CN106377539A - Chlorophyll ferrous microcapsule and preparation method thereof - Google Patents
Chlorophyll ferrous microcapsule and preparation method thereof Download PDFInfo
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- CN106377539A CN106377539A CN201610736436.6A CN201610736436A CN106377539A CN 106377539 A CN106377539 A CN 106377539A CN 201610736436 A CN201610736436 A CN 201610736436A CN 106377539 A CN106377539 A CN 106377539A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
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Abstract
The present invention relates to a chlorophyll ferrous microcapsule and a preparation method thereof and belongs to the technical field of medicines. The chlorophyll ferrous microcapsule overcomes the defects that the clinical effect of chlorophyll ferrous is poor and the drug loading capacity is limited due to the adoption of multiple core materials in the prior art. The core materials of the chlorophyll ferrous microcapsule are improved in prescription and a corresponding preparation method is provided. The chlorophyll ferrous microcapsule prepared based on the above method is high in drug loading capacity and encapsulation efficiency. The effect of the chlorophyll ferrous microcapsule is significantly superior to the individual application effect of chlorophyll ferrous in clinically treating anemia. Therefore, the chlorophyll ferrous microcapsule has a good application prospect.
Description
Technical field
The present invention relates to a kind of chlorophyll ferrous iron microcapsule and preparation method thereof, belong to pharmaceutical technology field.
Background technology
Chlorophyll ferrous iron is a kind of natural green pigment with iron supplement health care, except can be used in ferrous-fortifier,
Outside treatment iron deficiency anemia, also act as the auxiliary treatment of some chronic diseases.Chlorophyll ferrous iron has antibacterial, antiviral, anti-mistake
The effects such as quick and promotion organization regeneration, are a kind of good hematopoietic cell complexing agents, the leukopenia that a variety of causes is caused
Disease and various anemia have therapeutical effect, and its iron supplement effect is better than chlorophyll iron.But the ferrous less stable of chlorophyll, especially exists
Under the conditions of illumination, high temperature etc..Micro encapsulation can mitigate the influence degree to sensitive core for the external environment, increases oxidizable, easy
Stability of volatilization, heliosensitivity and heat sensitive material etc., thus improving its storge quality, improves operability.
《The preparation of chitin-sodium alginate chlorophyll ferrous iron microcapsule and sustained release performance research》One one kind disclosed herein
The preparation method of microcapsule, it specifically includes following steps：Weigh appropriate CaCl2, with 1.0% acetic acid and be diluted to
The CaCl of 20mg/mL2Solution.Take appropriate shitosan, with the dissolving of above-mentioned calcium chloride solution, adjust solution with 0.10mol/L NaOH
PH value is 5.5.Prepare the chlorophyll ferrous iron solution of certain mass concentration, and be dissolved in wherein with a certain proportion of sodium alginate.Take
The ferrous sodium alginate soln of 4mL chlorophyll, slowly drops to the shitosan chlorine filling 20mL with the 5mL syringe with No. 8 syringe needles
Change in calcium solution, Deca height 20mm, stand 30min after dripping off, filter and wash with water 3 times, collect microsphere, vacuum drying.
The ferrous microencapsulated rate of chlorophyll that the method prepares is higher, but its clinical practice is in treatment for anemia effect on driving birds is not good.《By
Folium Allium sativum L prepares chlorophyll ferrous iron sodium salt and its stability study》In one literary composition, the Folium Allium sativum L after purified treatment is smashed pulping, warp
The processes such as saponification, acidifying, ferrum generation, prepared chlorophyll ferrous iron sodium salt.Result shows, this technique can reduce making of organic solvent
With, products obtained therefrom good water solubility, good stability in acid condition, but stable under alkaline conditions is deteriorated；Light is stablized
Property poor, temperature be less than 80 DEG C when better heat stability；There is resistance to reducing power well, oxidation resistent susceptibility is poor；Cu2+、Fe3+
With citric acid, the absorbance of chlorophyll ferrous iron sodium salt is had an impact, other additives have no significant effect to its absorbance.
