CN106266740A - One is used for treating psoriasic Chinese medicine formula - Google Patents

Abstract

The invention discloses a kind of for treating psoriasic Chinese medicine formula, including Rhizoma Imperatae 4 16 parts, Radix Arnebiae (Radix Lithospermi) 3 24 parts, Cortex Dictamni 2 12 parts, Radix Isatidis 3 18 parts, Radix Paeoniae Rubra 2 16 parts, 5 18 parts of Semen Persicae, Radix Sophorae Tonkinensis 4 16 parts, 10 30 parts of Radix Glycyrrhizae, and Rhizoma Paridis, Periostracum Cicadae and Rhizoma Chuanxiong, Radix Glycyrrhizae selects chieftain's DICAO.The Chinese medicine composition of the present invention does not in use have untoward reaction, and psoriasis treatment is had obvious effect, the medicine material chosen does not has toxic and side effects from each other, slight and severe psoriatic can use, applied widely, eliminate the erythema on skin and squama, eliminate the fire of moxibustion of health, improve the mental status.

Description

One is used for treating psoriasic Chinese medicine formula

Technical field

The present invention relates to technical field of Chinese medicines, specifically refer to a kind of for treating psoriasic Chinese medicine formula.

Background technology

Psoriasis is psoriatic being commonly called as, and is that a kind of chronic inflammatory skin is sick, and the course of disease is longer, has easy tendency of recurrence, has Case almost cannot be cured all one's life.This disease is fallen ill based on person between twenty and fifty, affects bigger on the healthy of patient and mental status.Face Bed performance is with erythema, and squama is main, and whole body all can be fallen ill, and with scalp, it is relatively conventional that extremity stretch side, increases the weight of the most in the winter time.

Its pathogenic factor is the most complicated, and it is the most invalid to carry out treating with antifungal drug.Therefore, some patient can hope Wen Sheng Justice, oneself takes antifungal drug or abuses painting outside tinea medicine, instead resulting in and waste money, increase the weight of the state of an illness.And owing to silver is considered to be worth doing Disease is owing to body interior occurs abnormal, just causes external skin impaired and the damage of people's psychiatric aspect, so in Shi Yonging Medicine can have good curative effect to psoriatic treatment.

Summary of the invention

It is an object of the invention to provide one can significantly disappear erythema, squama, alleviate skin pruritus sense, promote health The Chinese medicine composition that health level, removal health are scorching.

The present invention is achieved through the following technical solutions: one is used for treating psoriasic Chinese medicine formula, by weight, bag Include: Rhizoma Imperatae 4-16 part, Radix Arnebiae (Radix Lithospermi) 3-24 part, Cortex Dictamni 2-12 part, Radix Isatidis 3-18 part, Radix Paeoniae Rubra 2-16 part, Semen Persicae 5-18 part, mountain Radix Sophorae Tonkinensis 4-16 part, Radix Glycyrrhizae 10-30 part.

A kind of crude drug pharmacology for treating psoriasic Chinese medicine formula of the present invention:

Rhizoma Imperatae: sweet in the mouth, cold in nature.Return lung meridian, stomach warp, bladder warp.Cooling blood for hemostasis, clearing away heat and promoting diuresis.Belong in hemorrhage subordinate is cool Blood hemorrhage.

Radix Arnebiae (Radix Lithospermi): cold in nature is sweet in the mouth, salty.GUIXIN warp, Liver Channel.Removing heat from blood, invigorate blood circulation, rash of detoxifying.Belong to the clear of antipyretic subordinate classification Hot blood-cooling drugs.

Cortex Dictamni: cold in nature, bitter in the mouth.Return spleen channel, stomach warp.Heat clearing and damp drying, removing toxic substances of dispeling the wind.Belong to the heat clearing away of classification under antipyretic dry Wet medicine.

Radix Isatidis: cold in nature, bitter in the mouth.GUIXIN warp, stomach warp.Heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.Belong to the heat clearing away solution of classification under antipyretic Poison.

