CN106344039A - Weak signal precision measurement device and method of bio-sensors - Google Patents
Weak signal precision measurement device and method of bio-sensors Download PDFInfo
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- CN106344039A CN106344039A CN201610741562.0A CN201610741562A CN106344039A CN 106344039 A CN106344039 A CN 106344039A CN 201610741562 A CN201610741562 A CN 201610741562A CN 106344039 A CN106344039 A CN 106344039A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- G—PHYSICS
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- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
- G05B19/042—Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors
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- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03F—AMPLIFIERS
- H03F1/00—Details of amplifiers with only discharge tubes, only semiconductor devices or only unspecified devices as amplifying elements
- H03F1/30—Modifications of amplifiers to reduce influence of variations of temperature or supply voltage or other physical parameters
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- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03F—AMPLIFIERS
- H03F3/00—Amplifiers with only discharge tubes or only semiconductor devices as amplifying elements
- H03F3/45—Differential amplifiers
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- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03F—AMPLIFIERS
- H03F3/00—Amplifiers with only discharge tubes or only semiconductor devices as amplifying elements
- H03F3/45—Differential amplifiers
- H03F3/45071—Differential amplifiers with semiconductor devices only
- H03F3/45076—Differential amplifiers with semiconductor devices only characterised by the way of implementation of the active amplifying circuit in the differential amplifier
- H03F3/45475—Differential amplifiers with semiconductor devices only characterised by the way of implementation of the active amplifying circuit in the differential amplifier using IC blocks as the active amplifying circuit
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Abstract
The invention discloses a weak signal precision measurement device of bio-sensors and a weak signal precision measurement method thereof. The weak signal precision measurement device comprises a first differential amplifier, a second differential amplifier, a third differential amplifier, an ADC (Analog to Digital Converter) amplifier chip and a single chip. The first differential amplifier acquires first weak signals from a first bio-sensor and acquires second micro signals from a second bio-sensor to obtain first differential signals through differential operation amplification. The second differential amplifier acquires third weak signals from a third bio-sensor and acquires fourth micro signals from a fourth bio-sensor to obtain second differential signals through differential operation amplification. First differential signals and second differential signals are conducted for difference operation and are amplified to obtain measured characteristic signals. By the ADC amplifier chip, characteristic signals are amplified, conducted for digital-to-analogue conversion and then output to the single chip for measuring and analyzing signals. By the device and the method, weak characteristic electrical signals can be measured and measurement accuracy of weak signals is improved.
Description
Technical field
The present invention relates to the technical field of signal measurement, the micro-signal accurate measurement dress of more particularly, to a kind of biosensor
Put and method.
Background technology
Microsignal amplification is signal measurement and the basis of metering, for the tiny signal within 50mv it is impossible to directly use
In chips such as ad samplings it is necessary to just can measure after being amplified signal by amplifying circuit.Micro-signal measurement is often signal
Difficult point in measurement, the tiny signal within 50mv is difficult to be obtained by circuitry for signal measurement detection.Usually, biosensor
The bioelectrical signals that (such as sign monitors blood glucose in biosensor, body temperature, heart rate biosensor etc.) exports all compare
Faint, due to tested bioelectrical signals very weak it is therefore necessary to could survey after amplifying circuit is by tested amplifier of creatures' physical electric signals
Measure.When amplifying circuit in existing signal measurement device is amplified to small-signal, amplifying circuit often produces temperature
Spend drift phenomenon and cause stronger signal to disturb, lead to faint bioelectrical signals then can be submerged among interference signal,
Therefore lead to cause the measurement result of faint tested bioelectrical signals inaccurate, or even cannot measure faint tested at all
Bioelectrical signals.
Content of the invention
Present invention is primarily targeted at a kind of micro-signal precision measurement apparatus of biosensor and method are provided it is intended to
Solve to cause the inaccurate problem of measurement result when measuring small-signal because of the temperature drift of amplifying circuit generation.
For achieving the above object, the invention provides a kind of micro-signal precision measurement apparatus of biosensor, Yi Zhongsheng
The micro-signal precision measurement apparatus of thing sensor, this micro-signal precision measurement apparatus is connected with the first biosensor, the second life
Thing sensor, the 3rd biosensor and the 4th biosensor are it is characterised in that described micro-signal precision measurement apparatus bag
Include the first difference amplifier, the second difference amplifier, the 3rd difference amplifier, adc amplification chip and single-chip microcomputer, described first
Difference amplifier and the second difference amplifier all include two first resistors and two second resistances, described 3rd differential amplification
Device includes two 3rd resistors and two the 4th resistance, wherein:
Described first difference transport and placing device is used for obtaining the first micro-signal and from the second bio-sensing from the first biosensor
Device obtains the second micro-signal, will be poor by the amplification of this first difference transport and placing device to the first micro-signal and the second micro-signal
Partite transport is calculated and is amplified and obtains the first differential signal, and the amplification of described first difference amplifier is equal in the first difference amplifier
Second resistance and first resistor resistance value ratio；
Described second difference amplifier is used for obtaining the 3rd micro-signal and from the 4th bio-sensing from the 3rd biosensor
Device obtains the 4th micro-signal, will be poor by the amplification of this second difference amplifier to the 3rd micro-signal and the 4th micro-signal
Partite transport is calculated and is amplified and obtains the second differential signal, and the amplification of described second difference amplifier is equal to the first difference amplifier
Amplification；
Described 3rd difference amplifier is used for for the first differential signal and the second differential signal passing through the 3rd differential amplification
The amplification of device carries out calculus of differences amplifying and obtains measuring characteristic signal, amplification of described 3rd difference amplifier etc.
The ratio of the resistance value of the 4th resistance in the 3rd difference amplifier and 3rd resistor；
Described adc amplification chip includes amplifying circuit chip and adc circuit chip, and described amplifying circuit chip is used for will
Described measurement characteristic signal exports to adc circuit chip after the amplification of this amplifying circuit chip carries out signal amplification,
The amplification of described amplifying circuit chip is the intrinsic particular value of this amplifying circuit chip；
Wherein, the temperature coefficient of the first difference amplifier is equal to the temperature coefficient of second resistance and the temperature system of first resistor
The ratio of number, the temperature coefficient of the second difference amplifier is equal with the temperature coefficient of the first difference amplifier, the 3rd differential amplification
The temperature coefficient of device is equal to the ratio of the temperature coefficient of the 4th resistance and the temperature coefficient of 3rd resistor, the first difference amplifier
The product of temperature coefficient of temperature coefficient and the 3rd difference amplifier is equal in magnitude with the temperature coefficient of amplifying circuit chip and accords with
Number contrary.
Further, the first input end of described first difference amplifier connects to the first biosensor, the first difference
Second input of amplifier connects to the second biosensor；The first input end of described second difference amplifier connects to
Three biosensors, the second input of the second difference amplifier connects to the 4th biosensor；Described first differential amplification
The outfan of device connects to the first input end of the 3rd difference amplifier, and the outfan of the second difference amplifier connects to the 3rd poor
Divide the second input of amplifier；The outfan of described 3rd difference amplifier connects to the input of described amplifying circuit chip
End, the outfan of described amplifying circuit chip connects to the input of adc circuit chip, the outfan of described adc circuit chip
Connect to described single-chip microcomputer.
Further, described first difference amplifier also includes first crystal audion, and the first difference amplifier is wherein
One first resistor is connected serially to the first input end of first crystal audion, other in which first electricity of the first difference amplifier
Resistance is connected serially to the second input of first crystal audion, and one end of one of second resistance of the first difference amplifier connects
To the first input end of first crystal audion and the other end of this second resistance connects to the outfan of first crystal audion,
One end of the other in which second resistance of the first difference amplifier connects the second input to first crystal audion and is somebody's turn to do
The other end of second resistance connects to earth lead.
Further, described second difference amplifier also includes first crystal audion, and the second difference amplifier is wherein
One first resistor is connected serially to the first input end of first crystal audion, other in which first electricity of the second difference amplifier
Resistance is connected serially to the second input of first crystal audion, and one end of one of second resistance of the second difference amplifier connects
To the first input end of first crystal audion and the other end of this second resistance connects to the outfan of first crystal audion,
One end of the other in which second resistance of the second difference amplifier connects the second input to first crystal audion and is somebody's turn to do
The other end of second resistance connects to earth lead.
Further, described 3rd difference amplifier also includes the second crystal triode, one of 3rd resistor series connection
To the first input end of the second crystal triode, other in which 3rd resistor is connected serially to the second input of the second crystal triode
End, one end of one of them the 4th resistance connects the other end of first input end to the second crystal triode and the 4th resistance
Connect to the outfan of the second crystal triode, one end of other in which the 4th resistance connects to the of the second crystal triode
The other end of two inputs and the 4th resistance connects to earth lead.
Further, described first biosensor is used for sensing first wave length Infrared irradiation in target detection object
The first micro-signal producing, the second biosensor is used for sensing second wave length Infrared irradiation and produces on target detection object
The second micro-signal, the 3rd biosensor is used for sensing the 3rd IR wavelengths and is radiated at the produce on target detection object
Three micro-signals, it is micro- that the 4th biosensor is radiated at, for sensing the 4th IR wavelengths, the 4th produce on target detection object
Signal.
For realizing above-mentioned purpose of the present invention, present invention also offers a kind of micro-signal accurate measurement side of biosensor
Method, is applied in micro-signal precision measurement apparatus, and this micro-signal precision measurement apparatus is connected with the first biosensor, the second life
Thing sensor, the 3rd biosensor and the 4th biosensor, described micro-signal precision measurement apparatus include the first difference
Amplifier, the second difference amplifier, the 3rd difference amplifier, adc amplification chip and single-chip microcomputer, the first difference amplifier and
Two difference amplifiers all include two first resistors and two second resistances, and the 3rd difference amplifier includes two 3rd resistors
And two the 4th resistance, described adc amplification chip includes amplifying circuit chip and adc circuit chip, wherein, described biological passes
The micro-signal precision measurement method of sensor comprises the steps:
Described first difference transport and placing device obtains from first biosensor acquisition the first micro-signal and from the second biosensor
Take the second micro-signal；
First micro-signal and the second micro-signal are passed through the amplification of this first difference transport and placing device by described first difference transport and placing device
Multiple carries out calculus of differences and amplifies and obtain the first differential signal, and it is poor that the amplification of described first difference amplifier is equal to first
The ratio of the resistance value of the second resistance in point amplifier and first resistor；
Described second difference amplifier obtains from the 3rd biosensor acquisition the 3rd micro-signal and from the 4th biosensor
Take the 4th micro-signal；
3rd micro-signal and the 4th micro-signal are passed through the amplification of this second difference amplifier by described second difference amplifier
Multiple carries out calculus of differences and amplifies and obtain the second differential signal, and it is poor that the amplification of described second difference amplifier is equal to first
Divide the amplification of amplifier；
First differential signal and the second differential signal are passed through the 3rd difference amplifier by described 3rd difference amplifier
Amplification carries out calculus of differences amplifying and obtains measuring characteristic signal, and the amplification of described 3rd difference amplifier is equal to the
The ratio of the resistance value of the 4th resistance of three difference amplifiers and 3rd resistor；
Described measurement characteristic signal is carried out letter by the amplification of this amplifying circuit chip by described amplifying circuit chip
Number amplify after export to adc circuit chip, the amplification of described amplifying circuit chip is the intrinsic spy of this amplifying circuit chip
Definite value；
Measurement characteristic signal after amplifying is carried out digital-to-analogue conversion and exports to enter to described single-chip microcomputer by described adc circuit chip
Row signal measurement is analyzed；
Wherein, the temperature coefficient of the first difference amplifier is equal to the temperature coefficient of second resistance and the temperature system of first resistor
The ratio of number, the temperature coefficient of the second difference amplifier is equal with the temperature coefficient of the first difference amplifier, the 3rd differential amplification
The temperature coefficient of device is equal to the ratio of the temperature coefficient of the 4th resistance and the temperature coefficient of 3rd resistor, the first difference amplifier
The product of temperature coefficient of temperature coefficient and the 3rd difference amplifier is equal in magnitude with the temperature coefficient of amplifying circuit chip and accords with
Number contrary.
Further, described first micro-signal is that the first biosensor senses first wave length Infrared irradiation in target
The feature signal of telecommunication producing in detection object, the second micro-signal is that the second biosensor senses second wave length Infrared irradiation
The feature signal of telecommunication producing on target detection object, it is infrared that the 3rd micro-signal is that the 3rd biosensor senses the 3rd wavelength
The feature signal of telecommunication that light irradiation produces on target detection object, the 4th micro-signal is that the 4th biosensor senses the 4th ripple
The feature signal of telecommunication that long Infrared irradiation produces on target detection object.
Compared to prior art, the micro-signal precision measurement apparatus of biosensor of the present invention and method are using above-mentioned
Technical scheme, achieves following technique effect: by obtaining the faint feature signal of telecommunication in four roads and being amplified by multi-level differential
Device carry out calculus of differences and carry out high magnification numbe amplify obtain measure characteristic signal such that it is able to measure faint feature telecommunications
Number；Balance out amplifying circuit chip itself using the impact that the temperature drift that multiple differential amplifier produces is disturbed to small-signal
The impact that the temperature drift producing is disturbed to small-signal carries out letter such that it is able to eliminate small-signal in high magnification numbe amplifying circuit
The signal interference that when number amplifying, the temperature drift that run into produces, improves the accuracy of measurement small-signal.
Brief description
Fig. 1 is the electrical block diagram of the micro-signal precision measurement apparatus preferred embodiment of biosensor of the present invention；
Fig. 2 is the method flow diagram of the micro-signal precision measurement method preferred embodiment of biosensor of the present invention.
The realization of the object of the invention, functional characteristics and advantage will be described further in conjunction with the embodiments referring to the drawings.
Specific embodiment
For further illustrating that the present invention is to reach technological means and effect that above-mentioned purpose is taken, below in conjunction with accompanying drawing
And preferred embodiment, the specific embodiment of the present invention, structure, feature and its effect are described in detail.It should be appreciated that this
The described specific embodiment in place, only in order to explain the present invention, is not intended to limit the present invention.
As shown in figure 1, Fig. 1 is the circuit knot of the micro-signal precision measurement apparatus preferred embodiment of biosensor of the present invention
Structure schematic diagram.In the present embodiment, described micro-signal precision measurement apparatus 1 include but not limited to, the first difference amplifier
11st, the second difference amplifier 12, the 3rd difference amplifier 13, adc (digital-to-analogue conversion) amplification chip 14 and single-chip microcomputer 15.First
The first input end of difference amplifier 11 connects to the first biosensor 2, and the second input of the first difference amplifier 11 is even
It is connected to the second biosensor 3, the first input end of the second difference amplifier 12 connects to the 3rd biosensor 4, and second is poor
The second input dividing amplifier 12 connects to the 4th biosensor 5.The outfan of described first difference amplifier 11 connects
To the first input end of the 3rd difference amplifier 13, the outfan of the second difference amplifier 12 connects to the 3rd difference amplifier 13
The second input, the outfan of the 3rd difference amplifier 13 connects to the input of described adc amplification chip 14, described adc
The outfan of amplification chip 14 connects to described single-chip microcomputer 15.
Described first biosensor 2 is used for from target detection object acquisition first micro-signal, and the second biosensor 3 is used
In from target detection object acquisition second micro-signal, the 3rd biosensor 4 is used for from target detection object acquisition the 3rd wechat
Number, the 4th biosensor 5 is used for from target detection object acquisition the 4th micro-signal.In the present embodiment, by using respectively
To on target detection object, therefore, the first micro-signal is that the first biosensor 2 senses to the Infrared irradiation of four kinds of different wave lengths
The feature signal of telecommunication producing on target detection object to first wave length Infrared irradiation, the second micro-signal is the second bio-sensing
Device 3 senses the feature signal of telecommunication that second wave length Infrared irradiation produces on target detection object, and the 3rd micro-signal is the 3rd
Biosensor 4 senses the 3rd IR wavelengths and is radiated at the feature signal of telecommunication produce on target detection object, the 4th wechat
Number it is that the 4th biosensor 5 senses the 4th IR wavelengths and is radiated at the feature signal of telecommunication produce on target detection object.
The present embodiment passes through to obtain four kinds of micro-signals on target detection object for the Infrared irradiation of four kinds of different wave lengths, and to four kinds
Micro-signal carries out multi-level differential computing and amplifies the measurement characteristic signal that can measure target detection object.For example, it is desired to survey
Amount human blood glucose concentration when, respectively using four kinds of different wave lengths Infrared irradiation to blood sugar for human body measuring point (target detection
Position), you can obtain four kinds of faint blood sugar concentration signals of telecommunication respectively by four biosensors, then pass through described micro-signal
Precision measurement apparatus 1 carry out multi-level differential computing and amplify and can get human blood glucose concentration signal, and export to enter to single-chip microcomputer 5
The follow-up blood sugar concentration analysis of row.
In the present embodiment, the first difference amplifier 11 and the second difference amplifier 12 all include two first resistors r1,
Two second resistances r2 and a first crystal audion q1.One of first resistor r1 string of the first difference amplifier 11
It is coupled to the first input end of first crystal audion q1, other in which first resistor r1 of the first difference amplifier 11 is connected serially to
Second input of first crystal audion q1；One end of one of second resistance r2 of the first difference amplifier 11 connect to
The other end of the first input end of first crystal audion q1 and this second resistance r2 connects defeated to first crystal audion q1
Go out end, one end of other in which second resistance r2 of the first difference amplifier 11 connects to the second of first crystal audion q1
The other end of input and this second resistance r2 connects to earth lead.One of first resistor r1 of the second difference amplifier 12
It is connected serially to the first input end of first crystal audion q1, the other in which first resistor r1 series connection of the second difference amplifier 12
The second input to first crystal audion q1；One end of one of second resistance r2 of the second difference amplifier 12 connects
To the first input end of first crystal audion q1 and the other end of this second resistance r2 connects to first crystal audion q1's
Outfan, one end of other in which second resistance r2 of the second difference amplifier 12 connects to the of first crystal audion q1
The other end of two inputs and this second resistance r2 connects to earth lead.