Content of the invention
In prior art《The preparation of chitin-sodium alginate chlorophyll ferrous iron microcapsule and sustained release performance research》Disclose
A kind of preparation method of the high chlorophyll ferrous iron microcapsule of envelop rate, but it is applied to less effective during Clinical practice, and its
Core includes drug loading during many kinds of substance and is restricted.In order to overcome the above-mentioned deficiencies of the prior art, the present invention provides a kind of load
Dose is high, good chlorophyll ferrous iron microcapsule of clinical effectiveness and preparation method thereof, and applicant is changed to the prescription in core
Enter, and provide corresponding preparation method, the microcapsule drug loading of this technique preparation is high and has higher envelop rate, uses
It is significantly better than chlorophyll ferrous iron to be used alone when clinical treatment for anemia, therefore there is good application prospect.
The present invention is achieved through the following technical solutions above-mentioned technique effect：
A kind of chlorophyll ferrous iron microcapsule, its preparation technology specifically includes following steps：
1) prepare core material solution：Accurately weigh 20-30 weight portion chlorophyll ferrous iron, 10-20 weight portion chrysophanic acid and 10-20
Weight portion icariin, joins it in 200 parts of erithritols, stirs, obtain core material solution；
2) prepare wall material solution：Weigh guar gum and the 200-500 weight portion modified starch of 50-150 weight portion, plus
550-1350 weight portion erithritol dissolves, and obtains wall material solution；
3) microcapsule preparation：Control core dry for the 15～28% of wall material solution dry matter weight, by core material solution
It is mixed to get dispersion liquid with wall material solution；Add in dispersion liquid its weight 0.5～1.5% two Plurol Oleique CC497s and
The blended emulsifier of 1～1.4% sucrose fatty acid ester, after stirring 65～83 DEG C, 18～32MPa condition emulsified, spray
Mist is dried, and obtains final product chlorophyll ferrous iron microcapsule.
In chlorophyll ferrous iron microcapsule preparation method described above, the dry of described core material solution is by 25 weight portions
Chlorophyll is ferrous, 15 weight portion chrysophanic acids and 15 weight portion icariin form.
In chlorophyll ferrous iron microcapsule preparation method described above, the dry of described wall material solution is by 100 portions of melons
That locust beam gum and 350 parts of modified starches compositions.
In chlorophyll ferrous iron microcapsule preparation method described above, described step 3) dispersion liquid in core dry be
The 22% of wall material solution dry matter weight.In described blended emulsifier, the addition of two Plurol Oleique CC497s is dispersion liquid weight
The 1% of amount, the addition of described sucrose fatty acid ester is the 1.2% of dispersion liquid weight.
In chlorophyll ferrous iron microcapsule preparation method described above, described emulsification condition is：Emulsifying temperature be 74 DEG C,
Emulsification pressure is 20MPa.
In chlorophyll ferrous iron microcapsule preparation method described above, the condition of described spray drying is：Inlet temperature is
160～180 DEG C, leaving air temp is 85～105 DEG C, and atomizing pressure is 0.25～0.45MPa.
Chlorophyll ferrous iron microcapsule preparation method of the present invention is simple, and the drug loading of microcapsule is big, and envelop rate is high.
, between 92-97%, drug loading is in 40- for the envelop rate of the chlorophyll ferrous iron microcapsule of embodiment of the present invention 1- embodiment 5 gained
Between 46%, higher than the chlorophyll ferrous iron microcapsule described in comparative example 1-3, and there is the difference of significance.This shows,
The technological feasibility of chlorophyll ferrous iron microcapsule of the present invention is strong, and using of emulsifier type can be to chlorophyll ferrous iron microcapsule
Envelop rate and drug loading produce significant impact.
Various ingredients are added, it has significant synergism when treating anemia in described core.The present invention is real
Apply the chlorophyll ferrous iron microcapsule described in 1- embodiment 5 and comparative example 1 is better than for rabbit treatment for anemia effect is significant, right
Also it is significantly better than comparative example 1 than the therapeutic effect of embodiment 2 and comparative example 3, this shows, chlorophyll is ferrous, big
Yellow acid and icariin have significant synergism in terms for the treatment of anemia, and therapeutic effect is better than being used alone chlorophyll Asia
Ferrum.And the chlorophyll ferrous iron microcapsule described in embodiment of the present invention 1- embodiment 5 is better than comparative example 2 and comparative example 3,
This shows, its release profiles in vivo is more conducive to the absorption of human body, and the bioavailability of medicine is higher.
