CN106288668B - A kind of vacuum drying system and its application - Google Patents
A kind of vacuum drying system and its application Download PDFInfo
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- CN106288668B CN106288668B CN201610724725.4A CN201610724725A CN106288668B CN 106288668 B CN106288668 B CN 106288668B CN 201610724725 A CN201610724725 A CN 201610724725A CN 106288668 B CN106288668 B CN 106288668B
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B1/00—Compression machines, plants or systems with non-reversible cycle
- F25B1/005—Compression machines, plants or systems with non-reversible cycle of the single unit type
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
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Abstract
The invention discloses a kind of vacuum drying system and its application, vacuum drying system includes drying box, solidification container, cooling component and vacuum evacuation device.The first piping connection of gas outlet of drying box is in the sealing inner cavity for solidifying container；Cooling component is used to that solid will to be frozen into the gas in container is solidified；Vacuum evacuation device by the second piping connection in the inner cavity for solidifying container, for the inner cavity of drying box to be evacuated environment.The gas formed after samples dried is drawn into solidification container through the first pipeline and is solidified into solid, the only minimal amount of gas not being cured is drawn into vacuum evacuation device by the second pipeline, the gas flow entered in vacuum evacuation device is significantly reduced in this way, its amount for forming liquid is seldom, it can be effectively reduced the probability that the environment of lubricating oil in vacuum evacuation device is destroyed, to extend the service life of motor.Furthermore the systematic difference is also disclosed, is particularly applicable in the drying of molecular biology product.
Description
Technical field
The present invention relates to technical field of drying, and in particular to a kind of vacuum drying system and its application, more specifically it relates to
A kind of application of vacuum drying system in molecular biology product drying.
Background technique
Molecular biology be from a New borderline subjects for the purpose of Molecular level study life quintessence, it with nucleic acid and
The structure of protein and other and its hereditary information and cellular informatics transmitting in effect be research object, be current
Important front edge field that is with fastest developing speed and intersecting extensively and permeate with other subject in life science.
The molecular biology research of nucleic acid is the most abundant field of current molecular biology content.Research contents includes
Nucleic acid/genome structure, the duplication of hereditary information, transcription and translation, the information reparation and mutation of nucleic acid storage, gene expression
Regulation and the development of technique for gene engineering and application etc..Wherein, multinomial research can be related to PCR operation, in a short time
DNA fragmentation is largely expanded, therefore the demand of primer is also constantly being increased.Primer synthesis at present is basic to be used
Solid phase phosphoramidite triester method, using a series of processing and purification step, is finally dried after primer synthesis, removes pure
Eluent during change, makes it dry as transparence film, in order to transport and preservation, is also beneficial to client according to practical institute
Concentration is needed to be diluted.Therefore, in the drying process of large-scale synthetic primer, for the working efficiency and work of drying equipment
Making the service life just has higher requirement.
Chinese patent literature CN101025330A discloses a kind of Minton dryer, including drying box, puts down in the horizontal direction
There are vacuum pump in the several layers heating plate that is arranged in drying box of row, the gas outlet at the top of drying box by piping connection, the vacuum
Pump is made of lobe pump and sliding vane rotary pump, and cooling recirculation system is arranged between lobe pump and sliding vane rotary pump.The cooling recirculation system
Including condensing catcher, with the sequentially connected compressor of condensation catcher, heat exchanger, air cooler, fluid reservoir and subcooler, supercooling
Device is reconnected in condensation catcher, to form circulation loop.
The Minton dryer of above structure, before dry sample or in drying process, the gas in drying box is through pipe
Road is first pumped into condensation catcher by lobe pump, and under the action of cooling system, gas is cooled into condensation catcher
Liquid, and this solution is collected in fluid reservoir, the gas not being condensed pumps to the external world through sliding vane rotary pump again.
But the Minton dryer of this structure, the gas in drying box drain into itself meeting to the cold in lobe pump by the road
Liquid is formed, and can be remained in lobe pump, as the continuous accumulation of solution will destroy the lubricating oil environment of motor in lobe pump,
So that the gear of motor can not normal rotation, ultimately cause the damage of motor.Meanwhile the cooling system of above structure, it will be pumped into
It is liquid to the gas cooling in condensation catcher, the gas not being condensed will enter sliding vane rotary pump with more solution
It is interior, equally the motor of sliding vane rotary pump is damaged, needs frequently to repair or replace motor, leads to the maintenance cost of drying device
Height, while reducing the working efficiency of drying device.
