CN102838476B - Preparation method for 60-65% sodium lactate solution - Google Patents
Preparation method for 60-65% sodium lactate solution Download PDFInfo
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- CN102838476B CN102838476B CN201210279918.5A CN201210279918A CN102838476B CN 102838476 B CN102838476 B CN 102838476B CN 201210279918 A CN201210279918 A CN 201210279918A CN 102838476 B CN102838476 B CN 102838476B
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- sodium hydroxide
- lactic acid
- reaction mixture
- sodium
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- 239000008156 Ringer's lactate solution Substances 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 114
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 57
- 239000004310 lactic acid Substances 0.000 claims abstract description 28
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 28
- 239000011541 reaction mixture Substances 0.000 claims abstract description 20
- 239000007924 injection Substances 0.000 claims abstract description 11
- 238000002347 injection Methods 0.000 claims abstract description 11
- 239000000243 solution Substances 0.000 claims abstract description 10
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 claims description 24
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 18
- 238000004448 titration Methods 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 8
- 238000012360 testing method Methods 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 238000004364 calculation method Methods 0.000 claims description 4
- 238000005070 sampling Methods 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 2
- 238000004886 process control Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 17
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 abstract description 6
- 239000001540 sodium lactate Substances 0.000 abstract description 6
- 235000011088 sodium lactate Nutrition 0.000 abstract description 6
- 229940005581 sodium lactate Drugs 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- BMLSTPRTEKLIPM-UHFFFAOYSA-I calcium;potassium;disodium;hydrogen carbonate;dichloride;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Na+].[Na+].[Cl-].[Cl-].[K+].[Ca+2].OC([O-])=O BMLSTPRTEKLIPM-UHFFFAOYSA-I 0.000 abstract description 2
- 239000002778 food additive Substances 0.000 abstract 1
- 235000013373 food additive Nutrition 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 13
- NGSFWBMYFKHRBD-UHFFFAOYSA-N sodium;2-hydroxypropanoic acid Chemical compound [Na+].CC(O)C(O)=O NGSFWBMYFKHRBD-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 5
- 238000003918 potentiometric titration Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010027417 Metabolic acidosis Diseases 0.000 description 1
- 206010048218 Xeroderma Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 206010021198 ichthyosis Diseases 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention provides a preparation method for a sodium lactate solution with a mass concentration of 60-65%. The preparation method comprises the steps of 1) dropwise adding a sodium hydroxide solution into lactic acid; 2) stopping dropwise adding when a pH value of the solution is 5.-6.0 or 8.0-9.0; 3) precisely titrating a reaction mixture; and 4) adding sodium hydroxide or lactic acid to adjust the pH value of the reaction mixture to be 6.90-7.10. The sodium lactate solution prepared by the method has stable pH value, is easy to store, can be used for making sodium lactate injection and sodium lactate ringer's injection, and also can be used in the field of food additives. The concentration of the sodium lactate solution prepared by the method is 60%-65%, and is high in yield. The method is simple in process, is suitable for industrialized production, is easy to control the product quality, is high efficiency and stable.
Description
Technical field
The invention belongs to organic synthesis field, be specially the preparation method that a kind of concentration is the sodium lactate solution of 60-65%.
Background technology
Sodium.alpha.-hydroxypropionate (Sodium Lactate) chemical formula CH
3cHOHCOONa, colourless or be bordering on colourless syrupy liq, odorlessness, easily moisture absorption, can be miscible with water, ethanol, and it is neutral that its aqueous solution is.
Medicinal use:
(1) Sodium.alpha.-hydroxypropionate is applied to medical field mainly as injection, and its major function is for supplementing body fluid and mediator's cylinder electrolyte balance, and sodium lactate injection can be removed poisoning that the dehydration that causes because of diarrhoea and diabetes and gastritis cause.Sodium.alpha.-hydroxypropionate is used to supplement body fluid or ionogen in parenteral/solution, is widely used in for (CAPD) in nephropathy patient's continuous portable peritoneal dialysis solution and is used as dialyzate on common kidney machine;
(2) Sodium.alpha.-hydroxypropionate is as ionogen and dialysis thing in intravenous fluid, and thimerosal in intestines, gargles containing agent and bladder injectant etc.;
(3) Sodium.alpha.-hydroxypropionate is also widely used as the preparation of Green's liquid, makes injection liquid, as treatment metabolic acidosis;
(4) Sodium.alpha.-hydroxypropionate can be treated skin function disorder very effectively.As: the dry symptom of extreme that xeroderma etc. cause.Lactic acid and lactic acid salt have anti-microbial effect, and are applied in anti-acne product.They are also often combined with many other effective constituents, produce synergy.
