CN106280977A - A kind of silicone rubber antimicrobial coating - Google Patents
A kind of silicone rubber antimicrobial coating Download PDFInfo
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- CN106280977A CN106280977A CN201510262994.9A CN201510262994A CN106280977A CN 106280977 A CN106280977 A CN 106280977A CN 201510262994 A CN201510262994 A CN 201510262994A CN 106280977 A CN106280977 A CN 106280977A
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- chlorhexidine
- coating
- silicone rubber
- mdx4
- antimicrobial coating
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Abstract
The present invention relates to a kind of silicone rubber antimicrobial coating, coating is prepared via a method which: chlorhexidine series products is dissolved in ethyl acetate by A.；B. organic silicon solvent Q7 2650 is used to be diluted by silicone adhesives MDX4 4210；C. by after the chlorhexidine concentration mixing on request of both the above component, add MDX4 4210 catalyst, and stir.The coating of the present invention can be coated on silicone rubber kinds medical apparatus surface, plays and original apparatus is increased antibacterium, antifungal and the function of other microorganisms of curing the disease.Chlorhexidine class antibiotic substance is combined by the present invention with hydrophobic silica gel material, reaches to promote the purpose of existing silica type medical apparatus and instruments additional function.
Description
Technical field
The present invention relates to a kind of silicone rubber coating, a kind of silicone rubber coating containing antibacterial.
Background technology
At present, plastics and rubber polymer product are widely used in every field, use especially extensive at medical field, and curable product is in addition to the material such as metal and glass, and many is that polymeric material proportion is the highest.Along with the development of Medical Technology, interventional therapy conduit is widely applied in clinical treatment.Many needs short-term or the medical apparatus and instruments contacted for a long time with tissue, as conduit, seal wire etc. can bring pathogenic microorganism into when inserting or pull out and stop in human body and breed hypertrophy generation infection, thus it is likely to result in the infringement to tissue and then causes the untoward reaction such as inflammation.Therefore, for reducing operation risk, alleviate patient's misery, need preoperative or postoperative oral antibiotic.What this also will cause antibiotic excessively uses the clinical problems such as the resistance brought.Due to unique hydrophobic property of Silica Surface, it is difficult to directly antimicrobial component is directly involved Silica Surface.
Disclosed in December in 2010 29 days, the PCT Patent of Publication No. WO 2010/151682A2 provides a kind of method allowing silicone material obtain slow release chlorhexidine, its method is to be immersed in certain density chlorhexidine by silicone material, uses after soaking certain time.The silicone material that this method obtains, one layer of chlorhexidine is had in surface attachment, wherein combined by suction type between silicone material and chlorhexidine, adhesion is the most weak, and during release, rate of release starts quickly, reduce the most rapidly, when causing silicone material to use, in surrounding medium, the concentration of chlorhexidine starts the highest, but quickly reduces, and slow release effect is very bad.And under fluid environment, medicine is the most easily dissolved, cause the peak of release to occur suddenly reducing too early and at once.During preparing antibacterial polymer by immersion process, immersion for up to 24 even 48 hours, use and inconvenient.And, this antibacterial polymer prepared by the way of soaking adsorption antibacterial agent, the apparatus such as packed and transported and conduit inserts internal when, the antibacterial on surface is easy to peel off.
Summary of the invention
It is an object of the invention to provide between a kind of chlorhexidine and silicone rubber that adhesion is strong, do not allow caducous silicone rubber antimicrobial coating.
The silicone rubber antimicrobial coating of the present invention is prepared via a method which:
A. chlorhexidine or chlorhexidine derivant are dissolved in solvent；
B. diluent Q7-2650 is used to be diluted by MDX4-4210 bonding agent.
C. by gained liquid in step A and gained liquid mixing in step B, after adding MDX4-4210 catalyst, mix homogeneously.
Solvent ethyl acetate described in above-mentioned steps A, it is also possible to select other that siloxanes and chlorhexidine are dissolved compatible good solvent.
Chlorhexidine derivant described in above-mentioned steps A can be chlorhexidine gluconate or chlorhexidine hydrochloride, it is also possible to is that other have the chlorhexidine derivant of antibacterial functions.
In above-mentioned steps B, diluent Q7-2650 is (10:1～1:1), preferably 4:1 with the mixed proportion scope of MDX4-4210 bonding agent, and can be adjusted according to the thickness requirement of final coating.
In above-mentioned steps A, the concentration of chlorhexidine can be adjusted according to the needs of final antibacterial situation；In step A described in step C and step B, the mixed proportion of two kinds of liquid can also be adjusted according to the needs of final antibacterial situation.
Coating coating surface fastness test prepared by this patent, result is one-level, without visible coating shedding.
Method of testing is the test of TQC adhesive force cross-cut.
