CN106266609A - A kind of Herba Dendrobii micropowder sheet and preparation method thereof - Google Patents
A kind of Herba Dendrobii micropowder sheet and preparation method thereof Download PDFInfo
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- CN106266609A CN106266609A CN201610710364.8A CN201610710364A CN106266609A CN 106266609 A CN106266609 A CN 106266609A CN 201610710364 A CN201610710364 A CN 201610710364A CN 106266609 A CN106266609 A CN 106266609A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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Abstract
The invention belongs to medicine and health product technology field, particularly to a kind of Herba Dendrobii micropowder sheet and preparation method thereof.The Herba Dendrobii micropowder sheet of the present invention is prepared at the Herba Dendrobii micropowder of 0.01 ~ 300 μm at 0.1 ~ 25%wt, particle diameter only with water content；The present invention additionally provides the preparation method of Herba Dendrobii micropowder sheet simultaneously, controls its moisture after fresh for the defoliation Herba Dendrobii direct attrition grinding of bar, and being pelletized by dry or wet obtains Herba Dendrobii micropowder sheet.The invention has the beneficial effects as follows, Herba Dendrobii micropowder sheet of the present invention and preparation method thereof can be implemented in without directly preparing the pure tablet not containing non-Herba Dendrobii composition under conditions of any adjuvant, and the tablet prepared has and comprises only the feature of Herba Dendrobii composition and tablet properties meets relevant national standard；The production process of Herba Dendrobii micropowder sheet can directly use the fresh bar of Herba Dendrobii as raw material, it is no longer necessary to uses air-dried Dendrobium powder, simplifies production technology, and the tablet quality made is more preferable compared with prior art.
Description
Technical field
The invention belongs to medicine and health product technology field, particularly to a kind of Herba Dendrobii micropowder sheet and preparation method thereof.
Background technology
Herba Dendrobii (formal name used at school: DendrobiumnobileLindl), have another name called celestial dry measure used in former times orchid rhythm, Radix Ophiopogonis, Herba Hylothelephii Verticillati, purple entangle celestial strain,
Bracketplant, Lin Lan, raw, the Dendrobium nobile Lindl flower of taboo etc..It eats frequently as Chinese crude drug, and this year to its effect and takes safety due to everybody
Affirmative, State Food and Drug Administration intend as new resource food, the effect of its health care will make more extensive
People's income.Herba Dendrobii is usually used in cloudy impairment of body fluid and loses, xerostomia excessive thirst, and lack of appetite is retched, deficiency-heat after being ill, poor vision.
Herba Dendrobii experienced by the applicating history of more than 2000 in China's traditional medicine kind, uses till today from Gu, has preferably
Curative effect, plants at " Chinese Pharmacopoeia ", and it is two that Dendrobium Sw is recorded: Herba Dendrobii and Herba Dendrobii.Wherein the source of Herba Dendrobii is blue
Section's plant Dendrobium nobile, Dendrobium chrysotoxum or Dendrobium fimbriatum Hook. and the fresh or dry stem of congener allied species thereof.And Herba Dendrobii
Carrying in Dendrobium Sw and have certain particularity, tradition thinks the superfine product that Herba Dendrobii is Herba Dendrobii, and modern study also demonstrates that, relatively
Other kind of Chinese medicine of Dendrobium, polysaccharide content of dendrobium candidum is higher, and YIN nourishing effect is more notable.
The human body of Herba Dendrobii is taken in and is used powder, tablet, fresh bar and three kinds of modes of dry product, owing to tablet has just at present
In carrying, taking convenience and the feature such as be easily absorbed by the human body, therefore the mode of Herba Dendrobii tablet is more favourable.Simultaneously because state
Tablet is had specific requirement, product need to meet the requirements such as the friability in circulation and hardness by family, and Herba Dendrobii is without adjuvant
In the case of, pure raw material is difficult to be pressed in flakes, and therefore Herba Dendrobii tablet all needs to add other auxiliary agents to help iron sheet at present
Herba Dendrobii molding.And the tablet that other adjuvants of interpolation compared in terms of raw material genuineness and effect by pure Herba Dendrobii tablet has
Unique superiority, therefore development dendrobium candidum wallex lindll pure powder tablets will have considerable market application potential.
The preparation method of existing Herba Dendrobii tablet mainly uses with Herba Dendrobii micropowder as major ingredient, adds non-Herba Dendrobii
Adjuvant helps the way of molding, is prepared by compressing dry granulation or forming technique.As patent 201310195063.2 (containing Herba Dendrobii and
Compound buccal tablet of Flos Lonicerae and preparation method thereof) in have employed the adjuvants such as white sugar powder, magnesium stearate and micropowder silica gel；Patent
In 201110390606.7 (a kind of Traditional Chinese medicine dendrobium candidum buccal tablets) preparation of Herba Dendrobii buccal tablet add substantial amounts of filler,
Binding agent, fluidizer and lubricant；In patent 200910101997.9 (a kind of dendrobium candidum polysaccharide buccal tablet and preparation method thereof)
Add the adjuvants such as xylitol, aspartame, magnesium stearate, micropowder silica gel too.Reduction Herba Dendrobii is had by the addition of adjuvant
The content of effect composition, reduces effect of Herba Dendrobii.Therefore, the preparation method of research Pure dendrobium officinale kimura et migo tablet increasingly causes
The attention of people, prepares 100% as mentioned one in patent CN 104605343 A (Herba Dendrobii buccal tablet and preparation method thereof)
The method of Pure dendrobium officinale kimura et migo buccal tablet, its method makes binding agent, so by addition water or ethanol in dendrobium candidum ultrafine powder
After replace with the binding agent prepared and other patented methods to be added the way of adjuvant synthesize Pure dendrobium officinale kimura et migo buccal tablet.The method
Deficiency be during Herba Dendrobii buccal tablet to need add and remove alcohol solvent, add Herba Dendrobii tablet and prepare
Add volume residual while cost and make final products introduce the risk of impurity due to the addition of solvent.
Summary of the invention
The technical problem to be solved in the present invention is: overcome Herba Dendrobii micropowder sheet in prior art to be both needed to add the deficiency of adjuvant,
Provide a kind of Herba Dendrobii micropowder sheet without any adjuvant.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Herba Dendrobii micropowder sheet, exists only with water content
0.1～25%wt, particle diameter is prepared at the Herba Dendrobii micropowder of 0.01～300 μm.
