CN106381431B - A kind of WE43 magnesium alloy medical bones plate containing Sr and Zn and preparation method thereof - Google Patents

A kind of WE43 magnesium alloy medical bones plate containing Sr and Zn and preparation method thereof Download PDF

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Publication number
CN106381431B
CN106381431B CN201610789412.7A CN201610789412A CN106381431B CN 106381431 B CN106381431 B CN 106381431B CN 201610789412 A CN201610789412 A CN 201610789412A CN 106381431 B CN106381431 B CN 106381431B
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magnesium alloy
hone lamella
alloy medical
bones plate
medical
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CN106381431A (en
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王守仁
黄跃
高文
王又增
林立坡
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University of Jinan
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University of Jinan
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    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C23/00—Alloys based on magnesium
    • C22C23/06—Alloys based on magnesium with a rare earth metal as the next major constituent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/02—Compacting only
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/12—Both compacting and sintering
    • B22F3/14—Both compacting and sintering simultaneously
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/24—After-treatment of workpieces or articles
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/04—Making non-ferrous alloys by powder metallurgy
    • C22C1/0408—Light metal alloys
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
    • C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
    • C22F1/06—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/12—Both compacting and sintering
    • B22F3/14—Both compacting and sintering simultaneously
    • B22F2003/145—Both compacting and sintering simultaneously by warm compacting, below debindering temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/24—After-treatment of workpieces or articles
    • B22F2003/248—Thermal after-treatment

Abstract

The present invention relates to a kind of WE43 magnesium alloy medical bones plate containing Sr and Zn and preparation method thereof.It is characterized in that it is molded by the raw material of following mass percent using hot-pressing sintering technique, Y (yttrium)：4%, RE (rare earth)：3%, Sr (strontium)：0.5%~2%, Zn (zinc)：0.5%~2%, Zr (zirconium)：0.5%, surplus is Mg (magnesium).Its manufacturing process is characterised by being molded using hot-pressing sintering technique, this medical flute profile bone plate is arc-shaped, including bone plate matrix, is arranged at the hone lamella wing of hone lamella matrix both sides, the B class screw holes being arranged on the hone lamella wing, and it is arranged at the A class screw holes at hone lamella matrix both ends；Screw thread is equipped with B classes screw hole and A the class screw hole, for coordinating with corresponding fixing screws, the present invention is simple in construction, avoids more complicated Technology for Heating Processing, and rational component addition has better mechanical performance and decay resistance.

Description

A kind of WE43 magnesium alloy medical bones plate containing Sr and Zn and preparation method thereof
Technical field
The present invention relates to medical bio to be implanted into Material Field, and in particular to a kind of WE43 magnesium alloy medicals containing Sr and Zn Bone plate and preparation method thereof.
Background technology
In recent years, the application of biomedical material has caused material scholar, physician and commercial Application it is extensive Concern.Many medical materials, such as high molecular polymer, ceramics and metal material are had been applied among biomedicine. Metal material plays very important effect as a kind of biomedical material in sclerous tissues's replacement and implantation field.Wherein, Magnesium and magnesium alloy are with its high specific strength, specific stiffness, the modulus of elasticity of good biocompatibility and access expansion bone and close Degree has very big application potential in the implantation of degradable bone, support and tissue.But magnesium and magnesium alloy are as medical embedded The fatal defects of material are that the intensity of pure magnesium is too low, and magnesium alloy in human body environment's internal corrosion too soon so as to causing a large amount of hydrogen Accumulation produces rimhole.Numerous studies show that magnesium and magnesium alloy are after organism is implanted into, due to its biology explanation speed and group Speed of growth mismatch is knitted, ultimately results in operative failure.
The magnesium alloy of system containing aluminium has higher mechanical performance and corrosion resistance, but considers such alloy from health perspectives Do not possess prolonged application in the advantage of human body.At present, relatively popular commercial magnesium alloy is no aluminium system magnesium-rare earth, WE43 Wherein to represent, its component design is Mg-4%Y-3%RE (Nd, Gd) -0.5%Zr.Biotronik companies have made Clinical degradable blood vessel bracket, achieves good effect in zoopery, but WE43 as fixation hone lamella in people The internal and external degradation rate of body is unsatisfactory.Therefore, the more satisfactory magnesium of a kind of comprehensive mechanical intensity and corrosive nature is sought Alloy medical embedded material is most important.
