CN106289933B - Cover body and device for storing and mixing solid and liquid - Google Patents
Cover body and device for storing and mixing solid and liquid Download PDFInfo
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- CN106289933B CN106289933B CN201510276416.0A CN201510276416A CN106289933B CN 106289933 B CN106289933 B CN 106289933B CN 201510276416 A CN201510276416 A CN 201510276416A CN 106289933 B CN106289933 B CN 106289933B
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Abstract
The invention relates to a cover body for storing and mixing liquid or solid, which is characterized in that the cover body comprises an upper cover and a lower cover, wherein the upper cover is movably connected with the lower cover; the lower cover comprises a sealed cavity; the upper cover comprises a puncture and sealing structure for puncturing and sealing the sealing cavity of the lower cover. The mixing cover body and the mixing device comprising the same can realize the function of mixing liquid or solid, particularly mixing liquid and solid at any time when in use, and can also realize quantitative mixing. The problem of inaccurate to follow-up detection that uses after mixing earlier and storing is solved. And the operation is simple and the use is convenient.
Description
Technical Field
The present invention relates to a cap for storing and mixing liquids or solids and a mixing device therefor, and in particular to a cap for storing and mixing a liquid and other liquids or solids and a mixing device therefor.
Background
The following background is provided to aid the reader in understanding the present invention and is not admitted to be prior art.
The technology of detecting whether an analyte exists in a sample by using the principle of an immunological binding reaction is widely used in various fields. It can be used to detect analytes in various biological samples (saliva, blood, urine, serum, sweat, etc.) to monitor diseases and human health (early pregnancy, tumors, infectious diseases, drugs, etc.). The underlying principle of such detection techniques is to establish the ability to specifically bind between immune molecules, such as antibodies and antigens, haptens/antibodies, biotin and avidin, and the like. In addition, many such assays can be performed on solid media, such as conventional lateral flow reagent strips, in glass or plastic porous disks, immunochromatographic devices, and the like. Usually, some solid particles or chemical substances can be further combined on the immune specific binding molecules, so that the detection result can be qualitatively, quantitatively or semi-quantitatively obtained by naked eyes or other instrument devices.
Test strips or devices that utilize these principles are found in the prior art, such as those described in the following patents: US 4857453; US 5073484; US 5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US 5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US 6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US 6352862; US 6372515; US 6379620; and US 6403383.
In the detection of such biological samples, it is often necessary to pre-treat the biological sample so that the components of the sample to be analyzed are released. Therefore, the pretreatment or buffer treatment of the sample becomes an essential key step for ensuring the accuracy or precision of the detection result.
In some assays, the assay sample is pretreated by adding a buffer solution. The buffer solution for buffering is generally composed of one substance or a mixture of 2 or more solid or liquid substances. In some detection, two substances are mixed to form a buffer solution to buffer a sample, but the two substances can react after being mixed in advance, or the two substances are not easy to store for a long time, or the buffer effect is greatly reduced after the two substances are stored for a long time, and even the subsequent detection is inaccurate. Therefore, it is necessary to be able to mix the samples immediately when they need to be buffered.
Disclosure of Invention
The invention provides a cover body for storing and mixing liquid or solid and a mixing device comprising the cover body.
The invention provides a cover body for storing and mixing liquid or solid, which comprises an upper cover and a lower cover, wherein the upper cover and the lower cover are movably connected; the lower cover comprises a sealed cavity; the upper cover comprises a puncture and sealing structure for puncturing and sealing the sealing cavity of the lower cover. Wherein, the sealed cavity in the lower cover is used for storing liquid.
In some preferred embodiments, the upper cover has a first position and a second position on the lower cover; when the upper cover is at the first position, the puncture and sealing structure is positioned at the upper surface of the sealing cavity and does not contact the upper surface; when the upper cover moves from the first position to the second position, the puncture and sealing structure contacts the upper surface of the sealing cavity, punctures and seals the surface, enters and presses the sealing cavity, and leads the liquid in the sealing cavity to flow out; when the upper cover is positioned at the second position, the puncture and sealing structure is completely positioned in the sealing cavity.
