrepancy
2 must not be more than, and must not have 1 times of 1 overrun.
4.5 rapidly dissolving tablet disintegrations
With reference to official method：Take 1, put in 250ml beaker, in beaker, fill 200ml water, water temperature is 15-25 DEG C, has perhaps
Many bubbles are released, and when the gas around tablet or fragment stops effusion, tablet should be dissolved or dispersed in water, no gathering
Grain is left.Unless otherwise specified, 6 are checked with method, each all should disintegrate in 5 minutes.If any 1 can not disintegrate completely, should
Separately take 6 retrials, regulation all should be met.
5 results
5.1 standard curve
In 0.5-7.0 μ g mL-1In the range of, chlorogenic acid obtains peak area with concentration in line in the efficient liquid phase of 327nm
Sexual intercourse, regression equation is：A=63867C-1232.1r=0.9999.HPLC detection chlorogenic acid standard substance and sample liquid phasor
As Fig. 2,3, chlorogenic acid standard curve such as Fig. 4.
5.2 Flos Lonicerae rapidly dissolving tablet prescription screening
5.2.1 rapidly dissolving tablet diluent is that Lactose each prescription ratio is screened
Numbering 1 prescription easy sticking in tableting processes, and the rapidly dissolving tablet obtaining is imperfect.Numbering 2 and numbering 4 rapidly dissolving tablet light
Sliding, the easy sticking of tabletting.The rapidly dissolving tablet that numbering 5 prescription obtains is smooth, but the easy sticking of tableting processes.Numbering 3 prescription obtains rapidly dissolving tablet
Smooth surface, no sticking phenomenon in tableting processes.
Table 1 rapidly dissolving tablet diluent is that Lactose each prescription ratio is screened
5.2.2 rapidly dissolving tablet disintegrating agent sodium bicarbonate and the screening of citric acid ratio
Result such as table 2, investigates tablet surface, smooth degree, sticking situation and disintegration, final choice alkali source：Acid
Source is 1.3:1.
Table 2：Alkali source and acid source ratiometric result
5.3 rapidly dissolving tablet preparation technology result
5.3.1 rapidly dissolving tablet pelletization screening drying time
Drying time is longer, and rapidly dissolving tablet more easily discrete piece, but drying time less sticking phenomenon easily occurs, result is such as
Table 3, final choice is dried 4h.
Table 3 pelletization the selection result drying time
5.3.2 rapidly dissolving tablet diluent is that Lactose each prescription ratio is screened
Numbering 1 prescription easy sticking in tableting processes, and the rapidly dissolving tablet obtaining is imperfect.Numbering 2 and numbering 4 rapidly dissolving tablet light
Sliding, the easy sticking of tabletting.The rapidly dissolving tablet that numbering 5 prescription obtains is smooth, but the easy sticking of tableting processes.Numbering 3 prescription obtains rapidly dissolving tablet
Smooth surface, no sticking phenomenon in tableting processes.As table 4.
Table 4 rapidly dissolving tablet diluent is that Lactose each prescription ratio is screened
5.4 Flos Lonicerae rapidly dissolving tablet quality testings
5.4.1 rapidly dissolving tablet uniformity of dosage units
Result shows the slice, thin piece being all not greater than 15.0, and uniformity of dosage units meets the requirements, such as table 5.
Table 5 Flos Lonicerae rapidly dissolving tablet uniformity of dosage units detects
5.4.2 rapidly dissolving tablet tablet weight variation
Without departing from the tablet of mass discrepancy, tablet weight variation is qualified.
Table 6 rapidly dissolving tablet tablet weight variation
5.4.3 rapidly dissolving tablet disintegration
Six all in disintegrate in 1 minute, after disintegrate solution clarification, no precipitate.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Any modification, equivalent and improvement made within god and principle etc., should be included within the scope of the present invention.
Claims (9)
1. a kind of Flos Lonicerae instant solid beverage it is characterised in that this each component of Flos Lonicerae instant solid beverage in mass ratio by
Flos Lonicerae extractum powder 40%, disintegrating agent 20%-40%, Lactose 20%-40% composition, Flos Lonicerae instant solid beverage gross mass
Ratio is 100%.
2. Flos Lonicerae instant solid beverage as claimed in claim 1 is it is characterised in that described disintegrating agent component is by bicarbonate
Sodium, citric acid composition, described sodium bicarbonate and citric acid mass ratio are：Sodium bicarbonate：Citric acid=1-1.5：1.
3. Flos Lonicerae instant solid beverage as claimed in claim 1 is it is characterised in that in Flos Lonicerae instant solid beverage component
When Lactose mass ratio is 20%, in Flos Lonicerae instant solid beverage component, preferred version one in mass ratio is：
Flos Lonicerae extractum powder is 40%, Lactose 20%, disintegrating agent 40%.
4. Flos Lonicerae instant solid beverage as claimed in claim 1 is it is characterised in that in Flos Lonicerae instant solid beverage component
When Lactose mass ratio is 25%, in Flos Lonicerae instant solid beverage component, preferred version two in mass ratio is：
Flos Lonicerae extractum powder 40%, Lactose 25%, disintegrating agent 35%.
