CN1063485A - The manufacture method of 72-78% sodium lactate solution - Google Patents
The manufacture method of 72-78% sodium lactate solution Download PDFInfo
- Publication number
- CN1063485A CN1063485A CN 91100299 CN91100299A CN1063485A CN 1063485 A CN1063485 A CN 1063485A CN 91100299 CN91100299 CN 91100299 CN 91100299 A CN91100299 A CN 91100299A CN 1063485 A CN1063485 A CN 1063485A
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- China
- Prior art keywords
- solution
- sodium lactate
- lactate solution
- sodium
- manufacture method
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention provides a kind of high concentration acid sodium solution manufacture method, this method is selected the home-made chemical feedstocks for use, makes the lower concentration sodium lactate solution earlier, concentrates under vacuum then and makes 72～78% high concentration acid sodium solution.
Description
The invention belongs to field of medicine and chemical technology, a kind of manufacture method of high concentration acid sodium solution.
At present, the concentration of domestic sodium lactate solution product is 40%, does not still have the product of high concentration acid sodium solution, does not especially have 72～78% high concentration acid sodium solution product.So, in existing technical information and patent announcement, do not find the manufacture method of relevant high concentration acid sodium solution as yet.Because currently available products concentration is low, the property of medicine is poor, so clinical use needs a kind of high concentration acid sodium solution.
The purpose of this invention is to provide a kind of concentration height, the property of medicine is good, the manufacture method of 72～78% the high concentration acid sodium solution that cost is low.
Technical solution of the present invention is: at first content being about 55% sodium hydroxide solution, to join content be that reaction generates 40～50% lower concentration Sodium.alpha.-hydroxypropionate, reacts as follows in 50～60% the lactic acid:
And, add needle-use activated carbon in the reaction process, then with above lower concentration sodium lactate solution, under vacuum, concentrate, until obtaining high concentration acid sodium solution, its concentration is 72～78%.
Advantage of the present invention is: raw materials used is domestic raw material all, and technology is simple, and cost is low, and the sodium lactate solution concentration that makes can reach 72～78%, and medical effect is good, has changed the history that China can not produce this highly concentrated solution for a long time.
Narrate a concrete implementation method of the present invention below:
Get content and be 1000 milliliters of 50～60% qualified lactic acid, get content again and be about 55% sodium hydroxide solution, stir down and add slowly in the above-mentioned lactic acid solution, generate that pH value is about 7, content is 40～50% lower concentration sodium lactate solution, and adds the needle-use activated carbon that lactic acid production 0.05% is arranged approximately in reaction process.After vacuum filtration, continue to concentrate then, the vacuum tightness when concentrating is 450～550mmHg, and temperature is 70～80 ℃, is that 72-78% is qualified until concentration.
Its technological standard of the high concentration acid sodium solution that the present invention makes is as follows:
Proterties: the paste liquid of no color or smell
Validation test: be sodium salt, Lactated qualitative reaction
Fluidity (PH): 6.5～7.5(20% is 1 → 5)
Proportion: d
15 15: 1.37～1.43
Degree of staining: below the APHA20
Muriate: below 0.0013%
Vitriol: below 0.012%
Arsenic: below the 2PPM
Methyl alcohol: below 0.1%
Heavy metal: below the 10PPm
The volatile fat hydrochlorate: the foul smell of fat-free tart flavour takes place
Iron: below the 2ppm
Aldehyde: be not dun in 5 minutes
Malate, tartrate and Citrate trianion: liquid is clear and bright:
Content: 72～78%
Heat: must not have red precipitate to generate
︱ α |
25 D: L type 〉=42%
Claims (3)
1, a kind of manufacture method of high concentration acid sodium solution, the particularly mfg. method of 72～78% lactic acid solutions is characterized in that:
(1) content being about 55% sodium hydroxide solution, to join content be in 50～60% lactic acid, and reaction generates 40～50% lower concentration sodium lactate solution, and reaction formula is as follows:
And add needle-use activated carbon in the reaction process.
(2) with the sodium lactate solution of above lower concentration, under vacuum, concentrate, until the sodium lactate solution that obtains 72～78% high densitys.
2, the method for claim 1 is characterized in that: described lower concentration sodium lactate solution after vacuum filtration, reconcentration, the vacuum tightness when concentrating is 450～500mmHg, temperature is 70～80 ℃.
3, as claim 1,2 described methods, it is characterized in that: the add-on of described needle-use activated carbon is 0.05%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91100299 CN1063485A (en) | 1991-01-15 | 1991-01-15 | The manufacture method of 72-78% sodium lactate solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91100299 CN1063485A (en) | 1991-01-15 | 1991-01-15 | The manufacture method of 72-78% sodium lactate solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1063485A true CN1063485A (en) | 1992-08-12 |
Family
ID=4904544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 91100299 Pending CN1063485A (en) | 1991-01-15 | 1991-01-15 | The manufacture method of 72-78% sodium lactate solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1063485A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0789080A2 (en) | 1996-02-08 | 1997-08-13 | Gesellschaft für ökologische Technologie und Systemanalyse e.V. | Process for the preparation of organic aminium lactates and their use in the preparation of dilactide |
| CN1076725C (en) * | 1999-09-09 | 2001-12-26 | 湖北省广水市民族化工有限公司 | Process for preparing sodium lactate |
| CN102838476A (en) * | 2012-08-07 | 2012-12-26 | 蚌埠丰原涂山制药有限公司 | Preparation method for 60-65% sodium lactate solution |
-
1991
- 1991-01-15 CN CN 91100299 patent/CN1063485A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0789080A2 (en) | 1996-02-08 | 1997-08-13 | Gesellschaft für ökologische Technologie und Systemanalyse e.V. | Process for the preparation of organic aminium lactates and their use in the preparation of dilactide |
| CN1076725C (en) * | 1999-09-09 | 2001-12-26 | 湖北省广水市民族化工有限公司 | Process for preparing sodium lactate |
| CN102838476A (en) * | 2012-08-07 | 2012-12-26 | 蚌埠丰原涂山制药有限公司 | Preparation method for 60-65% sodium lactate solution |
| CN102838476B (en) * | 2012-08-07 | 2014-11-05 | 蚌埠丰原涂山制药有限公司 | Preparation method for 60-65% sodium lactate solution |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |