CN106290153B - Automatic analysing apparatus and image capture method - Google Patents
Automatic analysing apparatus and image capture method Download PDFInfo
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- CN106290153B CN106290153B CN201610430779.XA CN201610430779A CN106290153B CN 106290153 B CN106290153 B CN 106290153B CN 201610430779 A CN201610430779 A CN 201610430779A CN 106290153 B CN106290153 B CN 106290153B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
Abstract
The present invention provides a kind of automatic analysing apparatus and image capture method, just can determine the exception of dispensing not against the color or transparency of dispensing object, and can be improved the reliability of analysis.Automatic analysing apparatus includes dispenser, after being inserted into dispense probe in accommodating the container of liquid of dispensing object and attracting liquid, liquid is inserted into reaction vessel and is discharged by dispense probe, to dispense the liquid of dispensing object；Photographic device is imaged to from the front end of dispense probe to the position of reaction vessel discharge liquid；And background portion, to configure across the reaction vessel mode opposed with photographic device, and there is bright portion and the side side of at least side for being configured at bright portion of at least central portion for being configured at the region using photographic device camera shooting extending in the up and down direction and the brightness dark portion lower than bright portion.
Description
Technical field
The present invention relates to the qualitative and quantitative analysis of the organism samples such as the blood be contained in sample container or urine
Automatic analysing apparatus and its image capture method.
Background technique
In the automatic analysing apparatus for the qualitative and quantitative analysis for carrying out the organism samples such as blood or urine (hereinafter referred to as sample)
In, the sample being contained in sample container and the reagent being contained in reagent container are dispensed into reaction vessel and make its reaction
And analyzed, in order to obtain accurately analysis as a result, from each container to reaction vessel it is normal dispense be essential.
As the technology for confirming that the dispensing of this sample and reagent is normally carried out, for example, 1 (Japanese Unexamined Patent Publication of patent document
2011-237344 bulletin) a kind of sample dispenser is disclosed, include at least one of the pressure in detection dispensing runner
A pressure sensor；The pressure value storage for storing to timing the output valve of the pressure sensor when dispensing movement of sample is single
Member；And the storage unit of Memory Reference database, the benchmark database with probe is normal by attracting or when discharge sample
The output valve of the timing of above-mentioned pressure sensor is constituted, to the pressure based on timing being stored in pressure value storage unit
Sensor output value and the comparison data and benchmark database that generate carry out multi-variables analysis, sample is determined based on analysis result
Dispensing movement have it is without exception.
Existing technical literature
Patent document
Patent document 1: Japanese Unexamined Patent Publication 2011-237344 bulletin
Summary of the invention
Problems to be solved by the invention
But about sample or reagent handled in automatic analysing apparatus, colorless and transparent is also more, above-mentioned existing
Have dispensed in technology object be it is colorless and transparent in the case where the contrast of image be lower, it is difficult to accurately determine the exception of dispensing.
Present invention has been made in view of the above circumstances, the purpose is to provide a kind of automatic analysing apparatus and image capture method,
It just can determine the exception of dispensing not against the color or transparency of dispensing object, and can be improved the reliability of analysis.
The solution to the problem
To achieve the goals above, the present invention includes dispenser, passes through the container in the liquid for accommodating dispensing object
Middle insertion dispense probe and after attracting aforesaid liquid, above-mentioned dispense probe is inserted into reaction vessel and above-mentioned liquid is discharged
Body, to dispense the liquid of above-mentioned dispensing object；Photographic device is arranged from the front end of above-mentioned dispense probe to above-mentioned reaction vessel
The position of aforesaid liquid out is imaged；And background portion, with opposed with above-mentioned photographic device across above-mentioned reaction vessel
Mode configures, and has and be configured at the region for utilizing the camera shooting of above-mentioned photographic device extending in the up and down direction at least
The bright portion of central portion and a side of at least side for being configured at above-mentioned bright portion and the brightness darkness lower than above-mentioned bright portion
Portion.
The effect of invention
Just can determine the exception of dispensing not against the color or transparency of dispensing object, and can be improved analysis can
By property.
Detailed description of the invention
Fig. 1 is to extract the camera shooting processing unit for carrying out camera shooting processing of first embodiment out together with surrounding structure and indicate
Figure.
Fig. 2 is the integrally-built figure that outlined the automatic analysing apparatus of first embodiment.
Fig. 3 is the functional block diagram for indicating the detailed content of function of computer.
Fig. 4 is the figure for indicating the case where being observed from the front screen.
Fig. 5 is the top view for schematically indicating the advance route of the light in camera shooting processing unit.
Fig. 6 is the figure for indicating the relationship at screen angle and blocking rate.
Fig. 7 is the figure for indicating the sensor output and the relationship (light intensity distributions) of position that export from photographic device.
Fig. 8 is one indicated using photographic device to the image imaged the case where reagent is discharged from reagent dispense probe
The figure of example.
Fig. 9 is the comparative example as present embodiment and the figure in the discharge process of reagent that indicates.
Figure 10 is the figure for indicating an example of the measurement result of blob length of reagent.
Figure 11 is to extract the camera shooting processing unit for carrying out camera shooting processing of second embodiment and table together with surrounding structure out
The figure shown.
Figure 12 is to extract the camera shooting processing unit for carrying out camera shooting processing of third embodiment and table together with surrounding structure out
The figure shown.
Figure 13 is to extract the camera shooting processing unit for carrying out camera shooting processing of the 4th embodiment and table together with surrounding structure out
The figure shown.
Figure 14 is the figure for indicating the case where being observed from the front the screen of the 5th embodiment.
Figure 15 is the figure for schematically indicating the image of reaction vessel of sixth embodiment.
Figure 16 is the figure for schematically indicating the image of reaction vessel of the 7th embodiment.