First difference transport and placing device 11 is used for obtaining the first micro-signal and from the second biosensor from the first biosensor 2
3 acquisition the second micro-signals, and the amplification the first micro-signal and the second micro-signal being passed through this first difference transport and placing device 11
Carry out calculus of differences and amplify and obtain the first differential signal.Described second difference amplifier 12 is used for from the 3rd biosensor 4
Obtain the 3rd micro-signal and obtain the 4th micro-signal from the 4th biosensor 5, and by the 3rd micro-signal and the 4th micro-signal
Calculus of differences is carried out by the amplification of this second difference amplifier 12 and amplifies and obtain the second differential signal.First difference is put
The amplification of big device 11 is equal to the ratio of the resistance value of second resistance r2 in the first difference amplifier 11 and first resistor r1,
The amplification of the second difference amplifier 12 is equal with the amplification of the first difference amplifier 11.
In the present embodiment, the temperature coefficient k1 of the first difference amplifier 11 is by the second electricity in the first difference amplifier 11
The temperature coefficient of resistance r2 and first resistor r1 determines.It is appreciated that the temperature coefficient of some resistance described refers to change when temperature
The relative changing value of the resistance value of this resistance when becoming 1 DEG C, unit is ppm/ DEG C.For example, the temperature coefficient of first resistor r1 represents
For qcr1=δ r1/r1 δ t, the temperature coefficient of second resistance r2 is expressed as qcr2=δ r2/r2 δ t, and wherein, qcr1 is
The temperature coefficient of first resistor r1, qcr2 is the temperature coefficient of second resistance r2, and δ t is temperature change value, and δ r1 refers in temperature
The increased resistance value of lower first resistor r1 of degree change, δ r2 refers to the increased resistance value of second resistance r2 under temperature change ,/generation
Table division arithmetic, represents multiplying.In practical application, temperature coefficient generally adopts average temperature coefficient, and has subzero temperature
Degree coefficient, positive temperature coefficient and the critical temperature coefficient that resistance only can be undergone mutation under a certain specified temp.Described first is poor
The temperature coefficient k1 dividing amplifier 11 is equal to the temperature coefficient qcr2 of the second resistance r2 and temperature coefficient qcr1 of first resistor r1
Ratio it may be assumed that k1=qcr2/qcr1.The temperature coefficient of described second difference amplifier 12 and the temperature of the first difference amplifier 11
Degree coefficient is equal.
In the present embodiment, the 3rd difference amplifier 13 includes two 3rd resistors r3, two the 4th resistance r4 and
Individual second crystal triode q2.One of 3rd resistor r3 of the 3rd difference amplifier 13 is connected serially to the second crystal triode q2
First input end, other in which 3rd resistor r3 is connected serially to second input of the second crystal triode q2；3rd difference
One end of one of them the 4th resistance r4 of amplifier 13 connects to the first input end and the 4th of the second crystal triode q2
The other end of resistance r4 connects to the outfan of the second crystal triode q2, one end of other in which the 4th resistance r4 connect to
The other end of second input of the second crystal triode q2 and the 4th resistance r4 connects to earth lead.
Described 3rd difference amplifier 13 is used for putting the first differential signal and the second differential signal by the 3rd difference
The amplification of big device 13 carries out calculus of differences and amplifies and obtain measuring characteristic signal.In the present embodiment, described 3rd difference
The ratio equal to the 4th resistance r4 in the 3rd difference amplifier 13 and the resistance value of 3rd resistor r3 for the amplification of amplifier 13
Value.The temperature coefficient k2 of described 3rd difference amplifier 13 is by the 4th resistance r4 in the 3rd difference amplifier 13 and 3rd resistor
The temperature coefficient of r3 determines.For example, the temperature coefficient of 3rd resistor r3 is expressed as qcr3=δ r3/r3 δ t, the 4th resistance r4
Temperature coefficient be expressed as qcr4=δ r4/r4 δ t, wherein, qcr3 be 3rd resistor r3 temperature coefficient, qcr4 be the 4th
The temperature coefficient of resistance r4, δ t is temperature change value, and δ r3 refers to the increased resistance value of 3rd resistor r3 under temperature change,
δ r4 refers to the increased resistance value of the 4th resistance r4 under temperature change ,/represent division arithmetic, represent multiplying.Described
The temperature coefficient k2 of the 3rd difference amplifier 13 is equal to the temperature coefficient qcr4 of the 4th resistance r4 and the temperature system of 3rd resistor r3
The ratio of number qcr3 is it may be assumed that k2=qcr4/qcr3.
In the present embodiment, described adc amplification chip 14 include but not limited to, and amplifying circuit chip 141 and adc are electric
Road chip 142.The input of described amplifying circuit chip 141 connects to the outfan of the 3rd difference amplifier 13, described amplification
The outfan of circuit chip 141 connects to the input of adc circuit chip 142, and the outfan of described adc circuit chip 142 is even
It is connected to described single-chip microcomputer 15.Described amplifying circuit chip 141 is used for for described measurement characteristic signal passing through this amplifying circuit chip
141 amplification exports after carrying out signal amplification to adc circuit chip 142, after this adc circuit chip 142 is used for amplifying
Measurement characteristic signal carry out digital-to-analogue conversion and export to single-chip microcomputer 15, to carry out follow-up signal measurement analysis.
In the present embodiment, described amplifying circuit chip 141 is amplifying circuit composition of the prior art, described adc electricity
Road chip 142 is D/A converting circuit composition of the prior art.It will be appreciated by persons skilled in the art that described amplification
The amplification of circuit chip 141 is the intrinsic particular value of this amplifying circuit chip 141, and that is, this amplifying circuit chip 141 is intrinsic
Amplification attribute, but operationally can by this amplifying circuit chip 141 temperature coefficient k3 produce temperature drift be affected.Institute
The temperature coefficient k3 stating amplifying circuit chip 141 is the intrinsic temperature characterisitic of this amplifying circuit chip 141, and it reflects this amplification electricity
Road chip 141 causes the order of severity of amplifying circuit chip 141 occurrence temperature drift in the case of temperature change.Described
Amplifying circuit chip 141 can produce temperature drift phenomenon with temperature change and produce signal interference to measurement characteristic signal,
Thus leading to measurement characteristic signal to be submerged among interference signal, therefore cannot accurately measure measurement characteristic signal.?
In the present embodiment, by determining first resistor r1 and second resistance in the first difference amplifier 11 and the second difference amplifier 12
The temperature coefficient of r2, and by determining the temperature system of 3rd resistor r3 in the 3rd difference amplifier 13 and the 4th resistance r4
Number so that the temperature coefficient k1 of the first difference amplifier 11 and the product of temperature coefficient k2 of the 3rd difference amplifier 13 with described
The temperature coefficient k3 of amplifying circuit chip 141 is equal in magnitude and symbol is contrary, hence in so that the first difference amplifier 11 and the 3rd
The temperature drift that the impact that the temperature drift that difference amplifier 13 produces is disturbed to signal is produced with amplifying circuit chip 141 is to letter
Number interference impact cancel out each other such that it is able to eliminates small-signal high magnification numbe amplifying circuit carry out signal amplification when run into
Temperature drift produce signal interference, improve measurement small-signal accuracy.
For realizing the object of the invention, present invention also offers a kind of micro-signal precision measurement method of biosensor, should
For in micro-signal precision measurement apparatus 1 as shown in Figure 1.As shown in Fig. 2 Fig. 2 is the micro-signal of biosensor of the present invention
The method flow diagram of precision measurement method preferred embodiment.In the present embodiment, described method for temperature drift compensation includes walking
Rapid s21 is to step s27.
Step s21, the first difference amplifier obtains the first micro-signal and from the second bio-sensing from the first biosensor
Device obtains the second micro-signal；Specifically, the first difference transport and placing device 11 obtains the first micro-signal and from the from the first biosensor 2
Two biosensor 3 obtains the second micro-signal.In the present embodiment, described first micro-signal is to be felt by the first biosensor 2
Survey the feature signal of telecommunication that first wave length Infrared irradiation produces on target detection object, the second micro-signal is by the second biological biography
Sensor 3 senses the feature signal of telecommunication that second wave length Infrared irradiation produces on target detection object.
Step s22, the first micro-signal and the second micro-signal are passed through the first difference transport and placing device 11 by the first difference amplifier
Amplification carries out calculus of differences and amplifies and obtain the first differential signal；Specifically, the first difference transport and placing device 11 is by the first wechat
Number and the second micro-signal calculus of differences is carried out by the amplification of this first difference transport and placing device 11 and amplifies and obtain the first difference
Signal.The amplification of described first difference transport and placing device 11 is equal to second resistance r2 and the first electricity in the first difference amplifier 11
The ratio of the resistance value of resistance r1, and affected by the temperature coefficient k1 generation temperature drift of the first difference transport and placing device 11.At this
In embodiment, the temperature coefficient k1 of the first difference amplifier 11 is by second resistance r2 in the first difference amplifier 11 and the first electricity
The temperature coefficient of resistance r1 determines.For example, the temperature coefficient of first resistor r1 is expressed as qcr1=δ r1/r1 δ t, second resistance
The temperature coefficient of r2 is expressed as qcr2=δ r2/r2 δ t, and wherein, qcr1 is the temperature coefficient of first resistor r1, and qcr2 is the
The temperature coefficient of two resistance r2, δ t is temperature change value, and δ r1 refers to the resistance variations of first resistor r1 under temperature change
Value, δ r2 refers to the increased resistance value of second resistance r2 under temperature change ,/represent division arithmetic, represent multiplying.?
During practical application, temperature coefficient generally adopts average temperature coefficient, and has negative temperature coefficient, positive temperature coefficient and a certain specific
At a temperature of the critical temperature coefficient that only can undergo mutation of resistance.The temperature coefficient k1 of described first difference amplifier 11 is equal to second
The ratio of the temperature coefficient qcr2 of resistance r2 and the qcr1 of temperature coefficient of first resistor r1 is it may be assumed that k1=qcr2/qcr1.
Step s23, the second difference amplifier obtains the 3rd micro-signal and from the 4th bio-sensing from the 3rd biosensor
Device obtains the 4th micro-signal；Specifically, the second difference amplifier 12 obtains the 3rd micro-signal and from the from the 3rd biosensor 4
Four biosensor 5 obtains the 4th micro-signal.In the present embodiment, described 3rd micro-signal is to be felt by the 3rd biosensor 4
Survey the 3rd IR wavelengths and the feature signal of telecommunication produce is radiated on target detection object, the 4th micro-signal is by the 4th biological biography
Sensor 5 senses the 4th IR wavelengths and is radiated at the feature signal of telecommunication produce on target detection object.
Step s24, the 3rd micro-signal and the 4th micro-signal are passed through this second difference amplifier by the second difference amplifier
Amplification carries out calculus of differences and amplifies and obtain the second differential signal；Specifically, the second difference amplifier 12 is by the 3rd wechat
Number and the 4th micro-signal calculus of differences is carried out by the amplification of this second difference amplifier 12 and amplifies and obtain the second difference
Signal.In the present embodiment, the amplification of the amplification of described second difference amplifier 12 and the first difference amplifier 11
Equal.
Step s25, the first differential signal and the second differential signal are passed through the 3rd differential amplification by the 3rd difference amplifier
Second amplification of device carries out calculus of differences amplifying and obtains measuring characteristic signal；Specifically, the 3rd difference amplifier 13 will
First differential signal and the second differential signal are carried out calculus of differences and are amplified by the amplification of the 3rd difference amplifier 13
Obtain measuring characteristic signal.The amplification of described 3rd difference amplifier 13 is equal to the 4th electricity in the 3rd difference amplifier 13
The ratio of the resistance value of resistance r4 and 3rd resistor r3, and it is subject to the temperature coefficient k2 of the 3rd difference amplifier 13 to produce temperature drift
Impact.In the present embodiment, the temperature coefficient k2 of described 3rd difference amplifier 13 is by the 3rd difference amplifier 13
The temperature coefficient of four resistance r4 and 3rd resistor r3 determines.For example, the temperature coefficient of 3rd resistor r3 is expressed as qcr3=δ r3/
The temperature coefficient of r3 δ t, the 4th resistance r4 is expressed as qcr4=δ r4/r4 δ t, and wherein, qcr3 is 3rd resistor r3
Temperature coefficient, qcr4 is the temperature coefficient of the 4th resistance r4, and δ t is temperature change value, and δ r3 refers to the 3rd under temperature change
The increased resistance value of resistance r3, δ r4 refers to the increased resistance value of the 4th resistance r4 under temperature change ,/represent division fortune
Calculate, represent multiplying.The temperature coefficient k2 of described 3rd difference amplifier 13 is equal to the temperature coefficient of the 4th resistance r4
The ratio of the temperature coefficient qcr3 of qcr4 and 3rd resistor r3 is it may be assumed that k2=qcr4/qcr3.
Step s26, amplifying circuit chip carries out letter by measuring characteristic signal by the amplification of this amplifying circuit chip
Number amplify after export to adc circuit chip；Specifically, described measurement characteristic signal is passed through this amplification by amplifying circuit chip 141
The amplification of circuit chip 141 exports to adc circuit chip 142 after carrying out signal amplification.In the present embodiment, described amplification
Circuit chip 141 is amplifying circuit composition of the prior art, and described adc circuit chip 142 turns for digital-to-analogue of the prior art
Change circuit composition.It will be appreciated by persons skilled in the art that the amplification of described amplifying circuit chip 141 is this amplification electricity
The intrinsic particular value of road chip 141, that is, this amplifying circuit chip 141 inherently amplify attribute, but operationally can be amplified by this
The temperature coefficient k3 of circuit chip 141 produces the impact of temperature drift.The temperature coefficient k3 of described amplifying circuit chip 141 is should
The intrinsic temperature characterisitic of amplifying circuit chip 141, it reflects that this amplifying circuit chip 141 is made in the case of temperature change
Become the order of severity of amplifying circuit chip 141 occurrence temperature drift.Described amplifying circuit chip 141 is with temperature change meeting
Produce temperature drift phenomenon and signal interference is produced to measurement characteristic signal, thus leading to measurement characteristic signal to be submerged in interference letter
Among number, therefore cannot accurately measure measurement characteristic signal.In the present embodiment, by determining the first difference amplifier 11
With the temperature coefficient of first resistor r1 in the second difference amplifier 12 and second resistance r2, and by determine the 3rd difference put
The temperature coefficient of 3rd resistor r3 in big device 13 and the 4th resistance r4 so that the temperature coefficient k1 of the first difference amplifier 11 and
The temperature coefficient k3 of the product of temperature coefficient k2 of the 3rd difference amplifier 13 and described amplifying circuit chip 141 equal in magnitude and
Symbol is contrary, hence in so that the temperature drift that the first difference amplifier 11 and the 3rd difference amplifier 13 produce is done to small-signal
The impact that the temperature drift that the impact disturbed and amplifying circuit chip 141 produce is disturbed to small-signal cancel out each other such that it is able to
Eliminate small-signal and carry out, in high magnification numbe amplifying circuit, the signal interference that when signal amplifies, temperature drift produces.
Step s27, the measurement characteristic signal after amplifying is carried out exporting to enter to single-chip microcomputer after digital-to-analogue conversion by adc circuit chip
Row signal measurement is analyzed；Specifically, the measurement characteristic signal after amplifying is carried out digital-to-analogue conversion and exports by adc circuit chip 142
To single-chip microcomputer 15, to carry out follow-up signal measurement analysis.
The micro-signal precision measurement apparatus of biosensor of the present invention and method, the feature faint by obtaining four roads
The signal of telecommunication and by multiple differential amplifier carry out calculus of differences and carry out high magnification numbe amplify obtain measure characteristic signal, so as to
Enough measure the faint feature signal of telecommunication；Impact small-signal disturbed using the temperature drift that multiple differential amplifier produces
Balance out the temperature drift impact that small-signal disturb of amplifying circuit chip generation itself such that it is able to elimination small-signal
The signal interference that the temperature drift carrying out being run into when signal amplifies in high magnification numbe amplifying circuit produces, improves measurement small-signal
Accuracy.
These are only the preferred embodiments of the present invention, not thereby limit the present invention the scope of the claims, every using this
Equivalent structure or equivalent function conversion that bright description and accompanying drawing content are made, or directly or indirectly it is used in other related skills
Art field, is included within the scope of the present invention.