Radix Paeoniae Rubra: cold nature, bitter in the mouth.Return Liver Channel, spleen channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.Belong to the heat clearing away of antipyretic subordinate classification Blood-cooling drugs.Semen Persicae: property is put down, bitter in the mouth, sweet.GUIXIN warp, Liver Channel, large intestine channel.Activating blood circulation and dissipating phlegm, loosening bowel to relieve constipation.Belong under drug for invigorating blood circulation and eliminating stasis Belong to the blood-activating and menstruation-regulating medicinal of classification.

Radix Sophorae Tonkinensis: cold in nature, bitter in the mouth is poisonous.Return lung meridian, stomach warp.Heat-clearing and toxic substances removing, detumescence sore-throat relieving.Belong to classification under antipyretic Heat and toxic materials clearing away medicine.

Radix Glycyrrhizae: property is put down, sweet in the mouth.GUIXIN warp, stomach warp, spleen channel, lung meridian.Invigorating the spleen and replenishing QI, eliminating phlegm and stopping cough, emergency analgesic therapy, mediation The property of medicine.Belong to the Qi-tonifying drug of classification under qi-restoratives medicine.

For optimizing the effect of drugs of medicine, further, described Rhizoma Imperatae 10 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Cortex Dictamni 10 parts, Baphicacanthus cusia Root 15 parts, Radix Paeoniae Rubra 12 parts, 16 parts of Semen Persicae, Radix Sophorae Tonkinensis 13 parts, 21 parts of Radix Glycyrrhizae.

Further, in order to improve extraction effect of drugs, present invention additionally comprises: Rhizoma Paridis 3-23 part, Periostracum Cicadae 5-25 part, Rhizoma Chuanxiong 4-15 part.

Further, described Chinese medicine composition includes the raw material of following weight portion:

Rhizoma Imperatae 10 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Cortex Dictamni 10 parts, Radix Isatidis 15 parts, Radix Paeoniae Rubra 12 parts, 16 parts of Semen Persicae, Radix Sophorae Tonkinensis 13 parts, sweet Grass 21 parts, Rhizoma Paridis 20 parts, Periostracum Cicadae 10 parts, Rhizoma Chuanxiong 13 parts.

Further, described Radix Glycyrrhizae selects chieftain's DICAO.

The Chinese medicine composition of the present invention does not in use have untoward reaction, and has psoriasis treatment significantly Effect, the medicine material chosen does not has toxic and side effects from each other, and slight and severe psoriatic can use, and is suitable for model Enclose wide, eliminate the erythema on skin and squama, eliminate the fire of moxibustion of health, improve the mental status.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention is not limited to this, Without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, make various replacing Change and change, all should be included within the scope of the invention.

Embodiment 1:

One described in the present embodiment is used for treating psoriasic Chinese medicine formula, by weight, including: Rhizoma Imperatae 4-16 part, purple Grass 3-24 part, Cortex Dictamni 2-12 part, Radix Isatidis 3-18 part, Radix Paeoniae Rubra 2-16 part, Semen Persicae 5-18 part, Radix Sophorae Tonkinensis 4-16 part, Radix Glycyrrhizae 10- 30 parts.

The preparation method of medicine of the present invention, comprises the following steps:

(1) represent with weight portion, weigh Rhizoma Imperatae 4-16 part, Radix Arnebiae (Radix Lithospermi) 3-24 part, Cortex Dictamni 2-12 part, Radix Isatidis 3-18 part is red Chinese herbaceous peony 2-16 part, Semen Persicae 5-18 part, Radix Sophorae Tonkinensis 4-16 part, Radix Glycyrrhizae 10-30 part；

(2) by above-mentioned whole raw material of Chinese medicine medicines, to soak 30 minutes with clear water or pure water in advance, water consumption for immersion is 0.9 ~ 1.1L；

(3) raw material of Chinese medicine medicine and the liquid medicine of immersion thereof after soaking join in decocting container, add a cover and jointly decoct；

(4) first make decocting container herb liquid seethe with excitement with high heat, re-use slow fire and boil, need to stir when boiling medicine 2 ~ 3 times；

(5) after having decocted, add proper amount of clear water or pure water did not had medicine, carry out second time and decoct, decoct duration and degree of heating method ibid；

(6) leaching medicinal liquid, obtained medicinal liquid is endo-medicine.