In figure:
10- sample container, 12- sample disc, 15- sample probe, 20- the first reagent dispenser, 20a, 21a- reagent point
Infuse probe, 21- the second reagent dispenser, 22- reagent, 23- reaction solution, 24- dispensing runner, 25- constant displacement pump, 30,31- stirring
Device, 32- blibbing, 33- air entrapment, 34- attachment liquid, 35- reaction vessel, 36- reaction tray, 37- thermostat, 39- are followed
Ring water, 40- reagent container, the first reagent disc of 41-, the second reagent disc of 42-, 45- cleaning container mechanism, 47,48- transmissive window, 50-
Measurement light source, 51- spectrophotometric detector, 60- controller, 61- computer, 65- photographic device, 66- flashlight, 70- light, 75,
75A, 75C, 75D- screen (background portion), 76- become clear portion, 77,77a, 77b, 77c- darkness portion.
Specific embodiment
In the following, the embodiments of the present invention will be described with reference to the drawings.
First embodiment
First embodiment of the invention is described in detail in referring to Fig.1~Figure 10.
Fig. 2 is the integrally-built figure that outlined the automatic analysing apparatus of first embodiment, and Fig. 3 is to indicate to calculate
The functional block diagram of the detailed content of the function of machine.In addition, Fig. 1 is by the camera shooting processing unit for carrying out camera shooting processing of present embodiment
The figure extracted out and indicated together with surrounding structure.
In FIG. 1 to FIG. 3, automatic analysing apparatus is generally comprised: being accommodated as biologies such as the blood of analysis object or urine
Multiple sample containers 10 of body sample (hereinafter referred to as sample) circumferentially arrange and the sample disc 12 carried；It accommodates for trying
Multiple reagent containers 40 of the reagent of sample analysis circumferentially arrange respectively and first and second reagent disc 41,42 for carrying；Make to try
Sample is mixed with reagent and multiple reaction vessels 35 for reacting circumferentially arrange and the reaction tray 36 carried；By sample from sample
The sample container 10 of disk 12 is dispensed into the sample dispenser 15 in the reaction vessel 35 of reaction tray 36；By reagent from first and
The reagent container 40 of two reagent discs 41,42 is dispensed into first and second reagent dispenser in the reaction vessel 35 of reaction tray 36
20,21；Agitating device 30 that the mixed liquor (reaction solution) for the sample and reagent being dispensed into reaction vessel 35 is stirred,
31；The thermostat 37 configured in a manner of surrounding the movement routine of the reaction vessel 35 of reaction tray 36；Wash reaction vessels 35
Cleaning container mechanism 45；The camera shooting processing unit 80 for carrying out camera shooting processing in present embodiment；To camera shooting processing unit 80 (under including
Other camera shooting processing units stated), the movement of the first reagent dispenser 20 and the second reagent dispenser 21 controlled
Controller 60；To the measurement light source 50 of the light of reaction vessel irradiation measurement；It is anti-to irradiating and transmiting from measurement light source 50
The spectrophotometric detector 51 for answering the transmitted light of the reaction solution of container 35 to be detected；And control automatic analysing apparatus entirety is dynamic
Make, and the instruction based on the host (not shown) from operator or upper level, obtains the detection from spectrophotometric detector 51
Signal or image (following) from controller 60 and carry out various processing, and controlled with the external conduct for carrying out data transmit-receive
The computer 61 of device.In addition, in FIG. 1 to FIG. 3, for simplified illustration, to the letter between each structure of automatic analysing apparatus
Connection involved in breath transmitting, omits a part and indicates.
Sample dispenser 15 in the sample container 10 of sample for accommodating the liquid as dispensing object by being inserted into
Sample dispense probe 15a and after attracting sample, is inserted into drain sample in reaction vessel 35 for sample dispense probe 15a, from
And dispense sample.In addition, first and second reagent dispenser 20,21 passes through in the examination for accommodating the liquid as dispensing object
After being inserted into reagent dispense probe 20a, 21a in the reagent container 40 of agent and attracting reagent, reagent dispense probe 20a, 21a is inserted
Enter and reagent is discharged into reaction vessel 35, to dispense reagent.
Camera shooting processing unit 80 is configured at from the reagent dispense probe 20a of the first reagent dispenser 20 to 35 row of reaction vessel
The position of reagent out.In addition, having other camera shooting processing units of structure identical with camera shooting processing unit 80, it is configured at from the second examination
The position of reagent is discharged to reaction vessel 35 by the reagent dispense probe 21a of agent dispenser 21.In addition, in the present embodiment,
It is described in detail, closes about the camera shooting processing unit 80 on the drain position for being configured at the reagent carried out by the first reagent dispenser 20
It is omitted the description in other camera shooting processing units with structure identical with camera shooting processing unit 80.
Thermostat 37 is configured to, and recirculated water 39 riddles wherein along the movement routine of reaction vessel 35, in movement routine
The side wall in outside (the i.e., peripheral side of reaction tray 36) be configured with the transmissive window 47 that is made of the transparent component of transmitted light.
It is provided in camera shooting processing unit 80 to via being set to the constant temperature configured in a manner of the periphery for surrounding reaction tray 36
Transmissive window 47 on the side wall in the outside of slot 37 and from the front end of reagent dispense probe 20a, liquid (examination is discharged to reaction vessel 35
Agent 22) the photographic device 65 that is imaged of position；With what is configured across the mode opposed with photographic device 65 of reaction vessel 35
Screen 75 (background portion)；And from 65 side of photographic device via transmissive window 47 to the conduct light of the direction irradiation light of reaction vessel 35
The flashlight 66 in source, photographic device 65 and flashlight 66 are connect with controller 60.
Here, the screen 75 of so-called present embodiment refers to, with the side opposed with photographic device 65 across reaction vessel 35
Formula configuration, and the part (i.e. background portion) of the background as the liquid (reagent 22) imaged using photographic device 65, shape is not
Be limited to the shapes such as planar film or plate, if as the image imaged using photographic device 65 background and play a role, also
It can be formed by having indent and convex multiple components.In the present embodiment, it indicates as an example of background portion using planar
The case where screen 75, is illustrated.