The preparation method of Sodium.alpha.-hydroxypropionate has following several at present:
1. sodium hydroxide is added drop-wise to the Sodium.alpha.-hydroxypropionate of making lower concentration in lactic acid, and the Sodium.alpha.-hydroxypropionate concentration that this method is made, generally below 40%, also needs to concentrate, to obtain the high density Sodium.alpha.-hydroxypropionate of needs, has increased virtually production cost, has extended the production time;
2. also having a kind of general method is from the fermented liquid of calcium lactate, to extract and refine to obtain Sodium.alpha.-hydroxypropionate, and this method technique is loaded down with trivial details, and the production cycle is long, and yield is lower, is not optimal selection.
Summary of the invention
Based on the demand, the invention provides the preparation method that a kind of concentration is 60-65% sodium lactate solution.
The concrete technical scheme that realizes the object of the invention is:
A preparation method for mass concentration 60～65% sodium lactate solutions, comprises step:
1) sodium hydroxide solution is added dropwise in lactic acid;
2) during when pH is 5.0-6.0 or for 8.0-9.0, stop dripping;
3) accurate drop reaction mixture;
4) add sodium hydroxide or lactic acid, make reaction mixture pH value for 6.90-7.10.As step 2) control pH value 5.0-6.0, add sodium hydroxide, as step 2) control pH value is 8.0-9.0, adds lactic acid.
Wherein, described step 1) in, the concentration of sodium hydroxide solution is 45-50% mass ratio, and the concentration of lactic acid is 90-93% mass ratio.
Wherein, step 1), the mol ratio of sodium hydroxide and lactic acid is 1: 0.90-1.28.
Wherein, described step 1) in, the speed control reaction mixture temperature that drips sodium hydroxide by control is 60-75 ℃.Lactic acid and sodium hydroxide generation neutralization reaction are thermopositive reaction, drip sodium hydroxide speed soon reaction mixture temperature raise fast.During dropping, when temperature rises to upper temperature limit, stop dripping; When temperature drops to lowest temperature, accelerate the speed dripping.
Preferably, step 1) in, the speed control reaction mixture temperature that drips sodium hydroxide by control is 65-70 ℃.
Step 2), in, can use the pH value of pH test paper test reaction mixture.
Wherein, described step 3), the method for accurate titration is microtitrimetry or potentiometric titration.Microtitrimetry or potentiometric titration titrant consumption amount can be accurate to after radix point two.Step 4) sodium hydroxide adding in or the amount of lactic acid are determined by accurate titration results.It is to obtain according to the lactic acid of accurate titration sampling amount and consumption or amount of sodium hydroxide calculating.
Wherein, described step 4) also comprise the step of activated carbon decolorizing.
Wherein, the time of activated carbon decolorizing is 20-40min, and adding gac ratio is 1-2% mass ratio.
Wherein, described gac is injection active carbon, and the temperature of activated carbon decolorizing is 60-70 ℃.
Beneficial effect of the present invention is:
The sodium lactate solution pH that method of the present invention makes is stable, is easy to preserve, and can be used for making sodium lactate injection and sodium lactate ringer's injection and uses, and also can be used for foodstuff additive field; The sodium lactate solution concentration making according to present method is at 60%-65%, and yield is high.Present method technique is simple, is applicable to suitability for industrialized production, quality product easily controls, efficiently, stable.
Embodiment
Following preferred implementation is used for illustrating the present invention, but should not be construed as the restriction to scope of the present invention.
In embodiment, gac is purchased from Hangzhou Hang Mu Industrial Co., Ltd, and model is 732 type injection active carbons.The producer of the automatical potentiometric titrimeter that potentiometric titration adopts is Switzerland Wan Tong Instrument Ltd., model METROHM702.Sodium.alpha.-hydroxypropionate method for measurement of concentration is neutralisation.
Embodiment 1
Raw material:
For step 1) to 3) raw material comprise lactic acid (mass content 91.5%) 82g, sodium hydroxide (mass content 48%) is prepared 69.4g altogether, for the injection active carbon 1.8g decolouring.