The content of the invention
The present invention is directed to the deficiency of above-mentioned technology, proposes that a kind of magnesium with excellent mechanical performance and decay resistance closes Golden Medical bone fracture plate.
The technical scheme is that：
A kind of WE43 magnesium alloy medical bones plate containing Sr and Zn, it is characterized in that, by the raw material of following mass percent It is molded using hot-pressing sintering technique,
Y (yttrium)：4%, RE (rare earth)：3%, Sr (strontium)：0.5%~2%, Zn (zinc)：0.5%~2%, Zr (zirconium)： 0.5%, surplus is Mg (magnesium).
Preferably, the RE includes Nd elements and/or Gd elements；
Preferably, the RE includes Nd elements and Gd elements；
Preferably, the mass ratio of Nd elements and Gd elements is 1：1.
Preferably,
The Y is Y powder, and Y Powder Particle Sizes are 75 μm, and purity is more than 99.5%；
The RE is RE powder, and the granularity of the RE powder is 75 μm, and purity is more than 99.5%；
The Sr is Sr powder, and the granularity of the Sr powder is 100 μm, and purity is more than 99.5%；
The Zn is Zn powder, and the granularity of the Zn powder is 75 μm, and purity is more than 99.5%；
The Zr is Zr powder, and the granularity of the Zr powder is 100 μm, and purity is more than 99.5%；
The Mg is magnesium powder, and the granularity of Mg powder is 150 μm, and purity is more than 99.5%.
The present invention also provides a kind of WE43 magnesium alloy medical bones plate containing Sr and Zn, it is characterized in that, including bone plate Matrix, the hone lamella wing of hone lamella matrix both sides is arranged at, the B class screw holes being arranged on the hone lamella wing, and it is arranged at hone lamella matrix two The A class screw holes at end；
Screw thread is equipped with B classes screw hole and A the class screw hole, for coordinating with corresponding fixing screws；
Preferably, the cross section of the hone lamella wing is arc-shaped；That is, the hone lamella wing is cross section be arc-shaped groove Type, or other meet the shape of people's skeletal structure, to play more preferable nail effect.
Preferably, the hone lamella wing is at least 2；Such as 2,3,4,5,6,7,8 etc., preferably 2 Individual, 4,6,8 are waited even number.
Preferably, the hone lamella wing is uniformly distributed in hone lamella matrix side；
Preferably, at least one B class screw holes are additionally provided with the hone lamella matrix；For with fixing screws by bone plate It is fixed on skeleton.
Preferably, the B class screw holes on the hone lamella matrix are uniformly distributed, when can make to fix stress evenly, so as to reach To more preferable nail effect.
Preferably, the aperture of A classes screw hole is more than the aperture of B class screw holes；
Preferably, the hone lamella wing is the one or more in flute profile, semi-circular, semiellipse type.
Preferably, the angle that the hone lamella wing and bone plate matrix are formed is 90 °~180 °, such as 90 °, 100 °, 110 °, 120 °, 150 °, 160 ° etc..
Preferably, the angle that the hone lamella wing and bone plate matrix are formed is 100 °~150 °, such as 90 °, 100 °, 110 °, 120 °, 150 ° etc..
Preferably, unanimously (the hone lamella wing is with connecing with people's bone structure trend with the angle that bone plate matrix is formed for the hone lamella wing Hone lamella is dissected according to people's bone and designed, and is arc-shaped)；It is bonded with people's bone, make to fix and more stablize, be more beneficial for the extensive of bone It is multiple.
Preferably, the bone plate is formed in one obtained.
