CN106344206A - Absorbable anti-adhesion hernia repairing patch and preparation method thereof - Google Patents
Absorbable anti-adhesion hernia repairing patch and preparation method thereof Download PDFInfo
- Publication number
- CN106344206A CN106344206A CN201510408658.0A CN201510408658A CN106344206A CN 106344206 A CN106344206 A CN 106344206A CN 201510408658 A CN201510408658 A CN 201510408658A CN 106344206 A CN106344206 A CN 106344206A
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- China
- Prior art keywords
- mesh sheet
- lower floor
- slow release
- absorbable
- infectives
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Abstract
The invention discloses an absorbable anti-adhesion hernia repairing patch and a preparation method thereof. The repairing patch comprises an upper-layer mesh and a lower-layer mesh, an arc-shaped connecting body is arranged between the upper-layer mesh and the lower-layer mesh, the edge of the arc-shaped connecting body is connected with the upper-layer mesh through non-absorbable lines, and the bottom of the arc-shaped connecting body is connected with the lower-layer mesh through absorbable lines; the lower-layer mesh and the arc-shaped connecting body are both made from an absorbable material; the lower-layer mesh is provided with multiple slow-release anti-infection layers which are distributed in a concentric annulus mode, and the circle center of the concentric annulus coincides with the center of the lower-layer mesh; the slow-release anti-infection layers are formed by applying slow-release anti-infection drugs on the lower-layer mesh and then drying the drugs at normal temperature. The arc-shaped connecting body and the lower-layer mesh are both made from the biodegradable material, can be slowly metabolized in a human body, is nontoxic and harmless and can effectively isolate the wound surface from visceral organs, the condition that the wound surface directly makes contact with the peripheral tissues in the healing process is avoided, and adhesion is effectively prevented.
Description
Technical field
The present invention relates to a kind of hernia patch, especially relate to a kind of hernia patch of absorbent antiseize and its
Preparation method.
Background technology
Abdominal hernia is caused by abdominal viscera goes out via stock ventral groove rostrum, and (male is about the sickness rate height of abdominal hernia
27%, women is about 3%), and the various age all it may happen that, traditional restorative procedure due to have easy recurrence,
Repair time length, postoperative pain etc. determine and be not used, the Hammock Method operation using sticking patch mode should
Transport and give birth to.Tension-free Hernioplasty is come repairing hernia breach with sticking patch, it is to avoid traditional herniorrhaphy
Postoperative pain, the shortcoming of easily recurrence.The sticking patch that clinically commonly used polyester, polypropylene material are made at present.
Propene polymer patch has excellent chemical stability and histocompatibility, and fibrous tissue can be promoted to be formed,
It has that anti-infection property is good, intensity is high, biologically inert, processing ease, be unlikely to deform, cheap etc. excellent
Point.But propene polymer patch does not possess anti function, clinically had implantation abdominal cavity suffer from abdominal pain, intestinal
The case of the complication such as fistula, material corrosion internal organs.For this reason, design one kind is effectively isolated abdominal viscera and is repaiied with hernia
Sticking patch, and to have the hernia patch of preventing adhesiving effect be necessary.
Content of the invention
It is an object of the present invention to provide a kind of hernia patch of absorbent antiseize and preparation method thereof, existing to solve
After having herniorrhaphy hernia patch can with visceral adhesion, lead to multiple complications, increase the skill such as patient's misery
Art problem.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is: a kind of absorbent antiseize
Hernia patch, including upper strata mesh sheet, lower floor's mesh sheet, is provided with arc between described upper strata mesh sheet and lower floor's mesh sheet
Shape connector, the edge of described arc connector is connected by non-absorbable thread with upper strata mesh sheet, and arc connects
Body bottom is connected by absorbable thread with lower floor mesh sheet；Described lower floor mesh sheet, arc connector are absorbable
Material；Multiple slow release infection layers are provided with described lower floor mesh sheet, slow release infection layer divides in donut
Cloth, the annulus center of circle and lower floor's mesh sheet center superposition；Described slow release infection layer is by applying in lower floor's mesh sheet
Cloth slow release anti-infectives, drying forms.
Preferably, the material of described upper strata mesh sheet is single fiber polypropylene or expanded polytetrafluoroethylsealing.
Preferably, the material of described lower floor mesh sheet, arc connector is poly- carboxyl acetic acid, polylactic
At least one in acetic acid, polylactic acid (pla).
Preferably, described absorbable thread is made up of the gutstring of chitin or bag chitin film.
Preferably, described slow release anti-infectives, including slow releasing agent, anti-infectives；Slow releasing agent is poly-
Lactic acid (pla), polyglycolic acid, Polyethylene Glycol (peg), Polyhydroxybutyrate-co-hydroxyvalerate copolymer
(phbv), fibrin gel, collagen sponge, chitosan, at least one in gelatin；Anti-infective
Thing is aminoglycoside medicaments: streptomycin, neomycin, sisomicin；Quinolones: Moxifloxacin,
Clinafloxacin, Gemifloxacin；Sugared peptide medicament: at least one in vancomycin, teicoplanin.
A kind of method of the hernia patch preparing above-mentioned absorbent antiseize, comprises the following steps:
A. by the aqueous solution of anti-infectives, it is added in organosol or the aqueous solution of slow releasing agent, by stirring
Mix mixing, medicine is wrapped up by slow releasing agent, prepared slow release anti-infectives；
B. slow release anti-infectives are sprayed in lower floor's mesh sheet, after being dried, form annular slow release infection layer；
C. with absorbable thread, lower floor's mesh sheet is sutured with arc connector bottom；
D. with non-absorbable thread, the edge of arc connector is sutured with upper wire piece, you can be obtained absorbable anti-
The hernia patch of adhesion.
The structure that the present invention is combined with arc connector, lower floor's mesh sheet using upper strata mesh sheet, upper strata mesh sheet is pacified
Entirely, nontoxic, histocompatibility is good, can maintain higher tension force and abdominal part compliance, granulation tissue progress
The gap of upper strata mesh sheet, can increase the intensity of repairing, and arc connects physical ability and is filled in the duct of hernia and abdomen
Film is fitted, and is easy to the regeneration of defect, lower floor's mesh sheet uses absorbable compound mesh sheet, in lower floor's mesh sheet
Also it is coated with the slow release infection layer that slow releasing agent and anti-infectives are composited, can effectively avoid postoperative
Wound infection；Arc connector and lower floor's mesh sheet are all Biodegradable materials, can lentamente generation in human body
Thank, nontoxic, can effectively wound surface be isolated with internal organs, so as not in agglutination wound surface with
Surrounding tissue directly contact, effectively prevents the generation of adhesion.The hernia of the absorbent antiseize of the present invention is repaired
Piece has good infection and preventing adhesiving effect, is very suitable for herniorrhaphy, can reduce operation concurrent
Disease, mitigates patient painful.
Brief description
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to enforcement
Example or description of the prior art in required use accompanying drawing be briefly described it should be apparent that, below describe
In accompanying drawing be only some embodiments of the present invention, for those of ordinary skill in the art, do not paying
On the premise of going out creative work, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of the hernia patch of absorbent antiseize；
Fig. 2 is the top view of Fig. 1.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clearly
Chu, it is fully described by it is clear that described embodiment is only a part of embodiment of the present invention, rather than
Whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art are not making creation
Property work under the premise of the every other embodiment that obtained, broadly fall into the scope of protection of the invention.
Fig. 1 is the structural representation of the hernia patch of absorbent antiseize, and Fig. 2 is the top view of Fig. 1.
As seen from the figure, the hernia patch of this absorbent antiseize, including upper strata mesh sheet 1, lower floor's mesh sheet 2, arc
Shape connector 3 etc..It is provided with arc connector 3, arc connector between upper strata mesh sheet 1 and lower floor's mesh sheet 2
3 edge is connected by non-absorbable thread 4 with upper strata mesh sheet 1, arc connector 3 bottom and lower floor's mesh sheet 2
Connected by absorbable thread 5.The material of upper strata mesh sheet 1 is single fiber polypropylene or expanded polytetrafluoroethylsealing.
Lower floor's mesh sheet 2, arc connector 3 are absorbable material.Lower floor's mesh sheet 2, arc connector 3
Material is poly- carboxyl acetic acid, polylactic-co-glycolic acid, at least one in polylactic acid (pla).Lower floor's mesh sheet
Be provided with multiple slow release infection layers 6 on 2, slow release infection layer 6 be in donut be distributed, the annulus center of circle with
Lower floor's mesh sheet 2 center superposition.Slow release infection layer 6 is by being coated with slow release infection in lower floor's mesh sheet 2
Medicine, drying forms.
Above-mentioned absorbable thread 5 is made up of the gutstring of chitin or bag chitin film.