In the reagent dispense probe 20a of the first reagent dispenser 20, it is connected with constant displacement pump 25 via dispensing runner 24, it is fixed
Amount pump 25 is connect with controller 60.In addition, the first reagent dispenser 20 can be hung down using driving device (not shown) in level
Histogram moves up, and is held by the reaction in the dispensing position (position of reagent 22 is discharged to reaction vessel 35) for being moved to reagent
Constant displacement pump 25 is driven in the state of insertion reagent dispense probe 20a in device 35, reagent 22 is discharged in reaction vessel 35.
Photographic device 65 is such as CCD (Charge Coupled Device) video camera or CMOS
The device of digital picture can be obtained as (Complementary Metal Oxide Semiconductor) video camera,
Optical axis is configured to vertical with transmissive window 47 and screen 75.In addition, about flashlight 66, such as fluorescent lifetime is 1 millisecond or less
, be made of LED (Light Emitting Diode) etc., and be configured to light from the oblique lateral of photographic device 65 or
Person obliquely downward is irradiated to screen 75 via transmissive window 47.
Computer 61 is included to the image real-time image processing sent from photographic device 65 via controller 60 (from image
Detect the processing for the length of liquid being discharged from dispense probe) image processing part 61a；Image based on image processing part 61a
Processing as a result, determining the determination unit the 61b whether dispensing of reagent 22 carried out by the first reagent dispenser 20 is normally implemented；
In the case where the dispensing for determining the reagent 22 carried out by the first reagent dispenser 20 with determination unit 61b is not implemented normally,
Implement the notification unit 61c to the abnormal processing of the dispensing of operator notification reagent 22；It will be used for the image of the judgement of determination unit 61b
Associated with result is determined and storage storage unit 61d；With the abnormal situation of dispensing will be being determined using determination unit 61b
Under slave reagent dispense probe 20a discharge reagent 22 image and the graphical arrangement in the case where determining normal situation in advance
And the display unit 61e for the function of showing；And the input unit 61f for implementing various settings and information input.
Fig. 4 is the figure for indicating the case where being observed from the front screen.
In Fig. 4, screen 75 includes the reaction vessel being configured in thermostat 37 in the mode opposed with photographic device 65
The movement routine side of the side wall of the inside (the i.e., central side of reaction tray 36) of 35 movement routine, and to prolong along the vertical direction
The mode stretched is configured at the bright portion 76 of at least central portion in the region imaged using photographic device 65；And it is configured at bright portion
76 left and right sides, and the dark portion 77 that brightness (or brightness) is lower than bright portion 76.In addition, as bright portion 76 and yin
The combination of dark portion 77, such as the combination high as white and black, white color system color and black system color etc., contrast.
In addition, darkness portion 77 can not be configured at the left and right sides in bright portion 76, and it is arranged in the left and right sides in bright portion 76 extremely
A few side.
Fig. 5 is the top view for schematically indicating the advance route of the light in camera shooting processing unit.
As shown in figure 5, from the surface of screen 75 by reflecting and scattering among the light generated, to reagent dispense probe
A part in light 70 that the direction of 20a is advanced is filled in the refraction at the reagent 22 that reagent dispense probe 20a is discharged to camera shooting
Set 65 advances.What is be represented by dashed line in light 70 is the light come out from bright portion 76, is filled by the immediate vicinity of reagent 22 to camera shooting
Advance in the direction for setting 65.In addition, indicated by the solid line in light 70 is the light come out from dark portion 77, by the periphery with reagent 22
Advance to the direction of photographic device 65 close part.Brightness (or brightness) is very compared with bright portion 76 in dark portion 77
It is low, if therefore from 65 side of photographic device, see that the periphery (outline portion of the reagent 22 in image) of reagent 22 becomes
Shadow (referring to following Fig. 8).
Fig. 6 is the figure for indicating the relationship at screen angle and blocking rate.
So-called screen angle α refers to, by the both ends part of the position of reagent dispense probe 20a and the width direction in bright portion 76
The line segment not connected in the horizontal direction is formed by angle α.In addition, so-called blocking rate is the examination indicated from photographic device 65
In the width direction of agent 22, the ratio of the range of the light from dark portion 77 is seen.
As shown in fig. 6, blocking rate just becomes smaller as screen angle α becomes larger since 0, if screen angle α becomes about 30 degree,
Blocking rate becomes about 0.5, if screen angle α is further enlarged, blocking rate also becomes smaller simultaneously.If screen angle α i.e., is set as 30 degree
Hereinafter, can then obtain 0.5 or more blocking rate, the half of the width direction of the image of the reagent 22 obtained by photographic device 65
Become shadow (image in dark portion 77) above, can be imaged with profile of the high contrast to reagent 22.
According to this viewpoint, in the present embodiment, the width in the bright portion 76 of screen 75 is set are as follows: than dispensing from reagent
The mobile width of the horizontal direction for the liquid (reagent 22) that the front end probe 20a is discharged to reaction vessel 35 is wide, and screen angle α becomes
30 degree or less.If in addition, also can using the photographic device of high-resolution even if blocking rate is 0.2 or so in practical application
Image procossing is enough carried out, even if screen angle α is 60 degree to 80 degree, can also obtain effect.It is thereby also possible to setting screen angle α
It is 80 degree or less.
Fig. 8 is one indicated using photographic device to the image imaged the case where reagent is discharged from reagent dispense probe
The figure of example.
The case where screen angle α is set as to 10 degree and is imaged to transparent reagent 22 is indicated in fig. 8.Thus may be used
Know, no matter reagent 22 is transparent liquid, can also be imaged with high contrast.