5. Flos Lonicerae instant solid beverage as claimed in claim 1 is it is characterised in that in Flos Lonicerae instant solid beverage component
When Lactose mass ratio is 30%, in Flos Lonicerae instant solid beverage component, preferred version three in mass ratio is:
Flos Lonicerae extractum powder 40%, Lactose 30%, disintegrating agent 30%.
6. Flos Lonicerae instant solid beverage as claimed in claim 1 is it is characterised in that in Flos Lonicerae instant solid beverage component
When Lactose mass ratio is 35%, in Flos Lonicerae instant solid beverage component, preferred version four in mass ratio is:
Flos Lonicerae extractum powder 40%, Lactose 35%, disintegrating agent 25%.
7. Flos Lonicerae instant solid beverage as claimed in claim 1 is it is characterised in that in Flos Lonicerae instant solid beverage component
When Lactose mass ratio is 40%, in Flos Lonicerae instant solid beverage component, preferred version five in mass ratio is:
Flos Lonicerae extractum powder 40%, Lactose 40%, disintegrating agent 20%.
8. a kind of preparation method of Flos Lonicerae instant solid beverage as claimed in claim 1 is it is characterised in that this Flos Lonicerae is instant
The preparation method of solid beverage includes：
Flos Lonicerae extractum powder 40%, disintegrating agent 20%-40%, Lactose 20-40% in mass ratio, pulverizes to after cooling and solidifying
Sodium bicarbonate adds Flos Lonicerae dried powder and pre-dry Lactose, and Flos Lonicerae instant solid beverage gross mass ratio is
100%, and sodium bicarbonate in mass ratio：Citric acid=1-1.5:1 addition adds citric acid, mixing；
Make wetting agent soft material with 2% PVP ethanol, cross 14 mesh sieves and pelletize, 40 DEG C are dried 4h, after granulate, pressure
Piece.
9. the preparation method of Flos Lonicerae instant solid beverage as claimed in claim 8 is it is characterised in that the Flos Lonicerae after tabletting is fast
In molten solid beverage also needs to carry out the mensure of chlorogenic acid, adjuvant measures to chlorogenic acid impact detection, the instant tablet recipe of Flos Lonicerae
The hygroscopicity detection of each raw material, uniformity of dosage units detection, the detection of rapidly dissolving tablet tablet weight variation, rapidly dissolving tablet detection disintegration；
The assay method of chlorogenic acid is：
With 100 μ g mL-1Chlorogenic acid, as storing solution, takes a certain amount of mobile phase to be diluted to 0.5,1,2,3,4,5,6,7 μ respectively
g·mL-1；
Chromatographic column：GeminiI-NX-C18；
Mobile phase, acetonitrile：0.2% phosphoric acid=20:80；
Flow velocity 1.0ml/min；
Sample size 20 μ l, 327nm ultraviolet detection,
X is chlorogenic acid concentration mg/ml, and Y is peak area, and calculates the regression equation of gained standard curve；
Adjuvant to the impact detection method that chlorogenic acid measures is：
By extract powder, Lactose, sodium bicarbonate, citric acid, the order that 2%PVP dehydrated alcohol is pelletized, use 50% ethanol dilution successively
To finite concentration, by above-mentioned efficient liquid phase method, sample introduction 20 μ l, 327nm detect respectively, in terms of peak area and above-mentioned standard curve
Calculate chlorogenic acid content, be repeated 3 times, average；
In the instant tablet recipe of Flos Lonicerae, the hygroscopicity detection method of each raw material is：
Take a certain amount of sample, accurately weighed W0, be positioned over 25 DEG C, relative humidity be in 75% saturation NaCl solution, 2h, 3h,
Take out after 4h, accurately weighed microspheres quality W1,
It is calculated as follows hydroscopicity：Hydroscopicity=[(W1-W0)/W0] × 100%；
Uniformity of dosage units detection method is：
Take test sample 10, measure the relative amount X that every is 100 with labelled amount respectively, ask its average X and standard deviation S and
The absolute value A of the difference of labelled amount and average,
A=100-X；
If A+1.80S≤15.0, that is, the uniformity of dosage units of test sample meets regulation；If A+S>15.0, then against regulation；If A+
1.80S>15.0, and A+S≤15.0, then should separately take 20 retrials；According to first, retrial result, calculate average X, the standard of 30
The absolute value A of the difference of difference S and labelled amount and average；
If A+1.45S≤15.0, that is, the uniformity of dosage units of test sample meets regulation；If A+1.45S>15.0, then against regulation,
Labelled amount is calculated as 7.2mg with chlorogenic acid content；
Rapidly dissolving tablet tablet weight variation detection method is：
Take test sample 20, accurately weighed gross mass, after trying to achieve average piece weight, then the quality of accurately weighed every respectively；Every
Quality is compared with average piece heavy phase, and the tablet beyond mass discrepancy must not be more than 2, and must not have 1 times of 1 overrun；
Rapidly dissolving tablet detection method disintegration is：
Take 1, put in 250ml beaker, in beaker, fill 200ml water, water temperature is 15 DEG C -25 DEG C, have many bubbles to release, work as tablet
Or gas around fragment is when stopping effusion, tablet dissolved or be dispersed in water, the granule of no gathering is left；Check 6 with method,
Each all should disintegrate in 5 minutes；If any 1 can not disintegrate completely, should separately take 6 retrials.
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