Above-mentioned slow release anti-infectives, including slow releasing agent, anti-infectives；Slow releasing agent be polylactic acid (pla),
Polyglycolic acid, Polyethylene Glycol (peg), Polyhydroxybutyrate-co-hydroxyvalerate copolymer (phbv), fiber
At least one in protein gel, collagen sponge, chitosan, gelatin, anti-infectives are aminoglycoside
Class medicine: streptomycin, neomycin, sisomicin；Quinolones: Moxifloxacin, clinafloxacin,
Gemifloxacin；Sugared peptide medicament: at least one in vancomycin, teicoplanin.
The method preparing the hernia patch of above-mentioned absorbent antiseize, comprises the following steps:
A. by the aqueous solution of anti-infectives, it is added in organosol or the aqueous solution of slow releasing agent, by stirring
Mix mixing, medicine is wrapped up by slow releasing agent, prepared slow release anti-infectives；
B. slow release anti-infectives are sprayed in lower floor's mesh sheet, after being dried, form annular slow release infection layer；
C. with absorbable thread, lower floor's mesh sheet is sutured with arc connector bottom；
D. with non-absorbable thread, the edge of arc connector is sutured with upper wire piece, you can be obtained absorbable anti-
The hernia patch of adhesion.
The following is several embodiments of the hernia patch of this absorbent antiseize.
Embodiment 1:
A kind of method of the hernia patch preparing absorbent antiseize, comprises the following steps:
S1. anti-infectives clinafloxacin and water are made clinafloxacin aqueous solution by the part by weight of 1:2, will
Clinafloxacin aqueous solution is added in slow releasing agent chitosan aqueous solution, is mixed by stirring, medicine is by slow release
Agent is wrapped up, prepared slow release anti-infectives, and the medicament contg of slow release anti-infectives is 50mg/ml；
S2. slow release anti-infectives are sprayed in lower floor's mesh sheet of poly- carboxyl acetic acid material, after being dried, form ring
Shape slow release infection layer；
S3. with absorbable thread, lower floor's mesh sheet is sutured with the arc connector bottom of poly- carboxyl acetic acid material；
S4. with non-absorbable thread, the upper wire piece at the edge of arc connector and polypropylene material is sutured, you can
The hernia patch of prepared absorbent antiseize.
Embodiment 2:
A kind of method of the hernia patch preparing absorbent antiseize, comprises the following steps:
S1. anti-infectives vancomycin and water are made vancomycin aqueous solution by the part by weight of 1:2, will
Vancomycin aqueous solution is added in the organosol of slow releasing agent Polyethylene Glycol, is mixed by stirring, medicine quilt
Slow releasing agent wraps up, prepared slow release anti-infectives, and the medicament contg of slow release anti-infectives is 65mg/ml；
S2. slow release anti-infectives are sprayed in lower floor's mesh sheet of polylactic acid material, form annular after being dried slow
Release infection layer；
S3. with absorbable thread, the arc connector bottom of lower floor's mesh sheet and poly- carboxyl acetic acid material is sutured；
S4. with non-absorbable thread, the upper wire piece at the edge of arc connector and polypropylene material is sutured, you can
The hernia patch of prepared absorbent antiseize.
Embodiment 3:
A kind of method of the hernia patch preparing absorbent antiseize, comprises the following steps:
S1. anti-infectives neomycin and water are made neomycin aqueous solution by the part by weight of 1:3, will be newly mould
Plain aqueous solution is added in the organosol of slow releasing agent polylactic acid, is mixed by stirring, medicine is by slow releasing agent bag
Wrap up in, prepared slow release anti-infectives, the medicament contg of slow release anti-infectives is 80mg/ml；
S2. slow release anti-infectives are sprayed in lower floor's mesh sheet of polylactic-co-glycolic acid material, shape after being dried
Circularize slow release infection layer；
S3. with absorbable thread, the arc connector bottom of lower floor's mesh sheet and polylactic-co-glycolic acid material is sutured；
S4. with non-absorbable thread, the upper wire piece at the edge of arc connector and polypropylene material is sutured, you can
The hernia patch of prepared absorbent antiseize.
In the present invention, lower floor's mesh sheet uses absorbable compound mesh sheet, lower floor's mesh sheet is also coated with slow
Release the slow release infection layer that agent and anti-infectives are composited, can effectively avoid postoperative wound infection；
Arc connector and lower floor's mesh sheet are all Biodegradable materials, can be lentamente in human body metabolism, nontoxic nothing
Wound surface can be isolated, in order to avoid wound surface is straight with surrounding tissue in agglutination by evil effectively with internal organs
Contact, effectively prevents the generation of adhesion.
Finally it is pointed out that above specific embodiment is only the more representational example of the present invention.Obviously,
The invention is not restricted to above-mentioned specific embodiment, can also have many deformation.Every technology according to the present invention
Any simple modification, equivalent variations and modification that essence is made to above specific embodiment, are all considered as belonging to
In protection scope of the present invention.