Embodiment 2:

It is used for treating psoriasic Chinese medicine formula described in the present embodiment, by weight, including: Rhizoma Imperatae 10 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Cortex Dictamni 10 parts, Radix Isatidis 15 parts, Radix Paeoniae Rubra 12 parts, 16 parts of Semen Persicae, Radix Sophorae Tonkinensis 13 parts, 21 parts of Radix Glycyrrhizae.

Embodiment 3:

The present embodiment is on the basis of above-described embodiment, further, also includes Rhizoma Paridis 3-23 part, Periostracum Cicadae 5-25 part, Rhizoma Chuanxiong 4- 15 parts.The most originally it is used for treating psoriasic Chinese medicine formula, by weight, including: Rhizoma Imperatae 10 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Cortex Dictamni 10 parts, Radix Isatidis 15 parts, Radix Paeoniae Rubra 12 parts, 16 parts of Semen Persicae, Radix Sophorae Tonkinensis 13 parts, 21 parts of Radix Glycyrrhizae, Rhizoma Paridis 20 parts, Periostracum Cicadae 10 parts, Rhizoma Chuanxiong 13 parts

Other parts of the present embodiment are same as the previously described embodiments, repeat no more.

Embodiment 4

The present embodiment provides this toxicology test being used for treating psoriasic Chinese medicine formula, specific as follows:

Acute toxicity test:

Experimental observation, because measuring LD50, therefore has carried out the mensuration of maximum dosage-feeding.Chinese medicine composition prepared by embodiment 1 Thing is dissolved in sterile saline, is configured to solution gavage mice, and result shows, raw with medicine maximum administration concentration 9.65 Medicine/ml, the maximum volume 50ml/kg that is administered were administered twice to mouse stomach in 24 hours, and mice maximum dosage-feeding is 763.25g Crude drug/kg, there is not untoward reaction and death in animal, anatomic observation each internal organs no abnormality seen.

Long term toxicity test:

This test application SD rat 80, is dissolved in Chinese medicine composition prepared by embodiment 1 in sterile saline, is configured to Solution gavage, if matched group and 24g, 35g, 49g crude drug/kg dosage group, continuous gastric infusion 12 weeks, observes the Chinese medicine of the present invention The compositions impact on animal indices.Result of the test shows, successive administration 12 weeks, the Chinese medicine composition of the present invention is to rat Body weight, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. all have no significant effect；Blood biochemical ten binomial Index determining result, is administered 12 weeks low dose group BiLi values higher than matched group (P < 0.05)；Low dose group, middle dosage group TP value are high In matched group (P < 0.05), but all within normal physiologic range, other index compares no significant difference with matched group.Convalescent period Each administration group indices measured value compares equal no significant difference with matched group.The each internal organs gross examination of skeletal muscle no abnormality seen of each group.

The using method of medicine of the present invention: directly take orally.

Utilize medicine of the present invention for the clinical statistics data of various psoriatics:

Through the Clinical practice of 200 example patients, wherein man patient 114, female patient 86 example, medication age object 20-64 year.Wherein Minimum 20 years old, maximum 64 years old, 39 years old mean age.