Here, to the bright portion 76 of screen 75 and being set for for the ratio between the brightness (or brightness) in darkness portion 77
It is bright.
In the present embodiment, the ratio between the brightness (or brightness) in bright portion 76 and darkness portion 77, according to screen
75 imaged in the case where from photographic device 65 it is corresponding with each pixel output (hereinafter referred to as sensor is defeated
It is defined the ratio between out).
Fig. 7 is the figure for indicating the sensor output and the relationship (light intensity distributions) of position that export from photographic device, horizontal axis
Indicate the position of horizontal direction, the longitudinal axis indicates sensor output (luminous intensity).
In Fig. 7, there are the case where graph representation of screen has carried out camera shooting to image shown in Fig. 8, the chart of no screen
It is the figure for indicating the case where being imaged to Fig. 9 as the comparative example with present embodiment and after indicating.Fig. 7's
In data, in the height of the approximate centre of each image, scan in the horizontal direction.Background is roughly the same in the case where no screen,
Even therefore the part of reagent, the variation of luminous intensity are also small.In the case where there is screen, in the part light of the white of central part
Intensity is high, but the part luminous intensity in the black of periphery is essentially a zero.It is changed greatly in the part luminous intensity of reagent 22,
It can be easy the position of Confirmation reagent 22.The situation indicates: in part (bright portion 76) and the week of the white of the central part of screen
The black portions (dark portion 77) in portion are enclosed, luminous intensity differs 10 times or more, and dark portion 77 is relative to bright portion 76, reflectivity 1/
10 or less.The difference of the reflectivity of central part and peripheral part is effective when larger, but 1/3 or so is also abundant.In addition, herein
Reflectivity not instead of positive reflection ratio, the ratio of scattered reflection, the white portion at center is by irradiation light compared with big angle
Spend the scattering surface of scattering.
The movement of present embodiment formed as described above is illustrated.
The sample of the check objects such as blood or urine is contained in sample container 10 and is placed in sample disc 12 by operator.So
Afterwards, if in computer 61 input start analysis processing instruction, using sample dispense probe 15a by a certain amount of sample from
Sample container 10 is dispensed into the reaction vessel 35 of reaction tray 36, will be certain using first and second reagent dispenser 20,21
The reagent of amount is dispensed into reaction vessel 35 from reagent container 40, is stirred using agitating device 30.In addition, sample and reagent
Dispense volume preset by each analysis type.Reaction tray 36 is periodically repeated rotation and stops, in reaction vessel
35 carry out survey light using spectrophotometric detector 51 with the timing in the front of light source 50 by measurement.In the preset phase in reaction time
Between survey light is repeated, later, the discharge and cleaning of the reaction solution in reaction vessel 35 are carried out with cleaning container mechanism 45.This
Outside, in another reaction vessel 35, while used the movement of another sample and reagent.With spectrophotometric detector 51 into
The data that row surveys light are sent in computer 61 and carry out operation, calculate the concentration of ingredient corresponding with analysis type and display
In display unit 61e.
In above-mentioned analysis movement, by being dispensed in reagent from the reagent dispense probe 20a of the first reagent dispenser 20
When into reaction vessel 35, a certain amount of liquid is discharged from constant displacement pump 25, so that reagent 22 is from the front end of reagent dispense probe 20a
It is discharged to reaction vessel 35.Defined multiple timings make flashlight 66 shine during until start to be expelled to end, use
The image of its moment of camera shooting of photographic device 65.The image of camera shooting is sent in computer 61 via controller 60, passes through image point
Analysis and differentiate dispensing have it is without exception, if showing alarm in an exceptional case judging to deposit.
Image procossing in present embodiment for example carries out as follows.
The region for extracting reagent 22 out from image shown in Fig. 8, calculates the liquid from the front end of reagent dispense probe 20a
Length (blob length) L.
Figure 10 is the figure for indicating an example of the measurement result of blob length of reagent.
In Figure 10, if starting to be discharged, blob length L is changed in 5mm between 10mm, is restored to if end is discharged
0mm.This is the chart in the normal situation of discharge, but occurs different waveforms in the event of an abnormality.For example, trying
In the case where the attraction failure of agent, blob length L or original 0mm.In addition, having attracted bubble in the midway that reagent attracts
In the case of, blob length L cannot maintain always 5mm or more until discharge terminates, but intermittently.In addition, in bubble
In the case where in into dispensing runner, or in the case where dispensing the generation leakage of runner 24, in the rise and fall of blob length L
Upper generation lag.In this way, the waveform of blob length L changes according to the abnormal type of attraction, therefore by extracting out from waveform
Feature variable and carry out discriminant analysis, it is abnormal can accurately to detect dispensing.
In addition it is also possible to without image procossing, and only retain the record of image data.In this case, it saves and just opens
The image for beginning after being discharged and being discharged after just terminating.In the case where needing confirmation after analysis terminates, with analysis result one
And show the image of discharge.At this point, being shown with discharge graphical arrangement when analysis before having been carried out with identical reagent.Especially
It, arranges display as referring to image for the discharge image when reagent being used to be calibrated.
In this case, can retain proves that dispensing movement is normal data.In addition, at without complicated image
Reason, therefore the load of computer 61 can be reduced.In addition, can compared with the discharge image in the case where correct discharge, because
Even the operator of this lack of experience can also be easy to carry out normal or abnormal judgement.In addition, will be when beginning to use reagent
Discharge image when the calibration of progress is used as referring to image, and can judge whether dispensing is normal based on the analysis results, therefore join
According to the high reliablity of image.In addition, can be set as only saving two images in discharging operation, therefore data can be reduced
Amount.
The effect of present embodiment formed as described above is illustrated.