Claims (6)
1. a kind of hernia patch of absorbent antiseize, including upper strata mesh sheet, lower floor's mesh sheet, is characterized in that on described
It is provided with arc connector, the edge of described arc connector and upper strata mesh sheet between layer mesh sheet and lower floor's mesh sheet
Connected by non-absorbable thread, arc connector bottom is connected by absorbable thread with lower floor mesh sheet；Under described
Layer mesh sheet, arc connector are absorbable material；Multiple slow release infection are provided with described lower floor mesh sheet
Layer, slow release infection layer is in donut distribution, the annulus center of circle and lower floor's mesh sheet center superposition；Described slow release
Infection layer is by being coated with slow release anti-infectives in lower floor's mesh sheet, and drying forms.
2. the hernia patch of absorbent antiseize according to claim 1, is characterized in that described upper strata mesh sheet
Material is single fiber polypropylene or expanded polytetrafluoroethylsealing.
3. the hernia patch of absorbent antiseize according to claim 1, it is characterized in that described lower floor mesh sheet,
The material of arc connector is poly- carboxyl acetic acid, polylactic-co-glycolic acid, in polylactic acid (pla) at least one
Kind.
4. the hernia patch of absorbent antiseize according to claim 1, is characterized in that described absorbable thread is
The gutstring of chitin or bag chitin film is made.
5. the hernia patch of absorbent antiseize according to claim 1, is characterized in that described slow release infection
Medicine, including slow releasing agent, anti-infectives；Slow releasing agent is polylactic acid (pla), polyglycolic acid, poly- second two
Alcohol (peg), Polyhydroxybutyrate-co-hydroxyvalerate copolymer (phbv), fibrin gel, collagen sea
At least one in silk floss, chitosan, gelatin；Anti-infectives are aminoglycoside medicaments: streptomycin,
Neomycin, sisomicin；Quinolones: Moxifloxacin, clinafloxacin, Gemifloxacin；Glycopeptide class
Medicine: at least one in vancomycin, teicoplanin.
6. a kind of method of the hernia patch preparing absorbent antiseize, comprises the following steps:
A. by the aqueous solution of anti-infectives, it is added in organosol or the aqueous solution of slow releasing agent, by stirring
Mix mixing, medicine is wrapped up by slow releasing agent, prepared slow release anti-infectives；
B. slow release anti-infectives are sprayed in lower floor's mesh sheet, after being dried, form annular slow release infection layer；
C. with absorbable thread, lower floor's mesh sheet is sutured with arc connector bottom；
D. with non-absorbable thread, the edge of arc connector is sutured with upper wire piece, you can be obtained absorbable anti-
The hernia patch of adhesion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510408658.0A CN106344206A (en) | 2015-07-14 | 2015-07-14 | Absorbable anti-adhesion hernia repairing patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510408658.0A CN106344206A (en) | 2015-07-14 | 2015-07-14 | Absorbable anti-adhesion hernia repairing patch and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106344206A true CN106344206A (en) | 2017-01-25 |
Family
ID=57842067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510408658.0A Pending CN106344206A (en) | 2015-07-14 | 2015-07-14 | Absorbable anti-adhesion hernia repairing patch and preparation method thereof |
Country Status (1)
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| CN (1) | CN106344206A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109875722A (en) * | 2019-02-03 | 2019-06-14 | 北京纺织科学研究所有限公司 | A kind of compound hernia patch and its manufacturing method |
| CN111714707A (en) * | 2019-03-19 | 2020-09-29 | 陕西佰傲再生医学有限公司 | Anti-infection anti-adhesion composite hernia repair patch and preparation method thereof |
| CN111938864A (en) * | 2020-08-20 | 2020-11-17 | 日照天一生物医疗科技有限公司 | Absorbable self-adhesive hernia repair patch and preparation method thereof |
-
2015
- 2015-07-14 CN CN201510408658.0A patent/CN106344206A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109875722A (en) * | 2019-02-03 | 2019-06-14 | 北京纺织科学研究所有限公司 | A kind of compound hernia patch and its manufacturing method |
| CN111714707A (en) * | 2019-03-19 | 2020-09-29 | 陕西佰傲再生医学有限公司 | Anti-infection anti-adhesion composite hernia repair patch and preparation method thereof |
| CN111938864A (en) * | 2020-08-20 | 2020-11-17 | 日照天一生物医疗科技有限公司 | Absorbable self-adhesive hernia repair patch and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170125 |