Second the invention solves the problems that technical problem is that: overcome Herba Dendrobii micropowder sheet in prior art to be both needed to add adjuvant
Not enough, it is provided that a kind of Herba Dendrobii micropowder piece preparation method without any adjuvant.
The present invention solves second technical problem and be the technical scheme is that the preparation method of a kind of Herba Dendrobii micropowder sheet,
Comprise the steps:
(1) by the fresh bar of defoliation Herba Dendrobii of washes clean direct attrition grinding under the conditions of-80～120 DEG C, fiber is obtained big
The little pureed Herba Dendrobii in 0.01～5000 μm, the moisture of pureed Herba Dendrobii is 40～93%；
(2) the pureed Herba Dendrobii that drying steps (1) obtains under the conditions of 30～250 DEG C so that the Herba Dendrobii obtained after drying is done
The water content of product is 0.1～25%wt；
(3) above-mentioned dry product is pulverized again, obtain particle diameter at 0.01～300 μm Herba Dendrobii micropowder；
(4) by compressing dry granulation, at tableting pressure between 3.18～55.7kN, Herba Dendrobii micropowder is prepared Herba Dendrobii micropowder sheet
Finished product.
Preferably, in described step (1), the moisture of pureed Herba Dendrobii is 40～93%wt.The moisture of pureed Herba Dendrobii
Relevant to the kind of the raw material fresh bar of defoliation Herba Dendrobii and freshness.
Preferably, in described step (2), the water content of air-dried Dendrobium is 0.1～10%wt；Further, described step
(2) in, the water content of air-dried Dendrobium is 0.1～6%wt.
Preferably, in described step (3), the particle diameter of Herba Dendrobii micropowder is 1.3～300 μm；Further, in described step (3)
The particle diameter of Herba Dendrobii micropowder is 1.3～150 μm.
Present invention also offers the preparation method of another kind of Herba Dendrobii micropowder sheet, comprise the steps:
(1) by fresh for Herba Dendrobii bar at-80～120 DEG C of bars after adding appropriate solvent in the fresh bar of defoliation Herba Dendrobii of washes clean
The pulpous state Herba Dendrobii obtaining fiber grain size in 0.01～300 μm, total solid in described pulpous state Herba Dendrobii it is directly ground under part
Content≤7%wt；
(2) the pulpous state Herba Dendrobii drying of acquisition is obtained the pureed Herba Dendrobii that total solids content is 7～60%wt；
(3) being pelletized by dry or wet by the pureed Herba Dendrobii that step (2) obtains, tabletting prepares Herba Dendrobii micropowder sheet.
Preferably, described wet granulation comprises the steps:
A., after pureed Herba Dendrobii being crossed 18-24 mesh sieve, it is dried under the conditions of 30～250 DEG C so that total solids content is 75
～the air-dried Dendrobium of 99.9%wt, obtain granule；
B., between tableting pressure 3.18～55.7kN, granule compacting is obtained Herba Dendrobii micropowder sheet finished product.
Preferably, described dry granulation comprises the steps:
A. under the conditions of 30～250 DEG C, pureed Herba Dendrobii it is dried so that the water content of the air-dried Dendrobium obtained after drying is 0.1
～25%wt；
B. by compressing dry granulation, at tableting pressure between 3.18～55.7kN, air-dried Dendrobium is made Herba Dendrobii micropowder sheet
Finished product.
Preferably, described solvent be water, propanol, triethyl citrate, propylene glycol, ethanol, methanol, acetone, sec-butyl alcohol, 1,
3-butanediol, acetum, thiacyclohexane, dichloromethane, ether, diethyl tartrate., dichloroethanes, diacetine, one
Acetin, hexane, isopropanol, isopropyl myristate, petroleum ether, nitropropane, toluene, trichloro ethylene, trichlorine trifluoro
One or more in ethane, alkanes or No. six light gasoline；Further, described solvent is the water-soluble of water, ethanol or ethanol
Liquid.
Preferably, in described step (1), total solids content≤6%wt in pulpous state Herba Dendrobii；
Preferably, the interpolation quality of described solvent is 0.2～20 times of defoliation Herba Dendrobii fresh bar quality；Further, described
The interpolation quality of solvent is 1～20 times of defoliation Herba Dendrobii fresh bar quality.
Preferably, in step (3) total solids content of air-dried Dendrobium 90～99.9%wt.
Present invention also offers another method preparing Herba Dendrobii micropowder sheet as claimed in claim 1, it is characterised in that
Comprise the following steps:
(1) washes clean, water content are squeezed the juice at the fresh bar of defoliation Herba Dendrobii of 40～93%wt, be directly separated or by centrifugal
Separate liquid and fiber part, then by fiber attrition grinding under the conditions of-80～120 DEG C, obtain fiber size 0.01～
Powder between 300 μm；Moisture in described fiber is 0～20%wt；
(2) juice and fiber dust step (1) obtained uniformly mixes, and is dried under the conditions of 30～250 DEG C so that dry
The water content of the air-dried Dendrobium obtained after dry is 0.1～25%wt；
(3) between tableting pressure 3.18～55.7kN, granule compacting is obtained Herba Dendrobii sheet finished product.
Preferably, the fresh bar of described Herba Dendrobii refers to Herba Dendrobii, Herba Dendrobii, Dendrobium nobile, dendrobium moniliformeSweet, U.S. flower stone
Dry measure used in former times, Dendrobium chrysanthum, Herba Dendrobii, dendrobium, Dendrobium fimbriatum Hook., Dendrobium thyrsiflorum, Dendrobium devonianum Part., Dendrobium chrysotoxum, weight lip Herba Dendrobii, song
Stem Herba Dendrobii, little Dendrobium tosaense Makino, comb lip Herba Dendrobii, south, Tibetan Herba Dendrobii, Dendrobium crepidatum lindl et paxt．, brilliant cap Herba Dendrobii, Dendrobium aphyllum (Roxb.) C. E. Fisch．, cup sheath Herba Dendrobii, spire
Herba Dendrobii, Dendrobium falconeri Hook．, Dendrobium henryi Schltr. or the fresh bar of big bud sheath Herba Dendrobii.
