CN106265931A - Treat Chinese medicine composition of rheumatism, gout and preparation method thereof - Google Patents
Treat Chinese medicine composition of rheumatism, gout and preparation method thereof Download PDFInfo
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- CN106265931A CN106265931A CN201610795530.9A CN201610795530A CN106265931A CN 106265931 A CN106265931 A CN 106265931A CN 201610795530 A CN201610795530 A CN 201610795530A CN 106265931 A CN106265931 A CN 106265931A
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- gout
- ethanol
- chinese medicine
- caprae seu
- seu ovis
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to a kind of Chinese medicine composition treating rheumatism, gout and preparation method thereof, with ground Os Caprae seu Ovis, Herba Siegesbeckiae, Radix Stephaniae Tetrandrae, Flos Carthami, Cortex erythrinae and Caulis Spatholobi etc. as raw material, difference according to feedstock property, ground Os Caprae seu Ovis and other raw materials are separately processed, first the raw material in addition to ground Os Caprae seu Ovis is washed after ethanol extracts, the method of fractional distillation again, obtains intermediate products I；Again by after ground Os Caprae seu Ovis boiling, the method extracting fractional distillation again with ethanol, obtain intermediate products II, finally mixing adds benzoic acid and obtains finished product.The invention have the benefit that the treatment rheumatism of the present invention, the Chinese medicine composition of gout cure mainly rheumatism, rheumatoid, gout, rheumatic heart disease, rheumatic arthritis, sciatica, scapulohumeral periarthritis；Rheumatoid, gout there is specially good effect.The finished product prepared has effect of blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, alleviating pain and detumescence；The diseases such as rheumatism, rheumatoid and gout are had effective fast, curative effect high, safety and toleration all preferably feature.
Description
Technical field
The invention belongs to a kind of processing technique of Chinese herbs field, be specifically related to a kind of Chinese medicine composition treating rheumatism, gout
And preparation method thereof.
Background technology
People lives in the Nature, and a lot of people inevitably bear rheumatic ostalgia, the misery that gout is brought.At present,
At home, be directed to the disease such as gout, rheumatism also not the most medicable medicine, the means for the treatment of be mostly medicated wine or
Plaster for rheumatism and ostealiga, has had hundreds of Chinese medicine composition mix proportion scheme to be made known publicly.Such as, " the medicated wine of a kind of antirheumatic
And preparation method thereof " (Application No. CN101301449) be with Radix Saposhnikoviae, Rhizoma Polygonati, Fructus Tribuli, Semen Abutili seed, Rhizoma Kaempferiae as adjuvant, adds green grass or young crops
Highland barley, distillers yeast, spring water through boiling, ferment, distill the common brew of technique and form the medicated wine of antirheumatic；" a kind of old cream of rheumatism
Medicine and using method thereof " (Application No. CN201410336633) mainly take Herba speranskiae tuberculatae, Radix Clematidis, Semen Impatientis, stir-baked SQUAMA MANITIS, river
Green pepper, Cortex erythrinae, Flos Carthami, Herba Lycopodii, Rhizoma Drynariae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Herba Schizonepetae, Radix Aconiti, Radix Aconiti Kusnezoffii, Semen Strychni, Radix Aconiti Lateralis Preparata, Folium Artemisiae Argyi,
Each 120 parts of Herba Lycopodii, Herba Asari, fines medicine: each 100 parts of Olibanum, Myrrha, Camphora, Borneolum Syntheticum, Sanguis Draxonis, 5000 parts of Oleum Sesami, Plumbum preparatium
2500-2600 part, according to immersing diel in Oleum Sesami after the raw material of each weight portion and the mixing of fines medicine, then frying to the most withered and the most yellow also
Lower Plumbum preparatium, stirring is brewed into plaster, finally directly against overlaying at sufferer；" " Xiaofengtong " injection and preparation method thereof " (application number
For CN1098648) provide a kind of " Xiaofengtong " injection and preparation method thereof, with Herba Siegesbeckiae, Caulis Spatholobi, Radix Stephaniae Tetrandrae, Radix Angelicae Dahuricae (Radix Heraclei Scabridi), pittosporum tobira
Skin, Rhizoma Cibotii, Caulis Trachelospermi, Os Canitis are raw material, and Os Canitis is through decocting in water, ethanol leaching, and other raw mixture in addition to Os Canitis is through water
Leaching, ethanol leaching, evaporate ethanol after mixing, dilution obtains " Xiaofengtong " injection.