It can thus be seen that the present invention compared with prior art it is a technical advantage that：
1) provide one kind and treat treatment for anemia effect more preferable chlorophyll ferrous iron microcapsule formulation, its pharmaceutical preparation middle period
Verdazulene is ferrous, chrysophanic acid and icariin have significant synergism in terms for the treatment of anemia.
2) provide a kind of preparation method of above-mentioned chlorophyll ferrous iron microcapsule formulation, its envelop rate and drug loading are all very
Ideal, better than the preparation method of existing chlorophyll ferrous iron microcapsule formulation.
3) technique in the preparation method of chlorophyll ferrous iron microcapsule formulation and supplementary product kind are optimized.Determine impact system
Agent stability and internal release key parameter, and here determines optimal preparation process thereof.
Specific embodiment
Further describe the present invention below by way of specific embodiment, but described embodiment never in any form restriction are originally specially
The protection domain of profit.
A kind of chlorophyll of embodiment 1 ferrous iron microcapsule and its preparation technology
A kind of chlorophyll ferrous iron microcapsule, its preparation technology specifically includes following steps：
1) prepare core material solution：Accurately weigh 20 weight portion chlorophylls ferrous irons, 10 weight portion chrysophanic acids and 10 weight portions excessive
Sheep icariin, joins it in 200 parts of erithritols, stirs, obtain core material solution；
2) prepare wall material solution：Weigh guar gum and the 200 weight portion modified starches of 50 weight portions, plus 550 weight portions
Erithritol dissolves, and obtains wall material solution；
3) microcapsule preparation：Control core dry for the 15% of wall material solution dry matter weight, by core material solution and wall
Material solution is mixed to get dispersion liquid；The 0.5% of its weight two Plurol Oleique CC497s and 1% Sucrose Fatty Acid Ester is added in dispersion liquid
The blended emulsifier of fat acid esters, after stirring 65 DEG C, 18MPa condition emulsified, be spray-dried, obtain final product chlorophyll ferrous iron micro-
Capsule, the condition of wherein said spray drying is：Inlet temperature is 160 DEG C, and leaving air temp is 85 DEG C, and atomizing pressure is
0.25MPa.
A kind of chlorophyll of embodiment 2 ferrous iron microcapsule and its preparation technology
A kind of chlorophyll ferrous iron microcapsule, its preparation technology specifically includes following steps：
1) prepare core material solution：Accurately weigh 25 weight portion chlorophylls ferrous irons, 15 weight portion chrysophanic acids and 15 weight portions excessive
Sheep icariin, joins it in 200 parts of erithritols, stirs, obtain core material solution；
2) prepare wall material solution：Weigh guar gum and the 350 weight portion modified starches of 100 weight portions, plus 950 weight portions
Erithritol dissolves, and obtains wall material solution；
3) microcapsule preparation：Control core dry for the 22% of wall material solution dry matter weight, by core material solution and wall
Material solution is mixed to get dispersion liquid；The 1% of its weight two Plurol Oleique CC497s and 1.2% Sucrose Fatty Acid Ester is added in dispersion liquid
The blended emulsifier of fat acid esters, after stirring 74 DEG C, 25MPa condition emulsified, be spray-dried, obtain final product chlorophyll ferrous iron micro-
Capsule, the condition of wherein said spray drying is：Inlet temperature is 170 DEG C, and leaving air temp is 95 DEG C, and atomizing pressure is
0.35MPa.
A kind of chlorophyll of embodiment 3 ferrous iron microcapsule and its preparation technology
A kind of chlorophyll ferrous iron microcapsule, its preparation technology specifically includes following steps：
1) prepare core material solution：Accurately weigh 30 weight portion chlorophylls ferrous irons, 20 weight portion chrysophanic acids and 20 weight portions excessive
Sheep icariin, joins it in 200 parts of erithritols, stirs, obtain core material solution；
2) prepare wall material solution：Weigh guar gum and the 500 weight portion modified starches of 150 weight portions, plus 1350 weight
Part erithritol dissolving, obtains wall material solution；
3) microcapsule preparation：Control core dry for the 28% of wall material solution dry matter weight, by core material solution and wall
Material solution is mixed to get dispersion liquid；The 1.5% of its weight two Plurol Oleique CC497s and 1.4% sucrose is added in dispersion liquid
The blended emulsifier of fatty acid ester, after stirring 83 DEG C, 32MPa condition emulsified, be spray-dried, obtain final product chlorophyll ferrous
Microcapsule, the condition of wherein said spray drying is：Inlet temperature is 180 DEG C, and leaving air temp is 105 DEG C, and atomizing pressure is
0.45MPa.