The invention has the beneficial effects as follows, Herba Dendrobii micropowder sheet of the present invention and preparation method thereof can be implemented in without any
Directly preparing the pure tablet not containing non-Herba Dendrobii composition under conditions of adjuvant, the tablet prepared has and comprises only iron sheet
Feature and the tablet properties of Herba Dendrobii composition meet relevant national standard；The production process of Herba Dendrobii micropowder sheet can directly use stone
The fresh bar of dry measure used in former times is as raw material, it is no longer necessary to uses air-dried Dendrobium powder, simplifies production technology, and the tablet quality made is more existing
In technology more preferably.
Detailed description of the invention
After inventor finds Herba Dendrobii dry product is directly crushed to 50～300 μm under study for action, auxiliary without film-making
Time in the case of material with dry method direct compression, when film-making pressure is less than 15.9KN, obtained by it, tablet hardness is along with film-making pressure
The increase of power and increase；When film-making pressure is higher than 15.9KN, the hardness of tablet obtained by it is on the contrary along with the increasing of film-making pressure
Adding and reduce, tracing it to its cause, this is caused not mainly due to the bonding dynamics of powder after Herba Dendrobii pulverizing.Meanwhile, we go back
It can be seen that the highest hardness of obtained tablet only has about 1.18Kg, and tablet surface is coarse, if making product by nothing
Method meets national requirements and cannot meet the loss-free requirement of Product transport process.For overcoming Herba Dendrobii powder bonding force degree
Low problem, inventor is found by fresh for the Herba Dendrobii direct precomminution of bar by research, and then after drying and crushing, tabletting is permissible
Prepared tablet properties meets the tablet of requirement, thus have developed a kind of Herba Dendrobii micropowder sheet without non-Herba Dendrobii composition and
Preparation method.
Embodiment 1:
The concrete preparation method of the present embodiment is as follows:
(1) fibre length is become to exist the fresh bar of defoliation Herba Dendrobii of washes clean direct attrition grinding under the conditions of-80 DEG C
Between 0.01～5000 μm, thus obtain the pureed Herba Dendrobii that water content is about 93%；
(2) the pureed Herba Dendrobii obtained is dried, under the conditions of 100 DEG C, be dried to obtain the Herba Dendrobii that water content is about 0.5%
Dry product；
(3) air-dried Dendrobium is carried out under the conditions of-80 DEG C micronizing to fine particle, obtain particle diameter at 0.01～1.3 μ
M Herba Dendrobii micropowder；
(4) by compressing dry granulation, at tableting pressure at 15.9kN, Herba Dendrobii micropowder is prepared Herba Dendrobii micropowder sheet.
Sample analysis:
1. tablet hardness test
Initially with direct Herba Dendrobii Herba Dendrobii extract pulverize prepare micropowder direct compression, tableting pressure respectively at 15.9kN,
Prepare 24 samples respectively, use 24 samples that the inventive method is prepared under 15.9kN tableting pressure as contrast simultaneously
Test.Then use the hardness of the sample of the YD-1 type tablet hardness instrument above-mentioned preparation of test, and calculate its meansigma methods for right
Ratio, experimental result is listed in table 1. as can be seen from the table, and under this film-making pressure, the hardness of tablet is more or less the same, and tablet is hard
Degree bucket is at about 1.1Kg.Therefore, the hardness difference of the inventive method its tablet when lower pressure is inconspicuous.
Table 1: different flaking method tablet hardness comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 15.9 | 15.9 |
| Tablet hardness (Kg) | 1.18 | 1.13 |
2. tablet friability test
Using direct Herba Dendrobii Herba Dendrobii extract to pulverize the micropowder direct compression prepared, tableting pressure is respectively at 15.9kN, respectively
Preparing 24 samples, 24 samples simultaneously using the inventive method to prepare under 15.9kN tableting pressure are surveyed as contrast
Examination.Then use CS-2 type tablet friability tester, use 25 revs/min, the above-mentioned preparation of condition test of turntable rotation 100 circle
The friability of sample, and calculate its meansigma methods for contrasting, experimental result is listed in table 2.This is can be seen that by data in table
Bright method can be greatly increased the anti-friability ability of tablet under identical film-making pressure, the tablet that commonsense method obtains via
Occurring to crack completely during friability experiment, and its friability of the inventive method only has 0.2%, therefore, the inventive method has substantially
Improve the beneficial effect of tablet friability.
Table 2: different flaking method tablet friability comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 15.9 | 15.9 |
| Friability (%) | Fragmentation completely | 0.2 |
Embodiment 2:
The concrete preparation method of the present embodiment is as follows:
(1) fibre length is become to exist the fresh bar of defoliation Herba Dendrobii of washes clean direct attrition grinding under the conditions of 120 DEG C
Between 0.01～5000 μm, thus obtain the pureed Herba Dendrobii that water content is about 80%；
(2) the pureed Herba Dendrobii obtained is dried, under the conditions of 250 DEG C, be dried to obtain the Herba Dendrobii that water content is about 0.1%
Dry product；
(3) air-dried Dendrobium is carried out under the conditions of 120 DEG C micronizing to fine particle, obtain particle diameter in 1.3～48 μm
Herba Dendrobii micropowder；
(4) by compressing dry granulation, at tableting pressure at 3.18kN, Herba Dendrobii micropowder is prepared Herba Dendrobii micropowder sheet.
Sample analysis:
1. tablet hardness test
Initially with direct Herba Dendrobii Herba Dendrobii extract pulverize prepare micropowder direct compression, tableting pressure respectively at 3.18kN,
Prepare 24 samples respectively, use 24 samples that the inventive method is prepared under 3.18kN tableting pressure as contrast simultaneously
Test.Then use the hardness of the sample of the YD-1 type tablet hardness instrument above-mentioned preparation of test, and calculate its meansigma methods for right
Ratio, experimental result is listed in table 3. as can be seen from the table, and under this film-making pressure, the hardness of tablet is more or less the same, and tablet is hard
Degree is at about 1.1Kg.Therefore, the hardness difference of the inventive method its tablet when lower pressure is inconspicuous.