Present invention also offers a kind of preparation method of the WE43 magnesium alloy medical bones plate containing Sr and Zn, its feature It is to comprise the following steps：
1. weigh raw material：Raw material is weighed according to above-mentioned mass percent；
2. batch mixing ball milling：1. Mg, Y, RE, Sr, Zn and Zr raw material that step weighs is taken, is put into ball grinder and carries out after drying Ball milling mixing is into compound；
3. room temperature is compressing：By step 2. described in compound be put into mould be pressed at room temperature, obtain To hone lamella blank；
4. hot pressed sintering：By step 3. in compressing hone lamella blank be positioned in the mould of identical dimensions, will Mould is positioned in the hot-pressed sintering furnace of protective gas protection atmosphere and is sintered；Described protective gas is hot in the prior art Press the protective gas commonly used in sintering process, including but not limited to nitrogen.
5. heat treatment and cooling：Reheat, be incubated after the medical hone lamella demoulding after 4. step sinters is taken out, it is rear cold But the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn are produced to room temperature.
Preferably,
Step 2. in, drum's speed of rotation 100-200r/min, Ball-milling Time 8-12h；
Preferably, step 2. in, drum's speed of rotation 160r/min, Ball-milling Time 10h.
Preferably,
Step 3. in, compressing pressure is 30-60MPa；
Preferably, step 3. in, compressing pressure is 40MPa.
Preferably, step 4. in, the protective gas is nitrogen.
Preferably,
Step 4. in, the condition of sintering is：180-220 DEG C is first warming up to, is incubated 0.5h；550-800 DEG C is warming up to again, is protected Warm 1-3h, pressure control in 30-50MPa all the time；
Step 4. in, the condition of sintering is：200 DEG C are first warming up to, is incubated 0.5h；650 DEG C are warming up to again, are incubated 1h, pressure Power controls in 40MPa all the time.
Preferably,
5. step is heat treatment and cooling：250- is heated to after the medical hone lamella demoulding after 4. step sinters is taken out 350 DEG C, be incubated 2-8h, after be cooled to room temperature and produce the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn；
Preferably,
5. step is heat treatment and cooling：300 are heated to after the medical hone lamella demoulding after 4. step sinters is taken out DEG C, be incubated 5h, after be cooled to room temperature and produce the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn.
Sr elements and Zn elements are human essential elementses, and Zn is such as eyesight, taste in vivo so widely distributed in cell The element needed for physical function such as feel and smell, participates in the metabolism of carbohydrate, protein and phosphorus, promotes normal cell and cell The function of film；Human body contains about 140mg Sr and 99% is located in bone, and formation of the strontium salt to bone has facilitation, there is text Offer and point out, Sr contents 0.3%~2.5% Mg-Sr intravascular stents in intra-arterial 3 weeks without thrombosis.Zn can effectively change The mechanical property of kind magnesium alloy, and improve the corrosion resisting property of magnesium alloy to a certain extent, and Zn elements and Zr element combinations, into For powerful grain refiner；Sr has obvious thinning effect to the crystal grain of magnesium alloy, can also reduce shrinkage cavity quantity in alloy And assemble shrinkage cavity, and the intensity of bone plate is improved, slow down corrosion rate, Sr addition also makes to generate cenotype in magnesium alloy, These stable cenotypes make alloy (magnesium alloy medical bone plate) have preferable creep resisting ability.
The beneficial effects of the present invention are：
(1) the WE43 magnesium alloy medical bones plate containing Sr and Zn of the invention with the addition of human essential elementses Sr elements and Zn elements, while reduce the dosage of rare earth element.
(2) the WE43 magnesium alloy medical bones plate containing Sr and Zn of the invention, improve magnesium alloy medical bone plate Mechanical property, and its corrosion resisting property is improved, and there is preferable creep resisting ability.
(3) the WE43 magnesium alloy medicals bone plate containing Sr and Zn of the invention is with excellent consistency and well Mechanical performance, the density about 1.85g/cm of the WE43 magnesium alloys3, close to people's bone density (1.75g/cm3), modulus of elasticity is about 45GPa, it can eliminate " stress-shielding effect " between implant and people's bone, and (tensile strength is about 250MPa, is bent with WE43 It is about 155MPa to take intensity) to compare, the tensile strength of the Medical bone fracture plate can reach 268MPa, and yield strength is also brought up to 170MPa；And the WE43 magnesium alloys are during corrosion degradation, there is good decay resistance, the rate of dissolution of hone lamella and People's symphysis speed is substantially matching, and the Sr ions discharged in corrosion process being capable of induction of bone growth.