Summary of the invention
Therefore, technical problem to be solved by the present invention lies in the motor damages for how avoiding Minton dryer, reduce
Maintenance cost, while improving the working efficiency of Minton dryer.
For this purpose, the present invention provides a kind of vacuum drying system, including
Drying box is at least one, has inner cavity, gas outlet in communication with the inner cavity, and be mounted on the outlet
The first pipeline on mouth, the inner cavity are equipped with the storage area for placing sample；
Solidify container, have a Packed inner cavity, the outlet side sealing of first pipeline, which is protruded into, described solidifies the interior of container
In chamber；
Cool down component, described solidify the vapor in container for will enter and is frozen into ice；
Vacuum evacuation device, by the second piping connection in the inner cavity for solidifying container, and the air inlet of second pipeline
End sealing is protruded into the inner cavity for solidifying container, is used for through second pipeline, solidification container and first pipeline, will
The inner cavity of the drying box is evacuated environment.
Preferably, the container that solidifies includes the first cylinder that top has the first opening, and is sealingly disposed in described the
The lid of one opening；
Lid described in the equal hermetically passing of inlet end of the outlet side and the second pipeline of first pipeline and protrude into described
In one cylinder.
It is further preferred that the outlet side of first pipeline is located at second pipeline in first cylinder
The lower section of inlet end.And/or
The container that solidifies further includes the second cylinder with the second opening, and first cylinder is embedding from second opening
Enter in second cylinder, first opening and described second is open towards identical, the inner wall of second cylinder and institute
It states and forms preset clearance between the outside wall surface of the first cylinder, the freezing point that the preset clearance is used to place freezing point lower than water
Buffer solution.
Further preferably: the first intracorporal length is protruded into the outlet side of first pipeline, is greater than described the
The inlet end of two pipelines protrudes into the length of first cylinder.
More preferably preferably, the container that solidifies further includes the hollow casing that top has third opening, second cylinder
It is embedded in the hollow casing through third opening；The inner wall of the outside wall surface of second cylinder and the hollow casing it
Between form installation space, the cooling component is mounted in the installation space.
Preferably, the cooling component includes the condenser pipe being wrapped on the outer surface of second cylinder, and described cold
The condenser and evaporator that the both ends of solidifying pipe are separately connected, are arranged in the compressor between the condenser and the evaporator,
And the blower on the evaporator is set, if opening up what the confession blower was in communication with the outside on the wall surface of the hollow casing
Dry ventilation hole.
It is further preferred that above-mentioned vacuum drying system further includes throttling set, the throttling set is arranged described
On second pipeline, and be located at the outside for solidify container, the throttling set for control first inner barrel with outside
Boundary's connection or truncation.
Preferably, the throttling set includes
Third pipeline, there are two open ends for tool；
Tee pipe coupling, one end are connected on second pipeline, and in addition removably sealing is plugged on institute respectively at both ends
It states in two open ends of third pipeline；And
Valve is two, is separately positioned on the both ends far from second pipeline of the tee pipe coupling.
It is further preferred that first pipeline or the second pipeline include main line, and it is arranged in described main line one end
On L-type rigid pipe, the vertical portion of the L-type rigid pipe protrudes into first cylinder, and horizontal position is in first cylinder
Outside.
More preferably preferably, the first of first cylinder, which is open, has the outwardly extending first circumferential outer, and described second
Second opening of cylinder has outwardly extending second week to outer；The second week overlaps to outer and is fixed on the sky
On the top surface of heart shell, the described first circumferential outer is overlapped on the second week on outer.
Preferably, the drying box is at least two, further includes at least two branch pipes；
One end of the branch pipe is mounted on correspondingly on the gas outlet of the drying box, and the other end is all connected to described
First pipeline, and with first pipeline connection.
The present invention also provides application of the above-mentioned vacuum drying system in molecular biology product drying.
Technical solution provided by the invention, has the advantages that
1. vacuum drying system provided by the invention, including at least one drying box, solidification container, cooling component and pumping are true
Empty device.Drying box has inner cavity, gas outlet in communication with the inner cavity, and the first pipe being mounted on the gas outlet
Road, the inner cavity are equipped with the storage area for placing sample；Solidify container and has Packed inner cavity, the outlet of first pipeline
End sealing is protruded into the inner cavity for solidifying container；Cooling component described solidify the vapor in container and is frozen into for that will enter
Ice；Vacuum evacuation device passes through the second piping connection in the inner cavity for solidifying container, and the inlet end of second pipeline seals
It protrudes into the inner cavity for solidifying container, for that described will do through second pipeline, solidification container and first pipeline
The inner cavity of dry case is evacuated environment.