Although gout and rheumatism both diseases all can cause arthralgia, but rheumatism is mainly knee joint, shoulder joint
The big arthralgia such as joint, waist, contacts substantially with Changes in weather, and it is higher that Clinical Laboratory shows as rheumatism index, and erythrocyte sedimentation rate is high；Gout is then
Showing as big toe pain, often show effect at midnight, foot does not lands, and typically there will be red and swollen heat pain, does not has the biggest connection with weather
System, it is high that Clinical Laboratory shows as serum Uric Acid Concentration.Rheumatism is referred to as arthralgia due to cold in the traditional Chinese medical science, is owing to wind, cold, wet three heresy integrates
Body, affects QI and blood unobstructed, causes pain.Gout is then belonging to metabolic disease, mainly purine metabolic disturbance, damp and hot retardance
Meridians cause arthralgia, mainly show as red and swollen heat pain, in the majority with male patient.So, arthralgia is considered the most simply
Owing to rheumatism causes, this is mistake and adventurous, and this pain Health Killer behind that is hidden in of gout can be made to be left in the basket.
China and foreign countries enjoyed great prestige by traditional famous medicine tiger-bone medicated wine of China, and it has preferable curative effect to gout and rheumatism, but tiger is state
The wild animal being on the brink of extinction is laid special stress on protecting, according to country's conservation of wildlife implementing regulations and endangered species of wild fauna and flora kind on border
International trade pact forbids Os Tigris trade, cancels Os Tigris medicinal standard, and must not use Os Tigris pharmacy again, also forbids tiger-bone medicated wine to buy
Sell.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of Chinese drug-treated group treating rheumatism, gout
Compound and preparation method thereof, the finished product prepared cures mainly rheumatism, rheumatoid, gout, rheumatic heart disease, rheumatic arthritis, sciatic nerve
Bitterly, scapulohumeral periarthritis.
The technical solution adopted in the present invention is: a kind of Chinese medicine composition treating rheumatism, gout, including following weight portion
Raw material: ground Os Caprae seu Ovis 4-6 part, Herba Siegesbeckiae 2-4 part, Radix Stephaniae Tetrandrae 1-2 part, Flos Carthami 2-4 part, Cortex erythrinae 1-2 part, Caulis Spatholobi 2-4 part.
As a further improvement on the present invention, including the raw material of following weight portion: ground Os Caprae seu Ovis 4-6 part, Herba Siegesbeckiae 2-4 part,
Radix Stephaniae Tetrandrae 1-2 part, Flos Carthami 2-4 part, Cortex erythrinae 1-2 part, Caulis Spatholobi 2-4 part, Caulis Trachelospermi 2-3 part, Radix Saposhnikoviae 1-2 part.
As a further improvement on the present invention, including the raw material of following weight portion: ground Os Caprae seu Ovis 4-6 part, Herba Siegesbeckiae 2-4 part,
Radix Stephaniae Tetrandrae 1-2 part, Flos Carthami 2-4 part, Cortex erythrinae 1-2 part, Caulis Spatholobi 2-4 part, Caulis Trachelospermi 2-3 part, Radix Saposhnikoviae 1-2 part, Cortex Eucommiae 2-4 part,
Radix Gentianae Marcrophyllae 1-2 part.