Table 3: different flaking method tablet hardness comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 3.18 | 3.18 |
| Tablet hardness (Kg) | 1.12 | 1.10 |
2. tablet friability test
Using direct Herba Dendrobii Herba Dendrobii extract to pulverize the micropowder direct compression prepared, tableting pressure is respectively at 3.18kN, respectively
Preparing 24 samples, 24 samples simultaneously using the inventive method to prepare under 3.18kN tableting pressure are surveyed as contrast
Examination.Then use CS-2 type tablet friability tester, use 25 revs/min, the above-mentioned preparation of condition test of turntable rotation 100 circle
The friability of sample, and calculate its meansigma methods for contrasting, experimental result is listed in table 4.This is can be seen that by data in table
Bright method can be greatly increased the anti-friability ability of tablet under identical film-making pressure, the tablet that commonsense method obtains via
Occurring to crack completely during friability experiment, and its friability of the inventive method only has 0.6%, therefore, the inventive method has substantially
Improve the beneficial effect of tablet friability.
Table 4: different flaking method tablet friability comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 3.18 | 3.18 |
| Friability (%) | Fragmentation completely | 0.6 |
Embodiment 3:
The concrete preparation method of the present embodiment is as follows:
(1) fibre length is become to exist the fresh bar of defoliation Herba Dendrobii of washes clean direct attrition grinding under the conditions of-20 DEG C
Between 0.01～5000 μm, thus obtain the pureed Herba Dendrobii that water content is about 85%；
(2) will obtain pureed Herba Dendrobii dry, be dried to obtain under the conditions of 40 DEG C water content about 25% Herba Dendrobii do
Product；
(3) air-dried Dendrobium is carried out under the conditions of-20 DEG C micronizing to fine particle, obtain particle diameter at 48～75 μm stones
Dry measure used in former times micropowder；
(4) by compressing dry granulation, at tableting pressure at 23.85kN, Herba Dendrobii micropowder is prepared Herba Dendrobii micropowder sheet.
Sample analysis:
1. tablet hardness test
Initially with direct Herba Dendrobii Herba Dendrobii extract pulverize prepare micropowder direct compression, tableting pressure respectively at 23.85kN,
Prepare 24 samples respectively, use 24 samples that the inventive method is prepared under 23.85kN tableting pressure as right simultaneously
Than test.Then use YD-1 type tablet hardness instrument to test the hardness of sample of above-mentioned preparation, and calculate its meansigma methods for
Contrast, experimental result is listed in table 5. as can be seen from the table, and under this film-making pressure, the hardness difference of tablet is relatively big, directly
The tablet hardness that the method for tabletting is prepared only has 0.80Kg, and the relatively direct pressure of tablet hardness prepared by the inventive method
Sheet method is greatly improved, and its tablet hardness reaches 1.65Kg.Therefore, the inventive method its tablet hard when elevated pressures
Degree promotes substantially.
Table 5: different flaking method tablet hardness comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 23.85 | 23.85 |
| Tablet hardness (Kg) | 0.80 | 1.65 |
2. tablet friability test
Using direct Herba Dendrobii Herba Dendrobii extract to pulverize the micropowder direct compression prepared, tableting pressure is respectively at 23.85kN, respectively
Preparing 24 samples, 24 samples simultaneously using the inventive method to prepare under 23.85kN tableting pressure are surveyed as contrast
Examination.Then use CS-2 type tablet friability tester, use 25 revs/min, the above-mentioned preparation of condition test of turntable rotation 100 circle
The friability of sample, and calculate its meansigma methods for contrasting, experimental result is listed in table 6.This is can be seen that by data in table
Bright method can be greatly increased the anti-friability ability of tablet under identical film-making pressure, the tablet that commonsense method obtains via
Occurring to crack completely during friability experiment, and its friability of the inventive method is less than 0.1%, therefore, the inventive method has substantially
Improve the beneficial effect of tablet friability.
Table 6: different flaking method tablet friability comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 23.85 | 23.85 |
| Friability (%) | Fragmentation completely | <0.1 |
Embodiment 4:
The concrete preparation method of the present embodiment is as follows:
(1) fibre length is become to exist the fresh bar of defoliation Dendrobium nobile of washes clean direct attrition grinding under the conditions of-10 DEG C
Between 0.01～5000 μm, thus obtain the pureed Herba Dendrobii that water content is about 60%；
(2) will obtain pureed Herba Dendrobii dry, be dried to obtain under the conditions of 80 DEG C water content about 10% Herba Dendrobii do
Product；
(3) air-dried Dendrobium is carried out under the conditions of-10 DEG C micronizing to fine particle, obtain particle diameter in 75～150 μm
Herba Dendrobii micropowder；
(4) by compressing dry granulation, at tableting pressure at 31.80kN, Herba Dendrobii micropowder is prepared Herba Dendrobii micropowder sheet.
Sample analysis:
1. tablet hardness test
Initially with direct Herba Dendrobii Herba Dendrobii extract pulverize prepare micropowder direct compression, tableting pressure respectively at 31.80kN,
Prepare 24 samples respectively, use 24 samples that the inventive method is prepared under 31.80kN tableting pressure as right simultaneously
Than test.Then use YD-1 type tablet hardness instrument to test the hardness of sample of above-mentioned preparation, and calculate its meansigma methods for
Contrast, experimental result is listed in table 7. as can be seen from the table, and under this film-making pressure, the hardness difference of tablet is relatively big, directly
The tablet hardness that the method for tabletting is prepared only has 0.75Kg, and the relatively direct pressure of tablet hardness prepared by the inventive method
Sheet method is greatly improved, and its tablet hardness reaches 1.96Kg.Therefore, the inventive method its tablet hard when elevated pressures
Degree promotes substantially.
Table 7: different flaking method tablet hardness comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 31.80 | 31.80 |
| Tablet hardness (Kg) | 0.75 | 1.96 |
2. tablet friability test
Using direct Herba Dendrobii Herba Dendrobii extract to pulverize the micropowder direct compression prepared, tableting pressure is respectively at 31.80kN, respectively
Preparing 24 samples, 24 samples simultaneously using the inventive method to prepare under 31.80kN tableting pressure are surveyed as contrast
Examination.Then use CS-2 type tablet friability tester, use 25 revs/min, the above-mentioned preparation of condition test of turntable rotation 100 circle
The friability of sample, and calculate its meansigma methods for contrasting, experimental result is listed in table 8.This is can be seen that by data in table
Bright method can be greatly increased the anti-friability ability of tablet under identical film-making pressure, the tablet that commonsense method obtains via
Occurring to crack completely during friability experiment, and its friability of the inventive method is less than 0.1%, therefore, the inventive method has substantially
Improve the beneficial effect of tablet friability.