The vacuum drying system of this structure, setting solidification container and cooling component between drying box and vacuum evacuation device,
When being if desired dried in vacuo to sample, the gas in drying box is taken out under the action of vacuum evacuation device through the first pipeline
Enter to solidify in container, cooling component by the temperature for solidifying container be down to gas can cured temperature, even lower temperature, into
Enter the gas solidified in container and directly form solid, or be initially formed liquid and be frozen into solid again, is collected in solidification container,
In this way after solidifying container, the only minimal amount of gas not being cured just passes through the second pipeline and is drawn into vacuum means
In setting, the gas entered in vacuum evacuation device is significantly reduced, the amount that gas forms liquid is also seldom, reduces vacuum evacuation device
The probability that the environment of interior lubricating oil is destroyed reduces motor so that the motor in vacuum evacuation device can be operated normally
The cost of replacement or maintenance, extends the service life of motor.
2. vacuum drying system provided by the invention, solidifying container includes the first cylinder that top has the first opening, and
It is sealingly disposed in the lid of first opening；The equal hermetically passing lid of the inlet end of the outlet side of first pipeline and the second pipeline
Body and protrude into first cylinder.Vessel Design will be solidified into separate structure, the amount to be collected into solid in the first cylinder reaches
It when to predetermined amount, needs to take away first intracorporal solid, lid need to only be opened at this time, directly take the first cylinder away i.e.
Can, so that manual cleaning is more convenient.The first taken away cylinder can also be directly replaced with identical cylinder simultaneously, convenient for dry
The continuity of dry process.
3. vacuum drying system provided by the invention, solidifying container further includes having second the second cylinder being open, and first
Cylinder is embedded in second cylinder from second opening, the first opening and the second opening towards identical, the second cylinder it is interior
Preset clearance is formed between wall surface and the outside wall surface of the first cylinder, the preset clearance is used to place the solidification that freezing point is lower than water
The buffer solution of point, the interior buffer solution placed of preset clearance.
Since the freezing point of buffer solution is lower than the freezing point of water, when first intracorporal gas formation ice or water-setting are solid
When at ice, buffer solution will not be frozen into solid, be still liquid, so that still in separating shape between the first cylinder and the second cylinder
State only need to open lid when needing to take out the first cylinder collection solid, and the first cylinder is whole from the inner cavity of the second cylinder
Taking-up, convenient for taking out the first cylinder at any time.
4. vacuum drying system provided by the invention further includes throttling set, throttling set is arranged in second pipeline
On, and be located at the outside for solidify container, the throttling set be used for control first inner barrel be in communication with the outside or
Truncation.
In dry specimen, if the solid needs of first intracorporal collection are taken away in time, it is necessary to lid is opened,
But since the inner cavity of the first cylinder is in negative pressure state, people can not normally open lid, by opening this throttling set, so that the
The inner cavity of one cylinder is in communication with the outside, and forms atmospheric pressure environment, so that people is easy to remove lid from the first cylinder, takes out the
One cylinder simultaneously takes first intracorporal solid away, and the first empty cylinder is mounted in the second cylinder again later, is closed again at this time
Close throttling set, under the action of vacuum evacuation device, the inner cavity of the first cylinder gradually return to again before negative pressure state, after
Continue subsequent drying process.
5. the present invention also provides application of the above-mentioned vacuum drying system in molecular biology product drying.It will be above-mentioned
Vacuum drying system is applied in molecular biology product drying, so that the gas formed during molecular biology product drying
It is introduced into solidification container, most gas forms solid and is collected in solidification container, and only a small amount of gas is not consolidated
Change, and entered in vacuum evacuation device through the second pipeline, then arrange outwardly, so that the motor of vacuum evacuation device is not easy to be damaged
It is bad, the cost of motor replacement or maintenance is reduced, the service life of motor is extended, improves drying efficiency.In addition, molecular biology produces
Organic substance containing part in the dry gas formed of product, this organic substance are collected in solidification container by solidification, only
Outwardly air is just arranged on a small quantity, reduce the pollution to environment.The molecular biology product includes but is not limited to: plasmid,
Primer, RNA, DNA, antibody, glycoprotein or nucleoprotein.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is the structural schematic diagram of vacuum drying system provided by the embodiment of the present invention；
Description of symbols: 1- drying box；The first cylinder of 21-；The circumferential outer 211- first；22- lid；23- is hollow outer
Shell；241- condenser pipe；242- compressor；243- evaporator；244- blower；245- condenser；The second cylinder of 25-；251- second
Circumferential outer；3- vacuum evacuation device；The first pipeline of 4-；The second pipeline of 5-；6- third pipeline；7- tee pipe coupling；8- valve.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" be based on the orientation or positional relationship shown in the drawings, merely to
Convenient for description the present invention and simplify description, rather than the device or element of indication or suggestion meaning must have a particular orientation,
It is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.