The liquid sealed in the lower cover can be transferred to the upper cover through the movement between the upper cover and the lower cover, and the solid or the liquid can be originally stored in the upper cover, so that the mixing of two liquids or one liquid and one solid can be realized. That is, the liquid is transferred from the sealed cavity of the lower cover to the upper cover in the process of mutually moving the upper cover and the lower cover, which becomes the key point for realizing the mixing of the liquid or the solid. In the invention, the sealing cavity is punctured and sealed by the puncturing and sealing structure on the upper cover, and the sealing cavity is moved and extruded in the sealing cavity, so that liquid flows out of the cavity due to pressure and then reaches the upper cover, thereby realizing the function of liquid transfer. Specifically, first, the puncture and seal structure punctures the surface of the seal cavity, so that the seal cavity is communicated with the upper cover; the puncture and sealing structure punctures and seals the punctured surface of the sealing cavity at the same time, so that the sealing cavity is sealed again except for the channel communicated with the upper cover; and finally, the puncture and sealing structure continues to move towards the bottom of the cavity, and the sealing cavity is squeezed to enable the liquid to flow out of the upper cover along the channel after being pressed. That is, when the upper cover is in the first position, the solid or liquid on the upper cover and the lower cover are respectively stored, so as to realize the storage function of the cover body, and at the moment, the puncture and seal structure is positioned at the upper surface of the seal cavity and does not contact the upper surface; when the upper cover is at the second position, the cover body realizes the mixing function, at the moment, the puncture and sealing structure is completely positioned in the sealing cavity, and all or most of the liquid in the cavity is extruded to flow into the upper cover and is mixed with the liquid or solid previously stored in the upper cover; the process that the upper cover moves from the first position to the second position is the mixing process of liquid or solid, at the moment, the puncture and sealing structure punctures and seals the surface after contacting the upper surface of the sealing cavity, and gradually enters and presses the sealing cavity, so that the liquid in the sealing cavity flows into the upper cover and is gradually mixed with the liquid or solid in the upper cover.
In some embodiments, the piercing and sealing structure comprises a conical projection. The bulge is conical, and when the sharp bulge at the top end can puncture the surface of the sealed cavity, the volume of the liquid entering the sealed cavity is gradually increased, namely the volume of the sealed cavity is gradually reduced, so that the liquid in the sealed cavity is compressed or flows out gradually, and the phenomenon of slow outflow or sudden blowout is avoided.
Preferably, the puncture and seal structure further comprises a cylindrical body attached to the end of the conical projection.
More preferably, the diameter of the cylinder is the same as the inner diameter of the sealed cavity.
In other embodiments, the puncture and seal structure further comprises a neck cylinder connected between the protrusion and the cylinder. Therefore, the projection and the cylinder can be smoothly connected, and the puncturing device can extrude the cavity to ensure that liquid flows out without causing the spray condition caused by sudden pressure increase suddenly due to space reduction.
The cylinder forms a seal with the side wall of the seal cavity after entering the seal cavity, so that the puncture and seal structure becomes a piston, the cylinder moves along the inner side wall of the seal cavity in the downward movement process in the seal cavity, the space of the rest seal cavity is always in a seal state and is not continuously reduced, so that enough pressure is kept in the cavity, and the liquid in the cavity flows out of the cavity until the puncture and seal structure is full of the seal cavity.
In order to ensure that the liquid in the sealed chamber is adequately transferred out, in a particular embodiment, the length of the conical projection is less than half the length of the sealed chamber.
In some embodiments, the puncture and seal structure further comprises a channel that communicates liquid within the seal cavity into the overcap.
More specifically, the passage opening is located on a conical projection. This allows the passage to be in fluid communication with the chamber for the first time.
In other embodiments, the upper surface of the sealed housing comprises a pierceable membrane or rubber.
In some specific embodiments, the cover body comprises a clamping strip for preventing the upper cover and the lower cover from moving; the clamping strip is separable from the cover body.
When the clamping strip is fixed on the cover body, the upper cover and the lower cover cannot move or move relatively, and at the moment, the upper cover is positioned at the first position of the lower cover; after the clamping strip is taken down from the cover body, the upper cover and the lower cover can move mutually, specifically, the upper cover can move towards the bottom of the lower cover along the lower cover and finally reaches the second position.
In some embodiments, the upper cover and the lower cover are connected by screw threads, that is, the upper cover and the lower cover are moved by screwing the screw threads.
