CN106266023B - Medicine for treating gastric ulcer and preparation method thereof - Google Patents

Medicine for treating gastric ulcer and preparation method thereof Download PDF

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CN106266023B
CN106266023B CN201610785268.XA CN201610785268A CN106266023B CN 106266023 B CN106266023 B CN 106266023B CN 201610785268 A CN201610785268 A CN 201610785268A CN 106266023 B CN106266023 B CN 106266023B
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gastric ulcer
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CN106266023A (en
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彭舒怀
王林
易志红
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Da Jia Wei Kang Biopharmaceutical Co.,Ltd.
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Hunan Kaang'er Pharmaceutical Ltd By Share Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K2236/30—Extraction of the material
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Abstract

The invention relates to a medicine for treating gastric ulcer and a preparation method thereof. The invention provides a medicine for treating gastric ulcer, which comprises the following components in parts by weight: 30-45 parts of clove oil, 15-25 parts of chitosan, 28-36 parts of concha arcae, 40-60 parts of egg shell, 28-38 parts of dried alum, 2-4 parts of rhodiola rosea, 25-35 parts of fructus polygoni orientalis, 0.2-0.6 part of pearl powder and 120 parts of hairyvein agrimony. The medicine for treating gastric ulcer provided by the invention has the advantages that various components are safe and mild, the retention time of the medicine in the stomach can be effectively prolonged, the effects of nourishing and protecting the stomach are achieved, the ulcer part is sterilized and protected, and the gastric ulcer can be radically treated after long-term administration.