(4) the fitting human body bone table shape of the WE43 magnesium alloy medicals bone plate containing Sr and Zn of the invention, screw hole point Cloth is reasonable, adheres to beneficial to bone tissue and grows.
Brief description of the drawings
Accompanying drawing 1 is the dimensional structure diagram of the embodiment of the present invention；
Accompanying drawing 2 is the front elevational view of the embodiment of the present invention；
Accompanying drawing 3 is the three-dimensional left view of the embodiment of the present invention,
Wherein, 1 is bone plate matrix, and 2 be the flute profile hone lamella wing, and 3 be A class screw holes, and 4 be B class screw holes.
Embodiment
For a better understanding of the present invention, with reference to the embodiment content that the present invention is furture elucidated, but the present invention Content is not limited solely to the following examples, and embodiment is not construed as limiting the scope of the present invention.
A kind of WE43 magnesium alloy medical bones plate containing Sr and Zn, burnt by the raw material of following mass percent using hot pressing Tie technological forming,
Y (yttrium)：4%, RE (rare earth)：3%, Sr (strontium)：0.5%~2%, Zn (zinc)：0.5%~2%, Zr (zirconium)： 0.5%, surplus is Mg (magnesium).
Preferably, the RE includes Nd elements and/or Gd elements；
Preferably, the RE includes Nd elements and Gd elements；
Preferably, the mass ratio of Nd elements and Gd elements is 1：1.
Preferably,
The Y is Y powder, and Y Powder Particle Sizes are 75 μm, and purity is more than 99.5%；
The RE is RE powder, and the granularity of the RE powder is 75 μm, and purity is more than 99.5%；
The Sr is Sr powder, and the granularity of the Sr powder is 100 μm, and purity is more than 99.5%；
The Zn is Zn powder, and the granularity of the Zn powder is 75 μm, and purity is more than 99.5%；
The Zr is Zr powder, and the granularity of the Zr powder is 100 μm, and purity is more than 99.5%；
The Mg is magnesium powder, and the granularity of Mg powder is 150 μm, and purity is more than 99.5%.
The present invention also provides a kind of WE43 magnesium alloy medical bones plate containing Sr and Zn, as shown in Figure 1, 2, 3, including connects Hone lamella matrix 1, the hone lamella wing 2 of hone lamella matrix both sides is arranged at, the B classes screw hole 4 being arranged on the hone lamella wing, and it is arranged at hone lamella The A classes screw hole 3 at matrix both ends；
Screw thread is equipped with the B classes screw hole 4 and A classes screw hole 3, for coordinating with corresponding fixing screws；
Preferably, the cross section of the hone lamella wing is arc-shaped；
Preferably, the hone lamella wing 2 is at least 2；
Preferably, the hone lamella wing 2 is uniformly distributed in the side of hone lamella matrix 1；
Preferably, at least one B classes screw hole 4 is additionally provided with the hone lamella matrix 1；
Preferably, the B classes screw hole 4 on the hone lamella matrix is uniformly distributed；
Preferably, the aperture of A classes screw hole 3 is more than the aperture of B classes screw hole 4；
Preferably, the hone lamella wing 2 is the one or more in flute profile, semi-circular, semiellipse type.
Preferably, the angle that the hone lamella wing 2 is formed with bone plate matrix 1 is 90 °~180 °；
Preferably, the angle that the hone lamella wing 2 is formed with bone plate matrix 1 is 100 °~150 °；
Preferably, the angle that the hone lamella wing 2 and bone plate matrix 1 are formed it is consistent with people's bone structure trend (the hone lamella wing with Bone plate is dissected according to people's bone and designed, and is arc-shaped)；
Preferably, the bone plate is formed in one obtained.