In the present invention, diluent Q7-2650 refers to the medical organic silicon solvent that Dow Corning Corporation (Dow Corning) produces, MDX4-4210 refers to the silica-based bonding agent of medical grade double-component that Dow Corning Corporation produces, it is divided into bonding agent and two independent packaging components of catalyst, is called MDX4-4210 bonding agent and MDX4-4210 catalyst.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment
1
Silicone rubber antimicrobial coating is prepared via a method which:
A. chlorhexidine is dissolved in ethyl acetate, concentration 20 mg/ml；
B. take 40ml diluent Q7-2650 and 10ml MDX4-4210 bonding agent, by the two mix homogeneously, add the chlorhexidine ethyl acetate solution that concentration is 20mg/ml of preparation, mix homogeneously in 8ml step A；
C. press the volume ratio of MDX4-4210 bonding agent and MDX4-4210 catalyst 50:1, in the liquid that step B finally obtains, add MDX4-4210 silica-gel catalyst 0.2ml, and mix homogeneously；
C. a certain amount of chlorhexidine is added in the mixture of silica gel bonding agent, and stir, silicone rubber antimicrobial coating can be obtained.
After silica gel tube one end closure, it is infiltrated in the silicone rubber antimicrobial coating prepared according to above-mentioned steps, takes out after keeping 10 seconds, at room temperature loft dried 16 hours, treating that bonding agent solidification is dried, room temperature in vacuo is dried 4 hours, and coating can be fixed on silica gel tube surface.Above-mentioned silica gel tube is the NALGENE50 silica gel tube of NALGENE company, product designation 8060-0030.
Coating is fixed on the effect of Silica Surface tests through coating surface fastness, and result is one-level, without visible coating shedding.Test instrunment and method: TQC adhesive force cross-cut test (TQC Cross Cut Adhesion
Test).
In above-mentioned steps A, the concentration of the ethyl acetate solution of chlorhexidine can configure according to the concentration of the chlorhexidine of needs antibacterial in final coating.
When the volume ratio of diluent Q7-2650 and MDX4-4210 binding agent is in the range of (10:1～1:1), detecting according to above-mentioned steps, coating is one-level at the fixed effect of Silica Surface through fastness test.
Claims (3)
1. a silicone rubber antimicrobial coating, coating is prepared via a method which:
A. chlorhexidine or chlorhexidine derivant are dissolved in solvent；
B. diluent Q7-2650 is used to be diluted by MDX4-4210 bonding agent；
C. by gained liquid in step A and gained liquid mixing in step B, after adding MDX4-4210 catalyst, mix homogeneously.
2. Silicone rubber antimicrobial coating as claimed in claim 1, it is characterised in that: in step B, diluent Q7-2650 is (10:1～1:1) with the volume ratio of MDX4-4210 bonding agent.
3. silicone rubber antimicrobial coating as described in claim 1 or 2, it is characterised in that: solvent described in step A is ethyl acetate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510262994.9A CN106280977B (en) | 2015-05-21 | 2015-05-21 | Silicone rubber antibacterial coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510262994.9A CN106280977B (en) | 2015-05-21 | 2015-05-21 | Silicone rubber antibacterial coating |
Publications (2)
| Publication Number | Publication Date |
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| CN106280977A true CN106280977A (en) | 2017-01-04 |
| CN106280977B CN106280977B (en) | 2019-12-27 |
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| CN201510262994.9A Active CN106280977B (en) | 2015-05-21 | 2015-05-21 | Silicone rubber antibacterial coating |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116676008A (en) * | 2023-05-26 | 2023-09-01 | 吉力水性新材料科技（珠海）有限公司 | Water-based antibacterial antistatic coating and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080161405A1 (en) * | 2006-12-29 | 2008-07-03 | Erning Xia | Biguanide Composition and Method of Treatment and Prevention of Infections |
| CN103079604A (en) * | 2010-06-17 | 2013-05-01 | 科发龙技术公司 | Antimicrobial silicone-based wound dressings |
| US20140178447A1 (en) * | 2011-08-31 | 2014-06-26 | The Trustees Of Columbia University In The City Of New York | Reduction of biofilms on medical devices |
| CN104349671A (en) * | 2012-04-03 | 2015-02-11 | 贝克顿·迪金森公司 | Systems and methods for applying novel antimicrobial coating material to medical device |
-
2015
- 2015-05-21 CN CN201510262994.9A patent/CN106280977B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080161405A1 (en) * | 2006-12-29 | 2008-07-03 | Erning Xia | Biguanide Composition and Method of Treatment and Prevention of Infections |
| CN103079604A (en) * | 2010-06-17 | 2013-05-01 | 科发龙技术公司 | Antimicrobial silicone-based wound dressings |
| US20140178447A1 (en) * | 2011-08-31 | 2014-06-26 | The Trustees Of Columbia University In The City Of New York | Reduction of biofilms on medical devices |
| CN104349671A (en) * | 2012-04-03 | 2015-02-11 | 贝克顿·迪金森公司 | Systems and methods for applying novel antimicrobial coating material to medical device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116676008A (en) * | 2023-05-26 | 2023-09-01 | 吉力水性新材料科技（珠海）有限公司 | Water-based antibacterial antistatic coating and preparation method thereof |
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| Publication number | Publication date |
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| CN106280977B (en) | 2019-12-27 |
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Inventor after: Chen Hanjie Inventor after: Ji Guowei Inventor after: Gu Fan Inventor before: Ji Guowei Inventor before: Chen Hanjie Inventor before: Gu Fan |
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