Treatment rheumatism described in a kind of, the preparation method of the Chinese medicine composition of gout, comprise the following steps:
(1) compound extraction: being mixed in proportion by all raw materials in addition to ground Os Caprae seu Ovis, mix homogeneously obtains compound, to
Adding the ethanol that concentration is 80-96% in described compound and carry out extraction 7-15 days, feed liquid separates, after obtaining lixiviating solution and extraction
Compound；Compound after described extraction adds water, washs 2-3 time, collect each cleaning mixture, be mixed to get
Mixing, washing liquid；Described lixiviating solution and described mixing, washing liquid being mixed, mix homogeneously obtains mixed liquor, then to described
Mixed liquor carries out fractional distillation, discards ethanol and ethanol boiling point with purgation fraction, collects the fraction that ethanol boiling point is with less than up to 97 DEG C,
Obtain intermediate products I；
(2) process of Os Caprae seu Ovis: ground Os Caprae seu Ovis is smashed, add water boiling several times, discard ground Os Caprae seu Ovis, collect each decocting in water
Liquid obtains mixing water cooking liquid, and adding concentration in described mixing water cooking liquid is the ethanol of 80-96%, and mix homogeneously obtains material liquid；
Described material liquid was stood after 7-15 days and carries out fractional distillation, discard ethanol and ethanol boiling point with purgation fraction, collect ethanol boiling point with
The fraction of up to less than 97 DEG C, obtains intermediate products II；
(3) mixing: described intermediate products I and described intermediate products II are mixed, carries out sterilizing i.e. after mix homogeneously
Obtain finished product.
As a further improvement on the present invention, lixiviating solution described in step (1) with the volume ratio of described mixing, washing liquid is
1:4-6。
As a further improvement on the present invention, the addition of ethanol described in step (1) was not for have described compound 1-
2cm。
As a further improvement on the present invention, the quality of step (1) described compound and the volume ratio of described intermediate products I
It it is 1 gram: 2-3 milliliter.
As a further improvement on the present invention, ground quality and described intermediate products II volume of Os Caprae seu Ovis described in step (2)
Ratio is 1 gram: 2-3 milliliter.
As a further improvement on the present invention, the addition of ethanol described in step (2) is the 1/ of described water cooking liquid weight
3-1/2。
As a further improvement on the present invention, described in step (2), the temperature of boiling is 85-95 DEG C, described boiling time
Number is 3 times, and the time of each described boiling is 1-2 hour.
As a further improvement on the present invention, the backward described finished product of step (3) adds benzyl alcohol, described benzoic add
Enter the 0.01-0.5% that amount is described finished weight.Benzyl alcohol plays the effect of pain relieving.
The finished product of the present invention directly can use as injection, uses injection, taking dose a: shot four milliliters.
Hereinafter, character etc. raw materials used in the present invention is described further:
Ground Os Caprae seu Ovis derives from the zokor of Rodentia Cricetidae, is the Ideal Substitute of Chinese medicine treasure Os Tigris.Acrid in the mouth, sweet, property
Cold；Return liver, stomach warp；There are the effects such as heat-clearing and toxic substances removing, dispersing cold for relieving pain, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgesic, strengthening the tendons and bones；Can be used for epidemic febrile disease,
Heresy enters nutrient blood, hyperpyrexia, and macule is indistinct, or controls lupus erythematosus, and weakness of the spleen and stomach is received and transported mistake department, and distension and fullness in the abdomen, big loose stool is thin.
Herba Siegesbeckiae: bitter in the mouth, pungent, cold in nature；Return liver, kidney channel；There is wind-damp dispelling, the meridian dredging, effect of heat-clearing and toxic substances removing；For wind
Pain of dampness syndrome, stiffness of the muscle and joint, weakness of the waist and knees, hemiplegia, hypertension, malaria, jaundice, carbuncle, sore, rubella eczema, worm beast
Bite.