As long as in addition, the non-structure each other of technical characteristic involved in invention described below different embodiments
It can be combined with each other at conflict.
Embodiment 1
The present embodiment provides a kind of vacuum drying systems, as shown in Figure 1, including
One drying box 1, with inner cavity, the gas outlet being connected to inner cavity, and the first pipeline being mounted on gas outlet
4, inner cavity is equipped with the storage area for placing sample；
Solidify container, have Packed inner cavity, the outlet side sealing of the first pipeline 4 is protruded into the inner cavity for solidifying container；
Cool down component, solidifies the gas in container for will enter and is frozen into ice；
Vacuum evacuation device 3 is connected to the inner cavity for solidifying container, and the inlet end sealing of the second pipeline 5 by the second pipeline 5
It protrudes into the inner cavity for solidifying container, for through the second pipeline 5, solidification container and the first pipeline 4, the inner cavity of drying box 1 to be taken out
At vacuum environment.
The vacuum drying system of this structure, setting solidification container and cooling group between drying box 1 and vacuum evacuation device 3
Part, when being if desired dried in vacuo to sample, the gas in drying box 1 is under the action of vacuum evacuation device 3, through the first pipeline
4 be drawn into solidification container in, cooling component by the temperature for solidifying container be down to gas can cured temperature, even lower temperature
Degree directly forms solid into the gas in fixed container, or is initially formed liquid and is frozen into solid again, is collected in solidification and holds
In device, in this way after solidifying container, the only minimal amount of gas not being cured just passes through the second pipeline 5 and is drawn into pumping
In vacuum plant 3, the gas entered in vacuum evacuation device 3 is significantly reduced, the amount that gas forms liquid is also seldom, reduces and takes out
The probability that the environment of lubricating oil is destroyed in vacuum plant 3, so that the motor in vacuum evacuation device 2 can be transported normally
Turn, reduces the cost of motor replacement or maintenance, extend the service life of motor.
As preferred embodiment, the above-mentioned container that solidifies includes the first cylinder 21 that top has the first opening, and
It is sealingly disposed in the lid 22 of the first opening；The equal hermetically passing lid of the inlet end of the outlet side of first pipeline 4 and the second pipeline 5
Body 22 and protrude into the first cylinder 21.
In this embodiment, by solidification Vessel Design at separate structure, the amount to be collected into solid in the first cylinder 21 reaches
It when to predetermined amount, needs to take away the solid in the first cylinder 21, lid 22 need to only be opened at this time, directly take the first cylinder away
21, so that manual cleaning is more convenient.The first taken away cylinder 21 can also be directly replaced with identical cylinder simultaneously,
Convenient for the continuity of drying process.
Preferably, in the first cylinder 21, the outlet side of the first pipeline 4 is located at the lower section of the inlet end of the second pipeline 5, makes
It obtains the gas in the first cylinder 21 and forms the short mode out of progress, prevent the gas entered in the first cylinder 21 uncured with regard to directly
It connects and is drained into vacuum evacuation device 3 through the second pipeline 5.
It is further preferred that as described in Figure 1, the length in the first cylinder 21 is protruded into the outlet side of the first pipeline 4, it is greater than the
The inlet end of two pipelines 5 protrudes into the length of the first cylinder 21.More preferably, the inlet end and first of the second pipeline 5 in the horizontal direction
The outlet side of pipeline 4 is in be staggeredly arranged.
As further preferred embodiment, solidifying container further includes having second the second cylinder 25 being open, and first
Cylinder 21 is out of second opening the second cylinder 25 of insertion, and the first opening and the second opening are towards identical, the inner wall of the second cylinder 25
Form preset clearance between face and the outside wall surface of the first cylinder 21, preset clearance is used to placing freezing point of the freezing point lower than water
Buffer solution.