Model case:

1, Zhao, female, 42 years old, workman.Because flu causes psoriasis in 6 years old time, give extract oral and external through department of dermatologry Take a turn for the better after medicinal ointment therapy.Thereafter irregularly show effect again for several times, take a turn for the better through same approach treatment again.After before 10 years, because of in family Retail shop's fire accident and worry and get angry and feel blue, hurriedly and emotion is impatient, the state of an illness is shown effect, erythema, squama throughout all over the body, then in order to Front Regimen Chemotherapy has no curative effect, does not heals through multiple therapy for treating again, and mood is more irritable, enters you manic, hits the person and ruin thing, morbidity Time, need several stout mans could prevent, send mental hospital of Shenyang City, be diagnosed as manic type schizophrenia, in addition compulsory treatment, delay Leave hospital after solution, monthly still need to oral anti-schizophrenia Drug therapy, but still frequently show effect, again with serious insomnia, overwhelmed with sorrow, Often having suicidal thoughts, household is the most agonizing, carrys out diagnosis and treatment on May 16th, 2014 and treats psoriasis, looks into sight the most dull, voice Irritability impulsion, the whole body spreads all over erythema, squama, merges in flakes, chap, hemorrhage, pruritus, all scorching fever in the body, increases the weight of night, with nervous Thirsty, weak, anorexia, arthralgia, fingernail spreads all over pit, and the menstruation several months is the most damp, the few tongue of red tongue, thready and rapid pulse.Examine for Severe psoriasis, poison heated is contained, and has involved internal organs, has blinded the mind, therefore have the syndromes such as abnormal mind, insomnia, has controlled its root the most all Disease, from when disappearing, advises it to withdraw treatment schizophrenia and all medicines of having a sleepless night, and gives Chinese medicine decoction and is administered orally, uses the embodiment of the present invention 2 Prescription check after 10 days, the manic symptom of readme is not shown effect, and angry number of times significantly reduces, and the most still feels unhappy, arthritis Pain slightly alleviates, and when taking 5 days, pruritus aggravation, the most gradually alleviates, look into chap, bleeding alleviates, scorching hot alleviate, other symptoms Have no and be clearly better, red tongue, thready and rapid pulse, still take front.Checking after 20 days, pruritus substantially alleviates, angry number of times and pass Joint pain significantly reduce, chap, bleeding disappear, scorching hot transference cure, erythema color and luster alleviates, sleep slightly get better turn, all over the body Squama has no and alleviates, and continues to take front.Checking after 30 days, pruritus substantially alleviates, and squama is the most thinning, and appetite strengthens, five hearts The anesthesia of dysphoria with smothery sensation, irritable transference cure keeps one's hair on, no longer has suicidal thoughts, and the conscious mental status is good, it is possible to Going out and others' normal communication, red tongue, thready pulse is several, and defence is constant, continues to take.After 60 days, squama is thinning all over the body, tiny Erythema, squama disappear, micro-itch, and sleep state is also clearly better, and remaining symptom disappears substantially, still takes front.Take medicine 4 altogether Checking after Yue, erythema, squama major part disappear all over the body, and normally, the whole body still feels tired in sleep, and red tongue, thin fur, thready pulse continue Continue and take front.Checking after taking medicine 5 months, erythema, squama disappear the most completely all over the body, can normally go to work, and the whole body slightly feels tired, Red tongue, thin fur, thready pulse, the author thinks that this ill long poison is deep, also needs to take front 1 month to consolidate curative effect though recovering again.6 months After, tired sense also disappears, and muscle power is recovered completely, clinical cure, and drug withdrawal then recovers orthobiosis.Paying a return visit after 1 year, psoriasis has no Recurrence, health is also abnormal without other.