A kind of chlorophyll of embodiment 4 ferrous iron microcapsule and its preparation technology
A kind of chlorophyll ferrous iron microcapsule, its preparation technology specifically includes following steps：
1) prepare core material solution：Accurately weigh 20 weight portion chlorophylls ferrous irons, 20 weight portion chrysophanic acids and 10 weight portions excessive
Sheep icariin, joins it in 200 parts of erithritols, stirs, obtain core material solution；
2) prepare wall material solution：Weigh guar gum and the 200 weight portion modified starches of 150 weight portions, plus 1350 weight
Part erithritol dissolving, obtains wall material solution；
3) microcapsule preparation：Control core dry for the 15% of wall material solution dry matter weight, by core material solution and wall
Material solution is mixed to get dispersion liquid；The 1.5% of its weight two Plurol Oleique CC497s and 1～1.4% are added in dispersion liquid
The blended emulsifier of sucrose fatty acid ester, after stirring 65 DEG C, 32MPa condition emulsified, be spray-dried, obtain final product chlorophyll
Ferrous microcapsule, the condition of wherein said spray drying is：Inlet temperature is 160 DEG C, and leaving air temp is 105 DEG C, atomizing pressure
For 0.25MPa.
A kind of chlorophyll of embodiment 5 ferrous iron microcapsule and its preparation technology
A kind of chlorophyll ferrous iron microcapsule, its preparation technology specifically includes following steps：
1) prepare core material solution：Accurately weigh 30 weight portion chlorophylls ferrous irons, 10 weight portion chrysophanic acids and 20 weight portions excessive
Sheep icariin, joins it in 200 parts of erithritols, stirs, obtain core material solution；
2) prepare wall material solution：Weigh guar gum and the 500 weight portion modified starches of 50 weight portions, plus 1350 weight portions
Erithritol dissolves, and obtains wall material solution；
3) microcapsule preparation：Control core dry for the 28% of wall material solution dry matter weight, by core material solution and wall
Material solution is mixed to get dispersion liquid；The 0.5% of its weight two Plurol Oleique CC497s and 1.4% sucrose is added in dispersion liquid
The blended emulsifier of fatty acid ester, after stirring 65 DEG C, 32MPa condition emulsified, be spray-dried, obtain final product chlorophyll ferrous
Microcapsule, the condition of wherein said spray drying is：Inlet temperature is 160 DEG C, and leaving air temp is 105 DEG C, and atomizing pressure is
0.25MPa.
Comparative example 1 according to《The preparation of chitin-sodium alginate chlorophyll ferrous iron microcapsule and sustained release performance research》
The chlorophyll ferrous iron microcapsule that disclosed preparation method prepares, it specifically includes following steps：Weigh appropriate CaCl2, with
1.0% acetic acid is simultaneously diluted to the CaCl of 20mg/mL2Solution.Take appropriate shitosan, with the dissolving of above-mentioned calcium chloride solution, use
It is 5.5 that 0.10mol/L NaOH adjusts solution ph.Prepare the chlorophyll ferrous iron solution of certain mass concentration, and with certain proportion
Sodium alginate be dissolved in wherein.Take the ferrous sodium alginate soln of 4mL chlorophyll, slowly dripped with the 5mL syringe with No. 8 syringe needles
To the shitosan calcium chloride solution filling 20mL, Deca height 20mm, stand 30min after dripping off, filter and wash 3 with water
Secondary, collect microsphere, vacuum drying.
Comparative example 2 according to《The preparation of chitin-sodium alginate chlorophyll ferrous iron microcapsule and sustained release performance research》
The chlorophyll ferrous iron microcapsule that disclosed preparation method prepares, it is real that difference is that chlorophyll ferrous iron solution replaces with the present invention
Apply the core material solution described in example 2.