In the automatic analysing apparatus of qualitative and quantitative analysis for carrying out the organism samples such as blood or urine, examination will be contained in
Sample in sample container is dispensed into reaction vessel etc. with the reagent being contained in reagent container and it is made to be reacted and be carried out
Analysis is accurately analyzed in order to obtain as a result, it is essential for carrying out normal dispensing to reaction vessel from each container.But
It is, it is colorless and transparent also more in handled sample or reagent in automatic analysing apparatus, object is dispensed in the prior art
Be it is colorless and transparent in the case where the contrast of image be lower, it is difficult to accurately determine the exception of dispensing.
Fig. 9 is the comparative example as present embodiment and the figure in the discharge process of reagent that indicates, is that indicate will be in Fig. 5
Screen angle α be set as 120 degree or more and the figure of example that is imaged.
As shown in figure 9, in the prior art dispensing object be it is colorless and transparent in the case where the contrast of image be lower, it is difficult to
Accurately determine the exception of dispensing.
In this regard, in the present embodiment, comprising: be inserted into reagent dispense probe 20a, 21a and accommodate dispensing object
In the reagent container 40 of reagent and after attracting reagent, reagent dispense probe 20a, 21a is inserted into reaction vessel 35 side by side
First and second reagent dispenser 20,21 of reagent 22 out；To from the front end of reagent dispense probe 20a, 21a to reaction vessel
The photographic device 65 that the position of 35 discharge reagents 22 is imaged；And with opposed with photographic device 65 across reaction vessel 35
The screen 75 that mode configures, which, which has to be configured at extending in the up and down direction, utilizes the camera shooting of photographic device 65
The bright portion 76 of at least central portion in region and be configured at bright portion 76 at least side a side and brightness than bright portion 76
Low dark portion 77, therefore just can determine the exception of dispensing not against the color or transparency of dispensing object, can be improved point
The reliability of analysis.
That is, in the present embodiment, there is the screen 75 in bright portion 76 and darkness portion 77 with the irradiation of flashlight 66, will come from
The scattering light of screen 75 is imaged as background and to the reagent 22 being discharged from reagent dispense probe 20a, 21a, therefore can
It is imaged with shape of the high contrast to reagent 22.
In addition, in case of the present embodiment, it is wider than the mobile width of reagent 22 with the width in the bright portion 76 of screen 75
Mode set, therefore in the visual field of photographic device 65 reagent 22 background become uniform white area, can clearly distinguish
The shape of other reagent 22.
In addition, flashlight 66 be set as according to the order instant from controller 60 shine light-pulse generator, therefore even if
In the shutter release time longer situation of photographic device 65, moment image also can be effectively imaged, and fill as camera shooting
Set the device for the low price that 65 can also use sensitivity low.
In addition, due to being configured to divide from first and second reagent using the control camera shooting timing of controller 60
The specific timing of the process of reagent dispense probe 20a, the 21a discharge reagent 22 of dispensing device 20,21 is accurately imaged.Especially
Its, investigate be discharged since constant displacement pump 25 is just after and discharge just terminate after two timings discharge liquor (reagent 22)
In the case where shape, the case where reagent dispense probe 20a, 21a does not attract reagent normally from reagent container 40 can be differentiated, therefore
It is highly effective.
In addition, not being to analyze continuously to take the photograph during the discharging operation of the reagent 22 from reagent dispense probe 20a, 21a
The animation of picture, but the still picture of specific timing is analyzed, therefore the operation time of image procossing can be shortened, and as note
The image recorded and saved is only a small number of still picture, can be realized data capacity reduction.
In addition, flashlight 66 only shines in camera shooting timing, therefore influenced most caused by the reaction solution in reaction vessel 35
It is small.In addition, survey in spectrophotometric detector 51 timing of light, flashlight 66 does not shine, therefore will not make to spectrophotometric detector 51
At stray light, it is able to carry out analysis with high accuracy.
In addition, flashlight 66 only shines in camera shooting timing, therefore calorific value is small, to the temperature of the recirculated water 39 of thermostat 37
Caused by influence it is small.In addition, being only configured with the optical system of camera shooting in a side of thermostat 37, therefore can also be appropriate
Ground is configured at around the dispensing mechanism for the automatic analysing apparatus that multiple mechanisms concentrate.In particular, being configured in the outside of thermostat 37
The driving mechanism of first and second reagent dispenser 20,21 or wiper mechanism (not shown) etc., thus by flashlight 66 with take the photograph
As device 65 is configured at the inner circumferential side of thermostat 37 in the same manner, so that the configuration of each mechanism becomes easy, automatic point can be realized
The miniaturization of analysis apparatus.Additionally it is possible to which flashlight 66 to be configured to the outside of thermostat 37, screen 75 is configured at thermostat
37 inner circumferential side.
In addition, flashlight 66 irradiates screen 75 from the oblique transverse direction of photographic device 65 or obliquely downward, thus screen 75 not
Form the shadow of reagent dispense probe 20a, 21a, it will be able to obtain the image of identical background.
Second embodiment
1 pair of second embodiment of the present invention is illustrated referring to Fig.1.
Photographic device is configured at the inner circumferential side of reaction tray relative to first embodiment by present embodiment, by flashlight
It is configured at the front of screen.
Figure 11 is to extract the camera shooting processing unit for carrying out camera shooting processing of present embodiment out together with surrounding structure and indicate
Figure.Component same as the first embodiment marks identical appended drawing reference in figure, and omits the description.
In Figure 11, thermostat 37 is configured to, recirculated water 39 along the movement routine of reaction vessel 35 riddle wherein,
The side wall of the inside (the i.e., inner circumferential side of reaction tray 36) of movement routine is configured with the transmission being made of the transparent component of transmitted light
Window 47.
It is equipped in camera shooting processing unit 80A: to via being set to the constant temperature configured in a manner of the periphery for surrounding reaction tray 36
Liquid (reagent is discharged from the front end of reagent dispense probe 20a to reaction vessel 35 in transmissive window 47 on the side wall of the inside of slot 37
22) photographic device 65 that position is imaged；With the screen configured across the mode opposed with photographic device 65 of reaction vessel 35
Curtain 75A (background portion)；And the flashlight 66A as light source, photographic device 65 and flashlight 66A are connect with controller 60.