Table 8: different flaking method tablet friability comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 31.80 | 31.80 |
| Friability (%) | Fragmentation completely | <0.1 |
Embodiment 5:
The concrete preparation method of the present embodiment is as follows:
(1) fibre length is become to exist the fresh bar of defoliation Herba Dendrobii of washes clean direct attrition grinding under the conditions of 30 DEG C
Between 0.01～5000 μm, thus obtain the pureed Herba Dendrobii that water content is about 85%.
(2) the pureed Herba Dendrobii obtained is dried, under the conditions of 100 DEG C, be dried to obtain the Herba Dendrobii that water content is about 0.3%
Dry product；
(3) air-dried Dendrobium is carried out under the conditions of 30 DEG C micronizing to fine particle, obtain particle diameter in 150～300 μm
Herba Dendrobii micropowder；
(4) by compressing dry granulation, at tableting pressure at 39.75kN, Herba Dendrobii micropowder is prepared Herba Dendrobii micropowder sheet.
Sample analysis:
1. tablet hardness test
Initially with direct Herba Dendrobii Herba Dendrobii extract pulverize prepare micropowder direct compression, tableting pressure respectively at 39.75kN,
Prepare 24 samples respectively, use 24 samples that the inventive method is prepared under 39.75kN tableting pressure as right simultaneously
Than test.Then use YD-1 type tablet hardness instrument to test the hardness of sample of above-mentioned preparation, and calculate its meansigma methods for
Contrast, experimental result is listed in table 9. as can be seen from the table, and under this film-making pressure, the hardness difference of tablet is relatively big, directly
The tablet hardness that the method for tabletting is prepared only has 0.68Kg, and the relatively direct pressure of tablet hardness prepared by the inventive method
Sheet method is greatly improved, and its tablet hardness reaches 2.38Kg.Therefore, the inventive method its tablet hard when elevated pressures
Degree promotes substantially.
Table 9: different flaking method tablet hardness comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 39.75 | 39.75 |
| Tablet hardness (Kg) | 0.68 | 2.38 |
2. tablet friability test
Using direct Herba Dendrobii Herba Dendrobii extract to pulverize the micropowder direct compression prepared, tableting pressure is respectively at 39.75kN, respectively
Preparing 24 samples, 24 samples simultaneously using the inventive method to prepare under 39.75kN tableting pressure are surveyed as contrast
Examination.Then use CS-2 type tablet friability tester, use 25 revs/min, the above-mentioned preparation of condition test of turntable rotation 100 circle
The friability of sample, and calculate its meansigma methods for contrasting, experimental result is listed in table 10.This is can be seen that by data in table
Bright method can be greatly increased the anti-friability ability of tablet under identical film-making pressure, the tablet that commonsense method obtains via
Occurring to crack completely during friability experiment, and its friability of the inventive method is less than 0.1%, therefore, the inventive method has substantially
Improve the beneficial effect of tablet friability.
Table 10: different flaking method tablet friability comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 39.75 | 39.75 |
| Friability (%) | Fragmentation completely | <0.1 |
Embodiment 6:
The concrete preparation method of the present embodiment is as follows:
(1) fibre length is become to exist the fresh bar of defoliation Herba Dendrobii of washes clean direct attrition grinding under the conditions of 100 DEG C
Between 0.01～5000 μm, thus obtain the pureed Herba Dendrobii that water content is about 88%；
(2) the pureed Herba Dendrobii obtained is dried, under the conditions of 100 DEG C, be dried to obtain the Herba Dendrobii that water content is about 0.3%
Dry product；
(3) above-mentioned air-dried Dendrobium is carried out under the conditions of 100 DEG C micronizing to fine particle, obtain particle diameter 48～
106 μm Herba Dendrobii micropowder；
(4) by compressing dry granulation, at tableting pressure at 47.70kN, Herba Dendrobii micropowder is prepared Herba Dendrobii micropowder sheet.
Sample analysis:
1. tablet hardness test
Initially with direct Herba Dendrobii Herba Dendrobii extract pulverize prepare micropowder direct compression, tableting pressure respectively at 47.70kN,
Prepare 24 samples respectively, use 24 samples that the inventive method is prepared under 47.70kN tableting pressure as right simultaneously
Than test.Then use YD-1 type tablet hardness instrument to test the hardness of sample of above-mentioned preparation, and calculate its meansigma methods for
Contrast, experimental result is listed in table 11. as can be seen from the table, and under this film-making pressure, the hardness difference of tablet is relatively big, directly
Connect the tablet hardness that the method for tabletting prepares and only have 0.58Kg, and the tablet hardness prepared by the inventive method is relatively direct
Pressed disc method is greatly improved, and its tablet hardness reaches 2.86Kg.Therefore, the inventive method its tablet when elevated pressures
Hardness promotes substantially.
Table 11: different flaking method tablet hardness comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 47.70 | 47.70 |
| Tablet hardness (Kg) | 0.58 | 2.86 |
2. tablet friability test
Using direct Herba Dendrobii Herba Dendrobii extract to pulverize the micropowder direct compression prepared, tableting pressure is respectively at 47.70kN, respectively
Preparing 24 samples, 24 samples simultaneously using the inventive method to prepare under 47.70kN tableting pressure are surveyed as contrast
Examination.Then use CS-2 type tablet friability tester, use 25 revs/min, the above-mentioned preparation of condition test of turntable rotation 100 circle
The friability of sample, and calculate its meansigma methods for contrasting, experimental result is listed in table 12.This is can be seen that by data in table
Bright method can be greatly increased the anti-friability ability of tablet under identical film-making pressure, the tablet that commonsense method obtains via
Occurring to crack completely during friability experiment, and its friability of the inventive method is less than 0.1%, therefore, the inventive method has substantially
Improve the beneficial effect of tablet friability.
Table 12: different flaking method tablet friability comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 47.70 | 47.70 |
| Friability (%) | Fragmentation completely | <0.1 |
Embodiment 7:
The concrete preparation method of the present embodiment is as follows:
(1) fibre length is become to exist the fresh bar of defoliation Herba Dendrobii of washes clean direct attrition grinding under the conditions of 40 DEG C
Between 0.01～5000 μm, thus obtain the pureed Herba Dendrobii that water content is about 90%；
(2) will obtain pureed Herba Dendrobii dry, be dried to obtain under the conditions of 80 DEG C water content about 6% Herba Dendrobii do
Product；
(3) above-mentioned air-dried Dendrobium is carried out under the conditions of 40 DEG C micronizing to fine particle, obtain particle diameter 48～106
μm Herba Dendrobii micropowder；
(4) by compressing dry granulation, at tableting pressure at 55.65kN, Herba Dendrobii micropowder is prepared Herba Dendrobii micropowder sheet.