Cortex erythrinae, for Araliaceae wood peel of stem or stem, have another name called magpie do not step on, tiger sun thorn, Cortex erythrinae, HUANGLONG bud, sting
Cypress etc., root bark tubular or lamellar.Acrid in the mouth, hardship, property is put down；Return liver, stomach, kidney channel；Expelling wind and removing dampness, diuretic and in, promoting blood circulation and detoxication；Main
Dispelling the wind and dampness pathogens arthralgia, waist and leg ache, edema due to deficiency of the kidney, quench one's thirst, gastric abscess, traumatic injury, fracture, spit blood, epistaxis, malaria, dermatitis rhus,
Osteomyelitis, deep pus infections.
In the present invention Os Caprae seu Ovis be monarch drug, slightly warm in nature, have the merits such as dispersing cold for relieving pain, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgesic, strengthening the tendons and bones
Effect；Herba Siegesbeckiae cold-dispelling, the meridian dredging, heat-clearing and toxic substances removing, have antiinflammatory, blood pressure lowering and expand blood vessel, malaria；Radix Stephaniae Tetrandrae inducing diuresis to remove edema, only dispel the wind
Bitterly, have analgesia, antipyretic, antiinflammatory is of flaccid muscles, diuresis, antianaphylaxis shock and the effect that reduces blood pressure；Cortex erythrinae cold-dispelling, logical
Meridians, parasite killing, have heat clearing and damp drying wind-expelling pain-stopping, fresh poisoning worm to take effect, preferable to acute eczema effect；Caulis Spatholobi activating blood circulation,
Channels sootheing and network vessel quickening, has promoting the circulation of blood to promote blood circulation, warms up the effect of reducing blood pressure of waist knee joint；Flos Carthami is invigorated blood circulation latus rectum, eliminating stasis to stop pain, has blood circulation promoting and blood stasis dispelling, wet dissipation
Go the effect swollen.
Difference according to feedstock property in the preparation method of the present invention, separately processes ground Os Caprae seu Ovis and other raw materials, first will
Raw material in addition to ground Os Caprae seu Ovis is washed after ethanol extracts, then the method for fractional distillation, obtains intermediate products I；Again by ground Os Caprae seu Ovis boiling
After, the method extracting fractional distillation again with ethanol, obtain intermediate products II, finally mixing adds benzoic acid and obtains finished product.
The invention have the benefit that the treatment rheumatism of the present invention, the Chinese medicine composition of gout cure mainly rheumatism, rheumatoid,
Gout, rheumatic heart disease, rheumatic arthritis, sciatica, scapulohumeral periarthritis；Rheumatoid, gout there is specially good effect.
The finished product prepared has effect of blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, alleviating pain and detumescence；To rheumatism, rheumatoid and gout etc.
Disease have effective fast, curative effect high, safety and toleration all preferably feature, and rheumatoid factor can be made to turn to feminine gender from the positive
Reach the purpose cured, uric acid index can be made to significantly reduce, Shorten the Treatment Process, reach the purpose cured.
The treatment rheumatism of the present invention, the preparation method of Chinese medicine composition of gout are according to Traditional Chinese medical theory, in conjunction with existing
For technology of preparing, the Chinese medicine composition that effective component extracting is made.
Detailed description of the invention
Embodiment 1
A kind of Chinese medicine composition treating rheumatism, gout, is made up of following raw material: ground Os Caprae seu Ovis 4kg, Herba Siegesbeckiae 4kg, Radix Stephaniae Tetrandrae
2kg, Flos Carthami 2kg, Cortex erythrinae 2kg, Caulis Spatholobi 2kg.