In this embodiment, buffer solution is placed in the preset clearance between the first cylinder 21 and the second cylinder 25, due to
The freezing point of buffer solution is lower than the freezing point of water, when the gas in the first cylinder 21 forms ice or water is frozen into ice, delays
Solid will not be frozen by rushing solution, be still liquid, so that still in discrete state between the first cylinder 21 and the second cylinder 25,
When needing to take out the solid collected in the first cylinder 21, lid 22 only need to be opened, the first cylinder 21 is whole from the second cylinder 25
Inner cavity in take out, further take out the solid in the first cylinder 21, prevent the first cylinder 21 from freezing with the second cylinder 25
Phenomenon can not in time take out the first cylinder 21 out of second cylinder 25.In addition, the solid that gas is formed by curing, is not limited only to
Ice, during samples dried, into the gas in the first cylinder 21 possible with the sample of certain ingredients, the gas of this part
Body solidification temperature may become lower, need that the lower buffer solution of freezing point is added in preset clearance at this time, to guarantee
First cylinder 21 is in isolated state with the second cylinder 25.When being ice for solid, buffer solution is preferably alcohol.
As preferred embodiment, solidifying container further includes the hollow casing 23 that top has third opening, and second
Body 25 is open in insertion hollow casing 23 through third；It is formed between the outside wall surface of second cylinder 25 and the inner wall of hollow casing 23
Installation space, cooling component are installed in this installation space, so that solidifying the compact-sized of container, occupied space is small.
As the preferred of cooling component, as shown in Figure 1, cooling component includes being wrapped on the outer surface of the second cylinder 25
Condenser pipe 241, the condenser 245 and evaporator 243 being separately connected with the both ends of condenser pipe 241, setting is in condenser 245 and steams
The compressor 242 between device 243, and the blower 244 being arranged on evaporator 243 are sent out, is opened up on the wall surface of hollow casing 23
Several ventilation holes being in communication with the outside for blower 244.
The cooling component of this structure needs to set in condenser pipe 241 when to the second cylinder 25 and the cooling of the first cylinder 21
Condensing agent is set, condensing agent forms the liquid condensation agent of high temperature and pressure under the effect of compressor 242, and the condensing agent of liquid is in condenser
The liquid condensation agent of low temperature is formed in 245, the heat transfer discharged is to the space between hollow casing 23 and the second cylinder 25
It is interior, then be discharged through air port；The condensing agent of low temperature, which enters, to be wrapped in the condenser pipe 241 in 25 outside wall surface of the second cylinder, low temperature
Condensing agent constantly reduces the temperature of the second cylinder 25 by condenser pipe 241, and then reduces the temperature of the first cylinder 21, heat exchange
Condensing agent afterwards enters in evaporator 243, forms gaseous condensing agent, and gaseous condensing agent enters back into compressor 242 later,
The condensation process started the cycle over.In evaporator 243, when the condensing agent of liquid forms gaseous condensing agent, required heat
It is pumped into the air in evaporator 243 from the external world by blower 244 to provide, discharge of the air again through blower 244 after heat exchange.
As deformation, above-mentioned cooling component can also be other condensations or cooling device in the prior art, need to only set
It sets in 25 outer wall surrounding of the second cylinder, low temperature is reduced to the temperature of the second cylinder 25 and the first cylinder 21, can will enter the
Gas solidification in one cylinder 21, but the buffering that cannot be below in the preset clearance between the first cylinder 21 and the second cylinder 25 is molten
The freezing point of liquid.
As preferred embodiment, insulating layer is wrapped up in 241 outside wall surface of condenser pipe, condenser pipe 241 is separated with the external world,
Condenser pipe 241 is enabled to keep low temperature for a long time, to cool down to the second cylinder 25 and the first cylinder 21.
As preferred embodiment, as shown in Figure 1, the first opening of the first cylinder 21 has outwardly extending first week
To outer 211, the second opening of the second cylinder 25 has outwardly extending second week to outer 251；Second week is to outer 251
It overlaps and is fixed on the top surface of hollow casing 23, the first circumferential outer 211 is overlapped on second week on outer 251.
It is further preferred that the top of the first circumferential outer 211 opens up first annular groove, the bottom surface tool of lid 22
There is the second annular groove opposite with first annular groove, second annular groove and first annular groove form installation sealing element
Space, such as O-ring seal are clamped in this space, so that lid 22 is connected and sealed with the first cylinder 21；Or it is existing
Other in technology are tightly connected mode.
More preferably preferably, second week forms annular protrusion, the inner wall of annular protrusion to the edge of outer 251 is also prominent
Gap is formed between face and the outside wall surface of the first circumferential outer 211.As deformation, annular protrusion can be not provided with.
It is further preferred that handle is arranged on the side wall at the top of the first cylinder 21, when taking out the from the second cylinder 25
When one cylinder 21, manpower has an impetus, convenient for taking out the first cylinder 21.