Sample analysis:
1. tablet hardness test
Initially with direct Herba Dendrobii Herba Dendrobii extract pulverize prepare micropowder direct compression, tableting pressure respectively at 55.65kN,
Prepare 24 samples respectively, use 24 samples that the inventive method is prepared under 55.65kN tableting pressure as right simultaneously
Than test.Then use YD-1 type tablet hardness instrument to test the hardness of sample of above-mentioned preparation, and calculate its meansigma methods for
Contrast, experimental result is listed in table 13. as can be seen from the table, and under this film-making pressure, the hardness difference of tablet is relatively big, directly
Connect the tablet hardness that the method for tabletting prepares and only have 0.43Kg, and the tablet hardness prepared by the inventive method is relatively direct
Pressed disc method is greatly improved, and its tablet hardness reaches 3.28Kg.Therefore, the inventive method its tablet when elevated pressures
Hardness promotes substantially.
Table 13: different flaking method tablet hardness comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 55.65 | 55.65 |
| Tablet hardness (Kg) | 0.43 | 3.28 |
2. tablet friability test
Using direct Herba Dendrobii Herba Dendrobii extract to pulverize the micropowder direct compression prepared, tableting pressure is respectively at 55.65kN, respectively
Preparing 24 samples, 24 samples simultaneously using the inventive method to prepare under 55.65kN tableting pressure are surveyed as contrast
Examination.Then use CS-2 type tablet friability tester, use 25 revs/min, the above-mentioned preparation of condition test of turntable rotation 100 circle
The friability of sample, and calculate its meansigma methods for contrasting, experimental result is listed in table 14.This is can be seen that by data in table
Bright method can be greatly increased the anti-friability ability of tablet under identical film-making pressure, the tablet that commonsense method obtains via
Occurring to crack completely during friability experiment, and its friability of the inventive method is less than 0.1%, therefore, the inventive method has substantially
Improve the beneficial effect of tablet friability.
Table 14: different flaking method tablet friability comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 55.65 | 55.65 |
| Friability (%) | Fragmentation completely | <0.1 |
Embodiment 8:
The concrete preparation method of the present embodiment is as follows:
(1) the fresh bar of defoliation Herba Dendrobii by washes clean inserts the edible ethanol attrition grinding of 10 times of fresh bar weight, by iron sheet
Herba Dendrobii fiber powder under the conditions of 0 DEG C is broken into 48～106 μm and obtains the pulpous state Herba Dendrobii that total solids content is about 6%wt；
(2) the pulpous state Herba Dendrobii drying of acquisition is obtained Herba Dendrobii soft material so that its total solids content is 40%wt；
(3), after Herba Dendrobii soft material being crossed 18-24 mesh sieve, it is dried under the conditions of 80 DEG C so that water content, 0.3%, obtains stone
Dry measure used in former times granule；
(4) at tableting pressure at about 31.8kN, Herba Dendrobii granule is prepared Herba Dendrobii micropowder sheet finished product.
Sample analysis:
1. tablet hardness test
Initially with direct Herba Dendrobii Herba Dendrobii extract pulverize prepare micropowder direct compression, tableting pressure respectively at 31.8kN,
Prepare 24 samples respectively, use 24 samples that the inventive method is prepared under 31.8kN tableting pressure as contrast simultaneously
Test.Then use the hardness of the sample of the YD-1 type tablet hardness instrument above-mentioned preparation of test, and calculate its meansigma methods for right
Ratio, experimental result is listed in table 15. as can be seen from the table, and under this film-making pressure, the hardness difference of tablet is relatively big, directly
The tablet hardness that the method for tabletting is prepared only has 0.75Kg, and the relatively direct pressure of tablet hardness prepared by the inventive method
Sheet method is greatly improved, and its tablet hardness reaches 2.01Kg.Therefore, the inventive method its tablet hard when elevated pressures
Degree promotes substantially.
Table 15: different flaking method tablet hardness comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 31.8 | 31.8 |
| Tablet hardness (Kg) | 0.75 | 2.01 |
2. tablet friability test
Using direct Herba Dendrobii Herba Dendrobii extract to pulverize the micropowder direct compression prepared, tableting pressure is respectively at 31.8kN, respectively
Preparing 24 samples, 24 samples simultaneously using the inventive method to prepare under 31.8kN tableting pressure are surveyed as contrast
Examination.Then use CS-2 type tablet friability tester, use 25 revs/min, the above-mentioned preparation of condition test of turntable rotation 100 circle
The friability of sample, and calculate its meansigma methods for contrasting, experimental result is listed in table 16.This is can be seen that by data in table
Bright method can be greatly increased the anti-friability ability of tablet under identical film-making pressure, the tablet that commonsense method obtains via
Occurring to crack completely during friability experiment, and its friability of the inventive method is less than 0.1%, therefore, the inventive method has substantially
Improve the beneficial effect of tablet friability.
Table 16: different flaking method tablet friability comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 31.8 | 31.8 |
| Friability (%) | Fragmentation completely | <0.1 |
Embodiment 9:
The concrete preparation method of the present embodiment is as follows:
(1): the fresh bar of defoliation Herba Dendrobii of washes clean is inserted the deionized water of 20 times of fresh bar weight and pulverizes under the conditions of 3 DEG C
Grind, Herba Dendrobii fiber powder is broken into 75～150 μm and obtains the pulpous state Herba Dendrobii that water content is about 4%wt；
(2) the pulpous state Herba Dendrobii drying of acquisition is obtained Herba Dendrobii soft material so that its total moisture content is 93%；
(3), after Herba Dendrobii soft material being crossed 18～24 mesh sieves, it is dried under the conditions of 100 DEG C so that water content, 0.5%, obtains
Herba Dendrobii granule；
(4) tabletting: at tableting pressure between 31.8kN, prepares Herba Dendrobii micropowder sheet finished product by Herba Dendrobii granule.