Screen 75A is configured at the movement routine of the reaction vessel 35 in thermostat 37 in the mode opposed with photographic device 65
Outside (the i.e., peripheral side of reaction tray 36) side wall movement routine side, as bright portion flashlight 66A with vertically side
At least central portion in the region imaged using photographic device 65 is configured to the mode of extension, at bright portion (flashlight 66A)
An at least side of the side dark portion 77 lower than bright portion configured with brightness (or brightness).
As flashlight 66A, such as to be able to use slim face light-emitting LED.In addition, even if scatterer and side in planar
Identical effect can be also obtained in the combination of the LED of face irradiation.In addition, screen 75A also can be made uniform black side, and
Flashlight 66A is configured at center.
Other structures are identical with first embodiment.
Even if can also obtain effect same as the first embodiment in present embodiment formed as described above.
In addition, be the light directly luminous in the behind of reaction vessel 35 with the bias light that photographic device 65 is shot, therefore from
The shadow of the reaction vessel 35 or reagent dispense probe 20a that generate when external irradiation light does not mirror image and becomes uniform back
Scape, therefore image can be clearly discharged.
In addition, not via 47 irradiation light of transmissive window, therefore transmissive window 47 can be made smaller, the temperature control to recirculated water 39
It is formed with benefit.
Further, it is possible to avoid the irradiation light from flashlight 66A from reflecting in transmissive window 47 and become the miscellaneous of photographic device 65
Astigmatism.
In addition, directly configuring light source in the comparable part (screen 75A) of background with discharge image, therefore pulse can be made
The luminous intensity of lamp 66A becomes smaller, and can be improved camera shooting efficiency, and flashlight 66A can be to be realized with a low cost, also, can also
Enough influences reduced to spectrophotometric detector 51.
Third embodiment
2 pairs of third embodiment of the present invention are illustrated referring to Fig.1.
Photographic device is configured at the inner circumferential side of reaction tray relative to first embodiment by present embodiment, and is being tried
Agent dispenses the width of flow path that position expands thermostat, increases screen at a distance from reaction vessel.
Figure 12 is to extract the camera shooting processing unit for carrying out camera shooting processing of present embodiment out together with surrounding structure and indicate
Figure.Component same as the first embodiment marks identical appended drawing reference in figure, and omits the description.
In Figure 11, thermostat 37 is configured to, recirculated water 39 along the movement routine of reaction vessel 35 riddle wherein,
The side wall of the inside (the i.e., inner circumferential side of reaction tray 36) of movement routine is configured with the transmission being made of the transparent component of transmitted light
Window 47.
It is equipped in camera shooting processing unit 80B: to via being set to the constant temperature configured in a manner of the periphery for surrounding reaction tray 36
Liquid (reagent is discharged from the front end of reagent dispense probe 20a to reaction vessel 35 in transmissive window 47 on the side wall of the inside of slot 37
22) photographic device 65 that position is imaged；The screen 75 configured in a manner of across reaction vessel 35 and photographic device 65
(background portion)；And from 65 side of photographic device via transmissive window 47 to the arteries and veins as light source of the direction irradiation light of reaction vessel 35
Jump lights 66, photographic device 65 and flashlight 66 are connect with controller 60.
Screen 75 is configured at the movement routine of the reaction vessel 35 in thermostat 37 in the mode opposed with photographic device 65
Outside (the i.e., peripheral side of reaction tray 36) side wall movement routine side, and have extending in the up and down direction
It is configured at the bright portion 76 of at least central portion in the region imaged using photographic device 65 and is configured at at least side in bright portion 76
A side and brightness (or brightness) for side the dark portion 77 lower than bright portion 76.
The width of flow path of recirculated water 39 in thermostat 37 broadens in the setting position of screen 75, from reagent dispense probe
The reagent 22 of 20a discharge is elongated at a distance from screen 75.The part is referred to as magnification region.
Other structures are identical with first embodiment.
In present embodiment formed as described above, effect same as the first embodiment can be obtained.
In addition, can setting screen angle α it is smaller, therefore the high discharge image of contrast can be obtained.
In addition, imaging the part other than processing unit 80B, the runner that can reduce the recirculated water 39 in thermostat 37 is wide
Degree, there is no need to increase the amount of recirculated water 39, size reduction of an apparatus can be attained and the reduction of running cost.
4th embodiment
3 pairs of the 4th embodiments of the invention are illustrated referring to Fig.1.
Photographic device is configured at the inner circumferential side of reaction tray relative to first embodiment by present embodiment, by flashlight
It is configured at the behind of the screen with transmissive window.
Figure 13 is to extract the camera shooting processing unit for carrying out camera shooting processing of present embodiment out together with surrounding structure and indicate
Figure.Component same as the first embodiment marks identical appended drawing reference in figure, and omits the description.
In Figure 13, thermostat 37 is configured to, recirculated water 39 along the movement routine of reaction vessel 35 riddle wherein,
The side wall of the inside (the i.e., inner circumferential side of reaction tray 36) of movement routine is configured with the transmission being made of the transparent component of transmitted light
Window 47.
It is equipped in camera shooting processing unit 80C: to via being configured at the constant temperature configured in a manner of the periphery for surrounding reaction tray 36
Liquid (reagent is discharged from the front end of reagent dispense probe 20a to reaction vessel 35 in transmissive window 47 on the side wall of the inside of slot 37
22) photographic device 65 that position is imaged；With the screen configured across the mode opposed with photographic device 65 of reaction vessel 35
Curtain 75C (background portion)；And the flashlight 66C as light source, photographic device 65 and flashlight 66C are connect with controller 60.