Preparation method, comprises the following steps:
(1) compound extraction: being mixed in proportion by all raw materials in addition to ground Os Caprae seu Ovis, mix homogeneously obtains compound, to
Adding the ethanol that concentration is 90% in compound to carry out extracting 10 days, the addition of ethanol was not for there to be compound 1.5cm, feed liquid to divide
From, obtain the compound after lixiviating solution and extraction；Compound after extraction adds water, washs 2 times, collect each washing
Liquid, carries out being mixed to get mixing, washing liquid；Lixiviating solution is 1:5 with the volume ratio of mixing, washing liquid, by lixiviating solution and mixing, washing
Liquid mixes, and mix homogeneously obtains mixed liquor, the most at normal temperatures and pressures mixed liquor is carried out fractional distillation, discards ethanol and ethanol
Boiling point, with purgation fraction, collects the fraction (i.e. collecting boiling point is the fraction of 78.2-97 DEG C) that ethanol boiling point is with less than up to 97 DEG C,
Obtaining intermediate products I, the quality of compound is 1 gram: 2.5 milliliters with the volume ratio of intermediate products I；
(2) process of Os Caprae seu Ovis: smashed by ground Os Caprae seu Ovis, adds water and does not crosses ground Os Caprae seu Ovis 4cm, and at 90 DEG C, boiling 3 times, boil every time
The time of system is 1.5 hours, discards ground Os Caprae seu Ovis, collects each water cooking liquid and obtains mixing water cooking liquid, adds in mixing water cooking liquid
Entering the ethanol that concentration is 90%, the addition of ethanol is the 1/3 of water cooking liquid weight, and mix homogeneously obtains material liquid；Material liquid is quiet
Carry out fractional distillation after putting 10 days, discard ethanol and ethanol boiling point with purgation fraction, retain the above fraction of ethanol boiling point, obtain middle product
Product II, the quality of ground Os Caprae seu Ovis and intermediate products II volume ratio are 1 gram: 2.5 milliliters；
(3) mixing: intermediate products I and intermediate products II are mixed, carries out sterilizing 15 after mix homogeneously at 121 DEG C
Minute, get product.
Embodiment 2
A kind of Chinese medicine composition treating rheumatism, gout, is made up of following raw material:
Ground Os Caprae seu Ovis 6kg, Herba Siegesbeckiae 2kg, Radix Stephaniae Tetrandrae 1kg, Flos Carthami 4kg, Cortex erythrinae 1kg, Caulis Spatholobi 4kg, Caulis Trachelospermi 3kg, anti-
Wind 2kg.
Preparation method, comprises the following steps:
(1) compound extraction: being mixed in proportion by all raw materials in addition to ground Os Caprae seu Ovis, mix homogeneously obtains compound, to
Adding the ethanol that concentration is 80% in compound to carry out extracting 15 days, the addition of ethanol was not for there to be compound 1cm, feed liquid to divide
From, obtain the compound after lixiviating solution and extraction；Compound after extraction adds water, washs 2 times, collect each washing
Liquid, carries out being mixed to get mixing, washing liquid；Lixiviating solution is 1:4 with the volume ratio of mixing, washing liquid, by lixiviating solution and mixing, washing
Liquid mixes, and mix homogeneously obtains mixed liquor, then mixed liquor is carried out fractional distillation, discards ethanol and ethanol boiling point evaporates with purgation
Point, collection ethanol boiling point, with the fraction of less than up to 97 DEG C, obtains intermediate products I, the quality of compound and the body of intermediate products I
Long-pending ratio is 1 gram: 2 milliliters；
(2) process of Os Caprae seu Ovis: smashed by ground Os Caprae seu Ovis, adds water and does not crosses ground Os Caprae seu Ovis 2cm, and at 95 DEG C, boiling 3 times, boil every time
The time of system is 1 hour, discards ground Os Caprae seu Ovis, collects each water cooking liquid and obtains mixing water cooking liquid, adds in mixing water cooking liquid
Concentration is the ethanol of 80%, and the addition of ethanol is the 1/2 of water cooking liquid weight, and mix homogeneously obtains material liquid；Material liquid is stood
Carry out fractional distillation after 15 days, discard ethanol and ethanol boiling point with purgation fraction, retain the above fraction of ethanol boiling point, obtain intermediate products
II, the quality of ground Os Caprae seu Ovis and intermediate products II volume ratio are 1 gram: 2 milliliters；
(3) mixing: intermediate products I and intermediate products II are mixed, adds benzyl alcohol after mix homogeneously, benzoic
Addition is the 0.01% of mixing intermediate product weight, carries out sterilizing, thus obtaining the product finished product after mix homogeneously.