Description

Medicine for treating gastric ulcer and preparation method thereof
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a medicine for treating gastric ulcer and a preparation method thereof.
background
Gastric ulcer or peptic ulcer is a common disease of the digestive tract, and can occur in the esophagus, the stomach or the duodenum, and also in the vicinity of the gastrojejunostomy or in a Meckel diverticulum containing the gastric mucosa, and is generally referred to as gastric ulcer and duodenal ulcer because gastric ulcer and duodenal ulcer are most common. It is called peptic ulcer because it has been considered that gastric ulcer and duodenal ulcer are formed by the self-digestion of mucous membrane by gastric acid and pepsin, and in fact gastric acid and pepsin are only one of the main causes of ulcer formation, and there are other causes that can form peptic ulcer. Since there are many similarities in the etiology and clinical symptoms of gastric ulcer and duodenal ulcer, it is sometimes difficult to distinguish between gastric ulcer and duodenal ulcer, and thus peptic ulcer, or gastric, duodenal ulcer, is often diagnosed.
The existing medicine for treating gastric ulcer is mainly used for neutralizing gastric acid through calcium-containing raw materials, the method is actually used for relieving the erosion of gastric acid to wounds, but is not a permanent cure method, and for patients, the original condition can be recovered after the medicine is stopped taking the medicine, and particularly for patients with chronic gastric ulcer, the phenomenon is obvious.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a medicine for treating gastric ulcer, which can nourish and protect the stomach and eradicate patients, and a preparation method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
The invention provides a medicine for treating gastric ulcer, which comprises the following components in parts by weight: 30-45 parts of clove oil, 15-25 parts of chitosan, 28-36 parts of concha arcae, 40-60 parts of egg shell, 28-38 parts of dried alum, 2-4 parts of rhodiola rosea, 25-35 parts of fructus polygoni orientalis, 0.2-0.6 part of pearl powder and 120 parts of hairyvein agrimony.
The medicine prepared by the formula has better curative effect on acute gastric ulcer or chronic gastric ulcer, is particularly suitable for treating the chronic gastric ulcer, and is found to be suitable for long-term administration of patients through long-term clinical tests and can radically treat the gastric ulcer.
Preferably, the medicine for treating gastric ulcer comprises the following components in parts by weight: 35-45 parts of clove oil, 15-20 parts of chitosan, 30-35 parts of concha arcae, 45-55 parts of egg shell, 30-35 parts of dried alum, 2-4 parts of rhodiola rosea, 30-35 parts of fructus polygoni orientalis, 0.3-0.6 part of pearl powder and 115 parts of hairyvein agrimony 110-.
Further preferably, the medicine for treating gastric ulcer comprises the following components in parts by weight: 40 parts of clove oil, 16 parts of chitosan, 32 parts of concha arcae, 48 parts of egg shell, 32 parts of dried alum, 3 parts of rhodiola rosea, 32 parts of fructus polygoni orientalis, 0.5 part of pearl powder and 112 parts of hairyvein agrimony.
Preferably, the chitosan in the drug for treating gastric ulcer has a deacetylation degree of 70-90% and a molecular weight of 80000-100000.
Preferably, the medicine for treating gastric ulcer further comprises 5-10 parts of honey. The honey is fructose extracted from honey, the taste of the honey is mild, the honey is used as a sweetening agent, the functions of reducing blood pressure, protecting liver, relieving pain and the like are achieved, the honey can be matched with the medicines to enhance the drug effect, and the function of protecting stomach is achieved.
Preferably, the components of the medicament for treating the gastric ulcer are 200-400-mesh powder.
preferably, the components in the medicine for treating gastric ulcer are 400-mesh powder.
The preparation method of the medicine for treating gastric ulcer comprises the following steps:
A. Preparing the hairyvein agrimony clear paste: decocting herba et Gemma Agrimoniae in water twice for 2-3 hr each time, mixing decoctions, filtering, standing for 24 hr, and concentrating the supernatant to obtain fluid extract with relative density of 80-85 deg.C and relative density of 1.18-1.20;
B. preparing a capsule: mixing chitosan, Concha arcae, ovum gallus domesticus crusta, dried Alumen, radix Rhodiolae, and fructus Polygoni orientalis with the fluid extract, granulating, drying to obtain granules, encapsulating, and adding oleum Caryophylli into the capsule to obtain the final product.
Preferably, in the preparation method of the medicine for treating gastric ulcer, the clove oil in the step B is added into the capsule, and then the honey is added into the capsule to obtain the product.
preferably, the temperature for drying into granules in step B in the preparation method of the medicine for treating gastric ulcer is not higher than 60 ℃.
In conclusion, the medicine for treating gastric ulcer provided by the invention has the advantages that various components are safe and mild, the retention time of the medicine in the stomach can be effectively prolonged, the effects of nourishing and protecting the stomach are achieved, the ulcer part is sterilized and protected, and the gastric ulcer can be radically treated after long-term administration.
Detailed Description
The present invention is further illustrated by the following specific examples. The described embodiments are only preferred embodiments of the present invention and are not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
example one
Decocting 112g herba et Gemma Agrimoniae with water twice, each for 2 hr, mixing decoctions, filtering, standing for 24 hr, and concentrating the supernatant to fluid extract with relative density of 80-85 deg.C and relative density of 1.18-1.20;
The following components which are crushed into 400 meshes in advance are added with clear paste to be evenly mixed and granulated: 16g of chitosan with deacetylation degree of 70% and molecular weight of 80000, 32g of concha arcae, 48g of eggshell, 32g of dried alum, 3g of rhodiola rosea and 32g of fructus polygoni orientalis, drying into granules, filling into capsules, adding clove oil into the capsules, and finally adding honey into the capsules to obtain the product. The clove oil is 40g in total, the honey is 10g in total, and finally, capsules are prepared and filled according to the proportion, wherein each capsule contains 0.5g of the composition.
Example two
Decocting 120g herba et Gemma Agrimoniae with water twice, each for 2.5 hr, mixing decoctions, filtering, standing for 24 hr, and concentrating the supernatant to fluid extract with relative density of 80-85 deg.C and temperature of 1.18-1.20;
The following components which are crushed into 300 meshes in advance are added with clear paste to be mixed evenly and granulated: 25g of chitosan with deacetylation degree of 80% and molecular weight of 90000, 36g of concha arcae, 60g of eggshell, 38g of dried alum, 4g of rhodiola rosea and 25g of fructus polygoni orientalis, drying into granules, filling into capsules, adding clove oil into the capsules, and finally adding honey into the capsules to obtain the product. The clove oil is 30g in total, the honey is 5g in total, and finally, capsules are prepared and filled according to the proportion, wherein each capsule contains 0.5g of the composition.
EXAMPLE III
Decocting 100g herba et Gemma Agrimoniae in water twice, each for 3 hr, mixing decoctions, filtering, standing for 24 hr, and concentrating the supernatant to fluid extract with relative density of 80-85 deg.C and relative temperature of 1.18-1.20;
The following components which are crushed into 200 meshes in advance are added with clear paste to be mixed evenly and granulated: 15g of chitosan with deacetylation degree of 70% and molecular weight of 100000, 28g of concha arcae, 40g of egg shell, 28g of dried alum, 2g of rhodiola rosea and 35g of fructus polygoni orientalis, drying into granules, filling into capsules, and adding clove oil into the capsules to obtain the product. The total amount of the clove oil is 45g, and finally capsules are prepared and filled in proportion, wherein each capsule contains 0.5g of the composition.
example four
decocting 115g herba et Gemma Agrimoniae with water twice (2 hr for the first time and 3 hr for the second time), mixing decoctions, filtering, standing the filtrate for 24 hr, and concentrating the supernatant to fluid extract with relative density of 80-85 deg.C of 1.18-1.20;
The following components which are crushed into 400 meshes in advance are added with clear paste to be evenly mixed and granulated: 20g of chitosan with deacetylation degree of 90% and molecular weight of 80000, 30g of concha arcae, 45g of eggshell, 30g of dried alum, 4g of rhodiola rosea and 35g of fructus polygoni orientalis, drying into granules, filling into capsules, and adding clove oil into the capsules to obtain the product. The total amount of the clove oil is 35g, and finally capsules are prepared and filled in proportion, wherein each capsule contains 0.5g of the composition.
Examples one to four capsules prepared were administered orally to patients 1 at a time 3 times a day. The total 76 people are 25-73 years old, and 62 of them are patients with chronic gastric ulcer, and the rest are patients with acute gastric ulcer caused by taking other stimulating medicines.
The clinical results were: after the chronic gastric ulcer patients take the medicine for two months, the ulcer symptoms are obviously relieved, after the medicine is taken for one year, the gastric ulcer of 16 patients does not relapse after the medicine is stopped for one and a half years, and after the medicine is taken for one and a half years, the gastric ulcer of 32 patients does not relapse after the medicine is stopped for one and a half years. After the patient with acute gastric ulcer takes the medicine for 15 days, the patient can get better, and the patient can be basically cured after taking the medicine for one week.