As solidification distortion of vessel, the solidification container of above structure can also be not provided with the second cylinder 25, only setting the
One cylinder 21, cooling component are arranged in the space between the first cylinder 21 and hollow casing 23；Or sky can also be not provided with
Heart shell 23, is only arranged the first cylinder 21, and cooling component is wound around the outer wall surrounding of the first cylinder 21, plays cooling effect i.e.
It can.
In addition, the above-mentioned shape for solidifying container can not be tubular, it can be the box body of other shapes in the prior art,
Or container, concrete shape without limitation, and have Packed inner cavity, convenient for forming required negative pressure ring in container solidifying
Border.
As further preferred embodiment, above-mentioned vacuum drying system further includes throttling set, and throttling set is set
It sets on the second pipeline 5, and is located at the outside for solidifying container, throttling set is in communication with the outside inside the first cylinder 21 for controlling
Or truncation.In dry specimen, if the solid needs of the collection in the first cylinder 21 are taken away in time, it is necessary to open lid
22, but since the inner cavity of the first cylinder 21 is in negative pressure state, people can not normally open lid 22, be filled by opening this throttling
It sets, so that the inner cavity of the first cylinder 21 is in communication with the outside, forms atmospheric pressure environment, so that people is easy to lid 22 from the first cylinder
It is removed on 21, take out the first cylinder 21 and takes the solid in the first cylinder 21 away, the first empty cylinder 21 is installed again later
In the second cylinder 25, turn off throttling set at this time, under the action of vacuum evacuation device 3, the inner cavity of the first cylinder 21 again by
Negative pressure state before gradually being restored to continues subsequent drying process.
As the preferred of throttling set, as shown in Figure 1, throttling set includes third pipeline 6, tee pipe coupling 7 and two
Valve 8, there are two open ends for the tool of third pipeline 6；One end of tee pipe coupling 7 is connected on the second pipeline 5, in addition both ends point
Removably sealing is not plugged in two open ends of third pipeline 6；Two valves 8 are separately positioned on tee pipe coupling 7
Far from the second pipeline 5 both ends on.
It, only need to be by the one of third pipeline 6 when needing the inner cavity by the first cylinder 21 to be in communication with the outside in this embodiment
Open end is pulled from tee pipe coupling 7, as soon as open a valve 8 or two valves 8, the inner cavity energy of the first cylinder 21
Enough connections with the external world；When needing the inner cavity of the first cylinder 21 and extraneous truncation, the valve 8 for the front opening that need to only close,
The open end pulled before third pipeline 6 is plugged on again on the corresponding one end of three-way connection.In addition, in the first cylinder
When 21 inside is in subnormal ambient, two valves 8 prevent the gas in the first cylinder 21 to be flowed into all in closed state
On three pipelines 6, gap existing for two open ends and tee pipe coupling 7 through third pipeline 6 drains into the external world, it is difficult at first
Subnormal ambient needed for being formed in body 21.
It can also be valve in the prior art, but such valve allows for realizing as the deformation of throttling set
The performance of high pressure sealing.
As further preferred embodiment, the first pipeline 4 or the second pipeline 5 include main line, and setting is being responsible for
L-type rigid pipe on the one end of road, the vertical portion of L-type rigid pipe are protruded into the first cylinder 21, and horizontal position is in outside the first cylinder 21.
The L-type rigid pipe of setting can convenient for the inlet end of the outlet side of the first pipeline 4 or the second pipeline 5 to be threaded through on lid 22
Bear bigger external forces.
Preferably, above-mentioned vacuum evacuation device 3 is vacuum pump, or in the prior art using other motor-driven pumpings
Vacuum plant.
Embodiment 2
A kind of vacuum drying system provided in this embodiment, difference from Example 1 are: drying box 1 is two, also
Including two branch pipes；One end of two branch pipes is separately mounted on the gas outlet of two drying boxes 1, and the other end of two branch pipes is equal
It is connected to the first pipeline 4, and is connected to the first pipeline 4.
The gas of the gas outlet discharge of two drying boxes 1 is all summarised in by this embodiment by corresponding branch pipe
In first pipeline 4, then cured container and the second pipeline 5, it is arrived in vacuum evacuation device 3 later, so that two drying boxes, 1 need one
A vacuum evacuation device 3 drives, and it is not necessary that a vacuum evacuation device 3 is separately provided to each drying box 1, reduces the setting of vacuum plant
Number, and drying box 1 can be arranged indoors, vacuum evacuation device 3 is arranged in outdoor.