Embodiment 3
A kind of Chinese medicine composition treating rheumatism, gout, is made up of following raw material:
Ground Os Caprae seu Ovis 5kg, Herba Siegesbeckiae 3kg, Radix Stephaniae Tetrandrae 1.5kg, Flos Carthami 3kg, Cortex erythrinae 1.5kg, Caulis Spatholobi 3kg, Caulis Trachelospermi
2kg, Radix Saposhnikoviae 1kg, Cortex Eucommiae 3kg, Radix Gentianae Marcrophyllae 2.
Preparation method, comprises the following steps:
(1) compound extraction: being mixed in proportion by all raw materials in addition to ground Os Caprae seu Ovis, mix homogeneously obtains compound, to
Adding the ethanol that concentration is 96% in compound to carry out extracting 7 days, the addition of ethanol was not for there be compound 2cm, and feed liquid separates,
Obtain the compound after lixiviating solution and extraction；Compound after extraction adds water, washs 3 times, collect each cleaning mixture,
Carry out being mixed to get mixing, washing liquid；Lixiviating solution is 1:6 with the volume ratio of mixing, washing liquid, lixiviating solution and mixing, washing liquid is entered
Row mixing, mix homogeneously obtains mixed liquor, then mixed liquor is carried out fractional distillation, discards ethanol and ethanol boiling point with purgation fraction,
Retaining the fraction of more than ethanol boiling point, obtain intermediate products I, the quality of compound is 1 gram: 3 millis with the volume ratio of intermediate products I
Rise；
(2) process of Os Caprae seu Ovis: smashed by ground Os Caprae seu Ovis, adds water and does not crosses ground Os Caprae seu Ovis 5cm, and at 85 DEG C, boiling 3 times, boil every time
The time of system is 2 hours, discards ground Os Caprae seu Ovis, collects each water cooking liquid and obtains mixing water cooking liquid, adds in mixing water cooking liquid
Concentration is the ethanol of 96%, and the addition of ethanol is the 1/3 of water cooking liquid weight, and mix homogeneously obtains material liquid；Material liquid is stood 7
Carry out fractional distillation after it, discard ethanol and ethanol boiling point and with the fraction of less than up to 97 DEG C, obtain with purgation fraction, collection ethanol boiling point
To intermediate products II, the quality of ground Os Caprae seu Ovis and intermediate products II volume ratio are 1 gram: 3 milliliters；
(3) mixing: intermediate products I and intermediate products II are mixed, adding concentration after mix homogeneously is the benzene of 1wt%
Methanol, benzoic addition is the 0.05% of mixing intermediate product weight, carries out sterilizing, thus obtaining the product finished product after mix homogeneously.
Above-described embodiment formula is inventor's result through test of many times research, can play preferably treatment through on probation
Rheumatism, rheumatoid, gout, scapulohumeral periarthritis etc..
As a example by Clinical practice 298 example, rheumatism 85 people in case, rheumatic arthritis 70 people, rheumatoid arthritis
61 people, gout 50 people, sciatica 10 people, scapulohumeral periarthritis 14 people, rheumatic heart disease 3 people, hyperosteogeny 5 people, all application send out
Bright described wind-expelling and pain-alleviating injection is treated.The diseases such as rheumatoid, rheumatic arthritis, gout can be treated well.
By the injection obtained by the present invention, once a day, each four milliliters, intramuscular injection is used.Treating two courses for the treatment of, a course for the treatment of is
15 days.Wherein effectively case is 298 examples, and obvious effective rate is 100%；Cure rate is 98.9%.