Sample analysis:
1. tablet hardness test
Initially with direct Herba Dendrobii Herba Dendrobii extract pulverize prepare micropowder direct compression, tableting pressure respectively at 31.8kN,
Prepare 24 samples respectively, use 24 samples that the inventive method is prepared under 31.8kN tableting pressure as contrast simultaneously
Test.Then use the hardness of the sample of the YD-1 type tablet hardness instrument above-mentioned preparation of test, and calculate its meansigma methods for right
Ratio, experimental result is listed in table 17. as can be seen from the table, and under this film-making pressure, the hardness difference of tablet is relatively big, directly
The tablet hardness that the method for tabletting is prepared only has 0.75Kg, and the relatively direct pressure of tablet hardness prepared by the inventive method
Sheet method is greatly improved, and its tablet hardness reaches 2.11Kg.Therefore, the inventive method its tablet hard when elevated pressures
Degree promotes substantially.
Table 17: different flaking method tablet hardness comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 31.8 | 31.8 |
| Tablet hardness (Kg) | 0.75 | 2.11 |
2. tablet friability test
Using direct Herba Dendrobii Herba Dendrobii extract to pulverize the micropowder direct compression prepared, tableting pressure is respectively at 31.8kN, respectively
Preparing 24 samples, 24 samples simultaneously using the inventive method to prepare under 31.8kN tableting pressure are surveyed as contrast
Examination.Then use CS-2 type tablet friability tester, use 25 revs/min, the above-mentioned preparation of condition test of turntable rotation 100 circle
The friability of sample, and calculate its meansigma methods for contrasting, experimental result is listed in table 18.This is can be seen that by data in table
Bright method can be greatly increased the anti-friability ability of tablet under identical film-making pressure, the tablet that commonsense method obtains via
Occurring to crack completely during friability experiment, and its friability of the inventive method is less than 0.1%, therefore, the inventive method has substantially
Improve the beneficial effect of tablet friability.
Table 18: different flaking method tablet friability comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 31.8 | 31.8 |
| Friability (%) | Fragmentation completely | <0.1 |
Embodiment 10:
The concrete preparation method of the present embodiment is as follows:
(1) being squeezed the juice by the fresh bar of defoliation Herba Dendrobii of washes clean, separate liquid and fiber part, obtaining water content is 5% left side
Right fiber, then by fiber micronizing under the conditions of-20 DEG C, obtains fiber size powder between 0.01～1.3 μm；
(2) juice and fiber dust step (1) obtained uniformly mixes, and is dried under the conditions of 100 DEG C so that dried
The water content of the air-dried Dendrobium obtained is 0.3%wt；
(3) at tableting pressure 23.8kN, granule compacting is obtained Herba Dendrobii sheet finished product.
Sample analysis:
1. tablet hardness test
Initially with direct Herba Dendrobii Herba Dendrobii extract pulverize prepare micropowder direct compression, tableting pressure respectively at 23.8kN,
Prepare 24 samples respectively, use 24 samples that the inventive method is prepared under 23.8kN tableting pressure as contrast simultaneously
Test.Then use the hardness of the sample of the YD-1 type tablet hardness instrument above-mentioned preparation of test, and calculate its meansigma methods for right
Ratio, experimental result is listed in table 19. as can be seen from the table, and under this film-making pressure, the hardness difference of tablet is relatively big, directly
The tablet hardness that the method for tabletting is prepared only has 0.8Kg, and the relatively direct pressure of tablet hardness prepared by the inventive method
Sheet method is greatly improved, and its tablet hardness reaches 3.10Kg.Therefore, the inventive method its tablet hard when elevated pressures
Degree promotes substantially.
Table 19: different flaking method tablet hardness comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 23.8 | 23.8 |
| Tablet hardness (Kg) | 0.80 | 3.10 |
2. tablet friability test
Using direct Herba Dendrobii Herba Dendrobii extract to pulverize the micropowder direct compression prepared, tableting pressure is respectively at 23.8kN, respectively
Preparing 24 samples, 24 samples simultaneously using the inventive method to prepare under 23.8kN tableting pressure are surveyed as contrast
Examination.Then use CS-2 type tablet friability tester, use 25 revs/min, the above-mentioned preparation of condition test of turntable rotation 100 circle
The friability of sample, and calculate its meansigma methods for contrasting, experimental result is listed in table 20.This is can be seen that by data in table
Bright method can be greatly increased the anti-friability ability of tablet under identical film-making pressure, the tablet that commonsense method obtains via
Occurring to crack completely during friability experiment, and its friability of the inventive method is less than 0.1%, therefore, the inventive method has substantially
Improve the beneficial effect of tablet friability.
Table 20: different flaking method tablet friability comparing results
| Direct compression | The inventive method | |
| Tableting pressure (kN) | 23.8 | 23.8 |
| Friability (%) | Fragmentation completely | <0.1 |
With the above-mentioned desirable embodiment according to the present invention for enlightenment, by above-mentioned description, relevant staff is complete
Entirely can carry out various change and amendment in the range of without departing from this invention technological thought.The technology of this invention
The content that property scope is not limited in description, it is necessary to determine its technical scope according to right.
Claims (10)
1. a Herba Dendrobii micropowder sheet, it is characterised in that described Herba Dendrobii micropowder sheet exists at 0.1 ~ 25%wt, particle diameter only with water content
The Herba Dendrobii micropowder of 0.01 ~ 300 μm is prepared.
2. the method preparing Herba Dendrobii micropowder sheet as claimed in claim 1, it is characterised in that comprise the following steps:
(1) by the fresh bar of defoliation Herba Dendrobii of washes clean direct attrition grinding under the conditions of-80 ~ 120 DEG C, obtain fiber size and exist
The pureed Herba Dendrobii of 0.01 ~ 5000 μm, the moisture of pureed Herba Dendrobii is 40 ~ 93%；
(2) the pureed Herba Dendrobii that drying steps (1) obtains under the conditions of 30 ~ 250 DEG C so that containing of the air-dried Dendrobium obtained after drying
The water yield is 0.1 ~ 25% wt；
(3) above-mentioned dry product is pulverized again, obtain particle diameter at 0.01 ~ 300 μm Herba Dendrobii micropowder；
(4) by compressing dry granulation, at tableting pressure between 3.18 ~ 55.7kN, Herba Dendrobii micropowder is prepared Herba Dendrobii micropowder sheet finished product.