Claims (2)

1. A preparation method of a medicine for treating gastric ulcer is characterized by comprising the following steps: the medicine for treating gastric ulcer comprises the following components in parts by weight: 35-45 parts of clove oil, 15-20 parts of chitosan, 30-35 parts of concha arcae, 45-55 parts of egg shell, 30-35 parts of dried alum, 2-4 parts of rhodiola rosea, 30-35 parts of fructus polygoni orientalis, 0.3-0.6 part of pearl powder and 115 parts of hairyvein agrimony 110-containing material; also comprises 5-10 parts of honey; the deacetylation degree of the chitosan is 70-90%, and the molecular weight is 80000-100000; the components are 400-mesh powder;
The preparation method of the medicine for treating gastric ulcer comprises the following steps:
A. preparing the hairyvein agrimony clear paste: decocting herba et Gemma Agrimoniae in water twice for 2-3 hr each time, mixing decoctions, filtering, standing for 24 hr, and concentrating the supernatant to obtain fluid extract with relative density of 80-85 deg.C and relative density of 1.18-1.20;
B. preparing a capsule: mixing chitosan, Concha arcae, ovum gallus domesticus crusta, dried Alumen, radix Rhodiolae, and fructus Polygoni orientalis with the fluid extract, granulating, drying to obtain granules, encapsulating, and adding oleum Caryophylli into the capsule to obtain the final product;
Adding the clove oil into the capsule in the step B, and then adding the honey into the capsule to obtain a product;
the temperature for drying into particles in the step B is not higher than 60 ℃.
2. a medicament for the treatment of gastric ulcer prepared by the process according to claim 1.
CN201610785268.XA 2016-08-31 2016-08-31 Medicine for treating gastric ulcer and preparation method thereof Active CN106266023B (en)

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CN117618377A (en) * 2023-11-23 2024-03-01 海南锦麟医药科技有限公司 Ulcer capsule and application thereof in preparation of medicament for promoting regeneration of damaged skin surface

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紫锥菊多酚植物化学物质对大鼠应激性胃溃疡的影响;曹鑫、张宇等;《大连医科大学学报》;20090831;第31卷(第4期);第283-290页 *

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