Model case；
1, high certain, 48 years old, man, 20 years causes drenched with rain greatly rear right shoulder and double anklebone pain, and the cloudy day rains and increases the weight of, and has waist
Portion's trauma history.Use SHANGSHI ZHITONG GAO, musk rheumatic plaster to treat, but effect is the most notable.Right shoulder joint over ill 20 years
Joint, double lower ankle joint pain, rainy day acid is swollen, and ankle joint is walked pain, makes a definite diagnosis rheumatic arthritis according to examination in hospital.Through this
One 15 days course for the treatment of of bright embodiment 2 Drug therapy, once a day, intramuscular injection, each 4ml, have no adverse reaction during treatment, double
Lower ankle pain relief, but the cloudy day still have and slightly show sense, examine through hospital and confirm as taking a turn for the better.
2, Huang, 19 years old, man, the left foot of this patient had joint painful swelling disease history, controls through penicillin and relevant medicine thereof
Treat, recur after taking effect at that time 6 hours, time and during pain the most bitterly, through rheumatism out-patient department of institute of traditional Chinese medicine check be diagnosed as acute
Rheumatism.Through the embodiment of the present invention 1 Drug therapy inject once a day, intramuscular injection, each 4ml, after four days, ankle joint disappears
Swollen, inject ten days rear feet and all subside a swelling, but joint also has pain slightly, can go to work in the fields, through controlling after injecting 15 days
After treating one month overcast and rainy, the painless feel in joint, strong wind sky, through examination in hospital confirm as cure.
3, Chen, 50 years old, man, this patient walked difficult, is diagnosed as gout to examination in hospital.This patient, once suffered from before 6 years
Gout, through the embodiment of the present invention 3 medicine intramuscular injection, once a day, each 4ml, 15 days course for the treatment of, recovery from illness can normally be walked
Road.After 5 years, this patient eats seafood to have the beer and causes secondary gout, it is impossible to walk, through the embodiment of the present invention 3 injection for treating two
Patient's recovery from illness after the individual course for the treatment of, so far without recurrence.
4, in certain, 65 years old, male, during this morbidity, heel, toe swelling pain are unbearably, it is impossible to walking, examine through hospital
Control and be diagnosed as gout, undergo various treatments invalid, from November, 2015 through the embodiment of the present invention 2 Drug therapy, experience two treatments
The treatment of journey, once a day, intramuscular injection, each 4ml, arthralgia disappears, and self-care life of can normally walking, by hospital
Inspection is defined as recovery from illness.
5, Tang, 53 years old, female, this patient's joints of hand and gonalgia, it is diagnosed as rheumatism through hospital.Implement through the present invention
Example 3 product is treated, and experiences two courses for the treatment of, and once a day, intramuscular injection, after each 4ml, hand pain eliminates, and can normally do washing
Cook, be defined as recovery from illness through examination in hospital.
The present invention is not limited to above-mentioned preferred forms, and anyone can show that under the enlightenment of the present invention other are various
The product of form, no matter but in its shape or structure, make any change, every have same as the present application or akin skill
Art scheme, within all falling within protection scope of the present invention.
Claims (10)
1. the Chinese medicine composition treating rheumatism, gout, it is characterised in that: include the raw material of following weight portion: ground Os Caprae seu Ovis 4-6
Part, Herba Siegesbeckiae 2-4 part, Radix Stephaniae Tetrandrae 1-2 part, Flos Carthami 2-4 part, Cortex erythrinae 1-2 part, Caulis Spatholobi 2-4 part.
Treatment rheumatism the most according to claim 1, the Chinese medicine composition of gout, it is characterised in that: include following weight portion
Raw material: ground Os Caprae seu Ovis 4-6 part, Herba Siegesbeckiae 2-4 part, Radix Stephaniae Tetrandrae 1-2 part, Flos Carthami 2-4 part, Cortex erythrinae 1-2 part, Caulis Spatholobi 2-4 part, fall
Stone rattan 2-3 part, Radix Saposhnikoviae 1-2 part.