Comparative example 3 prepares chlorophyll ferrous iron microcapsule according to the preparation method described in the embodiment of the present invention 2, and difference exists
In adding the 1% of its weight monoglyceride and the blended emulsifier of 1.2% sucrose fatty acid ester in dispersion liquid.
The embodiment 6 chlorophyll of the present invention ferrous iron envelop rate of microcapsule and the mensure of drug loading
Measure the bag of the chlorophyll ferrous iron microcapsule that embodiment of the present invention 1-5 and comparative example 1-3 are obtained respectively
Envelope rate and drug loading, test result is as shown in table 1：
The table 1 chlorophyll of the present invention ferrous iron envelop rate of microcapsule and the mensure of drug loading
| Envelop rate (%) | Drug loading (%) | |
| Embodiment 1 | 95.6 | 42.8 |
| Embodiment 2 | 97.9 | 45.9 |
| Embodiment 3 | 94.1 | 42.3 |
| Embodiment 4 | 91.7 | 40.8 |
| Embodiment 5 | 92.5 | 42.6 |
| Comparative example 1 | 82.3 | 34.1 |
| Comparative example 2 | 51.3 | 20.4 |
| Comparative example 3 | 61.5 | 31.6 |
As can be seen from Table 1, the envelop rate of the chlorophyll ferrous iron microcapsule of embodiment of the present invention 1- embodiment 5 gained exists
Between 92-97%, drug loading between 40-46%, higher than described in comparative example 1-3 chlorophyll ferrous iron microcapsule, and
There is the difference of significance.This shows, the technological feasibility of chlorophyll of the present invention ferrous iron microcapsule is strong, and the making of emulsifier type
With meeting, significant impact is produced to the envelop rate of chlorophyll ferrous iron microcapsule and drug loading.
The embodiment 7 chlorophyll ferrous iron therapeutical effect to anemia Rabbit Model for the microcapsule
Modeling method and administration：New zealand rabbit 90, male and female half and half, body weight 2.5～3.0kg, rabbit press body weight, sex with
Machine is grouped, every group 10, male and female half and half. and model group and each administration group rabbit are all in the 1st, 4,7 days dorsal sc injection acetophenones
Hydrazine.Acetylphenylhydrazine faces the used time with normal saline dilution as 20mg/ml, and first dosage is 10ml/kg (0.2g/kg), subtracts for the 2nd, 3 times
Half, normal group same method gives normal saline.Each group starts to start to be administered in modeling, and dosage is 20mg/kg/d,
Successive administration 20 days, the 21st Lepus empty stomach auricular vein take erythrocyte (RED) in hematometry peripheral blood, hemoglobin (HGB) and
Reticulocyte (RET) counts.
3 experimental results
Table 2：Rabbit blood analyticses testing result
| Group | RBC (1012/L) | HGB (109/L) | RET (%) |
| Normal group | 5.65±1.23 | 106.37±3.16 | 3.45±0.70 |
| Model group | 2.38±0.52## | 62.30±1.05## | 4.42±1.62# |
| Embodiment 1 | 3.87±0.67* | 76.34±1.11* | 4.32±1.34 |
| Embodiment 2 | 5.39±0.72** | 102.63±1.26** | 7.61±1.14* |
| Embodiment 3 | 4.68±0.75** | 90.59±1.35** | 6.59±1.27** |
| Embodiment 4 | 3.98±0.45* | 87.54±0.98 | 4.52±1.26 |
| Embodiment 5 | 4.24±0.62* | 72.65±1.38* | 4.85±1.34* |
| Comparative example 1 | 2.86±0.31* | 72.54±0.98 | 3.22±1.15 |
| Comparative example 2 | 3.23±0.25* | 85.65±1.38* | 4.28±1.29* |
| Comparative example 3 | 3.18±0.35* | 87.54±0.98 | 3.86±1.22 |
Compare with normal group,#P ＜ 0.05,##P ＜ 0.01；Compare with model group,*P ＜ 0.05,**P ＜ 0.01；
As can be seen from Table 2, the chlorophyll ferrous iron microcapsule described in embodiment of the present invention 1- embodiment 5 is for rabbit anemia
Therapeutic effect is significantly better than comparative example 1, and it is right that the therapeutic effect of comparative example 2 and comparative example 3 is also significantly better than
Ratio embodiment 1, this shows, chlorophyll is ferrous, chrysophanic acid and icariin have significant synergism in terms for the treatment of anemia,
Therapeutic effect is better than being used alone chlorophyll ferrous iron.And the chlorophyll ferrous iron microcapsule described in embodiment of the present invention 1- embodiment 5
Better than comparative example 2 and comparative example 3, this shows, its release profiles in vivo is more conducive to the absorption of human body, medicine
Bioavailability is higher.