In another aspect, the present invention further provides a device for storing and mixing solid and liquid, comprising a device body and a cover body of the present invention, wherein the device body is connected with the upper cover of the cover body and is in liquid communication with the upper cover.
In a more specific form, the passage of the puncture and seal structure is in fluid communication with the device body.
The device body is connected and communicated with the upper cover, so that liquid entering the upper cover can also enter the device body, solid or liquid can be contained in the device body, and the entering liquid is mixed with the original liquid or solid. More specifically, the liquid can be introduced into the device body by directly communicating with the device body through the passage of the puncture and seal structure.
Advantageous effects
The mixing cover body and the mixing device comprising the same can realize the function of mixing liquid or solid, particularly mixing liquid and solid at any time when in use, and can also realize quantitative mixing. The problem of inaccurate to follow-up detection that uses after mixing earlier and storing is solved. And the operation is simple and the use is convenient.
Drawings
FIG. 1 is a schematic view of a cover of the present invention;
FIG. 2 is a schematic view of a storage and mixing apparatus of the present invention;
FIG. 3 is a schematic view of the separation of the card strip from the cover;
FIG. 4 is a schematic cross-sectional view of the upper cover of the apparatus of FIG. 2 in a first position of the lower cover;
FIG. 5 is a schematic cross-sectional view of the device of FIG. 2 with the clamping strip removed;
fig. 6 is a schematic cross-sectional view of the device of fig. 2 showing the relative movement of the upper and lower covers.
Description of reference numerals:
a cover body 100; a mixing device 800; a lower cover 110; an upper cover 120; a buckle 130; a device main body 200; a main body upper cover 210; a liquid 300 in the lower cap; a sealed cavity 112 of the lower cover; a sealing surface 113 sealing the cavity; an upper cover internal thread 121; piercing and sealing structure 122 projection 1221; a cylinder 1222; a bottleneck cylinder 1223; a channel 1224; a passage opening 1225; a solid 400; lower cover external thread 111
Detailed Description
The present invention will be further described with reference to the structures or terms used herein. In the following detailed description, reference is made to the accompanying drawings that form a part hereof, and in which is shown by way of illustration specific embodiments in which the invention may be practiced. It is not excluded that the invention can also be implemented in other embodiments and that the structure of the invention can be varied without departing from the scope of use of the invention.
In the present invention, the cover body 100 is divided into two parts: the upper cover 120 and the lower cover 110 are movably connected. In the initial state, the upper cover 120 and the lower cover 110 are fixedly coupled together, so that the liquid or solid can be separately stored in the cover body 100 without changing the state. And the upper cap 120 and the lower cap 110 are moved or moved relative to each other, so that the solid or liquid respectively stored in the upper cap 120 and the lower cap 110 can be mixed. In one embodiment, as shown in fig. 1, the upper cap 120 and the lower cap 110 are coupled together by engaging the internal and external threads, and the upper cap 120 and the lower cap 110 are fixed by a snap 130 so as not to move relative to each other. The latch 130 is positioned on the lower cover 110 such that the bottom of the upper cover 120 is spaced apart from the bottom of the lower cover 110. When it is required to move the upper cap 120 and the lower cap 110 to each other, the latch 130 is removed from the cap body 100, as shown in fig. 3, and the upper cap 120 is rotated downward, so that the upper cap 120 can move on the lower cap 110.
As shown in the cross-sectional view of fig. 4, a sealed chamber 112 is included in the lower cap 110, and the sealed chamber 112 is filled with a liquid solution 300, such as a buffer solution. The bottom and the side wall of the sealed cavity 112 are an integral structure and are located in the cavity of the lower cover 110, and the upper surface 113 of the sealed cavity is sealed by a sealing film or sealing rubber. The sealing film or the sealing rubber can be punctured by a sharp object so as to facilitate the communication between the liquid in the cavity and the outside.