Treatment rheumatism the most according to claim 1, the Chinese medicine composition of gout, it is characterised in that: include following weight portion
Raw material: ground Os Caprae seu Ovis 4-6 part, Herba Siegesbeckiae 2-4 part, Radix Stephaniae Tetrandrae 1-2 part, Flos Carthami 2-4 part, Cortex erythrinae 1-2 part, Caulis Spatholobi 2-4 part, fall
Stone rattan 2-3 part, Radix Saposhnikoviae 1-2 part, Cortex Eucommiae 2-4 part, Radix Gentianae Marcrophyllae 1-2 part.
4. a preparation method for the Chinese medicine composition for the treatment of rheumatism as described in claims 1 to 3 is arbitrary, gout, its feature
It is: comprise the following steps:
(1) compound extraction: being mixed in proportion by all raw materials in addition to ground Os Caprae seu Ovis, mix homogeneously obtains compound, to described
Adding concentration in compound is that the ethanol of 80-96% carries out extraction 7-15 days, and feed liquid separates, and obtain after lixiviating solution and extraction is mixed
Close material；Compound after described extraction adds water, washs 2-3 time, collect each cleaning mixture, carry out being mixed to get mixing
Cleaning mixture；Described lixiviating solution and described mixing, washing liquid being mixed, mix homogeneously obtains mixed liquor, then to described mixing
Liquid carries out fractional distillation, discards ethanol and ethanol boiling point and with the fraction of less than up to 97 DEG C, obtains with purgation fraction, collection ethanol boiling point
Intermediate products I；
(2) process of Os Caprae seu Ovis: ground Os Caprae seu Ovis is smashed, add water boiling several times, discard ground Os Caprae seu Ovis, collect each water cooking liquid and obtain
To mixing water cooking liquid, adding concentration in described mixing water cooking liquid is the ethanol of 80-96%, and mix homogeneously obtains material liquid；By institute
State material liquid to stand after 7-15 days and carry out fractional distillation, discard ethanol and ethanol boiling point with purgation fraction, collect ethanol boiling point with up to
The fraction of less than 97 DEG C, obtains intermediate products II；
(3) mixing: described intermediate products I and described intermediate products II are mixed, carries out sterilizing, thus obtaining the product one-tenth after mix homogeneously
Product.
Treatment rheumatism the most according to claim 4, the preparation method of Chinese medicine composition of gout, it is characterised in that: step
(1) lixiviating solution described in is 1:4-6 with the volume ratio of described mixing, washing liquid.
Treatment rheumatism the most according to claim 4, the preparation method of Chinese medicine composition of gout, it is characterised in that: step
(1) addition of ethanol described in was not for have described compound 1-2cm.
Treatment rheumatism the most according to claim 4, the preparation method of Chinese medicine composition of gout, it is characterised in that: step
(1) quality of described compound is 1 gram: 2-3 milliliter with the volume ratio of described intermediate products I.
Treatment rheumatism the most according to claim 4, the preparation method of Chinese medicine composition of gout, it is characterised in that: step
(2) described in quality and described intermediate products II volume ratio of Os Caprae seu Ovis be 1 gram: 2-3 milliliter.
Treatment rheumatism the most according to claim 4, the preparation method of Chinese medicine composition of gout, it is characterised in that: step
(2) addition of ethanol described in is the 1/3-1/2 of described water cooking liquid weight；Described in step (2), the temperature of boiling is 85-95
DEG C, the number of times of described boiling is 3 times, and the time of each described boiling is 1-2 hour.
Treatment rheumatism the most according to claim 4, the preparation method of Chinese medicine composition of gout, it is characterised in that: step
(3) adding benzyl alcohol in backward described finished product, described benzoic addition is the 0.01-0.5% of described finished weight.
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Application publication date: 20170104 |