In the use of the present invention, first by the wounded's knochenbruch and the screw to match with A classes screw hole 3 of bone plate matrix 1 It is fixed, the hone lamella wing 2 is then fixed, is finally fixed finally by the screw to match with B classes screw hole 4, the hone lamella wing 2 is deposited Less bone plate is had larger fixation radiation scope, bone plate matrix 1 is fixed with the wounded's knochenbruch more firm, reduce The possibility of operative failure.
The preparation method of the above-mentioned WE43 magnesium alloy medical bones plate containing Sr and Zn, comprises the following steps：
1. weigh raw material：Raw material is weighed according to above-mentioned mass percent；
2. batch mixing ball milling：1. Mg, Y, RE, Sr, Zn and Zr raw material that step weighs is taken, is put into ball grinder and carries out after drying Ball milling mixing is into compound；
3. room temperature is compressing：By step 2. described in compound be put into mould be pressed at room temperature, obtain To hone lamella blank；
4. hot pressed sintering：By step 3. in compressing hone lamella blank be positioned in the mould of identical dimensions, will Mould is positioned in the hot-pressed sintering furnace of protective gas protection atmosphere and is sintered；
5. heat treatment and cooling：Reheat, be incubated after the medical hone lamella demoulding after 4. step sinters is taken out, it is rear cold But the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn are produced to room temperature.
Preferably,
Step 2. in, 100~200r/min of drum's speed of rotation, Ball-milling Time 8-12h；
Preferably, step 2. in, drum's speed of rotation 160r/min, Ball-milling Time 10h.
Preferably,
Step 3. in, compressing pressure is 30-60MPa；
Preferably, step 3. in, compressing pressure is 40MPa.
Preferably,
Step 4. in, the protective gas is nitrogen.
Preferably,
Step 4. in, the condition of sintering is：180-220 DEG C is first warming up to, is incubated 0.5h；550-800 DEG C is warming up to again, is protected Warm 1-3h, pressure control in 30-50MPa all the time；
Step 4. in, the condition of sintering is：200 DEG C are first warming up to, is incubated 0.5h；650 DEG C are warming up to again, are incubated 1h, pressure Power controls in 40MPa all the time.
Preferably,
5. step is heat treatment and cooling：250- is heated to after the medical hone lamella demoulding after 4. step sinters is taken out 350 DEG C, be incubated 2-8h, after be cooled to room temperature and produce the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn；
Preferably,
5. step is heat treatment and cooling：300 are heated to after the medical hone lamella demoulding after 4. step sinters is taken out DEG C, be incubated 5h, after be cooled to room temperature and produce the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn.
With reference to specific embodiment, the present invention will be described, but the present invention is not limited only to these examples.Embodiment 1
A kind of WE43 magnesium alloy medical bones plate containing Sr and Zn, burnt by the raw material of following mass percent using hot pressing Tie technological forming,
Y (Y powder, Y Powder Particle Sizes are 75 μm, and purity is more than 99.5%)：(RE powder, the granularity of RE powder is 75 μm, pure by 4%, RE Degree is more than 99.5%)：3%, Sr (Sr powder, the granularity of the Sr powder is 100 μm, and purity is more than 99.5%)：0.5%, Zn (Zn powder, the granularity of the Zn powder is 75 μm, and purity is more than 99.5%)：(Zr powder, the granularity of the Zr powder are by 0.5%, Zr 100 μm, purity is more than 99.5%)：0.5%, surplus be Mg (magnesium powder, the granularity of Mg powder are 150 μm, purity 99.5% with On).
In the present embodiment, the preparation method of the WE43 magnesium alloy medical bones plate containing Sr and Zn comprises the following steps：
1. weigh raw material：Raw material is weighed according to above-mentioned mass percent；
2. batch mixing ball milling：1. Mg, Y, RE, Sr, Zn and Zr raw material that step weighs is taken, is put into ball grinder and carries out after drying Ball milling mixing into compound, wherein, drum's speed of rotation 160r/min, Ball-milling Time 10h；
3. room temperature is compressing：By step 2. described in compound be put into mould be pressed at room temperature, obtain To hone lamella blank, wherein, compressing pressure is 40MPa.