As deformation, the number of above-mentioned drying box 1 can also be three, four, five, six etc., accordingly, branch pipe
Number be also three, four, five, six etc.；Multiple branch pipes are connected to the first pipeline 4, need to be only arranged one and be taken out very
Empty device 3, so that entire vacuum drying system is compact-sized, occupied area is small；And it can will be several
A drying box 1 is placed indoors, and a vacuum evacuation device 3 is placed on outdoor, even if thering is liquid to flow out in vacuum evacuation device 3,
Interior will not be drained into.
Embodiment 3
The present embodiment provides any vacuum drying systems recorded in above-described embodiment 1 or embodiment 2 in molecular biology
Application in product drying.
Vacuum drying system in embodiment 1 or embodiment 2 is applied in molecular biology product drying, so that molecule
Biology needs the gas formed during product drying to be introduced into solidification container, and most gas forms solid and is collected in admittedly
To change in container, only a small amount of gas is uncured, and enters in vacuum evacuation device 3 through the second pipeline 5, then arrange outwardly,
So that the motor of vacuum evacuation device 3 is not easy to be damaged, the cost of motor replacement or maintenance is reduced, extend motor uses the longevity
Life.In addition, the organic substance containing part in the gas that molecular biology product drying is formed, this organic substance is by solidification quilt
It collects in solidification container, as long as just arranging outwardly air on a small quantity, reduces the pollution to environment.
Above-mentioned molecular biology product mainly includes plasmid, primer, RNA, DNA, antibody, glycoprotein or nucleoprotein,
Or other molecular biology products in the prior art.
In order to better understand, the vacuum drying system in embodiment 1 or embodiment 2 is in molecular biology product drying
Application, now illustrated with the drying of synthetic primer, synthetic primer to be dried is solution state, and the moisture that contains mainly comes
The final eluent in purification process, eluent are usually the level-one water of laboratory purification device preparation, are also possible to other
Eluent used in molecular biology experiment.Drying box 1, solidification container, cooling component setting in vacuum drying system exist
Interior, vacuum evacuation device 3 are arranged in outdoor.
Specific drying process includes the following steps:
The synthetic primer collected after will be purified is collected in EP pipe, and the synthetic primer liquor capacity in EP pipe is no more than
150μL；
EP pipe equipped with synthetic primer is placed on EP pipe support, then EP pipe support is placed on to the storage area in drying box
On, drying temperature is set as 50-60 DEG C, drying time is set as 2-3 hours；
Vacuum evacuation device 3 and cooling component are opened, to constantly vacuumizing in drying box 1, forms required subnormal ambient, directly
Dry completely to synthetic primer, the product after drying is transparent membrane, and client's use can be sent to directly as finished product.
In this drying process, since drying box 1, solidification container, cooling component are in interior, vacuum evacuation device 3 is in room
Outside, the gas by primer after dry is largely collected in solidification container, and only a small amount of evacuated device of gas is arranged outwardly,
So that in room air will not residual organic matter, while multiple drying boxes being set side by side can also be set indoors, after dry
Gas be all aggregated into solidification container in, improve the drying efficiency of synthetic primer.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (9)
1. a kind of vacuum drying system, which is characterized in that including
Drying box (1) is at least one, has inner cavity, gas outlet in communication with the inner cavity, and be mounted on the gas outlet
On the first pipeline (4), the inner cavity is equipped with storage area for placing sample；
Solidify container comprising top has the first cylinder (21) of the first opening, and is sealingly disposed in first opening
Lid (22)；Sealing inner cavity is surrounded between the lid (22) and first cylinder (21)；
Cool down component, for the vapor in the sealing inner cavity for entering first cylinder to be frozen into ice；
Vacuum evacuation device (3) is connected to the sealing inner cavity of first cylinder, and first pipeline by the second pipeline (5)
(4) lid (22) described in the equal hermetically passing of inlet end of outlet side and the second pipeline (5) and protrude into first cylinder (21)
Sealing inner cavity in；
The vacuum evacuation device (3) is used for through second pipeline (5), the first cylinder and first pipeline (4), will be described
The inner cavity of drying box (1) is evacuated environment.
2. vacuum drying system according to claim 1, it is characterised in that:
In first cylinder (21), the outlet side of first pipeline (4) is located at the inlet end of second pipeline (5)
Lower section；And/or
The container that solidifies further includes the second cylinder (25) with the second opening, and first cylinder (21) is from described second
It is open and is embedded in second cylinder (25), first opening and described second is open towards identical, second cylinder
(25) preset clearance is formed between the outside wall surface of inner wall and first cylinder (21), the preset clearance is solidifying for placing
Buffer solution of the solid point lower than the freezing point of water.