Screen 75C is configured at the movement routine of the reaction vessel 35 in thermostat 37 in the mode opposed with photographic device 65
Outside (the i.e., peripheral side of reaction tray 36) side wall movement routine side, transmissive window 48 is configured to be taken the photograph using photographic device 65
At least central portion in the region of picture.It is configured with flashlight 66C in the behind (outside) of transmissive window 48, by transmissive window 48 and flashlight
66C plays the function as bright portion.In the left and right of bright portion (transmissive window 48) and up and down configured with brightness (or brightness)
The dark portion 77 lower than bright portion.
As flashlight 66C, such as to be able to use slim face light-emitting LED.
Other structures are identical with first embodiment.
Even if effect same as the first embodiment can be obtained in present embodiment formed as described above.
In addition, flashlight 66C does not enter among recirculated water 39, therefore flashlight 66C does not need waterproof, can reduce into
This.
In addition, flashlight 66C can be configured at except thermostat 37, therefore it is easy to carry out the replacement of flashlight 66C, energy
Enough improve maintainability.
In addition, the central area of the background of discharge image is determined by the shape of transmissive window 48, therefore it can arbitrarily form arteries and veins
It jumps lights the shape of 66C, is able to use cheap universal product.
In addition, the position of flashlight 66C can be made far from the reagent 22 being discharged from reagent dispense probe 20a, therefore can
Increase screen angle α, image can be clearly discharged.
5th embodiment
4 pairs of the 5th embodiments of the invention are illustrated referring to Fig.1.
Present embodiment changes the color and configuration in the dark portion of screen relative to first embodiment.
Figure 14 is figure the case where indicating to be observed from the front the screen of present embodiment.In figure with first embodiment phase
Same component marks identical appended drawing reference, and omits the description.
In Figure 14, the screen 75D (background portion) of present embodiment includes the area for being configured at and imaging using photographic device 65
The bright portion 76 of at least central portion in domain；It is configured at at least left and right sides in bright portion 76, and brightness (or brightness) is compared
The first low darkness portion 77a of bright portion 76；It is configured at the upside in bright portion 76, and brightness (or brightness) is than bright portion 76
The second low darkness portion 77b；And it is configured at the downside in bright portion 76, and brightness (or brightness) is lower than bright portion 76
Third darkness portion 77c.
The bright portion 76 of screen 75D and darkness portion 77a, 77b, 77c are not limited to white and black and are distinguished with colour.
Bright portion 76 is made of the bright color close with white, and the first darkness portion 77a is made of color unlike this, and second
And third darkness portion 77b, 77c is made of other different colors.Color image is obtained in addition, having as photographic device 65
Function carries out image procossing according to the picture signal from photographic device 65 in controller 60 and using colouring information.
Other structures are identical with first embodiment.
Even if can also obtain effect same as the first embodiment in present embodiment formed as described above.
In addition, the region (i.e., the comparable part of profile with the left and right of reagent 22 of image) to bend right and left in reagent 22
It is imaged with the color of the first darkness portion 77a, (i.e., image is upper and lower with reagent 22 in upper and lower curved region in reagent 22
The comparable part of profile) imaged with the color of the second darkness portion 77b and third darkness portion 77c.So as to according to face
The information of the shape of the acquisition of information reagent 22 of color.
In addition, the front end of reagent dispense probe 20a or other foreign matters become shadow and are imaged, in contrast, reagent
22 become the shadow with colored profile and are imaged, therefore can clearly judge the state of reagent 22.
Sixth embodiment
5 the sixth embodiment of the present invention is illustrated referring to Fig.1.
Camera shooting processing unit is also set to the discharge position of sample dispense probe relative to first embodiment by present embodiment
It sets.
Figure 15 is the figure for schematically indicating the image of reaction vessel of present embodiment.In figure with first embodiment phase
Same component marks identical appended drawing reference, and omits the description.
In the present embodiment, photographic device 65 is not set to the position of the first reagent dispenser 20 instead of, setting
In the drain position of the sample of the sample dispense probe 15a of sample dispenser 15.Sample from sample dispense probe 15a
The camera shooting of 22D carries out not instead of in discharge process, carries out after discharge terminates.After discharge terminates, sample 22D at
For be attached to reaction vessel 35 bottom state, its shape is imaged.
Other structures are identical with first embodiment.
Even if can also obtain effect same as the first embodiment in present embodiment formed as described above.
Even in addition, micro sample 22D, shape are also imaged with high contrast, therefore can monitor examination
Sample can clearly judge whether correctly to dispense to the dispensing state of reaction vessel 35.
7th embodiment
6 pairs of the 7th embodiments of the invention are illustrated referring to Fig.1.
Present embodiment images reaction vessel in the rotary course of reaction tray relative to first embodiment.
Figure 16 is the figure for schematically indicating the image of reaction vessel of present embodiment.In figure with first embodiment phase
Same component marks identical appended drawing reference, and omits the description.
In the present embodiment, just send out flashlight 66 in the timing that reaction vessel 35 passes through when rotated in reaction tray 36
Light is simultaneously imaged using photographic device 65.The reaction solution for accommodating dispensing sample and reagent in reaction vessel 35 and stirring
23.In the example of Figure 16, the case where air entrapment 33, blibbing 32, attachment liquid 34 are generated in reaction solution 23 is instantiated.
Air entrapment 33, blibbing 32, attachment liquid 34 are transparent bubble or liquid grain, but pass through the light carried out accordingly
Refraction, clear image can be imaged, thus be able to use image discriminating to analysis result impact a possibility that.
Other structures are identical with first embodiment.
Even if can also obtain effect same as the first embodiment in present embodiment formed as described above.
In addition, more than discharge state, additionally it is possible to detect the exception occurred when stirring bad.
Additionally, this invention is not limited to above-mentioned each embodiments, but include various modifications example.For example, above-mentioned embodiment party
Formula is described in detail to illustrate the present invention understandablely, not necessarily have it is stated that all structures.