On the upper cap 120, a piercing structure 122 capable of piercing and sealing the upper surface of the chamber is included, as also shown in fig. 4 or 5, and specifically, the piercing and sealing structure 122 is composed of three parts connected together: a conical projection 1221, a bottleneck cylinder 1223 and a cylinder 1222. A conical projection 1221, the main function of which is to pierce the sealing film or rubber of the surface 113 of the sealed cavity and to seal the surface 113 therewith; the bottle neck cylinder 1223 has one end with a small diameter connected to the end of the projection 1221 and the other end connected to the cylinder 1222, and the cylinder 1222 is mainly used to seal the surface 113 of the sealed cavity 112 and further seal the side wall of the sealed cavity 112, so that the space of the sealed cavity 112 is sealed and reduced, and the liquid 300 in the cavity 112 is squeezed out. The diameter of the cylinder 1222 is the same as the inner diameter of the sealed housing 112, so that the outer sidewall of the cylinder can form a seal with the inner sidewall of the housing.
In order to sufficiently transfer the liquid 300 in the cavity 112 to the upper cover 120, the protrusion 1221 occupies less space so that the cylinder 1222 connected thereto enters into the cavity 112 more, and therefore, the height of the protrusion 1221 is as short as possible. In some specific embodiments, the length of the conical projection 1221 is less than half the length (height) of the sealed housing 112.
On the piercing structure 122 of the cap 120, a passage 1224 communicating with the sealed housing 112 is provided, the passage 1224 being capable of carrying the liquid 300 in the housing 112 to the cap 120 and to other structures attached to the cap 120. Generally, the opening 1225 of the passage is located on the projection 1221 to ensure that the liquid 300 is able to transfer the liquid into the passage 1224 in a timely manner, and in one particular embodiment, the opening 1225 is located at the top end of the projection 1221, as shown in FIG. 6.
As shown in fig. 2, the present invention further includes a mixing device 800 including a cover 100 and a device body 200, wherein the cover 120 is connected to the device body 200.
As shown in fig. 6, the passage 1224 is a hollow elongated pipe, and the elongated passage 1224 is connected to the device body 200, so that the liquid 300 in the lower cap 110 can be directly transported into the device body 200 through the passage 1224; and the elongate channels 1224 also enable substantially more liquid to be delivered into the device body 200 rather than being wasted in large quantities in the channels 1224.
The cap body 100 and the device 800 of the present invention will be described in detail with reference to specific operation procedures.
The mixing device 800 is manufactured by placing a desired liquid 300 in the cavity 112 of the lower cap, and then sealing the surface 113 of the cavity with a sealing film so that the liquid 300 is sealed in the cavity 112 of the lower cap for storage.
The upper cover 120 and the lower cover 110 are screwed and fixed to form the cover body 100 through the internal threads 121 of the upper cover and the external threads 111 of the lower cover, and at the same time, a clamping strip 130 is fixed to the middle lower part of the lower cover 110, and the positions of the upper cover 120 and the lower cover 110 are defined and fixed through the clamping strip 130.
The upper cap 120 is connected to the top end thereof with a device body 200, has a separately stored solid 400 in the body 200, and includes an upper cap 210 on the body 200 to cover and seal the device body.
The cap 120 has a puncture and sealing structure 122 therein, and the end of the cylinder 1222 on the structure 122 is connected and fixed with the cap 120, or both of them can be an integral structure. The other end of the cylinder 1222 is connected to a bottleneck cylinder 1223, and the bottleneck cylinder 1223 is connected to a conical projection 1221. The length of the entire puncture and seal structure 122 is the same as the height (length) of the seal housing 112.
When the upper cap 120 and the lower cap 110 are fixed by the clamping strip 130, that is, the upper cap 120 is located at the first position of the lower cap 110, as shown in fig. 4, the puncturing structure 122 is located above the upper surface 113 of the sealed cavity, and the protrusion 1221 is located at a certain distance from the upper surface 113.
When it is desired to mix the solid and liquid, the snap strip 130 snap-fitted to the lower cap is removed, as shown in fig. 3 and 5, and then the upper cap 120 is rotated to move the upper cap 120 over the lower cap 110 toward the bottom of the lower cap 110, at the same time, the puncturing structure 122 located inside the upper cap is also moved toward the sealed cavity 112, and then the protrusion 1221 contacts the sealing membrane of the upper surface 113 of the sealed cavity. As the upper cap 120 continues to rotate, the projection 1221 presses against and pierces the sealing membrane 113 into the cavity 112, at which point the projection 1221 mates with the sealing membrane 113, still sealing the cavity 112, and the liquid 300 within the cavity is pressed through the through-hole opening 1225 into the passage 1224 on the projection as the projection 1221 encroaches into the space. As projection 1221 and associated bottleneck cylinder 1223 and cylinder 1222 enter cavity 112, piercing structure 122 substantially seals and encroaches the volume of cavity 112, allowing more and more fluid 300 within the cavity to enter channel 1224. Through the elongated channels 1224, the liquid 300 enters the device body 200 in communication with the channels, contacts the solid 400 and dissolves mixing. As shown in fig. 6.