3. vacuum drying system according to claim 2, it is characterised in that: the solidification container further includes that top has the
The hollow casing (23) of three openings, second cylinder (25) are embedded in the hollow casing (23) through third opening；Institute
It states and forms installation space, the cooling component between the outside wall surface of the second cylinder (25) and the inner wall of the hollow casing (23)
It is mounted in the installation space.
4. vacuum drying system according to claim 3, it is characterised in that: the cooling component includes being wrapped in described the
Condenser pipe (241) on the outer surface of two cylinders (25), the condenser being separately connected with the both ends of the condenser pipe (241)
(245) and evaporator (243) compressor (242), being arranged between the condenser (245) and the evaporator (243), with
And blower (244) on the evaporator (243) is set, it is opened up on the wall surface of the hollow casing (23) for the blower
(244) several ventilation holes being in communication with the outside.
5. vacuum drying system described in any one of -4 according to claim 1, it is characterised in that: it further include throttling set, institute
It states throttling set to be arranged on second pipeline (5), and is located at the outside for solidifying container, the throttling set is for controlling
It makes and is in communication with the outside or is truncated inside first cylinder (21).
6. vacuum drying system according to claim 5, it is characterised in that: the throttling set includes
Third pipeline (6), there are two open ends for tool；
Tee pipe coupling (7), one end are connected on second pipeline (5), and in addition removably sealing is plugged on respectively at both ends
In two open ends of the third pipeline (6)；And
Valve (8) is two, is separately positioned on the both ends far from second pipeline (5) of the tee pipe coupling (7).
7. vacuum drying system according to claim 3 or 4, it is characterised in that: the first of first cylinder (21) opens
Mouth has the outwardly extending first circumferential outer (211), and the second opening of second cylinder (25) has outwardly extending
Second week is to outer (251)；The second week overlaps to outer (251) and is fixed on the top surface of the hollow casing (23)
On, the described first circumferential outer (211) is overlapped on the second week on outer (251).
8. vacuum drying system described in any one of -4 according to claim 1, it is characterised in that: the drying box (1) is extremely
It is two few, it further include at least two branch pipes；
One end of the branch pipe is mounted on correspondingly on the gas outlet of the drying box (1), and the other end is all connected to described
First pipeline (4), and be connected to first pipeline (4).
9. such as application of the described in any item vacuum drying systems of claim 1-8 in molecular biology product drying.
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| CN201610724725.4A CN106288668B (en) | 2016-08-25 | 2016-08-25 | A kind of vacuum drying system and its application |
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| CN201610724725.4A CN106288668B (en) | 2016-08-25 | 2016-08-25 | A kind of vacuum drying system and its application |
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| CN106288668B true CN106288668B (en) | 2019-03-29 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103141559A (en) * | 2013-03-27 | 2013-06-12 | 山东鼎力枣业食品集团有限公司 | Processing method for vacuum frozen dried puffed fresh golden silk jujube |
| CN203264320U (en) * | 2013-04-18 | 2013-11-06 | 漯河美迪康生物科技有限公司 | Vacuum reduced-pressure distillation device |
| CN105077539A (en) * | 2015-08-03 | 2015-11-25 | 天津市傲绿农副产品集团股份有限公司 | Energy-saving type fruit and vegetable vacuum refrigeration drying system |
| CN204923696U (en) * | 2015-08-28 | 2015-12-30 | 合肥国肽生物科技有限公司 | Be used for quick freeze -drying device of polypeptide |
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2016
- 2016-08-25 CN CN201610724725.4A patent/CN106288668B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103141559A (en) * | 2013-03-27 | 2013-06-12 | 山东鼎力枣业食品集团有限公司 | Processing method for vacuum frozen dried puffed fresh golden silk jujube |
| CN203264320U (en) * | 2013-04-18 | 2013-11-06 | 漯河美迪康生物科技有限公司 | Vacuum reduced-pressure distillation device |
| CN105077539A (en) * | 2015-08-03 | 2015-11-25 | 天津市傲绿农副产品集团股份有限公司 | Energy-saving type fruit and vegetable vacuum refrigeration drying system |
| CN204923696U (en) * | 2015-08-28 | 2015-12-30 | 合肥国肽生物科技有限公司 | Be used for quick freeze -drying device of polypeptide |
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