Claims (13)
1. a kind of automatic analysing apparatus comprising:
Dispenser, pass through accommodate dispensing object liquid container in be inserted into dispense probe and attract aforesaid liquid it
Afterwards, above-mentioned dispense probe is inserted into reaction vessel and is discharged aforesaid liquid, to dispense the liquid of above-mentioned dispensing object；
Photographic device is imaged to from the front end of above-mentioned dispense probe to the position of above-mentioned reaction vessel discharge aforesaid liquid；
Background portion to configure across the above-mentioned reaction vessel mode opposed with above-mentioned photographic device, and has with vertically side
The bright portion of at least central portion in the region imaged using above-mentioned photographic device is configured to the mode of extension and is configured at above-mentioned
One side of at least side in bright portion and the brightness dark portion lower than above-mentioned bright portion；
Based on to the image real-time image processing shot using above-mentioned photographic device as a result, determining to be carried out by above-mentioned dispenser
Aforesaid liquid the determination unit that whether normally implements of dispensing；And
It, will in the case where the dispensing that above-mentioned determination unit determines the aforesaid liquid carried out by above-mentioned dispenser is not implemented normally
The abnormal notice of the dispensing of aforesaid liquid to operator notification unit,
Wherein, above-mentioned image procossing is the length for going out the aforesaid liquid being discharged from above-mentioned dispense probe according to above-mentioned image detection
Processing.
2. automatic analysing apparatus according to claim 1, which is characterized in that
Light source with the direction irradiation light from from above-mentioned image capture device side to above-mentioned reaction vessel.
3. automatic analysing apparatus according to claim 2, which is characterized in that
Above-mentioned light source is configured at the position position on the lower than above-mentioned photographic device.
4. automatic analysing apparatus according to claim 1, which is characterized in that
The bright portion of above-mentioned background portion has the function as light source to above-mentioned reaction vessel irradiation light.
5. automatic analysing apparatus according to claim 1, which is characterized in that
Above-mentioned photographic device images the case where liquid that above-mentioned dispensing object is discharged from above-mentioned dispense probe.
6. automatic analysing apparatus according to claim 5, which is characterized in that
Above-mentioned photographic device is after the liquid of the above-mentioned dispensing object from above-mentioned dispense probe has just started discharge or is discharged
It is imaged after just stopping.
7. automatic analysing apparatus according to claim 1, which is characterized in that
Above-mentioned photographic device is to the transmissive window via the side wall for being set to thermostat from the front end of above-mentioned dispense probe to above-mentioned anti-
The position of container discharge aforesaid liquid is answered to be imaged, above-mentioned thermostat there are multiple above-mentioned reactions to surround circumferentially to be arranged
The mode of the periphery of the reaction tray of container configures.
8. automatic analysing apparatus according to claim 1, which is characterized in that
The width in the bright portion of above-mentioned background portion is set are as follows: than what is be discharged from the front end of above-mentioned dispense probe to above-mentioned reaction vessel
The mobile width of the horizontal direction of aforesaid liquid is wide, and connects the position of above-mentioned dispense probe in the horizontal direction respectively and above state clearly
It is 80 degree or less that the line segment at the both ends of the width direction of highlights, which is formed by angle,.
9. automatic analysing apparatus according to claim 1, which is characterized in that
Above-mentioned background portion also has the dark portion for the two sides up and down for being configured at above-mentioned bright portion.
10. automatic analysing apparatus according to claim 1, which is characterized in that
The storage unit that image with the judgement that will be used for above-mentioned determination unit is associated with result is determined and stores.
11. automatic analysing apparatus according to claim 1, which is characterized in that
Above-mentioned automatic analysing apparatus has display unit,
Above-mentioned display unit has the function of as follows: by using above-mentioned determination unit determine in abnormal situation from above-mentioned point
It infuses the image of aforesaid liquid and the graphical arrangement in the case where determining normal situation in advance that probe is discharged and shows.
12. automatic analysing apparatus according to claim 7, which is characterized in that
In the allocation position of the above-mentioned background portion of the opposite side for the above-mentioned transmissive window for being set to above-mentioned thermostat, have for expanding
Magnification region of the above-mentioned reaction vessel at a distance from above-mentioned background portion.
13. a kind of image capture method, including following process:
After being inserted into dispense probe in accommodating the container of liquid of dispensing object and attracting aforesaid liquid, by above-mentioned point
Note probe is inserted into reaction vessel and is discharged aforesaid liquid, to dispense the liquid of above-mentioned dispensing object；And
It is taken the photograph using photographic device to from the front end of above-mentioned dispense probe to the position of above-mentioned reaction vessel discharge aforesaid liquid
Picture,
Above-mentioned image capture method is characterized in that,
To configure background portion across the above-mentioned reaction vessel mode opposed with above-mentioned photographic device,
The background portion has is configured at the region for utilizing the shooting of above-mentioned photographic device at least extending in the up and down direction
The bright portion of central portion and a side of at least side for being configured at above-mentioned bright portion and the brightness darkness lower than above-mentioned bright portion
Portion,
Based on to the image real-time image processing shot using above-mentioned photographic device as a result, determining aforesaid liquid by determination unit
Dispensing whether normally implement；And
In the case where above-mentioned determination unit determines the dispensing of aforesaid liquid and do not implement normally, by notification unit by aforesaid liquid
The abnormal notice of dispensing to operator,
Above-mentioned image procossing is the processing for going out the length for the aforesaid liquid being discharged from above-mentioned dispense probe according to above-mentioned image detection.
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| JP2015-127851 | 2015-06-25 | ||
| JP2015127851A JP6444817B2 (en) | 2015-06-25 | 2015-06-25 | Automatic analyzer and imaging method |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2017009532A (en) | 2017-01-12 |
| JP6444817B2 (en) | 2018-12-26 |
| CN106290153A (en) | 2017-01-04 |
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