Operation:
1) get 82g lactic acid and be placed in three-necked bottle, sodium hydroxide is slowly splashed into stirring;
2) dropping process should be controlled temperature of reaction at 65-70 ℃; When temperature rises to 70 ℃, stop dripping, when temperature drops to 65 ℃, accelerate the speed dripping.The about 2ml/min of rate of addition.
3) pH test paper is presented at 5.4 and stops dripping, and at this moment consumes sodium hydroxide 55g.
4) after stirring fully, get 4g solution boil rear with the accurate titration of 0.1mol/L NaOH, the phenolphthalein agent of giving instruction; Microburette is used in titration, stops titration during to phenolphthalein variable color, and accurate recording consumes NaOH and measures, and consumes altogether 0.515ml, and calculates accordingly 133g reaction mixture and need to add sodium hydroxide 0.0017mol.Because of phenolphthalein variable color when the pH=8.2, therefore deduct half amount (0.02ml) when calculation consumption NaOH measures, calculate.Because lactic acid is weak acid, and sodium hydroxide is highly basic, and after sampling, boiling is guarantee drop reaction fully and stablize.
5) according to accurate titration results, calculate, in reaction mixture, add 1.7ml 1mol/LNaOH, obtaining reaction mixture pH value is 7.02;
6) pH adds 1.8g injection active carbon decolouring 30min after stable, filters to obtain the content product that is 61.8%.With respect to lactic acid meter, yield is 97.0%.This product pH remains 7.02, and room temperature is placed nothing muddiness after 6 months, and color is pure, and pH value is constant.
Embodiment 2
Raw material:
For step 1) to 3) raw material: lactic acid (content 91.5%) 85g, sodium hydroxide (content 48%) is prepared 72g altogether; For the gac 1.9g decolouring.
Operation:
1) get 85g lactic acid and be placed in three-necked bottle, sodium hydroxide is slowly splashed into stirring;
2) dropping process should be controlled its temperature of reaction well at 65-70 ℃;
3) pH test paper is presented at 8.8, stops dripping, and now consumes sodium hydroxide 70g,
4) after stirring fully, get 3.5g solution and boil afterwards with the accurate titration of 0.1mol/L HCl, the phenolphthalein agent of giving instruction, stops titration, the hydrochloric acid content that record consumes during phenolphthalein variable color; (because of phenolphthalein variable color when the pH=8.2, therefore additionally add again first staetometer when calculation consumption hydrochloric acid content, calculating)
5) to adding 1.4ml 1mol/L breast acid for adjusting pH value in reaction mixture, be 6.95;
6) pH adds 1.9g activated carbon decolorizing 30min after stable, filters to obtain the content product that is 61.6%.With respect to lactic acid yield, be 96.5%.
Embodiment 3
Raw material:
For step 1) to 3) lactic acid (content 90%) 81g, sodium hydroxide (content 45%) is prepared 72g altogether, for the medicinal carbon 3.0g decolouring.
Operation:
1) get 85g lactic acid and be placed in three-necked bottle, sodium hydroxide is slowly splashed into stirring;
2) dropping process should be controlled reaction mixture 65-70 ℃;
3) pH test paper is presented at 8.8, stops dripping;
4) after stirring fully, get 3.5g solution and boil afterwards with the accurate titration of 0.1mol/L HCl, the phenolphthalein agent of giving instruction, stops titration, the hydrochloric acid content that record consumes during phenolphthalein variable color; (note: because of phenolphthalein variable color when the pH=8.2, calculate therefore additionally add again first staetometer when calculation consumption hydrochloric acid content)
5) to adding 1.4ml 1mol/L breast acid for adjusting pH value in reaction mixture, be 6.95;
6) pH adds activated carbon decolorizing 40min after stable, and during decolouring, temperature remains 70 ℃, filters to obtain the content sodium lactate solution that is 61.6%.With respect to lactic acid yield, be 95.9%.
Embodiment 4
Raw material:
For step 1) to 3) lactic acid (content 93%) 87g, sodium hydroxide (content 50%) is prepared 72g altogether, for the gac 1.59g decolouring.