Finally, when the upper cap 120 reaches the second position (not shown in the drawings), i.e., the bottom of the lower cap 110, the upper cap 120 stops rotating and is fixed with respect to the position of the lower cap 110. At this point, the piercing structure 122 enters the sealed housing 112 entirely, encroaching upon a substantial volume of the housing 112, thereby allowing the fluid 300 within the housing to be expelled by sufficient squeezing. Thereby, the amount of the mixed liquid in the device body 200 is sufficient, and the subsequent detection is ensured to be carried out smoothly.
Claims (9)
1. A cover body for storing and mixing liquid or solid is characterized in that the cover body comprises an upper cover and a lower cover, and the upper cover and the lower cover are movably connected; the lower cover comprises a sealed cavity; the upper cover comprises a puncture and sealing structure for puncturing and sealing the sealing cavity of the lower cover, and the cover body comprises a clamping strip for preventing the upper cover and the lower cover from moving; the clamping strip is separable from the cover body;
wherein the upper cover has a first position and a second position on the lower cover; when the upper cover is at the first position, the puncture and sealing structure is positioned at the upper surface of the sealing cavity and does not contact the upper surface; when the upper cover moves from the first position to the second position, the puncture and sealing structure contacts the upper surface of the sealing cavity, punctures and seals the surface, enters and presses the sealing cavity, and leads the liquid in the sealing cavity to flow out; when the upper cover is positioned at the second position, the puncture and sealing structure is completely positioned in the sealing cavity.
2. The cap of claim 1, wherein the puncture and seal structure comprises a conical projection.
3. The cap of claim 2, wherein the puncture and seal structure further comprises a cylindrical body attached to the end of the conical projection.
4. A cap according to claim 3, wherein the diameter of the cylinder is the same as the internal diameter of the sealed cavity.
5. A cap according to claim 4, wherein the length of the conical projection is less than half the length of the sealed cavity.
6. The cap of claim 5, wherein the puncture and seal structure further comprises a channel that communicates liquid within the seal cavity to the upper cap.
7. A cover according to claim 6, wherein the passage opening is located on a conical projection.
8. A device for storing and mixing solid and liquid, comprising a device body, characterized by further comprising a cover body according to any one of claims 1 to 7; the device main body is connected with the upper cover of the cover body and is in liquid communication.
9. The device of claim 8, wherein the passage of the piercing and sealing structure is in fluid communication with the device body.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510276416.0A CN106289933B (en) | 2015-05-27 | 2015-05-27 | Cover body and device for storing and mixing solid and liquid |
| PCT/CN2015/097374 WO2016188096A1 (en) | 2015-05-27 | 2015-12-15 | A mixing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510276416.0A CN106289933B (en) | 2015-05-27 | 2015-05-27 | Cover body and device for storing and mixing solid and liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106289933A CN106289933A (en) | 2017-01-04 |
| CN106289933B true CN106289933B (en) | 2019-12-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510276416.0A Active CN106289933B (en) | 2015-05-27 | 2015-05-27 | Cover body and device for storing and mixing solid and liquid |
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| CN (1) | CN106289933B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108535084B (en) * | 2018-04-08 | 2021-01-22 | 河南农业大学 | Liquid mixing cavity |
| CN109879339A (en) * | 2019-03-07 | 2019-06-14 | 浙江沁园水处理科技有限公司 | A kind of feeding device applied in detergent line system |
| CN110283706A (en) * | 2019-07-22 | 2019-09-27 | 安图实验仪器(郑州)有限公司 | Spiral reaction tube |
| CN113189319A (en) * | 2021-05-21 | 2021-07-30 | 云智动(杭州)科技有限公司 | Sputum sampling and detecting integrated device and using method thereof |
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| CN106289933A (en) | 2017-01-04 |
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