2, female, 35 years old, suffers from psoriasis 8 years.Nearly 1 year, symptom substantially increased the weight of, and erythema, squama are stretched all over the body, acute pruritus, Night increases the weight of, and feels depressed, total suspect have people key she, no matter must someone keep company with at daytime, night, go the toilet also must be with Household, with going, dare not go out, tell outside window and doorway always has stranger and evil spirit to haunt, often shied by nightmare in dream during night Wake up, scared out of one's wits, dare not sleep again, the state of an illness grows with each passing day, and household is the most agonizing.Within 22nd, examine in JIUYUE in 2013, look into shape Body is become thin, and mesh is color without god, tried out can't bear, and the whole body spreads all over the erythema that differs in size, overlying lamellar squama, peels off mesh-like seen from squama Hemorrhage, spread all over scratch, tongue body is thin, the red no fur of matter, thready and rapid pulse.Examine as psoriasis (poison heated contain), because poison fire is disturbed and gods, therefore have Mental symptoms.For its etiology and pathogenesis, give clearing away heat,cooling blood and removing toxin.The prescription using the embodiment of the present invention 2 is multiple after taking orally 10 days Looking into, when reflection is taken medicine 4 days, pruritus is more violent, and a lot of tiny erythema, squama occurs again, and within nearly 2 days, pruritus alleviates, erythema, squama Bits no longer have more, and gradually decrease, and fear still suffers from, but slightly alleviates, and has and wake up with a start time in dream still, but can continue to sleep, and looks into Erythema color and luster alleviates all over the body, and scratch reduces, and red tongue, thready and rapid pulse, defence is constant.Checking after 20 days, pruritus substantially alleviates all over the body, Erythema, squama start to reduce, and fear alleviates, and slightly can stable live in the comfort of layman, and household is slightly off a moment also Not fearing, can go alone toilet, though sleep is the most stable, but not waking up with a start, red tongue, arteries and veins is slightly shown in gentle phase, continues and takes front. Checking after 30 days, erythema, squama significantly reduce, the whole body the most not pruritus, can treat alone at home daytime, and layman also may be used under accompanying Short time outdoor activity, sleeps stable, red tongue, and normal pulse delays, and continues and takes front.Checking during 1 first quarter moon, the whole body only has the reddest Speckle, other skin lesion disappear, the most frightened, and antisecosis is a lot, can individually outdoor activity, it is possible to arbitrarily talk with others, Red tongue, thin fur, normal pulse delays, because it is sick for a long time, advise its again the side's of taking medicine two weeks check again.Expire check time, the whole body without red Speckle, squama, skin smooth as before, without frightened, is slept the most stable, can be gone out normally to go to work.

Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that: not Depart from and these embodiments can be carried out multiple change under the principle of the present invention and objective, revise, replace and modification, the present invention's Scope is limited by claim and equivalent thereof.

Claims (5)

1. one kind is used for treating psoriasic Chinese medicine formula, it is characterised in that by weight, including: Rhizoma Imperatae 4-16 part, purple Grass 3-24 part, Cortex Dictamni 2-12 part, Radix Isatidis 3-18 part, Radix Paeoniae Rubra 2-16 part, Semen Persicae 5-18 part, Radix Sophorae Tonkinensis 4-16 part, Radix Glycyrrhizae 10- 30 parts.

One the most according to claim 1 is used for treating psoriasic Chinese medicine formula, it is characterised in that described Rhizoma Imperatae 10 Part, Radix Arnebiae (Radix Lithospermi) 15 parts, Cortex Dictamni 10 parts, Radix Isatidis 15 parts, Radix Paeoniae Rubra 12 parts, 16 parts of Semen Persicae, Radix Sophorae Tonkinensis 13 parts, 21 parts of Radix Glycyrrhizae.

One the most according to claim 1 and 2 is used for treating psoriasic Chinese medicine formula, it is characterised in that by weight Meter, also includes: Rhizoma Paridis 3-23 part, Periostracum Cicadae 5-25 part, Rhizoma Chuanxiong 4-15 part.

One the most according to claim 3 is used for treating psoriasic Chinese medicine formula, it is characterised in that this Chinese medicine composition Raw material including following weight portion:

Rhizoma Imperatae 10 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Cortex Dictamni 10 parts, Radix Isatidis 15 parts, Radix Paeoniae Rubra 12 parts, 16 parts of Semen Persicae, Radix Sophorae Tonkinensis 13 parts, sweet Grass 21 parts, Rhizoma Paridis 20 parts, Periostracum Cicadae 10 parts, Rhizoma Chuanxiong 13 parts.

One the most according to claim 1 and 2 is used for treating psoriasic Chinese medicine formula, it is characterised in that described Radix Glycyrrhizae Select chieftain's DICAO.