Described above not limitation of the present invention, the present invention is also not limited to the example above.The art common
Technical staff, in the essential scope of the present invention, the change made, remodeling, adds or replaces, and also should belong to the protection of the present invention
Scope.
Claims (7)
1. a kind of chlorophyll ferrous iron microcapsule is it is characterised in that its preparation technology specifically includes following steps：
1) prepare core material solution：Accurately weigh 20-30 weight portion chlorophyll ferrous iron, 10-20 weight portion chrysophanic acid and 10-20 weight
Part icariin, joins it in 200 parts of erithritols, stirs, obtain core material solution；
2) prepare wall material solution：Weigh guar gum and the 200-500 weight portion modified starch of 50-150 weight portion, plus 550-
1350 weight portion erithritol dissolvings, obtain wall material solution；
3) microcapsule preparation：Control core dry for the 15～28% of wall material solution dry matter weight, by core material solution and wall
Material solution is mixed to get dispersion liquid；Add in dispersion liquid the 0.5～1.5% of its weight two Plurol Oleique CC497s and 1～
The blended emulsifier of 1.4% sucrose fatty acid ester, after stirring 65～83 DEG C, 18～32MPa condition emulsified, spray dried
Dry, obtain final product chlorophyll ferrous iron microcapsule.
2. chlorophyll ferrous iron microcapsule according to claim 1 is it is characterised in that the dry of core material solution is by 25 weight
Part chlorophyll is ferrous, 15 weight portion chrysophanic acids and 15 weight portion icariin form.
3. chlorophyll according to claim 1 ferrous iron microcapsule it is characterised in that described wall material solution dry by
100 parts of guar gum and 350 parts of modified starch compositions.
4. chlorophyll according to claim 1 ferrous iron microcapsule is it is characterised in that described step 3) dispersion liquid in core
Dry is the 22% of wall material solution dry matter weight.
5. chlorophyll according to claim 1 ferrous iron microcapsule it is characterised in that in described blended emulsifier dimerization sweet
The addition of oily dioleate is the 1% of dispersion liquid weight, and the addition of described sucrose fatty acid ester is dispersion liquid weight
1.2%.
6. chlorophyll ferrous iron microcapsule according to claim 1 is it is characterised in that described emulsification condition is：Emulsifying temperature
Spend for 74 DEG C, Emulsification pressure be 20MPa.
7. chlorophyll ferrous iron microcapsule according to claim 1 is it is characterised in that the condition of described spray drying is：Enter
Air temperature is 160～180 DEG C, and leaving air temp is 85～105 DEG C, and atomizing pressure is 0.25～0.45MPa.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610736436.6A CN106377539A (en) | 2016-08-26 | 2016-08-26 | Chlorophyll ferrous microcapsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610736436.6A CN106377539A (en) | 2016-08-26 | 2016-08-26 | Chlorophyll ferrous microcapsule and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688723A (en) * | 2013-12-04 | 2015-06-10 | 鲁南制药集团股份有限公司 | Application of anhydroicaritin in preparation of medicine for treating anaemia |
-
2016
- 2016-08-26 CN CN201610736436.6A patent/CN106377539A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104688723A (en) * | 2013-12-04 | 2015-06-10 | 鲁南制药集团股份有限公司 | Application of anhydroicaritin in preparation of medicine for treating anaemia |
Non-Patent Citations (1)
| Title |
|---|
| 孟庆廷等: "壳聚糖- 海藻酸钠叶绿素亚铁微胶囊的制备及缓释性能研究", 《食品科学》 * |
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Application publication date: 20170208 |