3. the method preparing Herba Dendrobii micropowder sheet as claimed in claim 1, it is characterised in that comprise the following steps:
(1) after adding appropriate solvent in the fresh bar of defoliation Herba Dendrobii of washes clean by fresh for Herba Dendrobii bar under the conditions of-80 ~ 120 DEG C
It is directly ground to the pulpous state Herba Dendrobii obtaining fiber grain size in 0.01 ~ 300 μm, total solids content in described pulpous state Herba Dendrobii≤
7%wt；
(2) the pulpous state Herba Dendrobii drying of acquisition is obtained the total solids content pureed Herba Dendrobii at 7 ~ 60%wt；
(3) being pelletized by dry or wet by the pureed Herba Dendrobii that step (2) obtains, tabletting prepares Herba Dendrobii micropowder sheet.
The method preparing Herba Dendrobii micropowder sheet the most as claimed in claim 3, it is characterised in that described wet granulation includes walking as follows
Rapid:
A., after pureed Herba Dendrobii being crossed 18-24 mesh sieve, it is dried under the conditions of 30 ~ 250 DEG C so that total solids content is 75 ~ 99.9%
The air-dried Dendrobium of wt, obtains granule；
B., between tableting pressure 3.18 ~ 55.7kN, granule compacting is obtained Herba Dendrobii micropowder sheet finished product.
The method preparing Herba Dendrobii micropowder sheet the most as claimed in claim 3, it is characterised in that described dry granulation includes walking as follows
Rapid:
A. under the conditions of 30 ~ 250 DEG C, pureed Herba Dendrobii it is dried so that the water content of the air-dried Dendrobium obtained after drying is 0.1 ~ 25%
wt；
B. by compressing dry granulation, at tableting pressure between 3.18 ~ 55.7kN, air-dried Dendrobium is made Herba Dendrobii micropowder sheet finished product.
The method preparing Herba Dendrobii micropowder sheet the most according to claim 3, it is characterised in that: described solvent is water, propanol, lemon
Lemon triethylenetetraminehexaacetic acid ester, propylene glycol, ethanol, methanol, acetone, sec-butyl alcohol, 1,3 butylene glycol, acetum, thiacyclohexane, dichloromethane,
Ether, diethyl tartrate., dichloroethanes, diacetine, an acetin, hexane, isopropanol, nutmeg acid isopropyl
One or many in ester, petroleum ether, nitropropane, toluene, trichloro ethylene, trichorotrifluoroethane, alkanes or No. six light gasoline
Kind；Adding of described solvent is of low quality in 20 times of defoliation Herba Dendrobii fresh bar quality.
7. the method preparing Herba Dendrobii micropowder sheet as claimed in claim 1, it is characterised in that comprise the following steps:
(1) washes clean, water content are squeezed the juice at the fresh bar of defoliation Herba Dendrobii of 40 ~ 93%wt, be directly separated or pass through centrate
Body and fiber part, then by fiber attrition grinding under the conditions of-80 ~ 120 DEG C, obtain fiber size between 0.01 ~ 300 μm
Powder；
(2) juice and fiber dust step (1) obtained uniformly mixes, and is dried under the conditions of 30 ~ 250 DEG C so that dried
The water content of the air-dried Dendrobium obtained is 0.1 ~ 25% wt；
(3) between tableting pressure 3.18 ~ 55.7kN, granule compacting is obtained Herba Dendrobii sheet finished product.
8. according to the method preparing Herba Dendrobii micropowder sheet described in any one of claim 2 ~ 7, it is characterised in that: described Herba Dendrobii is fresh
Bar refers to Herba Dendrobii, Herba Dendrobii, Dendrobium nobile, dendrobium moniliformeSweet, Dendrobium loddigesii, Dendrobium chrysanthum, Herba Dendrobii, Mi Huashi
Dry measure used in former times, Dendrobium fimbriatum Hook., Dendrobium thyrsiflorum, Dendrobium devonianum Part., Dendrobium chrysotoxum, weight lip Herba Dendrobii, Dendrobium flexicaule, little Dendrobium tosaense Makino, comb lip Herba Dendrobii,
Hide south Herba Dendrobii, Dendrobium crepidatum lindl et paxt．, brilliant cap Herba Dendrobii, Dendrobium aphyllum (Roxb.) C. E. Fisch．, cup sheath Herba Dendrobii, dendrobium hancockii Rolfe, Dendrobium falconeri Hook．, Dendrobium henryi Schltr. or luxuriant greatly
The fresh bar of sheath Herba Dendrobii.
The method preparing Herba Dendrobii micropowder sheet the most according to claim 2, it is characterised in that: in described step (2), Herba Dendrobii is done
The water content of product is 0.1 ~ 10% wt.
The method preparing Herba Dendrobii micropowder sheet the most according to claim 3, it is characterised in that: in described step (3), Herba Dendrobii is done
The total solids content of product is at 90 ~ 99.9%wt.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108669531A (en) * | 2018-03-29 | 2018-10-19 | 遵义医学院 | A kind of HERBA DENDROBII powder and its application |
| CN113181132A (en) * | 2021-04-27 | 2021-07-30 | 宁波西敦医药包衣科技有限公司 | Chinese herbal medicine superfine powder composition, preparation method and application of Chinese herbal medicine superfine powder tablet |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961561A (en) * | 2014-05-26 | 2014-08-06 | 浙江万邦药业股份有限公司 | Dendrobe summer-heat relieving healthy product composition and preparation method thereof |
| CN104189502A (en) * | 2014-08-13 | 2014-12-10 | 山东东阿阿胶股份有限公司 | Micronized dendrobium officinale tablet and preparation method thereof |
-
2016
- 2016-08-23 CN CN201610710364.8A patent/CN106266609A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961561A (en) * | 2014-05-26 | 2014-08-06 | 浙江万邦药业股份有限公司 | Dendrobe summer-heat relieving healthy product composition and preparation method thereof |
| CN104189502A (en) * | 2014-08-13 | 2014-12-10 | 山东东阿阿胶股份有限公司 | Micronized dendrobium officinale tablet and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 中国食品工业协会营养指导工作委员会等: "《公共营养师培训教材》", 31 July 2011, 军事医学科学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108669531A (en) * | 2018-03-29 | 2018-10-19 | 遵义医学院 | A kind of HERBA DENDROBII powder and its application |
| CN113181132A (en) * | 2021-04-27 | 2021-07-30 | 宁波西敦医药包衣科技有限公司 | Chinese herbal medicine superfine powder composition, preparation method and application of Chinese herbal medicine superfine powder tablet |
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Application publication date: 20170104 |