Claims (8)
1. the micro-signal precision measurement apparatus of a kind of biosensor, this micro-signal precision measurement apparatus is connected with the first biological biography
Sensor, the second biosensor, the 3rd biosensor and the 4th biosensor are it is characterised in that described micro-signal is smart
Close measurement apparatus include the first difference amplifier, the second difference amplifier, the 3rd difference amplifier, adc amplification chip and list
Piece machine, described first difference amplifier and the second difference amplifier all include two first resistors and two second resistances, institute
State the 3rd difference amplifier and include two 3rd resistors and two the 4th resistance, wherein:
Described first difference transport and placing device is used for from first biosensor acquisition the first micro-signal and obtains from the second biosensor
Take the second micro-signal, the first micro-signal and the second micro-signal are carried out difference fortune by the amplification of this first difference transport and placing device
Calculate and amplify and obtain the first differential signal, the amplification of described first difference amplifier is equal in the first difference amplifier the
The ratio of the resistance value of two resistance and first resistor；
Described second difference amplifier is used for from the 3rd biosensor acquisition the 3rd micro-signal and obtains from the 4th biosensor
Take the 4th micro-signal, the 3rd micro-signal and the 4th micro-signal are carried out difference fortune by the amplification of this second difference amplifier
Calculate and amplify and obtain the second differential signal, the amplification of described second difference amplifier is equal to the amplification of the first difference amplifier
Multiple；
Described 3rd difference amplifier is used for for the first differential signal and the second differential signal passing through the 3rd difference amplifier
Amplification carries out calculus of differences amplifying and obtains measuring characteristic signal, and the amplification of described 3rd difference amplifier is equal to the
The ratio of the resistance value of the 4th resistance in three difference amplifiers and 3rd resistor；
Described adc amplification chip includes amplifying circuit chip and adc circuit chip, and described amplifying circuit chip is used for will be described
Measurement characteristic signal exports to adc circuit chip after the amplification of this amplifying circuit chip carries out signal amplification, described
The amplification of amplifying circuit chip is the intrinsic particular value of this amplifying circuit chip；
Wherein, the temperature coefficient of the first difference amplifier is equal to the temperature coefficient of second resistance and the temperature coefficient of first resistor
Ratio, the temperature coefficient of the second difference amplifier is equal with the temperature coefficient of the first difference amplifier, the 3rd difference amplifier
Temperature coefficient is equal to the ratio of the temperature coefficient of the 4th resistance and the temperature coefficient of 3rd resistor, the temperature of the first difference amplifier
The product of temperature coefficient of coefficient and the 3rd difference amplifier is equal in magnitude with the temperature coefficient of amplifying circuit chip and symbol phase
Instead.
2. biosensor as claimed in claim 1 micro-signal precision measurement apparatus it is characterised in that:
The first input end of described first difference amplifier connects to the first biosensor, and the second of the first difference amplifier is defeated
Enter end to connect to the second biosensor；
The first input end of described second difference amplifier connects to the 3rd biosensor, and the second of the second difference amplifier is defeated
Enter end to connect to the 4th biosensor；
The outfan of described first difference amplifier connects to the first input end of the 3rd difference amplifier, the second difference amplifier
Outfan connect to the second input of the 3rd difference amplifier；
The outfan of described 3rd difference amplifier connects to the input of described amplifying circuit chip, described amplifying circuit chip
Outfan connect to the input of adc circuit chip, the outfan of described adc circuit chip connects to described single-chip microcomputer.
3. the micro-signal precision measurement apparatus of biosensor as claimed in claim 1 are it is characterised in that described first difference
Amplifier also includes first crystal audion, and one of first resistor of the first difference amplifier is connected serially to first crystal three pole
The first input end of pipe, it is second defeated that the other in which first resistor of the first difference amplifier is connected serially to first crystal audion
Enter end, one end of one of second resistance of the first difference amplifier connect to first crystal audion first input end and
The other end of this second resistance connects to the outfan of first crystal audion, the other in which second of the first difference amplifier
One end of resistance connects to the second input of first crystal audion and the other end of this second resistance connects to earth lead.
4. the micro-signal precision measurement apparatus of biosensor as claimed in claim 1 are it is characterised in that described second difference
Amplifier also includes first crystal audion, and one of first resistor of the second difference amplifier is connected serially to first crystal three pole
The first input end of pipe, it is second defeated that the other in which first resistor of the second difference amplifier is connected serially to first crystal audion
Enter end, one end of one of second resistance of the second difference amplifier connect to first crystal audion first input end and
The other end of second resistance connects to the outfan of first crystal audion, other in which second electricity of the second difference amplifier
One end of resistance connects to the second input of first crystal audion and the other end of second resistance connects to earth lead.
5. the micro-signal precision measurement apparatus of biosensor as claimed in claim 1 are it is characterised in that described 3rd difference
Amplifier also includes the second crystal triode, and one of 3rd resistor is connected serially to the first input end of the second crystal triode,
Other in which 3rd resistor is connected serially to the second input of the second crystal triode, and one end of one of them the 4th resistance connects
To the first input end of the second crystal triode and the other end of the 4th resistance connects to the outfan of the second crystal triode,
One end of other in which the 4th resistance connects the other end of the second input to the second crystal triode and the 4th resistance
Connect to earth lead.
6. the micro-signal precision measurement apparatus of the biosensor as described in any one of claim 1 to 5 are it is characterised in that institute
State the first biosensor for sensing the first micro-signal that first wave length Infrared irradiation produces on target detection object, the
Two biosensors are used for sensing the second micro-signal that second wave length Infrared irradiation produces on target detection object, the three lives
Thing sensor is used for sensing the 3rd IR wavelengths and is radiated at the 3rd micro-signal produce on target detection object, the 4th biological biography
Sensor is used for sensing the 4th IR wavelengths and is radiated at the 4th micro-signal produce on target detection object.