4. hot pressed sintering：By step 3. in compressing hone lamella blank be positioned in the mould of identical dimensions, will Mould is positioned in the hot-pressed sintering furnace that nitrogen protective atmosphere encloses and is sintered, and the condition of sintering is：200 DEG C are first warming up to, insulation 0.5h；650 DEG C are warming up to again, is incubated 1h, and pressure controls in 40MPa all the time.
5. heat treatment and cooling：300 DEG C are heated to after the medical hone lamella demoulding after 4. step sinters is taken out, insulation 5h, after be cooled to room temperature and produce the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn.
Embodiment 2
A kind of WE43 magnesium alloy medical bones plate containing Sr and Zn, burnt by the raw material of following mass percent using hot pressing Tie technological forming,
Y (yttrium)：4%, RE (rare earth)：3%, Sr (strontium)：1%, Zn (zinc)：1%, Zr (zirconium)：0.5%, surplus Mg (magnesium).
Preparation method is the same as embodiment 1.
Embodiment 3
A kind of WE43 magnesium alloy medical bones plate containing Sr and Zn, burnt by the raw material of following mass percent using hot pressing Tie technological forming,
Y (yttrium)：4%, RE (rare earth)：3%, Sr (strontium)：2%, Zn (zinc)：2%, Zr (zirconium)：0.5%, surplus Mg (magnesium).
Preparation method is the same as embodiment 1.
It is specifically shown in table 1 below.
The composition (weight/mass percentage composition wt%) of alloy used in the embodiment of table 1
Bone plate is numbered Mg Y RE Sr Zn Zr
Embodiment 1 Surplus 4 3 0.5 0.5 0.5
Embodiment 2 Surplus 4 3 1 1 0.5
Embodiment 3 Surplus 4 3 2 2 0.5
Decay resistance is tested：According to national standard GB/T10125-1997, to above-mentioned manufactured embodiment 1, embodiment 2 and reality The Medical bone fracture plate for applying example 3 carries out standard Neutral salt spray test, show that performance data is shown in Table 2.
The salt spray corrosion resistance of the medical flute profile hone lamella of table 2
Hone lamella is numbered There is the time/h corroded Corrosion rate/mgcm-2·h-1
Embodiment 1 8.8 0.023
Embodiment 2 10 0.017
Embodiment 3 7.6 0.031
From in table 2, when alloying component is in composition range given to this invention, its excellent anti-corrosion performance, Wherein, the Mg-4%Y-3%RE-1%Sr-1%Zn-0.5%Zr Medical bone fracture plate decay resistances in embodiment 2 are best.

Claims (25)

1. a kind of WE43 magnesium alloy medical bones plate containing Sr and Zn, it is characterized in that, adopted by the raw material of following mass percent It is molded with hot-pressing sintering technique,
Y：4%, RE：3%, Sr：0.5%~2%, Zn：0.5%~2%, Zr：0.5%, surplus Mg；
The preparation method of the above-mentioned WE43 magnesium alloy medical bones plate containing Sr and Zn, comprises the following steps：
1. weigh raw material：Raw material is weighed according to above-mentioned mass percent；
2. batch mixing ball milling：1. Mg, Y, RE, Sr, Zn and Zr raw material that step weighs is taken, is put into after drying in ball grinder and carries out ball milling It is mixed into compound；
3. room temperature is compressing：By step 2. described in compound be put into mould be pressed at room temperature, obtain bone Plate blank material；
4. hot pressed sintering：By step 3. in compressing hone lamella blank be positioned in the mould of identical dimensions, by mould It is positioned in the hot-pressed sintering furnace of protective gas protection atmosphere and is sintered；
The condition of sintering is：180-220 DEG C is first warming up to, is incubated 0.5h；550-800 DEG C is warming up to again, is incubated 1-3h, and pressure begins Control is in 30-50MPa eventually；
5. heat treatment and cooling：By after 4. step sinters medical hone lamella the demoulding take out after reheat, be incubated, after be cooled to Room temperature produces the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn；
It is heat-treated and is cooled to：250-350 DEG C is heated to after the medical hone lamella demoulding after 4. step sinters is taken out, insulation 2-8h, after be cooled to room temperature and produce the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn.