Operation:
1) get 85g lactic acid and be placed in three-necked bottle, sodium hydroxide is slowly splashed into stirring;
2) dropping process should be controlled reaction mixture 60-70 ℃;
3) pH test paper is presented at 8.8, stops dripping;
4) after stirring fully, get 3.5g solution and boil the rear 0.1mol/L of using HCl potentiometric titration, during pH value 7.0, stop titration, the hydrochloric acid content that record consumes;
5) in reaction mixture, add 1.4ml 1mol/L lactic acid, obtaining reaction mixture pH value is 6.95;
6) pH adds activated carbon decolorizing 40min after stable, and during decolouring, temperature remains 70 ℃, filters to obtain the content sodium lactate solution that is 61.6%.With respect to lactic acid yield, be 95.1%.
Claims (1)
1. a preparation method for mass concentration 60～65% sodium lactate solutions, comprises step:
Raw material:
For step 1) to 3) raw material comprise the lactic acid 82g of mass content 91.5%, mass content 48% sodium hydroxide is prepared 69.4g altogether, for the injection active carbon 1.8g decolouring;
Operation:
1) get 82g lactic acid and be placed in three-necked bottle, sodium hydroxide is slowly splashed into stirring;
2) drip process control temperature of reaction at 65-70 ℃; When temperature rises to 70 ℃, stop dripping, when temperature drops to 65 ℃, accelerate the speed of dropping, rate of addition 2ml/min;
3) pH test paper is presented at 5.4 and stops dripping, and at this moment consumes sodium hydroxide 55g;
4) after stirring fully, get 4g solution boil rear with the accurate titration of 0.1mol/L NaOH, the phenolphthalein agent of giving instruction; Microburette is used in titration, stops titration during to phenolphthalein variable color, and accurate recording consumes NaOH and measures, and consumes altogether 0.515ml, and calculates accordingly 133g reaction mixture and need to add sodium hydroxide 0.0017mol; Because of phenolphthalein variable color when the pH=8.2, therefore deduct half amount when calculation consumption NaOH measures, 0.02ml, calculates; Because lactic acid is weak acid, and sodium hydroxide is highly basic, and after sampling, boiling is guarantee drop reaction fully and stablize;
5) according to accurate titration results, calculate, in reaction mixture, add 1.7ml1mol/L NaOH, obtaining reaction mixture pH value is 7.02;
6) pH adds 1.8g injection active carbon decolouring 30min after stable, filters to obtain the content product that is 61.8%.
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| CN102838476B true CN102838476B (en) | 2014-11-05 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105218349A (en) * | 2015-09-11 | 2016-01-06 | 安徽丰原马鞍山生物化学有限公司 | A kind of production method of L Sodium.alpha.-hydroxypropionate |
| CN109265338A (en) * | 2018-10-09 | 2019-01-25 | 武汉三江航天固德生物科技有限公司 | The production method of medical sodium lactate solution |
| CN110272340B (en) * | 2019-07-19 | 2020-07-07 | 临沂艾德森生物科技有限公司 | Sodium lactate decoloring process and application thereof |
| CN115737548B (en) * | 2022-11-21 | 2024-12-27 | 四川汇宇制药股份有限公司 | A kind of preparation method of famotidine injection |
| CN116041173A (en) * | 2022-12-29 | 2023-05-02 | 青岛九泰生物科技有限公司 | Process for producing and preparing sodium lactate powder |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063485A (en) * | 1991-01-15 | 1992-08-12 | 王克 | The manufacture method of 72-78% sodium lactate solution |
| CN101018756A (en) * | 2004-06-17 | 2007-08-15 | 普拉克生化公司 | Process for the preparation of lactic acid or lactate from a magnesium lactate comprising medium |
| CN101265179A (en) * | 2008-04-18 | 2008-09-17 | 南京工业大学 | A kind of purification process of lactate |
| CN102050723A (en) * | 2009-10-27 | 2011-05-11 | 中国石油化工股份有限公司 | Method for producing sodium lactate |
-
2012
- 2012-08-07 CN CN201210279918.5A patent/CN102838476B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063485A (en) * | 1991-01-15 | 1992-08-12 | 王克 | The manufacture method of 72-78% sodium lactate solution |
| CN101018756A (en) * | 2004-06-17 | 2007-08-15 | 普拉克生化公司 | Process for the preparation of lactic acid or lactate from a magnesium lactate comprising medium |
| CN101265179A (en) * | 2008-04-18 | 2008-09-17 | 南京工业大学 | A kind of purification process of lactate |
| CN102050723A (en) * | 2009-10-27 | 2011-05-11 | 中国石油化工股份有限公司 | Method for producing sodium lactate |
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