7. the micro-signal precision measurement method of a kind of biosensor, is applied in micro-signal precision measurement apparatus, this micro-signal
Precision measurement apparatus are connected with the biological biography of the first biosensor, the second biosensor, the 3rd biosensor and the 4th
Sensor it is characterised in that described micro-signal precision measurement apparatus include the first difference amplifier, the second difference amplifier, the 3rd
Difference amplifier, adc amplification chip and single-chip microcomputer, the first difference amplifier and the second difference amplifier all include two first
Resistance and two second resistances, the 3rd difference amplifier includes two 3rd resistors and two the 4th resistance, and described adc is put
Large chip includes amplifying circuit chip and adc circuit chip, wherein, the micro-signal precision measurement method bag of described biosensor
Include following steps:
Described first difference transport and placing device obtains the first micro-signal from the first biosensor and obtains the from the second biosensor
Two micro-signals；
First micro-signal and the second micro-signal are passed through the amplification of this first difference transport and placing device by described first difference transport and placing device
Carry out calculus of differences and amplify and obtain the first differential signal, the amplification of described first difference amplifier is put equal to the first difference
The ratio of the resistance value of the second resistance in big device and first resistor；
Described second difference amplifier obtains the 3rd micro-signal from the 3rd biosensor and obtains the from the 4th biosensor
Four micro-signals；
3rd micro-signal and the 4th micro-signal are passed through the amplification of this second difference amplifier by described second difference amplifier
Carry out calculus of differences and amplify and obtain the second differential signal, the amplification of described second difference amplifier is put equal to the first difference
The amplification of big device；
First differential signal and the second differential signal are passed through the amplification of the 3rd difference amplifier by described 3rd difference amplifier
Multiple carries out calculus of differences amplifying and obtains measuring characteristic signal, and it is poor that the amplification of described 3rd difference amplifier is equal to the 3rd
Divide the 4th resistance of amplifier and the ratio of the resistance value of 3rd resistor；
Described measurement characteristic signal is carried out signal by the amplification of this amplifying circuit chip and puts by described amplifying circuit chip
Export afterwards greatly to adc circuit chip, the amplification of described amplifying circuit chip is the intrinsic particular value of this amplifying circuit chip；
Measurement characteristic signal after amplifying is carried out digital-to-analogue conversion and exports and carry out letter to described single-chip microcomputer by described adc circuit chip
Number measurement analysis；
Wherein, the temperature coefficient of the first difference amplifier is equal to the temperature coefficient of second resistance and the temperature coefficient of first resistor
Ratio, the temperature coefficient of the second difference amplifier is equal with the temperature coefficient of the first difference amplifier, the 3rd difference amplifier
Temperature coefficient is equal to the ratio of the temperature coefficient of the 4th resistance and the temperature coefficient of 3rd resistor, the temperature of the first difference amplifier
The product of temperature coefficient of coefficient and the 3rd difference amplifier is equal in magnitude with the temperature coefficient of amplifying circuit chip and symbol phase
Instead.
8. biosensor as claimed in claim 7 micro-signal precision measurement method it is characterised in that it is characterized in that,
Described first micro-signal is that the first biosensor senses first wave length Infrared irradiation and produces on target detection object
The feature signal of telecommunication, the second micro-signal is that the second biosensor senses second wave length Infrared irradiation on target detection object
The feature signal of telecommunication producing, the 3rd micro-signal is that the 3rd biosensor senses the 3rd IR wavelengths and is radiated at target detection
The feature signal of telecommunication producing on object, the 4th micro-signal is that the 4th biosensor senses the 4th IR wavelengths and is radiated at mesh
The feature signal of telecommunication producing in mark detection object.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610741562.0A CN106344039A (en) | 2016-08-26 | 2016-08-26 | Weak signal precision measurement device and method of bio-sensors |
| PCT/CN2017/084228 WO2018036210A1 (en) | 2016-08-26 | 2017-05-12 | Apparatus and method for precision measurement of micro signals from biosensors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610741562.0A CN106344039A (en) | 2016-08-26 | 2016-08-26 | Weak signal precision measurement device and method of bio-sensors |
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| CN201610741562.0A Withdrawn CN106344039A (en) | 2016-08-26 | 2016-08-26 | Weak signal precision measurement device and method of bio-sensors |
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| WO (1) | WO2018036210A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018036212A1 (en) * | 2016-08-26 | 2018-03-01 | 深圳市前海安测信息技术有限公司 | Precision measurement circuit for micro signals |
| WO2018036209A1 (en) * | 2016-08-26 | 2018-03-01 | 深圳市前海安测信息技术有限公司 | Apparatus and method for multistage amplification of micro signals from biosensors |
| WO2018036211A1 (en) * | 2016-08-26 | 2018-03-01 | 深圳市前海安测信息技术有限公司 | Temperature drift compensation apparatus and method for measuring micro signals |
| WO2018036210A1 (en) * | 2016-08-26 | 2018-03-01 | 深圳市前海安测信息技术有限公司 | Apparatus and method for precision measurement of micro signals from biosensors |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108593180A (en) * | 2018-04-26 | 2018-09-28 | 国网江西省电力有限公司南昌供电分公司 | A kind of tension transmitter for pole wire tensile measurer |
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| US7021821B2 (en) * | 2004-05-28 | 2006-04-04 | Honeywell International Inc. | Differential thermal sensors |
| US20060091294A1 (en) * | 2004-10-29 | 2006-05-04 | Michael Frank | Apparatus and method for interference suppression in optical or radiation sensors |
| CN103026252B (en) * | 2010-07-23 | 2016-01-06 | 皇家飞利浦电子股份有限公司 | For removing the dual pressure sensor signal chains that mutual coupling MRI disturbs |
| CN205139762U (en) * | 2015-12-04 | 2016-04-06 | 潍坊医学院 | Linear difference hall voltage generator of tiling structure |
| CN206151465U (en) * | 2016-08-26 | 2017-05-10 | 深圳市前海安测信息技术有限公司 | Little signal precision measurement circuit |
| CN106344039A (en) * | 2016-08-26 | 2017-01-25 | 深圳市前海安测信息技术有限公司 | Weak signal precision measurement device and method of bio-sensors |
| CN106374861A (en) * | 2016-08-26 | 2017-02-01 | 深圳市前海安测信息技术有限公司 | Micro signal multistage amplification apparatus and method of biosensors |
| CN106343974A (en) * | 2016-08-26 | 2017-01-25 | 深圳市前海安测信息技术有限公司 | Temperature drift compensation device and method for measuring micro signal |
-
2016
- 2016-08-26 CN CN201610741562.0A patent/CN106344039A/en not_active Withdrawn
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018036212A1 (en) * | 2016-08-26 | 2018-03-01 | 深圳市前海安测信息技术有限公司 | Precision measurement circuit for micro signals |
| WO2018036209A1 (en) * | 2016-08-26 | 2018-03-01 | 深圳市前海安测信息技术有限公司 | Apparatus and method for multistage amplification of micro signals from biosensors |
| WO2018036211A1 (en) * | 2016-08-26 | 2018-03-01 | 深圳市前海安测信息技术有限公司 | Temperature drift compensation apparatus and method for measuring micro signals |
| WO2018036210A1 (en) * | 2016-08-26 | 2018-03-01 | 深圳市前海安测信息技术有限公司 | Apparatus and method for precision measurement of micro signals from biosensors |
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| WO2018036210A1 (en) | 2018-03-01 |
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