2. the WE43 magnesium alloy medical bones plate according to claim 1 containing Sr and Zn, it is characterized in that, the RE is Nd Element and/or Gd elements.
3. the WE43 magnesium alloy medical bones plate according to claim 2 containing Sr and Zn, it is characterized in that, the RE is Nd Element and Gd elements.
4. the WE43 magnesium alloy medical bones plate containing Sr and Zn according to Claims 2 or 3, it is characterized in that, Nd elements Mass ratio with Gd elements is 1：1.
5. the WE43 magnesium alloy medical bones plate according to claim 1 or 2 containing Sr and Zn, it is characterized in that,
The Y is Y powder, and Y Powder Particle Sizes are 75 μm, and purity is more than 99.5%；
The RE is RE powder, and the granularity of the RE powder is 75 μm, and purity is more than 99.5%；
The Sr is Sr powder, and the granularity of the Sr powder is 100 μm, and purity is more than 99.5%；
The Zn is Zn powder, and the granularity of the Zn powder is 75 μm, and purity is more than 99.5%；
The Zr is Zr powder, and the granularity of the Zr powder is 100 μm, and purity is more than 99.5%；
The Mg is magnesium powder, and the granularity of Mg powder is 150 μm, and purity is more than 99.5%.
6. a kind of WE43 magnesium alloy medical bones plate according to claim 1 containing Sr and Zn, it is characterized in that, including connect Hone lamella matrix, the hone lamella wing of hone lamella matrix both sides is arranged at, the B class screw holes being arranged on the hone lamella wing, and it is arranged at hone lamella base The A class screw holes at body both ends；
Screw thread is equipped with B classes screw hole and A the class screw hole, for coordinating with corresponding fixing screws.
7. the WE43 magnesium alloy medical bones plate according to claim 6 containing Sr and Zn, it is characterized in that, the hone lamella wing Cross section be arc-shaped.
8. the WE43 magnesium alloy medical bones plate according to claim 6 containing Sr and Zn, it is characterized in that, the hone lamella wing At least 2.
9. the WE43 magnesium alloy medical bones plate containing Sr and Zn according to claim 6 or 8, it is characterized in that, the bone The plate wing is uniformly distributed in hone lamella matrix side.
10. the WE43 magnesium alloy medical bones plate according to claim 6 containing Sr and Zn, it is characterized in that, the hone lamella At least one B class screw holes are additionally provided with matrix.
11. the WE43 magnesium alloy medical bones plate according to claim 10 containing Sr and Zn, it is characterized in that, the hone lamella B class screw holes on matrix are uniformly distributed.
12. the WE43 magnesium alloy medical bones plate according to claim 6 containing Sr and Zn, it is characterized in that, A class screw holes Aperture be more than B class screw holes aperture.
13. the WE43 magnesium alloy medical bones plate according to claim 6 containing Sr and Zn, it is characterized in that, the hone lamella The wing is the one or more in flute profile, semi-circular, semiellipse type.
14. the WE43 magnesium alloy medical bones plate according to claim 6 containing Sr and Zn, it is characterized in that, the hone lamella The angle that the wing is formed with bone plate matrix is 90 °~180 °.
15. the WE43 magnesium alloy medical bones plate according to claim 14 containing Sr and Zn, it is characterized in that, the hone lamella The angle that the wing is formed with bone plate matrix is 100 °~150 °.
16. the WE43 magnesium alloy medical bones plate according to claim 14 containing Sr and Zn, it is characterized in that, the hone lamella The wing is consistent with people's bone structure trend with the angle that bone plate matrix is formed.
17. the WE43 magnesium alloy medical bones plate according to claim 6 containing Sr and Zn, it is characterized in that, the synthetism Plate is formed in one obtained.
18. a kind of preparation method of the WE43 magnesium alloy medical bones plate containing Sr and Zn, it is characterized in that, comprise the following steps：
1. weigh raw material：Raw material is weighed according to any described mass percents of claim 1-5；
2. batch mixing ball milling：1. Mg, Y, RE, Sr, Zn and Zr raw material that step weighs is taken, is put into after drying in ball grinder and carries out ball milling It is mixed into compound；
3. room temperature is compressing：By step 2. described in compound be put into mould be pressed at room temperature, obtain bone Plate blank material；
4. hot pressed sintering：By step 3. in compressing hone lamella blank be positioned in the mould of identical dimensions, by mould It is positioned in the hot-pressed sintering furnace of protective gas protection atmosphere and is sintered；
The condition of sintering is：180-220 DEG C is first warming up to, is incubated 0.5h；550-800 DEG C is warming up to again, is incubated 1-3h, and pressure begins Control is in 30-50MPa eventually；
5. heat treatment and cooling：By after 4. step sinters medical hone lamella the demoulding take out after reheat, be incubated, after be cooled to Room temperature produces the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn；
It is heat-treated and is cooled to：250-350 DEG C is heated to after the medical hone lamella demoulding after 4. step sinters is taken out, insulation 2-8h, after be cooled to room temperature and produce the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn.
19. the preparation method of the WE43 magnesium alloy medical bones plate according to claim 18 containing Sr and Zn, its feature It is,
Step 2. in, drum's speed of rotation 100-200r/min, Ball-milling Time 8-12h.
20. the preparation method of the WE43 magnesium alloy medical bones plate according to claim 19 containing Sr and Zn, its feature It is,
Step 2. in, drum's speed of rotation 160r/min, Ball-milling Time 10h.
21. the preparation method of the WE43 magnesium alloy medical bones plate according to claim 18 containing Sr and Zn, its feature It is,
Step 3. in, compressing pressure is 30-60MPa.
22. the preparation method of the WE43 magnesium alloy medical bones plate according to claim 21 containing Sr and Zn, its feature It is,
Step 3. in, compressing pressure is 40MPa.
23. the preparation method of the WE43 magnesium alloy medical bones plate according to claim 18 containing Sr and Zn, its feature It is,
Step 4. in, the protective gas is nitrogen.
24. the preparation method of the WE43 magnesium alloy medical bones plate according to claim 18 containing Sr and Zn, its feature It is,
Step 4. in, the condition of sintering is：200 DEG C are first warming up to, is incubated 0.5h；650 DEG C are warming up to again, is incubated 1h, and pressure begins Control is in 40MPa eventually.
25. the preparation method of the WE43 magnesium alloy medical bones plate according to claim 18 containing Sr and Zn, its feature It is,
5. step is heat treatment and cooling：300 DEG C are heated to after the medical hone lamella demoulding after 4. step sinters is taken out, is protected Warm 5h, after be cooled to room temperature and produce the WE43 magnesium alloy medical flute profile bones plate containing Sr and Zn.
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CN107496020A (en) * 2017-09-29 2017-12-22 赵德伟 A kind of degradable pure magnesium metal bone fracture plate fixed for Long bone fracture
CN107747014B (en) * 2017-10-26 2019-09-24 东北大学 One kind having high ductibility high-strength magnesium alloy and preparation method thereof
CN108186097B (en) * 2018-01-05 2024-04-16 济南大学 Magnesium alloy bone fracture plate and manufacturing method thereof
CN109330674B (en) * 2018-09-07 2021-02-02 西安卓恰医疗器械有限公司 Internal fixing system and using method thereof
CN109022984B (en) * 2018-09-25 2021-01-19 中国科学院海洋研究所 Zn-containing corrosion-resistant rare earth magnesium alloy and preparation method thereof
CN109351980B (en) * 2018-12-06 2022-05-10 南京理工大学 Method for preparing multi-scale precipitation strengthening magnesium alloy material by hot pressing sintering method
CN113122761A (en) * 2021-03-09 2021-07-16 珠海中科先进技术研究院有限公司 Degradable, tough and strong magnesium alloy and preparation method and application thereof
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